Resumo: A epidemia de HIV/aids está longe de terminar. Ainda é muito real, especialmente em populações-chave, como homens que fazem sexo com homens (HSH), travestis e pessoas transgênero. Projetos de ampliação da testagem rápida anti-HIV são iniciativas estratégicas que visam à identificação mais precoce possível do status sorológico dos indivíduos e, consequentemente, ao tratamento precoce, à triagem de parceiros sexuais e à ampliação das ações preventivas para interrupção da cadeia de transmissão. Assim, este estudo se propõe a mapear, descrever e sistematizar os projetos de expansão da testagem rápida para HIV realizados de 2004 a 2021 no Brasil, destacando a contribuição em curso das organizações da sociedade civil e discutindo a interoperabilidade e a cooperação resultantes dos processos de governança pública. Foram selecionados 67 documentos para análise, incluindo 30 publicações científicas recuperadas de bases de dados eletrônicas e 37 documentos produzidos por instituições governamentais e organizações não governamentais (ONGs). Os projetos mapeados foram: Fique Sabendo, Quero Fazer, A Hora É Agora, Viva Melhor Sabendo e Viva Melhor Sabendo Jovem. Os resultados mostram que os projetos utilizaram estratégias adaptadas à população-chave, como unidades móveis de testagem, educação entre pares e abordagens inovadoras de engajamento comunitário. Tais ações foram possíveis graças à cooperação e interoperabilidade efetivas entre as partes interessadas participantes, especialmente as ONGs.

Abstract: The HIV/AIDS epidemic remains a persistent and real issue, especially in key populations such as men who have sex with men (MSM), travestis and transgender persons. Projects for expanding rapid HIV testing are strategic initiatives aimed at the earliest possible identification of individuals’ serological status and thus early treatment, screening of sex partners, and upscaling of preventive actions to interrupt the transmission chain. This study thus maps, describes, and systematizes the projects for expanding rapid HIV testing implemented from 2004 to 2021 in Brazil, highlighting the on-going contribution of civil society organizations and discussing the interoperability and cooperation resulting from public governance processes. We selected 67 documents for analysis, including 30 scientific publications retrieved from electronic databases and 37 documents produced by government institutions and nongovernmental organizations (NGOs). Find Out (Fique Sabendo), I Want to Get Tested (Quero Fazer), The Time is Now (A Hora É Agora), Live Better Knowing (Viva Melhor Sabendo), and Live Better Knowing Young (Viva Melhor Sabendo Jovem) were the projects mapped. Results show that the projects have used strategies adapted to the key population, such as mobile testing units, peer education, and innovative community engagement approaches. Such actions were enabled by effective cooperation and interoperability between participating stakeholders, especially NGOs.

Resumen: La epidemia de VIH/SIDS está lejos de terminar. Sigue siendo muy real, sobre todo en poblaciones clave, como hombres que tienen sexo con hombres (HSH), travestís y personas transgénero. Proyectos para ampliar las pruebas rápidas anti-VIH son iniciativas estratégicas que tienen el objetivo de identificar el estado serológico de las personas lo antes posible y, consiguientemente, hacer el tratamiento precoz, el triaje de las parejas sexuales y ampliar las acciones preventivas para interrumpir la cadena de transmisión. Así, este estudio tiene el objetivo de mapear, describir y sistematizar los proyectos de expansión de las pruebas rápidas del VIH realizados entre 2004 y 2021 en Brasil, resaltando la contribución en curso de los organismos de la sociedad civil y discutiendo la interoperabilidad y la cooperación que resultan de los procesos de gobernanza pública. Se seleccionaron 67 documentos para el análisis, entre ellos 30 publicaciones científicas recuperadas de bases de datos electrónicas y 37 documentos producidos por instituciones gubernamentales y organizaciones no gubernamentales (ONGs). Los proyectos mapeados fueron: Para que Sepas (Fique Sabendo), Quiero Hacer (Quero Fazer), La Hora Es Ahora (A Hora É Agora), Viva Mejor Sabiendo (Viva Melhor Sabendo) y Viva Mejor Sabiendo Joven (Viva Melhor Sabendo Jovem). Los resultados demuestran que los proyectos utilizaron estrategias adaptadas a la población clave, como las unidades móviles de prueba, educación entre pares y enfoques innovadores de participación comunitaria. Estas acciones fueron posibles gracias a la cooperación e interoperabilidad efectivas entre las partes interesadas participantes, sobre todo las ONGs.

RESUMEN Objetivo: mapear los trastornos mentales recurrentes comunes en pacientes sometidos a trasplante de células madre hematopoyéticas. Métodos: se trata de una revisión de alcance realizada en enero de 2022 en bases de datos electrónicas y repositorios de disertaciones y tesis. Se incluyeron publicaciones que respondieron a la pregunta de investigación, cumplieron con el objetivo del estudio y estaban disponibles en su totalidad en formato electrónico, en cualquier idioma. Resultados: la muestra estuvo compuesta por 28 estudios, 14 de los cuales fueron publicados en los Estados Unidos de América. Los trastornos mentales comunes encontrados fueron depresión, ansiedad, estrés postraumático y trastornos del estado de ánimo. Se mencionaron 20 síntomas, entre los más prevalentes se encuentran fatiga y trastornos del sueño/insomnio. Conclusiones: se destacó la dificultad e importancia de realizar el diagnóstico diferencial de estos trastornos, ya que sus síntomas pueden confundirse con otros problemas de salud y tienen un fuerte potencial de interferir en la evolución del paciente. Objetivo hematopoyéticas Métodos 202 tesis investigación electrónico idioma Resultados 2 estudios 1 América depresión ansiedad ánimo sueñoinsomnio sueño insomnio sueño/insomnio Conclusiones paciente

ABSTRACT Objective: to map common recurrent mental disorders in patients undergoing hematopoietic stem cell transplantation. Methods: this is a scoping review carried out in January 2022 in electronic databases and repositories of dissertations and thesis. Studies that answered the research question, met the objective of the study and were available in full electronically, in any language, were included. Results: the sample consisted of 28 studies, 14 of which were published in the United States of America. The common mental disorders found were depressive, anxiety, post-traumatic stress and mood disorders. Twenty symptoms were mentioned, among the most prevalent are fatigue and sleep disorders/insomnia. Conclusions: the difficulty and importance of carrying out the differential diagnosis of these disorders were highlighted, since their symptoms can be confused with other health problems and have a strong potential to interfere with patients’ evolution. Objective transplantation Methods 202 thesis question electronically language included Results 2 studies 1 America depressive anxiety posttraumatic post traumatic mentioned disordersinsomnia insomnia disorders/insomnia Conclusions highlighted evolution 20

RESUMO Objetivo: mapear os transtornos mentais comuns recorrentes em pacientes submetidos ao transplante de células-tronco hematopoéticas. Métodos: trata-se de revisão de escopo realizada em janeiro de 2022 em bases de dados eletrônicas e repositórios de dissertações e tese. Foram incluídas publicações que respondessem à questão de pesquisa, atendessem ao objetivo do estudo e que estivessem disponíveis na íntegra em meio eletrônico, em qualquer idioma. Resultados: a amostra foi composta por 28 estudos, dos quais 14 foram publicados nos Estados Unidos da América. Os transtornos mentais comuns encontrados foram os transtornos depressivos, de ansiedade, estresse pós-traumático e de humor. Foram citados 20 sintomas, entre os mais prevalentes estão a fadiga e distúrbios do sono/insônia. Conclusões: evidenciaram-se a dificuldade e a importância de realizar o diagnóstico diferencial desses transtornos, uma vez que seus sintomas podem ser confundidos com outros problemas de saúde e têm forte potencial para interferir na evolução do paciente. Objetivo célulastronco células tronco hematopoéticas Métodos tratase trata se 202 tese pesquisa eletrônico idioma Resultados 2 estudos 1 América depressivos ansiedade póstraumático pós traumático humor sonoinsônia sono insônia sono/insônia Conclusões evidenciaramse evidenciaram paciente

Abstract This study compares the effects of virus-cell interactions among SARS-CoV-2 variants of concern (VOCs) isolated in Brazil in 2021, hypothesizing a correlation between cellular alterations and mortality and between viral load and transmissibility. For this purpose, reference isolates of Alpha, Gamma, Zeta, and Delta variants were inoculated into monolayers of Vero-E6 cells. Viral RNA was quantified in cell supernatants by RT‒PCR, and infected cells were analyzed by Transmission Electron Microscopy (TEM) for qualitative and quantitative evaluation of cellular changes 24, 48, and 72 hours postinfection (hpi). Ultrastructural analyses showed that all variants of SARS-CoV-2 altered the structure and function of mitochondria, nucleus, and rough endoplasmic reticulum of cells. Monolayers infected with the Delta variant showed the highest number of modified cells and the greatest statistically significant differences compared to those of other variants. Viral particles were observed in the cytosol and the cell membrane in 100 % of the cells at 48 hpi. Alpha showed the highest mean particle diameter (79 nm), and Gamma and Delta were the smallest (75 nm). Alpha and Gamma had the highest particle frequency per field at 48 hpi, while the same was observed for Zeta and Delta at 72 hpi and 24 hpi, respectively. The cycle threshold of viral RNA varied among the target protein, VOC, and time of infection. The findings presented here demonstrate that all four VOCs evaluated caused ultrastructural changes in Vero-E6 cells, which were more prominent when infection occured with the Delta variant. viruscell virus SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- (VOCs 2021 transmissibility purpose VeroE6 VeroE Vero E6 E Vero-E RTPCR RT PCR RT‒PCR TEM (TEM 7 . (hpi) mitochondria nucleus 10 4 79 (7 nm, nm , nm) 75 nm. respectively protein VOC SARS-CoV 202 (hpi 1 ( 20

Abstract Objective The present in vitro study incorporated niobium oxyhydroxide fillers into an experimental high-viscosity bulk-fill resin composite to improve its mechanical performance and provide it a bioactive potential. Methodology Scanning electron microscopy synthesized and characterized 0.5% niobium oxyhydroxide fillers, demonstrating a homogeneous morphology that represented a reinforcement for the feature. Fillers were weighed, gradually added to the experimental resin composite, and homogenized for one minute, forming three groups: BF (experimental high-viscosity bulk-fill resin composite; control), BF0.5 (experimental high-viscosity bulk-fill resin composite modified with 0.5% niobium oxyhydroxide fillers), and BFC (commercial bulk-fill resin composite Beautifil Bulk U, Shofu; positive control). In total, 10 specimens/groups (8 × 2 × 2 mm) underwent flexural strength (FS) tests in a universal testing machine (Instron) (500N). Resin composites were also assessed for Knoop hardness (KH), depth of cure (DoC), degree of conversion (DC), elastic modulus (E), and degree of color change (ΔE). The bioactive potential of the developed resin composite was evaluated after immersing the specimens into a simulated body fluid in vitro solution and assessing them using a Fourier-transformed infrared spectroscope with an attenuated total reflectance accessory. One-way ANOVA, followed by the Tukey’s test (p<0.05), determined FS, DC, KH, and ΔE. For DoC, ANOVA was performed, which demonstrated no significant difference between groups (p<0.05). Conclusions The high-viscosity bulk-fill resin composite with 0.5% niobium oxyhydroxide fillers showed promising outcomes as reinforcement agents and performed well for bioactive potential, although less predictable than the commercial resin composite with Giomer technology. highviscosity high viscosity bulkfill bulk fill 05 0 5 0.5 feature weighed minute control, control , control) BF05 BF0 BF0. fillers) U Shofu control. . 1 specimensgroups 8 ( mm FS (FS Instron (Instron 500N. 500N N (500N) KH (KH) DoC (DoC) DC (DC) E, E (E) ΔE (ΔE) Fouriertransformed Fourier transformed accessory Oneway One way Tukeys Tukey s p<0.05, p005 p p<0.05 (p<0.05) p<0.05. technology 0. (500N (KH (DoC (DC (E (ΔE p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

Résumé Cet article mobilise la littérature sur l’isomorphisme institutionel et les mouvements sociaux pour expliquer la diffusion au Brésil des procédures de validation des autodéclarations des candidats à l’admission dans les universités fédérales par le biais de quotas raciaux. La diffusion de ces procédures a transformé la manière dont le droit aux actions affirmatives est compris et a produit des changements organisationnels. En analysant des documents et des entretiens, l’article identifie les mécanismes coercitifs, mimétiques et normatifs en jeu et examine leur genèse. Il montre que ceux-ci ont découlé des interactions entre les étudiants universitaires, le personnel technique-administratif et les enseignants des universités, ainsi que des organisations du mouvement noir et des agences de l’État, engagés dans l’objectif de protéger les actions affirmatives. Les implications pour l’étude du changement dans l’enseignement supérieur et des relations raciales au Brésil sont discutées. lisomorphisme l isomorphisme ladmission admission raciaux organisationnels entretiens larticle coercitifs genèse ceuxci ceux ci universitaires techniqueadministratif technique administratif lÉtat, lÉtat État, État l’État lobjectif objectif létude étude lenseignement enseignement discutées

Resumen Este artículo utiliza la literatura sobre isomorfismo institucional y movimientos sociales para explicar la difusión de procedimientos de validación de las autodeclaraciones de los candidatos a admisión en universidades federales en Brasil por medio de cuotas raciales. La difusión de esos procedimientos transformó el modo en que el derecho a las acciones afirmativas es comprendido y produjo cambios organizacionales. Por medio del análisis de documentos y entrevistas, el artículo identifica los mecanismos coercitivos, miméticos y normativos en juego y examina su génesis. Se muestra que estos mecanismos se derivaban de las interacciones entre estudiantes universitarios, funcionarios técnico-administrativos y docentes de las universidades, así como organizaciones del movimiento negro y de agencias del estado, comprometidos con el objetivo de proteger las acciones afirmativas. Se discuten las implicaciones para estudiar el cambio en la enseñanza superior y las relaciones raciales en Brasil. organizacionales entrevistas coercitivos génesis universitarios técnicoadministrativos técnico administrativos estado

Abstract This article draws insights from the literature on institutional isomorphism and social movements theory to explain the diffusion in Brazil of procedures for validating the self-identification of candidates for admission to federal universities through racial quotas. The diffusion of these procedures has transformed how the right to affirmative action is understood and how it has led to organizational challenges. By analyzing documents and interviews, this article identifies the coercive, mimetic, and normative mechanisms at play. It shows that they derived from interactions among Black university students, staff, faculty members, and organizations of the black movement and state agencies, all engaged in protecting racial affirmative action. Implications for studying change in Brazil’s higher education and race relations are also discussed. Higher education and race relations in Brazil are also discussed. selfidentification self identification quotas challenges interviews coercive mimetic play students staff members agencies Brazils s discussed

Resumo Esse artigo mobiliza a literatura sobre isomorfismo institucional e movimentos sociais para explicar a difusão no Brasil de procedimentos de validação das autodeclarações dos candidatos à admissão em universidades federais por meio de cotas raciais. A difusão desses procedimentos transformou o modo como o direito às ações afirmativas é compreendido e produziu mudanças organizacionais. Por meio da análise de documentos e entrevistas, o artigo identifica os mecanismos coercivos, miméticos e normativos em jogo e examina sua gênese. Ele mostra que esses derivaram das interações entre estudantes universitários, funcionários técnico-administrativos e docentes das universidades, assim como organizações do movimento negro e de agências do estado, engajados no objetivo de proteger as ações afirmativas. Implicações para estudar mudança no ensino superior e nas relações raciais no Brasil são discutidas. organizacionais entrevistas coercivos gênese universitários técnicoadministrativos técnico administrativos estado discutidas

ABSTRACT This experiment was carried out to evaluate the effects of organic acids on the intestinal integrity and productive performance of broiler chickens experimentally inoculated with Salmonella Enteritidis. Additionally, Salmonella colonization levels in internal organs were evaluated. The study included 576 one-day-old CobbTM male broilers, distributed into eight treatment groups and six replicates. A completely randomized experimental design (encapsulated butyric acid × inoculation by Salmonella Enteritidis) was used. Poultry was orally inoculated with Salmonella Enteritidis in the first day (0 or 2.0 × 106 CFU/mL) and after 22 days of age (0 or 1.0 × 109 CFU/ mL). The butyric acid was added to the feed in different concentration (treatments 0.03, 0.075, and 0.15%), and the chickens were raised up to 42 days old. Encapsulated butyric acid at 0.03% increased the body weight gain and the average weight of the chickens up to 21 days old. After 14 days old, the butyric acid had a positive effect on jejunum villus. Encapsulated butyric acid at 0.03% in feed improves the performance and intestinal integrity of chickens. Additionally evaluated 57 onedayold one old broilers replicates encapsulated used 0 ( 20 2 2. 10 CFU/mL CFUmL CFU mL 1 1. mL. . mL) treatments 003 03 0.03 0075 075 0.075 0.15%, 015 0.15% , 15 0.15%) 4 villus 5 00 0.0 007 07 0.07 01 0.15 0. 0.1

Abstract Objective The video otoscope has already proven to be useful for the diagnosis of several pathologies, so the objective of this study was to evaluate the diagnostic accuracy of the video otoscope in cases of tympanic membrane perforation. Methods This is a diagnostic accuracy study performed at the hearing health division of a tertiary-level referral hospital. Patients older than 8 years of age who had any symptom that could be related to perforation (otalgia, otorrhea, tinnitus, and/or hypoacusis) were invited to participate in the study. Participants were evaluated by three different diagnostic methods (otomicroscope, conventional otoscope, and video otoscope) performed by three different evaluators in a blind fashion. The microscope was considered the reference standard. Results 176 patients were evaluated, totaling 352 tympanic membranes. Twenty-seven tympanic membrane perforations were diagnosed by the microscope, a prevalence of 7.7%. The video otoscope showed a sensitivity of 85.2% (95% CI 81.5%‒88.9%), specificity of 98.1% (95% CI 96.7%‒99.5%) and accuracy of 97.1% (95% CI 95.4 %-98.8 %). The conventional otoscope showed a sensitivity of 96.3% (95% CI 94.3-98.3), specificity of 98.8% (95% CI 97.7-99.9) and accuracy of 98.6% (95% CI 97.4-99.8). The Kappa value between the microscope and the video otoscope was 0.8 and between the microscope and the conventional otoscope was 0.9. Regarding the participants' perception, 53.4% (p < 0.001) considered the video otoscope as the best method for understanding the tympanic membrane condition presented by them. Conclusions The video otoscope showed relevant sensitivity and specificity for clinical practice in the diagnosis of tympanic membrane perforation. Moreover, this is an equipment that can facilitate the patient's understanding of the otologic pathology presented by him/her. In this regard, this method may be important for better patient compliance, requiring further studies to evaluate this hypothesis. Level of evidence Is this diagnostic or monitoring test accurate? (Diagnosis)—Level 2 (Individual cross-sectional studies with consistently applied reference standard and blinding). pathologies tertiarylevel tertiary level hospital otalgia, otalgia (otalgia otorrhea tinnitus andor hypoacusis otomicroscope, otomicroscope (otomicroscope fashion 17 35 membranes Twentyseven Twenty seven 77 7 7.7% 852 85 85.2 95% 95 (95 81.5%‒88.9%, 815889 81.5%‒88.9% , 81 5 88 9 81.5%‒88.9%) 981 98 1 98.1 96.7%‒99.5% 967995 96 99 971 97 97.1 954 4 95. %98.8 988 % 98.8 %-98. %. . %) 963 3 96.3 94.398.3, 943983 94.3 98.3 94 94.3-98.3) 97.799.9 977999 97.7 99.9 97.7-99.9 986 6 98.6 97.499.8. 974998 97.4 99.8 97.4-99.8) 08 0 0. 09 0.9 participants perception 534 53 53.4 p 0.001 0001 001 them Moreover s himher him her him/her regard compliance hypothesis accurate DiagnosisLevel Diagnosis Individual crosssectional cross sectional blinding. blinding blinding) 7.7 85. (9 81588 81.5%‒88.9 98. 96.7%‒99.5 96799 97. %98. %-98 96. 398 94.398.3 94398 943 94. 983 94.3-98.3 799 97.799. 97799 977 999 99. 97.7-99. 499 97.499.8 97499 974 998 97.4-99.8 53. 0.00 000 00 7. ( 8158 81.5%‒88. 96.7%‒99. 9679 %98 %-9 39 94.398. 9439 94.3-98. 79 97.799 9779 97.7-99 49 97.499. 9749 97.4-99. 0.0 815 81.5%‒88 96.7%‒99 967 %9 %- 94.398 94.3-98 97.79 97.7-9 97.499 97.4-99 81.5%‒8 96.7%‒9 94.39 94.3-9 97.7- 97.49 97.4-9 81.5%‒ 96.7%‒ 94.3- 97.4- 81.5% 96.7% 81.5 96.7 81.

Resumen: La epidemia de VIH/SIDS está lejos de terminar. Sigue siendo muy real, sobre todo en poblaciones clave, como hombres que tienen sexo con hombres (HSH), travestís y personas transgénero. Proyectos para ampliar las pruebas rápidas anti-VIH son iniciativas estratégicas que tienen el objetivo de identificar el estado serológico de las personas lo antes posible y, consiguientemente, hacer el tratamiento precoz, el triaje de las parejas sexuales y ampliar las acciones preventivas para interrumpir la cadena de transmisión. Así, este estudio tiene el objetivo de mapear, describir y sistematizar los proyectos de expansión de las pruebas rápidas del VIH realizados entre 2004 y 2021 en Brasil, resaltando la contribución en curso de los organismos de la sociedad civil y discutiendo la interoperabilidad y la cooperación que resultan de los procesos de gobernanza pública. Se seleccionaron 67 documentos para el análisis, entre ellos 30 publicaciones científicas recuperadas de bases de datos electrónicas y 37 documentos producidos por instituciones gubernamentales y organizaciones no gubernamentales (ONGs). Los proyectos mapeados fueron: Para que Sepas (Fique Sabendo), Quiero Hacer (Quero Fazer), La Hora Es Ahora (A Hora É Agora), Viva Mejor Sabiendo (Viva Melhor Sabendo) y Viva Mejor Sabiendo Joven (Viva Melhor Sabendo Jovem). Los resultados demuestran que los proyectos utilizaron estrategias adaptadas a la población clave, como las unidades móviles de prueba, educación entre pares y enfoques innovadores de participación comunitaria. Estas acciones fueron posibles gracias a la cooperación e interoperabilidad efectivas entre las partes interesadas participantes, sobre todo las ONGs. Resumen VIHSIDS SIDS terminar real clave HSH, HSH , (HSH) transgénero antiVIH anti consiguientemente precoz transmisión Así mapear 200 202 Brasil pública 6 análisis 3 ONGs . (ONGs) Fique Sabendo, Quero Fazer, Fazer Fazer) A Agora, Agora Agora) Jovem. Jovem Jovem) prueba comunitaria participantes (HSH 20 (ONGs 2

Abstract: The HIV/AIDS epidemic remains a persistent and real issue, especially in key populations such as men who have sex with men (MSM), travestis and transgender persons. Projects for expanding rapid HIV testing are strategic initiatives aimed at the earliest possible identification of individuals’ serological status and thus early treatment, screening of sex partners, and upscaling of preventive actions to interrupt the transmission chain. This study thus maps, describes, and systematizes the projects for expanding rapid HIV testing implemented from 2004 to 2021 in Brazil, highlighting the on-going contribution of civil society organizations and discussing the interoperability and cooperation resulting from public governance processes. We selected 67 documents for analysis, including 30 scientific publications retrieved from electronic databases and 37 documents produced by government institutions and nongovernmental organizations (NGOs). Find Out (Fique Sabendo), I Want to Get Tested (Quero Fazer), The Time is Now (A Hora É Agora), Live Better Knowing (Viva Melhor Sabendo), and Live Better Knowing Young (Viva Melhor Sabendo Jovem) were the projects mapped. Results show that the projects have used strategies adapted to the key population, such as mobile testing units, peer education, and innovative community engagement approaches. Such actions were enabled by effective cooperation and interoperability between participating stakeholders, especially NGOs. Abstract HIVAIDS AIDS issue MSM, MSM , (MSM) persons individuals treatment partners chain maps describes 200 202 Brazil ongoing on going processes 6 analysis 3 NGOs . (NGOs) Fique Sabendo, Sabendo) Quero Fazer, Fazer Fazer) A Agora, Agora Agora) Viva Jovem mapped population units education approaches stakeholders (MSM 20 (NGOs 2

Resumo: A epidemia de HIV/aids está longe de terminar. Ainda é muito real, especialmente em populações-chave, como homens que fazem sexo com homens (HSH), travestis e pessoas transgênero. Projetos de ampliação da testagem rápida anti-HIV são iniciativas estratégicas que visam à identificação mais precoce possível do status sorológico dos indivíduos e, consequentemente, ao tratamento precoce, à triagem de parceiros sexuais e à ampliação das ações preventivas para interrupção da cadeia de transmissão. Assim, este estudo se propõe a mapear, descrever e sistematizar os projetos de expansão da testagem rápida para HIV realizados de 2004 a 2021 no Brasil, destacando a contribuição em curso das organizações da sociedade civil e discutindo a interoperabilidade e a cooperação resultantes dos processos de governança pública. Foram selecionados 67 documentos para análise, incluindo 30 publicações científicas recuperadas de bases de dados eletrônicas e 37 documentos produzidos por instituições governamentais e organizações não governamentais (ONGs). Os projetos mapeados foram: Fique Sabendo, Quero Fazer, A Hora É Agora, Viva Melhor Sabendo e Viva Melhor Sabendo Jovem. Os resultados mostram que os projetos utilizaram estratégias adaptadas à população-chave, como unidades móveis de testagem, educação entre pares e abordagens inovadoras de engajamento comunitário. Tais ações foram possíveis graças à cooperação e interoperabilidade efetivas entre as partes interessadas participantes, especialmente as ONGs. Resumo HIVaids aids terminar real populaçõeschave, populaçõeschave populações chave, chave populações-chave HSH, HSH , (HSH) transgênero antiHIV anti consequentemente transmissão Assim mapear 200 202 Brasil pública 6 análise 3 ONGs . (ONGs) Fazer Agora Jovem populaçãochave, populaçãochave população população-chave comunitário participantes (HSH 20 (ONGs 2

BACKGROUND Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for Leishmania biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level of virulence. OBJECTIVES We reported several aspects of L. tarentolae biology including glycoconjugates, proteolytic activities and metabolome composition in comparison to pathogenic species (Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum and Leishmania major). METHODS Parasites were cultured for extraction and purification of lipophosphoglycan (LPG), immunofluorescence probing with anti-gp63 and resistance against complement. Parasite extracts were also tested for proteases activity and metabolome composition. FINDINGS Leishmania tarentolae does not express LPG on its surface. It expresses gp63 at lower levels compared to pathogenic species and, is highly sensitive to complement-mediated lysis. This species also lacks intracellular/extracellular activities of proteolytic enzymes. It has metabolic differences with pathogenic species, exhibiting a lower abundance of metabolites including ABC transporters, biosynthesis of unsaturated fatty acids and steroids, TCA cycle, glycine/serine/threonine metabolism, glyoxylate/dicarboxylate metabolism and pentose-phosphate pathways. MAIN CONCLUSIONS The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions. nonpathogenic non However L glycoconjugates amazonensis braziliensis major. major . major) LPG, , (LPG) antigp63 antigp anti gp anti-gp6 complement surface gp6 complementmediated mediated lysis intracellularextracellular intracellular extracellular enzymes transporters steroids cycle glycineserinethreonine glycine serine threonine glyoxylatedicarboxylate glyoxylate dicarboxylate pentosephosphate pentose phosphate pathways features hostparasite host parasite interactions (LPG antigp6 anti-gp

This academic article investigates the performance of dye-sensitized solar cells (DSSCs), which are affected by various defects like charge recombination, high impedance, and low power conversion efficiency due to complex physicochemical phenomena. The study explores different materials and processes to enhance DSSC performance, with a focus on photoanode development. Tin dioxide, tin chloride II dihydrate, copper oxide, boric acid, and sodium phosphate are utilized to fabricate the photoanodes. A thermal treatment at 450°C for 30 minutes precedes dye assembly on the photoanode surface. Results show that the tin chloride II dihydrate-modified photoanode outperforms others, achieving higher open-circuit voltage (0.50V), current density (9.58 mAcm-2), fill factor (0.37), and power conversion efficiency (1.77%). The study suggests that tin salt particles positively impact voltage, current, electron transport, and charge separation, enhancing overall cell performance. Charge recombination significantly affects power conversion efficiency and impedance, but accurately quantifying it remains challenging. Lower recombination levels favor efficiency, while higher levels reduce it. dyesensitized sensitized DSSCs, DSSCs , (DSSCs) impedance phenomena development dioxide dihydrate oxide acid photoanodes 450C C 450 3 surface dihydratemodified modified others opencircuit open circuit 0.50V, 050V V 0.50V 0 50V (0.50V) 9.58 958 9 58 (9.5 mAcm2, mAcm2 mAcm 2 mAcm-2) 0.37, 037 0.37 37 (0.37) 1.77%. 177 1.77% . 1 77 (1.77%) transport separation challenging (DSSCs 45 (0.50V 9.5 95 5 (9. mAcm-2 03 0.3 (0.37 17 1.77 7 (1.77% 4 9. (9 mAcm- 0. (0.3 1.7 (1.77 ( (0. 1. (1.7 (0 (1. (1

Abstract Background Pathologies involving the heart are still the main causes of death, and acute myocardial infarction (AMI) is consistently present in this index. The two-minute walk test (2MWT) is ideal for assessing the functional capacity of this patient. Objective To describe the feasibility of the 2MWT in older people after AMI. Methods This is a cross-sectional study. At hospital discharge, patients were invited to perform the 2MWT. Before starting the test, systolic blood pressure (SBP), diastolic blood pressure (DBP), peripheral oxygen saturation (SpO2), heart rate (HR) and the Double Product (DP) were checked. After checking the vital signs, the patients were accompanied by an examiner, who was positioned laterally to ensure safety and verbally encouraged during the test; after the completion of the test, all vital signs were reassessed in two moments, at the immediate end and after 20 minutes of rest. ANOVA was used for the comparison of pre and post-test and pre and recovery. A p<0.05 was considered significant. Results We evaluated 51 patients, 4 (80%) males with a mean age of 67±8 years. The distance walked on the 2MWT had a mean of 157 ± 22 meters. The SBPmmHg Pre-Test 112±21 vs 131±15 Post-Test (p=0.24) and 119±22 at Recovery (p = 0.34) and HR (bpm) Pre-Test 75±15 vs 89±19 Post-Test (p=0.15) and 79±15 at Recovery (p = 0.59). After a rest, all variables analyzed followed the same pattern, returning to values close to the pre-test moment. Conclusion The performance of the 2MWT in the hospital environment presents good feasibility in the evaluation of submaximal capacity in elderly patients after AMI. death AMI (AMI index twominute minute MWT (2MWT patient crosssectional cross sectional study discharge SBP, SBP , (SBP) DBP, DBP (DBP) SpO2, SpO2 SpO (SpO2) (HR DP (DP checked examiner moments 2 rest posttest post recovery p005 p 0 05 p<0.0 significant 5 80% 80 (80% 678 67 8 67± years 15 meters PreTest Pre Test 11221 112 21 112±2 13115 131 131±1 PostTest Post p=0.24 p024 24 (p=0.24 11922 119 119±2 0.34 034 34 bpm (bpm 7515 75 75±1 8919 89 19 89±1 p=0.15 p015 (p=0.15 7915 79 79±1 0.59. 059 0.59 . 59 0.59) pattern pretest moment (SBP (DBP (SpO2 p00 p<0. (80 6 1 1122 11 112± 1311 13 131± p=0.2 p02 (p=0.2 1192 119± 0.3 03 3 751 7 75± 891 89± p=0.1 p01 (p=0.1 791 79± 0.5 (SpO p0 p<0 (8 p=0. (p=0. 0. p< ( p=0 (p=0 p= (p=

Abstract Purpose: Since pain and symptoms related to the surgical wound are common in the postoperative period, it is essential to know about interventions to enable the patient to self-manage these symptoms. Objective: This review aimed to identify therapeutic guidelines to support the self-management of pain symptoms and those related to the surgical wound in people with oncological disease undergoing surgery, after clinical discharge. Methods: This review was guided by the Joanna Briggs Institute (JBI) methodology for scoping reviews and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) model for organizing information. The search strategy included studies in CINAHL and MEDLINE, via EBSCOhost. Results: The search identified 302 publications, from these, 8 studies were selected for pain and 4 for symptoms related to the surgical wound. Non-pharmacological interventions were the most frequently described and included physical and psychosocial interventions, related to pain. With regard to the surgical wound, interventions to monitor signs and symptoms indicative of infection are highlighted. Conclusions: Evidence indicates that postoperative pain control may benefit when pharmacological interventions are complemented with non-pharmacological interventions. Training for self-monitoring of the surgical wound, namely the early detection of signs of infection, is the main promoter for self-management.

Resumo Enquadramento: Sendo a dor e sintomas relacionados com a ferida cirúrgica comuns no período pós-operatório, é fundamental conhecer intervenções para capacitar o doente para a autogestão destes sintomas. Objetivo: Identificar as orientações terapêuticas de suporte à autogestão dos sintomas dor e relacionados com a ferida cirúrgica na pessoa com doença oncológica submetida a cirurgia, após alta clínica. Metodologia: Esta revisão foi guiada pela metodologia da Joanna Briggs Institute (JBI) para scopings reviews e pelo modelo PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) para organização da informação. A estratégia de pesquisa incluiu estudos nas bases de dados CINAHL e MEDLINE, via EbscoHost. Resultados: Foram identificadas 302 publicações e, destas, foram selecionados 8 estudos para a dor e 4 para sintomas relacionados com a ferida cirúrgica. As intervenções não farmacológicas foram as mais frequentemente descritas e incluíram intervenções do tipo físico e psicossocial, para o sintoma dor. Relativamente à ferida cirúrgica, salientam-se as intervenções de monitorização de sinais e sintomas indicativos de infeção. Conclusão: A evidência indica que o controlo da dor pós-operatória pode beneficiar quando se complementam intervenções farmacológicas com intervenções não farmacológicas. A capacitação para a automonitorização da ferida cirúrgica, nomeadamente a deteção precoce de sinais de infeção, é o principal promotor para a sua autogestão.

Abstract Background: According to the literature 58.7% to 86.7% of hospitalized patients have a peripheral venous catheter. However, the use of this device is not without complications. The management of these devices generates a significant demand for care by the nursing team. Objective: Construct and validate a scale to determine the time interval for the evaluation of peripheral accesses using continuous infusion in pediatrics. Methodology: Methodological, observational, prospective, quantitative and convergent assistential study. Results: The scale was submitted to two phases for construct validation. The final sum of all scores had an agreement of 87.5%. The Linear Weighted Kappa Reliability Test showed almost perfect reliability 0.91, 0.87 and 0.88 for patient’s clinical condition, vein characteristics and final score respectively. All indicators were statistically significant (p = 0.001). Conclusion: The time interval for the evaluation of peripheral accesses in continuous infusion, considering the specificity of each patient, is possible using the Maia e Castro scale, which helps the practice of nursing care in pediatric patients.

Marco contextual: Según la bibliografía, entre el 58,7% y el 86,7% de los pacientes hospitalizados tienen un catéter venoso periférico. Sin embargo, el uso de este dispositivo no está exento de complicaciones. La gestión de estos dispositivos genera una importante necesidad de cuidados por parte del equipo de enfermería. Objetivo: Construir y validar una escala para determinar el intervalo de tiempo para evaluar los accesos periféricos mediante infusión continua en pediatría. Metodología: Estudio metodológico, observacional, prospectivo, cuantitativo y convergente asistencial. Resultados: La escala se sometió a dos fases de validación de constructo. La suma final de todas las puntuaciones mostró una concordancia del 87,5%. La prueba de fiabilidad Kappa lineal ponderada indicó una fiabilidad casi perfecta de 0,91, 0,87 y 0,88 para el estado clínico del paciente, las características de las venas y la puntuación final, respectivamente. Todos los indicadores fueron estadísticamente significativos (p = 0,001). Conclusión: El intervalo de tiempo para evaluar los accesos periféricos en infusión continua, teniendo en cuenta la especificidad de cada paciente, es posible utilizando la Escala de Maia y Castro, que ayuda a la práctica de los cuidados de enfermería en la población pediátrica.

Resumo Enquadramento: Segundo a literatura 58,7% a 86,7% dos pacientes hospitalizados têm um cateter venoso periférico. Contudo, a utilização desse dispositivo não é isenta de complicações. A gestão desses dispositivos gera uma necessidade significativa de cuidados pela equipa de enfermagem. Objetivo: Construir e validar uma escala para determinar o intervalo tempo para a avaliação dos acessos periféricos em uso de infusão contínua em pediatria. Metodologia: Estudo, metodológico, observacional, prospetivo, quantitativo e convergente assistencial. Resultados: A escala foi submetida a duas fases para validação de constructo. A somatória final de todos os scores teve concordância de 87,5%. O Teste de confiabilidade de Kappa Ponderado Linear apontou confiabilidade quase perfeita 0,91, 0,87 e 0,88 para a condição clínica do paciente, características das veias e a pontuação final, respetivamente. Todos os indicadores foram estatisticamente significativos (p = 0,001). Conclusão: O intervalo de tempo para avaliação dos acessos periféricos em infusão contínua considerando a especificidade de cada paciente é possível utilizando a Escala Maia e Castro que auxilia a prática da assistência do enfermeiro na população pediátrica.