Abstract Background Psoriasis represents a chronic inflammatory phenotype shaped by genetic interactions, characterized by keratinocyte hyperproliferation and commonly affecting the skin and joints. Experimental and clinical studies suggest that the IL-17F gene locus plays a role as a central cytokine in the immunopathogenesis of psoriasis. Objectives Based on the central role of IL-17F in the pathogenesis of psoriasis, the authors thought that variations in this gene could affect the susceptibility and severity of this disease. Therefore, in this study, the authors aimed to analyze whether the IL-17F rs763780 variant has an effect on psoriasis pathogenesis in the Turkish population. Method In this case-control study, the study group consisted of 603 people (201 psoriasis patients (73 males/128 females)/402 controls (146 males/256 females) were genotyped in terms of IL-17F rs763780 polymorphism with TaqMan 5' Allelic Discrimination Test. Results The genotype distributions of the IL-17F rs763780 polymorphism between patients and control groups were statistically different, and the TC (heterozygous genotype) and CC (homozygous mutant genotype) genotypes were more represented in the patients group than in the control group (24.9% vs. 10.2%; 2.0% vs. 0.2%, respectively). In addition, the variant C allele was higher in the patients group and this was statistically significant (p < 0.001), and the C allele carriage was associated with a 3.14-fold increased risk of psoriasis (95% CI 2.015‒24.921). Study limitations The present study has some limitations. The first limitation is the relatively small sample size. The second limitation is that the authors could not measure IL-17F expression levels. However, the present study data draw attention to the importance of IL-17F which deserves to be studied in a larger sample group. Conclusion We report that IL-17F rs763780 TC and CC genotype and C allele are associated with an increased risk of psoriasis in the Turkish population. interactions joints IL17F ILF IL 17F F disease Therefore rs rs76378 population casecontrol case 60 201 (20 73 (7 males128 males 128 males/12 females/402 females402 females /402 402 females)/40 146 (14 males256 256 males/25 5 Test different heterozygous homozygous 24.9% 249 24 9 (24.9 vs 10.2% 102 10 2 20 0 2.0 02 0.2% respectively. respectively . respectively) addition p 0.001, 0001 0.001 , 001 0.001) 3.14fold 314fold fold 3.14 3 14 95% 95 (95 2.015‒24.921. 201524921 2.015‒24.921 015 921 2.015‒24.921) size levels However rs7637 6 (2 7 ( males12 12 males/1 females/40 females40 /40 40 females)/4 (1 males25 25 males/2 24.9 (24. 10.2 1 2. 0.2 000 0.00 00 14fold 314 3.1 (9 20152492 2.015‒24.92 01 92 rs763 males1 males/ females/4 females4 /4 4 females)/ males2 24. (24 10. 0. 0.0 31 3. 2015249 2.015‒24.9 rs76 females/ / 201524 2.015‒24. rs7 20152 2.015‒24 2015 2.015‒2 2.015‒ 2.015 2.01