Resumo Um homem de 35 anos, com hipertireoidismo, relatou a ocorrência repentina de lesões orais ulceradas e dolorosas, lesões ulcerativas-necróticas dolorosas na face, tronco, membros superiores e inferiores e lesões circinadas purpúricas no couro cabeludo, seis dias após início do tratamento com iodo oral. A história clínica, as lesões cutâneo-mucosas e os achados histopatológicos apoiam o diagnóstico de iododerma secundária ao tratamento oral com iodo. O iododerma é uma doença rara causada pela exposição ao iodo, desenvolvida após o uso oral ou intravenoso ou, raramente, após o uso tópico de iodo e muitas vezes está associada a manifestações sistêmicas relacionadas à vasculite, que podem ser fatais, como no presente caso.

Abstract A 35-year-old man with hyperthyroidism reported the sudden occurrence of ulcerated and painful oral lesions, painful ulcerative-necrotic lesions on the face, trunk, upper and lower limbs and purpuric circinate lesions on the scalp, 6 days after starting the treatment with oral iodine. The clinical history, cutaneous-mucosal lesions, and histopathological findings support the diagnosis of iododerma secondary to oral iodine treatment. Iododerma is a rare disease caused by iodine exposure that can develop after oral or intravenous use, rarely after topical use of iodine and is often associated with systemic manifestations related to vasculitis, which can be fatal, as in the present case.

Abstract Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis herpetiformis, whose multiple biopsies were inconclusive, and only after direct immunofluorescence with a pemphigus pattern (intraepidermal intercellular pattern) the confirmation of the diagnosis was possible.

Abstract Lichen planus is a chronic inflammatory disease that affects the skin, mucous membranes, nails and scalp. Esophageal lichen planus is a rarely reported manifestation of lichen planus, presenting itself commonly in middle-aged women, with symptoms such as dysphagia. We report a case of esophageal lichen planus in a 54-year-old woman associated with oral, cutaneous and ungual lichen planus. Although lichen planus is a disorder well known by dermatologists, reports of esophageal lichen planus are rare in dermatologic literature. The esophageal lichen planus is little known and underdiagnosed, with a significant delay between the onset of symptoms and diagnosis.

Os linfomas cutâneos primários têm comportamento clínico e prognóstico diferente dos linfomas sistêmicos de subtipo histológico semelhante. Cerca de 30% dos linfomas não-Hodgkin acometem tecidos extranodais, sendo a pele o segundo órgão mais envolvido após o trato gastrointestinal (aproximadamente 18%). De acordo com a classificação EORTC (European Organization for Research and Treatment of Cancer), o linfoma centrofolicular cutâneo é indolente, uma vez que as lesões aumentam de tamanho lentamente ao longo dos anos e a disseminação para sitios extracutâneos é incomum. Com base nisso, a radioterapia tem sido apontada como o tratamento de primeira escolha por muitos estudos. Apresentamos um caso de paciente com linfoma cutâneo centrofolicular no couro cabeludo há 1 ano e que apresentou boa resposta à radioterapia.

Primary cutaneous lymphomas have different clinical behavior and prognosis than systemic lymphomas of similar histological subtype. About 30% of non-Hodgkin lymphomas involve extranodal tissues, the skin being the second most affected body organ after the gastrointestinal tract (approximately 18%). According to the EORTC (European Organization for Research and Treatment of Cancer) classification, the lymphoma centrofollicular is indolent, since the lesions increase in size slowly over the years and spread to extracutaneous sites is uncommon. Based on this, radiotherapy has been considered the treatment of choice by many studies. We present the case of a patient who had cutaneous centrofollicular scalp lymphoma for 1 year and showed good response to radiotherapy.