A condensação do 3-formilcromano (1) com tiazolidina-2,4-diona (2) produziu 5-[4-oxo-4H-croman-3-ila)metileno]-1,3-tiazolidina-2,4-diona (3). A reação de 3 com hidrato de hidrazina, fenil hidrazina e hidrocloreto de hidroxilamina produziu os derivados correspondentes pirazol e isoxazol 4-7. O composto 3 reagiu com tiouréia, guanidina e cianoguanidina para produzir os derivados correspondentes de pirimidina 8-10. Pirimido[1,2-a]pirimidina 12, benzo[1,5]diazepina 15, pirido[1,2-b][1,2,3]triazepina 16, 1,2,4-triazolo[3,4-b][1,3,4]tiadiazepina 19 e 1,2,4-triazino[3,2-b][1,3,4]tiadiazepina 20 ligados à tiazolidina-2,4-diona foram preparados a partir da reação de 3 com nucleófilos bifuncionais N,N- e N,S-. A reatividade química de 3 frente aos nucleófilos carbonados produziu novos derivados heterocíclicos de tiazolidina-2,4-diona 22-25. Os compostos sintetizados foram testados in vitro para verificar sua atividade antimicrobiana contra Staphylococcus aureus, Proteus vulgaris e Candida albicans
Condensation of 3-formylchromone (1) with thiazolidine-2,4-dione (2) afforded 5-[4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-2,4-dione (3). Reaction of 3 with hydrazine hydrate, phenyl hydrazine and hydroxylamine hydrochloride gave the corresponding pyrazole and isoxazole derivatives 4-7. Compound 3 was subjected to react with thiourea, guanidine and cyanoguanidine to give the corresponding pyrimidine derivatives 8-10. Pyrimido[1,2-a]pyrimidine 12, benzo[1,5]diazepine 15, pyrido[1,2-b][1,2,4]triazepine 16, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazepine 19 and 1,2,4-triazino[3,2-b][1,3,4]thiadiazepine 20 linked thiazolidine-2,4-dione were prepared from the reaction of 3 with N,N- and N,S- bifunctional nucleophiles. The chemical reactivity of 3 towards carbon nucleophiles gave new heterocyclic moieties linked thiazolidine-2,4-dione 22‑25. The synthesized compounds were screened in vitro for their antimicrobial activities against Staphylococcus aureus, Proteus vulgaris and Candida albicans.