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Abstract Background: Endotracheal intubation (ETI), which is the gold standard in coronary artery bypass grafting (CABG), may cause myocardial ischaemia by disturbing the balance between haemodynamic changes and oxygen supply and consumption of the myocardium as a result of sympathetic stimulation. In this study, we aimed to compare two different videolaryngoscopes (C-MAC and Airtraq) in the hemodynamic response to ETI. Methods: Fifty ASA II-III CABG surgery patients were randomly assigned to C-MAC or Airtraq. The hemodynamic data included arterial blood pressure [systolic (SAP), diastolic (DAP) and mean (MAP)] and heart rate (HR) and were recorded at six different points in time: before laryngoscopy-T1, during laryngoscopy-T2, immediately after intubation-T3, and 3 (T4), 5 (T5) and 10 (T6) minutes after intubation. Intraoperative complications were recorded. Patients were questioned about postoperative complications 2 and 24hours following extubation. Results: The hemodynamic response to ETI was significantly greater with C-MAC. The increase in HR started with the laryngoscopy procedure, whereas increases in SAP, DAP, and MAP started immediately after ETI (p = 0.024; p = 0.012; p = 0.030; p = 0.009, respectively). In group analyses, T1-T2, T2-T3 and T1-T3 comparisons did not show any significant differences in HR with Airtraq. However, with C-MAC, HR after intubation increased significantly compared to the pre-laryngoscopy values (T1-T3) (p = 0.004). The duration of laryngoscopy was significantly reduced with C-MAC (p < 0.001), but the duration of intubation and total intubation were similar (p = 0.36; p = 0.79). Conclusions: Compared to C-MAC, the hemodynamic response to ETI was less with Airtraq. Thus, Airtraq may be preferred in CABG patients for ETI. Background ETI, , (ETI) CABG, (CABG) stimulation study CMAC C MAC Methods IIIII II III systolic SAP (SAP) DAP (DAP (MAP) (HR time laryngoscopyT1, laryngoscopyT1 laryngoscopyT T1, T1 T laryngoscopy-T1 laryngoscopyT2, laryngoscopyT2 T2, T2 laryngoscopy-T2 intubationT3, intubationT3 intubationT T3, T3 intubation-T3 T4, T4 (T4) T5 (T5 1 T6 (T6 hours extubation Results CMAC. MAC. procedure 0.024 0024 0 024 0.012 0012 012 0.030 0030 030 0009 009 0.009 respectively. respectively . respectively) analyses T1T2, T1T2 TT T1-T2 T2T3 T2-T T1T3 T1-T However CMAC, MAC, prelaryngoscopy pre (T1-T3 0.004. 0004 0.004 004 0.004) 0.001, 0001 0.001 001 0.001) 0.36 036 36 0.79. 079 0.79 79 0.79) Conclusions Thus (ETI (CABG (SAP (MAP laryngoscopy-T intubation-T (T4 (T 0.02 002 02 0.01 01 0.03 003 03 000 00 0.00 T1T T2T (T1-T 0.3 07 0.7 7 0.0 0.