ABSTRACT Purpose: The prevalence of ocular allergy varies according to the population and location of the study. Severe forms of ocular allergy are associated with compromised quality of life. In this study, we aimed to evaluate the application of the Brazilian-Portuguese version of the Quality of Life in Children with Keratoconjunctivitis questionnaire to children and adolescents with different subtypes of allergic conjunctivitis. Method: A total of 48 patients (aged 5-12 years) with allergic conjunctivitis were included in this study. They were enrolled and monitored at a specialized center. After the clinical appointment, the children responded to the questionnaire on two occasions at an interval of 30 days. Individual scores (ranging from 0 to 3) of the 16 items were added. Results: The Brazilian-Portuguese version of the Quality of Life in Children with Keratoconjunctivitis questionnaire demonstrated good translation, adaptation, and intellectual properties, with substantial internal consistency (Cronbach’s α coefficient = 0.702). There was no significant difference between the responses of the two interviews, revealing good reproducibility. The moderate/severe forms of allergic conjunctivitis had significantly higher quality of life scores (indicating a poorer quality of life) than the mild forms. Conclusions: The Brazilian-Portuguese version of the Quality of Life in Children with Keratoconjunctivitis proved to be quick, reliable, and reproducible for assessing the quality of life in children with allergic conjunctivitis. However, its ability to detect changes resulting from symptom aggravation or treatment needs to be further evaluated. Purpose study BrazilianPortuguese Brazilian Portuguese Method 4 aged 512 5 12 5-1 years center appointment 3 days ranging 1 added Results translation adaptation properties Cronbachs Cronbach s 0.702. 0702 0.702 . 702 0.702) interviews reproducibility moderatesevere moderate severe indicating Conclusions quick reliable However evaluated 51 5- 070 0.70 70 07 0.7 7 0.

Abstract Objectives To assess the prevalence and pattern of behavioral problems in children and adolescents with atopic dermatitis (AD) and to study their associations with clinical data and severity. Methods This was a single-center, cross-sectional study of patients (6-17 years) with AD. Assessment of competencies and syndrome scale scores of behavioral problems was performed by applying the Child Behavior Checklist 6-18 (CBCL 6-18) and AD severity using the Eczema Area Severity Index (EASI) score. Results Of the 100 patients with AD, 56% were male, with a mean age of 11±3 years, and 43% had moderate/severe AD. Borderline or abnormal values were found in 75% of the patients for total social competence, 57% for internalization, 27% for externalization, and 18% for aggressive behavior. A higher prevalence of aggressive behavior (27.9% vs. 10.5%; p= 0.02) and sleep disorders (32.6% vs. 15.8%; p= 0.04) was observed in patients with moderate/severe AD than in those with mild AD. Children with current or previous use of immunosuppressants/immunobiological tests had a lower frequency of normal social competence (53% vs. 83%, p= 0.012). Regarding the critical questions, 8% responded affirmatively to suicidal ideation. Conclusion A high prevalence of behavioral problems was observed among children and adolescents with AD, with a predominance of internalizing profiles, mainly anxiety and depression. Children with moderate/severe AD have a higher prevalence of aggressive behaviors and sleep disorders. These findings highlight the importance of multidisciplinary teams, including mental health professionals, in caring for patients with AD. (AD singlecenter, singlecenter single center, center single-center crosssectional cross sectional 617 6 17 (6-1 years 618 18 6-1 CBCL EASI (EASI score 10 56 male 113 11 3 11± 43 moderatesevere moderate severe 75 57 internalization 27 externalization 27.9% 279 9 (27.9 vs 10.5% 105 5 p 0.02 002 0 02 32.6% 326 32 (32.6 15.8% 158 15 8 0.04 004 04 immunosuppressantsimmunobiological immunosuppressants immunobiological 53% 53 (53 83 83% 0.012. 0012 0.012 . 012 0.012) questions ideation profiles depression teams professionals 61 1 (6- 6- 4 7 2 27.9 (27. 10.5 0.0 00 32.6 (32. 15.8 (5 001 0.01 01 (6 27. (27 10. 0. 32. (32 15. ( (2 (3

Abstract Objective Evaluate biomarkers capable of safely guiding Yellow fever vaccine (YFV) vaccination among individuals suspicious of hen's egg allergy, and identify factors associated with a higher risk for adverse events after immunization (AEAI). Methods Patients underwent skin prick test (SPT) for standardized allergens: whole egg, egg white, egg yolk; YFV (1:10 dilution; Biomanguinhos-Fiocruz), and intradermal test (IDT; YFV 0.02 mL, 1:100 dilution) and positive and negative controls. Serum levels of specific IgE (sIgE) for a whole egg, egg white, egg yolk, egg albumin, ovomucoid, lysozyme, and conalbumin (ImmunoCap®; ThermoFisher®) were obtained. Patients sensitized to YFV were submitted to YFV desensitization, and those negatives received YFV (0.5mL) and remained under surveillance for at least one hour. Results 103 patients were enrolled, 95% under 12 years old. 71% (81/103) of patients had reactions: 80% immediate, 11% mixed, and 9% delayed. There was an association between positive skin test results with YFV and the severity of the reaction (OR:7.64; 95%CI:1.61-36.32; p =0,011). Only the presence of sIgE to ovomucoid was associated with clinical symptoms (p =0,025). Thirty patients underwent the YFV desensitization protocol. Conclusion There is a relationship between the positivity of the egg's components and the severity of the clinical reaction. Furthermore, the relationship between the positivity of the tests with the YFV and egg's components may show a tendency to look at ovomucoid and conalbumin, but it is not a certainty. Therefore, further studies are needed to confirm these associations, and for now, the authors still recommend using the vaccine for testing when necessary. (YFV hens hen s allergy AEAI. AEAI . (AEAI) SPT (SPT allergens white yolk 110 1 10 (1:1 dilution BiomanguinhosFiocruz, BiomanguinhosFiocruz Biomanguinhos Fiocruz , Biomanguinhos-Fiocruz) IDT (IDT 002 0 02 0.0 mL 1100 100 1:10 controls (sIgE albumin lysozyme ImmunoCap® ImmunoCap (ImmunoCap® ThermoFisher® ThermoFisher obtained 0.5mL 05mL 5mL (0.5mL hour enrolled 95 old 71 81/103 81103 81 (81/103 reactions 80 immediate 11 mixed 9 delayed OR7.64 OR764 OR 7.64 7 64 (OR:7.64 95%CI1.6136.32 95CI1613632 CI 95%CI 1.61 36.32 61 36 32 95%CI:1.61-36.32 =0,011. 0011 =0,011 011 =0,011) =0,025. 0025 =0,025 025 =0,025) protocol eggs Furthermore certainty Therefore associations now necessary (AEAI (1: Biomanguinhos-Fiocruz 00 0. 1:1 (ImmunoCap 81/10 8110 8 (81/10 OR7 OR7.6 OR76 764 7.6 6 (OR:7.6 CI1 6136 95%CI1.6136.3 95CI161363 95CI 161 1.6 3632 36.3 3 95%CI:1.61-36.3 001 =0,01 01 =0,02 (1 1: 81/1 811 (81/1 OR7. 76 7. (OR:7. 613 95%CI1.6136. 95CI16136 16 1. 363 36. 95%CI:1.61-36. =0,0 ( 81/ (81/ (OR:7 95%CI1.6136 95CI1613 95%CI:1.61-36 =0, (81 (OR: 95%CI1.613 95CI161 95%CI:1.61-3 =0 (8 (OR 95%CI1.61 95CI16 95%CI:1.61- = 95%CI1.6 95CI1 95%CI:1.61 95%CI1. 95%CI:1.6 95%CI1 95%CI:1. 95%CI:1 95%CI:

Abstract The interaction between genetic potential and the environment, especially increased urbanization and inadequate waste management, contributes to the manifestation of allergic diseases. Pediatric patients are the most vulnerable, due to the immaturity of the respiratory and immune systems. Prenatal and postnatal exposure to air pollutants, both indoors and outdoors, accelerates or aggravates morbidity and mortality from allergic diseases. The “exposome,” which encompasses all environmental exposures throughout life, influences health. Biological and chemical attacks alter the epithelial barrier, triggering inflammatory responses and favoring allergic diseases, such as food allergies. The uncontrolled use of toxic fuels, particulate matter, detergents and other factors contribute to the continuous deterioration of the intestinal epithelial barrier, increasing the risk of allergic diseases. It is important to take urgent action to address these issues and protect the health of the planet.

Resumen La interacción entre el potencial genético y el medio ambiente, especialmente el aumento de la urbanización y la gestión inadecuada de residuos contribuye con la manifestación de enfermedades alérgicas. Los pacientes pediátricos son los más vulnerables, debido a la inmadurez de los sistemas respiratorio e inmunológico. La exposición prenatal y posnatal a contaminantes del aire, tanto en exteriores como interiores, acelera o agrava la morbilidad y mortalidad por enfermedades alérgicas. El "exposoma", que abarca todas las exposiciones ambientales a lo largo de la vida, influye en la salud. Las agresiones biológicas y químicas alteran la barrera epitelial, desencadenando respuestas inflamatorias y favoreciendo enfermedades alérgicas, como alergias alimentarias. El uso descontrolado de combustibles tóxicos, material particulado, detergentes y otros factores contribuyen con el deterioro continuo de la barrera epitelial intestinal, aumentando el riesgo de enfermedades alérgicas. Es importante tomar medidas urgentes para abordar estos problemas y proteger la salud del planeta.

RESUMEN Introducción. La salud ambiental infantil es la rama de la pediatría que estudia la influencia del medioambiente en la salud y la enfermedad de los niños. Las exposiciones ambientales globales representan una seria amenaza para la salud, lo que justifica una mayor investigación y acción. Objetivo. Evaluar la salud ambiental de una muestra de niños que viven en áreas urbanas y rurales de la ciudad de Uruguaiana, Brasil. Población y métodos. Se incluyeron padres/tutores (n = 714) de niños atendidos en el Policlínico Infantil de la Ciudad de Uruguaiana de enero a octubre de 2021, que respondieron la anamnesis ambiental en pediatría (Sociedad Brasileña de Pediatría). Los datos obtenidos se analizaron según la residencia en zona urbana o rural, o el ingreso familiar. Resultados. Al comparar los habitantes de la zona urbana (n = 660) con los de la zona rural (n = 54), verificamos que entre los de la zona rural fue significativamente mayor la actividad con productos químicos (15 % vs. 32,7 %; p = 0,004), vivir cerca de plantación (7,5 % vs. 74,5 %; p <0,001) o con fuente de contaminación (4,8 % vs. 32,7 %; p <0,001), tener perro (62 % vs. 87,3 %; p <0,001), usar plaguicidas (0,6 % vs. 32,7 %; p <0,001) y exposición a contaminación química (2,6 % vs. 18,2 %; p <0,001). En el área urbana predominó la exposición al tránsito de vehículos cerca de la vivienda (85 % vs. 48,1 %; p <0,001), renta media inferior a 3 salarios mínimos (90 %) y baja escolaridad. Conclusión. Realizar la anamnesis ambiental es fundamental para la detección de amenazas ambientales presentes en los lugares donde los niños y adolescentes viven, aprenden, juegan y estudian.

Abstract Objectives: Since the beginning of its use for the prevention of tuberculosis (TB) in 1921, other uses of BCG (Bacillus Calmette-Guérin) have been proposed, particularly in the treatment of malignant solid tumors, multiple sclerosis, and other autoimmune diseases. Its beneficial impact on other infections, by nontuberculous mycobacteria, and by viruses, has been more often studied in recent years, especially after the introduction of the concept of trained immunity. The present study’s objective was to review the possible indications of BCG and the immunological rationale for these indications. Data source: Non-systematic review carried out in the PubMed, SciELO and Google Scholar databases, using the following search terms: “BCG” and “history”, “efficacy”, “use”, “cancer”, “trained immunity”, “other infections”, “autoimmune diseases”. Data synthesis: There is epidemiological evidence that BCG can reduce overall child morbidity/mortality beyond what would be expected from TB control. BCG is able to promote cross-immunity with nontuberculous mycobacteria and other bacteria. BCG promotes in vitro changes that increase innate immune response to other infections, mainly viral ones, through mechanisms known as trained immunity. Effects on cancer, except bladder cancer, and on autoimmune and allergic diseases are debatable. Conclusions: Despite evidence obtained from in vitro studies, and some epidemiological and clinical evidence, more robust evidence of in vivo efficacy is still needed to justify the use of BCG in clinical practice, in addition to what is recommended by the National Immunization Program for TB prevention and bladder cancer treatment. Objectives (TB 1921 Bacillus CalmetteGuérin Calmette Guérin Calmette-Guérin proposed tumors sclerosis infections viruses years immunity studys study s source Nonsystematic Non systematic PubMed databases terms “BCG history, history , “history” efficacy, “efficacy” use, “use” “cancer” immunity, immunity” infections” . diseases” synthesis morbiditymortality morbidity mortality control crossimmunity cross bacteria ones debatable Conclusions studies practice 192 “history “efficacy “use “cancer 19 1

Abstract Objective: Through a literature review, make recommendations regarding immunizations in people living with Inborn Error of Metabolism (IEM) in Brazil, assess the possible impact on metabolic decompensations after immunization, and if this specific population may have an impaired immune response to vaccines. Source of data: The MeSH Terms vaccination OR vaccine OR immunization associated with the term inborn error of metabolism AND recommendation were used in combination with search databases. Only articles published after 1990, in the languages English, Spanish, French or Portuguese, human-related were included. Synthesis of data: A total of 44 articles were included to make the following recommendations. Individuals with IEMs need to be up to date with their immunizations. Regarding which vaccines should be offered, children and adults should follow the routine immunization schedules locally available, including the COVID-19 vaccines. The only exception is the rotavirus vaccine for hereditary fructose intolerance. The benefit of immunization outweighs the very low risk of metabolic decompensation. Since not all patients will have an adequate immune response, measuring antibody conversion and titers is recommended Conclusions: All patients should receive age-appropriate immunizations in their respective schedules without delays. The only situation when vaccination may be contraindicated is with oral rotavirus vaccine in hereditary fructose intolerance. Monitoring the levels of antibodies should be done to detect any immune dysfunction or the necessity for boosters. A personalized immunization schedule is ideal for patients with IEMs. The reference organizations could improve their recommendations to address all IEMs, not only some of them. Objective review IEM (IEM Brazil data databases 1990 English Spanish Portuguese humanrelated human related 4 offered available COVID19 COVID 19 COVID-1 intolerance decompensation Conclusions ageappropriate age appropriate delays boosters them 199 COVID1 1 COVID-

Abstract Objective: To determine the prevalence of allergic rhinitis and associated factors in adolescents and in their parents/guardians. Methods: A cross-sectional study, applying a standardized and validated written questionnaire. Adolescents (13–14 years old; n=1,058) and their parents/guardians (mean age=42.1 years old; n=896) living in the city of Uruguaiana, southern Brazil, responded to the Global Asthma Network standard questionnaires. Results: The prevalence of allergic rhinitis in adolescents was 28.0%, allergic rhinoconjunctivitis, 21.3%, and severe forms of allergic rhinitis, 7.8%. In the adults, the prevalence of allergic rhinitis was 31.7%. Some associated factors with allergic rhinitis in adolescents include low physical exercise (OR 2.16; 95%CI 1.15–4.05), having only one older sibling (OR 1.94; 95CI 1.01–3.72) and daily meat consumption (OR 7.43; 95% CI 1.53–36.11). In contrast, consuming sugar (OR 0.34; 95%CI 0.12–0.93) or olive oil (OR 0.33; 95%CI 0.13–0 .81) once or twice a week, and eating vegetables daily (OR 0.39; 95%CI 0.15–0.99) were considered factors negatively associated. In adults, exposure to fungi at home (OR 5.25; 95%CI 1.01–27.22) and consumption of meat once or twice a week (OR 46.45; 95CI 2.12–1020.71) were factors associated with the medical diagnosis of allergic rhinitis, while low education (OR 0.25; 95%CI 0.07–0.92) was found to be a factor negatively associated. Conclusions: The prevalence of allergic rhinitis in adolescents is high, as well as its medical diagnosis in adults living in Uruguaiana. Environmental factors, especially food habits, were associated with findings in both groups. Objective parentsguardians parents guardians Methods crosssectional cross sectional study questionnaire 13–14 1314 13 14 (13–1 old n=1,058 n1058 n 1 058 mean age421 age 42 age=42. n=896 n896 896 Uruguaiana Brazil questionnaires Results 280 28 0 28.0% rhinoconjunctivitis 213 21 3 21.3% 78 7 8 7.8% 317 31 31.7% OR 2.16 216 2 16 95 1.15–4.05, 115405 1.15–4.05 , 15 4 05 1.15–4.05) 1.94 194 94 1.01–3.72 101372 01 72 7.43 743 43 1.53–36.11. 1533611 1.53–36.11 . 53 36 11 1.53–36.11) contrast 0.34 034 34 0.12–0.93 012093 12 93 0.33 033 33 0130 0.13– .81 81 0.39 039 39 0.15–0.99 015099 99 5.25 525 5 25 1.01–27.22 1012722 27 22 46.45 4645 46 45 2.12–1020.71 212102071 1020 71 0.25 025 0.07–0.92 007092 07 92 Conclusions high habits groups 13–1 131 (13– n=1,05 n105 age42 age=42 n=89 n89 89 28.0 21.3 7.8 31.7 2.1 9 11540 1.15–4.0 1.9 19 1.01–3.7 10137 7.4 74 153361 1.53–36.1 0.3 03 0.12–0.9 01209 013 0.13 .8 0.15–0.9 01509 5.2 52 1.01–27.2 101272 46.4 464 2.12–1020.7 21210207 102 0.2 02 0.07–0.9 00709 13– (13 n=1,0 n10 age4 age=4 n=8 n8 28. 21. 7. 31. 2. 1154 1.15–4. 1. 1.01–3. 1013 15336 1.53–36. 0. 0.12–0. 0120 0.1 0.15–0. 0150 5. 1.01–27. 10127 46. 2.12–1020. 2121020 10 0.07–0. 0070 (1 n=1, n1 age= n= 115 1.15–4 1.01–3 101 1533 1.53–36 0.12–0 012 0.15–0 015 1.01–27 1012 2.12–1020 212102 0.07–0 007 ( n=1 1.15– 1.01– 153 1.53–3 0.12– 0.15– 1.01–2 2.12–102 21210 0.07– 00 1.15 1.01 1.53– 0.12 0.15 2.12–10 2121 0.07 1.1 1.0 1.53 2.12–1 212 0.0 1.5 2.12– 2.12

Resumo Objetivo: Determinar a prevalência de rinite alérgica e fatores associados em adolescentes e em seus pais/responsáveis. Métodos: Estudo transversal, com aplicação de questionário escrito padronizado e validado. Adolescentes (13–14 anos; n=1.058) e seus pais/responsáveis (média de idade=42,1 anos; n=896) residentes na cidade de Uruguaiana, Sul do Brasil, responderam aos questionários padrão da Global Asthma Network. Resultados: A prevalência de rinite alérgica em adolescentes foi de 28,0%, a de rinoconjuntivite alérgica foi de 21,3% e a de formas graves de rinite alérgica, de 7,8%. Nos adultos, a prevalência de rinite alérgica foi de 31,7%. Alguns fatores associados à rinite alérgica em adolescentes incluem fazer pouco exercício físico (odds ratio — OR 2,16; intervalo de confiança — IC95% 1,15–4,05), ter apenas um irmão mais velho (OR 1,94; IC95% 1,01–3,72) e consumir carne diariamente (OR 7,43; IC95% 1,53–36,11). Por outro lado, consumir açúcar (OR 0,34; IC5% 0,12–0,93) ou azeite de oliva (OR 0,33 IC95% 0,13–0,81) uma ou duas vezes por semana e comer vegetais diariamente (OR 0,39; IC95% 0,15–0,99) foram considerados fatores associados negativamente. Em adultos, a exposição a fungos no domicílio (OR 5,25; IC95% 1,01–27,22) e o consumo de carne uma ou duas vezes por semana (OR 46,45; IC95 2,12–1020,71) foram fatores associados ao diagnóstico médico de rinite alérgica, enquanto a baixa escolaridade (OR 0,25; IC95% 0,07–0,92) se mostrou como fator associado negativamente. Conclusões: A prevalência de rinite alérgica em adolescentes é alta, assim como seu diagnóstico médico em adultos residentes em Uruguaiana. Fatores ambientais, especialmente hábitos alimentares, foram associados aos achados em ambos os grupos. Objetivo paisresponsáveis pais responsáveis Métodos transversal validado 13–14 1314 13 14 (13–1 anos n=1.058 n1058 n 1 058 média idade421 idade 42 idade=42, n=896 n896 896 Uruguaiana Brasil Network Resultados 280 28 0 28,0% 213 21 3 21,3 78 7 8 7,8% 317 31 31,7% odds 2,16 216 2 16 IC 1,15–4,05, 115405 1,15–4,05 , 15 4 05 1,15–4,05) 1,94 194 94 1,01–3,72 101372 01 72 7,43 743 43 1,53–36,11. 1533611 1,53–36,11 . 53 36 11 1,53–36,11) lado 0,34 034 34 IC5 0,12–0,93 012093 12 93 033 33 0,3 0,13–0,81 013081 81 0,39 039 39 0,15–0,99 015099 99 negativamente 5,25 525 5 25 1,01–27,22 1012722 27 22 46,45 4645 46 45 IC9 2,12–1020,71 212102071 1020 71 0,25 025 0,07–0,92 007092 07 92 Conclusões alta ambientais alimentares grupos 13–1 131 (13– n=1.05 n105 idade42 idade=42 n=89 n89 89 28,0 21, 7,8 31,7 2,1 11540 1,15–4,0 1,9 19 9 1,01–3,7 10137 7,4 74 153361 1,53–36,1 03 0,12–0,9 01209 0, 0,13–0,8 01308 0,15–0,9 01509 5,2 52 1,01–27,2 101272 46,4 464 2,12–1020,7 21210207 102 0,2 02 0,07–0,9 00709 13– (13 n=1.0 n10 idade4 idade=4 n=8 n8 28, 7, 31, 2, 1154 1,15–4, 1, 1,01–3, 1013 15336 1,53–36, 0,12–0, 0120 0,13–0, 0130 0,15–0, 0150 5, 1,01–27, 10127 46, 2,12–1020, 2121020 10 0,07–0, 0070 (1 n=1. n1 idade= n= 115 1,15–4 1,01–3 101 1533 1,53–36 0,12–0 012 0,13–0 013 0,15–0 015 1,01–27 1012 2,12–1020 212102 0,07–0 007 ( n=1 1,15– 1,01– 153 1,53–3 0,12– 0,13– 0,15– 1,01–2 2,12–102 21210 0,07– 00 1,15 1,01 1,53– 0,12 0,13 0,15 2,12–10 2121 0,07 1,1 1,0 1,53 0,1 2,12–1 212 0,0 1,5 2,12– 2,12

Abstract Objective: To develop, validate, and test the reproducibility of a new test capable of assessing functional performance in children and adolescents (PAY test: Performance Activity in Youth). Methods: participants without and with asthma were included in the development and validation phases, respectively. The PAY test includes five activities: transition from sitting to standing, walking 10 m, step climbing, shoulder extension and flexion, and star jumps. Participants underwent the Pediatric Glittre test (TGlittre-P test time), modified shuttle test (MST), and cardiopulmonary exercise test (CPET). Outcomes: PAY test and TGlittre-P test times, oxygen uptake (VO2peak), and distance walked in the MST. Results: 8 healthy volunteers, aged 12 (7 -15) years old were included in the development phase and 34 participants with asthma, aged 11 (7-14) years old, in the validation phase. The PAY test elicited greater physiological responses (VO2peak 33.5 ± 6.9 mL/kg) than the TGlittre-P (VO2peak: 27.4 ± 9.0 mL/kg), but lower than the MST (VO2peak: 48.9 ± 14.2 mL/kg) and CPET (VO2peak: 42.0 ± 8.8 mL/kg), p < .05. Moderate correlation between the PAY test time and the TGlittre-P time (r = 0.70, p < .001) and distance walked in the MST (r = -0.72, p < .001). The PAY test time was longer in participants with asthma than in healthy participants (3.1 [3.0 – 3.3] min vs. 2.3 [2.1 – 2.4 min]), p < .001.; and the test was reproducible (ICC 0.78, CI 95% 0.55-0.90, p < .001). Conclusions: The PAY test is a valid and reproducible tool for assessing functional performance in children and adolescents with asthma. Objective develop validate Youth. Youth . Youth) Methods phases respectively activities standing 1 m climbing flexion jumps TGlittreP TGlittre P time, , time) MST, (MST) CPET. (CPET) Outcomes times VO2peak, VO2peak VOpeak VO peak (VO2peak) Results volunteers 7 ( 15 -15 3 714 14 (7-14 335 33 5 33. 69 6 9 6. mL/kg mLkg mL kg 274 27 4 27. 90 0 9. mL/kg, 489 48 48. 142 2 14. 420 42 42. 88 8. 05 .05 r 070 70 0.70 .001 001 0.72, 072 72 -0.72 .001. 3.1 31 (3. 3.0 30 [3. 3.3 vs 23 2. 2.1 21 [2. 24 min, min]) ICC 078 78 0.78 95 0.550.90, 055090 0.55 0.90, 55 0.55-0.90 Conclusions (MST (CPET -1 71 (7-1 .0 07 0.7 .00 00 0.72 -0.7 3. (3 [3 [2 min] 550 0.550.90 05509 055 0.5 090 0.90 0.55-0.9 - (7- 0. -0. [ 0.550.9 0550 09 0.9 0.55-0. -0 0.550. 0.55-0 0.550 0.55-

ABSTRACT Exposure to radon can impact human health. This is a nonsystematic review of articles written in English, Spanish, French, or Portuguese published in the last decade (2013-2023), using databases such as PubMed, Google Scholar, EMBASE, and SciELO. Search terms selected were radon, human health, respiratory diseases, children, and adults. After analyzing the titles and abstracts, the researchers initially identified 47 studies, which were subsequently reduced to 40 after excluding reviews, dissertations, theses, and case-control studies. The studies have shown that enclosed environments such as residences and workplaces have higher levels of radon than those outdoors. Moreover, radon is one of the leading causes of lung cancer, especially in nonsmokers. An association between exposure to radon and development of other lung diseases, such as asthma and COPD, was also observed. It is crucial to increase public awareness and implement governmental control measures to reduce radon exposure. It is essential to quantify radon levels in all types of buildings and train professionals to conduct such measurements according to proven efficacy standards. Health care professionals should also be informed about this threat and receive adequate training to deal with the effects of radon on human health. health English Spanish French 20132023, 20132023 2013 2023 , (2013-2023) PubMed Scholar EMBASE SciELO diseases children adults abstracts 4 reviews dissertations theses casecontrol case outdoors Moreover cancer nonsmokers COPD observed standards 2013202 201 202 (2013-2023 201320 20 (2013-202 20132 2 (2013-20 (2013-2 (2013- (2013 (201 (20 (2 (

RESUMO A exposição ao radônio pode ter impacto na saúde humana. Esta é uma revisão não sistemática de artigos escritos em inglês, espanhol, francês ou português publicados na última década (2013-2023), utilizando bancos de dados como PubMed, Google Acadêmico, EMBASE e SciELO. Os termos de busca selecionados foram radônio, saúde humana, doenças respiratórias, crianças e adultos. Após a análise dos títulos e resumos, os pesquisadores inicialmente identificaram 47 estudos, que foram posteriormente reduzidos para 40 após a exclusão de revisões, dissertações, teses e estudos de caso-controle. Os estudos mostraram que ambientes fechados como residências e locais de trabalho apresentam maiores níveis de radônio do que ambientes externos. Além disso, o radônio é uma das principais causas de câncer de pulmão, especialmente em não fumates. Também foi observada associação entre exposição ao radônio e desenvolvimento de outras doenças pulmonares, como asma e DPOC. É crucial aumentar a conscientização do público e implementar medidas governamentais de controle para reduzir a exposição ao radônio. É fundamental quantificar os níveis de radônio em todos os tipos de edifícios e treinar profissionais para realizar essas medições segundo padrões de eficácia comprovada. Os profissionais de saúde também devem ser informados sobre essa ameaça e receber formação adequada para lidar com os efeitos do radônio na saúde humana. humana inglês espanhol 20132023, 20132023 2013 2023 , (2013-2023) PubMed Acadêmico SciELO respiratórias adultos resumos 4 revisões dissertações casocontrole. casocontrole caso controle. caso-controle externos disso pulmão fumates pulmonares DPOC comprovada 2013202 201 202 (2013-2023 201320 20 (2013-202 20132 2 (2013-20 (2013-2 (2013- (2013 (201 (20 (2 (

RESUMO A conjuntivite alérgica (CA) é uma condição frequente, debilitante e responsável por grande impacto econômico, proporcionalmente maior quando acomete crianças. Essas diretrizes foram desenvolvidas com base na literatura científica (PubMed/Medline) e na experiência de um Comitê de Especialistas composto por membros da Sociedade Brasileira de Oftalmologia Pediátrica, do Conselho Brasileiro de Oftalmologia, da Sociedade Brasileira de Pediatria e da Associação Brasileira de Alergia e Imunologia. A conjuntivite alérgica é considerada controlada quando os sintomas não são desconfortáveis ou estão presentes por dois dias na semana; o escore visual pela escala analógica é inferior a 5 e o grau de hiperemia conjuntival é de 0-1 pela escala de Efron. A conjuntivite alérgica deve ser classificada em leve, moderada, grave e com risco de perda visual para tratamento e frequência de monitoramento adequados. Esta diretriz orienta o diagnóstico, tratamento e monitoramento da conjuntivite alérgica pediátrica, considerando aspectos clínicos e demográficos das condições alérgicas no Brasil.

ABSTRACT Allergic conjunctivitis is an increasingly frequent condition with a higher prevalence in children. It can be debilitating and is responsible for a great economic burden. These guidelines were developed on the basis of the medical literature (PubMed/Medline database) and the experience of an Expert Committee composed of members of the Brazilian Society of Pediatric Ophthalmology, the Brazilian Council of Ophthalmology, the Brazilian Society of Pediatrics, and the Brazilian Association of Allergy and Immunology. Allergic conjunctivitis is considered to be controlled when the ocular symptoms are not uncomfortable or are present, at most, on 2 days a week; the visual analog scale score is below 5; and the degree of conjunctival hyperemia is graded 0 or 1 on the Efron scale. Allergic conjunctivitis should be classified as mild, moderate, severe, and vision-threatening for adequate treatment and monitoring of frequency. The present document is a guideline for diagnosing, treating, and monitoring pediatric allergic conjunctivitis considering the clinical and demographic aspects of allergic conditions in Brazil.

Abstract Objective: To analyze the impacts of climate change on the development of immature respiratory and immune systems in children. Source of data: The authors of the present study performed a non-systematic review of English, Spanish, and Portuguese articles published in the last five years in databases such as PubMed, EMBASE, and SciELO. The terms used were air pollution OR climate changes OR smoke, AND children OR health. Synthesis of data: The increase in the prevalence of some diseases, such as allergic ones, is attributed to the interactions between genetic potential and the environment. However, disordered growth combined with inadequate waste management has caused problems for the planet, such as heatwaves, droughts, forest fires, increased storms and floods, interference in food crops and their nutritional values, changes in the infectious disease pattern, and air pollution resulting from the continuous use of fossil fuels. Children, beings still in the development stage with immature respiratory and immune systems, are the primary victims of the climate crisis. Conclusions: The authors documented that prenatal and postnatal exposure to ambient air pollutants will accelerate or worsen the morbidity and mortality of many health conditions, including allergic diseases. Ambient air pollutants change the microbiota, interfere with the immune response, and take direct action on the skin and respiratory epithelium, which facilitates the penetration of allergens. Understanding how the children and adolescent health and well-being are affected by climate change is an urgent matter.

ABSTRACT Objective Investigate pulse wave velocity and central systolic blood pressure among pediatric population with chronic kidney disease. Methods In this cross-sectional study, 57 patients (61.4% male) aged 6.2 to 17.5 years old, 44 with nondialysis chronic kidney disease and 13 on chronic dialysis, were included in the analysis. The pulse wave velocity and the central systolic blood pressure were measured with an oscillometric device with an inbuilt ARC SolverⓇ algorithm and were compared with previously established percentiles. Results The prevalence of elevated pulse wave velocity was 21.1% (95%Cl: 11.4-33.9) and elevated central systolic blood pressure was 28.1% (95%CI: 17.0-41.5). According to the generalized linear model, there was a higher risk of elevated pulse wave velocity in patients undergoing chronic dialysis treatment than nondialysis chronic kidney disease patients (adjPR=4.24, 95%CI: 1.97-9.13, p=<0.001). Hypertensive patients (stage 2) had a higher risk of elevated pulse wave velocity than normotensive ones (adjPR=2.70, 95%CI: 1.05-6.95, p=0.040), as did patients younger than 12 years than the older patients (adjPR=2.95, 95%CI: 1.05-8.40, p=0.041). Hypertensive patients had a higher risk of elevated central systolic blood pressure than normotensives (adjPR=3.29, 95%Cl: 1.36-7.94), as did patients undergoing chronic dialysis treatment when comparing to nondialysis chronic kidney disease patients (adjPR=2.08, 95%Cl: 1.07-4.02). Conclusion Younger age, dialysis, and hypertension in children are independently associated with higher pulse wave velocity. Hypertension and dialysis are independently associated with higher central systolic blood pressure.