Abstract Introduction: The benefit of total arterial revascularization (TAR) in coronary artery bypass grafting (CABG) remains a controversial issue. This study sought to evaluate whether there is any difference on the long-term results of TAR and non-TAR CABG patients. Methods: The Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), Cochrane Central Register of Controlled Trials (CENTRAL/CCTR), Clinical Trials.gov, Scientific Electronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), and Google Scholar databases were searched for studies published by October 2020. Randomized clinical trials and observational studies with propensity score matching comparing TAR versus non-TAR CABG were included. Random-effects meta-analysis was performed. The current barriers to implementation of TAR in clinical practice and measures that can be used to optimize outcomes were reviewed. Results: Fourteen publications (from 2012 to 2020) involving a total of 22,746 patients (TAR: 8,941 patients; non-TAR: 13,805 patients) were included. The pooled hazard ratio (HR) for long-term mortality (over 10 years) was lower in the TAR group than in the non-TAR group (random effect model: HR 0.676, 95% confidence interval 0.586-0.779, P<0.001). There was evidence of low heterogeneity of treatment effect among the studies for mortality, and none of the studies had a particular impact on the summary result. The result was not influenced by age, sex, or comorbidities. We identified low risk of publication bias related to this outcome. Conclusion: This review found that TAR presents the best long-term results in patients who undergo CABG. Given that many patients are likely to benefit from TAR, its use should be encouraged. Introduction (TAR (CABG issue longterm long term nonTAR non Methods MEDLINE, MEDLINE , (MEDLINE) EMBASE, EMBASE (EMBASE) CENTRAL/CCTR, CENTRALCCTR CENTRAL/CCTR CENTRAL CCTR (CENTRAL/CCTR) Trialsgov gov Trials.gov SciELO, SciELO (SciELO) LatinoAmericana Latino Americana LILACS, LILACS (LILACS) 2020 included Randomeffects Random effects metaanalysis meta analysis performed reviewed Results 201 22746 22 746 22,74 8941 8 941 8,94 13805 13 805 13,80 (HR over 1 years random model 0676 0 676 0.676 95 0.5860.779, 05860779 0.586 0.779, 586 779 0.586-0.779 P<0.001. P0001 P P<0.001 . 001 P<0.001) age sex comorbidities outcome Conclusion encouraged (MEDLINE (EMBASE (CENTRAL/CCTR (SciELO (LILACS 202 20 2274 2 74 22,7 894 94 8,9 1380 80 13,8 067 67 0.67 9 5860 0.5860.779 0586077 0586 0.58 0779 0.779 58 77 0.586-0.77 P000 P<0.00 00 227 7 22, 89 8, 138 13, 06 6 0.6 0.5860.77 058607 058 0.5 077 0.77 5 0.586-0.7 P00 P<0.0 0. 0.5860.7 05860 05 07 0.7 0.586-0. P0 P<0. 0.5860. 0.586-0 P<0 0.5860 0.586- P<

Abstract Objective: To test the German Aortic Valve (GAV) score at our university hospital in patients undergoing isolated aortic valve replacement (AVR). Methods: A total of 224 patients who underwent isolated conventional AVR between January 2015 and December 2018 were included. Patients with concomitant procedures and transcatheter aortic valve implantation were excluded. Patients’ data were collected and analyzed retrospectively. Patients’ risk scores were calculated according to criteria described by GAV score. Sensitivity, specificity, and accuracy (area under the ROC curve [AUC]) were also calculated. The calibration of the model was tested by the Hosmer-Lemeshow method. Results: The mortality rate was 8.04% (18 patients). The patients’ mean age was 58.2±19.3 years and 25% of them were female (56 patients). Mean GAV score was 1.73±5.86 (min: 0.0; max: 3.53). The GAV score showed excellent discriminative capacity (AUC 0.925, 95% confidence interval 0.882-0.956; P<0.001). The cutoff “1.8” turned out to be the best discriminatory point with the best combination of sensitivity (88.9%) and specificity (75.7%) to predict operative death. Hosmer-Lemeshow method revealed a P-value of 0.687, confirming a good calibration of the model. Conclusion: The GAV score applies to our population with high predictive accuracy.

OBJETIVO: Descrever procedimento cirúrgico de anuloplastia concêntrica do anel mitral sem prótese, isolada ou associada à ressecção quadrangular com plicatura póstero-medial do anel mitral, e analisar os resultados imediatos e tardios obtidos. MÉTODO: Entre fevereiro de 1986 e fevereiro de 2001, realizamos 790 procedimentos abordando a valva mitral, 41 foram realizados em crianças e adolescentes menores de 20 anos (média de 9,7 anos). Vinte (48,7%) pacientes eram do sexo feminino e 21 (51,3%) do masculino. A doença reumática foi responsável pelas lesões em 92,6% dos casos e a degeneração mixomatosa em apenas 7,4%. No período pré-operatório, 22 (53,6%) pacientes estavam em classe funcional III e 19 (46,4%) em classe funcional IV, advindos de repetidos surtos de febre reumática, agravados pela desnutrição. A técnica cirúrgica utilizada foi a anuloplastia concêntrica, aplicada isoladamente ou em associação à ressecção quadrangular com plicatura póstero-medial. O curso do seguimento pós-operatório foi de 7 meses a 15 anos (3/2/1986 a 12/2/2001). RESULTADOS: A mortalidade hospitalar foi de 2,4%. Os pacientes receberam alta sem sopro sistólico de regurgitação mitral. Dois pacientes apresentaram, ao longo dos anos (4 e 11 anos), estenose mitral e necessitaram reoperação, um deles operado com dois anos de idade. Dois doentes foram reoperados para corrigir disfunção aórtica previamente abordada por plastia (12 e 18 meses após a primeira operação), morrendo e contribuindo para mortalidade tardia de 5%. CONCLUSÃO: Consideramos a técnica empregada um procedimento alternativo, válido, de aplicação preferencial em crianças e adolescentes, de fácil reprodução e de baixíssimo custo.

OBJECTIVE: To describe the mitral anuloplasty technique either in isolation or associated with posterior quadrantectomy and to analyze the immediate and late results in young patients. METHOD: Between February 1986 and February 2001, 790 mitral valve procedures were performed in our Institution including 41 annuloplaties in patients with ages ranging from 1 to 20 years (Mean age = 9.7 years). 51.7% were males. The main etiologies were rheumatic disease (92.6%) and myxomatous degeneration (7.4%). Twenty-two (53.6%) patients were preoperatively in functional class III (NYHA), and 19 (46.4%) in class IV (NYHA), some in course of rheumatic fever aggravated by malnutrition. The technique employed was concentric mitral annuloplasty either in isolation or associated with posterior quadrantectomy. The follow-up ranged from 7 months to 15 years. RESULTS: The hospital mortality rate was 2.4%. All patients were discharged without mitral regurgitation. Two patients coursed with mitral stenosis (after 4 and 11 years respectively) and valve replacement was needed. Two patients coursed with aortic insufficiency (after 12 and 18 months) and died after aortic valve replacement, contributing to a 5% late mortality rate. CONCLUSION: In conclusion, mitral annuloplasty without ring either in isolation or associated with posterior quadrantectomy is a safe, easily reproducible especially in young patients.