The coronavirus disease 2019 (covid-19) pandemic has caused a public health emergency worldwide. Risk, severity and mortality of the disease have been associated with non-communicable chronic diseases, such as diabetes mellitus. Accumulated evidence has caused great concern in countries with high prevalence of this morbidity, such as Brazil. This text shows the picture of diabetes in Brazil, followed by epidemiological data and explanatory hypothesis for the association between diabetes and covid-19. We emphasized how the burden of these two morbidities in a middleincome country has aggravated this pandemic scenario. The comprehension of this association and biological plausibility may help face this pandemic and future challenges.

ABSTRACT The coronavirus disease 2019 (covid-19) pandemic has caused a public health emergency worldwide. Risk, severity and mortality of the disease have been associated with non-communicable chronic diseases, such as diabetes mellitus. Accumulated evidence has caused great concern in countries with high prevalence of this morbidity, such as Brazil. This text shows the picture of diabetes in Brazil, followed by epidemiological data and explanatory hypothesis for the association between diabetes and covid-19. We emphasized how the burden of these two morbidities in a middle-income country has aggravated this pandemic scenario. The comprehension of this association and biological plausibility may help face this pandemic and future challenges.

ABSTRACT The coronavirus disease 2019 (covid-19) pandemic has caused a public health emergency worldwide. Risk, severity and mortality of the disease have been associated with non-communicable chronic diseases, such as diabetes mellitus. Accumulated evidence has caused great concern in countries with high prevalence of this morbidity, such as Brazil. This text shows the picture of diabetes in Brazil, followed by epidemiological data and explanatory hypothesis for the association between diabetes and covid-19. We emphasized how the burden of these two morbidities in a middle-income country has aggravated this pandemic scenario. The comprehension of this association and biological plausibility may help face this pandemic and future challenges.

ABSTRACT Objectives Western dietary pattern predisposes to weight gain, insulin resistance and cardiometabolic diseases. Promoting satiety via modifications in diet composition could be useful to fight weight gain. Mediterranean diet which is recognized to be cardioprotective contains high fiber and unsaturated fat contents. We compared the effects of distinct breakfast patterns on satiety of individuals at cardiometabolic risk, and examined the correlation of satiety level after each breakfast intervention period with glucose parameters. Materials and methods In this 10-week cross-over clinical trial, 54 individuals with weight excess were submitted to 2 types of 4-week isocaloric breakfasts (2-week washout), one typically Brazilian and a modified one, differing concerning fiber and types of fatty acids contents. Clinical data were collected before and after each breakfast. A satiety scale was applied at fasting and 10, 30 and 120’ after breakfast consumption. Repeated measures ANOVA, Student t test or non-parametric correspondents were used; correlations were tested by Pearson or Spearman coefficients. Results Anthropometric variations after breakfasts were not significant. Only after the modified breakfast, reduction in blood pressure levels was observed. The satiety level did not show significant variation across each period or between the breakfasts. Non-significant correlation between satiety and glucose, insulin and HOMA-IR values after each intervention period was observed. Conclusion We conclude that different breakfast compositions do not alter satiety level, which is not correlated to glucose parameters in overweight individuals. Stronger modifications of daily meals might be necessary to differentiate satiety levels under distinct dietary patterns.

There are numerous particles, enzymes, and mechanisms in the lipid metabolism that are involved in the genesis of cardiovascular disease (CVD). Given its prevalence in populations and its impact on mortality, it is relevant to review the lipid metabolism as it may potentially provide subsidies to better prediction. This article reviews the importance of traditional cardiovascular risk factors and comments on the potential of novel lipid biomarkers involved in the physiopathology of CVD. The Framingham cohorts proved the role of traditional risk factors (physical inactivity, smoking, blood pressure, total cholesterol, LDL-C, HDL-C, plasma glucose) in the prediction of cardiovascular events. However, a significant number of individuals that suffer from a cardiovascular event has few or none of these factors. Such finding indicates the need for new biomarkers able to identify plaques that are more susceptible to rupture. Some of bloodstream biomarkers related to lipid metabolism are modified LDL particles, apolipoprotein AI (apo AI), apolipoprotein B, lipoprotein (a) [Lp (a)], cholesteryl ester transfer protein (CETP), subtypes of LDL and HDL particles, and lipoprotein-associated phospholipase A2 (Lp-PLA2). These factors participate in the atherosclerotic process, and are abnormal in individuals at high risk, or in those who suffered from a cardiovascular event. Lp (a) determination is already employed in clinical practice and should be included as a reference parameter for CVD monitoring. Furthermore, there are expectations for wider use of apo B, non-HDL cholesterol and total cholesterol / HDL-C determination to improve cardiovascular risk assessment.

A microbiota intestinal, adquirida no período pós-natal, é composta por grande diversidade de bactérias que desempenham diferentes funções no hospedeiro humano, entre elas a absorção de nutrientes, proteção contra patógenos e modulação do sistema imune. O conteúdo bacteriano intestinal ainda não é totalmente conhecido, mas sabe-se que é influenciado por fatores internos e principalmente externos que modulam sua composição e função. Estudos indicam que a microbiota intestinal difere em indivíduos magros e obesos e ainda naqueles que mantêm hábitos alimentares diferentes. Há evidências de que as relações entre dieta, inflamação, resistência à insulina e risco cardiometabólico são em parte mediadas pela composição de bactérias intestinais. Conhecimentos sobre a microbiota poderão reverter em diferentes estratégias para manipular as populações bacterianas e promover saúde. Esta revisão aborda a relevância do conhecimento sobre o papel de fatores ou padrões alimentares na composição da microbiota, assim como mecanismos fisiopatológicos de doenças metabólicas crônicas e as potencialidades de prebióticos e probióticos sobre o perfil de risco cardiometabólico.

The gut microbiota obtained after birth is composed of a large range of bacteria that play different roles in the human host, such as nutrient uptake, protection against pathogens and immune modulation. The intestinal bacterial content is not completely known, but it is influenced by internal, and mainly by external factors, which modulate its composition and function. Studies indicate that the gut microbiota differs in lean and obese individuals, and in individuals with different food habits. There is evidence that the relationship between diet, inflammation, insulin resistance, and cardiometabolic risk are, in part, mediated by the composition of intestinal bacteria. Knowledge about the gut microbiota may result in different strategies to manipulate bacterial populations and promote health. This review discusses the relevance of understanding the role of dietary factors or patterns in the composition of the microbiota, as well as pathophysiological mechanisms of chronic metabolic diseases, and the potential of prebiotics and probiotics on the cardiometabolic risk profile.

OBJETIVO: avaliar a relação entre a doença arterial obstrutiva periférica e níveis elevados de proteína C-reativa em população nipo-brasileira de alto risco cardiovascular.MÉTODOS: estudo transversal derivado de estudo de base populacional sobre a prevalência de diabetes e doenças associadas em população nipo-brasileira. Mil trezentos e trinta indivíduos com idade >30 foram submetidos a exame clínico e laboratorial, incluindo a dosagem da proteína C-reativa ultrassensível. O diagnóstico da doença arterial obstrutiva periférica foi realizado através do cálculo do índice tornozelo-braço. Foram considerados portadores de doença arterial obstrutiva periférica os pacientes que apresentaram índice tornozelo-braço <0,9. Após aplicação dos critérios de exclusão, 1038 indivíduos completaram o estudo.RESULTADOS: a média de idade da população foi 56,8 anos, 46% pertencentes ao sexo masculino. A prevalência da doença arterial obstrutiva periférica foi 21%, sem diferença entre os sexos. A análise dos dados não mostrou associação entre doença arterial obstrutiva periférica e proteína C-reativa ultrassensível. Os pacientes com índice tornozelo-braço <0,70 apresentaram valores mais elevados de proteína C-reativa ultrassensível e o pior perfil cardiometabólico. Encontramos associação positiva e independente da doença arterial obstrutiva periférica com hipertensão arterial e tabagismo. .CONCLUSÃO: a associação encontrada entre valores baixos de índice tornozelo-braço e níveis elevados de proteína C-reativa ultrassensível pode sugerir uma relação de gravidade auxiliando mapeamento dos pacientes de maior risco.

OBJECTIVE: To evaluate the relationship between peripheral arterial disease and elevated levels of C-reactive protein in the Japanese-Brazilian population of high cardiovascular risk.METHODS: We conducted a cross-sectional study derived from a population-based study on the prevalence of diabetes and associated diseases in the Japanese-Brazilian population. One thousand, three hundred and thirty individuals aged e" 30 underwent clinical and laboratory examination, including measurement of ultrasensitive C-reactive protein. The diagnosis of peripheral arterial disease was performed by calculating the ankle-brachial index. We considered with peripheral arterial disease patients who had ankle-brachial index d" 0.9. After applying the exclusion criteria, 1,038 subjects completed the study.RESULTS: The mean age of the population was 56.8 years; 46% were male. The prevalence of peripheral arterial disease was 21%, with no difference between genders. Data analysis showed no association between peripheral arterial disease and ultrasensitive C-reactive protein. Patients with ankle-brachial index d" 0.70 showed higher values of ultrasensitive C-reactive protein and worse cardiometabolic profile. We found a positive independent association of peripheral arterial disease with hypertension and smoking.CONCLUSION: The association between low levels of ankle-brachial index and elevated levels of ultrasensitive C-reactive protein may suggest a relationship of gravity, aiding in the mapping of high-risk patients.

Fundamento: As patologias cardiovasculares são a maior causa de morbimortalidade nos países desenvolvidos e emergentes. Sua principal etiologia, a aterosclerose, é doença disseminada acometendo os territórios coronariano, cerebral e periférico. A doença arterial obstrutiva periférica (DAOP), além de suas consequências per se, sinaliza o acometimento do território coronariano. Portanto, seu melhor conhecimento permite tratamento adequado, retardando complicações locais e à distância, diminuindo o custo para o sistema de saúde. Objetivo: Este estudo estima a porcentagem de DAOP em nipo-brasileiros de Bauru (SP), reconhecidos pela alta prevalência de distúrbios metabólicos, como hipertensão arterial (43%), diabetes melito (33%) e hipercolesterolemia (60 %), e analisa a associação com biomarcadores de risco. Métodos: Este estudo transversal populacional avaliou 1.330 nipo-brasileiros de ambos os sexos com idade ≥ 30 anos que foram submetidos a exame físico completo, medidas antropométricas, exames laboratoriais e índice tornozelo-braço (ITB). Participantes com ITB ≤ 0,90 foram diagnosticados como portadores de DAOP. Após aplicação dos critérios de exclusão, 1.038 indivíduos integraram a análise. Empregou-se regressão de Poisson para análise das associações com DAOP. Resultados: A idade média foi 56,8 anos e a porcentagem de DAOP foi 21,1%, igual entre os sexos. DAOP associou-se com tabagismo (RP 2,16 [1,33-3,48]) e hipertensão arterial (RP 1,56 [1,12-2,22]). Conclusão: A porcentagem de DAOP nos nipo-brasileiros foi semelhante à de outras populações de perfil cardiometabólico desfavorável (US PARTNERS e POPADAD). A associação independente de DAOP com tabagismo e hipertensão, mas não com outros clássicos fatores de risco, pode depender das frequências muito elevadas dos distúrbios metabólicos nessa população.

Background: Cardiovascular diseases are the major cause of morbidity and mortality in developed and emerging countries. Their main etiology, atherosclerosis, is a disseminated disease that affects the coronary, cerebral and peripheral territories. The peripheral arterial disease (PAD), as well as its consequences, indicates the involvement of the coronary territory. Therefore, its better understanding enables proper treatment, delaying local and long-term complications, reducing the cost to the health system. Objective: This study estimates the percentage of PAD in Japanese-Brazilians from Bauru (SP), recognized by the high prevalence of metabolic disorders such as hypertension (43%), diabetes mellitus (33%) and hypercholesterolemia (60%), and examines the association with risk biomarkers. Methods: This cross-sectional population study evaluated 1,330 Japanese-Brazilians of both genders aged ≥ 30 who underwent a complete physical examination, anthropometric measurements, laboratory tests and ankle-brachial index (ABI). Participants with ABI ≤ 0.90 were diagnosed as having PAD. After applying the exclusion criteria, 1,038 individuals were part of the analysis. We used Poisson regression to analyze associations with PAD. Results: The mean age was 56.8 years and the percentage of PAD was 21.1%, equal among the genders. PAD was associated with smoking (PR 2.16 [1.33 to 3.48]) and hypertension (PR 1.56 [1.12-2.22]). Conclusion: The percentage of PAD in Japanese-Brazilians was similar to other populations of adverse cardiometabolic profile (US PARTNERS and POPADAD). The independent association of PAD with smoking and hypertension, but not with other classical risk factors, may depend on the very high frequencies of metabolic disorders in this population.

OBJETIVO: Este estudo comparou parâmetros antropométricos e de resistência à insulina de indivíduos sem e com síndrome metabólica (SM), subestratificados pela presença de anormalidades glicêmicas. SUJEITOS E MÉTODOS: Foram incluídos 454 indivíduos (66% mulheres, 54% brancos), sendo 155 alocados para o grupo 1 (sem SM, sem anormalidade glicêmica), 32 para o grupo 2 (sem SM, com anormalidade glicêmica), 104 no grupo 3 (com SM, sem anormalidade glicêmica) e 163 no grupo 4 (com SM e anormalidade glicêmica). Os grupos foram comparados por ANOVA. RESULTADOS: Os grupos com SM (3 e 4) apresentaram os piores perfis antropométrico e lipídico; no grupo 2, apesar de glicemias significantemente mais elevadas, as médias das variáveis antropométricas e lipídicas não diferiram do grupo 1. Os maiores valores médios de HOMA-IR foram encontrados nos grupos com SM, enquanto o grupo 2 apresentou o menor HOMA-β. A trigliceridemia foi a variável metabólica com coeficientes de correlação mais elevados com a antropometria. Porém, as correlações mais fortes foram da circunferência da cintura (r = 0,503) e da razão cintura-altura (r = 0,513) com o HOMA-IR (p < 0,01). CONCLUSÃO: Nossos achados revelam que, em amostra da população brasileira, qualquer das medidas antropométricas identifica indivíduos com SM, mas não parece capaz de diferenciar aqueles com distúrbio glicêmico. Reforçamos a relação mais forte das medidas de adiposidade central com resistência à insulina, sugerindo utilidade da razão cintura-altura. É possível que componente autoimune contribua para o comprometimento do metabolismo glicídico dos indivíduos do grupo 2.

OBJECTIVE: This study compared anthropometric measurements and insulin resistance indexes of individuals with or without metabolic syndrome (MS), stratified by the presence of glycemic abnormalities. SUBJECTS AND METHODS: 454 individuals (66% women, 54% Caucasians) were included, being 155 allocated to group 1 (without MS, without glycemic abnormality), 32 to group 2 (without MS, with glycemic abnormality), 104 to group 3 (with MS, without glycemic abnormality), and 163 to group 4 (with MS, with glycemic abnormality). Groups were compared by ANOVA. RESULTS: Those with MS (3 e 4) showed the worst anthropometric and lipid profiles; in group 2, despite higher plasma glucose levels, the mean values of anthropometric variables and lipids did not differ from group 1. The highest mean values of HOMA-IR were found in the groups with MS, while group 2 showed the lowest HOMA-β. Triglyceride was the metabolic variable with the highest correlation coefficients with anthropometry. However, the strongest correlations were those of waist circumference (r = 0.503) and waist-to-height ratio (r = 0.513) with HOMA-IR (p < 0.01). CONCLUSION: Our findings indicate that, in a sample of the Brazilian population, any anthropometric measure identifies individuals with MS, but such measurements seem to be unable to differentiate those with glycemic disturbance. We reinforce the strongest relationship of measures of central adiposity with insulin resistance, suggesting utility for the waist-to-height. An autoimmune component may be contributing to the deterioration of glucose metabolism of individuals from group 2.

Estudos recentes mostram que restrições na ingestão de sódio podem aumentar a resistência à insulina (RI) e induzir alterações nas lipoproteínas séricas e em marcadores de inflamação semelhantes às encontradas na síndrome metabólica (SM). Realizou-se uma revisão sistemática da literatura sobre os efeitos da restrição do consumo de sódio sobre a SM ou a RI. Nove artigos foram incluídos na revisão. A restrição no consumo de sódio associou-se ao aumento da RI em dois artigos e a diminuição em três outros. Em sete dos nove artigos, a restrição na ingestão de sal determinou redução da pressão arterial e em dois artigos ocorreram efeitos adversos em marcadores da SM. A maioria dos estudos mostrou efeitos benéficos da restrição moderada de sódio da dieta associados ou não a outras modificações nutricionais ou ao aumento da atividade física. Novos estudos são necessários para avaliar os efeitos de reduções moderadas no consumo de sódio sobre a SM e a RI.

Recent studies have shown that sodium intake restrictions may increase insulin resistance (IR) and induce changes on serum lipoproteins and on inflammation markers that are similar to those found in metabolic syndrome (MS). We performed a systematic review of literature regarding the effects of restricting sodium intake on MS or on IR. Nine articles were included in the review. Restriction of sodium consumption was associated with increase insulin resistance in two articles and with decrease in three others. In seven of nine articles, salt intake restriction determined blood pressure reduction, and in two articles adverse effects on markers of MS were found. Most studies showed beneficial effects of moderate sodium intake restriction, associated or not to others nutritional modifications or increased physical activity. Further studies are needed to evaluate the effects of moderate sodium consumption reductions on MS and IR.

OBJETIVO: Casamento interétnico entre brasileiros nikkeis e não nikkeis pode favorecer a ocidentalização da dieta. Compararam-se consumo alimentar, dados clínico-laboratoriais e frequências de doenças metabólicas em população nipo-brasileira, com casamento intraétnico ou interétnico. MÉTODOS: Empregaram-se teste t, Mann-Whitney, qui-quadrado e coeficiente de Pearson. RESULTADOS: Em 1009 nipo-brasileiros havia 18,9% de casamentos interétnicos, mais frequentes entre homens nikkeis. Estes apresentaram maiores médias de IMC, cintura, pressão arterial, glicemia e triglicérides que mulheres. As frequências de obesidade, hipertrigliceridemia e síndrome metabólica foram 47,7%, 68,1% e 45,2%, sendo maiores nos casamentos interétnicos comparados aos intraétnicos. Comparando-se indivíduos com casamento interétnico, hipertrigliceridemia foi mais frequente nos homens e HDL-c baixo nas mulheres. O consumo de calorias, gorduras e dos grupos de álcool, doces e óleos foram maiores nos casamentos interétnicos. Indivíduos casados intraetnicamente consumiam mais carboidratos, proteínas, fibras, vitaminas, minerais, hortaliças, frutas/sucos, cereais e missoshiru. Comparando-se indivíduos com casamento interétnico, homens nikkeis apresentavam padrão mais ocidental que mulheres nikkeis. CONCLUSÃO: Casamento interétnico associa-se a hábitos alimentares menos saudáveis e pior perfil de risco cardiometabólico.

OBJECTIVE: Interethnic marriage between nikkey Brazilians and non-nikkey Brazilians may favor the westernization of diet. Dietary consumption, clinical data and frequencies of metabolic diseases were compared in a Japanese-Brazilian population, with intraethnic or interethnic marriage. METHODS: T test, Mann-Whitney, chi-square and Person coefficient were used. RESULTS: Among 1009 Japanese-Brazilians there were 18.9% of interethnic marriage, being more frequent among nikkey men. These showed higher means of BMI, waist, blood pressure, glycemia and triglyceridemia than women. Overall frequencies of obesity, hypertrigliceridemia and metabolic syndrome were 47.7%, 68.1% and 45.2%, being higher in interethnic than intraethnic marriage. Comparing individuals with interethnic marriages, hypertriglyceridemia was more common among men while low-HDL among women. Energy, fat, groups of alcohol, sweets and oils were higher in interethnic marriage. Individuals with intraethnic marriage consumed more carbohydrate, proteins, fibers, vitamins, minerals, vegetables, fruits/juice, cereals and missoshiru. Comparing individuals with interethnic marriages, nikkey men showed a more westernized dietary pattern than nikkey women. CONCLUSION: Interethnic marriage was associated with less healthy food habits and worse cardiometabolic profile.

No processo celular de obtenção de energia, são gerados compostos chamados espécies reativas de oxigênio (ERO) que, em excesso, podem causar danos celulares. Estresse oxidativo resulta do desequilíbrio no estado de óxido-redução a favor da oxidação. Dos mecanismos de defesa antioxidante, participam enzimas endógenas e algumas vitaminas e minerais. A vitamina E encontra-se no plasma e na partícula de LDL, protegendo lipídeos da oxidação. Estudos observacionais relataram associação inversa entre ingestão de vitamina E e risco cardiometabólico (RCM). Entretanto, ensaios clínicos não comprovaram a eficácia de sua suplementação nos desfechos cardiometabólicos. A vitamina C participa do sistema de regeneração da vitamina E, mantendo o potencial antioxidante plasmático. Dados sobre os benefícios de sua suplementação na redução do risco cardiometabólico são inconclusivos. A atividade antioxidante dos carotenoides é responsável, em parte, por seu papel protetor contra doenças cardiovasculares e cânceres. A suplementação desse nutriente também não trouxe resultados consistentes no que se refere à redução do RCM. A participação do zinco e do selênio na defesa antioxidante vem sendo estudada mais recentemente, mas a sua suplementação em indivíduos com níveis séricos normais e ingestão adequada na dieta desses minerais não parece ser necessária. De um modo geral, há muita controvérsia sobre o papel desses micronutrientes no RCM. Estudos epidemiológicos sugerem que o consumo de substâncias antioxidantes provenientes da dieta ou dietas ricas em frutas e hortaliças diminui o RCM. Mais estudos são necessários antes de se recomendar o uso de antioxidantes isolados na forma de suplementos para tal finalidade.

Oxygen reactive species (ROS) are generated during cellular processes. In excess, they may cause damages to the cell. Oxidative stress is an imbalance in the redox state that favors oxidation. Endogenous enzymes and some vitamins and minerals participate in the plasma antioxidant defense. Vitamin E is found in the plasma and in the LDL particle, avoiding lipid peroxidation. Observational studies reported an inverse association between vitamin E consumption and cardiometabolic (CM) risk. However, clinical trials were not able to prove the efficacy of its supplementation on CM endpoints. Vitamin C participates in the vitamin E regeneration system, keeping the plasma's antioxidant potential. Data about beneficial effects of its supplementation in CM risk reduction are inconclusive. The antioxidant activity of carotenoids is partially responsible for its protective role against cardiovascular diseases and cancer. Supplementation of this nutrient did not provide consistent findings in terms of CM risk reduction. Recently, zinc and selenium's participation in the antioxidant defense has been studied, yet its supplementation in individuals with normal levels and adequate ingestion of these nutrients does not seem necessary. In summary, the role of these micronutrients for CM risk is still very controversial. Epidemiological studies suggest that diets rich in antioxidants, or simply in fruit and vegetables intake, can reduce CM risk. Further studies are needed before recommending antioxidant supplements for this purpose.

Avaliou-se o impacto de intervenção no estilo de vida no perfil de risco cardiometabólico de mulheres participantes do Estudo de Diabetes e Doenças Associadas na População Nipo-Brasileira de Bauru. O delineamento foi experimental não-controlado, incluindo avaliação clínico-laboratorial basal e um ano após a intervenção. Examinaram-se 401 nipo-brasileiras (60,8 ± 11,7 anos) sendo 365 classificáveis quanto à presença de síndrome metabólica, estimada em 50,6%. Portadoras de síndrome metabólica eram mais velhas que aquelas sem a síndrome (63,0 ± 10,0 vs. 56,7 ± 11,6 anos; p < 0,01). A intervenção associou-se à melhora nas variáveis avaliadas exceto na proteína C reativa. O índice de massa corporal e a cintura caíram, sendo a redução da adiposidade mais marcante na região abdominal (87,0 ± 9,7 para 84,5 ± 11,2cm; p < 0,001). As diferenças induzidas pela intervenção nos níveis de colesterol total, LDL e glicose pós-sobrecarga foram significantes; mulheres que reduziram > 5% do peso apresentaram melhor perfil que as que mantiveram ou ganharam. Programa de intervenção no estilo de vida em nipo-brasileiras de alto risco cardiometabólico, melhorou o perfil antropométrico e bioquímico, porém, se desconhece se serão duradouros, reduzindo eventos cardiovasculares em longo prazo.

We evaluated the impact of a lifestyle intervention on the cardiometabolic risk profile of women participating in the Study on Diabetes and Associated Diseases in the Japanese-Brazilian Population in Bauru. This was a non-controlled experimental study including clinical and laboratory values at baseline and after a 1-year intervention period. 401 Japanese-Brazilian women were examined (age 60.8±11.7 years), and 365 classified for metabolic syndrome (prevalence = 50.6%). Subjects with metabolic syndrome were older than those without (63.0±10.0 vs. 56.7±11.6 years, p < 0.01). After intervention, improvements in variables were found, except for C-reactive protein. Body mass index and waist circumference decreased, but adiposity reduction was more pronounced in the abdominal region (87.0±9.7 to 84.5±11.2cm, p < 0.001). Intervention-induced differences in total cholesterol, LDL, and post-challenge glucose were significant; women who lost more than 5% body weight showed a better profile than those who did not. The lifestyle intervention in Japanese-Brazilian women at high cardiometabolic risk improved anthropometric and laboratory parameters, but it is not known whether such benefits will persist and result in long-term reduction in cardiovascular events.

Avaliou-se o impacto de intervenção no estilo de vida no perfil de risco cardiometabólico de mulheres participantes do Estudo de Diabetes e Doenças Associadas na População Nipo-Brasileira de Bauru. O delineamento foi experimental não-controlado, incluindo avaliação clínico-laboratorial basal e um ano após a intervenção. Examinaram-se 401 nipo-brasileiras (60,8 ± 11,7 anos) sendo 365 classificáveis quanto à presença de síndrome metabólica, estimada em 50,6%. Portadoras de síndrome metabólica eram mais velhas que aquelas sem a síndrome (63,0 ± 10,0 vs. 56,7 ± 11,6 anos; p < 0,01). A intervenção associou-se à melhora nas variáveis avaliadas exceto na proteína C reativa. O índice de massa corporal e a cintura caíram, sendo a redução da adiposidade mais marcante na região abdominal (87,0 ± 9,7 para 84,5 ± 11,2cm; p < 0,001). As diferenças induzidas pela intervenção nos níveis de colesterol total, LDL e glicose pós-sobrecarga foram significantes; mulheres que reduziram > 5% do peso apresentaram melhor perfil que as que mantiveram ou ganharam. Programa de intervenção no estilo de vida em nipo-brasileiras de alto risco cardiometabólico, melhorou o perfil antropométrico e bioquímico, porém, se desconhece se serão duradouros, reduzindo eventos cardiovasculares em longo prazo.

We evaluated the impact of a lifestyle intervention on the cardiometabolic risk profile of women participating in the Study on Diabetes and Associated Diseases in the Japanese-Brazilian Population in Bauru. This was a non-controlled experimental study including clinical and laboratory values at baseline and after a 1-year intervention period. 401 Japanese-Brazilian women were examined (age 60.8±11.7 years), and 365 classified for metabolic syndrome (prevalence = 50.6%). Subjects with metabolic syndrome were older than those without (63.0±10.0 vs. 56.7±11.6 years, p < 0.01). After intervention, improvements in variables were found, except for C-reactive protein. Body mass index and waist circumference decreased, but adiposity reduction was more pronounced in the abdominal region (87.0±9.7 to 84.5±11.2cm, p < 0.001). Intervention-induced differences in total cholesterol, LDL, and post-challenge glucose were significant; women who lost more than 5% body weight showed a better profile than those who did not. The lifestyle intervention in Japanese-Brazilian women at high cardiometabolic risk improved anthropometric and laboratory parameters, but it is not known whether such benefits will persist and result in long-term reduction in cardiovascular events.