RESUMEN Los modos de esquema (MEs) se discuten ampliamente en la teoría y práctica de la Terapia de Esquemas (TE). Sin embargo, aún existe una falta de estudios culturalmente sensibles que aborden las necesidades de grupos sociales minoritarios (GSM), incluidas las minorías sexuales y de género (MSG). Esto es un problema significativo que resulta en prácticas inconsistentes entre los profesionales al trabajar con esta población, que aún está subrepresentada en la literatura científica. Los objetivos de este artículo son (1) presentar estudios disponibles en la literatura sobre MEs en MSG y (2) sugerir posibles direcciones y reflexiones sobre el mapa de modos en MSG. Se realizó una revisión narrativa utilizando las bases de datos Scopus, Web of Science, PubMed, APA (PsycINFO), SciELO, Lilacs y Google Scholar, sin importar el año de publicación, con los descriptores: “schema mode$” AND “sexual and gender minorit*” e “schema mode” AND “sexual and gender minority”. Solo se recuperó un estudio, y se describe en este artículo. Se ilustra el mapa de modos en MSG, ampliando la comprensión del estudio encontrado en la literatura. Se fomenta la realización de estudios empíricos que involucren diferentes perspectivas de GSM dentro de la TE y que los terapeutas estén atentos a las variables socioculturales en el entorno clínico, incluidas las necesidades y vulnerabilidades de esta población.

RESUMO Os modos esquemáticos (MEs) são amplamente debatidos na teoria e prática da terapia do esquema (TE). Contudo, ainda são escassos os estudos culturalmente sensíveis às demandas de grupos sociais minoritários (GSM), os quais incluem minorias sexuais e de gênero (MSG). Esse é um problema significativo que reverbera em uma prática inconsistente de profissionais ao atender essa população, que ainda é invisibilizada nas produções científicas. São objetivos deste artigo (1) apresentar estudos disponíveis na literatura sobre MEs em MSG e (2) indicar possíveis encaminhamentos e reflexões acerca do mapa de modos em MSG. Foi realizada uma revisão narrativa a partir das bases Scopus, Web of Science, PubMed, APA (PsycINFO), SciELO, Lilacs e Google Acadêmico, independentemente do ano de publicação, a partir dos descritores: “schema mode$” AND “sexual and gender minorit*” e “schema mode” AND “sexual and gender minority”. Apenas um estudo foi recuperado, sendo este o descrito neste artigo. O mapa de modos em MSG é ilustrado, expandindo a compreensão do estudo encontrado na literatura. Incentiva-se a condução de estudos empíricos com diferentes GSM sob a perspectiva da TE e a atenção dos terapeutas quanto às variáveis socioculturais que permeiam o setting clínico, incluindo suas necessidades e vulnerabilidades.

ABSTRACT Schema modes (SMs) are widely discussed in the theory and practice of Schema Therapy (ST). However, there is still a lack of culturally sensitive studies addressing the needs of social minority groups (SMG), including sexual and gender minorities (SGM). This is a significant issue that results in inconsistent practices among professionals when working with this population, which is still underrepresented in scientific literature. The objectives of this article are (1) to present available studies in the literature on SMs in SGM and (2) to suggest possible directions and reflections regarding the mode map in SGM. A narrative review was conducted using the Scopus, Web of Science, PubMed, APA (PsycINFO), SciELO, Lilacs, and Google Scholar databases, regardless of the publication year, with the descriptors: “schema mode$” AND “sexual and gender minorit*” and “schema mode” AND “sexual and gender minority.” Only one study was retrieved, and it is described in this article. The mode map in SGM is illustrated, expanding the understanding of the study found in the literature. Encouragement is given for empirical studies involving different SMG perspectives within ST and for therapists to be attentive to sociocultural variables in the clinical setting, including the needs and vulnerabilities of this population.

Abstract Ring shape microstrip antenna designs supported via an altered ground plane profile are proposed for multi-band response with wider bandwidth in each band. The impedance bandwidth of a single ring patch supported via a slot cut ground plane on a substrate having a thickness of ~ 0.1λg, is 45.8% and the broadside gain is 5.6 dBi. By employing additional stack patches, dual and triple-band configurations are obtained. In the respective operative frequency bands, maximum 15% of bandwidth is achieved in the suggested antenna, with a maximum broadside gain of more than 5.5 dBi. Through the acquired antenna features, the proposed configuration fulfills the criteria of E-GSM900/Secondary Surveillance Radar/Aeronautical Radio Navigation Applications.

Abstract Objective: This meta-analysis of randomized controlled trials (RCTs) aimed to update evidence on the effectiveness and safety of laser therapy for treating genitourinary syndrome of menopause (GSM). Data sources: Manuscripts published until May 2023 were systematically searched in PubMed; Embase; Scopus; Web of Science; CENTRAL; CINAHL; and clinical trial databases (www.trialscentral.org, www.controlled-trials.com, and clinicaltrials.gov), with no language and year of publication restriction. Studies selection: RCTs with women diagnosed with GSM, and the intervention was vaginal laser therapy (CO2-laser or Er: YAG-laser) comparing with placebo (sham therapy), no treatment or vaginal estrogen therapy. Data collection: Two authors evaluated the publications for inclusion based on the title and abstract, followed by reviewing the relevant full-text articles. Disagreements during the review process were addressed by consensus, with the involvement of a third author. Data synthesis: Twelve RCTs, representing a total of 5147 participants, were included in this review. Vaginal health index (VHI) significantly improved in the carbon dioxide laser (CO2-laser) therapy group (MD=2.21; 95% CI=1.25 to 3.16), while dyspareunia (MD=−0.85; 95% CI=−1.59 to −0.10), dryness (MD=−0.62; 95% CI=−1.12 to −0.12) and burning (MD= −0.64; 95% CI=−1.28 to −0.01) decreased. No serious adverse effects were reported. Conclusion: CO2-laser increases VHI score and decreases dyspareunia, dryness and burning, especially when compared to sham-laser. However, the certainty of the evidence is low, thus preventing the recommendation of laser therapy for GSM management.

Abstract Objective This study aimed to translate and validate the Estro-Androgenic-Symptom Questionnaire in Women (EASQ-W) into Brazilian Portuguese language, as we hypothesized that this tool would be consistent for addressing the specific context of hormonal symptoms in menopause. Methods In a cross-sectional study, a total of 119 women with Genitourinary Syndrome of Menopause (GSM) and 119 climacteric women without GSM were included. The EASQ-W was translated, and its psychometric properties were rigorously examined. Participants completed questionnaires covering sociodemographic details, the EASQ-W, and the Menopause Rating Scale (MRS). A subgroup of 173 women was re-invited after 4 weeks for test-retest analysis of the EASQ-W. Additionally, the responsiveness of the questionnaire was evaluated in 30 women who underwent oral hormonal treatment. Results The internal consistency of the EASQ-W was found to be satisfactory in both GSM and control groups (Cronbach’s alpha ≥ 0.70). Notably, a floor effect was observed in both groups; however, a ceiling effect was only evident in the sexual domain of the GSM group. Construct validity was established by comparing the EASQ-W with the MRS, yielding statistically significant correlations (0.33831-0.64580, p < 0.001). The test-retest reliability over a 4-week period was demonstrated to be satisfactory in both the GSM and control groups (ICC 0.787-0.977). Furthermore, the EASQ-W exhibited appropriate responsiveness to oral hormonal treatment (p < 0.001). Conclusion This study successfully translated and validated the Estro-Androgenic-Symptom Questionnaire in Women (EASQ-W) into Brazilian Portuguese, with satisfactory internal consistency, test-retest reliability, and construct validity.

RESUMEN El objetivo fue determinar la energía metabolizable aparente (EMAn) y digestibilidad íleal aparente (CDI) de aminoácidos en la harina de calamar gigante (Dosidicus gigas) (HCG), como alternativa proteica en dietas para pollos de engorda. Experimento 1: en la HCG se determinó la EMAn y el CDI de sus aminoácidos. A 96 pollos se les proporcionó dieta con 8 y 16% de HCG durante 21 días de edad. Experimento 2: 72 pollos fueron alimentados con 16 y 20% de HCG en la dieta, durante 42 días. Variables productivas, rendimiento de canal, color de piel y sabor fueron evaluados. Resultados: EMAn fue 3376.15 kcal/kg y CDI de los aminoácidos mayor a 68%, excepto histidina (21%) y cisteína (47%). Ganancia de peso y peso final se redujeron con 16% HCG (P < 0.05) respecto al testigo a los 21 días de edad, sin embargo, a los 42 días no se detectaron diferencias (P > 0.05) entre tratamientos con 16 y 20%, tanto en las variables productivas como en rendimiento de la canal y peso de pollos (P > 0.05). El sabor de la carne no se vio afectado por HCG (P > 0.05). Se concluye que la HCG es una fuente alterna de proteína en dietas para pollos de engorda.

ABSTRACT The objective was to determine apparent metabolizable energy (AMEn) and apparent ileal digestibility (AID) of amino acids in giant squid (Dosidicus gigas) (GSM) meal, as a protein alternative in diets for broilers. Experiment 1: in GSM the AMEn and the AID of its amino acids were determined. Ninety-six chickens were fed a diet with 8 and 16% GSM for 21 days of age. Experiment 2: 72 chickens were fed with 16 and 20% GSM in the diet for 42 days. Productive parameters, carcass yield, skin color and flavor meat were evaluated. Results: AMEn was 3376.15 kcal/kg and AID of amino acids greater than 68%, except histidine (21%) and cysteine (47%). Weight gain and final weight were reduced with 16% GSM (P < 0.05) compared to the control at 21 days of age, however at 42 days no differences were detected (P > 0.05) between treatments with 16 and 20%, both in the productive parameters and in carcass yield and chicken weight (P > 0.05). The taste of the meat was not affected by GSM (P > 0.05). It is concluded that GSM is an alternate source of protein in diets for broilers.

Resumen Introducción. El calamar gigante (Dosidicus gigas) es una especie de gran abundancia y está considerado como un recurso potencial para satisfacer la demanda de proteína en Perú. La harina de calamar gigante representa una alternativa a las proteínas tradicionales, el cual puede ser usado en la fortificación de alimentos. Objetivo. Optimizar el proceso de extracción e identificación de proteínas solubles de la harina de calamar gigante (HCG). Materiales y métodos. Este estudio se realizó en la Universidad Agraria La Molina, Lima, Perú, entre 2018 y 2019. Para obtener el mayor rendimiento de proteína soluble (Ŷ) extraída, se aplicó el método de extracción alcalina utilizando NaOH seguido de una precipitación ácida a un pH de 4,5. Se utilizó metodología de respuesta de superficie para determinar los parámetros óptimos para la extracción de proteínas como temperatura, concentración de NaCl, tiempo y la relación HCG: solvente. Se realizó un estudio de electroforesis 1D y 2D para encontrar la distribución de pesos moleculares e identificar las principales proteínas del HCG. Resultados. Los valores de respuesta óptima fueron la concentración de NaCl 0 M, un tiempo de extracción de 35 min, la relación HCG: solvente de 1:31,72 y una temperatura de 71,9 °C. Los pesos moleculares de las proteínas detectadas estuvieron en el rango de 6,5 y 38,37 kDa, lo que correspondería a tropomiosinas, troponinas y residuos de cadenas ligeras de miosina. Conclusiones. Este estudio permitió optimizar los parámetros de extracción e identificar las proteínas solubles las cuales corresponden a la fracción sarcoplasmática de la harina de calamar gigante (HCG), lo cuales pueden ser utilizados en la industria de alimentos.

Abstract Introduction. The giant squid (Dosidicus gigas) is a species of great abundance and considered as potential resource to meet the demand for protein in Peru. Giant squid meal represents an alternative to traditional proteins which can be used in food fortification. Objective. To optimize the extraction process and identification of soluble protein from giant squid meal (GSM). Materials and methods. This study was conducted at the Universidad Nacional Agraria La Molina, Lima, Peru, between 2018 and 2019. To obtain the highest yield of soluble protein (Ŷ) extracted, an alkaline extraction method using NaOH followed by acid precipitation at pH 4.5 was applied. Surface response methodology was used to determine the optimal parameters for protein extraction such as temperature, concentration of NaCl, time, and the ratio GSM: solvent. A 1D and 2D electrophoresis study was carried out to find the distribution of molecular weights and to identify the main proteins of GSM. Results. Values for optimal response were the concentration of NaCl 0 M, an extraction time of 35 min, the ratio GSM: solvent of 1:31.72, and a temperature at 71.9 ºC. The molecular weights of the proteins detected were in the range of 6.5 and 38.37 kDa, which would correspond to tropomyosins, troponins, and myosin light chain residues. Conclusions. This study allowed to optimize the extraction parameters and to identify soluble proteins corresponding to the sarcoplasmic fraction of the giant squid meal (GSM), which could be used in the food industry.

Resumo Fatores relativos à placa aterosclerótica podem indicar instabilidade como ulcerações, hemorragias intraplaca, núcleo lipídico, capa fibrosa delgada ou irregular e inflamação. A mediana de escala de cinza (GSM, de greyscale median) da placa é um dos métodos mais difundidos de estudo da placa aterosclerótica; nesse sentido, é importante criar uma padronização da pós-processamento de forma compreensível. O pós-processamento foi realizado no software Photoshop 23.1.1. A padronização da imagem foi alcançada com o ajuste de curvas do histograma de escalas de cinza definindo o ponto mais escuro do lúmen vascular (sangue) para zero e a adventícia distal para 190. A posterização e o remapeamento de cores foram realizados. Um método que apresenta o atual estado da arte da técnica de forma acessível e ilustrativa pode contribuir para disseminação da análise de GSM. Neste artigo, esse processo é demonstrado passo a passo. ulcerações intraplaca lipídico inflamação GSM, GSM (GSM median sentido pósprocessamento pós processamento compreensível 2311 23 1 23.1.1 sangue (sangue 190 realizados artigo 231 2 23.1. 19 23.1 23.

Abstract Factors related to atherosclerotic plaques may indicate instability, such as ulcerations, intraplaque hemorrhages, lipid core, thin or irregular fibrous cap, and inflammation. The grayscale median (GSM) value is one of the most widespread methods of studying atherosclerotic plaques and it is therefore important to comprehensively standardize image post-processing. Post-processing was performed using Photoshop 23.1.1.202. Images were standardized by adjusting the grayscale histogram curves, setting the darkest point of the vascular lumen (blood) to zero and the distal adventitia to 190. Posterization and color mapping were performed. A methodology that presents the current state of the art in an accessible and illustrative way should contribute to the dissemination of GSM analysis. This article describes and illustrates the process step by step. instability ulcerations hemorrhages core cap inflammation (GSM postprocessing. postprocessing post processing. processing post-processing Postprocessing Post 2311202 23 1 202 23.1.1.202 curves blood (blood 190 analysis 231120 2 20 23.1.1.20 19 23112 23.1.1.2 2311 23.1.1. 231 23.1.1 23.1. 23.1 23.

ABSTRACT The GSM technology has been essential for extending mobile communication networks and continues to be widely deployed in areas with lower population density. At the same time, the development of IoT worldwide is extending to rural areas to improve agricultural processes and increase productivity. However, many rural communities need more connectivity due to the restrictive business models of telecommunications service operators. In this regard, GSM technology, and specifically technologies like OPENBTS, presents a viable alternative to providing network support. Successful cases like Rhizomática in Mexico and OpenBTS systems in Zambia have shown that it is possible to implement communication solutions that benefit communities. This article shows the potential of taking advantage of existing technological infrastructures to promote the development of IoT solutions employing systems such as OpenBTS, even with data transmission rate limitations. An evaluation of the performance of the OpenBTS system was included in a GPRS link, considering the level of throughput and latency, as well as latency analysis for QoS levels 0,1, and2 inMQTT. The results obtained a latency between 0.4s and0.75s using an FTP client-server scheme and between 0.05s and 0.15s using a client-server model with MQTT with different levels of quality of service. As for throughput, a maximum value of 15616.17 b/s was obtained in the downlink and 10853.58 b/s in the uplink.

RESUMEN La tecnología GSM ha sido esencial para extender las redes de comunicaciones móviles y sigue siendo ampliamente desplegada en zonas con menor densidad de población. Al mismo tiempo, el desarrollo del IoT a nivel mundial se extiende a las áreas rurales para mejorar los procesos agrícolas y aumentar la productividad. Sin embargo, muchas comunidades rurales carecen de conectividad debido a los modelos de negocio restrictivos de los operadores de servicios de telecomunicaciones. En este sentido, la tecnología GSM y específicamente tecnologías como OPENBTS se presentan como una alternativa viable para brindar soporte de red. Casos exitosos como Rhizomática en México y sistemas OpenBTS en Zambia han demostrado que es posible implementar soluciones de comunicación que beneficien a las comunidades. El presente artículo busca mostrar cómo es posible aprovechar esta infraestructura tecnológica existente para avanzar en el desarrollo de soluciones IoT empleando sistemas como OpenBTS, incluso con limitaciones en las tasas de transmisión de datos. Se incluye una evaluación del desempeño del sistema OpenBTS en un enlace GPRS, considerando el nivel de throughput y latencia, así como el análisis de latencia para los niveles QoS 0, 1 y 2 en MQTT. Dentro de los resultados se obtuvo una latencia entre 0,4s y 0,75s usando un esquema cliente servidor FTP y entre 0,05s y 0,15s usando un modelo cliente servidor con MQTT con los diferentes niveles de calidad de servicio. En cuanto al throughput se obtuvo un valor máximo de 15616,17 b/s en el downlink y 10853,58 b/s en el uplink.

Abstract: This study presents the design of a face mask detector that uses a camera, controlled by Raspberry PI with Python, which generates alerts when detecting people not properly wearing face masks during the COVID-19 pandemic. The system uses a security camera and GSM (Global System for Mobile Communication) wireless communication. The face mask detector equipped with artificial intelligence is implemented in the "La Joya" building at the Salesian Polytechnic University (Ecuador). The learning model is developed in stages. The results show that at stage 20, the accuracy and the test accuracy of the model reaches one. Similarly, data loss achieves zero at stage 20. It is concluded that the face mask detection system successfully monitors a specific area, improving the safety of students attending classes during the COVID-19 pandemic.

Resumen: En este estudio se presenta el diseño de un detector de mascarilla por medio de una cámara controlada por un Raspberry PI con Python que genera alertas en caso de detectar a personas que no usen correctamente la mascarilla durante la pandemia de COVID-19. Se utiliza una cámara de seguridad y comunicación inalámbrica a través de GSM (Global System for Mobile Communication). El detector con inteligencia artificial se implementa en el edificio “La Joya” de la Universidad Politécnica Salesiana (Ecuador). El aprendizaje del modelo se realiza por épocas. Los resultados muestran que en la época 20, la precisión y prueba de exactitud del modelo llegan a 1. De igual forma, la pérdida (Loss) de datos llega en la época 20 a tener una pérdida de datos de 0. Se concluye que el sistema de detección de mascarilla permite monitorear un área determinada, proporcionando un mejor cuidado de los estudiantes durante la pandemia de COVID-19.

Resumen Introducción: la enfermedad relacionada con IgG4 (ER-IgG4) es una afección inmunomediada, asociada con lesiones fibroinflamatorias que pueden ocurrir en casi cualquier órgano. Ante su sospecha clínica es fundamental realizar el examen histopatológico para excluir malignidad y otras enfermedades. El objetivo principal de este estudio fue describir los hallazgos histológicos de la biopsia de glándulas salivales labiales (GSL) en pacientes con diagnóstico de ER-IgG4 y, posteriormente, comparar estos hallazgos con la histología e inmunohistoquímica de la glándula salival mayor (GSM). Materiales y métodos: estudio retrospectivo, observacional y descriptivo sobre una cohorte de 40 pacientes con diagnóstico de ER-IgG4. Se incluyeron 26 pacientes con diagnóstico de ER-IgG4 que presentaron biopsias de GSL. Resultados: el 73% de la muestra tuvo un infiltrado linfoplasmocitario y el 11%, fibrosis con patrón no estoriforme. En ningún caso se halló arteritis obliterativa ni ninguna forma de flebitis. Al realizar la comparación con los hallazgos de las biopsias de GSM, no hubo significancia estadística. El 65% de los pacientes manifestó compromiso extraglandular y fueron los sistemas pancreato-hepato-biliar y las adenopatías los más afectados. Conclusiones: la biopsia incisional de glándula submandibular sería más útil y apropiada que la biopsia de GSL para un diagnóstico definitivo de ER-IgG4.

Abstract Introduction: IgG4-related disease (IgG4-RD) is an immune-mediated condition associated with fibroinflammatory lesions that can occur in almost any anatomical site. Histopathological examination is essential when suspected to diagnose it to exclude malignancy and other diseases. The objective of this study was to describe the histological findings of the minor salivary gland biopsy (GSL) in patients diagnosed with IgG4-RD, and subsequently to correlate these findings with the histology and immunohistochemistry of the major salivary gland (GSM). Materials and methods: retrospective, observational and descriptive study on a cohort of 40 patients diagnosed with RD-IgG4. Twenty-six patients diagnosed with IgG4-RD who presented SLG biopsies were included. Results: the 73% of the samples presented a lymphoplasmacytic infiltrate and 11% of them fibrosis with a non-storiform pattern. In no case was obliterative arteritis or any form of phlebitis found. When comparing the findings of the GSM biopsies, there was no statistical significance. Sixty-five percent of the patients presented extraglandular involvement; the pancreato-hepato-biliary system and the adenopathies were the most affected. Conclusions: incisional biopsy of the submandibular gland would be more useful and appropriate than LSG for a definitive diagnosis of IgG4-RD.

Abstract: Currently, conventional agriculture has been modified by new quality and quantity requirements and also by changes in climatic factors. In this context, it is necessary to implement emerging technologies that help to optimize natural and economic resources. One of the technological alternatives for the agricultural sector is the implementation of automated greenhouses using the Internet of things concept. One of the difficulties in implementing automated greenhouses is the technical difficulty and cost associated with building these new approaches. This work presents an internet of things architecture to monitor the variables involved within a greenhouse, using wireless connection and internet communication to publish the collected data. The system evaluation was conducted using a mesh covered greenhouse and demonstrated that it is possible to develop low-cost architectures that can connect to the cloud via WiFi or GSM / GPRS technology to upload data to a web server. This information is the input for new approaches that enable the automatic management of greenhouses.

Abstract Objectives: In this pilot, prospective, randomized, double-blind study, the authors compared the efficacy of oxytocin with promestriene in improving vaginal atrophy of Genitourinary Syndrome of Menopause (GSM). Methods: A total of 51 postmenopausal women with symptoms of GSM were evaluated. They were randomized into two groups: oxytocin (25 patients) and promestriene (26 patients) and were evaluated before and after 90 days of treatment; the evaluation was based on the domains of the Female Sexual Function Index (FSFI) (lubrication, satisfaction, and pain during sexual intercourse), clinical visual examination, and vaginal wall thickness. Results: After the use of the medications, both groups showed significant improvement in the three evaluated FSFI domains (p < 0.05) and there was no significant difference between the groups (p > 0.05). On clinical examination, the medications improved all the evaluated parameters but without statistical significance (p > 0.05). The evaluation of the thickness of the vaginal epithelium showed that both treatments led to increase in the vaginal epithelium (p < 0.05); however, the efficacy of promestriene was higher than that of oxytocin (p < 0.05). Conclusions: Both medications were effective, however, studies with larger samples and longer follow-ups are needed to confirm the clinical applicability.

SUMMARY: Considering that the submandibular gland (SMG) of postnatal mice performs active cell proliferation, apoptosis and differentiation which are regulated by proto-oncogene products in cancerous cells, the expression and localization of a proto-oncogene product HER (human epidermal growth factor receptor)-2 was examined in SMG of postnatal mice. In Western blot analysis, the expression for HER-2 was high until pre-puberty, and it decreased from puberty to young adult stages with male SMG more dominant. In immunohistochemistry, the immunoreactivity was positive in acinar and ductal cells of newborn SMG with distinct localization at the intercellular apposition sites. The immunoreactivity in acinar cells progressively decreased to negligible levels by pre-pubertal stage, while it remained positive in most ductal cells throughout the postnatal time-course. The immunoreactivity in cells of terminal tubules and intercalated ducts, both of which have a high potential to produce cells, were seen at levels similar to those of more proximal ducts, while the immunoreactivity in ductal basal cells was significantly high, but the granular convoluted tubule cells were seen at negligible levels in male and at faint levels in female. In immuno-electron microscopy of excretory ducts, the immunoreactivity was dominantly localized on the basal infolding membranes as well as vesicles and vacuoles of various sizes, but rarely in Golgi apparatus and mitochondria. The immunoreactivity without association to any membranous structures were also seen, though not numerous. The relation of expression levels of HER-2 in various portions of normal SMG to those in their cancerous ones is briefly discussed.

RESUMEN: Considerando que la glándula submandibular (GSM) de ratones postnatales realiza la proliferación celular activa, apoptosis y diferenciación que están reguladas por productos protooncogénicos en células cancerosas, la expresión y localización de un producto protooncogénico HER (receptor del factor de crecimiento epidérmico humano) - 2 se examinó en GSM de estos ratones. En el análisis de Western blot, la expresión de HER-2 fue alta hasta la prepubertad, y disminuyó desde la pubertad hasta las etapas de adultos jóvenes con GSM macho más dominante. En inmunohistoquímica, la inmunorreactividad fue positiva en las células acinares y ductales de GSM de recién nacido con una localización distinta en los sitios de aposición intercelular. La inmunorreactividad en las células acinares disminuyó progresivamente a niveles insignificantes en la etapa prepuberal, mientras que permaneció positiva en la mayoría de las células ductales durante el transcurso del tiempo posnatal. La inmunorreactividad en las células de los túbulos terminales y los conductos intercalados, los cuales tienen un alto potencial para producir células, se obser- vó a niveles similares a los de los conductos más proximales, mientras que la inmunorreactividad en las células basales ductales fue significativamente alta, pero en el túbulo contorneado granular las células se observaron en niveles insignificantes en los machos y en niveles débiles en las hembras. En la microscopía inmunoelectrónica de los conductos excretores, la inmunorreactividad se localizó de manera predominante en las membranas de pliegues basales, así como en vesículas y vacuolas de varios tamaños, pero raramente en el aparato de Golgi y en las mitocondrias. También se observó la inmunorreactividad sin asociación a ninguna estructura membranosa, aunque no numerosa. Se discute brevemente la relación de los niveles de expresión de HER-2 en varias porciones de GSM normal con aquellos en sus cancerosos.

Abstract A good wireless network design depends on technical and financial viability and a number of other criteria that must be met. Following the emergence of new technologies and services, such as 5G transmission and the reuse of frequencies, new work is being carried out to ensure a better design for a particular area. This study examines a discrete radio propagation model which employs the K nearest neighbors classifier. The model takes into account the different characteristics of the environment. This article presents a case study for the optimum positioning of base stations in Federal University of Pará (Belém – Brazil), representing a typical Amazon environment. The mentioned scenario is heterogeneous, presenting edifications and considerable forest area. Measurement campaigns were conducted in three different frequencies for the design features of the model: 521 MHz (Brazilian digital TV system), 2100 MHz (Enhanced Data Rates for GSM Evolution), and 2600 MHz (Long Term Evolution). A study of the fading phenomenon in these frequencies was carried out to generalize the frequencies of application for the propagation loss model. When this model was ready, tests (computing simulations) were conducted in two scenarios to optimize the positioning of the radio base stations being studied.

RESUMEN El calamar gigante Dosidicus gigas presenta un potencial para elaborar productos para consumo humano y alimentos balanceados por su alto contenido de proteína. El objetivo de este trabajo fue incluir 10 y 20 % de harina de calamar gigante (HCG) como fuente de proteína en dietas para gallinas ponedoras. Ciento treinta y cinco gallinas Bovans White se distribuyeron en testigo (T), 10 % (TI) y 20 % (T2) en ensayo de 6 semanas. Se midieron variables productivas, calidad física del huevo, proteína cruda, perfil de aminoácidos y evaluación sensorial (sabor). Proteína cruda en HCG (77.76 %), aminoácidos (g aa/100 de proteína): metionina+cisteína (3.76), lisina (10.16), isoleusina (4.26), leucina (6.56), fenilalanina (4.56) y triptófano (2.0). Variables productivas (P < 0.05) en postura (%); peso del huevo (g); conversión alimentaria (kg:kg) y masa de huevo (ave/día/g), y sin diferencia (P > 0.05) consumo (ave/día/g). Calidad física del huevo con diferencias (P < 0.05) en peso de huevo (g); altura de albúmina (mm) y unidades Haugh (UH). En huevo proteína cruda y aminoácidos diferencias (P < 0.05). Evaluación sensorial (P > 0.05), calificando los 3 tratamientos en 4 “gusta”. Se concluye que la harina de calamar gigante puede ser una alternativa como fuente de proteína para la alimentación de gallinas de postura no mayor al 10 %.

ABSTRACT The giant squid Dosidicus gigas has a great potential to elaborate human consumption products and balanced food due to its high protein content. The objective of this work was to inelude 10 and 20 % of giant squid meal (GSM) as a protein source in diets for laying hens. One hundred thirty-five Bovans White hens were distributed as follows: control (T), 10 % (T1), and 20 % (T2), in a 6-week trial. The Productive variables measured were the physical quality of the egg, crude protein, amino acid profile, and sensory evaluation (taste), Raw GSM protein (77.76 %), amino acids (g aa/100 protein): methionine + cysteine (3.76), lysine (10.16), isoleucine (4.26), leucine (6.56), phenylalanine (4.56) and tryptophan (2.0). The Productive variables measured were (P < 0.05) in posture (%); egg weight (g); food conversion (kg: kg) and egg mass (bird/day/g), and without difference (P > 0.05) consumption (bird/day/g); physical quality of the egg with differences (P < 0.05) in egg weight (g), albumin height (mm) and Haugh units (UH). In egg raw protein and amino acid differences (P < 0.05), Sensory evaluation (P > 0.05), rating the 3 treatments in 4 “likes”. According to the results, it is concluded that giant squid flour not exceeding 10 % can be an alternative as a source of protein for feeding posture hens.