Abstract Purpose To analyze the plasma lipid spectrum between healthy control and patients with pancreatic cancer and to select differentially expressed tumor markers for early diagnosis. Methods In total, 20 patents were divided into case group and healthy control group according to surgical pathology. Of almost 1206 plasma lipid molecules harvested from 20 patients were measured by HILIC using the normal phase LC/MS. Heat map presented the relative levels of metabolites and lipids in the healthy control group and patients with pancreatic cancer. The PCA model was constructed to find out the difference in lipid metabolites. The principal components were drawn in a score plot and any clustering tendency could be observed. PLS-DA were performed to distinguish the healthy control group and pancreatic cancer according to the identified lipid profiling datasets. The volcano plot was used to visualize all variables with VIP>1 and presented the important variables with P<0.01 and |FC|>2. Results The upregulated lipid metabolites in patients with pancreatic cancer contained 9 lipids; however, the downregulated lipid metabolites contained 79 lipids. Conclusion There were lipid metabolomic differences in patients with pancreatic cancer, which could serve as potential tumor markers for pancreatic cancer.

Abstract: The runoff variation characteristics of Dongting Lake were analyzed by applying the methods of concentration degree, concentration period, Mann-Kendall trend test, and variation coefficient. The analysis showed that: 1) The runoff concentration period of Dongting Lake occurs mainly between June and July of each year, with the peak time in late June-early July, and the composite vector directions in concentration period range from 103.2° to 190.2°; 2) The runoff variation coefficient ranges from 0.194 to 0.761, which indicates the instability of runoff. Extreme ratios of inflow and outflow are over 0.6 with an obvious attenuation; 3) The alternating pattern between wet years and dry years showed that the water distribution of the four rivers is relatively equal, while Ouchikou from three bayous is more violent, accounting for 32.79% of wet years and 57.38% of dry years respectively. The drastic change of annual water allocation is adverse to rational utilization of water resources.

Resumen: Se analizaron las características de la variación de escurrimiento del lago Dongting mediante la aplicación de los métodos de grado de concentración, periodo de concentración, análisis de tendencias de Mann-Kendall y coeficiente de variación. El análisis mostró que 1) el periodo de concentración de escurrimiento del lago Dongting ocurre principalmente entre junio y julio de cada año, presentándose el tiempo máximo entre finales de junio y principios de julio y las direcciones de los vectores compuestos en el periodo de concentración van de 103.2° a 190.2°; 2) el coeficiente de variación del escurrimiento oscila entre 0.194 y 0.761, lo cual indica la inestabilidad del escurrimiento. Las proporciones extremas del flujo de entrada y el flujo de salida son superiores a 0.6, con una obvia atenuación; 3) El patrón alternante entre los años húmedos y los años secos mostró que la distribución de agua de los cuatro ríos es relativamente igual, mientras que en Ouchikou, de tres canales pantanosos, es más violento, representando el 32.79% de los años húmedos y el 57.38% de los años secos, respectivamente. El drástico cambio de asignación anual de agua es adverso a la explotación racional de los recursos hídricos.