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Resumen Objetivo: Comparar la persistencia, tasa de retención y pauta de prescripción de infliximab original e infliximab CT-P13 en pacientes naive a biológicos con colitis ulcerosa. Método: Estudio ambispectivo de pacientes naive a biológicos en colitis ulcerosa que recibieron tratamiento en primera línea con Remicade® (infliximab) y Remsima® (infliximab CT-P13) de forma no simultánea durante un periodo de estudio de 10 años (2012-2021). Se tomaron datos de su edad, peso, persistencia, tasa de retención y si precisó de intensificación o desintensificación a lo largo del periodo de estudio. Se determinó el coste paciente/año real de Remicade® y Remsima® de forma individualizada en función de las administraciones durante el periodo del estudio. Resultados: Un total de 27 pacientes naive a biológicos fueron tratados con Remicade® y 53 con Remsima®. Ambos grupos de pacientes no presentaron diferencias en cuanto al peso y edad. La persistencia (mediana ± rango intercuartílico) con Remicade® fue de 42,49 ± 57,48 meses frente a 27,50 ± 58,50 meses para Remsima®, sin demostrar diferencias significati vas (p = 0,455). La tasa de retención a los 6, 12 y 24 meses fue del 81%, 63% y 33%, respectivamente, para el grupo de Remicade®, y del 71%, 47% y 37%, respectivamente, para el grupo de Remsima®. En el grupo de pacientes tratados con Remicade®, 9 pacientes fueron intensificados frente a 11 pacientes en el grupo de Remsima®. En cuanto a las desintensificaciones, 5 pacientes que recibieron tratamiento con Remicade® fueron desintensificados frente a 7 pacientes en tratamiento con Remsima®. El ahorro obtenido con el uso de Remsima® fue de 203.649 €, que equivaldría a tratar a 118 pacientes adicionales con infliximab biosimilar durante un año. Conclusiones: No existen diferencias significativas en la persistencia, tasa de retención y número de intensificaciones y desintensificaciones entre los pacientes naive que fueron tratados con Remicade® y aquellos tratados con Remsima®, siendo una alternativa eficaz, segura y económica en el tratamiento biológico de la colitis ulcerosa.

Abstract Objective: To compare the persistence, retention rate and prescription pattern of original infliximab and infliximab CT-P13 in biologic-naïve patients with ulcerative colitis. Method: This was an ambispective study of biologic-naive patients with ulcerative colitis who received non-simultaneous first-line treatment with Remicade ® (infliximab) and Remsima® (infliximab CT-P13) over a 10-year study period (2012-2021). Data on their age, weight, persistence, retention rate and on whether they required intensification or deintensification throughout the study period was collected. The real patient/year cost of Remicade® and Remsima® was determined individually based on the amounts administered during the study period. Results: 27 biologic-naive patients were treated with Remicade® and 53 with Remsima®. Neither patient group presented with differences in terms of weight and age. Persistence (median ± interquartile range) with Remicade® was 42.49 ± 57.48 months, as compared to 27.50 ± 58.50 months for Remsima®, without significant differences (p = 0.455). The retention rate at 6, 12, and 24 months was 81%, 63%, and 33%, respectively, for the Remicade® group and 71%, 47%, and 37%, respectively, for the Remsima® group. Nine subjects in the Remicade® group vs 11 patients in the Remsima® group were intensified. Regarding deintensification, five patients treated with Remicade® were deintensified, as compared with 7 patients on Remsima®. Savings obtained with the use of Remsima® amounted to 203,649 €, which would allow treating an additional 118 patients with biosimilar infliximab for one year. Conclusions: There are no significant differences in persistence, retention, and number of intensifications or deintensifications between biologic-naïve patients treated with Remicade® and those treated with Remsima®, the latter being an effective, safe and economical alternative for the treatment of ulcerative colitis.

https://doi.org/10.7399/fh.13232

Uma Manifestação Pouco Comum de Rejeição
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Resende, Carlos Xavier Correia de

; Diogo, Pedro Grilo

; Amorim, Sandra

; Pestana, Gonçalo

; Torres, José Pinheiro

; Macedo, Filipe

Arquivos Brasileiros de Cardiologia

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may 2022, Volume 118 N. 5 Pages 996 - 999

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210671

Guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force
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Tavares, Anna Carolina Faria Moreira Gomes

; Melo, Ana Karla Guedes de

; Cruz, Vítor Alves

; Souza, Viviane Angelina de

; Carvalho, Joana Starling de

; Machado, Ketty Lysie Libardi Lira

; Valadares, Lilian David de Azevedo

; Reis Neto, Edgard Torres dos

; Rezende, Rodrigo Poubel Vieira de

; Guimarães, Maria Fernanda Brandão de Resende

; Ferreira, Gilda Aparecida

; Braz, Alessandra de Sousa

; Vieira, Rejane Maria Rodrigues de Abreu

; Pinheiro, Marcelo de Medeiros

; Ribeiro, Sandra Lúcia Euzébio

; Bica, Blanca Elena Gomes Rios

; Baptista, Kátia Lino

; Costa, Izaias Pereira da

; Marques, Claudia Diniz Lopes

; Lopes, Maria Lúcia Lemos

; Martinez, José Eduardo

; Giorgi, Rina Dalva Neubarth

; Mota, Lícia Maria Henrique da

; Loures, Marcos Antônio Araújo da Rocha

; Paiva, Eduardo dos Santos

; Monticielo, Odirlei André

; Xavier, Ricardo Machado

; Kakehasi, Adriana Maria

; Pileggi, Gecilmara Cristina Salviato

Advances in Rheumatology

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2022, Volume 62 elocation 3

Abstract: En | Text: En | PDF: En

Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

https://doi.org/10.1186/s42358-022-00234-7

REFORMA DO ENSINO MÉDIO: A INSTITUCIONALIZAÇÃO DO APARTHEID SOCIAL NA EDUCAÇÃO
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Moraes, Carmen Sylvia Vidigal

; Ferretti, Celso João

; Pino, Ivany Rodrigues

; Leher, Roberto

; Almeida, Luana Costa

; Ximenes, Salomão Barros

; Dalbosco, Claudio Almir

; Souza, Sandra Maria Zákia Lian

; Zuin, Antônio Alvaro Soares

; Silveira, Adriana Aparecida Dragone

; Almeida, Ana Maria Fonseca de

; Trevisan, Anderson Ricardo

; Mazza, Débora

; Lima, Licínio Carlos Viana da Silva

; Amaral, Nelson Cardoso

; Goergen, Pedro

; Rambla, Xavier

; Sisto, Vicente

Educação & Sociedade

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2022, Volume 43 elocation e261875

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1590/es.261875

Posicionamento sobre Diagnóstico e Tratamento da Amiloidose Cardíaca – 2021
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Simões, Marcus V.

; Fernandes, Fabio

; Marcondes-Braga, Fabiana G.

; Scheinberg, Philip

; Correia, Edileide de Barros

; Rohde, Luis Eduardo P.

; Bacal, Fernando

; Alves, Silvia Marinho Martins

; Mangini, Sandrigo

; Biolo, Andréia

; Beck-da-Silva, Luis

; Szor, Roberta Shcolnik

; Marques Junior, Wilson

; Oliveira, Acary Souza Bulle

; Cruz, Márcia Waddington

; Bueno, Bruno Vaz Kerges

; Hajjar, Ludhmila Abrahão

; Issa, Aurora Felice Castro

; Ramires, Felix José Alvarez

; Coelho Filho, Otavio Rizzi

; Schmidt, André

; Pinto, Ibraim Masciarelli Francisco

; Rochitte, Carlos Eduardo

; Valicelli, Flávio Henrique

; Vieira, Marcelo Luiz Campos

; Mesquita, Cláudio Tinoco

; Ramos, Celso Dario

; Soares-Junior, José

; Romano, Minna Moreira Dias

; Mathias Junior, Wilson

; Garcia Junior, Marcelo Iório

; Montera, Marcelo Westerlund

; Melo, Marcelo Dantas Tavares de

; Silva, Sandra Marques e

; Garibaldi, Pedro Manoel Marques

; Alencar Neto, Aristóteles Comte de

; Lopes, Renato Delascio

; Ávila, Diane Xavier de

; Viana, Denizar

; Saraiva, José Francisco Kerr

; Canesin, Manoel Fernandes

; Oliveira, Glaucia Maria Moraes de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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sep 2021, Volume 117 N. 3 Pages 561 - 598

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210718 330 downloads

[SciELO Preprints] - ADOLESCENCE, EDUCATION AND INCLUSION: STUDENTS’ SOCIAL REPRESENTATIONS OF ADOLESCENTS WITH DOWN´S SYNDROME IN THEIR CLASSROOM
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Luz Neto, Rui Gonçalves da Cavalcanti , Anna Carolina Marques, Paulo Roberto Trigueiro de Brito Almeida , Hitallo Carlos Rodrigues de Xavier, Hiuryellen da Silva Heimer, Mônica Vilela Vieira, Sandra Conceição Maria

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Publication date: 2021-04-26

Abstract: En Es Pt

One's first social contacts beyond his family happens at school. How children and adolescents settle themselves at school influences their social relations during adulthood. Through a social inclusion perspective, this qualitative and interdisciplinary study aimed to get to know social representations developed by students regarding Down's Syndrome adolescents. Its basic referential theory was the Social Representation Theory. Data was collected through participant observation and semi-structured interviews with students who shared their classroom with adolescents with Down´s Syndrome. Data collected was submitted to methodological procedures of Speech Analysis, dialectically with Social Representation Theory. It was observed that relation between students with and without Down's Syndrome is positive and that the latter worries about how the former is treated by other people. Therefore, they stand for equity in adolescents with Down's Syndrome´s social relations. Nevertheless, the idea of capacitism was unveiled in representations, which is a great obstacle for inclusion.

En la escuela, los primeros contactos sociales del individuo tienen lugar más allá del núcleo familiar. La forma en que los niños y adolescentes se establecen en la escuela influye en la forma en que construyen relaciones sociales en la edad adulta. A través de la perspectiva de la inclusión social, este estudio, de carácter cualitativo, con un enfoque interdisciplinario, tuvo como objetivo conocer las representaciones sociales elaboradas por pares escolares sobre el adolescente con Síndrome de Down. El marco teórico básico de esta investigación fue la Teoría de las Representaciones Sociales. La recolección de datos se realizó a partir de la observación participante y entrevistas semiestructuradas realizadas a estudiantes que asistían al aula con un adolescente con Síndrome de Down. Los contenidos recolectados fueron sometidos a los procedimientos metodológicos de Análisis del Discurso, basados en una dialéctica con la Teoría de las Representaciones Sociales. Se observó que las relaciones entre pares son positivas y que se preocupan por la forma en que la sociedad los trata, por lo que defienden la equidad en las relaciones sociales con la persona con Síndrome de Down. Sin embargo, también se desveló el fenómeno del capacitismo, un gran obstáculo para el desafío de la inclusión social.

Na escola acontecem os primeiros contatos sociais do indivíduo para além do núcleo familiar. O modo como as crianças e os adolescentes se estabelece na escola influencia como constroem as relações sociais na vida adulta. Através da perspectiva da inclusão social, esse estudo, de natureza qualitativa, com aporte interdisciplina, teve como objetivo conhecer as representações sociais elaboradas por pares escolares a respeito do adolescente com Síndrome de Down. O referencial teórico basilar para esta pesquisa foi a Teoria das Representações Sociais. A coleta de dados se deu com base na observação participante e em entrevistas semiestruturadas realizadas com estudantes que frequentavam sala de aula com uma adolescente com Síndrome de Down. Os conteúdos coletados foram submetidos aos procedimentos metodológicos da Análise do Discurso, a partir de uma dialética com a Teoria das Representações Sociais. Observou-se que as relações entre os pares são positivas e que se preocupam com o modo que a sociedade lida com eles, portanto, defendem a equidade nas relações sociais com a pessoa com Síndrome de Down. Entretanto, também desvelou-se o fenômeno do capacitismo, um grande obstáculo ao desafio da inclusão social.

https://doi.org/10.1590/SciELOPreprints.2138

APLICAÇÃO DO PROGRAMA DE REGIONALIZAÇÃO DO TURISMO EM UMA INSTÂNCIA DE GOVERNANÇA REGIONAL NO ESTADO DO RIO GRANDE DO SUL, BRASIL
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XAVIER, THIAGO REIS

; TOTTI, KÉZIA ÁVILA SOARES

; RADDATZ, SANDRA MARI FLORES

Turismo: Visão e Ação

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apr 2021, Volume 23 N. 1 Pages 86 - 109

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: O presente estudo tem como objetivo analisar os mecanismos de governança turística do Fórum Regional de Turismo - Região Central, Rio Grande do Sul, Brasil. Trata-se de uma Instância de Governança Regional instituída para atender aos objetivos do Plano Nacional de Turismo (PNT) e do Programa de Regionalização do Turismo (PRT), e inserir a Região Central do Rio Grande do Sul no mapa do turismo brasileiro elaborado pelo Ministério do Turismo. Para tal, foi realizado um estudo de caso, qualitativo e descritivo, conduzido por meio de um roteiro de entrevistas semiestruturado elaborado a partir do modelo teórico proposto por Xavier (2016). Ele é organizado em seis categorias que abordam variáveis como: contexto histórico e cultural (1); formalização e estrutura, normas e regras (2); interação entre os atores e uso dos recursos locais (3); poder, confiança, conflito e interesses (4); transparência e prestação de contas (5); e Padrão de Arranjo Institucional (6). Como fontes foram selecionados três atores que atuaram como coordenadores do Fórum Regional de Turismo entre 2011 e 2018. A interpretação e a análise dos dados seguiram a metodologia de análise de conteúdo. Como resultados, observou-se que a falta de um Estatuto e de Plano Regional de Turismo prejudica as ações do Fórum, especialmente no que diz respeito à obtenção de recursos financeiros para desenvolvimentos de maiores práticas na região e elaboração de práticas conjuntas visando ao desenvolvimento do turismo regional. Sugerem-se a elaboração de um Plano Regional e a criação do estatuto interno, para que se possam viabilizar a formalização e as práticas de cooperação no âmbito do Fórum.

ABSTRACT: This study aims to analyze the mechanisms tourist governance of the Regional Tourism Forum, located in the Rio Grande do Sul Central Region, Brazil. The study focuses on a Regional Governance entity created through the National Tourism Plan (PNT) and the Tourism Regionalization Program (PRT), and adds the Central Region of Rio Grande do Sul to the Brazilian Tourism Map proposed by the Ministry of Tourism. A qualitative and descriptive case study was conducted. A semi-structured interview script was used, based on the theoretical model proposed by Xavier (2016). This model is organized into six categories: historical and cultural context (1); formalization and structure, norms and rules (2); interaction between actors and use of local resources (3); power, trust, conflict and interests (4); transparency and accountability (5); and Forms of Network Governance (6). Three coordinators of the Regional Tourism Forum were interviewed between 2011 and 2018. The data were analyzed using the methodology of content analysis. The results showed the lack of internal bylaws and Regional Tourism Plan. This makes it difficult to obtain financial resources to develop efficient practices in the region, and to elaborate joint practices of tourism regional development. It is therefore suggested that a Regional Plan and internal bylaws be created, as this would enable formalization and cooperation in the Forum.

RESUMEN: Este estudio tiene como objetivo analizar los mecanismos de gobernanza turística del Foro Regional de Turismo - Región Central, Rio Grande do Sul, Brasil. Es una Instancia de Gobernanza Regional establecida para cumplir con los objetivos del Plan Nacional de Turismo (PNT) y el Programa de Regionalización Turística (PRT), e insertar la Región Central de Rio Grande do Sul en el mapa turístico brasileño elaborado por el Ministro de Turismo. Para ello, se realizó un estudio de caso cualitativo y descriptivo, realizado a través de un guión de entrevista semiestructurado elaborado a partir del modelo teórico propuesto por Xavier (2016). Este se organiza en seis categorías que abordan variables como: contexto histórico y cultural (1); formalización y estructura, normas y reglas (2); interacción entre actores y uso de recursos locales (3); poder, confianza, conflicto e intereses (4); transparencia y rendición de cuentas (5); y Norma de arreglo institucional (6). Como fuentes, se seleccionaron tres actores que actuaron como coordinadores del Foro Regional de Turismo, entre 2011 y 2018. La interpretación y los análisis de los datos siguió la metodología de análisis de contenido. Como resultado, se observó que la falta de un Estatuto y un Plan Regional de Turismo perjudica las acciones del Foro, especialmente en lo que respecta a la obtención de recursos financieros para el desarrollo de mayores prácticas en la región y el desarrollo de prácticas conjuntas orientadas a turismo regional. Se sugiere la elaboración de un Plan Regional y la creación del estatuto interno, de manera que se posibiliten las prácticas de formalización y cooperación dentro del Foro.

https://doi.org/10.14210/rtva.v23n1.p86-109 242 downloads

The way of life of the unhoused people as an enhance for COVID-19 care
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Brito, Cláudia

; Silva, Lenir Nascimento da

; Xavier, Carlos Cesar Leal

; Antunes, Valeska Holst

; Costa, Marcelo Soares

; Filgueiras, Sandra Lucia

Revista Brasileira de Enfermagem

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2021, Volume 74 Suppl. 1 elocation e20200832

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Analisar o modo de vida da População em Situação de Rua para potencializar o cuidado em saúde na pandemia. Métodos: Pesquisa qualitativa, interdisciplinar, com observação participante e 24 entrevistas com população em situação de rua. Categorias empíricas e busca bibliográfica sobre essa população e COVID-19 pautaram proposições simples voltadas ao cuidado. Resultados: O grupo de maior risco para COVID-19 faz uso compulsivo de drogas; passa fome constantemente; interrompe tratamento medicamentoso para Tuberculose, HIV e Diabetes; tem subdiagnóstico de Depressão; tem dificuldade de abrigamento; usa drogas inalatórias. Esse modo de vida aumenta risco de agravamento da COVID-19 e impõe maiores desafios aos serviços de saúde. Diversas propostas para orientar o cuidado levaram em conta esses resultados e a nova rotina impressa pela pandemia. Considerações Finais: O modo de vida da população estudada ampliou sua vulnerabilidade na pandemia, bem como a percepção de risco de transmissão da doença pela população em geral.

ABSTRACT Objective: To analyze the way of life of the unhoused people to enhance health care in the pandemic. Methods: A qualitative, interdisciplinary research, with participant observation and 24 interviews with the unhoused people. Empirical categories and bibliographic search on this population and COVID-19 guided simple actions aimed at care. Results: The group at greatest risk for COVID-19 use drugs compulsively; starves constantly; discontinues drug treatment for tuberculosis, HIV, and diabetes; has underdiagnosis of Depression; has difficulty sheltering and uses inhaled drugs. This way of life increases the risk of worsening COVID-19 and brings great challenges to health services. Several proposals to guide care considered these results and the new routine caused by the pandemic. Final considerations: The way of life of the studied population increased their vulnerability in the pandemic, as well as the perception of risk of disease transmission by the population in general.

RESUMEN Objetivo: Analizar el modo de vida de la población en situación de calle (PSC) para potenciar el cuidado en salud en la pandemia. Métodos: Investigación cualitativa, interdisciplinaria, con observación participante, y 24 entrevistas con población en situación de calle. Categorías empíricas y búsqueda bibliográfica sobre dicha población y COVID-19 determinaron propuestas simples orientadas al cuidado. Resultados: El grupo más vulnerable a COVID-19 usa drogas compulsivamente, pasa hambre, interrumpe tratamiento médico para tuberculosis, VIH y diabetes; tiene subdiagnóstico de depresión, dificultad para hallar refugio y usa drogas inhalantes. Dicho modo de vida incrementa el riesgo de agravamiento del COVID-19, imponiendo mayores desafíos a los servicios de salud. Diversas propuestas de orientación del cuidado consideraron estos resultados y las nuevas rutinas impuestas por la pandemia. Consideraciones finales: El modo de vida de la población estudiada incrementó su vulnerabilidad en pandemia, así como la percepción de riesgo de transmisión de la enfermedad a la población en general.

https://doi.org/10.1590/0034-7167-2020-0832 751 downloads

10.

O FUNDEB PERMANENTE EM TEMPOS DE DESCONSTRUÇÃO E DESFAZIMENTO: MOBILIZAÇÃO E UM BASTA VEEMENTE
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Amaral, Nelson Cardoso

; Souza, Sandra Maria Zákia Lian

; Ximenes, Salomão Barros

; Pino, Ivany Rodrigues

; Almeida, Luana Costa

; Goergen, Pedro

; Ferretti, Celso João

; Zuin, Antonio Álvaro Soares

; Moraes, Carmen Sylvia Vidigal

; Silveira, Adriana Dragone

; Lima, Licínio Carlos Viana da Silva

; Rambla, Xavier

; Trevisan, Anderson Ricardo

Educação & Sociedade

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2021, Volume 42 elocation e247741

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1590/es.247741 1364 downloads

11.

Genotypic superiority of Psidium Guajava S1 families using mixed modeling for truncated and simultaneous selection
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Ambrósio, Moisés

; Viana, Alexandre Pio

; Ribeiro, Rodrigo Moreira

; Preisigke, Sandra Costa

; Cavalcante, Natan Ramos

; Silva, Flavia Alves da

; Torres, Géssica Xavier

; Sousa, Carlos Misael Bezerra de

Scientia Agricola

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2021, Volume 78 N. 2 elocation e20190179

Abstract: En | Text: En | PDF: En

ABSTRACT: The purpose of this study was to conduct selection, genetic parameter estimation, and prediction of genetic values for 18 S1 families of guava trees using mixed model methodology and simultaneous selection of traits by means of the additive selection index, multiplicative selection index, and mean rank adapted from Mulamba. All families analyzed were obtained by means of self-fertilization of superior genotypes (full siblings) from the genetic breeding program of guava trees at the Universidade Estadual do Norte Fluminense. An experimental randomized block design with 18 S1 families, three replicates, and ten plants per plot was used. A total of 540 genotypes (individual plants) of guava tree were evaluated. Genetic parameter estimation and selection of the best genotypes based on the genetic value were performed using the statistical procedure, from the Selegen-REML/BLUP program. The analyses of the additive selection index, multiplicative selection index, and the sum of rank adapted from Mulamba were also performed under the Selegen program. During the evaluation by the individual BLUPs, families 1, 12, 4, 6, and 8 contributed to most of the genotypes selected for the traits under evaluation, suggesting their significant potential to generate high quality and high yield genotypes. In the selection indexes via mixed models, the multiplicative index showed higher values for genetic gains (74 %), followed by the mean rank index adapted from Mulamba (19 %), and the additive index (2 %).

https://doi.org/10.1590/1678-992x-2019-0179 467 downloads

12.

Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil
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Pileggi, Gecilmara Salviato

; Ferreira, Gilda Aparecida

; Gomides Reis, Ana Paula Monteiro

; Reis Neto, Edgard Torres

; Abreu, Mirhelen Mendes

; Albuquerque, Cleandro Pires

; Araújo, Nafice Costa

; Bacchiega, Ana Beatriz

; Bianchi, Dante Valdetaro

; Bica, Blanca

; Bonfa, Eloisa Duarte

; Borba, Eduardo Ferreira

; Brito, Danielle Christinne Soares Egypto

; Duarte, Ângela Luzia Branco Pinto

; Santo, Rafaela Cavalheiro Espírito

; Fernandes, Paula Reale

; Guimarães, Mariana Peixoto

; Gomes, Kirla Wagner Poti

; Kakehasi, Adriana Maria

; Klumb, Evandro Mendes

; Lanna, Cristina Costa Duarte

; Marques, Claudia Diniz Lopes

; Monticielo, Odirlei André

; Mota, Licia Maria Henrique

; Munhoz, Gabriela Araújo

; Paiva, Eduardo Santos

; Pereira, Helena Lucia Alves

; Provenza, José Roberto

; Ribeiro, Sandra Lucia Euzébio

; Rocha Junior, Laurindo Ferreira

; Sampaio, Camila Santana Justo Cintra

; Sampaio, Vanderson Souza

; Sato, Emília Inoue

; Skare, Thelma

; de Souza, Viviane Angelina

; Valim, Valeria

; Lacerda, Marcus Vinícius Guimarães

; Xavier, Ricardo Machado

; Pinheiro, Marcelo Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 60

Abstract: En | Text: En | PDF: En

Abstract Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS-CoV-2 outbreak. Our aim was to compare the occurrence of COVID-19 between rheumatic disease patients on hydroxychloroquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil. Methods: This baseline cross-sectional analysis is part of a 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. All information regarding COVID-19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web-based platform using telephone calls from physicians and medical students. COVID-19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann-Whitney, Chi-square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward-stepwise method for the presence of COVID-19. Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total, 1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk factor significantly associated with a COVID-19 diagnosis was lung disease (OR 1.63; 95% CI 1.03-2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19-6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31-3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46-0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID-19 to household cohabitants, suggesting a lack of any protective role against SARS-CoV-2 infection. Trial registration Brazilian Registry of Clinical Trials (ReBEC; RBR - 9KTWX6).

https://doi.org/10.1186/s42358-021-00217-0 22 downloads

13.

Identificación y reconocimiento de enfermedades profesionales en siete hospitales públicos de España
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Palma-Vasquez, Claudia

; Serra, Consol

; Delclos, George L

; Ramada, José M

; Benavides, Fernando G

; Carreras, Rosa

; Orpella, Xavier

; Taboada, Isabel

; Diego, Carmen

; Campo, Mª Teresa del

; Castañón, Juan

; González, Vicenç

; Beltrán, Ana

; López, Alonso

; Nieto, Sandra

; Cendón, Laia

Revista de la Asociación Española de Especialistas en Medicina del Trabajo

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2021, Volume 30 N. 2 Pages 185 - 194

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Background: Under-reporting and recognition of occupational disease (OD) is a secular problem in Spain and other European countries. The burden of occupational disease in Spain project (CEPS) aims to contribute. Objective: To describe the process of identification and recognition of OD in seven Spanish between 2017 and 2020. Material and Methods: In the seven hospitals that participate in the study an occupational pathology unit (OPU) was created. The OPU encouraged the healthcare services to identify possible OD treated in the hospital. The patients confirmed by the OPU were accompanied in the recognition process. Results: 308 cases were referred in this period and 154 OD was confirmed (62%). Of these, 78 have been recognized (65%). The confirmation rate (confirmed/ referred cases) varied according to hospitals (from 25% at the Badalona Serveis Assistencials to 100% at the Hospital Universitario Fundación Jiménez Díaz) and diagnosis groups (from 13% for musculoskeletal disorders to 100% for various pathologies). The recognition rate (confirmed/ recognized cases) varied according to hospitals, diagnosis, sex and age, being higher in women, aged ≥ 55 years and diagnosed with various pathologies (ocular, infectious, mental, among others). Conclusion: OPU contribute significantly in the process of identification and recognition of OD, which the patients might not have obtained otherwise.

RESUMEN. Antecedentes : La infra-notificación y reconocimiento de enfermedad profesional (EP) es un problema secular en España y demás países europeos. El proyecto de Carga de la Enfermedad Profesional en España (CEPS) pretende contribuir a resolver este problema. Objetivo: Describir el proceso de identificación y reconocimiento de EP en siete hospitales españoles entre 2017 y 2019. Material y Métodos: En los siete hospitales que participan en el estudio se creó una unidad de patología laboral (UPL) la cual estimulaba en los servicios asistenciales la identificación de posibles EP atendidas en el hospital. Los pacientes confirmados por la UPL fueron acompañados en el proceso de reconocimiento. Resultados: En este periodo fueron derivados 308 casos, y en 154 (62%) se confirmó la sospecha EP. De éstos, 78 (65%) han sido reconocidos. La tasa de confirmación (casos confirmados/ derivados) varió según hospitales (de un 25% en el Badalona Serveis Assistencials a un 100% en el Hospital Universitario Fundación Jiménez Díaz) y grupos de diagnósticos (de un 13% para trastornos musculoesqueléticos a un 100% para patologías varias). La tasa de reconocimiento (casos confirmados/casos reconocidos) varió según centro, diagnóstico, sexo y edad, siendo más alta en mujeres, con ≥ 55 años y diagnosticados con patologías varias (oculares, infecciosas, mentales, entre otras). Conclusión: Las UPL contribuyen significativamente en el proceso de identificación y reconocimiento de EP, lo que los pacientes posiblemente no hubieran obtenido de otra forma.

14.

Identificación y reconocimiento de enfermedades profesionales en siete hospitales públicos de España
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Palma-Vasquez, Claudia

; Serra, Consol

; Delclos, George L

; Ramada, José M

; Benavides, Fernando G

; Carreras, Rosa

; Orpella, Xavier

; Taboada, Isabel

; Diego, Carmen

; Campo, Mª Teresa del

; Castañón, Juan

; González, Vicenç

; Beltrán, Ana

; López, Alonso

; Nieto, Sandra

; Cendón, Laia

Revista de la Asociación Española de Especialistas en Medicina del Trabajo

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2021, Volume 30 N. 2 Pages 185 - 194

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

15.

DIAGNOSTIC TESTS AND CLINICAL CHARACTERISTICS OF COVID-19 IN CHILDREN: AN INTEGRATIVE REVIEW
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Nunes, Michelle Darezzo Rodrigues

; Pacheco, Sandra Teixeira de Araújo

; Costa, Cícero Ivan Alcantara

; Silva, Jaciane Alexandre da

; Xavier, Welker da Silva

; Victória, Juliana Zambrano

Texto & Contexto - Enfermagem

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dec 2020, Volume 29 elocation e20200156

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to identify in nursing literature scientific production on tests and clinical characteristics of COVID-19 in children and discuss the role of nursing in their care. Methods: an integrative review, which took place between April and June 2020, at Web of Science, CINAHL, BDENF, IBECS, LILACS, MEDLINE (via PubMed) to answer the guiding question: what do research articles on COVID-19 in children reveal? Original research articles published from January to May 2020 were included. Studies without research methodology (case reports, reflection, recommendations), review articles, studies focusing on other themes or conducted exclusively with neonates, infants, adolescents, and adults were excluded. Results: database search found 314 references. After exclusions, 59 studies were selected to be read in full. Of these, 14 articles were selected to compose this review, empirically grouped according to their similarities into two categories: Tests used in COVID-19 in children and Main clinical findings of COVID-19 in children. Conclusion: studies emphasize clinical tests and findings of COVID-19 in children; therefore, the role of nursing at the time of preparation and performance of such tests stands out, since they are an instrument for assessment and follow-up of children with coronavirus as well as in the promotion of adequate and qualified care to minimize the signs and symptoms of this disease, with a view to prompt restoration of their health.

RESUMEN Objetivo: identificar en la literatura la producción científica sobre exámenes y manifestaciones clínicas de COVID-19 en niños y discutir el papel de la enfermería en su atención. Métodos: revisión integradora, cuya búsqueda tuvo lugar entre abril y junio de 2020, en las bases de datos de Web of Science, CINAHL, BDENF, IBECS, LILACS, MEDLINE (a través de PubMed) para responder a la pregunta orientadora: lo que revelan los artículos de investigación sobre COVID -19 en niños? Se incluyeron artículos de investigación originales, publicados de enero a mayo de 2020. Estudios sin metodología de investigación (informes de casos, reflexión, recomendaciones), artículos de revisión, estudios que se centraron en otros temas o se llevaron a cabo exclusivamente con recién nacidos, bebés, población de adolescentes y adultos. Resultados: las búsquedas en las bases de datos buscadas capturaron 314 referencias. Después de las exclusiones, se seleccionaron 59 estudios para ser leídos en su totalidad; de estos, se seleccionaron 14 artículos para componer esta revisión, agrupados empíricamente, de acuerdo con sus similitudes, en dos categorías: Exámenes utilizados en COVID-19 en niños; y Principales hallazgos clínicos en COVID-19 en niños. Conclusión: los estudios enfatizan los exámenes COVID-19 y los hallazgos clínicos en niños; por lo tanto, el papel de la enfermería se destaca al preparar y realizar estos exámenes, ya que son un instrumento para evaluar y monitorear a los niños con COVID-19, así como para promover una atención adecuada y calificada para minimizar los signos y síntomas de esta enfermedad. enfermedad, con miras a la pronta restauración de su salud.

RESUMO Objetivo: identificar na literatura a produção científica sobre exames e manifestações clínicas da COVID-19 em crianças e discutir o papel da enfermagem no atendimento a elas. Métodos: revisão integrativa, cuja busca ocorreu entre abril e junho de 2020, nas bases de dados Web of Science, CINAHL, BDENF, IBECS, LILACS, MEDLINE (via PubMed) para responder à questão norteadora: “o que revelam os artigos de pesquisa sobre a COVID-19 em crianças?”. Foram incluídos artigos de pesquisa originais, publicados de janeiro a maio de 2020. Excluíram-se estudos sem metodologia de pesquisa (relatos de caso, reflexão, recomendações), artigos de revisão, estudos que focavam outras temáticas ou realizados exclusivamente com neonatos, lactentes, adolescentes e população adulta. Resultados: as buscas nas bases de dados pesquisadas capturaram 314 referências. Após as exclusões, selecionaram-se 59 estudos para serem lidos na íntegra; destes, 14 artigos foram selecionados para compor esta revisão, agrupados empiricamente, conforme suas similaridades, em duas categorias: exames utilizados na COVID-19 em crianças e principais achados clínicos da COVID-19 em crianças. Conclusão: os estudos enfatizam os exames e achados clínicos da COVID-19 em crianças; logo, destaca-se o papel da enfermagem no momento do preparo e realização desses exames, uma vez que se constituem instrumento de avaliação e acompanhamento da criança com Coronavírus, bem como na promoção de um adequado e qualificado cuidado para minimizar os sinais e sintomas dessa doença, com vistas ao pronto restabelecimento de sua saúde.

https://doi.org/10.1590/1980-265x-tce-2020-0156 5 downloads

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