Resumen La experiencia colombiana con la justicia transicional (TJ) es anterior al reciente acuerdo de paz entre el gobierno de Colombia y las FARC. Colombia representa un caso único de esfuerzos significativos hacia TJ antes de que se lograra un fin negociado del conflicto armado. Las leyes, instituciones y programas que implementaron estos mecanismos anteriores de TJ sentaron las bases para un entorno posterior al conflicto, a pesar de que su implementación tuvo lugar en medio de un conflicto en curso. Cada administración ha podido identificar áreas de mejora para los mecanismos que ya existen y los ha fortalecido mediante cambios en la estructura normativa o mediante la creación de nuevas instituciones. Después de un breve resumen de la evolución del concepto de los mecanismos de TJ y TJ, el documento proporciona una breve descripción de los casos comparativos de TJ en América Central. Luego se considera el caso colombiano, examinando primero las iniciativas de TJ anteriores al acuerdo de paz, antes de centrarse en los mecanismos de TJ negociados entre el gobierno colombiano y las FARC. Analizar el caso colombiano en una perspectiva tanto histórica como comparativa puede ayudar a arrojar luz sobre algunos de los desafíos clave que se avecinan para la responsabilidad de TJ en Colombia.

Abstract Colombian experience with transitional justice (TJ) significantly precedes the recent peace agreement between the Colombian government and the FARC. Colombia presents a unique case of significant efforts towards TJ before a negotiated end of the armed conflict was achieved. As such, each prior experience with TJ informed posterior efforts. After a brief summary of the evolution of the concept of TJ and TJ mechanisms, the paper provides a brief overview of comparative cases of TJ in Central America. Then, the Colombian case is considered, first examining TJ initiatives that preceded the peace agreement, before focusing on TJ mechanisms negotiated between the Colombian government and FARC. Analyzing the Colombian case in both historical and comparative perspective can help to shed light on some of the key challenges that lay ahead for TJ accountability in Colombia.

Allergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood. With an increasing knowledge of underlying mechanisms, there is now more potential to target the inflammatory process rather than the overt symptoms. This focuses attention on the role of leukocytes especially Th2 lymphocytes that regulate allergic inflammation and effector cells where eosinophils have received much attention. Eosinophils are thought to be important based on the high numbers that are recruited to sites of allergic inflammation and the potential of these cells to effect both tissue injury and remodelling. It is hoped that future therapy will be directed towards specific leukocyte types, without overtly compromising essential host defence responses. One obvious target is leukocyte recruitment. This necessitates a detailed understanding of underlying mechanisms, particularly those involving soluble che-moattractants signals and cell-cell adhesion molecules.