Abstract: This paper presents an experience of the analysis and management of scientific and technological information for directing research, development and innovation efforts in the Universidad de La Frontera. The study's objective is to identify and envision research fields in the University's scientific production appearing in published scientific research and recorded in the public financing systems. The sample includes publications and projects published between 2007 and 2011. The task of research field identification is approached through the complementary use of "Co-words Analysis"; "Expert Validation Methodology" and "Thematic Analysis of Elementary Contexts"; in conjunction with social network visualization tools. Information regarding the management of information and scientific and technological capabilities are among the study’s findings.

Resumen: El artículo presenta una experiencia de análisis y gestión de información científica y tecnológica para la focalización de la Investigación, Desarrollo e Innovación (I+D+i) en la Universidad de La Frontera, Chile. El objetivo fue identificar y visualizar áreas temáticas de la producción científica de la universidad visibles en el sistema de publicación científica y en el sistema de financiamiento público. La muestra consideró publicaciones y proyectos disponibles durante el periodo 2007-2011. La identificación de las áreas temáticas se aborda desde la utilización complementaria del método de las palabras asociadas y la validación de expertos, mediante el análisis temático de contextos elementales y la utilización de herramientas de visualización de redes sociales. Se extraen aprendizajes de gestión de información y gestión de capacidades científicas y tecnológicas.

Since the 1970s, the establishment and development of the biotech industry has improved exponentially, allowing the commercial production of biopharmaceutical proteins. Nowadays, new recombinant protein production is considered a multibillion-dollar market, in which about 25% of commercial pharmaceuticals are biopharmaceuticals. But to achieve a competitive production process is not an easy task. Any production process has to be highly productive, efficient and economic. Despite that the perfect host is still not discovered, several research groups have chosen Pichia pastoris as expression system for the production of their protein because of its many features. The attempt of this review is to embrace several research lines that have adopted Pichia pastoris as their expression system to produce a protein on an industrial scale in the health care industry.

The innovation in industrial process with impact in the efficient production is the major challenge for actual industry. A high numerous of enzymes are utilized in at different level of process; the search for new alternatives with better characteristic has become a field of study of great interest, the recombinant protein achievement in a different host system is an alternative widely assessed for production of this. The microorganism Pichia pastoris has been used like a successful expression system in diverse areas, improved the yield and extraction-recovery of the product expressed. The reported of diverse authors in the production of enzymes with different application in industry is varied, in this review the different industry areas and the characteristic of the enzymes produced are detailed.