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Exposição ao gás cloro e padrões evolutivos da síndrome da disfunção reativa das vias aéreas: uma revisão sistemática
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Vianna, Angelica dos Santos

; Bhering, Ana Clara Poyares de Mello

; Silva, Fernanda Antunes Cavalcante da

; Vianna, Rosa Cristina dos Santos

; Santos, Aline de Souza Espindola

Revista Brasileira de Saúde Ocupacional

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2023, Volume 48 elocation e12

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: chlorine is the most irritant gas to which people are commonly exposed to daily. One of its toxic effects is reactive airway dysfunction syndrome (RADS). Objective: this study aims to summarize the evidence from the evolutive patterns of RADS. Methods: this systematic review study was conducted using the databases of the University of São Paulo repository, BVS/LILACS, PubMed/Medline, and SciELO. Studies from September 1985 to July 2021 with “chlorine” and “occupational asthma” as descriptors, associated with “reactive airway dysfunction syndrome” or “irritant-induced asthma,” were included. These articles were assessed by two independent reviewers. The study’s quality was assessed using the Joanna Briggs checklist. Results: a total of 22 studies were retrieved, including 11 case series, 8 case reports, and 3 cross-sectional studies. The selected studies covered 1.335 participants from 11 countries, and only 170 had a diagnosis of RADS with documented evolution. Of these, 115 (65%) were due to occupational exposure. The most frequent RADS evolutive pattern was the long-term persistence of symptoms, spirometric alterations, and/or bronchial hyperresponsiveness, mainly in the occupational setting. A lack of standardization of adequate information reporting was found. Conclusions: chronicity was the most frequent RADS evolutive pattern.

Resumo Introdução: o cloro é o gás irritante a que as pessoas estão comumente expostas no cotidiano. Um dos seus efeitos tóxicos é a síndrome da disfunção reativa das vias aéreas (SDRA). Objetivo: resumir as principais evidências dos padrões evolutivos da SDRA. Métodos: Revisão sistemática da literatura de artigos publicados entre setembro de 1985 e julho de 2021 no repositório da Universidade de São Paulo (USP) e nas bases BVS/LILACS, PubMed/Medline e SciELO. Foram utilizados os descritores “cloro” e “asma ocupacional” associados à “síndrome da disfunção reativa das vias aéreas” ou “asma induzida por irritantes”. Dois revisores independentes selecionaram e avaliaram a qualidade dos estudos, com apoio do checklist do Instituto Joanna Briggs. Resultados: selecionaram-se 22 estudos: 11 séries de casos, oito relatos de caso e três estudos transversais. Os estudos selecionados abrangeram 1.335 participantes de 11 países, e apenas 170 tiveram diagnóstico de SDRA com evolução documentada. Destes, 115 (65%) foram devido à exposição ocupacional. Os padrões evolutivos mais frequentes foram persistência prolongada dos sintomas, alterações espirométricas e/ou hiper-responsividade brônquica, principalmente no ambiente ocupacional. Observou-se falta de padronização no relato de informações adequadas. Conclusões: a cronicidade foi o padrão evolutivo da SDRA mais frequente. Houve falta de informação apropriada que impediu uma análise adequada dos resultados.

https://doi.org/10.1590/2317-6369/30021pt2023v48e12

Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of erythema nodosum leprosum with thalidomide
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Costa, Perpétua do Socorro Silva

; Maciel-Fiuza, Miriãn Ferrão

; Kowalski, Thayne Woycinck

; Fraga, Lucas Rosa

; Feira, Mariléa Furtado

; Camargo, Luís Marcelo Aranha

; Caldoncelli, Daniele Iop de Oliveira

; Silveira, Maria Irismar da Silva

; Schuler-Faccini, Lavínia

; Vianna, Fernanda Sales Luiz

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220039

Abstract: En | Text: En | PDF: En

BACKGROUND Erythema nodosum leprosum (ENL) is an acute and systemic inflammatory reaction of leprosy characterised by painful nodules and involvement of various organs. Thalidomide is an immunomodulatory and anti-inflammatory drug currently used to treat this condition. Cereblon (CRBN) protein is the primary target of thalidomide, and it has been pointed out as necessary for the efficacy of this drug in others therapeutics settings. OBJECTIVES In this study, we aimed to evaluate the influence of CRBN gene variants on the dose of thalidomide as well as its adverse effects during treatment of ENL. METHODS A total of 103 ENL patients in treatment with thalidomide were included in this study. DNA samples were obtained from saliva and molecular analysis of CRBN gene were performed to investigate the variants rs1620675, rs1672770 and rs4183. Different genotypes of CRBN variants were evaluated in relation to their influence on the dose of thalidomide and on the occurrence of adverse effects. FINDINGS No association was found between CRBN variants and thalidomide dose variation. However, the genotypes of rs1672770 showed association with gastrointestinal effects (p = 0.040). Moreover, the haplotype DEL/C/T (rs4183/rs1672770/rs1620675) was also associated with gastrointestinal adverse effects (p = 0.015). MAIN CONCLUSIONS Our results show that CRBN variants affect the treatment of ENH with thalidomide, especially on the adverse effects related to the drug.

https://doi.org/10.1590/0074-02760220039

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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dec 2021, Volume 36 N. 6 Pages 725 - 735

Abstract: En | Text: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

Morphological characterization and productivity estimates of Acrocomia totai Mart. (Arecaceae) – a sustainable alternative of extractivism and cultivation
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Vianna, Suelen Alves

; Domenech, Helen Liepkan Maranhão

; Silva, Rosa Helena da

; Colombo, Carlos Augusto

; Pott, Arnildo

Revista Brasileira de Fruticultura

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2021, Volume 43 N. 1 elocation e-730

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A palmeira Acrocomia totai pode ser encontrada em áreas do Cerrado e Pantanal, no Brasil, Argentina, Bolívia e Paraguai. Seus frutos são utilizados por comunidades tradicionais e rurais como meio de subsistência ou como fonte de renda. Da importância deste recurso genético, foram realizadas a avaliação de caracteres morfológicos e agronômicos, e a estimativa da densidade populacional em duas fisionomias do Pantanal. Foi encontrada variação em todos os caracteres analisados, tais como: a densidade de espinhos no estipe, a coloração das folhas, do epicarpo e do mesocarpo. O número médio de frutos por cacho foi de 392.30±134.53, massa fresca (g) de um fruto inteiro de 15.50±3.87 e teor de óleo (%) no mesocarpo de 14.94±8.06. A densidade populacional variou de 48 pls.ha-1 em área de ‘campo sujo’ a 287 pls.ha-1 em áreas de ‘campo limpo’. Estima-se a produção por hectare de 8.65 t de frutos, 4.77 t de polpa e 270 kg de óleo, em áreas de ‘campo sujo’, e 1.45 t de frutos, 0.8 t de polpa e 50 kg de óleo, em áreas de ‘campo limpo’. Os dados demonstram a possibilidade de exploração rentável da espécie via extrativismo ou cultivo. A variação encontrada pode ser útil à taxonomia do gênero, a programas de melhoramento e à conservação.

Abstract The Acrocomia totai palm can be found in areas of Cerrado and Pantanal in Brazil, Argentina, Bolivia and Paraguay. Its fruits are used by traditional and rural communities for subsistence or income source. Given the relevance of this genetic resource, we assessed the morphological and agronomic characters and estimated the population density in two physiognomies of the Pantanal. We found variation in all analyzed characters, such as the density of spines on the stipe, coloration of leaves, epicarp and mesocarp. The average number of fruits per bunch was 392.30±134.53, fresh mass (g) of the whole fruit of 15.50±3.87 and, the mesocarp oil content (%) of 14.94±8.06. The population density varied between 48 pls.ha-1 in area of shrubby grassland to 287 pls.ha-1 in open grassland. We estimated yields per hectare of 8.65 t of fruits, 4.77 t of pulp and 270 kg of oil in areas of shrubby grassland and 1.45 t of fruits, 0.8 t of pulp and 50 kg of oil in areas of open grassland. The data demonstrate the potential of profitable exploitation of the species in extractive or cultivation. The variation found can be useful for the genus taxonomy, breeding and conservation programs.

https://doi.org/10.1590/0100-29452021730 712 downloads

COVID-19 during pregnancy and adverse outcomes: Concerns and recommendations from The Brazilian Teratology Information Service
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Vianna, Fernanda Sales Luiz

; Fraga, Lucas Rosa

; Abeche, Alberto Mantovani

; Silva, André Anjos Da

; Sanseverino, Maria Teresa Vieira

; Schuler-Faccini, Lavinia

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20200224

Abstract: En | Text: En | PDF: En

Abstract SARS-CoV-2 virus was first identified in the beginning of 2020 and has spread all over the world, causing the Coronavirus Disease 2019 (COVID-19) pandemic. The virus is a member of the Coronavirus family, which includes viruses that cause common cold, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). MERS and SARS are known by causing adverse events in pregnancy. Considering that SARS-CoV-2 is a new infection agent, little is known about the risk of its infection to human embryo/fetal development. However, SARS and MERS were associated with negative outcomes, such as miscarriage, preterm birth, intrauterine growth restriction and perinatal death. Here, we raise concerns and possibilities related the harmful potential of SARS-CoV-2 and COVID-19 to pregnancy, discussing symptoms, immunological changes during pregnancy, SARS-CoV-2 mutation rate (and the risks related to it). Finally, we point out recommendations to be performed by the scientific community and health care workers in order to identify and to manage potential risks to pregnant women and their babies.

https://doi.org/10.1590/1678-4685-gmb-2020-0224 1714 downloads

A filha de Cristóvão Colombo e os tortos das américas: diálogo interamericano e reinvenção de identidades em práticas discursivas outsiders
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Vianna Neto, Arnaldo Rosa

Alea: Estudos Neolatinos

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aug 2020, Volume 22 N. 2 Pages 152 - 171

Abstract: Pt En Fr | Text: Pt En Fr | PDF: Pt | PDF: En | PDF: Fr

Resumo A busca do engendramento de novas identidades culturais nas Américas se constitui, neste artigo, a partir de estudos centrados na análise de processos e mecanismos de representações literárias em contextos de turbulência sociopolítica e cultural. Nesse contexto, propõe-se uma abordagem de dois universos discursivos representativos de duas regiões culturais diferentes, observando a prática desconstrutora de matrizes colonialistas e a elaboração de uma discursividade crítica que torna evidentes semelhanças que os aproximam e diferenças que os identificam sob o processo do neocolonialismo contemporâneo na representação da figura do bastardo na obra do escritor canadense Réjean Ducharme La fille de Christophe Colomb (1969) e no texto de canções do disco Tropicália ou Panis et Circencis (1968) do compositor brasileiro Gilberto Gil.

Abstract The aim of this article is to search for the engendering of new cultural identities in the Americas, starting from studies centered on the analyses of processes and mechanisms of literary representations against backgrounds of sociopolitical and cultural turbulence. In this context, we propose an approach of two discursive universes representative of two different cultural regions, observing the deconstructive practice of colonialist matrices and the development of a critical discursivity that highlights the similarities that bring them closer and the differences that identify them under the process of contemporary neocolonialism in the representation of the character of the bastard in Canadian writer Réjean Ducharme’s novelThe Daughter of Christopher Columbus (La fille de Christophe Colomb[1969]) and in the song lyrics from the album Tropicália ou Panis et Circencis(1968), by Brazilian songwriter Gilberto Gil.

Résumé La quête de l’engendrement de nouvelles identités culturelles aux Amériques se constitue, dans cet article, à partir d’études centrées sur l’analyse de processus et de mécanismes de représentations littéraires dans des contextes de turbulence sociopolitique et culturelle. Dans ce contexte, il est proposé une approche de deux univers discursifs représentatifs de deux régions culturelles différentes, en observant la pratique déconstructive de matrices colonialistes et l’élaboration d’une discursivité critique qui met en évidence des ressemblances qui les approchent et des différences qui les identifient sous le processus du néocolonialisme contemporain dans la représentation de la figure du bâtard dans l'œuvre de l’écrivain canadien Réjean Ducharme La fille de Christophe Colomb (1969) et dans le texte de chansons de l’album Tropicália ou Panis et Circencis (1968) du compositeur brésilien Gilberto Gil.

https://doi.org/10.1590/1517-106x/2020222152171 399 downloads

Como plagiar sem perder a originalidade. O discurso dialógico de Bakhtin e o estatuto do bastardo - Em memória de Réjean Ducharme
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Vianna Neto, Arnaldo Rosa

Bakhtiniana: Revista de Estudos do Discurso

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mar 2019, Volume 14 N. 1 Pages 125 - 149

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Aborda-se neste artigo a condição suplementar de elaboração teórica do discurso literário no conceito multidimensional e interdisciplinar bakhtiniano, ou seja, a construção de um discurso relacional, ou uma poética da relação intertextual na obra do escritor quebequense Réjean Ducharme. Hifenizado como canadense-francês, confere-se a Ducharme o estatuto identitário do bastardo, ao qual se permite, ou se autoriza metaforicamente, a devoração e o plágio na prática de operações intertextuais como a citação, a paródia, a reciclagem e a bricolagem.

ABSTRACT This article discusses the additional condition of the theoretical elaboration of literary discourse in the Bakhtinian multidimensional and interdisciplinary concept, that is, the construction of a relational discourse, or a poetics of the intertextual relation in the work of the writer Réjean Ducharme. Hyphenated as Canadian-French, Ducharme is given the identity statute of bastard, and is allowed or metaphorically authorized to devour and plagiarize in the practice of intertextual operations, such as citation, parody, recycling, and patchwork.

https://doi.org/10.1590/2176-457334977 1662 downloads

Utilização de adoçantes no Brasil: uma abordagem a partir de um inquérito domiciliar
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Arrais, Paulo Sérgio Dourado

; Vianna, Marisa Perdigão de Negreiros

; Zaccolo, Anamaria Vargas

; Moreira, Luzia Izabel Mesquita

; Thé, Patrícia Maria Pontes

; Quidute, Ana Rosa Pinto

; Fontanella, Andréia Turmina

; Pizzol, Tatiane da Silva Dal

; Tavares, Noemia Urruth Leão

; Oliveira, Maria Auxiliadora

; Luiza, Vera Lucia

; Ramos, Luiz Roberto

; Farias, Mareni Rocha

; Bertoldi, Andréa Dâmaso

; Mengue, Sotero Serrate

Cadernos de Saúde Pública

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2019, Volume 35 N. 11 elocation e00010719

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O objetivo foi estimar a prevalência do uso de adoçantes pela população adulta brasileira e características dos usuários. Análise de dados da Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM, 2014), um inquérito nacional de base populacional. O desfecho de interesse foi o uso autorreferido de adoçantes entre brasileiros com 20 anos ou mais. As variáveis analisadas foram sexo, idade em anos completos, região do Brasil, escolaridade em anos completos e classificação econômica segundo o Critério Classificação Econômica Brasil da Associação Brasileira de Empresas de Pesquisa (ABEP). Os indicadores das condições de saúde foram: relato de doença crônica não transmissíveis (DCNT), número de DCNT e índice de massa corporal (IMC). A prevalência do uso de adoçantes na população adulta brasileira foi de 13,4% (IC95%: 12,5-14,3), sendo maior entre as pessoas do sexo feminino e no grupo com 60 anos ou mais, nas regiões Nordeste e Sudeste, entre pessoas da classe econômica A/B e entre indivíduos obesos. As pessoas com doenças crônicas (em especial diabetes) foram as que mostraram maior prevalência de uso de adoçantes, sendo o uso maior quanto maior o número de comorbidades relatadas. A prevalência de uso de adoçantes foi de 13,4% e mostrou-se associada a características sociodemográficas e de saúde.

Abstract: The objective was to estimate the prevalence of artificial sweetener use by the adult Brazilian population and users’ characteristics. Analysis of data from the Brazilian National Survey on Access, Utilization, and Promotion of Rational Use of Medicines (PNAUM, 2014), a nationwide population-based survey. The target outcome was self-reported use of sweeteners by Brazilians 20 years and older. The independent variables were sex, age, major geographic region of Brazil, schooling in complete years, and economic status according to the Brazilian Economic Classification Criterion of the Brazilian Association of Research Companies (ABEP). The health condition indicators were: self-reported noncommunicable diseases (NCDs), number of NCDs, and body mass index (BMI). Prevalence of sweetener use in the Brazilian adult population was 13.4% (95%CI: 12.5-14.3), and it was higher in females and in persons 60 years or older, in the Northeast and Southeast, among individuals from economic classes A and B, and among obese individuals. Persons with chronic diseases (especially diabetes) showed the highest prevalence of use of sweeteners, and their use increased with the number of reported comorbidities. Prevalence of use of artificial sweeteners was 13.4% and was associated with sociodemographic and health characteristics.

Resumen: El objetivo fue estimar la prevalencia del uso de edulcorantes por parte de la población adulta brasileña y las características de los usuarios. Análisis de datos de la Encuesta Nacional de Acceso, Utilización y Promoción del Uso Racional de Medicamentos (PNAUM, 2014), una encuesta nacional de base poblacional. El resultado de interés fue el uso autoinformado de edulcorantes entre brasileños con 20 años o más. Las variables analizadas fueron: sexo, edad (años completados), región de Brasil, escolaridad (años completados), así como la clasificación económica según el Criterio Clasificación Económica Brasil de la Asociación Brasileña de Empresas de Investigación (ABEP). Los indicadores de las condiciones de salud fueron: informe de enfermedades crónicas (DCNT), número de DCNT e índice de masa corporal (IMC). La prevalencia del uso de edulcorantes en la población adulta brasileña fue de un 13,4% (IC95%: 12,5-14,3), siendo mayor entre las personas de sexo femenino y en el grupo con 60 años o más, en las regiones Nordeste y Sudeste, entre personas de clase económica A/B y entre individuos obesos. Las personas con enfermedades crónicas (en especial diabetes) fueron las que mostraron una mayor prevalencia de uso de edulcorantes, siendo el uso mayor, cuanto mayor fuera el número de comorbilidades informadas. Conclusiones: la prevalencia de uso de edulcorantes fue de un 13,4% y se mostró asociada a características sociodemográficas y de salud.

https://doi.org/10.1590/0102-311x00010719

Utilização de adoçantes no Brasil: uma abordagem a partir de um inquérito domiciliar
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Arrais, Paulo Sérgio Dourado

; Vianna, Marisa Perdigão de Negreiros

; Zaccolo, Anamaria Vargas

; Moreira, Luzia Izabel Mesquita

; Thé, Patrícia Maria Pontes

; Quidute, Ana Rosa Pinto

; Fontanella, Andréia Turmina

; Pizzol, Tatiane da Silva Dal

; Tavares, Noemia Urruth Leão

; Oliveira, Maria Auxiliadora

; Luiza, Vera Lucia

; Ramos, Luiz Roberto

; Farias, Mareni Rocha

; Bertoldi, Andréa Dâmaso

; Mengue, Sotero Serrate

Cadernos de Saúde Pública

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2019, Volume 35 N. 11 elocation e00010719

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00010719 1579 downloads

10.

From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America
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Schüler-Faccini, Lavinia

; Sanseverino, Maria Teresa Vieira

; Abeche, Alberto Mantovani

; Vianna, Fernanda Sales Luiz

; Fraga, Lucas Rosa

; Rocha, Anastacia Guimaraes

; Silva, André Anjos da

; Souza, Paulo Ricardo Assis de

; Hilgert, Artur Hartmann

; Barbosa, Camila Pocharski

; Kauppinem, Caroline Grasso

; Martins, Daniela Fernandes

; Santos, Daniela Silva

; Colpes, Gabriel Henrique

; Ecco, Gabriela

; Silva, Helena Margot Flores Soares da

; Penteado, Louise Piva

; Santos, Tatiane dos

Genetics and Molecular Biology

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2019, Volume 42 N. 1 Pages 297 - 304

Abstract: En | Text: En | PDF: En

Abstract In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT is a free-to-use information service both to health professionals and the general population, especially to women who are pregnant or planning pregnancy. The main objective of this paper is to present the activities of SIAT in its initial years (1990-2006), compared to those in the last decade (2007-2017). In addition we review the scientific contribution of SIAT in the field of human teratogenesis. Since 1990, SIAT received 10,533 calls. Use of medications were the main reason for concern, accounting for 74% of all questions, followed by other chemical exposures (occupational, cosmetics, environmental), and maternal infectious diseases. Among its main contributions to scientific knowledge was the collaboration for the identification of two new human teratogens: misoprostol in the 1990s and Zika virus in 2015/16. In conclusion, SIAT is still evolving, as is the Medical Genetics Service that hosts it. Through its 27 years of existence more than 300 undergraduate and graduate students have rotated at SIAT. Presently, SIAT is expanding the research to experimental teratogenesis and to investigation of molecular mechanisms of teratogens.

https://doi.org/10.1590/1678-4685-gmb-2018-0111 1024 downloads

11.

Morpho-agronomic characterization and analysis of genetic divergenceamong accessions of tomatoes (Solanum lycopersicum L.)
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Fernandes, Murilo de Oliveira

; Bianchi, Paola Alvares

; Silva, Lígia Renata Almeida da

; Vianna, Larissa Souza

; Santos, Eileen Azevedo

; Moulin, Monique Moreira

Ciência Rural

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2018, Volume 48 N. 11 elocation 20180433

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A coleta e caracterização do germoplasma de tomate são de relevante importância para a agricultura. O presente trabalho objetivou coletar e caracterizar, por intermédio de descritores morfoagronômicos e ferramentas estatísticas, os acessos de tomate das regiões Sul e Serrana do Estado do Espírito Santo, bem como constituir o banco de germoplasma de tomate do Ifes, Campus de Alegre. Foram coletados 37 acessos de tomate em diferentes pontos comerciais do Espírito Santo. O experimento foi conduzido no Setor de Olericultura do Ifes Campus de Alegre. Para a caracterização morfoagronômica, foram utilizados 16 descritores essenciais, 9 quantitativos e 7 qualitativos. Para a característica cor do fruto maduro, houve a formação de cinco distintos grupos com as cores amarelo, verde, laranja, rosa e vermelha. No formato do fruto, houve formação de três grupos, ligeiramente achatado, achatado e arredondados. A ANOVA mostrou que houve diferença significativa para todas as características quantitativas avaliadas. Pelo procedimento Ward-MLM, devido a elevada função de verossimilhança no grupo sete (de 130.71), foi possível agrupar os 37 genótipos em sete grupos. A maior dissimilaridade foi observada nos grupos V e VII com distância de 330.02, e os menos dissimilares, os grupos IV e VI, com 8.21. Detectou-se variabilidade genética no germoplasma de tomate para as características morfo-agronômicas. Muitos dos acessos são promissoras fontes de fenótipos de interesse para o banco de germoplasma do Ifes.

ABSTRACT: The collection and characterization of tomato germplasm are of relevant importance for agriculture. This study aimed to collect and characterize, by way of morphological description and statistical tools for the composition of groups, tomato accesses from the Southern and Serrana regions of the State of Espírito Santo, as well as to establish the tomato germplasm bank of the Ifes - Campus de Alegre. Thirty-seven accessions were collected from different commercial locations of Espírito Santo. The experiment was conducted in the Ifes Campus de Alegre in the Agroecology sector. For the morpho-agronomic characterization, sixteen essential descriptors were used, nine quantitative and seven qualitative. In the color of the ripe fruit, there was the formation of five distinct groups with the colors yellow, green, orange, pink and red. In the format of the fruit, three groups were formed, slightly flattened, flattened and rounded. The ANOVA showed that there was a significant difference for all the quantitative characteristics evaluated. According to the Ward-MLM procedure, due to the high likelihood function in group seven (from 130.71), it was possible to group the 37 genotypes into seven groups. The greatest dissimilarity was observed in groups V and VII with a distance of 330.02, and the least dissimilar ones, groups IV and VI, with 8.21. Genetic variability was detected in tomato germplasm for the morpho-agronomic characteristics. Many of the accessions are promising sources of phenotypes of interest to the Ifes germplasm bank.

https://doi.org/10.1590/0103-8478cr20180433 1935 downloads

12.

PROJETO DE GESTÃO INTEGRADA DA ORLA MARÍTIMA. A EXPERIÊNCIA DO MUNICÍPIO DE CAMPOS DOS GOYTACAZES, RIO DE JANEIRO, BRASIL
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Bulhoes, Eduardo Manuel Rosa

; Klotz, Stéphanie Katrin Vianna

; Mota, Izaura da Silva Arêas

; Tavares, Tatiane Cardoso

; Sanguêdo, Juliana Bastos

; Cidade, Carolina Almeida Santos

Sociedade & Natureza

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aug 2016, Volume 28 N. 2 Pages 285 - 300

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Em Campos dos Goytacazes-RJ, o Projeto Orla vem sendo articulado envolvendo as três esferas de poder e a representação da sociedade civil. Iniciou em dezembro de 2009 objetivando promover a gestão sustentável da orla e assegurar a preservação ambiental e o ordenamento da orla denominada Farol de São Thomé. O objetivo geral do artigo é registrar o processo de implantação do projeto, expondo etapas cumpridas, participação dos atores, questões de interesse e resultados alcançados. A municipalidade é responsável pela adesão e, com a sociedade civil, pela ação mais direta do projeto. Atuam nas etapas de diagnóstico, subdivisão em unidades de paisagens e trechos, levantamentos de usos, identificação de problemas e elaboração de cenários desejados. Os conflitos pelo uso das áreas naturais esbarram nas atividades já consolidadas e identificadas como geradoras de problemas como o comércio, a pesca, turismo e construção civil. O PGI (Plano de Gestão Integrada) foi consolidado e submetido à avaliação da instrutora do Projeto Orla que, em março de 2014, atestou sua adequação à metodologia específica. Em seguida, foi encaminhado às coordenações técnica nacional e estadual que emitiram parecer favorável com suas considerações, recomendações e sugestões de adequação, em dezembro de 2014. O PGI e o Comitê Gestor foram finalmente homologados em audiência pública no dia 16 de maio de 2015. Destaca-se que foi a primeira homologação no estado do Rio de Janeiro. No momento atual ocorrem as reuniões iniciais do Comitê Gestor e as pautas que visam consolidar as ações programadas para a orla do município.

ABSTRACT: In Campos dos Goytacazes municipality, the articulation of Orla Project involves the three branches of power and the representation of civil society. It started in December 2009 aiming to promote the sustainable management of the waterfront and ensure environmental preservation and coastal planning. The overall objective of this paper is to register the project implementation process, exposing met steps, stakeholder participation, issues of interest and results. The municipality is responsible for membership, and with civil society, by the most direct action in project. They work in diagnostic steps, subdivision into landscape units and stretches, uses surveys, problem identification and preparation of desired scenarios. The conflicts over the use of natural areas come up against the already established activities and identified as generating issues such as trade, fisheries, tourism and civil construction. The PGI (Integrated Management Plan) was consolidated and submitted to the assessment of instructor of the Orla Project, in March 2014, who attested its adaptation to the specific methodology. Then it was sent to national and state technical coordination, which issued a favourable opinion with his remarks, recommendations and suggestions adequacy in December 2014. The PGI and the Steering Committee were finally approved in open court on 16 May 2015. It is noteworthy that it was the first approval in the state of Rio de Janeiro. Now occur the initial meetings of the Steering Committee and the guidelines that aim to consolidate the actions scheduled for the council's edge.

https://doi.org/10.1590/1982-451320160208 2282 downloads

13.

Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome
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Fröhlich, Alan Christmann

; Eckeli, Alan Luiz

; Bacelar, Andrea

; Poyares, Dalva

; Pachito, Daniela Vianna

; Stelzer, Fernando Gustavo

; Coelho, Fernando Morgadinho Santos

; Rizzo, Geraldo Nunes Vieira

; Prado, Gilmar Fernandes do

; Sander, Heidi Haueisen

; Goulart, Leonardo Ierardi

; Lucchesi, Ligia Mendonça

; Gitai, Lívia Leite Góes

; Prado, Lucila Bizari Fernandes do

; Ataíde-Junior, Luiz

; Bezerra, Marcio Luciano de Souza

; Lopes, Maria Cecília

; Trentin, Marine Meliksetyan

; Rodrigues, Raimundo Nonato Delgado

; Hasan, Rosa

; Alves, Rosana S. Cardoso

; Schönwald, Suzana Veiga

; Moraes, Walter André dos Santos

Arquivos de Neuro-Psiquiatria

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mar 2015, Volume 73 N. 3 Pages 260 - 280

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O Consenso em síndrome das pernas inquietas contou com a participação de neurologistas de vários estados brasileiros, os quais incansavelmente revisaram a literatura dos últimos anos em busca de evidências, tanto no que se refere ao diagnóstico como ao tratamento, de acordo com a Classificação do Centro de Oxford para Medicina Baseada em Evidências.

The Consensus on restless legs syndrome is an effort of neurologists from several Brazilian states, which tirelessly reviewed the literature of recent years in search of evidence, both in regard to diagnosis and treatment, according to the Oxford Centre for Evidence-based Medicine.

https://doi.org/10.1590/0004-282X20140239 7813 downloads

14.

Access to and utilization of prenatal care services in the Unified Health System of the city of Rio de Janeiro, Brazil
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Domingues, Rosa Maria Soares Madeira

; Leal, Maria do Carmo

; Hartz, Zulmira Maria de Araujo

; Dias, Marcos Augusto Bastos

; Vettore, Marcelo Vianna

Revista Brasileira de Epidemiologia

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dec 2013, Volume 16 N. 4 Pages 953 - 965

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A assistência pré-natal é composta por práticas consideradas efetivas para a redução de desfechos perinatais negativos. Entretanto, estudos têm demonstrado iniquidades no acesso das gestantes aos cuidados pré-natais, com piores resultados para mulheres de menor nível socioeconômico. O objetivo deste estudo é avaliar o acesso e a utilização dos serviços de pré-natal na rede do Sistema Único de Saúde (SUS) do Município do Rio de Janeiro e verificar sua associação a características das gestantes e dos serviços de saúde. Foi realizado um estudo transversal, no período 2007 - 2008, por meio de entrevista e análise de cartões de pré-natal de 2.353 gestantes em atendimento em serviços de pré-natal de baixo risco do SUS. Foi feita análise descritiva das razões referidas pelas mulheres para início tardio do pré-natal e regressão logística hierarquizada para identificação dos fatores associados à utilização do pré-natal. A ausência de diagnóstico da gravidez e dificuldades de acesso aos serviços foram as razões mais relatadas para o início tardio do pré-natal. Verificou-se acesso mais precoce de gestantes de cor branca, com maior escolaridade, primigestas e com companheiro. O início tardio foi o fator mais associado ao número inadequado de consultas, também verificado em gestantes adolescentes. Mulheres de cor preta apresentaram menor adequação na realização de exames, bem como menor adequação global do pré-natal, segundo parâmetros do Programa de Humanização do Pré-natal e Nascimento (PHPN). Estratégias para identificação de gestantes de maior risco reprodutivo, redução de barreiras organizacionais nos serviços e ampliação do acesso ao planejamento familiar e ao diagnóstico precoce da gravidez são prioritárias.

Prenatal care consists of practices considered to be effective for the reduction of adverse perinatal outcomes. However, studies have demonstrated inequities in pregnant women's access to prenatal care, with worse outcomes among those with lower socioeconomic status. The objective of this study is to evaluate access to and utilization of prenatal services in the Sistema Único de Saúde (SUS - Unified Health System) in the city of Rio de Janeiro and to verify its association with the characteristics of pregnant women and health services. A cross-sectional study was conducted in 2007-2008, using interviews and the analysis of prenatal care cards of 2.353 pregnant women attending low risk prenatal care services of the SUS. A descriptive analysis of the reasons mentioned by women for the late start of prenatal care and hierarchical logistic regression for the identification of the factors associated with prenatal care use were performed. The absence of a diagnosis of pregnancy and poor access to services were the reasons most often reported for the late start of prenatal care. Earlier access was found among white pregnant women, who had a higher level of education, were primiparous and lived with a partner. The late start of prenatal care was the factor most associated with the inadequate number of consultations, also observed in pregnant adolescents. Black women had a lower level of adequacy of tests performed as well as a lower overall adequacy of prenatal care, considering the Programa de Humanização do Pré-Natal e Nascimento (PHPN - Prenatal and Delivery Humanization Program) recommendations. Strategies for the identification of pregnant women at a higher reproductive risk, reduction in organizational barriers to services and increase in access to family planning and early diagnosis of pregnancy should be prioritized.

https://doi.org/10.1590/S1415-790X2013000400015 1971 downloads

15.

Access to and utilization of prenatal care services in the Unified Health System of the city of Rio de Janeiro, Brazil
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Domingues, Rosa Maria Soares Madeira

; Leal, Maria do Carmo

; Hartz, Zulmira Maria de Araújo

; Dias, Marcos Augusto Bastos

; Vettore, Marcelo Vianna

Revista Brasileira de Epidemiologia

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dec 2013, Volume 16 N. 4 Pages 953 - 965

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/S1415-790X2013000400015 6386 downloads

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