Search | SciELO

Abstract Background: Only a fraction of patients with cutaneous lupus erythematosus (CLE) will eventually progress toward systemic disease (SLE). Objective: To find inflammatory biomarkers which could predict the progression of cutaneous lupus erythematosus (CLE) into systemic lupus erythematosus (SLE) using immunohistochemical (IHC) assays. Methods: Immunohistochemical markers for cytotoxic, inflammatory, and anti-inflammatory responses and morphometric methods were applied to routine paraffin sections of skin biopsies, taken from lesions of 59 patients with discoid lupus, subacute lupus, and lupus tumidus. For the diagnosis of SLE, patients were classified by both the American College of Rheumatology (ACR-82) and the Systemic Lupus International Collaborating Clinics (SLICC-12) systems. Results: Skin samples from CLE/SLE +patients presented higher expression of IL-1β (ARC-82: p = 0.024; SLICC-12: p = 0.0143) and a significantly higher number of cells marked with granzyme B and perforin (ARC: p = 0.0097; SLICC-12: p = 0.0148). Biopsies from CLE/SLE- individuals had higher expression of IL-17 (ARC-82: p = 0.0003; SLICC-12: p = 0.0351) and presented a positive correlation between the density of granzyme A+and FoxP3+ cells (ARC-82: p = 0.0257; SLICC-12: p = 0.0285) and CD8+ cells (ARC-82: p = 0.0075; SLICC-12: p = 0.0102), as well as between granulysin-positive and CD8+ cells (ARC-82: p = 0.0024; SLICC-12: p = 0.0116). Study limitations: Patients were evaluated at a specific point in their evolution and according to the presence or not of systemic disease. The authors cannot predict how many more, from each group, would have evolved towards SLE in the following years. Conclusions: In this cohort, immunohistochemical findings suggested that patients with a tendency to systemic disease will show strong reactivity for IL-1β, while those with purely cutaneous involvement will tend to express IL-17 more intensely.

https://doi.org/10.1016/j.abd.2023.02.007

F-waves persistence in peripheral sensory syndromes
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Lima, Fabricio Diniz de

; Martinez, Alberto Rolim Muro

; Schmitt, Gabriel da Silva

; França, Andrea Fernandes Eloy da Costa

; Velho, Paulo Eduardo Neves Ferreira

; Akita, Juliana

; Garbino, José Antônio

; Nucci, Anamarli

; França Jr, Marcondes Cavalcante

Arquivos de Neuro-Psiquiatria

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2023, Volume 81 N. 9 Pages 785 - 794

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background The distinction between sensory neuronopathies (SN), which is by definition purely sensory, and sensory polyneuropathies (SP) and sensory multineuropathies (SM) is important for etiologic investigation and prognosis estimation. However, this task is often challenging in clinical practice. We hypothesize that F-wave assessment might be helpful, since it is able to detect subtle signs of motor involvement, which are found in SP and SM, but not in SN. Objective The aim of the present study was to determine whether F-waves are useful to distinguish SN from SP and SM. Methods We selected 21 patients with SP (12 diabetes mellitus, 4 transthyretin familial amyloid polyneuropathy, 4 others), 22 with SM (22 leprosy), and 26 with SN (13 immune-mediated, 10 idiopathic, 3 others) according to clinical-electrophysiological-etiological criteria. For every subject, we collected data on height and performed 20 supramaximal distal stimuli in median, ulnar, peroneal, and tibial nerves, bilaterally, to record F-waves. Latencies (minimum and mean) and persistences were compared across groups using the Kruskal-Wallis and Bonferroni tests. P-values < 0.05 were considered significant. Results All groups were age, gender, and height-matched. Overall, there were no significant between-group differences regarding F-wave latencies. In contrast, F-wave persistence was able to stratify the groups. Peroneal F-wave persistence was higher, bilaterally, in the SN group compared to SM and SP (p < 0.05). In addition, F-waves persistence of the ulnar and tibial nerves was also helpful to separate SN from SP (p < 0.05). Conclusion F-wave persistence of the peroneal nerves might be an additional and useful diagnostic tool to differentiate peripheral sensory syndromes.

Resumo Antecedentes A distinção entre neuronopatias sensitivas (SN) e polineuropatias sensitivas (SP) e multineuropatias sensitivas (SM) é importante para a investigação etiológica e para o prognóstico. Contudo, esta tarefa é desafiadora na prática clínica. Hipotetizou-se que a avaliação das ondas-F pode ser útil, por ser capaz de detectar envolvimento motor nas SP e SM, mas não nas SN. Objetivo Determinar se as ondas-F podem ajudar a distinguir entre SN, SP e SM. Métodos Selecionou-se 21 pacientes com SP (12 diabetes mellitus, 4 ATTR-FAP e 4 com outras neuropatias), 22 com SM (22 hanseníases) e 26 com SN (13 imunomediadas, 10 idiopáticas e 3 com outras neuronopatias), de acordo com critérios clínicos, etiológicos e eletrofisiológicos. Para cada indivíduo, foi aferida a altura e foram aplicados 20 estímulos distais supramáximos nos nervos mediano, ulnar, fibular e tibial, bilateralmente, para registrar as ondas-F. Uma comparação foi feita, por grupo, das latências (mínimas e médias) e persistências pelos testes Kruskal-Wallis e Bonferroni. Valores de p < 0.05 foram considerados estatisticamente significativos. Resultados Todos os grupos foram pareados por idade, sexo e altura. Não houve diferença estatística significativa entre os grupos quanto às latências das ondas-F. A persistência da onda-F foi capaz de estratificar os grupos, sendo as dos nervos fibulares bilateralmente maiores no grupo SN que nos grupos SM e SP (p < 0.05). Adicionalmente, a persistência das ondas-F dos nervos ulnares e tibiais também foi útil para distinguir SN de SP (p < 0.05). Conclusão A persistência das ondas-F dos nervos fibulares pode ser uma ferramenta adicional e útil para diferenciar síndromes sensitivas periféricas.

https://doi.org/10.1055/s-0043-1772599

Detection of Bartonella henselae DNA in the blood of patients with livedoid vasculopathy
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Drummond, Marina Rovani

; Santos, Luciene Silva dos

; Souza, Lais Bomediano

; Mitsuushi, Gabriela Nero

; Cintra, Maria Letícia

; França, Andrea Fernandes Eloy da Costa

; Souza, Elemir Macedo de

; Velho, Paulo Eduardo Neves Ferreira

Anais Brasileiros de Dermatologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2023, Volume 98 N. 4 Pages 472 - 479

Abstract: En | Text: En | PDF: En

Abstract Background: Livedoid vasculopathy (LV) manifests as ulcers and atrophic white scars on the lower extremities. The main known etiopathogenesis is hypercoagulability with thrombus formation, followed by inflammation. Thrombophilia, collagen and myeloproliferative diseases may induce LV, but the idiopathic (primary) form predominates. Bartonella spp. may cause intra-endothelial infection and skin manifestations caused by these bacteria may be diverse, including leukocytoclastic vasculitis and ulcers. Objective: The aim of this study was to investigate the presence of bacteremia by Bartonella spp. in patients with difficult-to-control chronic ulcers diagnosed as primary LV. Methods: Questionnaires and molecular tests (conventional PCR, nested PCR and real-time PCR) were applied and liquid and solid cultures were performed in the blood samples and blood clot of 16 LV patients and 32 healthy volunteers. Results: Bartonella henselae DNA was detected in 25% of LV patients and in 12.5% of control subjects but failed to reach statistically significant differences (p = 0.413). Study limitations: Due to the rarity of primary LV, the number of patients studied was small and there was greater exposure of the control group to risk factors for Bartonella spp. infection. Conclusion: Although there was no statistically significant difference between the groups, the DNA of B. henselae was detected in one of every four patients, which reinforces the need to investigate Bartonella spp. in patients with primary LV.

https://doi.org/10.1016/j.abd.2022.07.007

Bartonella henselae as a putative trigger for chronic type 2 leprosy reactions
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Luciene Silva dos

; Drummond, Marina Rovani

; Goulart, Isabela Maria Bernardes

; França, Andrea Fernandes Eloy da Costa

; Souza, Elemir Macedo de

; Velho, Paulo Eduardo Neves Ferreira

Brazilian Journal of Infectious Diseases

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2023, Volume 27 N. 6 elocation 103701

Abstract: En | Text: En | PDF: En

Abstract Leprosy reactions are an acute inflammatory phenomenon that can arise before diagnosis, during treatment, or after cure of leprosy. These reactions are considered one of the main diseases that cause physical disabilities. Immunosuppressive treatment for these immune responses makes these patients susceptible to coinfections, which can trigger new leprosy reactions. The main objective of this study was to evaluate the occurrence of infection by Bartonella sp. in blood samples from 47 patients who had untreatable episodes of type 2 leprosy reactions for more than six months, comparing them with a control group. Cultures and molecular methods (PCR) were used. Amplicons from species-specific reactions and sequencing showed a higher prevalence of Bartonella henselae infection in patients, 19/47 (40.4 %), compared to control, 9/50 (18.0 %), p= 0.0149. Five patients accepted treatment for coinfection, and all showed improvement in leprosy reactions with treatment for B. henselae infection. We conclude that these bacteria can trigger chronic reactions of type 2 leprosy and should be investigated in these patients. Summary line Patients who have chronic type 2 leprosy reactions are more susceptible to Bartonella henselae infection than controls: 19/47 (40.4 %) compared 9/50 (18.0 %), p= 0.0149.

https://doi.org/10.1016/j.bjid.2023.103701

The knowledge of memory aging questionnaire (KMAQ) in a Brazilian sample: a questionnaire for informants to recognize early signs of dementia
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Montiel-Aponte, Mariel Carolina

; Bertolucci, Paulo Henrique Ferreira

; Rocha, Gustavo Gil Velho

Dementia & Neuropsychologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2023, Volume 17 elocation e20220090

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT. Till present, only a few countries have developed support programs for caregivers and families of patients with dementia aimed to improve knowledge, skills, and strategies to deal with the patient's symptoms. However, prior to offering this special support, it is important to identify beliefs and thoughts shared by informants related to cognition in elderly people. Questionnaires are instruments that allow having this information, such as the Knowledge of Memory Aging Questionnaire (KMAQ), which was designed to assess normal and pathological changes in the aging process. Objective: The aim of this study was to assess the knowledge about cognition, aging, and dementia as evaluated by the KMAQ in people who are in contact with elderly people, with and without cognitive impairment. Methods: A total of 78 relatives and caregivers of elderly patients were classified into two groups: group 1: relatives of patients with dementia (n1=48), and group 2: relatives of patients without cognitive impairment (n2=30). They were asked to answer some questionnaires about dementia, including the KMAQ. Results: Comparing the questionnaire's scores for normal cognitive changes items (g1: 0.53 vs. g2: 0.53, p-value: 0.99) did not show differences between the knowledge in both groups, nor shows the scores for pathological cognitive changes items (g1: 0.55 vs. g2: 0.55, p-value: 0.969). Conclusions: It seems that being in contact with dementia does not improve knowledge about it. Knowledge of normal changes in cognition could make it possible to recognize “red flags” suggestive of neurodegenerative processes, allowing for earlier diagnosis and more options for treatment.

RESUMO. Até o presente momento, poucos países desenvolveram programas destinados a cuidadores e familiares de pacientes com demência, objetivando o aprimoramento de conhecimentos, habilidades e estratégias para lidar com os sintomas dos pacientes. Entretanto, antes de prestar esse suporte especial, faz-se importante identificar crenças e pensamentos compartilhados por informantes acerca da cognição em pessoas idosas. Os questionários são instrumentos que permitem obter essa informação, a exemplo do Questionário de Conhecimento de Memória e Envelhecimento (KMAQ, sigla em inglês), que foi elaborado para avaliar mudanças normais e patológicas no processo de envelhecimento. Objetivo: O objetivo deste estudo foi avaliar o conhecimento sobre cognição, envelhecimento e demência pela aplicação do KMAQ em pessoas que estão em contato com pessoas idosas com e sem comprometimento cognitivo. Métodos: Setenta e oito familiares e cuidadores de pacientes idosos foram divididos em dois grupos: grupo 1 — parentes de pacientes com demência (n1=48); e grupo 2 — parentes de pessoas sem comprometimento cognitivo (n2=30). Foi-lhes solicitado responder a questionários sobre demência, incluindo o KMAQ. Resultados: Quando analisadas as pontuações do questionário para os itens de mudanças normais no envelhecimento (g1: 0,53 vs. g2: 0,53, valor p: 0,99) não tivemos diferenças significativas no conhecimento entre os dois grupos, não havendo diferenças na pontuação para os itens de mudanças patológicas no envelhecimento (g1: 0,55 vs. g2: 0,55, valor p: 0,969). Conclusões: Estar em contato com a demência não parece melhorar o conhecimento sobre essa síndrome. Conhecer as mudanças normais na cognição durante o envelhecimento permite identificar “sinais de alarme” sugestivos de processos degenerativos, alcançando-se um diagnóstico precoce e mais opções para o tratamento.

https://doi.org/10.1590/1980-5764-dn-2022-0090

Políticas públicas e mobilidade urbana sustentável: análise comparativa entre Groningen e Campinas
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Rodrigues, Livia Ferreira Velho

; Maia, Alexandre Gori

; Carvalho, Cristiane Silva de

Cadernos Metrópole

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2022, Volume 24 N. 55 Pages 1143 - 1161

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A Política Nacional de Mobilidade Urbana motiva os municípios brasileiros a desenvolver uma série de ações a favor dos transportes públicos coletivos e não motorizados, mas ainda são escassos os casos bem-sucedidos de promoção de transporte urbano sustentável no Brasil. Este artigo analisa a experiência de Campinas na promoção do transporte cicloviário, que é comparada com um caso de sucesso no mundo, Groningen (Holanda). As análises baseiam-se em entrevistas realizadas com gestores públicos e especialistas nas duas cidades em estudo. Os resultados mostram fatores institucionais essenciais para o sucesso ou fracasso da política de mobilidade cicloviária. Destaca-se, particularmente, que ações de desestímulo ao uso do veículo privado são tão importantes quanto as de promoção do uso de bicicletas.

Abstract The National Urban Mobility Policy encourages Brazilian cities to develop a series of actions in favor of public and non-motorized transport, but successful cases of promotion of sustainable urban transport are still scarce in Brazil. This article analyzes the experience of Campinas concerning promotion of bicycle transportation, comparing it with a successful international case, namely, the city of Groningen (the Netherlands). The analyses are based on interviews with public managers and specialists in the two assessed cities. The results show fundamental institutional factors for the success or failure of the cycling policy. It is particularly noteworthy that actions to discourage the use of private vehicles are as important as those to promote the use of bicycles.

https://doi.org/10.1590/2236-9996.2022-5513

Two-year history of lymphadenopathy and fever caused by Bartonella henselae in a child
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Maria, Helga Kaiser Sanches de

; Gazzoli, Emily

; Drummond, Marina Rovani

; Almeida, Amanda Roberta de

; Santos, Luciene Silva dos

; Pereira, Ricardo Mendes

; Tresoldi, Antonia Terezinha

; Velho, Paulo Eduardo Neves Ferreira

Revista do Instituto de Medicina Tropical de São Paulo

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, Volume 64 elocation e15

Abstract: En | Text: En | PDF: En

ABSTRACT We report the case of a 6-year-old boy that presented with enlarged lymph nodes on his neck. He complained of tiredness and discouragement, which worsened during feverish periods. There were no relevant laboratory test abnormalities and serological tests were not reactive. Bartonella henselae DNA was detected by species-specific nested polymerase chain reaction. After treatment, the patient progressed with no fever or lymphadenopathy. Bartonellosis is a group of infectious diseases caused by bacteria of the genus Bartonella. This case report is a useful reminder to clinicians that long-term fever of unknown origin can be related to B. henselae infection, even if the specific serology is not reactive.

https://doi.org/10.1590/s1678-9946202264015

Chronic type 2 reaction possibly triggered by an asymptomatic Bartonella henselae infection in a leprosy patient
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Luciene Silva dos

; Drummond, Marina Rovani

; França, Andrea Fernandes Eloy da Costa

; Pavan, Maria Helena Postal

; Stelini, Rafael Fantelli

; Cintra, Maria Letícia

; Souza, Elemir Macedo de

; Velho, Paulo Eduardo Neves Ferreira

Revista do Instituto de Medicina Tropical de São Paulo

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, Volume 64 elocation e17

Abstract: En | Text: En | PDF: En

ABSTRACT As leprosy and leprosy reactions are the most prevalent infectious cause of physical disability, it is important to commit efforts to better understand these chronic reactions. Infections, even when asymptomatic, can trigger leprosy reactions and Bartonella spp. in turn, can cause chronic infections. We presented a case of a 51-year-old man who was admitted presenting with chronic type 2 leprosy reactions. He had a lepromatous form of leprosy that was histologically diagnosed six months after the onset of signs and symptoms compatible with a chronic type 2 reaction. He reported a history of a previous hepatitis B diagnosis. During a 24-month multidrug therapy (MDT), chronic reactions were partially controlled with prednisone and thalidomide. Thirty-three months following the leprosy treatment, he still experienced chronic reactions, and whole bacilli as well as globi were found on a new skin biopsy. Since coinfections can trigger type 2 reactions and the patient had close contact with animals and ticks, we investigated the presence of a Bartonella sp. infection. Bartonella henselae DNA was detected in a skin fragment obtained before the beginning of the leprosy retreatment. However, even after six months of a second leprosy MDT, he continued to experience type 2 chronic reactions. He was admitted to the hospital to undergo an intravenous antibiotic therapy for 14 days and then complete the treatment per os for ten more weeks. Leprosy reactions improved following the treatment for B. henselae. After completing the MDT treatment, he has been accompanied for sixty months with no signs of leprosy or leprosy reactions. The asymptomatic infection by B. henselaein this patient was considered the putative trigger of chronic leprosy reactions and leprosy relapse.

https://doi.org/10.1590/s1678-9946202264017

Potencial agronômico de linhagens de feijão para qualidade de sementes e rendimento de grãos
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Cerutti*, Paulo Henrique

; Carbonari, Luan Tiago do Santos

; Benato, Felipe Reck

; Schwarzer, Pedro Antonio

; Velho, Henrique Scopel

; Nascimento, Marieli do

; Souza, Larisa Sandri de

Revista de Ciências Agrárias

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2021, Volume 44 N. 4 Pages 41 - 50

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract A large portion of the bean production in Brazil is carried out by family farmers, who perform the rescue of seeds on their properties. Thus, the objective was to investigate the behavior of bean lines maintained by farmers, considering seed quality and grain yield characteristics. Two tests were performed. One in biochemical oxygen demand (BOD) and other in field. Ten treatments were evaluated, formed by eight beans lines and two commercial cultivars. In a controlled environment, a completely randomized design was used, and randomized complete block design for the field. The variables evaluated were germination percentage (GER), radicle length (CPR), stem diameter (DC), thousand grain mass (MMG) and grain yield (REND). Analysis of variance and comparisons of means were performed. The variation analysis indicated significance of the treatments for variables. Significance reflects the presence of variability between lines. Through comparisons of means, it was possible to observe which lines promote increases in the phenotypic mean. The lines differed from the controls for the variables MMG, DC and GER. Thus, two lines maintained by farmers have an agronomic potential similar to commercial cultivars, and thus are alternatives for cultivation in local agriculture.

Resumo Grande parcela da produção de feijão no Brasil é realizada por agricultores familiares que executam o resgate de sementes em suas propriedades. Desse modo, objetivou-se averiguar o comportamento de linhagens de feijão mantidas por agricultores, considerando as características de qualidade de sementes e rendimento de grãos. Assim, foram executados dois ensaios. Um em demanda bioquímica de oxigênio (BOD) e outro a campo. Foram avaliados dez tratamentos, formados por oito linhagens de feijão e duas cultivares comerciais. Em ambiente controlado foi utilizado o delineamento inteiramente casualizado e para o campo o de blocos completos casualizados. As variáveis avaliadas foram: percentual de germinação (GER), comprimento de radícula (CPR), diâmetro de caule (DC), massa de mil grãos (MMG) e rendimento de grãos (REND). Foi realizada a análise de variância e comparações de médias. A análise da variação indicou significância das linhagens para as variáveis. A significância reflete a presença de variabilidade entre as linhagens consideradas. Por meio de comparações de médias, foi possível observar quais linhagens promovem incrementos na média fenotípica. A linhagens diferiram das testemunhas para as variáveis MMG, DC e GER. Desse modo, duas linhagens mantidas por agricultores apresentam potencial agronômico semelhante as cultivares comerciais, e assim são alternativas de cultivo na agricultura local.

https://doi.org/10.19084/rca.24613 2 downloads

10.

Body Composition Influences Post-Operative Complications and 90-Day and Overall Survival in Pancreatic Surgery Patients
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Velho, Sónia

; Santos, Maria Pia Costa

; Cunha, Cátia

; Agostinho, Lisa

; Cruz, Rita

; Costa, Filipe

; Garcia, Mafalda

; Oliveira, Paulo

; Maio, Rui

; Baracos, Vickie E.

; Cravo, Marília

GE-Portuguese Journal of Gastroenterology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

feb 2021, Volume 28 N. 1 Pages 13 - 25

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Introdução: A cirurgia pancreática continua associada a uma elevada morbimortalidade mesmo em centros de referência. O objetivo do presente estudo foi avaliar a influência da composição corporal nas complicações e sobrevivência após cirurgia pancreática. Métodos: Estudo retrospetivo em doentes submetidos a cirurgia pancreática entre Março 2012 e Dezembro 2017. Foram registadas variáveis demográficas, clínicas, complicações pós-cirúrgicas classificadas de acordo com a classificação de a classificação de Clavien Dindo. A composição corporal foi avaliada utilizando imagens de Tomografia Axial Computorizada (TAC) realizada no diagnóstico. Modelos de riscos porporcionais de Cox foram ajustados. Resultados: Incluídos 90 doentes, 55% homens e média de idade de 68 ± 10.9 anos; 92% submetidos a pancreatectomia/pancreatoduodenectomia, 7% pancreatectomia distal e 1% pancreatoduodenectomia com ressecção multivisceral; 84% tinham doença maligna. A incidência de complicações major foi de 27.8% e a mortalidade aos 90 dias de 8.8%. O racio da Área de Gordura Visceral (AGV) / Área de Tecido Muscular Esquelético (ATME) associou-se a um risco acrescido de complicações (OR 2.24, 95% CI 1.14-4.87, p = 0.03) e de morte aos 90 dias (HR 2.13, 95% CI 1.13-4.01, p = 0.019). Observámos uma sobrevivência global mais baixa em doentes com idade ≥70 anos (p = 0.0009), com complicações ≥IIIb (p = 0.01), com AGV/ ATME aumentada e atenuação muscular diminuída (p = 1.6 × 10-5). A atenuação muscular ajustada para a idade, malignidade, complicações, manteve-se associada à sobrevivência global (HR 0.94, IC 95% 0.90-0.98, p = 0.0016). Um modelo que inclua apenas variáveis de composição corporal mostrou uma capacidade discriminatória (C-statistic 0.76) superior a um modelo convencional com variáveis clínicas (C-statistic 0.68). Conclusão: A composição corporal é um determinante major de complicações pós-cirúrgicas e de sobrevivência de doentes submetidos a cirurgia pancreática.

Abstract: Introduction: Pancreatic surgery still carries a high morbidity and mortality even in specialized centers. The aim of this study was to evaluate the influence of patients’ body composition on postoperative complications and survival after pancreatic surgery. Methods: This was a retrospective study on patients undergoing pancreatic surgery between March 2012 and December 2017. Demographics, clinical data, and postoperative complications classified according to Clavien-Dindo were recorded. Body composition was assessed using routine diagnostic or staging computed tomography (CT). Multiple Cox proportional hazards models were adjusted. Results: Ninety patients were included, 55% were male, and the mean age was 68 ± 10.9 years. Of these 90, 92% had a total pancreatectomy or pancreaticoduodenectomy, 7% a distal pancreatectomy, and 1% a pancreaticoduodenectomy with multi-visceral resection; 84% had malignant disease. The incidence of major complications was 27.8% and the 90-day mortality was 8.8%. The ratio of visceral fat area/skeletal muscle area (VFA:SMA) was associated with an increased risk of complications (OR 2.24, 95% CI 1.14-4.87, p = 0.03) and 90-day survival (HR 2.13, 95% CI 1.13-4.01, p = 0.019). On simple analysis, shorter overall survival (OS) was observed in patients aged ≥70 years (p = 0.0009), with postoperative complications ≥IIIb (p = 0.01), an increased VFA:SMA (p = 0.007), and decreased muscle radiation attenuation (p = 1.6 × 10-5). In an OS model adjusted for age, disease malignancy, postoperative complications, and body composition parameters, muscle radiation attenuation remained significantly associated with survival (HR 0.94, 95% CI 0.90-0.98, p = 0.0016). A model which included only body composition variables had a discrimination ability (C-statistic 0.76) superior to a model which comprised conventional clinical variables (C-statistic 0.68). Conclusion: Body composition is a major determinant of postoperative complications and survival in pancreatic surgery patients.

https://doi.org/10.1159/000507206 40 downloads

11.

Prevalence of infection by Bartonella spp. in patients with psoriasis,
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Luciene Silva dos

; Drummond, Marina Rovani

; Magalhães, Renata Ferreira

; Silva, Marilene Neves da

; Ferreira, Patricia Andreia Rodrigues

; Ferreira Velho, Paulo Eduardo Neves

Anais Brasileiros de Dermatologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

feb 2021, Volume 96 N. 1 Pages 107 - 110

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2020.07.004 224 downloads

12.

Qualidade de vida e desfechos em longo prazo após hospitalização por COVID-19: Protocolo para um estudo de coorte prospectivo (Coalizão VII)
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Rosa, Regis Goulart

; Robinson, Caroline Cabral

; Veiga, Viviane Cordeiro

; Cavalcanti, Alexandre Biasi

; Azevedo, Luciano César Pontes de

; Machado, Flávia Ribeiro

; Berwanger, Otavio

; Avezum, Álvaro

; Lopes, Renato Delascio

; Lisboa, Thiago Costa

; Teixeira, Cassiano

; Zampieri, Fernando Godinho

; Tomazini, Bruno Martins

; Kawano-Dourado, Letícia

; Schneider, Daniel

; Souza, Denise de

; Santos, Rosa da Rosa Minho dos

; Silva, Sabrina Souza da

; Trott, Geraldine

; Gimenes, Bruna dos Passos

; Souza, Ana Paula de

; Barroso, Bruna Machado

; Costa, Lauren Sezerá

; Brognoli, Liége Gregoletto

; Pelliccioli, Melissa Pezzetti

; Studier, Nicole dos Santos

; Schardosim, Raíne Fogliati de Carli

; Haubert, Tainá Aparecida

; Pallaoro, Victoria Emanuele Lobo

; Oliveira, Debora Mariani de

; Velho, Pedro Isaacsson

; Medeiros, Gregory Saraiva

; Gazzana, Marcelo Basso

; Zavascki, Alexandre Prehn

; Pitrez, Paulo Márcio

; Oliveira, Roselaine Pinheiro de

; Polanczyk, Carisi Anne

; Nasi, Luiz Antônio

; Hammes, Luciano Serpa

; Falavigna, Maicon

Revista Brasileira de Terapia Intensiva

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jan 2021, Volume 33 N. 1 Pages 31 - 37

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Os efeitos provocados pela COVID-19 em longo prazo são desconhecidos. O presente estudo tem como objetivo avaliar os fatores associados com a qualidade de vida relacionada à saúde e os desfechos em longo prazo em sobreviventes à hospitalização por COVID-19 no Brasil. Métodos: Este será um estudo multicêntrico de coorte prospectivo, aninhado em cinco ensaios clínicos randomizados desenhados para avaliar os efeitos dos tratamentos específicos para COVID-19 em mais de 50 centros no Brasil. Pacientes adultos sobreviventes à hospitalização por infecção por SARS-CoV-2 comprovada ou suspeita serão seguidos por um período de 1 ano, por meio de entrevistas telefônicas estruturadas. O desfecho primário é o escore de utilidade para qualidade de vida relacionada à saúde após 1 ano, avaliado segundo o questionário EuroQol-5D3L. Os desfechos secundários incluirão mortalidade por todas as causas, eventos cardiovasculares graves, reospitalizações, retorno ao trabalho ou estudo, condição funcional física avaliada pelo instrumento Lawton-Brody Instrumental Activities of Daily Living, dispneia avaliada segundo a escala de dispneia modificada do Medical Research Council, necessidade de suporte ventilatório em longo prazo, sintomas de ansiedade e depressão avaliados segundo a Hospital Anxiety and Depression Scale, sintomas de transtorno de estresse pós-traumático avaliados pela ferramenta Impact of Event Scale-Revised e autoavaliação da condição de saúde, conforme a Escala Visual Analógica do EuroQol-5D3L. Serão utilizadas equações de estimativas generalizada para testar a associação entre cinco conjuntos de variáveis (1 - características demográficas, 2 - condição de saúde pré-morbidade, 3 - características da doença aguda, 4 - terapias específicas para COVID-19 recebidas e 5 - variáveis pós-alta atualizadas) e desfechos. Ética e disseminação: O protocolo do estudo foi aprovado pelos Comitês de Ética em Pesquisa de todas as instituições participantes. Os resultados serão disseminados por meio de conferências e periódicos revisados por pares.

Abstract Introduction: The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil. Methods: This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes. Ethics and dissemination: The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.

https://doi.org/10.5935/0103-507x.20210003 2053 downloads

13.

Spinal cord and cutaneous involvement in paracoccidioidomycosis
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

França, Andrea Fernandes Eloy da Costa

; Velho, Paulo Eduardo Neves Ferreira

; Reis, Fabiano

Revista da Sociedade Brasileira de Medicina Tropical

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 54 elocation e0115-2021

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0037-8682-0115-2021 111 downloads

14.

Atypical cutaneous mycobacteriosis caused by M. fortuitum acquired in domestic environment,
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Silva, Dimitri Luz Felipe da

; Valandro, Letícia dos Santos

; Velho, Paulo Eduardo Neves Ferreira

; França, Andréa Fernandes Eloy da Costa

Anais Brasileiros de Dermatologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2020, Volume 95 N. 3 Pages 390 - 391

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2019.06.012 189 downloads

15.

Bartonella henselae infection induces a persistent mechanical hypersensitivity in mice
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Vieira-Damiani, Gislaine

; Almeida, Amanda Roberta de

; Silva, Marilene Neves

; Lania, Bruno Groseli

; Soares, Tânia Cristina Benetti

; Drummond, Marina Rovani

; Lins, Karina A.

; Ericson, Marna

; Gupta, Kalpna

; Velho, Paulo Eduardo Neves Ferreira

Revista do Instituto de Medicina Tropical de São Paulo

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2020, Volume 62 elocation e79

Abstract: En | Text: En | PDF: En

ABSTRACT Bartonella spp. are re-emerging and neglected bacterial pathogens. The natural reservoirs for several species of this genus are domestic animals such as cats and dogs, the most common pets in the USA and Brazil. Some cat studies suggest that the infection is more prevalent in tropical and poverty-stricken areas. These bacteria were associated with a wide spectrum of clinical manifestations: fever of unknown origin, endocarditis, angiomatosis, chronic lymphadenopathy, hepatitis, fatigue, paresthesia and pain. Our group has already demonstrated that B. henselae -infected sickle cell disease mice present with hyperalgesia. We hypothesized that even immunocompetent mice infected by B. henselae would show an increased and persistent mechanical sensitivity. Five ten-week old male BALB/c mice were intraperitoneally inoculated with a 30 µL of suspension containing 10 4 CFU/mL of B. henselae, while five others were inoculated with an equal volume of saline solution. Four days after bacterial inoculation, the mechanical paw withdrawal threshold was measured using von Frey filaments in all animals, for five consecutive days. The infected animals showed hypersensitivity to mechanical stimuli for five consecutive days. The present study has demonstrated that B. henselae infection induces persistent mechanical hypersensitivity, a signal consistent with pain.

https://doi.org/10.1590/s1678-9946202062079 340 downloads

Showing

itens per page

Page of 6 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »