RESUMO Objetivo: Compreender a vivência de enfermeiros que atuam na Unidade de Terapia Intensiva com pacientes infectados pela COVID-19. Método: Pesquisa qualitativa, ancorada na fenomenologia social de Alfred Schütz, que entrevistou 20 enfermeiros atuantes em Unidades de Terapia Intensiva de hospitais públicos e privados, entre julho e setembro de 2020. Os dados foram analisados de acordo com o referencial teórico-metodológico adotado e com a literatura pertinente à temática. Resultados: Os enfermeiros apontam demandas relacionadas às condições de trabalho, valorização e capacitação profissional, além do apoio à saúde física e mental, considerando-se a intensidade do cuidado vivenciado durante a pandemia. Conclusão: A compreensão da vivência dos enfermeiros mostrou que houve necessidade de adaptação a esse novo modo de cuidar que inclui o espaço físico, novos protocolos institucionais, uso contínuo de equipamentos de proteção e cuidado diferenciado requerido pelos pacientes. Isso gerou a necessidade de conviver com situações que interferiam em sua saúde, bem como na motivação para realização de projetos para a vida profissional, após a pandemia pelo novo coronavírus.

ABSTRACT Objective: To understand the experiences of intensive care unit nurses who provide care to patients with COVID-19. Methods: Qualitative study grounded in Alfred Schütz’s social phenomenology in which 20 nurses who work in intensive care units at public and private hospitals were interviewed between July and September 2020. Data were analyzed according to the adopted theoretical-methodological framework and the literature related to the subject. Results: The interviewed nurses mentioned demands about working conditions, professional recognition and training, and support to physical and mental health, which proved necessary considering the care intensity experienced by these professionals during the COVID-19 pandemic. Conclusion: Learning the nurses’ experiences evidenced the need to adjust to a new way of providing care that included the physical space, new institutional protocols, continuous use of protective equipment, and patients’ demand for special care. This originated the necessity to be around situations that interfered with their health and motivated them to carry out professional projects after the COVID-19 pandemic.

RESUMEN Objetivo: Comprender la experiencia de enfermeros actuantes en Unidad de Terapia Intensiva con pacientes infectados por COVID-19. Método: Investigación cualitativa basada en la fenomenología social de Alfred Schütz, entrevistándose a 20 enfermeros actuantes en Unidades de Terapia Intensiva de hospitales públicos y privados, entre julio y setiembre de 2020. Datos analizados según referencial teórico-metodológico adoptado, y con literatura correspondiente al tema. Resultados: Los enfermeros manifiestan demandas relacionadas a condiciones laborales, valoración y capacitación profesional, además del apoyo a la salud física y mental, considerando la intensa atención practicada en pandemia. Conclusión: La comprensión de la experiencia de los enfermeros mostró que fue necesario adaptarse a ese nuevo modo de cuidar, que incluye espacio físico, nuevos protocolos institucionales, uso permanente de equipos de protección y atención diferenciada requerida por los pacientes. Esto generó necesidad de convivir con situaciones que interferían en su salud y en la motivación para realizar proyectos para la vida profesional luego de la pandemia por el nuevo coronavirus.

Resumo Introdução: A lesão renal aguda (LRA) é uma complicação ainda pouco estudada no contexto das pacientes obstétricas, que está associada com aumento da mortalidade. Objetivo: Investigar a frequência e os fatores de risco da LRA entre pacientes obstétricas. Métodos: Foi realizado estudo transversal com todas as pacientes admitidas em uma unidade de terapia intensiva (UTI) devido a complicações obstétricas em Fortaleza, Brasil, no período de janeiro de 2012 a dezembro de 2014. LRA foi definida de acordo com o critério AKIN. Resultados: Foram incluídas 389 pacientes, com idade entre 13 e 45 anos. As principais causas de admissão na UTI foram síndromes hipertensivas da gestação (54,5%), hemorragia e choque hemorrágico (12,3%), cardiopatias (9,0%), insuficiência respiratória (8,2%) e sepse (5,4%). LRA foi encontrada em 92 casos (24%), e esta foi a complicação mais frequente. A mortalidade geral foi de 7,5%, e a mortalidade por LRA foi de 21% (p = 0,0007). Na análise multivariada, os fatores de risco para LRA foram parto cesariano (IC 95% = 0,23-0,85, p = 0,01) e plaquetopenia (IC 95% = 1,50-4,36, p = 0,001). LRA foi um fator de risco independente para óbito (OR = 6,64, IC 95% = 3,11-14,15, p < 0,001). Conclusão: LRA foi a complicação mais frequente em pacientes obstétricas gravemente doentes e esteve associada com aumento da mortalidade. A maioria dos casos esteve associada às síndromes hipertensivas da gravidez, que são complicações passíveis de tratamento durante o pré-natal.

Abstract Introduction: Acute kidney injury (AKI) is a complication still poorly studied in the setting of obstetric patients, which is associated with increased mortality. Objective: The aim of this study was to investigate the frequency and risk factors of AKI among critically ill obstetric patients. Methods: A cross-sectional study was conducted with all patients admitted to an intensive care unit (ICU) due to obstetric complications, in Fortaleza, Brazil, in the period between January 2012 and December 2014. AKI was defined according to AKIN criteria. Results: A total of 389 patients were included, aged between 13 and 45 years. The main causes of ICU admission were pregnancy-related hypertensive syndromes (54.5%), hemorrhage and hemorrhagic shock (12.3%), heart diseases (9.0%), respiratory insufficiency (8.2%) and sepsis (5.4%). AKI was found in 92 cases (24%), and this was the most frequent complication. General mortality was 7.5%, and mortality due to AKI was 21% (p = 0.0007). In the multivariate analysis, risk factors for AKI were cesarian delivery (95% CI = 0.23-0.85, p = 0.01) and thrombocythopenia (95% CI = 1.50-4.36, p = 0.001). AKI was an independent risk factor for death (OR = 6.64, 95% CI = 3.11-14.15, p < 0.001). Conclusion: AKI was the main complication among critically ill obstetric patients and it was associated with increased mortality. Most cases were associated with pregnancy-related hypertensive disorders, which are complications that can be easily identified and treated during prenatal care.

ABSTRACT Bee stings can cause severe reactions and have caused many victims in the last years. Allergic reactions can be triggered by a single sting and the greater the number of stings, the worse the prognosis. The poisoning effects can be systemic and can eventually cause death. The poison components are melitin, apamin, peptide 401, phospholipase A2, hyaluronidase, histamine, dopamine, and norepinephrine, with melitin being the main lethal component. Acute kidney injury (AKI) can be observed in patients suffering from bee stings and this is due to multiple factors, such as intravascular hemolysis, rhabdomyolysis, hypotension and direct toxicity of the venom components to the renal tubules. Arterial hypotension plays an important role in this type of AKI, leading to ischemic renal lesion. The most commonly identified biopsy finding in these cases is acute tubular necrosis, which can occur due to both, ischemic injury and the nephrotoxicity of venom components. Hemolysis and rhabdomyolysis reported in many cases in the literature, were demonstrated by elevated serum levels of indirect bilirubin and creatine kinase. The severity of AKI seems to be associated with the number of stings, since creatinine levels were higher, in most cases, when there were more than 1,000 stings. The aim of this study is to present an updated review of AKI associated with bee stings, including the currently advised clinical approach.

According to the Resource-Based View, the nature of the resources, competences and knowledge accumulated by firms are the major causes of variation in business performance. In view of the importance attributed to intangible assets, the purpose of the present study was to investigate whether innovative firms with superior and sustained performance and firms without superior and sustained performance differ with regard to investments in intangible assets. The sample consisted of 137 firms listed on the Brazilian stock exchange from 2007 to 2010 and belonging to innovative sectors according to the Brazilian Innovation Index. Only 51 firms with profitability above the sector average during the entire study period (four years) met the criterion of superior and sustained performance. Thus, using return on assets as a proxy for performance, investments in intangibles were found to be greater in firms without superior and sustained performance, particularly with regard to the categories intellectual property assets(the predominant category) and infrastructure assets. Based on the lack of evidence for a significant correlation between corporate performance and investment in intangible assets, our initial hypothesis that a positive relation exists between the composition of investments in intangible assets and the performance of innovative firms could not be confirmed.

OBJETIVO: Investigar as alterações histopatológicas produzidas por um modelo de trauma craniano fechado por queda de peso em ratos. MÉTODOS: Utilizando uma plataforma para produção de lesão craniana fechada controlada por queda de peso com energia pré-definida e conhecida, 25 ratos Wistar machos (Rattus norvegicus albinus) foram divididos em cinco grupos iguais que receberam níveis diferentes de energia de impacto craniano: G1, G2, G3 e G4 com 0,234J, 0,5J, 0,762J e 1J respectivamente e G5 (Sham). Sob analgesia, cada grupo teve seus encéfalos coletados e processados para análise histopatológica por microscopia óptica convencional. RESULTADOS: Houve maior número de neurônios lesados em animais do grupo 4, mas morte neuronal também pôde ser constatada nos animais do grupo 5. Hemorragias parenquimatosas foram mais frequentes nos animais do grupo 4 e o inchaço cerebral citotóxico e congestão vascular foram mais intensos neste grupo. CONCLUSÃO: Os achados à análise histopatológica permitem observar alterações típicas do trauma craniano e estas guardaram proporção direta com a energia do impacto.

PURPOSE: To study histopathological findings due to a model of closed head injury by weight loss in rats. METHODS: A platform was used to induce closed cranial lesion controlled by weight loss with a known and predefined energy. 25 male Wistar rats (Rattus novergicus albinus) were divided in five equal groups which received different cranial impact energy levels: G1, G2, G3 and G4 with 0.234J, 0.5J, 0.762J and 1J respectively and G5 (Sham). Under the effect of analgesia, the brain of each group was collected and prepared for histopathological analysis by conventional optic microscopy. RESULTS: It was observed greater number of injured neurons in animals of group 4, however neuronal death also could be noticed in animals of group 5. Intraparenchymal hemorrhages were more frequent in animals of group 4 and the cytotoxic brain swelling and vascular congestion were more intense in this group CONCLUSION: The histopathological analysis of these findings allowed to observe typical cranial trauma alterations and these keep close relation with impact energy.

Esta pesquisa foi baseada no trabalho de Miranda; Poméia; Bueno (2004), o qual defende que fatores culturais e a faixa etária dos alunos são questões que influenciam na percepção humana, e entende que algumas imagens são convencionalmente designadas para diferentes culturas (como a norte-americana e a brasileira). A presente proposta não teve a pretensão de substituir as notações utilizadas para a classificação de assuntos em bibliotecas, amplamente difundidas (notações numéricas da CDD, CDU, etc.), mas sim, sugerir o que esta pesquisa denomina de "rotulação" destes assuntos através de imagens, para que melhor possam representá-los. Acredita-se que o objetivo da pesquisa foi alcançado: ordenamento mais claro dos materiais da biblioteca. Sugere-se o desenvolvimento desse sistema de imagens de classificação como forma alternativa de organização de bibliotecas contendo, em seu acervo literatura infantojuvenil.

This research was based on work by Miranda; Poméia; Bueno (2004), which argues that cultural factors and age of the students are issues that influence the human perception, and that some images are conventionally designated for different crops (such as North American and Brazilian). This proposal was not the intention of replacing the notations used for the classification of issues in libraries, widely distributed (numerical ratings of the CDD, CDU, etc), but suggest that this research calls "labeling" of these matters through images, that can best represent them. It is believed that the goal of the research was achieved: planning clear materials from the library. It suggests that development of this system of classification of images as an alternative organization of libraries containing its achievements in children's literature.

OBJETIVO: Investigar o uso de um modelo de trauma craniano experimental em ratos. MÉTODOS: O equipamento, já descrito na literatura e sob discretas adaptações, contitui-se de uma plataforma para produção de lesão craniana fechada controlada por queda de peso com energia pré-definida e conhecida. 25 ratos Wistar machos (Rattus norvegicus albinus) foram divididos em cinco grupos iguais que receberam níveis diferentes de energia de impacto craniano: G1, G2, G3 e G4 com 0,234J, 0,5J, 0, 762J e 1J respectivamente e G5 (Sham). Sob intensa analgesia, cada grupo foi avaliado clinicamente em uma seqüência de intervalos e tiveram seus encéfalos removidos para análise patológica. RESULTADOS: Alterações clínicas importantes (convulsões, bradicardia, bradipnéia e posturas anormais) e patológicas focais (hematomas e hemorragias) guardaram proporção com a intensidade do impacto. Nenhuma fratura foi observada e o grupo 4 teve 80% de mortalidade. CONCLUSÃO: O modelo animal para trauma craniano experimental por queda de peso é uma alternativa de baixo custo e fácil reprodução, gerando alterações clínicas e patológicas compatíveis com os objetivos de estudos em cirurgia experimental para abordagem do trauma craniano em ratos.

PURPOSE: To investigate the function of an experimental cranium trauma model in rats. METHODS: The equipment, already described in the literature and under discreet adaptations, is composed by a platform that produces closed head impact controlled by weight drop with pre-defined and known energy. 25 Wistar male rats (Rattus norvegicus albinus) were divided into five equal groups that received different quantities of cranial impact energy: G1, G2, G3 and G4 with 0,234J, 0,5J, 0,762J and 1J respectively and G5 (Sham). Under intense analgesia, each group was evaluated clinically in a sequence of intervals and had their encephalon removed for pathologic analysis. RESULTS: Important clinical alterations (convulsions, bradycardia, bradypnea and abnormal postures) and focal pathologic (hematomas and hemorrhages) kept proportion with the intensity of the impact. No fracture was observed and the group 4 had 80% mortality rate. CONCLUSION: The experimental cranium trauma animal model by weight drop is an alternative of low cost and easy reproduction that allows evaluating clinical and pathological alterations in accordance with studies in experimental surgery aims for new traumatic brain injury approach in rats.