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Entomogenous galls and their associated fauna in deciduous dry forest and woodland vegetation remnants (Caatinga) in the Northern Depressão Sertaneja, Brazil
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Marinho, Rafael Aguiar

; Maia, Valéria Cid

; Barbosa, Maria Regina de Vasconcellos

Biota Neotropica

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2023, Volume 23 N. 1 elocation e20221428

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract A survey and characterization of entomogenous galls and their associated fauna were carried out in six remnants of Caatinga in the Northern Depressão Sertaneja, in the states of Paraíba, Rio Grande do Norte and Ceará. We identified 41 gall morphotypes in 24 plant species, belonging to 12 botanical families. Fabaceae had 29.2% (n = 12) of the total number of gall morphotypes found. Leaves (61%) and stems (25%) were the most attacked organs. Most morphotypes are glabrous (75.6%), while only 24.4% exhibit trichomes. Most galls were induced by insects of the Cecidomyiidae family. The associated fauna comprised successors, cecidophages, tenants, and parasitoids. Sucessors were found in four morphotypes of galls and included spiders and four orders of insects: Hemiptera, Coleoptera, Lepidoptera, and Hymenoptera (Formicidae). The tenants were represented by Tanaostigmoides (Tanaostigmatidae). The parasitoids, found in 18 morphotypes (43.9%), were represented by six families of Hymenoptera. We recorded the occurrence of new types of galls in 12 species of host plants. These gall records are new references for the Northern Depressão Sertaneja in the studied states.

Resumo Realizou-se um levantamento e caracterização de galhas entomógenas e sua fauna associada em seis remanescentes de Caatinga presentes na Depressão Sertaneja Setentrional nos estados da Paraíba, Rio Grande do Norte e Ceará. Identificamos 41 morfotipos de galhas em 24 espécies de plantas, pertencentes a 12 famílias botânicas. Fabaceae abrigou 29,2% (n = 12) do total de morfotipos de galhas encontrados. As folhas (61%) e os caules (25%) foram os órgãos mais atacados. A maioria dos morfotipos é glabra (75,6%), enquanto apenas 24,4% exibiram tricomas. As galhas, em sua maioria, foram induzidas por insetos da família Cecidomyiidae. A fauna associada compreendeu sucessores, fungívoros, inquilinos e parasitoides. Os primeiros foram encontrados em quatro morfotipos de galhas, estando representados por aranhas e quatro ordens de insetos: Hemiptera, Coleoptera, Lepidoptera e Hymenoptera (Formicidae). Os inquilinos foram representados por Tanaostigmoides Ashmead, 1896 (Tanaostigmatidae). Já os parasitoides, encontrados em 18 morfotipos de galhas (43,9%), foram representados por seis famílias de Hymenoptera. Registramos a ocorrência de novos tipos de galhas em 12 espécies de plantas hospedeiras. Os registros de galhas também são novas referências para a Depressão Sertaneja Setentrional nos estados estudados.

https://doi.org/10.1590/1676-0611-bn-2022-1428

Validation of pairs of antagonist teeth for the evaluation of shortened dental arch in epidemiological studies
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CAMPOS, Fernanda Lamounier

; RHODES, Gabriela Aparecida Caldeira

; VASCONCELLOS, Walison Arthuso

; BOMFIM, Rafael Aiello

; SAMPAIO, Aline Araujo

; CHALUB, Loliza Luiz Figueiredo Houri

; FERREIRA, Raquel Conceição

Brazilian Oral Research

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2023, Volume 37 elocation e045

Abstract: En | Text: En | PDF: En

Abstract The aim of this study was to evaluate the accuracy of pairs of antagonist teeth (epidemiological criterion) for defining pairs of teeth in occlusal contact (clinical criterion) and to estimate the agreement between the prevalence of “shortened dental arch” (SDA) and “functional dentition” (FD) when occlusal units (OUs) or posterior occluding pairs (POPs) are defined by the epidemiological or clinical criterion. Data were collected in an epidemiological oral health survey conducted in a municipality in Minas Gerais, Brazil. OUs and POPs were defined by the epidemiological criterion (dental crown status) or clinical criterion “gold standard” (carbon paper record of occlusal contacts during habitual maximum intercuspation). SDA corresponded to the presence of an intact anterior region and three to five OUs. FD was based on the concomitant presence of ≥ 1 tooth in each arch, 10 teeth in each arch, 12 anterior teeth, ≥ 3 premolar POPs, and ≥ 1 molar POP bilaterally. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of the epidemiological criterion were calculated. The study included 197 adults. Sensitivity, specificity, PPV, and NPV were 88.5, 87.9, 92.5, and 81.9%, respectively, and accuracy was 88.3%. The epidemiological criterion proved to be valid and could be used in epidemiological studies to calculate the prevalence of reduced dental configurations that consider POPs. The assessment of oral functionality is an aspect that should be included in the diagnosis of the clinical condition of patients, contributing to a more effective individual and collective oral health care plan.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0045

Discovery of new Schistosoma mansoni aspartyl protease inhibitors by structure-based virtual screening
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Gomes, Bárbara Figueira

; Senger, Mario Roberto

; Moreira-Filho, José Teófilo

; Vasconcellos Junior, Fabio Jorge de

; Dantas, Rafael Ferreira

; Owens, Raymond

; Andrade, Carolina Horta

; Neves, Bruno Junior

; Silva-Junior, Floriano Paes

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e230031

Abstract: En | Text: En | PDF: En

BACKGROUND Schistosomiasis is a neglected tropical disease caused by trematodes of the genus Schistosoma, with a limited treatment, mainly based on the use of praziquantel (PZQ). Currently, several aspartic proteases genes have already been identified within the genome of Schistosoma species. At least one enzyme encoded from this gene family (SmAP), named SmCD1, has been validated for the development of schistosomicidal drugs, since it has a key role in haemoglobin digestion by worms. OBJECTIVE In this work, we integrated a structure-based virtual screening campaign, enzymatic assays and adult worms ex vivo experiments aiming to discover the first classes of SmCD1 inhibitors. METHODS Initially, the 3D-structures of SmCD1, SmCD2 and SmCD3 were generated using homology modelling approach. Using these models, we prioritised 50 compounds from 20,000 compounds from ChemBridge database for further testing in adult worm aqueous extract (AWAE) and recombinant SmCD1 using enzymatic assays. FINDINGS Seven compounds were confirmed as hits and among them, two compounds representing new chemical scaffolds, named 5 and 19, had IC50 values against SmCD1 close to 100 μM while presenting binding efficiency indexes comparable to or even higher than pepstatin, a classical tight-binding peptide inhibitor of aspartyl proteases. Upon activity comparison against mammalian enzymes, compound 50 was selective and the most potent against the AWAE aspartic protease activity (IC50 = 77.7 μM). Combination of computational and experimental results indicate that compound 50 is a selective inhibitor of SmCD2. Compounds 5, 19 and 50 tested at low concentrations (10 uM) were neither cytotoxic against WSS-1 cells (48 h) nor could kill adult worms ex-vivo, although compounds 5 and 50 presented a slight decrease on female worms motility on late incubations times (48 or 72 h). MAIN CONCLUSION Overall, the inhibitors identified in this work represent promising hits for further hit-to-lead optimisation.

https://doi.org/10.1590/0074-02760230031

DESIGUALDADE, EXPULSÕES E RESISTÊNCIAS SOCIAIS: pensando o local e o global
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Menezes, Roberto Goulart

; Vasconcellos, Patrícia Mara Cabral de

; Scotelaro, Marina

; Mello, Rafael Alexandre

Caderno CRH

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2022, Volume 35 elocation e022003

Abstract: Pt En Fr | Text: Pt En Fr | PDF: Pt | PDF: En | PDF: Fr

O artigo analisa o processo de desigualdades sociais do período recente do capitalismo histórico, com ênfase no acirramento da iniquidade e como ela impacta nos meios de luta dos movimentos sociais. Primeiro, apresentamos o debate teórico-metodológico sobre desigualdade, a lógica das expulsões, os novos riscos sociais e suas consequências para a democracia contemporânea. Em seguida, avaliamos como os movimentos sociais têm lutado contra a desigualdade e a retirada de direitos por meio de novas formas de articulação, manifestação e formação de movimentos antissistêmicos. Partindo do debate agência-estrutura, demonstramos como o local e o global se entrelaçam na dinâmica das desigualdades e a luta dos diferentes movimentos sociais. E, por fim, apontamos os principais desafios para que os movimentos recuperem sua capacidade de promover a emancipação social.

This article analyzes the process of social inequalities in the recent historical capitalism, highlighting its intensification and how it impacts the means of struggle used by social movements. First, we present the theoretical and methodological debate on inequality, the logic of expulsions, the new social risks, and their consequences for contemporary democracy. Then, we evaluate how social movements have fought against inequality and the stripping of rights by new forms of articulation, manifestation and formation of anti-systemic movements. Based on the agency-structure debate, we show how the local and the global are intertwined in the dynamics of inequality and the struggle of different social movements. Finally, we point out the main challenges for movements to recover their capacity to promote social emancipation.

L’article analyse la démarche des inégalités sociales dans la période récente du capitalisme historique, en soulignant son intensification et son impact sur les moyens de lutte des mouvements sociaux. Dans la première partie, nous présentons le débat théorico-méthodologique sur les inégalités, la logique des expulsions, les nouveaux risques sociaux et leurs conséquences sur la démocratie contemporaine. Ensuite, nous évaluons comment les mouvements sociaux ont lutté contre les inégalités et le retrait des droits à travers de nouvelles formes d’articulation, de manifestation et de formation des organisations anti-systémiques. En s’appuyant dur le débat agence-structure, nous démontrons comment le local et le global s’entremêlent dans la dynamique des inégalités et la lutte des différents mouvements sociaux. Enfin, nous soulignons les principaux défis que les mouvements doivent relever pour retrouver leur capacité à promouvoir l’émancipation sociale.

https://doi.org/10.9771/ccrh.v35i0.48419

Aspectos espacial e temporal e fatores associados à interiorização da Covid-19 em Pernambuco, Brasil
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Quinino, Louisiana Regadas de Macedo

; Vasconcellos, Flávia Helena Manhães

; Diniz, Isabel Soares

; Aguiar, Lucilene Rafael

; Ramos, Yasmim Talita de Moraes

; Bastiani, Fernanda De

Ciência & Saúde Coletiva

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jun 2021, Volume 26 N. 6 Pages 2171 - 2182

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Análise espacial e temporal da interiorização da Covid-19 em Pernambuco, considerando-se os fatores socioeconômicos correlacionados. Estudo ecológico, março a junho de 2020. Geraram-se mapas a partir do coeficiente de incidência por município de residência para determinar a dinâmica espacial da Covid-19. Estudou-se a correlação entre indicadores socioeconômicos e o coeficiente nas regiões metropolitana do Recife (RMR) e interior. Suavizou-se este coeficiente e calculou-se o teste de Moran global. Os primeiros casos foram registrados em Recife e arredores. O caminho para a autoctonia se deu em municípios vizinhos e naqueles supridos por grandes rodovias. A maior incidência na RMR (640,22/100.000 hab) correlacionou-se à maior população e densidade demográfica e menor taxa de urbanização e IDH-M. No interior a incidência (361,29/100.000 hab) esteve correlacionada à maior população, densidade demográfica e taxa de urbanização, e menor área (p<0,05). As áreas de maior risco concentraram-se na RMR, mas o interior apresentou áreas de transição, indicando tendência à interiorização (p<0,05). Ter ciência do padrão de distribuição espacial da Covid-19, aliada aos fatores associados poderão contribuir para maior efetividade das ações de controle.

Abstract This study involved an ecological study between March and June 2020 consisting of a spatial and temporal analysis of the spread of Covid-19 to the interior of Pernambuco and related socioeconomic factors. Maps were generated from the incidence coefficient by municipality of residence to determine the spatial dynamics of Covid-19. The correlation between socioeconomic indicators and the coefficient in the metropolitan regions of Recife (MRR) and inland regions was studied. This coefficient was levelled, and the global Moran test was applied. The first cases were recorded in and around Recife. The spread of the virus took place in neighboring municipalities and in those served by major highways. The highest incidence in MRR (640.22/100,000 inhabitants) was correlated to larger population and demographic density and lower rate of urbanization and IDH-M. Inland, the incidence (361.29/100,000 inhabitants) was correlated with a larger population, demographic density and urbanization rate, and a smaller area (p<0.05). The areas of greatest risk were concentrated in MRR, but the interior showed areas of transition, indicating a tendency to spread (p<0.05). Being aware of the spatial distribution pattern of Covid-19, combined with the associated factors, may contribute to greater effectiveness of control actions.

https://doi.org/10.1590/1413-81232021266.00642021 332 downloads

Aspectos espacial e temporal e fatores associados à interiorização da Covid-19 em Pernambuco, Brasil
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Quinino, Louisiana Regadas de Macedo

; Vasconcellos, Flávia Helena Manhães

; Diniz, Isabel Soares

; Aguiar, Lucilene Rafael

; Ramos, Yasmim Talita de Moraes

; Bastiani, Fernanda De

Ciência & Saúde Coletiva

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jun 2021, Volume 26 N. 6 Pages 2171 - 2182

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021266.00642021

Pseudoaneurisma roto de artéria ileocólica: relato de caso
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Sant’Anna, Carolina Vasconcellos

; Kuhl, Felipe Garcia

; Leite, Alane Miranda

; Oliveira Raymundo, Selma Regina de

; Miquelin, André Rodrigo

; Acar, Vitória

; Fachini, Vitor Brumato

; Canuti, Matheus Rafael

Jornal Vascular Brasileiro

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2021, Volume 20 elocation e20210163

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os aneurismas de artérias viscerais (AAVs) e pseudoaneurismas de artérias viscerais (PAAVs) são condições raras e potencialmente letais quando rotos. Em geral, são encontrados incidentalmente na tomografia computadorizada de pacientes assintomáticos. Embora a cirurgia aberta convencional seja considerada atualmente o tratamento padrão ouro, a abordagem endovascular vem ganhando relevo por ser considerada um procedimento minimamente invasivo e com riscos cirúrgicos menores. Destaca-se, nessa abordagem, o uso de embolização por molas (coils) em AAVs e PAAVs saculares e implante de stent modulador de fluxo como alternativa de tratamento para aneurismas fusiformes. Apresentamos o caso de uma paciente de 51 anos com queixa de dor abdominal aguda, taquicardia e hipotensão, com evidência de sangramento abdominal em angiotomografia e diagnóstico de pseudoaneurisma de artéria ileocólica (AIC) roto. Ela foi submetida a tratamento endovascular precoce de embolização da AIC com sucesso, e houve melhora do quadro clínico.

Abstract Visceral artery aneurysms (VAAs) and visceral artery pseudoaneurysms (VAPAs) are rare conditions and are potentially lethal when they rupture. They are usually found as incidental findings on computed tomography (CT) scans of asymptomatic patients. Although conventional open surgery is currently considered the gold standard treatment, the endovascular approach has gained prominence as a minimally invasive procedure with lower surgical risk. In this approach, use of coil embolization in saccular VAAs and VAPAs and implantation of flow-modulating stents constitute alternative treatments for fusiform aneurysms. We present the case of a 51-year-old female patient complaining of acute abdominal pain, tachycardia, and hypotension, with evidence of abdominal bleeding on CT angiography, who was diagnosed with a ruptured ileocolic artery (ICA) pseudoaneurysm. She underwent early endovascular treatment for ICA embolization, which was successful and achieved clinical improvement.

https://doi.org/10.1590/1677-5449.210163

Electroanalytical Method for Determination of Trace Metals in Struvite Using Electrochemically Treated Screen-Printed Gold Electrodes
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Vasconcellos, Maria L. S.

; Rocha, Diego P.

; Castro, Sílvia V. F.

; Silva, Luiz R.G. e

; Muñoz, Rodrigo A. A.

; Freitas, Marcos B. J. G.

; Ferreira, Rafael Q.

Journal of the Brazilian Chemical Society

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sep 2020, Volume 31 N. 9 Pages 1873 - 1882

Abstract: En | Text: En | PDF: En

We present an electroanalytical method using square-wave anodic stripping voltammetry on electrochemically-treated screen-printed gold electrodes to the simultaneous determination of lead(II), copper(II) and mercury(II) in struvite (natural fertilizer produced from urine). Electrochemical treatment via cyclic voltammetry of the working electrodes increased surface rugosity that improved the electroanalytical responses for the three metals. Under optimized conditions and using a deposition time of 90 s, the proposed method presented the following limit of detection values: 1.3 µg L-1 for lead(II), 2.0 µg L-1 for copper(II) and 0.9 µg L-1 for mercury(II). Struvite samples were easily dissolved in supporting electrolyte solution (0.05 mol L-1 HCl). Satisfactory recovery values between 91 and 111% were obtained for the analysis of spiked samples. Hence, we can infer that the proposed electroanalytical method is an effective alternative for the determination of trace metals, since it provides precise and accurate direct analyses, with rapid responses without interference from sample matrix and enabling in field analysis.

https://doi.org/10.21577/0103-5053.20200081 404 downloads

Epidemiologia e desfecho dos pacientes de alto risco cirúrgico admitidos em unidades de terapia intensiva no Brasil
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Silva Júnior, João Manoel

; Chaves, Renato Carneiro de Freitas

; Corrêa, Thiago Domingos

; Assunção, Murillo Santucci Cesar de

; Katayama, Henrique Tadashi

; Bosso, Fabio Eduardo

; Amendola, Cristina Prata

; Serpa Neto, Ary

; Malbouisson, Luiz Marcelo Sá

; Oliveira, Neymar Elias de

; Veiga, Viviane Cordeiro

; Rojas, Salomón Soriano Ordinola

; Postalli, Natalia Fioravante

; Alvarisa, Thais Kawagoe

; Lucena, Bruno Melo Nobrega de

; Oliveira, Raphael Augusto Gomes de

; Sanches, Luciana Coelho

; Silva, Ulysses Vasconcellos de Andrade e

; Nassar Junior, Antonio Paulo

; Réa-Neto, Álvaro

; Amaral, Alexandre

; Teles, José Mário

; Freitas, Flávio Geraldo Rezende de

; Bafi, Antônio Tonete

; Pacheco, Eduardo Souza

; Ramos, Fernando José

; Vieira Júnior, José Mauro

; Pereira, Maria Augusta Santos Rahe

; Schwerz, Fábio Sartori

; Menezes, Giovanna Padoa de

; Magalhães, Danielle Dourado

; Castro, Cristine Pilati Pileggi

; Henrich, Sabrina Frighetto

; Toledo, Diogo Oliveira

; Parra, Bruna Fernanda Camargo Silva

; Dias, Fernando Suparregui

; Zerman, Luiza

; Formolo, Fernanda

; Nobrega, Marciano de Sousa

; Piras, Claudio

; Piras, Stéphanie de Barros

; Conti, Rodrigo

; Bittencourt, Paulo Lisboa

; D’Oliveira, Ricardo Azevedo Cruz

; Estrela, André Ricardo de Oliveira

; Oliveira, Mirella Cristine de

; Reese, Fernanda Baeumle

; Motta Júnior, Jarbas da Silva

; Câmara, Bruna Martins Dzivielevski da

; David-João, Paula Geraldes

; Tannous, Luana Alves

; Chaiben, Viviane Bernardes de Oliveira

; Miranda, Lorena Macedo Araújo

; Brasil, José Arthur dos Santos

; Deucher, Rafael Alexandre de Oliveira

; Ferreira, Marcos Henrique Borges

; Vilela, Denner Luiz

; Almeida, Guilherme Cincinato de

; Nedel, Wagner Luis

; Passos, Matheus Golenia dos

; Marin, Luiz Gustavo

; Oliveira Filho, Wilson de

; Coutinho, Raoni Machado

; Oliveira, Michele Cristina Lima de

; Friedman, Gilberto

; Meregalli, André

; Höher, Jorge Amilton

; Soares, Afonso José Celente

; Lobo, Suzana Margareth Ajeje

Revista Brasileira de Terapia Intensiva

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mar 2020, Volume 32 N. 1 Pages 17 - 27

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Definir o perfil epidemiológico e os principais determinantes de morbimortalidade dos pacientes cirúrgicos não cardíacos de alto risco no Brasil. Métodos: Estudo prospectivo, observacional e multicêntrico. Todos os pacientes cirúrgicos não cardíacos admitidos nas unidades de terapia intensiva, ou seja, considerados de alto risco, no período de 1 mês, foram avaliados e acompanhados diariamente por, no máximo, 7 dias na unidade de terapia intensiva, para determinação de complicações. As taxas de mortalidade em 28 dias de pós-operatório, na unidade de terapia intensiva e hospitalar foram avaliadas. Resultados: Participaram 29 unidades de terapia intensiva onde foram realizadas cirurgias em 25.500 pacientes, dos quais 904 (3,5%) de alto risco (intervalo de confiança de 95% - IC95% 3,3% - 3,8%), tendo sido incluídos no estudo. Dos pacientes envolvidos, 48,3% eram de unidades de terapia intensiva privadas e 51,7% de públicas. O tempo de internação na unidade de terapia intensiva foi de 2,0 (1,0 - 4,0) dias e hospitalar de 9,5 (5,4 - 18,6) dias. As taxas de complicações foram 29,9% (IC95% 26,4 - 33,7) e mortalidade em 28 dias pós-cirurgia 9,6% (IC95% 7,4 - 12,1). Os fatores independentes de risco para complicações foram Simplified Acute Physiology Score 3 (SAPS 3; razão de chance − RC = 1,02; IC95% 1,01 - 1,03) e Sequential Organ Failure Assessment Score (SOFA) da admissão na unidade de terapia intensiva (RC =1,17; IC95% 1,09 - 1,25), tempo de cirurgia (RC = 1,001; IC95% 1,000 - 1,002) e cirurgias de emergências (RC = 1,93; IC95% 1,10 - 3,38). Em adição, foram associados com mortalidade em 28 dias idade (RC = 1,032; IC95% 1,011 - 1,052) SAPS 3 (RC = 1,041; IC95% 1,107 - 1,279), SOFA (RC = 1,175; IC95% 1,069 - 1,292) e cirurgias emergenciais (RC = 2,509; IC95% 1,040 - 6,051). Conclusão: Pacientes com escores prognósticos mais elevados, idosos, tempo cirúrgico e cirurgias emergenciais estiveram fortemente associados a maior mortalidade em 28 dias e mais complicações durante permanência em unidade de terapia intensiva.

ABSTRACT Objective: To define the epidemiological profile and the main determinants of morbidity and mortality in noncardiac high surgical risk patients in Brazil. Methods: This was a prospective, observational and multicenter study. All noncardiac surgical patients admitted to intensive care units, i.e., those considered high risk, within a 1-month period were evaluated and monitored daily for a maximum of 7 days in the intensive care unit to determine complications. The 28-day postoperative, intensive care unit and hospital mortality rates were evaluated. Results: Twenty-nine intensive care units participated in the study. Surgeries were performed in 25,500 patients, of whom 904 (3.5%) were high-risk (95% confidence interval - 95%CI 3.3% - 3.8%) and were included in the study. Of the participating patients, 48.3% were from private intensive care units, and 51.7% were from public intensive care units. The length of stay in the intensive care unit was 2.0 (1.0 - 4.0) days, and the length of hospital stay was 9.5 (5.4 - 18.6) days. The complication rate was 29.9% (95%CI 26.4 - 33.7), and the 28-day postoperative mortality rate was 9.6% (95%CI 7.4 - 12.1). The independent risk factors for complications were the Simplified Acute Physiology Score 3 (SAPS 3; odds ratio - OR = 1.02; 95%CI 1.01 - 1.03) and Sequential Organ Failure Assessment Score (SOFA) on admission to the intensive care unit (OR = 1.17; 95%CI 1.09 - 1.25), surgical time (OR = 1.001, 95%CI 1.000 - 1.002) and emergency surgeries (OR = 1.93, 95%CI, 1.10 - 3.38). In addition, there were associations with 28-day mortality (OR = 1.032; 95%CI 1.011 - 1.052), SAPS 3 (OR = 1.041; 95%CI 1.107 - 1.279), SOFA (OR = 1.175, 95%CI 1.069 - 1.292) and emergency surgeries (OR = 2.509; 95%CI 1.040 - 6.051). Conclusion: Higher prognostic scores, elderly patients, longer surgical times and emergency surgeries were strongly associated with higher 28-day mortality and more complications during the intensive care unit stay.

https://doi.org/10.5935/0103-507x.20200005 1048 downloads

10.

Anticoagulation Therapy in Patients with Non-valvular Atrial Fibrillation in a Private Setting in Brazil: A Real-World Study
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Silva, Pedro Gabriel Melo de Barros e

; Sznejder, Henry

; Vasconcellos, Rafael

; Charles, Georgette M.

; Mendonca-Filho, Hugo Tannus F.

; Mardekian, Jack

; Nascimento, Rodrigo

; Dukacz, Stephen

; Fusco, Manuela Di

Arquivos Brasileiros de Cardiologia

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mar 2020, Volume 114 N. 3 Pages 457 - 466

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A segurança e a eficácia da varfarina dependem da qualidade do controle da anticoagulação. Estudos observacionais associam controle deficiente com aumento de morbidade, mortalidade e custos com saúde. Objetivos: Desenvolver um perfil de pacientes com fibrilação atrial não valvar (FANV) tratados com varfarina em ambiente ambulatorial e hospitalar privado brasileiro, avaliar a qualidade do controle da anticoagulação e sua associação com resultados clínicos e econômicos. Métodos: Este estudo retrospectivo, por meio de um conjunto de dados de seguros privados de saúde no Brasil, identificou pacientes com FANV tratados com varfarina entre 01 de maio de 2014 a 30 de abril de 2016, descreveu seu manejo da anticoagulação e quantificou os custos relacionados à doença. Foram recuperados dados demográficos, histórico clínico, medicação concomitante e tempo na faixa terapêutica (TTR) dos valores da razão normalizada internacional (RNI). Os pacientes foram agrupados em quartis de TTR, com um bom controle sendo definido como TTR ≥65% (método de Rosendaal). Sangramentos maiores e custos médicos diretos por todas as causas foram calculados e comparados entre subgrupos de controle bons e ruins. Valores de p < 0,05 foram considerados estatisticamente significantes. Resultados: A análise incluiu 1220 pacientes (mediana de seguimento: 1,5 anos; IIQ: 0,5-2,0). Em média, cada paciente recebeu 0,95 medidas mensais de RNI (RNI média: 2,60 ± 0,88, com 26,1% dos valores < 2 e 24,8% > 3), (mediana de TTR: 58%; IIQ: 47-68%), (TTR médio: 56,6% ± 18,9%). Apenas 31% dos pacientes estavam bem controlados (TTR médio: 78% ± 10%), com 1,6% apresentando grandes sangramentos na mediana do seguimento e custos médicos diretos por membro por ano (PMPY) de R$25.352 (± R$37.762). Pacientes com controle abaixo do ideal (69%) foram associados a 3,3 vezes mais sangramentos graves (5,3% vs. 1,6%; p <0,01) e custos 40% maiores (R$35.384 vs. R$25.352; p < 0,01). Conclusões: Mais de 60% dos pacientes estavam abaixo da meta desejada e os custos associados foram significativamente maiores nesta população.

Abstract Background: The safety and effectiveness of warfarin depend on anticoagulation control quality. Observational studies associate poor control with increased morbidity, mortality and healthcare costs. Objectives: To develop a profile of non-valvular atrial fibrillation (NVAF) patients treated with warfarin in a Brazilian private ambulatory and hospital setting, evaluate the quality of anticoagulation control, and its association with clinical and economic outcomes. Methods: This retrospective study, through a private health insurance dataset in Brazil, identified NVAF patients treated with warfarin between 01 MAY 2014 to 30 APRIL 2016, described their anticoagulation management, and quantified disease-related costs. Data on demographics, clinical history, concomitant medication and time in therapeutic range (TTR) of international normalized ratio (INR) values were retrieved. Patients were grouped into TTR quartiles, with good control defined as TTR ≥ 65% (Rosendaal method). Major bleeds and all-cause direct medical costs were calculated and compared between good and poor control subgroups. P-values < 0.05 were considered statistically significant. Results: The analysis included 1220 patients (median follow-up: 1.5 years; IQR: 0.5-2.0). On average, each patient received 0.95 monthly INR measurements (mean INR: 2.60 ± 0.88, with 26.1% of values < 2 and 24.8% > 3), (median TTR: 58%; IQR: 47-68%), (mean TTR: 56.6% ± 18.9%). Only 31% of patients were well-controlled (mean TTR: 78% ± 10%), with 1.6% having major bleeds within median follow-up, and direct medical costs per member per year (PMPY) of R$25,352(± R$ 37,762). Poorly controlled patients (69%) were associated with 3.3 times more major bleeds (5.3% vs. 1.6%; p < 0.01) and 40% higher costs (R$35,384 vs. R$25,352; p < 0.01). Conclusions: More than 60% of the patients were below the desired target and the associated costs were higher.

https://doi.org/10.36660/abc.20180076 1282 downloads

11.

First record of the Mediterranean mussel Mytilus galloprovincialis (Bivalvia, Mytilidae) in Brazil
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Belz, Carlos Eduardo

; Simone, Luiz Ricardo L.

; Silveira Júnior, Nelson

; Baggio, Rafael Antunes

; Gernet, Marcos de Vasconcellos

; Birckolz, Carlos João

Papéis Avulsos de Zoologia

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2020, Volume 60 elocation e20206007

Abstract: En | Text: En | PDF: En

Abstract The genus Mytilus comprises a large number of bivalve mollusk species distributed throughout the world and many of these species are considered invasive. In South America, many introductions of species of this genus have already taken place, including reports of hybridization between them. Now, the occurrence of the Mediterranean mussel Mytilus galloprovincialis is reported for the first time from the Brazilian coast. Several specimens of this mytilid were found in a shellfish growing areas in Florianópolis and Palhoça, Santa Catarina State, Brazil. Morphological analysis of the shells and molecular analysis through sequencing of the cytochrome oxidase subunit 1 (COI) confirmed the taxonomic identification. The species is known for its great invasive potential and can become a major environmental problem for seafood business and coastal communities, as it can compete and even hybridize with local species.

https://doi.org/10.11606/1807-0205/2020.60.07 977 downloads

12.

Cost Modifications during the Early Years of the Use of the National Cardiovascular Data Registry for Quality Improvement
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Barros, Pedro Gabriel Melo de

; Li, John

; Tremblay, Christine

; Okada, Mariana Yumi

; Sznejder, Henry

; Furlan, Valter

; Vasconcellos, Rafael

Clinics

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2020, Volume 75 elocation e1708

Abstract: En | Text: En | PDF: En

OBJECTIVES: Quality improvement (QI) initiatives based on data from international registries have been reported previously; however, there is a lack of information on the impact on the costs of medical care associated with the use of these tools. METHODS: Patients admitted due to myocardial infarction (MI), included in the ACTION Registry® and CathPCI Registry®, in a private Brazilian hospital (i.e., the reference hospital) were analyzed. The costs of care of these patients were compared to the costs of MI admissions in nine similar hospitals not included in the same QI program. Regression models were used to analyze the cost change over time between the two groups of hospitals. Readmission rates were compared using logistic regression, adjusting for the same variables as in the cost model. RESULTS: Overall, the annual medical cost inflation in Brazil was higher than the annual cost trend in the reference hospital during the period of analysis. Moreover, the annual in-hospital costs indicate that the reference hospital has a statistically significant 6% lower cost trend for patients with acute MI, compared to patients with the same diagnostic code in the comparison hospitals group, in an adjusted analysis (p-value=0.041). Using multivariable analysis, the readmission rates were also found to be significantly lower in the reference hospital than in the comparison hospitals, with an odds ratio of 0.68 (p-value=0.042). CONCLUSION: The use of the NCDR® as a benchmark to guide QI programs outside the United States was associated with the positive impact of bending the cost curve to below that of national medical inflation and the comparison hospitals’ costs, with a lower incidence of hospital readmission.

https://doi.org/10.6061/clinics/2020/e1708 108 downloads

13.

CONICITY AND YIELD FOR LUMBER FROM COMMERCIAL SPECIES FROM THE AMAZON
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Santos, Misael Freitas dos

; Gama, João Ricardo Vasconcellos

; Figueiredo Filho, Afonso

; Costa, Daniele Lima da

; Retslaff, Fabiane Aparecida de Souza

; Silva-Ribeiro, Renato Bezerra da

; Rode, Rafael

CERNE

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dec 2019, Volume 25 N. 4 Pages 439 - 450

Abstract: En | Text: En | PDF: En

ABSTRACT Stem conicity and the sawing pattern, besides the presence of hollows and sapwood, are among the principal factors that are responsible for the low yield of lumber from harvested wood in the Amazon. Therefore, the objective of this study was to analyze of logs and stem conicity, and its effect on yield of sawn wood from the species Handroanthus impetiginosus (Mart. ex DC.) Mattos, Lecythis lurida (Miers) S. A. Mori, Manilkara huberi (Ducke) Chevalier, Astronium lecointei Ducke and Couratari sp., which are currently the most important commercial species in the study area. The data used were obtained from six production units in the Tapajós National Forest, Pará. The variables analyzed were conicity (obtained as a function of the difference between diameters at the base and top) between logs, DBH classes (diameter at breast height) and species, as well as yield (estimated using the Software MaxiTora) between logs and species. The majority of the species showed differences in conicity between logs, with the first log being the most conic, which was directly reflected by the lower yield for this log. There was a tendency of increase in conicity in the larger DBH classes, and differences in conicity and yield between species. The estimated yields were superior to the percent yields observed for Amazonian species in studies done using samples with similar characteristics. Therefore, it was concluded that conicity can vary between species, logs, and DBH classes, and is a characteristic that directly effects the yield of lumber. Furthermore, the incorporation of cutting templates represents an alternative for maximizing lumber yield.

https://doi.org/10.1590/01047760201925042648 563 downloads

14.

O SISTEMA DE RANQUEAMENTO DO VOLEIBOL BRASILEIRO E SEUS DESDOBRAMENTOS
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Tavares, Marcelo Luis Ribeiro Silva

; Garcia, Rafael Marques

; Nascimento, Diego Ramos do

; Ribeiro, Carlos Henrique Vasconcellos

; Pereira, Erik Giuseppe Barbosa

Movimento

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2019, Volume 25 elocation e25054

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O objetivo deste artigo é analisar o sistema de ranqueamento do voleibol brasileiro e suas consequências na formação das equipes participantes. A metodologia é de natureza qualitativa, do tipo descritivo, utilizando como estratégia a análise documental. Os resultados exploram as justificativas para implantação do ranking dos atletas; o sistema de pontuação e suas consequências na composição das equipes; e as demandas recentes que têm feito a discussão ganhar contornos polêmicos. Conclui-se que o sistema vigente apresenta forte mecanismo restritivo na carreira de atletas nacionais e estrangeiros e somente com a constante atualização dos critérios atuais é que poderá se dinamizar os campeonatos nacionais formados por clubes e empresas dedicados ao esporte.

Abstract This article analyzes Brazilian volleyball’s ranking system and its impacts on the make-up of participating teams. Its methodology is qualitative, descriptive, using documentary analysis as its strategy. The results explore the reasons for implementing the athlete ranking; the scoring system and its consequences on the make-up of teams; and the recent demands that made the discussion controversial. It concludes that the current system is strongly restrictive for Brazilian and foreign athletes’ careers and only constant updating of the current criteria can dynamize Brazilian championships formed by clubs and companies dedicated to volleyball.

Resumen El objetivo de este artículo es analizar el sistema de ranking del voleibol brasileño y sus consecuencias en la formación de los equipos. La metodología es de naturaleza cualitativa, del tipo descriptivo, utilizando como estrategia el análisis documental. Los resultados exploran las justificaciones para la implantación del ranking de los atletas; el sistema de puntuación y sus consecuencias en la composición de los equipos; y las demandas recientes que han hecho que la discusión gane contornos polémicos. Se concluye que el sistema vigente presenta un fuerte mecanismo restrictivo en la carrera de atletas nacionales y extranjeros y solo con la constante actualización de los criterios actuales será posible dinamizar los campeonatos nacionales formados por clubes y empresas dedicados al deporte.

https://doi.org/10.22456/1982-8918.87657

15.

Nassarius foveolatus (Gastropoda, Nassariidae), a new record of an exotic species in Brazil
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Gernet, Marcos de Vasconcellos

; Belz, Carlos Eduardo

; Baggio, Rafael Antunes

; Birckolz, Carlos João

; Santos, Elizângela da Veiga

; Simone, Luiz Ricardo L.

; Abbate, Daniel

; Metri, Rafael

Papéis Avulsos de Zoologia

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2019, Volume 59 elocation e20195955

Abstract: En | Text: En | PDF: En

Abstract Exotic species are those that occur in an area beyond their natural limit and they are considered invasive when they cause harm to the economy, environment, or human health. In coastal environments, ballast water and inlays on the hull and other parts of vessels are the main ways of introducing invasive aquatic alien species. Nassarius foveolatus (Dunker, 1847) is native from the Central and East Indian Ocean to the East China Sea. The first specimens (empty shells) of N. foveolatus were collected manually on November 11, 2017 on the Rocio footbridge, located in the Paranaguá Estuarine Complex, on the coast of the State of Paraná, southern Brazil. Posteriorly, live specimens were collected in other localities of this bay. It is already possible to infer that the specimens of N. foveolatus occur together with the native specimens of N. vibex (Say, 1822), having the same niche. As previously only N. vibex existed in that place, at least a displacement of this native species has been occurred. However, certainly future ecological studies may confirm this displacement and additional consequences to the local ecosystem, as nassariids can be predators and scavengers. Control procedures should be also greatly implemented.

https://doi.org/10.11606/1807-0205/2019.59.55 465 downloads

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