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Treatment For Infected Frozen Elephant Trunk Prosthesis Caused by Propionibacterium acnes: A Surgical Challenge
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Barca, Laura Varela

; Esteban-Lucia, Laura

; Tomás-Mallebrera, Marta

; Pello-Lázaro, Ana

; Aldámiz-Echevarría, Gonzalo

Brazilian Journal of Cardiovascular Surgery

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2024, Volume 39 N. 1 elocation e20230186

Abstract: En | Text: En | PDF: En

ABSTRACT In this article, we present the case of a 47-year-old man who underwent Bentall-Bono procedure and frozen elephant trunk prosthesis implantation due to severe aortic regurgitation and aortic dilatation with a second-time endovascular stent-graft repair in descending aorta. Over eight years, a subacute graft infection by Propionibacterium acnes was developed, culminating in cardiogenic shock secondary to severe aortic regurgitation due to a complete aortic root dehiscence because of multiple aortic pseudoaneurysms. The patient underwent emergency surgery in which the replacement of the graft by a biological valve tube was performed accompanied by a complete debranching of the three supra-aortic vessels.

https://doi.org/10.21470/1678-9741-2023-0186

Comparación de dulzura en maíz elotero con diferente fondo genético e incorporación del gen shrunken2
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López-Hernández, Alexander

; Córdova-Téllez, Leobigildo

; Santacruz-Varela, Amalio

; García-Zavala, J. Jesús

Revista mexicana de ciencias agrícolas

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may 2023, Volume 14 N. 3 Pages 459 - 470

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La producción de elote superdulce en México se centra en el uso de híbridos comerciales, pues no existen razas nativas con esta característica, por esta razón se planteó la siguiente investigación con los objetivos: a) introducir un gen de dulzura en poblaciones nativas eloteras; y b) determinar su efecto sobre características agronómicas, calidad y aceptación por parte del consumidor. Se utilizaron las colectas nativas de maíz elotero: C-Pue-185 (Cacahuacintle), Hgo-428 (Chalqueño) y Hgo-416 (Elotes cónicos) infiltradas con el gen shrunken2 (sh2) y con diferentes proporciones de fondo genético de maíz nativo, como testigos se utilizaron los híbridos comerciales A7573, Cherokee y Sweeter93. Se establecieron experimentos en las localidades de Montecillo, Texcoco, Estado de México y San Felipe, Teotlalcingo, Puebla, en el año 2021, usando un diseño de bloques completos al azar con tres repeticiones. Se registraron características morfológicas, de rendimiento y una prueba sensorial. La población Hgo-428sh2F1 con fondo genético 50% nativo + 50% superdulce fue la mejor en cuanto a sólidos solubles totales (SST) con 16.5 ºBrix. En la prueba sensorial sobresalió la misma población Hgo-428sh2BC1F1, con fondo genético 75% nativo + 25% superdulce. Se identificó a la población formada por Hgo-428 (Chalqueño) como sobresaliente en sólidos solubles totales y sabor de elote. El híbrido comercial A7573 destacó en características morfológicas. Las poblaciones nativas originales Hgo-428 (Chalqueño) y C-Pue-185 (Cacahuacintle) fueron iguales al mejor testigo comercial A7573 en cuanto a rendimiento de grano fresco rebanado (RGFR). La incorporación del gen superdulce (sh2) afectó de manera negativa todas las características evaluadas.

Abstract The production of super sweet ear in Mexico focuses on the use of commercial hybrids, since there are no native races with this characteristic, for this reason the following research was proposed with the objectives: a) introduce a sweetness gene in native ear corn populations; and b) determine its effect on agronomic characteristics, quality and consumer acceptance. The following native collections of ear corn were used: C-Pue-185 (Cacahuacintle), Hgo-428 (Chalqueño) and Hgo-416 (Elotes Cónicos) infiltrated with the shrunken2 gene (sh2) and with different proportions of genetic background of native corn, the commercial hybrids A7573, Cherokee and Sweeter93 were used as controls. Experiments were established in the localities of Montecillo, Texcoco, State of Mexico and San Felipe, Teotlalcingo, Puebla, in 2021, using a randomized complete block design with three repetitions. Characteristics of morphology, of yield and a sensory test were recorded. The population Hgo-428sh2F1 with genetic background 50% native + 50% super sweet was the best in terms of total soluble solids (TSS) with 16.5 ºBrix. In the sensory test, the same population Hgo-428sh2BC1F1 stood out, with genetic background of 75% native + 25% super sweet. The population formed by Hgo-428 (Chalqueño) was identified as outstanding in total soluble solids and ear flavor. The commercial hybrid A7573 stood out in morphological characteristics. The original native populations Hgo-428 (Chalqueño) and C-Pue-185 (Cacahuacintle) were equal to the best commercial control A7573 in terms of sliced fresh grain yield (SFGY). The incorporation of the super sweet gene (sh2) negatively affected all the characteristics evaluated.

https://doi.org/10.29312/remexca.v14i3.3100

Early mobilization after total hip or knee arthroplasty: a substudy of the POWER.2 study
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Ripollés-Melchor, Javier

; Aldecoa, César

; Fernández-García, Raquel

; Varela-Durán, Marina

; Aracil-Escoda, Norma

; García-Rodríguez, Daniel

; Cabezudo-de-la-Muela, Lucia

; Hormaechea-Bolado, Lucía

; Nacarino-Alcorta, Beatriz

; Hoffmann, Rolf

; Lorente, Juan V.

; Ramírez-Rodríguez, José M.

; Abad-Motos, Ane

Brazilian Journal of Anesthesiology

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jan 2023, Volume 73 N. 1 Pages 54 - 71

Abstract: En | Text: En | PDF: En

Abstract Background Early mobilization after surgery is a cornerstone of the Enhanced Recovery After Surgery (ERAS) programs in total hip arthroplasty (THA) or total knee arthroplasty (TKA). Our goal was to determine the time to mobilization after this surgery and the factors associated with early mobilization. Methods This was a predefined substudy of the POWER.2 study, a prospective cohort study conducted in patients undergoing THA and TKA at 131 Spanish hospitals. The primary outcome was the time until mobilization after surgery as well as determining those perioperative factors associated with early mobilization after surgery. Results A total of 6093 patients were included. The median time to achieve mobilization after the end of the surgery was 24 hours [16-30]. 4,222 (69.3%) patients moved in ≤ 24 hours after surgery. Local anesthesia [OR = 0.80 (95% confidence interval [CI]: 0.72-0.90); p= 0.001], surgery performed in a self-declared ERAS center [OR = 0.57 (95% CI: 0.55-0.60); p< 0.001], mean adherence to ERAS items [OR = 0.93 (95% CI: 0.92-0.93); p< 0.001], and preoperative hemoglobin [OR = 0.97 (95% CI: 0.96-0.98); p< 0.001] were associated with shorter time to mobilization. Conclusions Most THA and TKA patients mobilize in the first postoperative day, early time to mobilization was associated with the compliance with ERAS protocols, preoperative hemoglobin, and local anesthesia, and with the absence of a urinary catheter, surgical drains, epidural analgesia, and postoperative complications. The perioperative elements that are associated with early mobilization are mostly modifiable, so there is room for improvement.

https://doi.org/10.1016/j.bjane.2021.05.008

Correlation between PET-CT and ct in the staging after the treatment of head and neck squamous cell carcinoma
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García-Curdi, Fernando

; Lois-Ortega, Yolanda

; Campo, Ana Muniesa-del

; McGee-Laso, Amaranta

; Sebastián-Cortés, José Miguel

; Vallés-Varela, Héctor

; Lambea-Sorrosal, Julio José

Brazilian Journal of Otorhinolaryngology

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dec 2022, Volume 88 Pages S143 - S151

Abstract: En | Text: En | PDF: En

Abstract Objective: The aim of this study is to find out if a single imaging test is enough to follow-up on an oncological post-treatment patient. In such a case, we would know which was more valuable after comparing the two, by CT or PET-CT. Methods: Between January 2012 and July 2018, we collected data from all patients with previous medical history who were treated with a head and neck squamous cell carcinoma in our hospital, through surgery or by using an organ preservation protocol which we had done. Patients were required to have a CT and a PET-CT performed in a maximum period of 30 days between techniques. We compared the post post-treatment stage given to each case by using only the physical examination (only the CT and the PET-CT), with the ones given by the Tumor Board. After treatment, we analysed the similarity through Cramer’s V statistic test. Results: We performed a comparative analysis, obtaining a correlation of 0.426 between the stages given by the Tumor Board and the one assigned based on physical examination, without imaging techniques. By only using the computed tomography as an imaging method the correlation was 0.565, whereas with only the use of positron emission computed technology, it was estimated at 0.858. When we compared the statistical association between stages using exclusively one of the two imaging techniques, the correlation was 0.451. Conclusion: Independent of the modality, we have demonstrated that in patients who have received previous treatment, there was a higher correlation in the stages with respect to the diagnostic method conducted by the Tumor Board using PET-CT as the sole image. Level of evidence: Level 1.

https://doi.org/10.1016/j.bjorl.2021.11.008

Violencia de pareja en adolescentes chilenos: Influencia del abuso infantil en la victimización y perpetración
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Sánchez, Paulina A.

; Reyes, Fernando T.

; Varela, Jorge J.

Revista médica de Chile

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jul 2022, Volume 150 N. 7 Pages 903 - 911

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Background: Childhood maltreatment extends beyond this stage of development, impacting adolescence and adulthood, and even adolescent dating violence. Adolescence is an essential transitional stage, so dating violence puts development at risk. In Chile, studies on adolescent dating violence are just emerging and still show a gap. Aim: To examine the relationship between abuse during childhood with victimization and perpetration experiences for adolescent dating violence. Material and Methods: The sample consisted of 242 adolescents between 14 and 19 years of age (59% females) who completed the Conflict in Adolescent Dating Relationship Inventory (CADRI) and the Childhood Trauma Questionnaire-Short Form (CQT-SF), both in their Spanish version. Multiple regression analysis was used to evaluate the degree of association between sexual, emotional, and physical abuse during childhood with adolescent dating violence. Results: Sexual and emotional abuse were predictors of dating victimization. In addition, sexual and physical abuse were found to be predictors of perpetration. Conclusions: Our study supports the evidence on differentiated outcomes between adolescent dating victimization and perpetration. Moreover, it highlights the role of childhood sexual abuse as a predictor of both.

https://doi.org/10.4067/s0034-98872022000700903

Characteristics of acute kidney injury in adult patients with severe COVID-19
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Contrera Rolón, Nicolás

; Varela, Carlos F

; Ferraris, Augusto

; Rojano, Adriana

; Carboni Bisso, Indalecio

; Greloni, Gustavo

; Bratti, Griselda I.

; San Román, Juan E.

; Heras, Marcos

; Las Sinner, Jorge F.

; Rosa Diez, Guillermo J.

Medicina (Buenos Aires)

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may 2022, Volume 82 N. 2 Pages 172 - 180

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Llevamos a cabo un estudio retrospectivo con el objetivo de describir las características clínicas, incidencia y desenlaces de los pacientes con injuria renal aguda (IRA) asociada a la COVID-19. Se incluyeron 162 pacientes con diagnóstico de COVID-19 admitidos en una unidad de cuidados intensivos en un hospital de tercer nivel en la Ciudad de Buenos Aires. Nuestra hipótesis consistió en que la IRA asociada a COVID-19 sería un evento temprano asociado a la gravedad de la hipoxemia y la IRA tardía se relacionaría con complicaciones propias de la UCI. Por ello se clasificó la IRA en temprana y tardía, según sucediera antes o después de los 14 días desde el inicio de síntomas. Se realizó un análisis multivariado mediante regresión logística escalonada para evaluar posibles factores de riesgo. La incidencia de IRA fue de 43.2% (n = 70), 11.1% (n = 18) requirieron terapia de reemplazo renal. La mortalidad intrahospitalaria fue mayor (58.6%) en el grupo con IRA. El diagnóstico de IRA se realizó en una mediana de 10 (IQR = 5.5-17.5) días desde el inicio de los síntomas. El antecedente de hipertensión e insuficiencia cardíaca, la edad y el requerimiento de ventilación mecánica invasiva (VMI) fueron identificados como factores de riesgo para IRA. La IRA tardía (n = 25, 35.7%) estuvo asociada a sepsis y expo sición a nefrotóxicos, mientras que la IRA temprana (n = 45, 64.2%) estuvo temporalmente asociada al inicio de la VMI y en muchos casos no se pudo filiar una etiología. En conclusión, la IRA es una complicación frecuente en pacientes con COVID-19 grave y está asociada a una alta mortalidad intrahospitalaria.

Abstract We conducted a retrospective cohort study to report the clinical characteristics, incidence and out-comes of patients with severe COVID-19 with acute kidney injury (AKI). One-hundred and sixtytwo intensive care unit (ICU) admitted patients in a tertiary level hospital in the city of Buenos Aires with COVID-19 diagnosis were included. We hypothesized that COVID-19 related AKI would develop in the period of more severe hypoxemia as an early event and late AKI would be more probably related to intensive care unit complications. For this purpose, we divided subjects into two groups: those with early AKI and late AKI, before and after day 14 from symptom onset, respectively. A stepwise multivariate analysis was conducted to find possible AKI predictors. AKI incidence was 43.2% (n = 70) of the total patients admitted into ICU with severe COVID-19, 11.1% (n = 18) required renal replacement therapy. In-hospital mortality was higher (58.6%) for the AKI group. AKI occurred on a median time of 10 (IQR 5.5-17.5) days from symptom onset. A history of hypertension or heart failure, age and invasive mechanical ventilation (IMV) requirement were identified as risk factors. Late AKI (n = 25, 35.7%) was associated with sepsis and nephrotoxic exposure, whereas early AKI occurred closer to the timing of IMV initiation and was more likely to have an unknown origin. In conclusion, AKI is frequent among critically ill patients with severe COVID-19 and it is associated with higher in-hospital mortality.

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Uso del pódcast como herramienta educativa en una residencia de Cirugía General en tiempos de COVID-19
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Petracchi, Enrique J.

; Quesada, Bernabé M.

; Coiz, Luciano

; Merchán del Hierro, Pablo A.

; Muthular, Magalí

; Mojsiejczuk, Matías D.

; Varela, José R.

; du Plessis, María C.

; Zaiacometti, Julieta A.

; Canullán, Carlos

Revista argentina de cirugía

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mar 2022, Volume 114 N. 1 Pages 36 - 43

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Background: COVID-19 pandemic altered the training of residents in surgery, reducing their opportunities to learn. Reading and analyzing scientific paper via podcasts could be an option to mitigate such problem. Objective: The aim of this study is to evaluate residents in surgery acceptance of the use of podcasts as a new educational tool. Material and methods: We conducted a longitudinal, analytical and exploratory study between May and December 2020. Each week, a resident was in charge of reading, analyzing and preparing a recorded presentation in the format of a podcast of an article selected by a staff physician. The residents’ experience was assessed by means of a Likert-type questionnaire designed by the investigators. Results: A total of 37 podcasts were recorded with a total number of plays of 2091. All the residents reported that this tool encouraged the academic peer discussion, 88% responded that it generated research questions and 43% agreed that listening to the podcasts served as inspiration to perform a bibliographic search. Conclusion: Reading and analyzing scientific papers via podcasts is well accepted and could be an additional tool for learning in atypical times.

RESUMEN Antecedentes: la pandemia de COVID-19 alteró la formación de los residentes de cirugía, disminuyendo sus oportunidades de aprendizaje. La lectura y análisis de trabajos científicos a través de pódcast podrían ser una opción para atenuar ese problema. Objetivo: evaluar la aceptación por parte de los residentes de Cirugía del uso de pódcast como una nueva herramienta educativa. Material y métodos: estudio exploratorio, analítico y longitudinal, realizado desde mayo hasta diciembre de 2020. Cada semana, un residente fue el encargado de leer, analizar y confeccionar una presentación grabada en forma de pódcast sobre un artículo seleccionado por médicos de planta. Se evaluó la experiencia de los residentes mediante un cuestionario tipo Likert diseñado por los investigadores. Resultados: se realizaron 37 pódcast, que se reprodujeron 2091 veces. El 100% de los residentes informó que esta herramienta fomentó la discusión académica entre pares, el 88% que le generó preguntas de investigación y el 43% que lo inspiró a una revisión bibliográfica. Conclusión: la lectura y análisis de trabajos a través de pódcast es bien aceptada y puede ser una herramienta adicional para el aprendizaje en épocas atípicas.

https://doi.org/10.25132/raac.v114.n1.1650 18 downloads

Applied Metaheuristic Optimization in Asphalt Pavement Management
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Vásquez-Varela, Luis R.

; García-Orozco, Francisco J.

Ciencia e Ingeniería Neogranadina

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dec 2021, Volume 31 N. 2 Pages 75 - 92

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: La Ingeniería de pavimentos es una encrucijada entre la Ingeniería geotécnica y la Ingeniería de transporte con una sólida base en los materiales de construcción. Existen diferentes aplicaciones de los algoritmos de optimización en la ingeniería de pavimentos, las cuales enfatizan la gestión del pavimento por sus implicaciones socioeconómicas y el cálculo inverso de las propiedades de las capas por su complejidad. Una revisión detallada de la literatura muestra que la optimización ha sido una preocupación permanente en la ingeniería de pavimentos; sin embargo, solo en las últimas dos décadas, el incremento del poder computacional permitió la implementación de técnicas de optimización metaheurísticas con resultados prometedores en la investigación y en la práctica. La gestión del pavimento requiere poderosas herramientas de optimización para problemas con objetivos múltiples, como minimizar costos y maximizar el estado del pavimento desde el nivel de la red hasta el del proyecto con presupuestos limitados. Una cantidad sustancial de investigaciones se centra en los algoritmos genéticos (AG), pero los nuevos desarrollos incluyen inteligencia de partículas (PSO, ACO y ABC). El estudio debe ir más allá de las redes de pequeño tamaño para mejorar la gestión de la infraestructura vial existente (pavimento, puentes) con base en criterios mecanicistas y de conflabllldad.

Abstract: Pavement engineering is a crossroads between geotechnical and transportation engineering with a sound base on construction materials. There are multiple applications of optimization algorithms in pavement engineering, emphasizing pavement management for its socioeconomic implications and back-calculation of layer properties for its complexity. A detailed literature review shows that optimization has been a permanent concern in pavement engineering. However, only in the last two decades, the increase in computational power allowed the implementation of metaheuristic optimization techniques with promising results in research and practice. Pavement management requires powerful optimization tools for multi-objective problems such as minimizing costs and maximizing the pavement state from network to project level with constrained budgets. A substantial amount of research focuses on genetic algorithms (GA), but new developments include particle intelligence (PSO, ACO, and ABC). The study must go beyond small-sized networks to improve the management of existing road infrastructure (pavement, bridges) based on mechanistic and reliability criteria.

https://doi.org/10.18359/rcin.4371 54 downloads

Adaptación y selección de maíces nativos en la región del Bajío de México por su caracterización morfológica
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Rangel-Lucio, J. Antonio

; Santacruz-Varela, Amalio

; Córdova-Téllez, Leobigildo

; García-Rodríguez, J. Guadalupe

; Cervantes-Ortíz, Francisco

; Vaquera-Huerta, Humberto

; Cuenca-Salgado, Jesús Alberto

Revista fitotecnia mexicana

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jun 2021, Volume 44 N. 2 Pages 241 - 250

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN La caracterización morfológica es un proceso de gran importancia para incorporar germoplasma de valor en los programas de introducción de maíz (Zea mays L.) con fines de mejoramiento genético. El objetivo del presente estudio fue caracterizar un grupo de 90 accesiones de 12 razas de maíz nativo de México: Bofo, Celaya, Coscomatepec, Elotes Occidentales, Harinoso de Ocho, Dulce de Jalisco, Mushito, Pepitilla, Serrano de Jalisco, Tablilla de Ocho, Tabloncillo y Zamorano Amarillo para identificar aquellas con mejores características productivas y de adaptación en el Bajío de México. Se utilizó un diseño de bloques completos al azar y se evaluaron caracteres agronómicos de la planta, espiga, mazorca y grano. Hubo diferencias significativas entre las accesiones de maíz nativo. El rendimiento de grano más alto se registró en las accesiones Gto-101 (8.3 t ha-1), Dgo-18 y Jal-554 de la raza Celaya y Jal-633 (6.0 t ha-1) de Elotes Occidentales. La mayor altura de planta y de mazorca y dimensiones de la espiga (longitud de pedúnculo, del tramo del eje con ramas y del eje principal) se prentaron en las accesiones Ver-406 (raza Coscomatepec), Nay-214 (Harinoso de Ocho), Dgo-218 (Celaya), y en Nay-191, Nay-196 y Nay-217 (Bofo). El análisis de conglomerados integró a las razas Bofo, Celaya y Elotes Occidentales en los Grupos I, II y III, mientras que el Grupo IV fue integrado por Mushito, Pepitilla, Bofo y Tabloncillo, y el Grupo V por mezclas de las razas evaluadas, excepto Celaya. Fue posible identificar accesiones de las razas de maíz Bofo, Celaya y Elotes Occidenatles prometedoras para el Bajío de México.

SUMMARY Morphological characterization is a process of great importance to incorporate valuable germplasm in the introduction programs of maize (Zea mays L.) for breeding purposes. The objective of this study was to characterize a group of 90 accessions of 12 maize races native to Mexico: Bofo, Celaya, Coscomatepec, Elotes Occidentales, Harinoso de Ocho, Dulce de Jalisco, Mushito, Pepitilla, Serrano de Jalisco, Tablilla de Ocho, Tabloncillo and Zamorano Amarillo to identify those with the best productive characteristics and adaptation to the Bajio region in Mexico. A randomized complete block design was used and agronomic traits of the plant, tassel, ear and grain were evaluated. There were significant differences between native maize accessions. The highest grain yield was registered in the accessions Gto-101 (8.3 t ha-1), Dgo-18 and Jal-554 of the Celaya race and Jal-633 (6.0 t ha-1) of Elotes Occidentales. The largest plant and ear height and tassel dimensions (length of the peduncle, of the branched section and the main axis) occurred in accessions Ver-406 (Coscomatepec race), Nay-214 (Harinoso de Ocho), Dgo-218 (Celaya), Nay-191, Nay-196 and Nay-217 (Bofo). The cluster analysis incorporated the Bofo, Celaya and Elotes Occidentales races into Groups I, II and III, while Group IV was integrated by Mushito, Pepitilla, Bofo and Tabloncillo, and Group V by mixture of the races evaluated, except Celaya. It was possible to identify promising accessions of Bofo, Celaya and Elotes Occidenatles maize races for the Mexican Bajio.

https://doi.org/10.35196/rfm.2021.2.241

10.

Somos más que testimonios, somos historiadoras encarnadas de la política interseccional e internacionalista: Entrevista con Suyapa Portillo Villeda
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Varela-Huerta, Amarela

; Abrego, Leisy J.

Andamios

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apr 2021, Volume 18 N. 45 Pages 273 - 305

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.29092/uacm.v18i45.819 89 downloads

11.

An overview of asphalt pavement design for streets and roads
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Vásquez-Varela, Luis R.

; García-Orozco, Francisco J.

Revista Facultad de Ingeniería Universidad de Antioquia

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mar 2021, N. 98 Pages 10 - 26

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Los pavimentos constituyen un problema geotécnico pues se construyen sobre el terreno con materiales obtenidos del mismo: no tratados, como suelos y rocas, y procesados como los aglomerantes hidráulicos y bituminosos; en consecuencia, el marco de referencia geotécnico es útil para describir sus elementos. El diseño de pavimentos asfálticos evolucionó de procedimientos empíricos a mecanicistas-empíricos (M-E) durante el siglo veinte. El método mecanicista-empírico, basado en la teoría de capas elásticas, se convirtió en una práctica con la publicación de los procedimientos de la Shell Oil, el Asphalt Institute y el LCPC, entre otros. Desde su origen, el procedimiento M-E consideró el diseño incremental del pavimento, sin embargo, solo hasta comienzos del siglo veintiuno se dispuso de la potencia computacional necesaria. La MEPDG representa el estado del arte del diseño incremental con avances e inconvenientes significativos, estos últimos relacionados con las actividades de calibración requeridas para el adecuado análisis y diseño según la subrasante, clima y materiales del sitio y para un nivel requerido de confiabilidad. Los pavimentos perpetuos son un subconjunto diseñado con el método M-E y con una trayectoria exitosa para las condiciones en las cuales son apropiados. Ningún método de diseño, desde la aproximación empírica más sencilla hasta el más complejo método mecanicista incremental, es adecuado sin un conocimiento satisfactorio de los factores de diseño y la calibración de los modelos de comportamiento para cada modo de daño.

ABSTRACT Pavements constitute a geotechnical problem since they are built on the ground and with materials obtained from it: untreated, such as soils and rocks, and processed as hydraulic and bituminous binders; consequently, a geotechnical framework is useful to describe their constitutive elements. The design of asphalt pavements for streets and roads evolved from empiric to mechanistic-empiric (M-E) procedures throughout the 20th century. The mechanistic-empiric method, based on layered elastic theory, became a common practice with the publication of separate procedures by Shell Oil, Asphalt Institute, and French LCPC, among others. Since its origin, the M-E procedure can consider incremental pavement design but, only until the beginning of the 21st century, the computational power became available to practicing engineers. American MEPDG represents the state-of-the-art M-E incremental design procedure with significant advantages and drawbacks, the latter mainly related to the extensive calibration activities required to assure a proper analysis and design according to subgrade, climate, and materials at a particular location and for an intended level of reliability. Perpetual pavements are a subset of M-E designed pavements with a proven history of success for the conditions where they are warranted. No design method, either the most straightforward empirical approach or the most elaborated incremental mechanistic one, is appropriate without proper knowledge about the fundamental design factors and calibration of the performance models for each distress mode upon consideration.

https://doi.org/10.17533/udea.redin.20200367 1259 downloads

12.

Consenso de hemofilia en México
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López-Arroyo, José L.

; Pérez-Zúñiga, Juan M.

; Merino-Pasaye, Laura E.

; Saavedra-González, Azucena

; Alcivar-Cedeño, Luisa María

; Álvarez-Vera, José Luis

; Anaya-Cuellar, Irene

; Arana-Luna, Luara L.

; Ávila-Castro, David

; Bates-Martín, Ramón A.

; Cesarman-Maus, Gabriela

; Chávez-Aguilar, Lénica A.

; Peña-Celaya, José A. de la

; Espitia-Ríos, María E.

; Estrada-Domínguez, Patricia

; Fermín-Caminero, Denisse

; Flores-Patricio, Willy

; García Chávez, Jaime

; García-Lee, María T.

; González-Pérez, María del Carmen

; González-Rubio, María del Carmen

; González-Villareal, María Guadalupe

; Ramírez-Moreno, Fabiola

; Hernández-Colin, Ana K.

; Hernández-Ruiz, Eleazar

; Herrera-Olivares, Wilfrido

; Leyto-Cruz, Faustino

; Loera-Fragoso, Sergio

; Martínez-Ríos, Annel

; Miranda-Madrazo, María R.

; Morales-Hernández, Alba

; Nava-Villegas, Lorena

; Orellana-Garibay, Juan J.

; Palma-Moreno, Orlando G.

; Paredes-Lozano, Eugenia P.

; Peña-Alcántara, Paula

; Pérez-Lozano, Uendy

; Pichardo-Cepín, Yayra M.

; Reynoso-Pérez, Ana Carolina

; Rodríguez-Serna, Mishel

; Rojas-Castillejos, Flavio

; Romero-Rodelo, Hilda

; Ruíz-Contreras, Josué I.

; Segura-García, Adela

; Silva-Vera, Karina

; Soto-Cisneros, Paulina M.

; Tapia-Enríquez, Ana L.

; Tavera-Rodríguez, Martha G.

; Teomitzi-Sánchez, Óscar

; Tepepa-Flores, Fredy

; Valencia-Rivas, María D.

; Valle-Cárdenas, Teresa

; Varela-Constantino, Ana

; Javier-Morales, Adrián

; Martínez-Ramírez, Mario A.

; Tena-Cano, Sergio

; Terrazas-Marín, Ricardo

; Vilchis-González, Shendel P.

; Villela-Peña, Atenas

; Mena-Zepeda, Verónica

; Alvarado Ibarra, Martha

Gaceta médica de México

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2021, Volume 157 Suppl. 1 Pages S1 - S37

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles and elbows). This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion transmitted infections) or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology charachterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia.

resumen está disponible en el texto completo

https://doi.org/10.24875/gmm.m20000451 305 downloads

13.

Frequency, territorial distribution and antimicrobial resistance of Salmonella spp. on bovine cattle feces from the Altos Sur region of Jalisco State, Mexico
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Navarro-Villarruel, Claudia Luz

; Ibarra-Velázquez, Luz María

; Diosdado-Rojas, Joel David

; Madriz-Elisondo, Ana Luisa

; Cardona-López, Marco Antonio

; Varela-Hernández, Juan José

; Silva-Sánchez, Jesús

; Arvizu-Medrano, Sofía María

; Padilla-Frausto, J. Jesús

Biotecnia

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2021, Volume 23 N. 3 Pages 5 - 13

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Multidrug resistance is a global public health problem. In 2017, in Mexico, Salmonella caused 192,771 food-borne zoonosis cases. Sonora, Hidalgo, Mexico State and Jalisco have reports of multi-resistant Salmonella strains in chicken and beef carcasses in slaughterhouses; however, the prevalence in livestock herds is unknown. From January 2012 to October 2013, 144 diarrheal stool samples were collected from bovine hatchlings from the Altos Sur region of the Jalisco State. As a result, the presence and serotype of Salmonella was determined, as well as the antibiotic resistance profile, and the genetic relationship, using PFGE. The Salmonella prevalence was 4.16 % (6/144) in feces, identifying the serotypes Anatum, Pullorum, Poona, Typhi, Gallinarum and Salmonella enterica subsp. arizonae. All the strains showed resistance to ampicillin, cephalothin, trimethoprim-sulfamethoxazole, and some of them, additionally, to amikacin, cefotaxime and/or ceftriaxone. In addition, the persistence and potential spread of two Salmonella Anatum strains was discovered in one herd. This is the first study conducted in neonate bovine in the Jalisco State, Mexico, to detect multidrug resistant Salmonella. Continuous monitoring of multi-drug resistance in animal biota for human food and ongoing training of veterinary doctors are key elements for efficient prophylaxis and antimicrobial pharmacotherapy.

Resumen La multifarmacorresistencia es un problema mundial de salud pública. En el 2017, en México, Salmonella causó 192,771 casos de zoonosis de origen alimentario. Sonora, Hidalgo, Estado de México y Jalisco tienen reportes de Salmonella multirresistente en canales de pollo y res en mataderos. Sin embargo, se desconoce la prevalencia en animales en hatos ganaderos. De enero-2012 a octubre-2013 se recolectaron 144 muestras de heces diarreicas de neonatos bovinos de la región Altos Sur del estado de Jalisco. Se determinaron los serotipos de Salmonella, el perfil de multifarmacorresistencia y el genotipo mediante PFGE. Se encontró una prevalencia del 4.16% (6/144) de Salmonella en heces, recuperándose los serotipos Anatum, Pullorum, Poona, Typhi, Gallinarum y Salmonella enterica subsp. arizonae. Todas las cepas mostraron resistencia a ampicilina, cefalotina, trimetoprim-sulfametoxazol y adicionalmente algunas a amikacina, cefotaxima y/o ceftriaxona. Se descubrió una persistencia y propagación de dos cepas de Salmonella Anatum en un hato. Este es el primer estudio realizado en bovinos recién nacidos en el estado de Jalisco, México, para la detección de Salmonella multirresistente. Es necesario el monitoreo continuo de la multi-farmacorresistencia en la biota de animales para alimento humano y una capacitación continua de médicos veterinarios para una eficiente profilaxis y farmacoterapia antimicrobiana.

https://doi.org/10.18633/biotecnia.v23i3.1371 17 downloads

14.

Protein profile as a quality indicator of cryopreserved semen from Tambaqui Colossoma macropomum (Cuvier, 1818)
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Galo, J. M.

; Streit-Jr, D. P.

; Corcini, C. D.

; Varela-Jr, A. S.

; Jardim, R. D.

; Ribeiro, R. P.

Brazilian Journal of Biology

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dec 2020, Volume 80 N. 4 Pages 752 - 762

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo desse estudo foi de avaliar a associação entre a presença de proteínas no plasma seminal do tambaqui Colossoma macropomum (Cuvier, 1818) com indicadores de qualidade seminal pós-descongelamento. O semen foi criopreservado com diluidor a base de BTS com 8% DMSO. Uma amostra de 200 µL de semen de cada animal foi diluída em 800 µL de BTS, e centrifugada em 800 rpm, e somente o sobrenadante foi criopreservado para posterior análise do perfil proteico do plasma seminal, através da eletroforese unidimensional (SDS-PAGE). Decorridos 15 dias da criopreservação, uma palheta com semen criopreservado foi descongelado para análise dos parâmetros quali-quantitativos. Considerando todas as coletas, o SDS-PAGE identificou 15 bandas proteicas no plasma seminal do tambaqui. Quando se avaliou a interação (presença ou ausência) das proteínas encontradas no plasma seminal, com os parâmetros espermáticos pós-descongelamento, observou-se grande influência da presença das proteínas na qualidade espermática. Observou-se maior taxa de fertilização (P<0,05) com a presença das proteínas 12, 34, 44, 85 e 90 kDa. As proteínas do plasma seminal de tambaqui influenciaram na qualidade espermática após descongelamento, podendo ser utilizadas como indicadores para a qualidade espermática após descongelamento, principalmente as proteínas com peso molecular ≤50 kDa.

Abstract The aim of this study was to evaluate the association between proteins in the seminal plasma of tambaqui Colossoma macropomum (Cuvier, 1818) with seminal quality indicators after thawing. The semen was cryopreserved with a dilution based on BTS with 8% DMSO. A 200 µL sample of semen from each animal was diluted in 800 µL BTS, centrifuged at 800 rpm, and the supernatant was cryopreserved to further analyze of the protein profile of seminal plasma through one-dimensional electrophoresis (SDS-PAGE). After 15 days of cryopreservation, a cryopreserved semen straw was thawed to analyze both qualitative and quantitative parameters. When considering all collections, the SDS-PAGE identified 15 protein bands in the seminal plasma of tambaqui. When the interaction (presence or absence) between proteins observed in the seminal plasma and the post thawed spermatic parameters was evaluated, we observed a great influence of the presence of proteins on spermatic quality. A greater (P<0.05) fertilization rate was observed with the presence of proteins 12, 34, 44, 85, and 90 kDa. Proteins in seminal plasma of tambaqui influenced the spermatic quality after thawing, and thus, they can be utilized as an indicator of sperm quality, especially the proteins with a molecular weight ≤ 50 kDa.

https://doi.org/10.1590/1519-6984.219140 416 downloads

15.

La Percepción de Apego con la Escuela Como un Factor Protector Para Conductas Antisociales en Escolares Chilenos
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Varela, Jorge J.

; Torres-Vallejos, Javier

; González, Constanza

; García, Oriana

Psykhe (Santiago)

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dec 2020, Volume 29 N. 2 Pages 1 - 12

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: Schools can be regarded as vital spaces for human development and even as factors that protect adolescents from developing risk behaviors. The present study sought to examine the perception of greater school attachment as a protective factor against peer influence in antisocial behaviors in the Chilean context. A stratified sample was used, with an equal allocation of 815 students from 7th to 12th grade enrolled in 15 schools belonging to 5 SES categories, selected randomly in the Metropolitan Region (46.6% female, with an average age of 15.11 years; SD = 1.78). An adaptation of the Communities That Care Youth Survey was used to analyze reports of antisocial behaviors at school, relationships with antisocial peers, drug use by peers, and attachment to school. A multiple regression analysis revealed an interaction effect: for students who perceive more attachment to their school, the influence of peers with antisocial behaviors is moderated relative to those with a perception of low school attachment. This result provides evidence of the importance of school attachment in preventing antisocial behaviors in adolescents and informing prevention programs in school contexts.

Resumen: La escuela puede ser considerada un espacio vital de desarrollo humano e incluso un factor protector para el desarrollo de conductas de riesgo en adolescentes. El presente estudio buscó examinar la percepción de un mayor apego escolar como un factor protector de la influencia de pares en conductas antisociales en el contexto chileno. Se usó una muestra estratificada con afijación igual de 815 escolares de 7° año básico a IV año medio provenientes de 15 establecimientos escolares seleccionados aleatoriamente de 5 diferentes NSE de la Región Metropolitana, 46,6% mujeres, con una edad promedio de 15,11 años DE = 1,78). Se utilizó una adaptación del instrumento Communities That Care Youth Survey, analizando el reporte de conductas antisociales en la escuela, relación con pares antisociales, consumo de drogas por parte de pares y apego con la escuela. Por medio de un análisis de regresión múltiple, se evidenció un efecto de interacción, en donde para aquellos estudiantes que perciben un mayor apego con la escuela, la influencia de los pares con conductas antisociales se ve moderada, en comparación con los estudiantes que tienen una percepción de bajo apego con la escuela. Este resultado provee evidencia sobre la importancia del apego con la escuela para prevenir conductas antisociales en adolescentes y para informar programas de prevención en contextos escolares.

https://doi.org/10.7764/psykhe.29.2.1416 722 downloads

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