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ABSTRACT. Sea cucumbers (holothuroids) play a major role in coastal environments; their detritivore conduct favors oxygen penetration in the sediments and the disposal of pathogens on the sea floor. This study determined holothuroid diversity in the rocky intertidal zone of Matanchén Bay, Mexico. Sampling campaigns were carried out in January, March, May, and July 2018. Linear transects (10 m length and 1 m width) perpendicular to the coastline in rocky areas (0-3 m depth) were established, where the density (ind m-2) and proportion (%) of sea cucumbers were estimated. Organisms were photographed, examined live, and preserved in 70% alcohol for subsequent identification utilizing ossicle characterization. Our results show the presence of four sea cucumber species: Holothuria (Halodeima) inornataSemper, 1868, Holothuria (Selenkothuria) lubricaSelenka, 1867, Holothuria (Selenkothuria) portovallartensisCaso, 1954, and Holothuria (Mertensiothuria) viridiaurantiaBorrero-Pérez & Vanegas-González, 2019. The average density per species was 0.208, 0.108, 0.017, and 0.025 ind m-2, respectively; each species' proportion was 58.1, 30.2, 4.7, and 7.0%, respectively. Due to the above values, we found that the number and spatial distribution of sea cucumber species vary in Matanchén Bay.

https://doi.org/10.3856/vol50-issue5-fulltext-2881

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Publication date: 2022-10-11

Abstract: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

Bell pepper rootstocks with multiple resistance to soilborne diseases
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Ragassi, Carlos Francisco

; Ribeiro, Cláudia Silva da Costa

; Patiño-Torres, Albania

; Lopes, Carlos Alberto

; Pinheiro, Jadir Borges

; Reis, Ailton

Revista Ceres

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may 2022, Volume 69 N. 3 Pages 299 - 307

Abstract: En | Text: En | PDF: En

ABSTRACT Grafting has been increasingly used to overcome soilborne pathogens. The commercial rootstock hybrids AF-8253 (Sakata) and Fortaleza (Takii), as well as Embrapa’s new hybrid, BRS Acará, were evaluated as rootstocks for the bell pepper hybrids Margarita (Syngenta) and Pampa (Clause) as scions, under natural infestation of Ralstonia pseudosolanacearum, as well as upon artificial inoculation with a) ten Ralstonia isolates, b) one Phytophthora capsici isolate, c) Meloidogyne incognita race 1, and d) Meloidogyne enterolobii (only rootstocks for c and d). Grafted bell peppers consistently showcased a higher productivity than did non-grafted ones under natural R. pseudosolanacearum infestation, and the rootstock genotype affected fruit size distribution. Rootstocks presented higher resistance than did commercial bell pepper hybrids (scions) for 6 out of 10 Ralstonia isolates. AF-8253 and BRS Acará displayed an immune-like response to P. capsici, while Fortaleza was moderately resistant (25% symptomatic plants) and the bell pepper hybrids (scions) were susceptible (100% symptomatic plants). Rootstocks were immune to M. incognita race 1, but slightly (AF-8253 and BRS Acará) or moderately (Fortaleza) resistant to M. enterolobii. Grafting with BRS Acará, as well as with AF-8253 or Fortaleza, is recommended for managing bacterial wilt, Phytophthora blight, and root-knot nematodes.

https://doi.org/10.1590/0034-737x202269030007

Confirmed presence of the Neotropical otter, Lontra longicaudis, in Laguna Bacalar, Quintana Roo, Mexico
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Corona-Figueroa, Mildred Fabiola

; Giraldo-Mueses, John Alexander

; Cedeño-Vázquez, José Rogelio

; Castelblanco-Martínez, Delma Nataly

; Niño-Torres, Carlos Alberto

; Beutelspacher-García, Pablo M.

; Ibarra-Madrigal, Silvana Marisa

; Pérez-Flores, Jonathan

Revista mexicana de biodiversidad

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2022, Volume 93 elocation e933847

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La nutria neotropical Lontra longicaudis es uno de los mamíferos menos estudiados en la península de Yucatán y su presencia en algunos cuerpos de agua de esta región es cuestionable. La laguna de Bacalar es el mayor cuerpo de agua dulce de la península de Yucatán y enfrenta varios problemas de conservación debido a su alto potencial de desarrollo turístico. Confirmamos la presencia de L. longicaudis en la laguna de Bacalar mediante entrevistas con los residentes locales y la búsqueda de evidencias directas (avistamientos) e indirectas (p. ej. huellas) de presencia de la especie en 2013. Incluimos observaciones directas recientes (2019-2020). Clasificamos la información por niveles de certeza, según el tipo de evidencia que la respalda (fotografías, videos). Obtuvimos 9 registros de nutria neotropical a través de entrevistas (nivel 3); 3 avistamientos y 4 huellas (nivel 1), y 4 avistamientos (3 con nivel 2 y 1 con nivel 3 de certeza). Es necesario incrementar los esfuerzos de investigación para determinar el estado de conservación y la distribución de la nutria neotropical en la laguna. Recomendamos realizar esfuerzos en cuanto a la socialización y a la educación para facilitar la conservación de esta especie y su hábitat en la laguna de Bacalar.

Abstract The Neotropical otter Lontra longicaudis is one of the least studied mammals of the Yucatán Peninsula and its presence in some water bodies of this region is questionable. Laguna Bacalar is the largest freshwater body located in the Yucatán Peninsula and faces several conservation problems due to its high potential for tourism development. We confirmed the presence of L. longicaudis in Laguna Bacalar by conducting interviews with residents, and the search for direct (sightings) and indirect (e.g., footprints) evidence of the species in 2013. We also include recent direct and indirect evidence (2019-2020). We classified the records into levels of certainty, according to the type of evidence (photographs, videos). We obtained 9 records of Neotropical otter through interviews (level 3), 3 sightings and 4 footprints (level 1), and 4 sightings (3 of these with level 2 and 1 with level 3 of certainty). It is necessary to increase the research effort to determine the conservation status and distribution of the Neotropical otter in the lagoon. We recommend making efforts in terms of socialization and education to facilitate the conservation of the Neotropical otters and their habitat in Laguna Bacalar.

https://doi.org/10.22201/ib.20078706e.2022.93.3847

La inversión en marcas y su relación con los resultados empresariales
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Cardozo-Torres, Valentina

; Méndez-Morales, Alberto

; Herrera, Milton M.

Suma de Negocios

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dec 2021, Volume 12 N. 27 Pages 161 - 171

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Las marcas son un activo intangible con un alto valor estratégico para las organizaciones. Si bien las marcas influyen en el mercado, la relación entre la inversión en dichos activos y los impactos financieros en las firmas aun no es muy clara. En este artículo se busca entender la forma en que la creación, la adecuada gestión y la promoción de las marcas, como activos intangibles, afectan los resultados financieros de las empresas, de igual forma, nos preguntamos cuáles variables median en dicha relación. El artículo presenta una revisión sistemática de la literatura de los estudios relacionados con la inversión en marcas y su impacto en el desempeño organizacional, que fueron llevados a cabo entre 2016 y 2020. Los resultados muestran que los estudios refieren relaciones de dos niveles entre las marcas y los resultados empresariales, que las mismas usan datos de encuestas de percepción y de bases de datos de terceros y que, generalmente, estos estudios se han realizado para los países en vía de desarrollo. Esta revisión contribuye con una mirada de futuras direcciones de investigación en relación con la inversión en activos intangibles y el desempeño organizacional

Abstract Brands are an intangible asset with high strategic value for organizations. Although brands influence the market, the relationship between investment in these assets and the financial impact on firms is still not very clear. This article aims to understand the way in which the creation, management, and promotion of brands, as intangible assets, have on financial performance of firms, in the same direction, we wonder which are the variables mediating on that relationship. The paper presents a systematic review of the literature of the studies brought related to investment in brands and its impact on organizational performance between 2016 and 2020. The results show the studies refer to two-level relationships between brands and business results, that they use data from perception surveys and third-party databases, and that it has carried these studies out for developing countries. This review contributes with a look at future research directions in relation to investment in intangible assets and organizational performance.

https://doi.org/10.14349/sumneg/2021.v12.n27.a07 93 downloads

La coexistencia de Desmodus rotundus con la población humana en San Luis Potosí, México
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Torres-Mejía, Ximena

; Pérez-Rivero, Juan José

; Olvera-Vargas, Luis Alberto

; Barragán-Hernández, Evaristo Álvaro

; Martínez-Maya, José Juan

; Aguilar-Setién, Álvaro

Revista mexicana de ciencias pecuarias

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sep 2021, Volume 12 N. 3 Pages 694 - 704

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Desmodus rotundus is a transmitter of zoonotic and emerging diseases to humans and livestock, such as rabies. Most infectious diseases are spatially limited by the presence of the transmitter, whose abundance and survival are influenced by environmental conditions and the presence of food sources. A tool that facilitates its study is the use of Geographic Information Systems. The objective of this study was to analyze the interaction of populations of hematophagous bats and humans, through the development of a probable model of dispersal of D. rotundus based on known shelters and different environmental variables, in addition to analyzing the relationship between shelters identified for three years and their proximity to human settlements, as a process of coexistence. The study was conducted in the state of San Luis Potosí from 2014 to 2016. A total of 180 shelters of D. rotundus distributed towards the Huasteca region were identified, 80 % of these were built by man and 57 % were inhabited. A buffer of 5 km around from the location of each shelter was calculated, finding inside a total of 976 rural communities and 15 cities, with 337,836 inhabitants. The average distance from shelters to the first human settlement was 518.65 ± 11.33 m. It is necessary to continue studying the association between urbanization and the emergence of zoonoses, through the understanding of the interactions between wild animals-livestock-humans.

Resumen Desmodus rotundus es transmisor de enfermedades zoonóticas y emergentes a los humanos y al ganado, como el caso de la rabia. La mayoría de las enfermedades infecciosas están limitadas espacialmente por la presencia del transmisor, cuya abundancia y supervivencia son influenciadas por las condiciones ambientales y la presencia de fuentes de alimentación. Una herramienta que facilita su estudio es el uso de los Sistemas de Información Geográfica. El objetivo de este estudio fue analizar la interacción de las poblaciones de murciélagos hematófagos y humanos, a través de la elaboración de un modelo probable de dispersión del D. rotundus basado en refugios conocidos y diferentes variables medioambientales, además de analizar la relación entre refugios identificados durante tres años y su cercanía con asentamientos humanos, como un proceso de coexistencia. El estudio se llevó a cabo en el estado de San Luis Potosí del año 2014 al 2016. Se identificaron un total de 180 refugios de D. rotundus distribuidos hacia la zona de la Huasteca, el 80 % de éstos fueron construidos por el hombre y el 57 % se encontraron habitados. Se calculó un buffer de 5 km a la redonda a partir de la ubicación de cada refugio, encontrando en su interior un total de 976 comunidades rurales y 15 ciudades, con 337,836 habitantes. La distancia media de los refugios hasta el primer asentamiento humano fue de 518.65 ± 11.33 m. Es necesario continuar estudiando la asociación entre la urbanización y el surgimiento de zoonosis, a través del entendimiento de las interacciones entre animales silvestres-ganadería - humanos.

https://doi.org/10.22319/rmcp.v12i3.5670 74 downloads

The first Peruvian record of Enchodus (Actinopterygii, Aulopiformes, Enchodontidae) in the Upper Cretaceous Vivian Formation
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Gouiric-Cavalli, Soledad

; Cione, Alberto L.

; Tineo, David E.

; Pérez, Leandro M.

; Iribarne, Martín

; Allcca-Torres, Miguel A.

; Poiré, Daniel G.

Andean geology

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may 2021, Volume 48 N. 2 Pages 303 - 315

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT We describe isolated teleostean teeth found in no association with the jaw bone. The specimens have been recovered in Late Cretaceous marine deposits of the Vivian Formation in the Peruvian Sub-Andean Region. The deposition sequence from where the teeth come is interpreted as a shallowing-upward sequence of low salinity. The fish material is identified as Enchodus aff. E. gladiolus based on the presence of a small but well-developed post-apical barb, an anterior cutting edge, the crown is symmetrical in cross-section, have a sigmoidal profile, and bears strong ridges (=striations). The Peruvian material differs from the typical E. gladiolus teeth in having a faintly serrated anterior cutting edge which is absent in most specimens referred to E. gladiolus. We also highlight that taxonomic assignments made based on isolated teeth must be taken with care. Despite scarce, the material recovered denotes that the marine units of Peru can give valuable information about the Pacific fish fauna during the Late Cretaceous.

RESUMEN Se describen dientes aislados de peces teleósteos, los que no se encontraron asociados con huesos de las quijadas Los especímenes han sido recuperados en depósitos marinos del Cretácico tardío de la Formación Vivian en la Región Subandina del Perú. La secuencia sedimentaria de donde provienen los dientes se interpreta como una secuencia somerizante de baja salinidad. El material de peces es referido como Enchodus aff. E. gladiolus con base en la presencia de una barba posapical pequeña, pero bien desarrollada, además de un borde cortante anterior; la corona es simétrica en sección transversal, con un perfil sigmoidal y fuertes crestas (=estrías). El material peruano se diferencia de los dientes típicos de E. gladiolus en tener un borde cortante anterior ligeramente aserrado que está ausente en la mayoría de los especímenes referidos a E. gladiolus. Se destaca también que las asignaciones taxonómicas realizadas a partir de dientes aislados se deben tomar con cuidado. A pesar de ser escaso, el material recuperado denota que las unidades marinas del Perú pueden brindar información valiosa sobre la fauna de peces del Pacífico durante el Cretácico Superior.

https://doi.org/10.5027/andgeov48n2-3337 225 downloads

Análisis de QTL asociados a polimorfismos de nucleótido único (SNP) involucrados en el fenotipo lechero del ganado Holstein
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Valdez-Torres, Jose Manuel

; Grado Ahuir, Juan Alberto

; Castro-Valenzuela, Beatriz Elena

; Burrola-Barraza, M. Eduviges

Revista mexicana de ciencias pecuarias

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dec 2020, Volume 11 N. 4 Pages 1192 - 1207

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The aim was to identify QTLs associated with single nucleotide polymorphisms (SNPs) whose action contributes to the productive, reproductive and health phenotypic development of Holstein dairy cattle. 341 QTLs located in 120 genes of the Bos taurus UMD_3.1.1 genome and associated with 189 SNPs with effects on productive (FY, NM, MY, MTCAS, MBLF and PL), reproductive (CONCRATE, DPR, EMBSUR, DAYOPEN and CONCEPT) and health traits (SCC, BTBS and RESRATE) were identified. SNPs were verified in the dbSNP-NCBI database, according to which 42 % were located in introns. The Jvenn platform revealed that the SNPs rs135744058, rs110828053 and rs109503725 were common in all three traits. The network of correlations between traits and genes generated by MetScape (Cytoscape 3.4), showed a positive correlation between PL, DPR, DAYOPEN, CONCRATE and CONCEPT, and a negative correlation of FY with PL, NM, DPR and CONCRATE. The functionality of each gene was validated in the Gene-NCBI and UniProt databases, and ClueGo (Cytoscape 3.4) was used to select functional pathways with a significance value less than 0.05, which rendered an intertwining between the development of the mammary gland, the activation of the immune system and the response to steroid hormones evident, the GH gene being the one that directs this functionality. Although the genetic panorama shows that there is an antagonism between productive and reproductive traits, the functional genetic activity due to the 189 SNPs analyzed exhibits an interwoven action in ontological pathways that influence the production processes, as well as in reproductive and health pathways.

Resumen El objetivo fue identificar QTL asociados a polimorfismos de nucleótido único (SNP) cuya acción contribuya al desarrollo fenotípico productivo, reproductivo y de salud del ganado lechero de raza Holstein. Ubicados en 120 genes del genoma Bos taurus UMD_3.1.1, se identificaron 341 QTL asociados a 189 SNP con efectos sobre rasgos productivos (FY, NM, MY, MTCAS, MBLF y PL), reproductivos (CONCRATE, DPR, EMBSUR, DAYOPEN y CONCEPT) y de salud (SCC, BTBS y RESRATE). Los SNP fueron verificados en la base de datos dbSNP-NCBI donde 42 % se ubicaron en intrones. Con la plataforma Jvenn se supo que los SNP rs135744058, rs110828053 y rs109503725, fueron comunes en los tres rasgos. La red de correlaciones entre rasgos y genes generada por MetScape (Cytoscape 3.4), mostró una correlación positiva entre PL, DPR, DAYOPEN, CONCRATE y CONCEPT; y una negativa de FY hacia PL, NM, DPR y CONCRATE. La funcionalidad de cada gen fue validada en las bases Gene-NCBI y UniProt, y por ClueGo (Cytoscape 3.4) se seleccionaron vías funcionales con un valor de significancia menor a 0.05, lo que evidenció un entrelazamiento entre el desarrollo de la glándula mamaria, la activación del sistema inmune y la respuesta a hormonas esteroideas; siendo el gen GH quien dirige dicha funcionalidad. Aunque el panorama genético muestra que existe un antagonismo entre rasgos productivos y reproductivos, la actividad genética funcional debido a los 189 SNP analizados, muestra una acción entrelazada en vías ontológicas que influyen tanto en los procesos de producción, así como en vías de reproductivas y de salud.

https://doi.org/10.22319/rmcp.v11i4.5295 441 downloads

10.

Reflexión bioética interdisciplinaria en torno a la edición genética con CRISPR-Cas en línea germinal en el contexto del transhumanismo
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Casas Martínez, Ma. de la Luz

; Aspe Armella, Virginia

; Derive, Stéphanie

; González-del-Rincón, M. Lourdes

; Ibarra Soto, Diana

; Ramírez García, Hugo S.

; Ross, Alberto

; Ruiz-Gómez, Leonardo

; Torres Añorve, Victoria A.

Revista de filosofía open insight

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apr 2019, Volume 10 N. 18 Pages 185 - 213

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The purpose of this article is to explain some of the implications of using the CRISPR-Cas technique in the germinal line for non-therapeutic purposes, in the context of transhumanism. After giving a brief explanation about the nature of this technique, the state of the question is offered in relation to the current international regulations. Afterwards, the consequences of the development of this technique within the framework of the transhumanism project are observed and it offers legal, political and anthropologi- cal reflections on these consequences.

Resumen El propósito de este trabajo es explicar algunas de las implicaciones que conlleva la utilización de la técnica CRISPR-Cas en línea germinal con fines no terapéuticos, en el contexto del transhumanismo. Después de dar una breve explicación sobre la naturaleza de esta técnica, se ofrece el estado de la cuestión en lo referente a la normativa internacional vigente. Posteriormente, se observan las consecuencias que tiene el desarrollo de esta técnica en el marco del proyecto transhumanista y se ofrece una reflexión jurídica, una política y una antropológica sobre las mismas.

https://doi.org/10.23924/oi.v10n18a2019.pp25p.326

11.

Effect of the Erbium Concentration in the Luminescent Properties of ZrO2
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Ojeda M., M.

; Rentería, V.

; Sánchez-Mondragón, J. J.

; May-Arrioja, D. Alberto

; Torres-Cisneros, M.

; Ojeda M., M. L.

; Velásquez, C.

Computación y Sistemas

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mar 2019, Volume 23 N. 1 Pages 21 - 25

Abstract: En | Text: En | PDF: En

Abstract: In this work, an analysis of the luminescent properties of zirconium oxide (ZrO2) doped with Er3+ in three different concentrations was performed to investigate which sample could be useful for optoelectronic applications. To achieve it, a set of four samples of ZrO2:Er3+ with the variation in Er3+ concentration about 0%, 0.1%, 0.2% y 0.3% were synthesized by the sol-gel method. The luminescence measurements for all samples were performed using an excitation wavelength of 380 nm, by this way the upconversion spectrum for the sample containing the 0.2% of Er3+ was measured at 980 nm. The luminescence spectra showed three emission bands attributed to the electronic transitions 4F7/2→4I15/2, 2H11/2→4I15/2, and 2S3/2→4I15/2, all this band belonged to Er3+ radiative transitions, we found that the sample with 0.2% presented a higher emission intensity at 550 nm compared with the others samples, also the average lifetime was calculated, we found that this value decrease with the increment of Er3+ concentration, finally, the upconversion spectrum were measured for the sample with higher luminescent intensity at 380 nm, the result revealed that the most probable emission after the photon absorption is that around 550 nm.

https://doi.org/10.13053/cys-23-1-3135 98 downloads

12.

Distribución potencial de Musca domestica en el municipio de Jesús María, Aguascalientes, con el uso de escenarios de cambio climático
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Meraz Jiménez, Antonio de Jesús

; López Santos, Armando

; García Munguía, Carlos Alberto

; Torres González, Jorge Alejandro

; García Munguía, Alberto Margarito

Revista mexicana de ciencias pecuarias

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mar 2019, Volume 10 N. 1 Pages 14 - 29

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The housefly M. domestica is a primary domestic pest responsible for food decomposition, and is a vector for more than 100 pathogens in humans and animals. Climate conditions including temperature and relative humidity influence M. domestica development and prevalence. As climate change advances control programs for this species will need to adapt to evolving conditions. A development assay was done of M. domestica at different temperatures and relative humidities to estimate its current potential incidence in Jesús María Municipality, Aguascalientes, Mexico. Local climate is temperate semi-dry (BS1k) with 16 to 18 °C annual average temperature and 500 to 600 mm annual average rainfall. In a completely randomized design, six treatments involving different temperatures and relative humidities during the entire fly lifecycle were analyzed. Development conditions were ideal between 20 and 30 °C, conditions present in the study area between June and August. The CNRMCM5 (RCP 4.5) climate change model was used to predict extreme minimum temperatures in three time horizons: Short (2015-2039); Medium (2040-2060); and Long (2075-2090). Under the Medium and Long scenarios ideal development conditions could last as long as five months, representing a potential increase in the time M. domestica is present in the region, and in the duration of the public and animal health challenges it generates. The present results are important for planning future prevention, monitoring and control programs and strategies.

Resumen: M. domestica es el mayor parásito doméstico que causa descomposición de alimentos y actúa como vector de más de 100 patógenos para la medicina humana y veterinaria, tiene una cercana asociación con el hombre y su ambiente. El objetivo del presente estudio fue evaluar el desarrollo de M. domestica a diferentes niveles de temperatura y humedad relativa y determinar su potencial incidencia en el municipio de Jesús María, Aguascalientes. El estudio se desarrolló en el Centro de Ciencias Agropecuarias de la Universidad Autónoma de Aguascalientes (CCA-UAA), que presenta un clima semiseco templado (BS1k) con promedios anuales de temperaturas y precipitación de 16 a 18 °C y 500 a 600 mm, respectivamente; se evaluaron seis tratamientos con diferentes temperaturas y humedad relativa. Los resultados se analizaron en un diseño completamente al azar y mediante comparación de medias de Tukey (α=0.005). Los resultados muestran que la mosca doméstica se puede desarrollar a temperaturas ambientales de 20 a 30 °C; y con base en el modelo CNRMCM5 (RCP4.5) en diferentes horizontes de tiempo cercano (2015-2039), medio (2040-2060) y lejano (2090) de escenarios de cambio climático, la mosca tendrá una duración de alrededor de tres meses para el horizonte cercano y de cinco meses para el medio y lejano. Con estos datos se provee información importante que permite planear el desarrollo de estrategias para su prevención, monitoreo y control.

https://doi.org/10.22319/rmcp.v10i1.4241 1607 downloads

13.

Descripción anatómica, clínica y sobrevida de los pacientes con atresia pulmonar que han sido llevados a angioplastia con stent en el ductus arterioso persistente en el periodo 2009-2014
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García-Torres, Alberto E.

; Caicedo-Roa, Mónica

; Ronderos-Dumit, Miguel A.

; Reyes-Casas, Martha C.

; Cárdenas, Ivonne

; Stapper-Ortega, Claudia M.

; Guerra-Romero, Alberto R.

Revista Colombiana de Cardiología

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feb 2019, Volume 26 N. 1 Pages 43 - 50

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Objetivo: describir las características anatómicas, la evolución clínica y la sobrevida de los pacientes con atresia pulmonar que han sido llevados a angioplastia con stent en ductus arterioso persistente y determinar si existen diferencias significativas en la saturación al inicio y final del procedimiento y a las 6, 12 y 24 horas posprocedimiento. Materiales y métodos: estudio analítico, descriptivo tipo cohorte. La población de estudio se tomó de las bases de datos del servicio de Cardiología pediátrica de una institución especializada en la ciudad de Bogotá, Colombia. Se incluyeron pacientes con diagnóstico de atresia pulmonar sometidos a angioplastia, en tanto que se excluyeron aquellos con cirugía cardiovascular previa. El análisis estadístico se realizó en STATA® 12,0, mediante estadística descriptiva, curvas de Kaplan-Meier y ANOVA de medidas repetidas. Resultados: se identificaron 237 pacientes con atresia pulmonar. Se seleccionaron 30 de los cuales se excluyeron 5. En total se construyó una cohorte de 25 pacientes que fueron llevados a angioplastia, 52% con atresia pulmonar con comunicación interventricular. Edad promedio 12,2 días, peso 2.698 g, diámetro del DAP 3,8 mm (DE = 1,1), índice de McGoon media 1,35. El implante del stent fue exitoso en todos los pacientes; sin embargo 2 fallecieron en la sala de procedimientos y uno durante las 6 horas siguientes. Las complicaciones más frecuentes fueron paro cardiorrespiratorio (n = 2), trombosis del stent (n = 2) y bacteriemia (n = 2). La mortalidad a 30 días fue del 28% (n = 7); durante el tiempo total fue del 36% (n = 9). Por medio del ANOVA no se encontraron diferencias significativas en los promedios de saturación en los cinco tiempos de interés. Conclusiones: la atresia pulmonar es una patología compleja que requiere intervención invasiva para el mantenimiento de la capacidad circulatoria de los pacientes. Este estudio muestra que a pesar de una intervención efectiva, la mortalidad a los 30 días es elevada. No se encontraron diferencias en los tiempos de saturación, lo que sugiere que mantiene la saturación de los pacientes de una forma no distinta que con la prostaglandina E (PGE1) pero garantiza la permeabilidad del ductus.

Abstract Objective: the aim of this study is to describe the anatomical characteristics, the clinical progression, and survival of patients with pulmonary atresia subjected to angioplasty with a stent in patent ductus arteriosus (PDA), and to determine if there are significant difference in the saturation at the beginning and the end of the procedure, and at 6, 12, and 24 hours after the procedure. Materials and methods: An analytical and descriptive cohort study was conducted on a population taken from the database of a Paediatric Cardiology Department of a specialised institution in the city of Bogota, Colombia. Patients with pulmonary atresia subjected to angioplasty were included, and those with previous cardiovascular were excluded. The statistical analysis was performed using STATA® 12.0, by means of descriptive statistics, Kaplan-Meier curves and repeated measurements ANOVA. Results: A total of 237 patients with pulmonary atresia were identified. Of the 30 that were selected, 5 were excluded, leaving a total of 25 patients that were subjected to angioplasty. Interventricular communication was observed in 52%. The mean age was 12.2 days, with a mean weight of 2.698 g, a mean PDA diameter of 3.8 mm (SD = 1.1), and a mean McGoon index of 1.35. Although the stent implant was successful in all patients, two died in the procedures room, and another one during the following 6 hours. The most common complications were, cardiorespiratory arrest in 2 patients, thrombosis of the stent in 2, and bacteraemia in two patients. The mortality at 30 days was 28% (7), and 36% (9) during the total time. Using ANOVA, no significant differences were found in the saturation means at the five times of interest. Conclusions: Pulmonary atresia is a complicated condition that requires invasive intervention in order to maintain the circulatory capacity of the patients. This study shows that, despite an effective intervention, the 30-day mortality is elevated. No differences were, found in the saturation times, which suggest that saturation is maintained in the patients in a way not unlike that with prostaglandin E (PGE1), but ensures the patency of the ductus.

https://doi.org/10.1016/j.rccar.2018.05.013 561 downloads

14.

First Colombian consensus on congenital Chagas and clinical approach for women of child-bearing age diagnosed with Chagas
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Cucunubá, Zulma M.

; Valencia-Hernández, Carlos A.

; Puerta, Concepción J.

; Sosa-Estani, Sergio

; Torrico, Faustino

; Cortés, Jorge Alberto

; Ramirez, Juan David

; Vera, Mauricio J.

; Acosta, Belkis Xiomara

; Álvarez, Carlos Arturo

; Muller, Edith Ángel

; Beltrán, Mauricio

; Bermúdez, María Isabel

; Berrío, Maritza

; Camacho Moreno, Germán

; Castellanos, Yeny Zulay

; Criollo, Ingrid

; Flórez, Astrid Carolina

; Guerra Morales, Patricia

; Herazo, Rafael Antonio

; Hernández, Diana Carolina

; León, Cielo Maritza

; Medina Camargo, Manuel

; MedinaAlfonso, Mabel

; Pachón, Edwin

; Paez Fonseca, Bernardo

; Parra, María Luisa

; Pavia, Paula X.

; Quiróz, Franklin Roberto

; Ríos, Lyda Constanza

; Roa, Nubia Lucía

; Torres, Fernando

; Uribe Rivero, Luz Marina

Infectio

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dec 2017, Volume 21 N. 4 Pages 255 - 266

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La transmisión congénita de la enfermedad de Chagas ha sido poco estudiada en Colombia y existen pocos procedimientos rutinarios en el sistema de salud para el manejo de esta enfermedad. Por ello se desarrolló un consenso de expertos dirigido a generar recomendaciones de diagnóstico y tratamiento de Chagas con- génito y orientación a mujeres en edad fértil. Con ese propósito se realizó una búsqueda extensiva de la literatura, empleando una combinación de términos Mes (Chagas, Chagas congénito, prevención, control, diagnóstico, tratamiento y embarazo) para reflejar el estado del arte en cada tema de interés. Después de ello, se leyeron los resúmenes y aquellos seleccionados para análisis del texto completo. La literatura relevante se sintetizo, clasifico y organizo en tablas y se presentó al panel de expertos, el cual estaba constituido por 30 profesionales en diferentes áreas. Mediante la metodología Delphi se realizaron 2 rondas de cuestionarios virtuales y una reunión presencial en los cuales se evaluaron los niveles de acuerdo entre los participantes. Los puntos con falta de consenso durante las 2 rondas virtuales se expusieron durante las mesas de discusión en la ronda presencial. La evidencia utilizada se adaptó a las particularidades nacionales según el caso y se aprobó el contenido del documento final. Se propone que estas recomendaciones sean usadas por profesionales de la salud en Colombia.

Abstract Congenital transmission of Chagas disease has not been extensively studied in Colombia, and there are no standardized processes in the health system regarding the specific diagnosis, treatment and follow-up of this disease. To generate recommendations on congenital Chagas disease and Chagas in women of childbearing age in Colombia, a consensus of experts was developed. An extensive literature search through the Medline database was carried out using the MeSH terms: «Chagas disease/congenital», «prevention and control», «diagnosis», «therapeutics» and «pregnancy». Appropriate abstracts were selected and the full texts were analyzed. The relevant information was synthesized, classified, and organized into tables and figures and was presented to a panel of experts, which was composed of 30 professionals from various fields. Based on the Delphi methodology, three rounds of consultation were conducted. The first and second rounds were based on electronic questionnaires that measured the level of consensus of each question among the participants. The third round was based on a face-to-face discussion focusing on those questions without consensus in the previous consultations. The evidence was adapted to national circumstances on a case-by-case basis, and the content the final document was approved. These recommendations are proposed for use in routine medical practice by health professionals in Colombia.

https://doi.org/10.22354/in.v21i4.689 799 downloads

15.

Diagnóstico, tratamiento y seguimiento de un tumor de reciente descripción: el carcinoma análogo secretor de mama (MASC) de glándula salival. A propósito de 2 nuevos casos
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Gavín-Clavero, Marina Alexandra

; Simón-Sanz, M. Victoria

; López-López, Ana M.

; Valero-Torres, Alberto

; Saura-Fillat, Esther

Revista Española de Cirugía Oral y Maxilofacial

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dec 2017, Volume 39 N. 4 Pages 221 - 228

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Introduction: Mammary analogue secretory carcinoma (MASC) is a new salivary gland tumour with few cases reported. Pre-operative diagnosis is difficult, and treatment and follow-up are still under study. Material and method: A systematic review was conducted on 367 parotid tumours treated between January 2011 and December 2015 at the University Hospital Miguel Servet, Spain. Of the 367 cases operated on, 45 were malignant, and of these, only two cases were MASC. Results: Of the 367 parotid tumours reviewed, 45 were malignant, and two of them MASC. Sub-total and superficial parotidectomy combined with radiation therapy has been the treatment of choice. They showed no recurrence after 12 and 18 months. Discussion: A review is presented on the studies published in the literature on the differential diagnosis with other salivary gland tumours, taking into account their cytological and immunohistochemical results, focussing on the most specific markers for the diagnosis of MASC. Conclusion: Pre-operative diagnosis of MASC is rarely successful. Its treatment and long-term survival is largely unknown, thus there is a need for more prospective studies, as well as new cases that should be documented and followed-up.

Resumen Introducción: El carcinoma análogo secretor de mama (MASC) es un tumor de glándula salival de reciente aparición con pocos casos descritos. Tiene un diagnóstico preoperatorio difícil y su tratamiento y seguimiento todavía siguen en estudio. Material y métodos: Revisión sistemática de 367 tumores parotídeos intervenidos entre enero de 2011 y diciembre de 2015 en el Hospital Universitario Miguel Servet. De los 367 casos operados, 45 eran malignos, y de estos, encontramos 2 únicos casos de MASC. Resultados: Cuarenta y cinco de los 367 tumores parotídeos eran malignos, siendo 2 de ellos MASC. La parotidectomía subtotal y superficial asociada a la radioterapia ha sido el tratamiento de elección. Tras 12 y 18 meses, no se han evidenciado recidivas. Discusión: Revisión de los estudios publicados en la literatura sobre su diagnóstico diferencial con otros tumores de glándula salival y su tratamiento, teniendo en cuenta los resultados citológicos e inmunohistoquímicos de cada uno de ellos, y destacando cuáles son los marcadores más específicos para el diagnóstico de MASC. Conclusión: El diagnóstico preoperatorio de este tumor casi nunca es acertado, y todavía no se conoce su tratamiento y supervivencia a largo plazo, por lo que más estudios prospectivos y nuevos casos deben ser documentados y seguidos.

https://doi.org/10.1016/j.maxilo.2016.11.001 934 downloads

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