Abstract Objective the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats. Methodology ovariectomy was performed on 30 Wistar rats, aged six months (Rattus novergicus), and, after 90 days, osseointegrated implants were installed in each tibial metaphysis. The study groups were divided into the animals that received intraperitoneal ozone at a concentration of 700 mcg/kg — OZ Group (n=15) — and a control group that received an intraperitoneal saline solution and, for this reason, was named the SAL group (n=15). The applications for both groups occurred during the immediate post-operative period on the 2nd, 4th, 6th, 8th, 10th, and 12th day post-surgery. At various stages (14, 42, and 60 days), the animals were euthanized, and tests were performed on their tibiae. These tests include histomorphometric and immunohistochemical analyses, computerized microtomography, sampling in light-cured resin for calcified sections, and confocal microscopy. The obtained data were then analyzed using One-way ANOVA and the Shapiro-Wilk, Kruskal-Wallis, and student t-tests (P<0.05). Results our findings indicate that the OZ group (3.26±0.20 mm) showed better cellular organization and bone neoformation at 14 days (SAL group, 0.90±1.42 mm) (P=0.001). Immunohistochemistry revealed that osteocalcin labeling was moderate in the OZ group and mild in the SAL group at 14 and 42 days post-surgery. The data from the analysis of calcified tissues (microtomography, histometric, and bone dynamism analysis) at 60 days showed no statistically significant differences between the groups (P=0.32). Conclusion it was concluded that ozone therapy anticipated the initial phases of the peri-implant bone repair process.

ABSTRACT This study aimed to assess the growth performance of bullfrog (Aquarana catesbeiana) tadpoles subjected to different management practices and diets. Two distinct feeding management strategies were evaluated: broadcast feeding and the use of a trough. Regarding the diet, two formulations were tested: the first involved feed with 28% crude protein (CP) for the initial 30 days, followed by feed with 36% CP for the subsequent 30 days; the second treatment consisted of a commercial feed designed for tropical carnivorous fish, containing 40% CP, administered throughout the experimental period (60 days). The experiment was conducted in sixteen 30-L containers, each undergoing a daily water renewal of 200% of its volume, and tadpoles were stocked at a density of one tadpole/L (0.081±0.075 g initial weight). Growth performance was evaluated. The experimental design was factorial (2 × 2) with four replicates. Data were analyzed using analysis of variance and Tukey’s test (α = 0.05). Tadpoles fed the commercial feed outperformed (final weight of 3.329 g (FW), feed conversion (FC) of 1.423 g/g, and protein efficiency rate (PER) of 1.578 g/g) those fed the experimental diets in all growth performance parameters except for PER, whose best results were achieved with the experimental diets (FW of 2.708 g; FC of 1.579 g/g, and PER of 1.880 g/g). Regarding management practices, the use of a trough yielded (FC of 1.409 g/g) superior outcomes compared with the traditional method (FC of 1.579 g/g); therefore, the combination of a trough and the commercial feed regimen demonstrated the best results.

Abstract We investigate the occurrence of enterobacteria and antimicrobial resistance in passerines of the genus Sporophila seized from illegal trafficking. A total of 35 birds, apparently healthy and from illegal breeding, were sent to the Laboratory of Ornithological Studies at the State University of Ceará (Fortaleza, Ceará, Brazil) by environmental agencies. Cloacal swabs were collected from each bird and subjected to traditional microbiological processing, using standard cultivation and bacterialidentification techniques. We conducted antimicrobial susceptibility testing using the disc-diffusion method. Twenty-three birds (65.7%) exhibited enterobacteria, with Escherichia coli (28.6%) and Serratia liquefaciens (25.7%) being the most common. Antimicrobial resistance in total isolates was observed most frequently in relation to ciprofloxacin (28.1%), followed by tetracycline (25.0%) and enrofloxacin (18.8%). The rate of resistance to Serratia liquefaciens was the highest (i.e., 66.6% of isolates). The birds’ cloacal samples revealed several members of the Enterobacterales order, with E. coli and S. liquefaciens being the most prevalent. We also observed antimicrobial resistance to several drugs, as well as cases of multi-resistance. Antimicrobial resistance is clearly present in wild birds resulting from illegal keeping. These findings highlight the importance of considering antimicrobial-resistant bacteria in release programs to prevent these microorganisms from dispersing into the environment.

Resumo O objetivo desta pesquisa foi investigar a ocorrência de enterobactérias em passeriformes do gênero Sporophila, provenientes do tráfico ilegal de animais, e analisar sua resistência antimicrobiana. Um total de 35 aves, aparentemente saudáveis e provenientes de criações ilegais, foram encaminhadas ao Laboratório de Estudos Ornitológicos da Universidade Estadual do Ceará (Fortaleza, Ceará, Brasil) por órgãos ambientais. Amostras obtidas a partir de suabes cloacais foram coletadas de cada ave e submetidas a processamento microbiológico tradicional, utilizando técnicas padrão de cultivo e identificação bacteriana. O teste de sensibilidade aos antimicrobianos foi avaliado pelo método de disco de difusão. Das amostras examinadas, 23 (65,7%) apresentaram a presença de enterobactérias, sendo Escherichia coli (28,6%) e Serratia liquefaciens (25,7%) as mais frequentes. A resistência antimicrobiana referente aos isolados totais foi observada com mais frequência em relação à ciprofloxacina (28,1%), seguida por tetraciclina (25,0%) e enrofloxacina (18,8%). Especificamente em relação à Serratia liquefaciens, a taxa de resistência foi a mais altas, atingindo 66,6% dos isolados. Com base nos resultados obtidos, podemos concluir que as amostras cloacais das aves apresentaram isolamento de diversos membros da ordem Enterobacteriales, sendo E. coli e S. liquefaciens as mais frequentes. Também foi observada a ocorrência de resistência antimicrobiana a diversos fármacos utilizados, assim como casos de multiresistência, o que mostra que esse problema está presente em pássaros silvestres oriundo de manutenções ilegais. Isso ressalta a necessidade de considerar a presença de bactérias resistentes a antimicrobianos em programas de soltura, visando evitar a dispersão desses microrganismos no meio ambiente.

ABSTRACT This research aimed to develop a management model to increase the capacity of integrating processes in the human resources area in a large Brazilian service organization. The research used a qualitative and quantitative approach to analyze data from the organization’s value chain and to evaluate the consistency of integrations and artifacts mapped in light of stakeholder requirements under the theory of constraints. Among the main results, two scales were developed to measure organizational consistency: a) validation of the level of updating of artifacts; and, b) diagnosis of technological adherence. With the model, all 16 organizational subsystems of the context, 142 artifacts and 666 integrations were mapped. The applied model resulted in significant global gains in the processes’ integration of the researched value chain.

RESUMO A pesquisa teve como objetivo desenvolver um modelo de gestão da capacidade de integração de processos na área de Recursos Humanos em uma grande organização brasileira que integra uma rede global de prestação de serviços. Utilizou-se de abordagem qualitativa e quantitativa para analisar os dados da cadeia de valor da organização e para avaliar a consistência das integrações e artefatos mapeados diante dos requisitos dos stakeholders, sob a abordagem da Teoria das Restrições. Entre os principais resultados, foram desenvolvidas duas escalas de aferição de consistência organizacional: a) de validação do nível de atualização dos artefatos; e b) diagnóstico da aderência tecnológica. Com o modelo, foram mapeados todos os 16 subsistemas organizacionais do contexto, 142 artefatos e 666 integrações. O modelo aplicado resultou em ganhos globais significativos na integração de processos na cadeia de valor pesquisada.

RESUMEN Esta investigación tuvo como objetivo desarrollar un modelo de gestión de la capacidad de integración de procesos en el área de recursos humanos en una gran organización brasileña que forma parte de una red global de prestación de servicios. La investigación utilizó un enfoque cualitativo y cuantitativo para analizar datos de la cadena de valor de la organización y evaluar la consistencia de las integraciones y artefactos mapeados a la luz de los requisitos de los stakeholders, bajo el enfoque de la teoría de las restricciones. Entre los principales resultados, se desarrollaron dos escalas para medir la consistencia organizacional: a) validación del nivel de actualización de los artefactos; y, b) diagnóstico de adherencia tecnológica. Con el modelo se mapearon los 16 subsistemas organizativos del contexto, 142 artefactos y 666 integraciones. El modelo aplicado resultó en importantes ganancias globales en la integración de procesos en la cadena de valor investigada.

Resumo A vacina influenza é recomendada para todos trabalhadores de saúde, mas sua cobertura permanece insatisfatória. Estudo transversal que objetivou identificar fatores associados à vacinação contra influenza, realizado com trabalhadores de saúde de um grande Complexo Hospitalar de Salvador, Bahia. Utilizou-se questionário autoaplicável baseado nos modelos “Conhecimento, Atitudes e Práticas” e “Health Belief Model”. A variável dependente foi a vacinação contra influenza em 2014, e as independentes representaram fatores sociodemográficos, histórico vacinal, conhecimentos e atitudes sobre influenza/vacina influenza. Usou-se regressão logística, calculou-se odds ratio a intervalos de confiança de 95%, ajustando para sexo, idade e profissão. Elegeu-se o melhor modelo multivariado através de eliminação retrógada e do Critério de Informação de Akaike. Participaram 755 trabalhadores. A cobertura da vacina influenza foi de 61,5%, sendo maior entre enfermeiros (69,0%) e menor entre médicos (49,1%). Os fatores associados a vacinar-se contra influenza foram: conhecer que mesmo estando saudável deve-se vacinar (OR = 3,15; IC95%:1,74-5,71); saber que a vacina não protege por muitos anos (OR = 2,08; IC95%:1,30-3,33); e não temer efeitos adversos pós-vacinais (OR = 1,93; IC95%:1,26-2,95).

Abstract Influenza vaccine is recommended for all health workers, but vaccination coverage remains unsatisfactory. A cross-sectional study that aimed to identify factors associated with influenza vaccination was carried out with health workers from a large Hospital Complex in Salvador, Bahia. A self-administered questionnaire was used based on the models “Knowledge, Attitudes and Practices” and “Health Belief Model”. The dependent variable was the vaccination status against influenza in 2014, and the independent variables were sociodemographic factors, vaccine history, knowledge and attitudes about influenza/influenza vaccine. Logistic regression was used, odds ratio was calculated with 95% confidence intervals, adjusting for sex, age and occupation. The best multivariate model was chosen through backwards elimination and the Akaike Information Criterion. 755 workers participated. Influenza vaccine coverage was 61.5%, being higher among nurses (69.0%) and lower among physicians (49.1%). The factors associated with being vaccinated against influenza were: knowing that even when healthy, one must vaccinate against influenza (OR = 3.15; 95%CI:1.74-5.71); knowing that the vaccine does not protect for many years (OR = 2.08; 95%CI:1.30-3.33); and not to be afraid of post-vaccine adverse effects (OR = 1.93; 95%CI: 1.26-2.95).

The SEW - Strategic Empowering Weighed Diagnosis Method as a Tourism Destinations Analysis Tool and its Application in Ilhéus/BA - Brazil. The tourism´s studies are incipient compared with other fields. The scientific production is in a development stage due the complexity and specificity of this activity. Therefore, a new diagnosis methodology of tourist destinations was developed and applied as a pilot study in the city of Ilhéus, Bahia, Brazil. This new method, called Strategic Empowering Weighed Diagnosis - SEW is the fusion of two traditional methods of diagnosis, SWOT (Weaknesses, Threats, Strengths and Opportunities) and the Delphi technique. The collection and systematization of data was structured in three stages: a SWOT analysis, followed by the Delphi method and statistical treatments. The analysis was guided by descriptive and explanatory methods. The fusion of the two techniques proved to be feasible and interesting, however there was a deficiency to access the specialists in Delphi analysis. We hope that the study can support the achievement more effective planning, and thereby assist the actions and decisions of managers and civil society organized action plans and regional development projects.

El estudio del turismo en comparación con otras áreas del conocimiento aún es muy incipiente. La producción científica a pesar de que ha crecido aún carece de madurez y de análisis compatibles con la especificidad y complejidad de la actividad. Para este estudio se desarrolló una nueva metodología de diagnóstico de destinos turísticos que fue aplicada como estudio piloto en la ciudad de Ilhéus/BA, Brasil. Este nuevo método, denominado Diagnóstico Estratégico Participativo Ponderado - DEP, consiste en la fusión de dos métodos tradicionales de diagnóstico: el DAFO (Deficiencias, Amenazas, Fuerzas y Oportunidades) y la técnica Delphi. El estudio tiene carácter interdisciplinario con un abordaje cuantitativo. La recolección y sistematización de los datos fue estructurada en tres etapas: el Análisis DAFO, el Método DELPHI y el tratamiento estadístico. El análisis de los resultados se realizó con el método descriptivo. La fusión de las dos técnicas resultó viable e interesante pero surgió una dificultad de acceso a los especialistas en el análisis Delphi. Se espera que el estudio sirva de base para la realización de planificaciones más eficaces y ayude en la toma de decisiones a los gestores y la sociedad civil organizada.

OBJETIVOS: Descrever as principais características de pacientes com câncer de mama admitidas em dois serviços de referência para o tratamento desse tipo de câncer no norte de Minas Gerais, incluindo estágio da doença ao diagnóstico e local de tratamento. MÉTODOS: Realizou-se estudo transversal e descritivo, avaliando 288 prontuários de pacientes do gênero feminino com câncer de mama, admitidas entre janeiro de 2006 a dezembro de 2009, oriundas de um serviço público e de um privado. As variáveis analisadas foram submetidas a tratamento estatístico por meio dos testes qui-quadrado e regressão logística multinomial. RESULTADOS: Observou-se que 68,1% da população analisada procediam do serviço público. Predominaram pacientes com mais de 50 anos (54,5%), casadas (59%) e com filhos (87,8%). Dentre a população estudada, a média de idade foi de 63 anos, sendo que em 42,7% dos casos prevaleceu o intervalo de tempo acima de 6 meses entre a suspeita clínica e a confirmação diagnóstica. Em 47,6% das mulheres o diagnóstico foi tardio (estágios III e IV). 20,1% tinham histórico familiar de câncer de mama; 20,8% faziam autoexame das mamas e 41% faziam mamografia. CONCLUSÃO: Verificou-se maior prevalência de pacientes nos estágios III e IV no serviço público quando comparado ao privado. O tempo prolongado entre a suspeita clínica e a confirmação diagnóstica, a ausência de história familiar de câncer de mama e a não realização de mamografia de rastreamento são observados, neste estudo, como os principais fatores associados ao diagnóstico tardio.

OBJECTIVE: To describe the main characteristics, including stage of disease and local treatment of patients admitted to two reference services for the treatment of breast cancer in the North of Minas Gerais. METHODS: We conducted a cross-sectional descriptive study. We evaluated medical records of 288 female patients with breast cancer admitted between January 2006 and December 2009, referred from a public hospital and a private clinic. Variables were analyzed using the chi-square test and multinomial logistic regression. RESULTS: 68.1% of patients were referred from the public hospital. There was a predominance of patients over 50 years old (54.5%), married (59%) and with children (87.8%). The mean age of the population studied was 63 years old. Time between suspected cancer and confirmation of diagnosis was over six months in 42.7% of patients. Cancer diagnosis was late (stage III and IV) in 47.6% of patients. Family history of breast cancer was present in 20.1%, 20.8% of them had performed self-breast examination, and 41% had been submitted to a mammogram. CONCLUSION: There was a higher prevalence of stage III/IV patients from the public service when compared to the private sector. We found that the major factors associated with the late diagnosis of breast cancer were the delay between suspected and confirmed diagnosis, the absence of family history of breast cancer and not having a mammogram.

Neuroblastoma is the most common extracranial solid malignancy in children but rarely described in adults, being 10% of all cases diagnosed after the first decade of life. We report a 23 year-old black woman with a mass at paravertebral region of T3-T5, multiple lesions in vertebral bodies and expanding skull-brain lesion at the right parietal region. Immunohistochemical analysis (negative for CD99, CD20, CD3 and desmin; and positive chromogranin, synaptophysin and NB84) confi rmed the diagnosis of neuroblastoma. The patient was submitted to 12 cycles of chemotherapy receiving VAC (vincristine/doxorubicin/cyclophosphamide) interspersed with ICE (ifosfamide/mesna/etoposide) and doxorubicin was replaced by actinomycin in the 7th cycle. She had good tolerance to this therapy, and has been clinically stable.

El neuroblastoma es el tumor maligno sólido extracraneal más común en niños. Sólo el 10% de los casos se diagnostican después de la primera década de vida. Presentamos una paciente afroamericana de 23 años, con una masa paravertebral en T3-T5, múltiples lesiones en los cuerpos vertebrales y una lesión expansiva en la región parietal derecha. El estudio inmmunohistoquímico (negativo para CD99, CD20, CD3 y desmina y positivo para cromogranina, sinaptofisina y NB84), confirmó el diagnóstico de neuroblastoma. La paciente fue sometida a 12 ciclos de quimioterapia recibiendo VAC (vincristina / doxorubicina/ cyclofosfamida) intercalada con ICE (ifosfamida/ mesna/ etoposido). La doxorubicina fue reemplazada por actinomicina en el séptimo ciclo. La paciente toleró bien la quimioterapia y está clínicamente estable.

Toxoplasmose é uma zoonose que vem sendo objeto de estudos no Brasil e em todas as partes do mundo. Os cães são considerados sentinelas da infecção, podendo carrear o agente pelo ambiente. Levantamentos soro-epidemiológicos desses animais são importantes ferramentas de vigilância e controle da doença em programas de saúde. Neste estudo a performance do Teste de Aglutinação Modificada (MAT) no sorodiagnóstico da toxoplasmose canina foi avaliado e comparado à reação de imunoflorescência indireta (RIFI). Uma amostra de 157 soros de cães do município de Monte Negro, Rondônia, com 76.40% de animais positivos ao Toxoplasma gondii (RIFI =16) foi analisado utilizando o MAT (=25) e apresentou sensibilidade de 85,00% (Intervalo de Confiança 95,00%: 79,4-90,60%) e especificidade de 100,00%.

Toxoplasmosis is a zoonosis that has been the subject of study in Brazil and worldwide. The dogs are sentinels for the infection and can carry Toxoplasma gondii in the environment. Seroepidemiological surveys of these animals are an important tool in the surveillance and control of the disease and inform decision-making in health programs. In this study the performance of the Modified Agglutination Test (MAT) in the serodiagnosis of canine toxoplasmosis is evaluated and compared to the indirect immunofluorescent-antibody test (IFAT). A sample of 157 dog sera from the county of Monte Negro, Rondônia, with 76.40% positive reactions for Toxoplasma gondii (IFAT =16) was analyzed using the MAT (=25), presenting sensitivity of 85.00% (Confidence Interval 95.00%: 79.4 - 90.60%) and specificity of 100.00%.