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Extracts from Tissue Cultures of Crotalaria spp. as Potential Natural Alternative for Controling Root-Knot Nematodes
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Honório, Amanda P.

; Blank, Daiane E.

; Demuner, Antonio J.

; Souza, Gustavo S. F.

; Buonicontro, Dalila S.

; Varejão, Eduardo V. V. Zocolo, Guilherme J. Guedes, Jhonyson A. C. Firmino, Maria J. M. Carvalho, Jilma L. B. R. D. Santos, Marcelo H. Faria, Daniele V. Vieira, Lorena M. Otoni, Wagner C. Machado, Franklin J.

Journal of the Brazilian Chemical Society

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2025, Volume 36 N. 5 elocation e-20240227

Abstract: En | Text: En | PDF: En

Plants of the genus Crotalaria are known for their antagonistic effect against nematodes. It has been found that pyrrolizidine alkaloids are the main metabolites involved in such antagonistic activity. Aiming at obtaining extracts with higher alkaloid content and enhanced potential for use as bionematicides, we investigated the chemical composition and nematicidal activity of extracts obtained from Crotalaria juncea and Crotalaria ochroleuca cultivated in vitro through micropropagation. Remarkably, extracts from the callus of C. ochroleuca (lethal concentration of 95% (LC95) = 157.7 μg mL-1) and C. juncea (LC95 = 189.9 μg mL-1) exhibited high toxicity against Meloidogyne javanica. The ultra performance liquid chromatography coupled to quadrupole time-of-flight with high mass spectrometry (UPLC-QTOF-MSE) analysis revealed the presence of pyrrolizidine alkaloids, flavones, flavone glycosides, and isoflavones. These findings highlight the potential of tissue culture to obtain extracts from Crotalaria species compared to conventionally cultivated plants and provide a higher concentration of metabolites with nematicidal effects, paving the way for sustainable agriculture.

https://doi.org/10.21577/0103-5053.20240227

Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies
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Ferreira, Juliana Carvalho

; Vianna, Arthur Oswaldo de Abreu

; Pinheiro, Bruno Valle

; Maia, Israel Silva

; Baldisserotto, Sérgio Vasconcellos

; Isola, Alexandre Marini

; Cavalcanti, Alexandre Biasi Gama, Ana Maria Casati Nogueira da Rocha, Angelo Roncalli Miranda Oliveira, Antonio Gonçalves de Serpa Neto, Ary Farias, Augusto Manoel de Carvalho Orlando, Bianca Rodrigues Esteves, Bruno da Costa Mazza, Bruno Franco Silveira, Camila de Freitas Martins Soares Carvalho, Carlos Roberto Ribeiro de Toufen Junior, Carlos Barbas, Carmen Silvia Valente Teixeira, Cassiano Silveira, Débora Dutra da Medeiros, Denise Machado Parolo, Edino Costa, Eduardo Leite Vieira Caser, Eliana Bernadete Oliveira, Ellen Pierre de Banholzer, Eric Grieger Carvalho, Erich Vidal Amorim, Fabio Ferreira Saddy, Felipe Gonçalves, Fernanda Alves Ferreira Galas, Filomena Regina Barbosa Gomes Zanatta, Giovanna Carolina Gardini Silva, Gisele Sampaio Westphal, Glauco Adrieno Matos, Gustavo Faissol Janot de Souza, João Claudio Emmerich de Silva Junior, João Manoel Valiatti, Jorge Luis dos Santos Nascimento Junior, José Ribamar do Rocco, Jose Rodolfo Hajjar, Ludhmila Abrahão Forgiarini Junior, Luiz Alberto Malbuisson, Luiz Marcelo Sá Holanda, Marcelo Alcantara Amato, Marcelo Britto Passos Park, Marcelo Oliveira, Marco Antonio da Rosa e Reis, Marco Antonio Soares Tavares, Marcos Soares Souza, Mario Henrique Dutra de Damasceno, Marta Cristina Pauleti Lira-Batista, Marta Maria da Silva Pattacini, Max Morais Assunção, Murillo Santucci Cesar de Oliveira, Neymar Elias de Franzosi, Oellen Stuani Rocco, Patricia Rieken Macedo Caruso, Pedro Silva, Pedro Leme Mendes, Pedro Vitale Duarte, Pericles Almeida Delfino Santa Neto, Renato Fabio Alberto Della Rodrigues, Ricardo Goulart Cordioli, Ricardo Luiz Palazzo, Roberta Fittipaldi Goldwasser, Rosane Pinheiro, Sabrina dos Santos Justino, Sandra Regina Nemer, Sergio Nogueira Oliveira, Vanessa Martins de Silva, Vinicius Zacarias Maldaner da Nedel, Wagner Luis Bellissimo-Rodrigues, Wanessa Teixeira Oliveira Filho, Wilson de

Critical Care Science

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2025, Volume 37 elocation e20250242en

Abstract: En | Text: En | PDF: En

ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.

https://doi.org/10.62675/2965-2774.20250242-en

Multiresidue Method for Quantification of Nitroimidazoles, Anthelmintics, Amphenicols, and Dyes in Meat, Shrimp, and Fish by Using a Modified QuEChERS-type Extraction and Isotope Dilution Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry Nitroimidazoles Anthelmintics Amphenicols Meat Shrimp QuEChERStype QuEChERS type UltraHigh Ultra High ChromatographyTandem Chromatography Tandem
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Souza, Leonardo F. de

; Pereira, Felipe L. P.

; Silva, Alisson L. D.

; Lana, Mary Ane G. Paiva, Cristiana R. de Gloria, Matheus M. M. F. Fernandes, Wagner L. Nogueira, Raquel

Journal of the Brazilian Chemical Society

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2025, Volume 36 N. 2 elocation e-20240206

Abstract: En | Text: En | PDF: En

This paper presents an analytical multiresidue method for the quantification of 7 nitroimidazoles, 19 anthelmintics, 3 amphenicols, and 4 dyes in poultry, pork, beef, horse, shrimp, and fish samples by isotope dilution ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) in a single 6 min run. Samples were prepared using a modified quick, easy, cheap, effective, rugged and safe (QuEChERS)-type extraction with ethyl acetate and Na2SO4-NaCl (2:1), concentration into dimethyl sulfoxide (DMSO), and defatting by liquid-liquid extraction (LLE) with n-hexane. No clean-up using solid-phase extraction (SPE) cartridges or dispersive solid-phase extraction (DSPE) was necessary. The linearity ranges (in μg kg-1) were 0.10-0.60 for chloramphenicol, 0.50-3.0 for dyes, 1.5-9.0 for nitroimidazoles, and 5.0-30.0 for the other drugs. The limits of quantitation (LOQ) were established at the lowest calibration curve levels. Except for chloramphenicol in the horse matrix, analyte recovery and reproducibility were satisfactory (recovery (fREC): 75.0 to 116.6%; coefficient of variation (CV): 1.2 to 29.9%). For the unapproved substances and the substances with a maximum residue level (MRL), respectively, the decision limits (CCα) were 0.14-4.10 and 5.28-1003.60 μg kg-1, while the detection capabilities (CCβ) were 0.13-3.33 and 5.46-11.56 μg kg-1. nitroimidazoles 1 anthelmintics amphenicols poultry pork beef shrimp ultrahigh ultra high UHPLCMS/MS UHPLCMSMS UHPLC MS/MS MS (UHPLC-MS/MS run quick easy cheap effective QuEChERStype QuEChERS type Na2SO4NaCl NaSONaCl Na2SO4 NaCl Na SO 21, 21 2 , (2:1) DMSO, DMSO (DMSO) liquidliquid LLE (LLE nhexane. nhexane n hexane. hexane n-hexane cleanup clean up solidphase solid phase SPE (SPE DSPE (DSPE necessary kg1 kg kg-1 0.100.60 010060 0.10 0.60 0 10 60 0.10-0.6 0.503.0 05030 0.50 3.0 50 0.50-3. 1.59.0 1590 1.5 9.0 5 9 1.5-9. 5.030.0 50300 5.0 30.0 30 5.0-30. drugs LOQ (LOQ levels matrix fREC (fREC) 750 75 75. 116.6% 1166 116 CV (CV) 12 1. 29.9%. 299 29.9% . 29 29.9%) MRL, MRL (MRL) respectively CCα (CCα 0.144.10 014410 0.14 4.10 14 0.14-4.1 5.281003.60 528100360 5.28 1003.60 28 1003 5.28-1003.6 kg1, 1, CCβ (CCβ 0.133.33 013333 0.13 3.33 13 33 0.13-3.3 5.4611.56 5461156 5.46 11.56 46 11 56 5.46-11.5 kg1. UHPLCMS MSMS NaSO Na2SO (2:1 (DMSO kg- 100 0.100.6 01006 010 0.1 060 0.6 0.10-0. 503 0.503. 0503 050 0.5 3. 0.50-3 59 1.59. 159 15 90 9. 1.5-9 030 5.030. 5030 5. 300 30. 5.0-30 (fREC 116.6 (CV 29.9 (MRL 144 0.144.1 01441 014 410 4.1 0.14-4. 281003 5.281003.6 52810036 528 5.2 100360 1003.6 5.28-1003. 133 0.133.3 01333 013 333 3.3 0.13-3. 4611 5.4611.5 546115 546 5.4 1156 11.5 5.46-11. (2: 0.100. 0100 01 0. 06 0.10-0 0.503 05 0.50- 1.59 1.5- 03 5.030 5.0-3 116. 29. 0.144. 0144 41 4. 0.14-4 28100 5.281003. 5281003 52 10036 1003. 5.28-1003 0.133. 0133 0.13-3 461 5.4611. 54611 54 115 11. 5.46-11 (2 0.100 0.10- 5.03 5.0- 0.144 0.14- 2810 5.281003 528100 5.28-100 0.133 0.13- 5.4611 5461 5.46-1 ( 281 5.28100 52810 5.28-10 5.461 5.46- 5.2810 5281 5.28-1 5.281 5.28-

https://doi.org/10.21577/0103-5053.20240206

Prognosis indicators of equine acute abdomen in south Brazil
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Pradella, Gabriela Döwich

; Andrade, Adriana Oliveira

; Tassinari, Wagner de Souza

; Lübeck, Irina

; Martins, Natálie Rodrigues Dutra, Natália Lima Brasil Duarte, Claudia Acosta

Ciência Rural

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2025, Volume 55 N. 1 elocation e20230516

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Os casos de abdome agudo estão entre as doenças mais prevalentes e desafiadoras na medicina equina. O diagnóstico inclui a realização de anamnese e avaliação clínica detalhada do paciente, permitindo a coleta de diversas informações importantes e, adicionalmente, a utilização de exames complementares ajuda a definir o diagnóstico e prognóstico de cada caso. O objetivo principal deste trabalho foi aplicar a análise de correspondência múltipla (ACM) em dados referentes ao exame clínico e desfecho de cavalos com cólica encaminhados para um hospital no Rio Grande do Sul, Brasil. Foram incluídos 58 cavalos na análise e foi possível identificar diferenças significativas entre os grupos, sobreviventes e não sobreviventes. Relacionado aos sinais clínicos, os casos de óbito distinguem-se por dor intensa, falta de motilidade, alteração da mucosa, tempo de preenchimento capilar maior que 2seg., frequência cardíaca maior que 48bpm e presença de refluxo nasogástrico. Como exames complementares, o hematócrito e o lactato sanguíneo demonstraram diferença significativa entre os grupos. Os parâmetros cardiovasculares, como batimento cardíaco, coloração de mucosas e tempo de preenchimento capilar, foram as variáveis com maior contribuição para diferenciar animais que não sobreviveram dos que receberam alta hospitalar. Assim, a avaliação clínica não deve ser subestimada e os exames complementares devem ser utilizados em conjunto para buscar um melhor prognóstico. A ACM permitiu visualizar os dados e prever o desfecho dos pacientes. RESUMO equina paciente adicionalmente caso (ACM Sul Brasil 5 grupos clínicos distinguemse distinguem se intensa motilidade mucosa 2seg seg 2seg. bpm nasogástrico cardiovasculares cardíaco hospitalar Assim pacientes

ABSTRACT: Acute abdomen cases are among the most prevalent and challenging illnesses in equine medicine. The diagnosis includes anamnesis and detailed clinical evaluation of the patient, allowing the gathering of several important information and, additionally, the use of complementary exams helps to define the diagnosis and prognosis of each case. This research applied the multiple correspondence analysis (MCA) in data referring to clinical examination information and outcome of horses with colic referred to a hospital in Rio Grande do Sul, Brazil. Fifty eight horses were included in the analysis and, it was possible to identify significant differences between the groups, survivors and non-survivors. Related to clinical signs, non-survivor cases are distinguished by severe pain, lack of motility, mucosal alteration, capillary refill time greater than 2sec, heart rate more than 48bpm and presence of nasogastric reflux. As complementary exams, hematocrits and blood lactate demonstrate significative difference among the groups. The cardiovascular parameters, including heart rate, mucosal color and capillary refill time, were the variables with the greatest contribution to discriminate animals that non-survive from those that were discharged. Thus, clinical evaluation should not be underestimated and complementary exams should be used in conjunction to seek a better prognosis. The MCA allowed to visualize the data and predict the outcome of the patients. ABSTRACT medicine patient additionally case (MCA Sul Brazil groups nonsurvivors. nonsurvivors non survivors. non-survivors signs nonsurvivor survivor pain motility alteration 2sec sec bpm reflux parameters nonsurvive survive discharged Thus patients

https://doi.org/10.1590/0103-8478cr20230516

Synthesis, Characterization, and Application of Waste Material Made Magnetic Nanoparticles for the Recovery of Adulterated Markings on Metallic Surfaces Synthesis Characterization
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Souza, Daniel B.

; Silva, Bruno G.

; Sommer, Rubem L. Soares, Iane A. Pereira, Gabriela R. Dornellas, Rafael M. Pacheco, Wagner Felippe

Journal of the Brazilian Chemical Society

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2025, Volume 36 N. 3 elocation e-20240162

Abstract: En | Text: En | PDF: En

Serial numbers are marks present on several day-to-day objects, created by manufacturers for purposes such as quality control, product tracking and to prevent counterfeiting. In the case of firearms, these characters can be obliterated or damaged by natural processes or intentionally by criminals to prevent positive identification of stolen property. One non-destructive method employed by crime laboratories for the restoration of obliterated characters is the magnetic particle method. The present work aims to study the synthesis and application of waste-made magnetic nanoparticles in the recovery of adulterated markings. A set of analytical-grade materials and metallic waste magnetic nanoparticles were synthesized for comparison purposes. Chemical characterization tests by X-ray fluorescence, morphological tests by scanning electron microscopy (SEM), and magnetization tests by vibrating sample magnetometer (VSM) were performed. The efficacy of the synthesized nanoparticles was tested on 1020 steel plates previously engraved and adulterated by sanding. Both homemade magnetic nanoparticles demonstrated superior performance compared to commercial magnetic particles. The application of homemade magnetic particles, especially using waste as the source of production, decreases the cost of the material and is environmentally friendly. The development of this material makes magnetic serial number restoration a better option for widespread use in forensic procedures. daytoday day objects control counterfeiting firearms property nondestructive non destructive wastemade made markings analyticalgrade analytical grade Xray X ray fluorescence SEM, SEM , (SEM) VSM (VSM performed 102 sanding particles production friendly procedures (SEM 10 1

https://doi.org/10.21577/0103-5053.20240162

The Work Environment of Primary Health Care Nurses: An Integrative Review
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Lorran Costa de Andrade, Lucas

; Cavalcanti de Farias Brehmer, Laura

; Machado Amazonas, Bruna Alves

; Ferreira Monteiro, Wagner

; Nunes Sicsú, Amélia

; Souza Ramos, Flávia Regina

Aquichan

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sep 2024, Volume 24 N. 3 elocation e2437

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Introducción: Las actividades laborales incorporan elementos físicos, sociales, emocionales y técnicos. En un escenario de constante transformación, es imperativo conocer la literatura científica actual sobre la estructura y circunstancias laborales del equipo de enfermería en Atención Primaria de Salud (APS). Objetivo: Identificar, en la literatura científica, los aspectos relacionados con el ambiente de trabajo que influyen en la labor del equipo de enfermería en APS. Materiales y método: se trata de una revisión bibliográfica integradora realizada en agosto de 2023 en las bases de datos Lilacs, Cinahl, Web of Science, Medline, Scopus y Embase, siguiendo las recomendaciones de The Prisma 2020 Statement. Los criterios de inclusión fueron artículos electrónicos completos, en portugués, inglés o español, publicados entre 2019 y 2023. La revisión utilizó el instrumento Robis para evaluar el riesgo de sesgo. Resultados: La búsqueda identificó 1417 registros en las bases de datos, de los cuales 20 fueron seleccionados para la muestra final. De estos, el 30 % eran de 2020 (n = 6), en portugués, inglés y español. Brasil presentó el mayor número de publicaciones, con 55 % (n = 11), y los estudios cualitativos representaron 55 % (n = 11) del abordaje metodológico. Del análisis surgieron las siguientes categorías temáticas: "elementos psicológicos y emocionales", "recursos humanos, materiales e infraestructura", "relaciones interpersonales", "insatisfacción", "violencia en el trabajo" y "sobrecarga". Conclusiones: El entorno precario en la APS tiene un impacto negativo en los profesionales de enfermería y en la atención a la población. La mejora de las infraestructuras, la dotación de personal y las condiciones de trabajo son esenciales para garantizar una atención de calidad.

Abstract Introduction: Work activities incorporate physical, social, emotional, and technical elements. In a scenario of constant change, it is imperative to understand the current scientific knowledge on the structure and work conditions of nurses in primary health care (PHC). Objective: To identify, in the scientific literature, the aspects related to the work environment that influence the performance of nurses in PHC. Materials and Methods: This is an integrative literature review conducted in August 2023 in the Lilacs, Cinahl, Web of Science, Medline, Scopus, and Embase databases, following the Prisma 2020 Statement guidelines. The inclusion criteria were complete electronic articles, published in Portuguese, English, or Spanish between 2019 and 2023. This review used the ROBIS instrument to assess the risk of bias. Results: The search found 1,417 records in the databases, of which 20 were selected for the final sample. Of these, 30 % were from 2020 (n = 6), published in Portuguese, English, and Spanish. Brazil had the highest number of publications, with 55 % (n = 11), and qualitative studies represented 55 % (n = 11) of the methodological approaches. The following thematic categories emerged from the analysis: "psychological and emotional elements," "human resources, materials, and infrastructure," "interpersonal relationships," "dissatisfaction," "violence in the workplace," and "overload." Conclusion: The precarious environment in PHC has a negative impact on nurses and the care provided to the population. Improvements in infrastructure, personnel, and work conditions are essential to ensure quality care.

Resumo Introdução: As atividades laborais incorporam elementos físicos, sociais, emocionais e técnicos. Em um cenário de constantes transformações, compreender a atualidade científica sobre a estrutura e sobre as circunstâncias laborais dos enfermeiros na Atenção Primária a Saúde (APS) se revela como imperativo. Objetivo: Identificar, na literatura científica, os aspectos relacionados ao ambiente de trabalho que influenciam a atuação dos enfermeiros inseridos na APS. Materiais e método: Se trata-se de revisão integrativa da literatura realizada em agosto de 2023 nas bases de dados Lilacs, Cinahl, Web of Science, Medline, Scopus e Embase, seguindo as recomendações do The Prisma 2020 Statement. Os critérios de inclusão foram artigos eletrônicos completos, em português, inglês ou espanhol, publicados entre 2019 e 2023. A presente revisão utilizou o instrumento Robis para avaliar o risco de viés. Resultados: A pesquisa identificou 1417 registros nas bases de dados, dos quais 20 foram selecionados para a amostra final. Desses, 30 % foram de 2020 (n = 6), em português, inglês e espanhol. O Brasil teve o maior número de publicações, com 55 % (n = 11), e os estudos qualitativos representaram 55 % (n = 11) na abordagem metodológica. Emergiram da análise as categorias temáticas "elementos psíquicos e emocionais", "recursos humanos, materiais e infraestrutura", "relações interpessoais", "insatisfação", "violência no local de trabalho" e "sobrecarga". Conclusões: O ambiente precário na APS impacta negativamente os enfermeiros e os cuidados a população. Melhorias na infraestrutura, na equipe e nas condições de trabalho são essenciais para garantir a qualidade no cuidado.

https://doi.org/10.5294/aqui.2024.24.37

Influence of low and medium intake supplements in the growing phase of steers grazing in the tropical pasture and finished in feedlot
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Missio, Regis Luis

; Souza, Saimon de Souza e

; Paris, Wagner

; Cavazzana, Jefferson Felipe

; Severo, Marcelo Machado

; Severo, Igor Kieling

; Poggere, Julia Maria

; Costa, Olmar Antônio Denardin

; Borquis, Rusbel Raul Aspilcueta

; Menezes, Luis Fernando Glasenapp de

Ciência Rural

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2024, Volume 54 N. 5 elocation e20220661

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT: The objective was to evaluate the animal production and ingestive behavior of the steers fed different supplements during the growth phase in Aruana grass, and the influence of this supplementation on production performance in feedlot phase. The treatments consisted of three supplements during the growing phase: mineral salt (0.12 g/kg of body weight - BW), low intake energy-protein supplement (1.26 g/kg of BW), and medium intake (3.76 g/kg of BW). Forage canopy characteristics, animal production, and animal behavior on pasture were evaluated in a completely randomized design with three replicates (paddocks). The titanium dioxide marker was used to determine the intake and apparent digestibility during the pasture phase. The production performance in feedlot was evaluated in a completely randomized design with eight replicates (animals). Twenty-four Aberdeen Angus steers (15 ± 1.5 months old; 364.8 ± 21.7 kg BW) were used. At the end of the growth phase the animals were confined and fed a single diet. Dry matter, crude protein, and neutral detergent fiber (NDF) contents of forage and intake were not influenced by the treatments. The average daily gain was higher for the medium intake supplement in pasture phase. The apparent digestibility of NDF (P = and chewing rate were higher for the medium intake supplement. The average daily gain and fat thickness of carcasses were higher for the medium intake supplement in the feedlot phase. The supplements of medium intake increase animal productivity during the growing phase on pastures and cattle’s finishing performance in intensive production systems.

RESUMO: O objetivo deste trabalho foi avaliar a produção animal e o comportamento ingestivo de novilhos alimentados com diferentes suplementos durante a fase de crescimento em capim Aruana, e a influência desta suplementação sobre o desempenho produtivo durante a fase de terminação em confinamento. Os tratamentos consistiram de três suplementos durante a fase de crescimento: sal mineral (0,12 g/kg do peso corporal - PC), suplemento energético-proteico de baixo consumo (1,26 g/kg do PC) e suplemento energético-proteico de médio consumo (3,76 g/kg do PC). As características do dossel forrageiro, a produção animal e o comportamento ingestivo em pastos de capim Aruana foram avaliados utilizando um delineamento inteiramente ao acaso com três repetições (piquetes). O marcador externo dióxido de titânio foi utilizado para determinar o consumo e digestibilidade aparente dos nutrientes na fase de pastagem. O desempenho em confinamento foi avaliado utilizando-se um delineamento inteiramente ao acaso com oito repetições (animais). Vinte e quatro novilhos Aberdeen Angus (15 ± 1,5 meses de idade; 364,8 ± 21,7 kg de peso corporal médio inicial) foram utilizados. Ao final da fase de recria, os animais experimentais foram confinados e alimentados com uma dieta única. Os teores de matéria seca, proteína bruta e fibra de detergente neutro (FDN) da forragem, bem como o consumo destas frações não foram alterados pelos tratamentos. O ganho médio diário foi superior para o suplemento de ingestão média na fase de pastagem. A digestibilidade da FDN e a taxa de ruminação na fase pastagem foram mais elevadas para o suplemento de média ingestão. O ganho médio diário e a espessura de gordura das carcaças foram mais elevados para o suplemento de ingestão média na fase de acabamento em confinamento. Suplementos de ingestão média aumentam a produtividade animal durante a fase de crescimento em pastagens e o desempenho em confinamento de bovinos provenientes de sistemas intensivos de produção.

https://doi.org/10.1590/0103-8478cr20220661

Nursing care protocol for critical users with tracheostomy under mechanical ventilation
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Lima, Fernando Conceição de

; Neves, Wagner Felipe dos Santos

; Dias, André Lucas de Lima

; Mendes, Clarissa Porfírio

; Simor, Alzinei

; Pimentel, Ingrid Magali de Souza

; Sonobe, Helena Megumi

; Santana, Mary Elizabeth de

Revista Brasileira de Enfermagem

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2024, Volume 77 N. 2 elocation e20230337

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

RESUMEN Objetivos: desarrollar y evaluar un protocolo de atención de enfermería a usuarios críticos con traqueostomía y ventilación mecánica. Métodos: estudio metodológico, desarrollado a través de dos fases, guiado por la herramienta de gestión 5W2H: I) caracterización del público objetivo y II) desarrollo tecnológico. Resultados: participaron de este estudio 34 profesionales de enfermería, quienes presentaron demandas educativas en relación al cuidado de usuarios críticos con traqueotomía, con énfasis en estandarizar los cuidados a través de un protocolo y realizar educación permanente. Consideraciones Finales: la creación y validación de nuevas tecnologías orientadas a este propósito han potenciado la participación de los profesionales de enfermería y su empoderamiento en las acciones microsectoriales y macrosectoriales de la institución de salud, por resaltar la necesidad de políticas públicas que garanticen la conducción de una línea de atención a usuarios con traqueotomía.

RESUMO Objetivos: desenvolver e avaliar um protocolo de cuidados de enfermagem para usuários críticos com traqueostomia em ventilação mecânica. Métodos: estudo metodológico, desenvolvido mediante duas fases, guiadas pela ferramenta gerencial 5W2H: I) caracterização do público-alvo e II) desenvolvimento da tecnologia. Resultados: participaram deste estudo 34 profissionais de enfermagem, que apresentaram demandas educacionais em relação aos cuidados com o usuário crítico com traqueostomia, com ênfase na padronização dos cuidados mediante um protocolo e realização de educação permanente. Considerações Finais: a criação e a validação de novas tecnologias voltadas para este fim potencializaram a participação dos profissionais de enfermagem e o seu empoderamento nas ações microssetoriais da instituição de saúde e nas ações macrossetoriais, por evidenciar a necessidade de políticas públicas que garantam a condução de uma linha de cuidado para usuários com traqueostomia.

ABSTRACT Objectives: to develop and assess a nursing care protocol for critically ill users with tracheostomy under mechanical ventilation. Methods: a methodological study, developed through two phases, guided by the 5W2H management tool: I) target audience characterization and II) technology development. Results: thirty-four nursing professionals participated in this study, who presented educational demands in relation to care for critical users with tracheostomy, with an emphasis on standardizing care through a protocol and carrying out continuing education. Final Considerations: the creation and validity of new technologies aimed at this purpose enhanced the participation of nursing professionals and their empowerment in the health institution’s microsectoral actions and in macrosectoral actions, highlighting the need for public policies that guarantee the conduct of a line of care for users with tracheostomy.

https://doi.org/10.1590/0034-7167-2023-0337

SOFRIMENTO EMOCIONAL VIVENCIADO POR PROFISSIONAIS DE ENFERMAGEM EM SITUAÇÃO DE CRISE SANITÁRIA
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Monteiro, Wagner Ferreira

; Ximenes, Vitória Miranda

; Silva, Denise Maria Guerreiro Vieira da

; Andrade, Lucas Lorran Costa de

; Lima, Kássia Janara Veras

; Ferreira, Darlisom Sousa

; Ramos, Flávia Regina Souza

Cogitare Enfermagem

Journal Metrics
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2024, Volume 29 elocation e92625

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

RESUMEN Objetivo: investigar las repercusiones emocionales que experimentaron los profesionales de enfermería durante la pandemia de COVID-19 en Manaos. Método: estudio descriptivo cualitativo. La recolección de datos se realizó de junio de 2020 a febrero de 2021, en la capital del estado de Amazonas, Brasil, a través de entrevistas semiestructuradas con profesionales de enfermería que trabajaban en la primera línea, codificadas con ayuda del programa ATLAS.ti 8.0 y analizadas según los preceptos del análisis de Redes Temáticas. Resultados: los 19 participantes eran enfermeros (68%) y técnicos/auxiliares de enfermería (32%). De la Red Temática Impactos Emocionales surgieron cuatro temas: cambios inesperados, mayor tensión, sufrimiento emocional y estrategias de apoyo psicosocial. Conclusión: las experiencias de los profesionales deben contribuir a la creación de iniciativas que promuevan y protejan la salud y las condiciones de trabajo de dichos profesionales, para garantizar la calidad de la atención que brindan.

RESUMO Objetivo: investigar as repercussões emocionais vivenciadas pelos profissionais de enfermagem durante o enfrentamento da pandemia de COVID-19 em Manaus. Método: estudo descritivo qualitativo. A coleta de dados ocorreu de junho de 2020 a fevereiro de 2021, na capital do estado do Amazonas, Brasil, por meio de entrevistas semiestruturadas com profissionais de enfermagem que atuaram na linha de frente, codificadas com o auxílio do programa ATLAS.ti 8.0 e analisadas segundo os preceitos da análise de Redes Temáticas. Resultados: os 19 participantes foram enfermeiros (68%) e técnicos/auxiliares de enfermagem (32%). Da Rede Temática Impactos Emocionais emergiram quatro temas: mudanças inesperadas, tensões ampliadas, sofrimento emocional e estratégias de suporte psicossocial. Conclusão: as experiencias vividas pelos profissionais devem ser subsídio para iniciativas que promovam e protejam a saúde desses profissionais, como também suas condições de trabalho para garantir a qualidade dos cuidados prestados.

ABSTRACT Objective: to investigate the emotional repercussions experienced by nursing professionals during the COVID-19 pandemic in Manaus. Method: qualitative descriptive study. Data collection took place from June 2020 to February 2021, in the Amazonas state capital, Brazil, through semi-structured interviews with nursing professionals who worked on the front line, coded with the aid of the ATLAS.ti 8.0 program and analyzed according to the precepts of Thematic Network Analysis. Results: the 19 participants were nurses (68%) and nursing technicians/assistants (32%). Four themes emerged from the Emotional Impacts Thematic Network: unexpected changes, increased tensions, emotional distress, and psychosocial support strategies. Conclusion: the professionals’ experiences should be used as a basis for initiatives to promote and protect their health, as well as their working conditions, in order to guarantee the quality of the care they provide.

https://doi.org/10.1590/ce.v29i0.92625

10.

Influence of Rail Metallurgy and Welding Parameterization on the Quality of Flash Butt Welds Done with Mobile Equipment
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Alves, Luiz Henrique Dias

; Pereira, Henrique Boschetti

; Echeverri, Edwan Anderson Ariza Rezende, Iran José Souza, Ricardo Flores, Wagner Duarte Tressia, Gustavo Goldenstein, Hélio

Materials Research

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2024, Volume 27 elocation e20230566

Abstract: En | Text: En | PDF: En

The aim of this study was to assess the impact of rail metallurgy, focusing on segregations and chemical composition, and welding parameterization on the quality and susceptibility of welds to defects and failures induced by mobile flash butt welding (FBW). Ten welds were performed using two different welding programs, with varying heat input, on premium rails sourced from the same batch. The welds underwent full metallurgical characterization of the weld and HAZ, including hardness profile, mechanical testing, and micrographic analysis of the head, web, and foot regions. The results showed that both the HAZ dimensions and the hardness profile are influenced by weld parameterization. All welds fabricated by the lower heat input program, small islands of martensite and retained austenite (MA) were observed only in the foot region, close to the weld line. From the higher heat input program, only one weld showed islands of MA. Localized chemical analysis indicated that the formation of these islands is linked to microsegregation, especially of Mn and Cr present in the rail. metallurgy composition FBW. FBW . (FBW) programs batch testing head web regions program MA (MA region line microsegregation (FBW

https://doi.org/10.1590/1980-5373-mr-2023-0566

11.

SOFRIMENTO EMOCIONAL VIVENCIADO POR PROFISSIONAIS DE ENFERMAGEM EM SITUAÇÃO DE CRISE SANITÁRIA
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Monteiro, Wagner Ferreira

; Ximenes, Vitória Miranda

; Silva, Denise Maria Guerreiro Vieira da

; Andrade, Lucas Lorran Costa de

; Lima, Kássia Janara Veras

; Ferreira, Darlisom Sousa

; Ramos, Flávia Regina Souza

Cogitare Enfermagem

Journal Metrics
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2024, Volume 29 elocation e92625

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/ce.v29i0.92625

12.

Chromoblastomycosis in Brazil: A review of 450 published cases Brazil 45 4
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Barbosa, Layala Stefane de Paula

; Souza, Yury Raphaell Coringa de

; Sasaki, Caroline Suemi

; Santos, Daniel Wagner dos

; Rossato, Luana

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00205-2024

Abstract: En | Text: En | PDF: En

ABSTRACT Chromoblastomycosis is a skin infection caused by melanized fungi that primarily affects rural workers. This study aimed to analyze the clinical and epidemiological manifestations of chromoblastomycosis in Brazil through an extensive literature review. A review of case reports or series of cases in English and Portuguese was conducted using the SciELO, LILACS, SCOPUS, PubMed, and Web of Science databases from 1963 to 2022. A total of 46 articles involving 450 patients were identified, among which, 83.1% were male rural workers with a mean age of 52.2 years. The clinical manifestations were most commonly observed in the lower extremities (78.7%). The most frequent clinical presentations of the disease were verrucous lesions and plaques. Fonsecaea and Rhinocladiella spp. were the most common agents responsible for chromoblastomycosis. Most cured cases were treated with itraconazole, either as monotherapy or in combination with other antifungals, surgery, or cryosurgery. Chromoblastomycosis affects hundreds of rural workers in Brazil, leading to financial disabilities as well as personal and family losses. It is essential to prioritize epidemiological surveillance and ensure the early diagnosis of this disease to reveal its true prevalence, guide resource allocation, improve diagnosis, ensure early treatment, and implement preventive measures. SciELO LILACS SCOPUS PubMed 196 2022 4 45 identified which 831 83 1 83.1 522 52 2 52. years 78.7%. 787 78.7% . 78 7 (78.7%) plaques spp itraconazole antifungals surgery cryosurgery losses prevalence allocation treatment measures 19 202 8 83. 5 78.7 (78.7% 20 78. (78.7 (78. (78 (7 (

https://doi.org/10.1590/0037-8682-0132-2024

13.

Day-Ahead Operational Planning of Isolated Microgrids Considering Over/Underestimation Costs for Solar and Wind Power Generation and Battery Degradation Costs DayAhead Day Ahead OverUnderestimation Over Underestimation
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Souza, Wagner Felipe Santana

; Oliveira, Ádamo Henrique Rocha de

; Lara, Carla Eduarda Orlando de Moraes de

; Kuiava, Roman

; Leandro, Gideon Villar

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24241072

Abstract: En | Text: En | PDF: En

Abstract This paper proposes a methodology for the day-ahead operational planning of isolated microgrids equipped with renewable distributed generation based on solar photovoltaic and wind generation systems, energy storage systems, and diesel generation as backup power sources. As one of the main contributions of this paper, the proposed methodology is based on optimal power flow (OPF), considering cost minimization as the objective function that combines probabilistic costs of the renewable distributed generation systems with the determinist cost associated with the degradation of the battery bank. In addition, the cost of fuel consumption associated with the diesel generator is also considered. The costs associated with the renewable distributed generation are modeled by probability density functions, where a reserve cost for overestimation and a penalty cost for underestimation of the output power from these renewable sources are adopted. Hence, the proposed OPF avoids the over/underestimation of the available day-ahead solar and wind generations. The differential evolution optimization technique was used to solve the proposed OPF formulation and to obtain a minimum cost of operation considering the deterministic load profile for the operation of the microgrid under study. The proposed formulation was tested for different solar photovoltaic and wind generation scenarios in a microgrid in Lençóis Island, Brazil, another important contribution of the paper. The obtained results showed that the considered microgrid's day-ahead planning is sensitive to climatic conditions that impact the generation scenario and minimize long-term operating costs. dayahead day ahead OPF, , (OPF) bank addition functions adopted Hence overunderestimation over generations study Island Brazil s longterm long term (OPF

https://doi.org/10.1590/1678-4324-2024231072

14.

Avaliação de programa de residência em medicina de família e comunidade pela ótica dos médicos residentes
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Guimarães, Samuel Carvalho

; Guimarães, Emanoella Pessoa Angelim

; Souza Júnior, Otenberg Nogueira de

; Machado, Maria de Fátima Antero Sousa

; Freitas, Roberto Wagner Júnior Freire de

; Nuto, Sharmênia de Araújo Soares

Revista Brasileira de Educação Médica

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2024, Volume 48 N. 4 elocation e098

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A residência médica (RM) é considerada acadêmica e profissionalmente o método padrão ouro no ensino de médicos egressos da universidade. O Programa Integrado de Residência em Medicina de Família e Comunidade (PIRMFC) de Fortaleza, no Ceará, reúne os programas da Universidade Federal do Ceará, da Escola de Saúde Pública do Ceará e da prefeitura, e é o primeiro do gênero em larga escala, contando com cerca de 70 residentes na primeira edição, implantado em uma capital, paralelamente ao processo de implantação da rede de serviços da Estratégia Saúde da Família (ESF) pela prefeitura. Objetivo: Este estudo teve como objetivo avaliar um PIRMFC a partir da ótica dos residentes. Método: Trata-se de uma pesquisa exploratória, com abordagem qualitativa, utilizando o modelo de Kirkpatrick no seu primeiro nível: reação e satisfação dos residentes. A coleta de dados foi realizada com a participação de 18 residentes (R2) em cinco grupos focais, no segundo semestre de 2020. Aplicaram-se também questionários com perguntas fechadas para caracterização da amostra, seguidas de questões de múltipla escolha graduadas em escala Likert. Os dados qualitativos foram examinados pela técnica de análise temática, e os quantitativos, por meio de frequências simples e percentuais. Resultado: Identificaram-se as seguintes categorias principais: estratégias de ensino-aprendizagem, avaliação do processo ensino-aprendizagem, produção de autonomia, transferência da formação para a prática, fragilidades e potencialidades da residência. Os residentes compreendem a responsabilidade que têm no atendimento médico diário, ainda que como aprendizes. Eles demonstram insegurança como sujeitos da formação, sentindo-se mais confortáveis quando são colocados no papel passivo. Contudo, os discentes do programa reconhecem a metodologia ativa de ensino-aprendizagem como adequada para o ensino de adultos, mas precisam que as estratégias estejam voltadas para a resolução de problemas comuns à prática profissional deles. Conclusão: O programa não conseguiu firmar bases para o engajamento dos residentes em algumas estratégias ativas simuladas de ensino-aprendizagem, como grupos tutoriais. É preciso valorizar as experiências e competências adquiridas heterogeneamente pelos residentes para compor momentos de equalização do aprendizado, buscando o protagonismo do aluno em vez da imposição de conhecimentos. Introdução RM (RM universidade (PIRMFC Fortaleza prefeitura 7 edição capital ESF (ESF Objetivo Método Tratase Trata se exploratória qualitativa nível 1 R2 R (R2 focais 2020 Aplicaramse Aplicaram amostra Likert temática quantitativos percentuais Resultado Identificaramse Identificaram principais ensinoaprendizagem, ensinoaprendizagem aprendizagem, aprendizagem autonomia diário aprendizes sentindose sentindo passivo Contudo adultos deles Conclusão tutoriais aprendizado conhecimentos (R 202 20 2

ABSTRACT Introduction: Medical Residency (MR) is considered, both academically and professionally, the gold standard method in teaching university graduates. The Integrated Residency Program in Family and Community Medicine (PIRMFC) in Fortaleza-CE brings together the programs of Universidade Federal do Ceará, the School of Public Health of Ceará and the City Hall of Fortaleza and is the first of its kind on a large scale, with about 70 residents in the first edition, implemented in a capital city, concomitantly with the process of implementation of the Family Health Strategy (ESF) service network by the City Hall. Objective: To evaluate an Integrated Residency Program in Family and Community Medicine, from the perspective of resident doctors. Method: This is an exploratory study, with a qualitative approach, using the Kirkpatrick model in its first level, reaction and satisfaction of residents. Data collection was carried out with the participation of 18 residents (R2) in five Focus Groups, in the second half of 2020. Questionnaires with closed questions were also applied to characterize the sample, followed by multiple-choice questions graded on a Likert scale. The qualitative data were analyzed by the Thematic Analysis technique and quantitative data through simple frequency and percentage. Results: The following main categories were identified: Teaching-learning strategies, Evaluation of the teaching-learning process, Production of autonomy, Transfer of training into practice, Weaknesses and Potentialities of the residency. Residents understand the responsibility they have in daily medical care, even if they are apprentices. They felt insecure as training subjects, feeling more comfortable when they are placed in the passive role. On the other hand, the program students recognize the active teaching-learning methodology as adequate for teaching adults but need strategies to be used to solve common problems in their professional practice. Conclusion: The Program was not able to establish the basis for the engagement of residents in some simulated active teaching-learning strategies, such as Tutorial Groups. It is necessary to value the experiences and competences heterogeneously acquired by the residents to constitute moments of equalization of learning, seeking the student’s protagonism instead of the imposition of knowledge. Introduction MR (MR considered professionally graduates PIRMFC (PIRMFC FortalezaCE CE scale 7 edition city ESF (ESF Objective doctors Method study approach level 1 R2 R (R2 Groups 2020 sample multiplechoice multiple choice percentage Results identified Teachinglearning Teaching learning teachinglearning autonomy practice residency care apprentices subjects role hand Conclusion student s knowledge (R 202 20 2

https://doi.org/10.1590/1981-5271v48.4-2023-0142

15.

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila Rêgo, Jozelia Machado, Ketty Lysie Libardi Lira Miyamoto, Samira Tatiyama Burian, Ana Paula Neves Dias, Laiza Hombre Pretti, Flavia Zon Batista, Danielle Cristina Filgueira Alves Mill, José Geraldo Oliveira, Yasmin Gurtler Pinheiro de Gadelha, Carolina Strauss Estevez Gouveia, Maria da Penha Gomes Moulin, Anna Carolina Simões Souza, Bárbara Oliveira Aguiar, Laura Gonçalves Rodrigues Vieira, Gabriel Smith Sobral Grillo, Luiza Lorenzoni Lima, Marina Deorce de Pasti, Laís Pizzol Surlo, Heitor Filipe Faé, Filipe Moulaz, Isac Ribeiro Macabú, Mariana de Oliveira Ribeiro, Priscila Dias Cardoso Magalhães, Vanessa de Oliveira Aguiar, Mariana Freitas de Biegelmeyer, Erika Peixoto;, Flávia Maria Matos Melo Campos Kayser, Cristiane Souza, Alexandre Wagner Silva de Castro, Charlles Heldan de Moura Ribeiro, Sandra Lúcia Euzébio Telles, Camila Maria Paiva França Bühring, Juliana Lima, Raquel Lima de Santos, Sérgio Henrique Oliveira Dos Dias, Samuel Elias Basualto Melo, Natália Seixas de Sanches, Rosely Holanda da Silva Boechat, Antonio Luiz Sartori, Natália Sarzi Hax, Vanessa Dória, Lucas Denardi Rezende, Rodrigo Poubel Vieira de Baptista, Katia Lino Fortes, Natália Rodrigues Querido Melo, Ana Karla Guedes de Melo, Tâmara Santos Vieira, Rejane Maria Rodrigues de Abreu Vieira, Adah Sophia Rodrigues Kakehasi, Adriana Maria Tavares, Anna Carolina Faria Moreira Gomes Landa, Aline Teixeira de Costa, Pollyana Vitoria Thomaz da Azevedo, Valderilio Feijó Martins-Filho, Olindo Assis Peruhype-Magalhães, Vanessa Pinheiro, Marcelo de Medeiros Monticielo, Odirlei André Reis-neto, Edgard Torres Dos Ferreira, Gilda Aparecida Souza, Viviane Angelina de Teixeira-Carvalho, Andréa Xavier, Ricardo Machado Sato, Emilia Inoue Valim, Valeria Pileggi, Gecilmara Salviato Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

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