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ABSTRACT: This study assessed the efficacy of an intra-articular injection of allogeneic adipose tissue-derived from mesenchymal stem cells (AD-MSCs) for the treatment of hip dysplasia in dogs. The study group included 12 otherwise healthy dogs of different breeds, ages, weights, and degrees of hip dysplasia diagnosed using radiography. An orthopedic assessment was performed on all dogs before and at 30, 60, and 90 days after infusion of AD-MSCs(2 × 106cells). On the same days, each dog’s owner answered a questionnaire based on theHelsinkiChronic Pain Index. The data were converted to ordinal data based on the score for each variable, and the Friedman test for multiple comparisons was used to verify the results. Compared with the corresponding values on day 0, orthopedic and gait assessments and owners’ reported pain indexes improved over the 90-day observation period. These results suggested that treatment with allogeneic AD-MSCs significantly reduced the clinical signs associated with hip dysplasia during the study period. However, long-term studies are needed to determine the optimal therapeutic protocol for routine clinical use of AD-MSCs in hip dysplasia.

RESUMO: O objetivo deste estudo foi avaliar a eficácia clínica da aplicação intra-articular de células-tronco mesenquimais alógenas derivadas do tecido adiposo (AD-CTM) no tratamento de cães portadores de osteoartrite secundária a displasia do coxofemoral (DCF). Doze cães de ambos os sexos, diferentes raças, idades e peso, portadores de graus variados de DCF comprovada em radiografia e livres de quaisquer outras alterações clínicas ou ortopédicas, foram utilizados no estudo. Todos os cães foram submetidos a avaliação ortopédica nos dias 0, 30, 60 e 90 após aplicação de AD-CTM na dose de 2 x 106. Além disso, os tutores preencheram a um questionário, baseado no Índice de dor crônica de Helsinque (IDCH) nos mesmos intervalos. Em comparação com o dia 0, observou-se melhora significativa na avalição em locomoção e físico-ortopédica assim como na avaliação dos tutores pelo IDCH ao longo dos 90 dias. Os resultados permitem inferir que as AD-CTM alógenas contribuíram significativamente para a redução dos sinais clínicos comumente associados a DCF durante o período de estudo. Entretanto, há necessidade de estudos de longo prazo para melhor determinação de protocolos terapêuticos baseados no uso de AD-CTM na rotina clínica.

https://doi.org/10.1590/0103-8478cr20220658

Pediatric COVID-19: clinical and epidemiological data of 1303 cases in a general hospital in Brazil
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Bain, Vera

; Abramczyk, Marcelo Luiz

; Costa, Ricardo Luiz Soares

; Paixão, Milena Ribeiro

; Souza Junior, José Leão de

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2023031

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: This study aimed to describe the clinical characteristics of the pediatric population with COVID-19 in an Emergency Department (ED) of a Brazilian general hospital. Methods: Epidemiological and clinical data of patients younger than 20 years old were collected from patients’ medical records from February 2020 to July 2021. Most of the epidemiological data described pertains to hospitalized patients. We also reviewed coinfections, treatment, and outcomes and compared the first and second waves of COVID-19. Results: We identified a total of 1303 episodes of SARS-CoV-2 infection. The median time from symptom onset to diagnosis was three days. Symptoms were present in 92.3% of the patients. The most common symptoms were fever (45.2%), nasal congestion/discharge (44.2%), and cough (39.4%). Chest radiography and tomography were performed in 7.7 and 3.3% of cases, with abnormal findings in 29.7 and 53.4%, respectively. Hospital admissions occurred in 3.5% of patients, mainly in the presence of comorbidities, in children under five years old and in those who presented to the ED during the first wave of COVID-19. Coinfection with a viral agent was identified in 20% of the 71 cases tested in this study, and a positive rapid test for Streptococcus pyogenes was found in 8% of the 174 cases tested, with no impact of these coinfections on hospitalization. Conclusions: We found that COVID-19 was a mild disease in most children in our study population, with most hospitalizations and readmissions occurring during the first wave of COVID-19.

RESUMO Objetivo: Este estudo teve como objetivo descrever as características clínicas da população pediátrica com COVID-19 no setor de emergência de um hospital geral brasileiro. Métodos: Os dados epidemiológicos e clínicos de pacientes idade inferior a 20 anos foram coletados dos prontuários dos pacientes de fevereiro de 2020 a julho de 2021. A maior parte dos dados epidemiológicos descritos refere-se a pacientes hospitalizados. Também foram revisados as coinfecções, o tratamento e os desfechos de internação e comparadas a primeira e a segunda ondas de COVID-19. Resultados: Foi identificado o total de 1.303 episódios de infecção por SARS-CoV-2. A mediana de tempo desde o início dos sintomas até o diagnóstico foi de três dias. Os sintomas estiveram presentes em 92,3% dos pacientes. Os sintomas mais comuns foram febre (45,2%), congestão/secreção nasal (44,2%) e tosse (39,4%). Radiografia e tomografia de tórax foram realizadas em 7,7 e 3,3% dos casos, com achados anormais em 29,7 e 53,4%, respectivamente. As internações hospitalares ocorreram em 3,5% dos pacientes, principalmente na presença de comorbidades, em crianças menores de cinco anos e naqueles que se apresentaram no pronto-socorro durante a primeira onda de COVID-19. Foi identificada coinfecção viral em 20% dos 71 casos testados e teste rápido positivo para Streptococcus pyogenes em 8% dos 174 casos testados, não havendo impacto dessas coinfecções quanto à internação hospitalar. Conclusões: Observamos que a COVID-19 foi uma doença leve na maioria das crianças de nossa população, com a maior parte das hospitalizações e readmissões ocorrendo durante a primeira onda de COVID-19.

https://doi.org/10.1590/1984-0462/2024/42/2023031

[SciELO Preprints] - Cardiovascular Statistics – Brazil 2023
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Oliveira, Gláucia Maria Moraes de Brant, Luisa Campos Caldeira Polanczyk, Carisi Anne Malta, Deborah Carvalho Biolo, Andreia Nascimento, Bruno Ramos Souza, Maria de Fatima Marinho de Lorenzo, Andrea Rocha De Fagundes Júnior, Antonio Aurélio de Paiva Schaan, Beatriz D. Silva, Christina Grüne de Souza e Castilho, Fábio Morato de Cesena, Fernando Henpin Yue Soares, Gabriel Porto Xavier Junior, Gesner Francisco Barreto-Filho, Jose Augusto Soares Passaglia, Luiz Guilherme Pinto-Filho, Marcelo Martins Machline-Carrion, M. Julia Bittencourt, Marcio Sommer Pontes Neto, Octavio M. Villela, Paolo Blanco Teixeira, Renato Azeredo Stein, Ricardo Sampaio, Roney Orismar Gaziano, Thomaz A. Perel, Pablo Roth, Gregory A. Ribeiro, Antonio Luiz Pinho

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Publication date: 2023-12-14

Abstract: En Pt

The publication Cardiovascular Statistics – Brazil aims to provide an annual compilation of data and research on the epidemiology of CVDs in Brazil.  The report integrates official statistics from the Brazilian Ministry of Health and other governmental entities alongside data from the GBD project, coordinated by the IHME at the University of Washington. Additionally, it incorporates data derived from various sources and scientific studies, including cohorts and registries, that relate to CVDs and their associated risk factors. This publication is intended for a wide range of individuals, including researchers, clinicians, patients, healthcare policymakers, media professionals, the general public, and other interested parties seeking extensive national data about heart disease and stroke.  Volunteer researchers from various Brazilian universities and research institutions carry out the project. The group is led by a five-member steering committee (ALPR, CAP, DCM, GMMO, and LCCB). The Brazilian Society of Cardiology fully supports this initiative, and the project receives collaborative support from the GBD Brazil Network and an International Committee (GAR, PP, and TAG) from both the IHME/University of Washington (GAR) and the World Heart Federation (PP and TAG). 

A publicação Estatística Cardiovascular – Brasil tem por objetivo fornecer uma compilação anual dos dados e das pesquisas sobre a epidemiologia das DCV no Brasil.  Este documento integra as estatísticas oficiais do Ministério da Saúde do Brasil e outras entidades governamentais ao lado de dados do projeto GBD, coordenado pelo IHME da Universidade de Washington. Além disso, incorpora dados derivados de várias fontes e estudos científicos, inclusive coortes e registros, relacionados às DCV e fatores de risco associados. Esta publicação destina-se a um público variado, incluindo pesquisadores, clínicos, pacientes, formuladores de políticas de saúde, profissionais da mídia, o público em geral e todos aqueles que buscam dados nacionais abrangentes sobre DCV e acidente vascular cerebral. Pesquisadores voluntários de várias universidades e instituições de pesquisa brasileiros realizaram este projeto. O grupo é liderado por um comitê diretivo com cinco membros (ALPR, CAP, DCM, GMMO e LCCB). A Sociedade Brasileira de Cardiologia apoia integralmente esta iniciativa e o projeto recebe colaboração da Rede GBD Brasil1 e do GBD International Committee (GAR, PP e TAG) do IHME/Universidade de Washington (GAR) e da World Heart Federation (PP e TAG). 

https://doi.org/10.1590/SciELOPreprints.7707

Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023
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Almeida, André Luiz Cerqueira

; Melo, Marcelo Dantas Tavares de

; Bihan, David Costa de Souza Le

; Vieira, Marcelo Luiz Campos

; Pena, José Luiz Barros

; Del Castillo, José Maria

; Abensur, Henry

; Hortegal, Renato de Aguiar

; Otto, Maria Estefania Bosco

; Piveta, Rafael Bonafim

; Dantas, Maria Rosa

; Assef, Jorge Eduardo

; Beck, Adenalva Lima de Souza

; Santo, Thais Harada Campos Espirito

; Silva, Tonnison de Oliveira

; Salemi, Vera Maria Cury

; Rocon, Camila

; Lima, Márcio Silva Miguel

; Barberato, Silvio Henrique

; Rodrigues, Ana Clara

; Rabschkowisky, Arnaldo

; Frota, Daniela do Carmo Rassi

; Gripp, Eliza de Almeida

; Barretto, Rodrigo Bellio de Mattos

; Silva, Sandra Marques e

; Cauduro, Sanderson Antonio

; Pinheiro, Aurélio Carvalho

; Araujo, Salustiano Pereira de

; Tressino, Cintia Galhardo

; Silva, Carlos Eduardo Suaide

; Monaco, Claudia Gianini

; Paiva, Marcelo Goulart

; Fisher, Cláudio Henrique

; Alves, Marco Stephan Lofrano

; Grau, Cláudia R. Pinheiro de Castro

; Santos, Maria Veronica Camara dos

; Guimarães, Isabel Cristina Britto

; Morhy, Samira Saady

; Leal, Gabriela Nunes

; Soares, Andressa Mussi

; Cruz, Cecilia Beatriz Bittencourt Viana

; Guimarães Filho, Fabio Villaça

; Assunção, Bruna Morhy Borges Leal

; Fernandes, Rafael Modesto

; Saraiva, Roberto Magalhães

; Tsutsui, Jeane Mike

; Soares, Fábio Luis de Jesus

; Falcão, Sandra Nívea dos Reis Saraiva

; Hotta, Viviane Tiemi

; Armstrong, Anderson da Costa

; Hygidio, Daniel de Andrade

; Miglioranza, Marcelo Haertel

; Camarozano, Ana Cristina

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Siqueira, Maria Eduarda Menezes de

; Torreão, Jorge Andion

; Rochitte, Carlos Eduardo

; Felix, Alex

Arquivos Brasileiros de Cardiologia

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dec 2023, Volume 120 N. 12 elocation e20230646

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230646

AVALIAÇÃO EDUCACIONAL E QUALIDADE SOCIAL NAS EXPERIÊNCIAS DO BRASIL E VENEZUELA
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Pereira, Maria Simone Ferraz

; Silva, Marcelo Soares Pereira da

; Rivas, Samir José

; Santos, Laís Alice Oliveira

Cadernos CEDES

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dec 2023, Volume 43 N. 121 Pages 66 - 76

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O artigo reflete sobre a qualidade e a avaliação educacional no Brasil e na Venezuela, sobre as aproximações e os distanciamentos entre esses países, além de situar diferentes concepções de qualidade da educação no campo e sua relação com a construção de processos e de práticas educativas na perspectiva da formação integral dos sujeitos. Os marcos regulatórios de avaliação desses países nos levaram ao pressuposto de que as avaliações que induzem escolas a se autoavaliarem podem se constituir em instrumentos para produção de melhoria da educação pública, na perspectiva da qualidade social. Venezuela sujeitos pública social

ABSTRACT This article reflects on quality and educational assessment in Brazil and Venezuela and its focus is on the similarities and differences between these countries. In addition it also aims at different conceptions of rural education quality and its relationship within the building of educational processes and educational practices under the perspective of the integral training of the subjects involved. The assessment regulatory frameworks in these countries led us to the assumption that assessments that induce schools to self-assess can become tools for producing improvements in public education, under the perspective of social quality. involved selfassess self assess

https://doi.org/10.1590/cc278180

Equity program: strategies on clinical studies as an aggregating potential program
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Crusoe, Edvan de Queiroz

; Hallack Neto, Abrahão Elias

; Nantes, Deise Ferreira

; Ribeiro, Eduardo Flavio Oliveira

; Pinto, Fernando Monteiro Correia

; Bortolini, Jaisson Andre Pagnoncelli

; Maciel, James Farley Rafael

; Marques Junior, Jose Francisco Comenalli

; Corrêa, Lorena Costa

; Capra, Marcelo Eduardo Zanella

; Carvalho, Maria do Perpétuo Socorro Sampaio

; Melo, Nelcivone Soares de

; Quintas, Rafaela Vasques de Oliveira

; Carneiro, Thiago Xavier

; Laforga, Violete Petitto

; Cunha, Renato Luiz Guerino

Hematology, Transfusion and Cell Therapy

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dec 2023, Volume 45 N. 4 Pages 417 - 418

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.htct.2023.07.001

Muito além da “Lei de Wagner”: o pensamento econômico de Adolph Wagner Lei Wagner”
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Mello Filho, Marcelo Soares Bandeira de

Estudos Econômicos (São Paulo)

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dec 2023, Volume 53 N. 4 Pages 727 - 753

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O artigo procura interpretar elementos teóricos e metodológicos da obra de Wagner, tendo como referência três grandes conflitos da época em que viveu o autor: o debate teórico-metodológico sobre a existência e a relevância de uma teoria econômica completamente autônoma em relação às demais ciências humanas; o conflito em torno da formação e do nível de desenvolvimento econômico de um país dos falantes de língua alemã e a “questão social” e os conflitos de classe ligados à urbanização e à industrialização. O autor advogou a atuação do Estado como meio para promoção do desenvolvimento econômico e da reforma social. Wagner desenvolveu um ponto de vista sofisticado acerca das relações entre poder público e mercados, o qual enfatizava a interdependência e a coevolução de Estados nacionais e economias nacionais. teóricometodológico teórico metodológico humanas questão social industrialização mercados

Abstract The article seeks to interpret theoretical and methodological elements of Wagner’s work with reference to three major conflicts of the time in which the author lived: the theoretical-methodological debate on the existence and relevance of an economic theory that is completely autonomous in relation to other human sciences; the conflict over the formation and level of economic development of a German-speaking country; the “social question” and class conflicts linked to urbanization and industrialization. The author advocated the role of the State as a promoter of economic development and social reform. Wagner developed a sophisticated point of view about the relationship between government and markets, which emphasized the interdependence and coevolution of national states and national economies. Wagners s lived theoreticalmethodological sciences Germanspeaking German speaking country question industrialization reform markets economies

https://doi.org/10.1590/1980-53575343msbm

Intracranial hemorrhages in patients with COVID-19: a systematic review of the literature, regarding six cases in an Amazonian population
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Lima, William de Sousa

; Soares, Marcelo Henrique Pereira

; Paschoal, Eric Homero Albuquerque

; Paschoal, Joelma Karin Sagica Fernandes

; Paschoal Jr., Fernando Mendes

; Bor-Seng-Shu, Edson

Arquivos de Neuro-Psiquiatria

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nov 2023, Volume 81 N. 11 Pages 989 - 999

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Coronavirus disease 2019 (COVID-19) has emerged as a public health emergency worldwide, predominantly affecting the respiratory tract. However, evidence supports the involvement of extrapulmonary sites, including reports of intracranial hemorrhages. Objective To describe six original cases and review the literature on intracranial hemorrhages in patients diagnosed with COVID-19 by molecular methods. Methods A systematic literature review was performed on MEDLINE, PubMed, and NCBI electronic databases to identify eligible studies. Of the total 1,624 articles retrieved, only 53 articles met the inclusion criteria. Results The overall incidence of intracranial hemorrhage in patients hospitalized for COVID-19 was 0.26%. In this patient group, the mean age was 60 years, and the majority were male (68%) with initial respiratory symptoms (73%) and some comorbidity. Before the diagnosis of hemorrhage, 43% of patients were using anticoagulants, 47.3% at therapeutic doses. The intraparenchymal (50%) was the most affected compartment, followed by the subarachnoid (34%), intraventricular (11%), and subdural (7%). There was a predominance of lobar over non-lobar topographies. Multifocal or multicompartmental hemorrhages were described in 25% of cases. Overall mortality in the cohort studies was 44%, while around 55% of patients were discharged from hospital. Conclusion Despite the unusual association, the combination of these two diseases is associated with high rates of mortality and morbidity, as well as more severe clinicoradiological presentations. Further studies are needed to provide robust evidence on the exact pathophysiology behind the occurrence of intracranial hemorrhages after COVID-19 infection.

Resumo Antecedentes A COVID-19 emergiu como uma emergência de saúde pública em todo o mundo, proporcionando lesão principalmente do trato respiratório. No entanto, várias evidências apontam para acometimento de sítios extrapulmonares, incluindo relatos de hemorragias intracranianas. Objetivo Descrever seis casos originais e revisar a literatura sobre hemorragias intracranianas em pacientes com diagnostico de COVID-19 por métodos moleculares. Métodos A revisão sistemática da literatura foi feita nas bases de dados eletrônicas da MEDLINE, PubMed e NCBI para identificar os estudos elegíveis. Do total de 1.624 artigos recuperados, apenas 53 artigos preencheram os critérios de inclusão. Resultados A incidência geral de hemorragia intracraniana nos pacientes internados por COVID-19 foi de 0,26%. A média de idade foi de 60 anos, e a maioria dos pacientes era do sexo masculino (68%) com sintomas respiratórios iniciais (73%) e alguma comorbidade. Antes do diagnóstico de hemorragia, 43% estavam em uso de anticoagulantes, 47,3% destes em doses terapêuticas. O compartimento mais acometido foi o intraparenquimatoso (50%), seguido do subaracnoideo (34%), intraventricular (11%) e subdural (7%). Houve predomínio de topografias lobares sobre as não-lobares. Hemorragias multifocais ou multicompartimentais foram descritas em 25% dos casos. A mortalidade geral nos estudos de coorte foi de 44%, enquanto houve alta hospitalar em cerca de 55% dos pacientes. Conclusão Apesar da associação incomum, a combinação dessas doenças está relacionada com altas taxas de mortalidade e morbidade, bem como apresentações clínico-radiológicas mais graves. Mais estudos são necessários para oferecer evidências robustas sobre a fisiopatologia exata por trás da ocorrência de hemorragias intracranianas após infecção por COVID-19.

https://doi.org/10.1055/s-0043-1772834

Computed tomography evaluation of alterations in the masticator space due to invasion by malignant head and neck neoplasms
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Campinhos, Mariana Luiza Bittencourt

; Curioni, Otavio Alberto

; Soares, Aldemir Humberto

; Marcucci, Marcelo

Radiologia Brasileira

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sep 2023, Volume 56 N. 5 Pages 275 - 281

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective: To evaluate alterations in the masticator space due to the dissemination of malignant neoplasms originating from the tonsillar fossa, retromolar trigone, maxillary sinus, or nasopharynx, using computed tomography (CT), as well as to correlate the presence of trismus with the CT findings and the dimensions of the tumor. Materials and Methods: We evaluated the medical records of 65 patients with malignant tumors in the regions described. The images were analyzed by two physician examiners, working independently, who were blinded to the clinical data. In the evaluation of the masticator space, the following parameters were considered: symmetry with the contralateral space; obliteration of the fat plane, retromolar trigone, or pharyngeal space; edema/atrophy of the medial or lateral pterygoid muscles; and destruction of the mandibular ramus. Results: Obliteration of the fat plane was found in 69.2% of the patients. Asymmetry, edema/atrophy, and bone destruction were detected in 27.7%, 26.2%, and 20.0% of the patients, respectively. Trismus was identified in 15.4% of the patients. Of the patients with trismus, 90.0% had stage T4 tumors, compared with only 43.8% of those without trismus. Trismus was 11.6 times more common among the patients with stage T4 tumors than among those with lower-stage tumors. Neoplasms of the tonsillar fossa and retromolar trigone collectively accounted for 95.0% of the cases. The CT scans showed edema/atrophy of the pterygoid muscles in 60.0% of the patients with trismus and in 21.8% of those without. An association was observed between T4 tumor stage and edema/atrophy of the pterygoid muscles. In addition, the risk of trismus was 5.4 times higher among the patients with stage T4 tumors. Conclusion: In our patient sample, the most common finding was obliteration of the fat plane, followed by asymmetry and edema/atrophy. Most of the patients with T4 tumors had trismus, together with edema/atrophy of the pterygoid muscles.

Resumo Objetivo: Avaliar, por meio de tomografia computadorizada, alterações do espaço mastigador (EM) decorrentes de disseminação de neoplasias malignas originárias da loja tonsilar, trígono retromolar, seio maxilar e nasofaringe, e correlacionar presença de trismo com achados tomográficos e dimensões do tumor. Materiais e Métodos: Foram selecionados prontuários de 65 pacientes portadores de tumores malignos nas regiões descritas. A análise das imagens foi realizada por dois examinadores médicos, separadamente, sem o conhecimento das informações clínicas. Na avaliação do EM, foram considerados: simetria com o EM contralateral; obliteração do plano gorduroso, do trígono retromolar e do espaço faríngeo; edema e/ou atrofia dos músculos pterigóideos medial e lateral; destruição do ramo da mandíbula. Resultados: Foram observados obliteração do plano gorduroso em 69,2% dos pacientes, assimetria em 27,7%, espessamento/atrofia em 26,2% e destruição óssea em 20,0%. Presença de trismo foi encontrada em 15,4% dos pacientes. Na associação entre dimensão do tumor e trismo, foram observados trismo em 90,0% dos tumores em estágio T4, enquanto a porcentagem de tumores em estágio T4 sem trismo foi de 43,8%. Pacientes com tumores T4 apresentaram 11,6 vezes mais trismo que os dos demais estágios. Neoplasias da loja tonsilar e trígono retromolar perfizeram 95,0% dos casos. Em 60,0% dos pacientes com trismo havia edema e/ou atrofia dos músculos pterigóideos na tomografia computadorizada e em 21,8% nos sem trismo. Observou-se associação entre tumores T4 e edema e/ou atrofia dos músculos pterigóideos e 5,4 vezes mais chance de apresentarem trismo. Conclusão: A maioria dos pacientes apresentou obliteração do plano gorduroso, seguido de assimetria e espessamento/atrofia. O trismo estava presente na maioria dos pacientes T4 com espessamento/atrofia dos músculos pterigóideos.

https://doi.org/10.1590/0100-3984.2023.0024-en

10.

Nitrogen and phosphorus fertilization in upland rice in the municipality of Humaitá at Amazonas State
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Soares, Charle da Cunha

; Pereira, Carlos Eduardo

; Silva, Douglas Marcelo Pinheiro da

; Kikuti, Hamilton

Revista Ceres

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aug 2023, Volume 70 N. 4 Pages 117 - 123

Abstract: En | Text: En | PDF: En

ABSTRACT The fertilization management can contribute to a better agronomic performance of rice (Oryza sativa L.) plants in upland conditions. Thus, the objective in this study was to evaluate the development of rice plants fertilized with different doses of nitrogen and phosphorus in upland soil. The experiment was conducted in a greenhouse using pots containing soil collected in the soil top layer of a plinthic alitic Haplic Cambisol. The design was completely randomized with a 4 x 4 factorial scheme, corresponding to 0 (zero), 150, 300 and 450 kg ha-1 of phosphorus and 0 (zero), 100, 200 and 300 kg ha-1 of nitrogen. Plant height, shoot dry matter, grain weight and number of tillers were evaluated. Fertilization with nitrogen and phosphorus positively affects the growth and development of rice plants in Humaitá, Amazonas state, grown in upland soil up to doses between 200 and 300 kg ha-1 of N and around 300 kg ha-1 of P2O5, in a plinthic alitic Haplic Cambisol.

https://doi.org/10.1590/0034-737x202370040015

11.

Fracture in Irradiated Rat Femur: A Description of an Experimental Model and Evaluation of its Effectiveness
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Soares, Cláudio Beling Gonçalves

; Araújo, Ivana Duval de

; Teixeira, Luiz Eduardo Moreira

; Michelin, Márcia Antoniazi

; Machado, Carla Jorge

; Silveira, Marcelo Peixoto

Revista Brasileira de Ortopedia

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aug 2023, Volume 58 N. 4 Pages 653 - 658

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective We aim to describe an experimental model for studying femoral fractures in rats after exposure to ionizing radiation, demonstrating a way to apply a substance for analysis, the method for patterning fracture and irradiation, and how to evaluate its effectiveness based on radiographic studies. Methods We used 24 rats divided into 2 groups of 12 animals each. The STUDY group was exposed to ionizing radiation and treated with saline solution, and the CONTROL group was not exposed to radiation and was treated with saline solution. All animals were subjected to standardized fracture of the right femur that was fixed with intramedullary wire. The efficiency of the bone union was assessed by radiographic exam. Results Fracture healing was more efficient in bones not exposed to ionizing radiation (p = 0.012). All fractures met the criteria of being simple, diaphyseal, transverse or short oblique. Conclusion The experimental model presented is an efficient alternative for the study of fractures in irradiated bones in rats.

Resumo Objetivo Nosso objetivo é descrever um modelo experimental para estudo de fraturas de fêmur em ratos após exposição a radiação ionizante, demonstrando uma forma de aplicação de uma substância para análise, o método de padronização de fratura e irradiação e a forma de avaliação de sua eficácia com base em estudos radiográficos. Métodos Utilizamos 24 ratos divididos em dois grupos de 12 animais cada. O grupo ESTUDO foi exposto à radiação ionizante e tratado com soro fisiológico, enquanto o grupo CONTROLE não foi exposto à radiação e foi tratado com soro fisiológico. Todos os animais foram submetidos à fratura padronizada do fêmur direito e sua fixação com fio intramedular. A eficácia da consolidação óssea foi determinada por exame radiográfico. Resultados A cicatrização de fraturas foi mais eficiente em ossos não expostos à radiação ionizante (p = 0,012). Todas as fraturas atenderam aos critérios de serem simples, diafisárias, transversas ou oblíquas curtas. Conclusão O modelo experimental apresentado é uma boa alternativa para o estudo de fraturas em ossos irradiados em ratos.

https://doi.org/10.1055/s-0042-1758359

12.

[SciELO Preprints] - Target fishing and molecular modeling of nitroheteroaylchalcones with potent antituberculosis activity
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Gomes, Marcelo do Nascimento Sousa, Graziela Fernanda Souza, Rafael Junio Cardoso, Bruce Soares

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Publication date: 2023-06-06

Abstract: En Pt

Computer-aided drug planning strategies have contributed to the research and development of new anti-tuberculosis (TB) drugs to avoid resistance and reduce treatment time and the number of drugs used in therapy. The aim of work was to carry out a docking study to identify the possible mechanism of action of the hits LabMol73, 84, 86 and 93 previously tested in the Microplate Assay Blue Alamar (MABA), Low Oxygen Recovery Assay (LORA) assays in sensitive strains from M.tb. H37Rv and resistant to the standard drugs rifampicin and isoniazid, due to the promising inhibitory result against these strains, suggesting a different mechanism of action from existing drugs. The reverse virtual screening was performed on the Pharmmapper platform, which identifies targets by pharmacophoric model. The most promising targets have been validated. The DM was performed in the OpenEye Maestro program for analysis of poses and energy score. Sixteen targets M.tb. H37Rv were identified and only nine demonstrated viability for computational testing. The most promising results were observed in the mycolic acid cyclopropane synthase (PDB:1L1E) and pantothenate synthetase (PDB:1N2B) targets. Since, in the target 1L1E score results obtained were between -6.998 to -7.767 kcal/mol. In the 1N2B target the results were between -6.421 to -7.293 kcal/mol, presenting themselves as the most promising targets due to their similar score scores between the two targets suggesting that the mechanism of action may be the inhibition of one of these targets. These targets proved to be promising for elucidating the mechanism of action of the analyzed nitro heteroaryl chalcones, as they corroborate the assay against resistant strains, demonstrating that standard drugs have activity against other targets and also because mycolic acid and pantothenate are directly linked to virulence and resistance of M.tb. H37Rv.

https://doi.org/10.1590/SciELOPreprints.6188

13.

Overweight and obesity among Brazilian healthcare university students: prevalence and associated factors
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de Faria Filho, Humberto Carlos

; Garcez, Anderson

; da Costa, Juvenal Soares Dias

; Ramos, Marcelo

; Paniz, Vera Maria Vieira

Archives of Endocrinology and Metabolism

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jun 2023, Volume 67 N. 3 Pages 416 - 426

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: Obesity is an important factor for cardiovascular and metabolic events. Thus, this study aimed to assess the prevalence of overweight/obesity and the associated factors among healthcare university students. Materials and methods: A cross-sectional university-based study of 2,245 healthcare university students in the Midwest region of Brazil was conducted in 2018. Overweight and obesity were defined as body mass index (BMI) ≥ 25 kg/m2 and BMI ≥ 30 kg/m2, respectively. Demographic, socioeconomic, behavioral, family and comorbidities characteristics were investigated. Poisson regression was used for the multivariable analysis. All analysis was stratified by sex. Results: The mean age of the sample was 22.7 years (standard deviation = 4.1) and 69.5% of the students was female. The prevalence of overweight and obesity were 13.9% (95% confidence interval [CI]: 12.2-15.6) and 4% (95% CI: 3.0-4.9) for women and 34.5% (95% CI: 30.9-38.1) and 11.3% (95% CI: 8.9-13.6) for men, respectively. After multivariate adjustment, the prevalence of overweight/obesity was at least 70% higher in female students aged 24 years or older (prevalence ratio [PR] = 1.73; 95% CI: 1.24-2.41) and those who smoke (PR = 1.95; 95% CI: 1.66-3.02). Additionally, female students with a family history of obesity (PR = 2.01; 95% CI: 1.46-2.77) or with two or three comorbidities (PR = 2.09; 95% CI: 1.43-3.04) exhibited a significantly higher probability for overweight/obesity. Similar findings were observed in male students, but with smaller effect sizes. Conclusion: This study revealed a high prevalence of overweight/obesity among healthcare university students, especially in men. It was related to the socio-demographic and family characteristics rather than behavioral factors.

https://doi.org/10.20945/2359-3997000000602

14.

Soybean performance in succession to the intercropping of corn with marandu grass and pigeonpea in an integrated agricultural production system
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Pereira, Roseana Ramos

; Garcia, Izabela Militão

; Modesto, Viviane Cristina

; Sekiya, Bianca Midori Souza

; Soares, Deyvison de Asevedo

; Andreotti, Marcelo

Revista Ceres

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jun 2023, Volume 70 N. 3 Pages 72 - 80

Abstract: En | Text: En | PDF: En

ABSTRACT Integrated agricultural production systems have been improved with the introduction of Urochloa grasses aiming at obtaining straw for a no-tillage system (NTS) and the increase of legumes, which promote physicochemical improvements in soils and guarantee intensification and sustainability of production. This study aimed to evaluate the agronomic traits and yield of soybean in succession to the intercropping of corn with marandu grass and/or pigeonpea in five populations of plants harvested for silage production. The experiment was carried out in the Cerrado region of Selvíria, MS, Brazil, during the 2016/17 and 2017/18 agricultural years, in an Oxisol. The experimental design consisted of randomized blocks, with four replications. The treatments were arranged in a 2×5 factorial scheme, consisting of off-season corn intercropped with pigeonpea (Cajanus cajan (L.) Millsp.) and off-season corn intercropped with marandu grass (Urochloa brizantha) and pigeonpea, in addition to five sowing densities (0, 6, 12, 18, and 24 seeds m-1). Soybean was planted in succession aiming to evaluate the effect of remaining straw on crop performance. Soybean grown in succession to the triple intercropping of corn with marandu and pigeon pea shows increased productivity.

https://doi.org/10.1590/0034-737x202370030008

15.

Passeios de bicicleta, corridas esportivas: novos divertimentos na cidade de São Paulo (1896-1925)
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Lessa, Priscila Requião

; Soares, Carmen Lúcia

; Silva, Marcelo Moraes e

Topoi (Rio de Janeiro)

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jan 2023, Volume 24 N. 52 Pages 311 - 334

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT This paper investigates the introduction of bicycles in the city of São Paulo, aiming to comprehend how the first sporting races gradually accompanied simple rides. The selected sources for this research were newspapers and memoirs published between 1895 and 1925. The analysis of these documents indicated a relation between bicycles and the urban ideation emerging in the city of São Paulo during the selected timeframe, the unprecedented mobility and freedom this artefact provided for women, the role of clothing in a culture related to the bicycle, and a growing sportization of the act of riding bicycles in urban spaces. In conclusion, the presence of bicycles and races in São Paulo at the turn of the nineteenth century contributed substantially to creating athletic gestures and performances in individuals who interacted with bicycles.

RESUMEN El presente artículo pretende investigar la inserción de la bicicleta en la ciudad de São Paulo para comprender cómo los paseos simples fueron, poco a poco, acompañados de las primeras carreras deportivas. Para eso, se utilizaron como fuentes, periódicos de la época y memorias, en el período comprendido entre los años 1895 a 1925. El análisis de las fuentes constituidas indicó una relación entre la bicicleta y los ideales urbanos emergentes en la capital del Estado de São Paulo, la movilidad y la libertad sin precedentes que el artefacto permitió al género femenino, el papel del vestuario en una cultura relacionada con la bicicleta, así como una creciente deportividad de andar en bicicleta debido al crecimiento de la ciudad. Como conclusión, el artículo apunta que la presencia del artefacto de dos ruedas y de las carreras en São Paulo, en el paso del siglo XIX al XX, contribuyó significativamente para la formación de gestos atléticos y performativos en individuos que interactuaron con las bicicletas.

RESUMO O presente artigo pretende investigar a inserção da bicicleta na cidade de São Paulo para compreender como os singelos passeios foram, aos poucos, tendo a companhia das primeiras corridas esportivas. Para tanto foram utilizados como fontes jornais da época e memorialistas, no período delimitado entre os anos de 1895 a 1925. A análise das fontes constituídas indicou uma relação da bicicleta com o ideário urbano emergente na capital do estado de São Paulo, a mobilidade e liberdade inédita que o artefato possibilitou ao sexo feminino, o papel da vestimenta numa cultura relativa à bicicleta, bem como uma crescente esportivização do andar de bicicleta em virtude do crescimento da cidade. A título de conclusão, o artigo aponta que a presença do artefato de duas rodas e das corridas em São Paulo, na virada do século XIX para o XX, contribuiu significativamente na formação de gestualidades atléticas e performáticas nos indivíduos que interagiram com as bicicletas.

https://doi.org/10.1590/2237-101x02405214

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