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BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.

https://doi.org/10.1590/0074-02760220259

Is 12 months enough to reach function after athletes’ ACL reconstruction: a prospective longitudinal study
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Felix, Ellen Cristina Rodrigues

; Alonso, Angelica Castilho

; Brech, Guilherme Carlos

; Fernandes, Tiago Lazzaretti

; Almeida, Adriano Marques de

; Luna, Natalia Mariana Silva

; Soares-Junior, Jose Maria

; Baracat, Edmund Chada

; Hernandez, Arnaldo José

; Greve, Julia Maria D’Andrea

Clinics

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2022, Volume 77 elocation 100092

Abstract: En | Text: En | PDF: En

Abstract Context: Anterior Cruciate Ligament (ACL) injury is disabling in several sports because it causes knee instability and functional deficit. Usually, surgical treatments produce the best functional outcomes, however, sometimes they are not always able to fully restore stability and function. Objective: The objective of this study was to evaluate postural balance, muscle strength, and functional performance of young athletes with an ACL injury before and after ACL reconstruction. Design: This was a longitudinal observational prospective study. Method: 74 athletes, 60 men, and 14 women, aged between 16 and 45, divided into two groups: the Group-Lesion of ACL with 34 athletes (24.1 years) and the Group-Control with 40 athletes without ACL lesion (27.7 years old). All volunteers performed posturography, isokinetic dynamometry, and the Hop-Test. The ACL-Group was evaluated before and 12 months after the reconstruction and the control group was evaluated once. Results: The Postoperative ACL Group presented greater limb symmetry, 0.96 (± 0.12), than the preoperative ACL Group, 0.87 (± 0.17), p < 0.01 in the Hop-Test. In the posturography, the displacement area was smaller in the postoperative ACL Group, 19.85 (± 5.74), compared to the preoperative ACL Group, 24.20 (± 8.97), p < 0.01. In isokinetic dynamometry the torque peak was greater in the postoperative ACL Group, 0.91 (± 0.14), than in the preoperative ACL Group, 0.74 (± 0.15), p < 0.01. Conclusion: The functional outcomes increased in ACL reconstruction athletes after 12 months, but not at the same level as in the Control Group. The result indicates an incomplete functional recovery, adaptive changes in postural control after injury, reconstruction, and return to sport.

https://doi.org/10.1016/j.clinsp.2022.100092

Consensus on diagnosis and management of non-metastatic castration resistant prostate cancer in Brazil: focus on patient, selection, treatment efficacy, side effects and physician's perception according to patient comorbidities
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Maluf, Fernando

; Soares, Andrey

; Avanço, Guilherme

; Hada, Aline Lury

; Cardoso, Ana Paula Garcia

; Carneiro, Arie

; Herchenhorn, Daniel

; Jardim, Denis Leonardo Fontes

; Schutz, Fabio Augusto

; Kater, Fabio Roberto

; Pereira, Felipe Moraes Toledo

; Monteiro, Fernando Sabino Marques

; Morbeck, Igor Alexandre Protzner

; Reolon, João Francisco Navarro

; Trindade, Karine Martins da

; Andrade, Livia Maria Querino da Silvo

; Nogueira, Lucas Mendes

; Furoni, Renato

; Natel, Ricardo Azze

; Reis, Rodolfo Borges dos

; Fogace, Rodrigo Nogueira

; Souza, Vinicius Carrera

International braz j urol

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mar 2021, Volume 47 N. 2 Pages 359 - 373

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Non-metastatic castration resistant prostate cancer (M0 CRPC) has seen important developments in drugs and diagnostic tools in the last two years. New hormonal agents have demonstrated improvement in metastasis free survival in M0 CRPC patients and have been approved by regulatory agencies in Brazil. Additionally, newer and more sensitive imaging tools are able to detect metastasis earlier than before, which will impact the percentage of patients staged as M0 CRPC. Based on the available international guidelines, a group of Brazilian urology and medical oncology experts developed and completed a survey on the diagnosis and treatment of M0 CRPC in Brazil. These results are reviewed and summarized and associated recommendations are provided. Objective: To present survey results on management of M0 CRPC in Brazil. Design, setting, and participants: A panel of six Brazilian prostate cancer experts determined 64 questions concerning the main areas of interest: 1) staging tools, 2) treatments, 3) side effects of systemic treatment/s, and 4) osteoclast-targeted therapy. A larger panel of 28 Brazilian prostate cancer experts answered these questions in order to create country-specific recommendations discussed in this manuscript. Outcome measurements and statistical analysis: The panel voted publicly but anonymously on the predefined questions. These answers are the panelists' opinions, not a literature review or meta-analysis. Therapies not yet approved in Brazil were excluded from answer options. Each question had five to seven relevant answers including two non-answers. Results were tabulated in real time. Conclusions: The results and recommendations presented can be used by Brazilian physicians to support the management of M0 CRPC patients. Individual clinical decision making should be supported by available data, however, for Brazil, guidelines for diagnosis and management of M0 CRPC patients have not been developed. This document will serve as a point of reference when confronting this disease stage.

https://doi.org/10.1590/s1677-5538.ibju.2020.0249 789 downloads

Physical quality of eggs of four strains of poultry
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Almeida, Guilherme Resende de

; Mendonça, Michele de Oliveira

; Weitzel, Lidianne Carolina de Castro

; Bittencourt, Tatiana Marques

; Matos, Anderson Soares de

; Valentim, Jean Kaique

; Araújo, Michele Lopes de

; Oliveira, Adna Quesia Costa de

Acta Scientiarum. Animal Sciences

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2021, Volume 43 elocation e52738

Abstract: En | Text: En | PDF: En

ABSTRACT. The layer poultry is an important activity for food production with high biological value. Measuring egg quality has great relevance to ensure safety and quality products for consumers. Thus, the objective was to evaluate the egg physical quality of four laying hen’s strains. Were used 864 eggs from four laying hens’ lines (Hisex Brown®, Hy-Line Brown®, Isa Label®, and Lohmann Brown®). The experimental design was completely randomized composed of four treatments (strains) with nine replications with four eggs each. Egg weight, egg diameter, egg length, specific gravity, yolk, albumen and shell weight and percentage, Haugh units, and shell thickness were evaluated. There was a significant difference for all parameters evaluated. The Hisex Brown® strain showed the best results for egg diameter, egg length, specific weight, albumen height, Haugh units, yolk weight, albumen%, shell weight, shell%, and shell thickness, while the Hy-Line Brown® produced bigger and heavier eggs, and Isa Label® presented the highest yolk%. The Hisex Brown® strain showed the better physical quality of eggs when compared to the other studied lines, the strain being indicated when the objective is to produce eggs with better internal and external quality.

https://doi.org/10.4025/actascianimsci.v43i1.52738

Tansanal total mesorectal excision (TaTME): systematization and mediated results in 10 patients
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Neiva, Guilherme Inácio Bertoldo de Melo e Patriarca da Silva

; Soares, Fábio Alves

; Silva, Silvana Marques e

; Viana, Pedro Wilson Diniz

; Araújo Neto, Mário Nóbrega de

; Oliveira, Olane Marquez de

; Nascimento, Mauricio Cotrim

Journal of Coloproctology (Rio de Janeiro)

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mar 2020, Volume 40 N. 1 Pages 50 - 55

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Contexto A excisão total do mesorreto por via transanal é uma aborgadem crânio-caudal para a realização de ressecção minimamente invasiva do reto e tecidos perirretais em monobloco. É adequada para pacientes com câncer de reto médio e distal confinados ao envelope mesorretal. Aqui relatamos uma série de pacientes submetidos à excisão total do mesorreto por via transanal. Métodos Dez pacientes foram selecionados para serem submetidos à excisão total do mesorreto por via transanal utilizando a plataforma SILS-Port®. Todos os pacientes eram portadores de câncer retal de localização extraperitoneal. O acesso abdominal para mobilização do cólon proximal, em todos os casos, foi realizado por laparoscopia. Como regra, a retirada do espécime cirúrgico, em nove casos, ocorreu por via transanal. Resultados Durante um período de 41 meses, 10 pacientes foram submetidos à excisão total do mesorreto por via transanal com intenção curativa. A indicação primária para excisão total do mesorreto transanal foi o câncer de reto médio e distal, localmente invasor, mas confinado ao envelope mesorretal. A mediana de idade dos pacientes com câncer de reto no momento da cirurgia foi de 61 anos (média de 59,4 anos, faixa de 22‒78 anos), sendo 80% (8) do sexo feminino e 20% (2) do sexo masculino. A mediana do tempo cirúrgico foi de 305’ (média de 314’, intervalo de 260‒420’). A mediana do tempo de permanência pós-operatória foi de cinco dias (média de 7,3 dias, intervalo de 3‒23 dias). Não houve mortalidade pós-operatória. As complicações cirúrgicas incluíram íleo paralítico (n = 1), paresia vesical (n = 1) e estenose de ileostomia (n = 1). Todos os pacientes tiveram margens cirúrgicas negativas para neoplasia e mais de 12 linfonodos ressecados. Os tumores distavam de 1 a 9 cm da margem anal. Conclusão A excisão total do mesorreto transanal demonstrou-se um método viável para a ressecção oncológica de câncer de reto localmente avançado com intenção curativa.

Abstract Background Transanal total mesorectal excision is a surgical technique for minimally invasive resection of the rectum and perirectal tissues. It is indicated for patients with medial and distal rectum cancer confined to the mesorectal envelope. This study describes a series of patients undergoing transanal total mesorectal excision. Methods Ten patients were selected to undergo transanal total mesorectal excision using the SILS-Port® platform. All patients included here had middle or low rectal cancer. Abdominal access for proximal colon mobilization was performed by laparoscopy in all cases. As a rule, in 9 of the 10 cases, the surgical specimen was removed transanally. Results During a 41-month period, 10 patients underwent transanal total mesorectal excision based on curative intent. The first indication for transanal total mesorectum excision was medial and distal rectal cancer, locally invasive and confined to the mesortal envelope. The median age of patients with rectal cancer at the time of surgery was 61 years (mean 59.4 years, range 22–78 years), with 80% (8) female and 20% (2) male. The median surgical time was 305′ (mean 314′, range 260‒420′). The median postoperative length of stay was five days (average of 7.3 days, interval of 3–23 days). There was no postoperative mortality. Surgical complications included postoperative ileus (n = 1), bladder paresis (n = 1), and ileostomy stenosis (n = 1). All patients had negative surgical margins for neoplasia and more than 12 resected lymph nodes. The tumors were between 1 and 9 cm from the anal margin. Conclusion Total transanal mesorectal excision has been shown to be a viable method for oncologic resection of locally advanced rectal cancer with curative intent.

https://doi.org/10.1016/j.jcol.2019.09.004 695 downloads

Epidemiology of domestic cat behavioral problems in the city of Porto Alegre/Brazil: a survey of small animal veterinary practitioners
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Albuquerque, Nathalia Saraiva de

; Soares, Guilherme Marques

Ciência Rural

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2019, Volume 49 N. 10 elocation e20190147

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A popularidade do gato como animal de companhia vem crescendo, e junto com esse crescente número de gatos, crescem também as queixas de problemas comportamentais dessa espécie. Os problemas de comportamento comprometem o bem-estar dos animais e a qualidade de vida das pessoas que com eles convivem, sendo uma das principais causas de abandono e eutanásia de gatos em alguns países. O objetivo do presente estudo foi avaliar a prevalência dos problemas comportamentais em gatos atendidos pelos médicos veterinários no município de Porto Alegre, RS. Essa avaliação foi feita através de um questionário aplicado em consultórios, clínicas e hospitais veterinários de pequenos animais, para serem respondidos pelos médicos veterinários responsáveis pelo atendimento clínico. Dos 100 questionários respondidos pelos médicos veterinários, 92,0% afirmam que são consultados sobre problemas de comportamento e 72,0% responderam que o cão era a espécie mais consultada. No que se refere aos problemas comportamentais específicos dos gatos, a arranhadura foi a queixa comportamental mais comum citada pelos médicos veterinários (40,0%), seguida de agressividade (39,0%) e eliminação inapropriada com urina (38,0%). A agressividade (73,8%) e a arranhadura (56,9%) foram citadas como as mais frequentes razões que podem levar ao abandono ou eutanásia dos gatos. Os resultados dessa pesquisa destacam a importância de haver maior conhecimento sobre o comportamento normal do gato, e o papel fundamental do médico veterinário clinico na prevenção de problemas comportamentais e no abandono desses animais.

ABSTRACT: The popularity of cats as a companion animal has been growing. Additionally, there is also an increase in the number of complaints regarding behavioral problems associated with the species. Behavioral problems interfere with the animal welfare and quality of people’s lives that are living with them, and are one of the main reasons for abandonment and euthanasia in some countries. This study aimed to investigate the prevalence of behavioral problems among cats with the help of veterinary practitioners in the city of Porto Alegre/Brazil. This evaluation was performed through a questionnaire in veterinary clinics and hospitals of small animals, which was answered by veterinarians responsible for clinical care. The study showed that most veterinarians (92.0%) have been sought to assist with behavioral problems and that dogs were the most consulted species (72.0%). Regarding cats, scratching was the most common owners’ complaints (40.0%), followed by aggressiveness (39.0%), and inappropriate elimination of urine (38.0%). Aggression (73.8%) and scratching (56.9%) were the most frequent reasons that may lead to the abandonment or euthanasia of cats. Results of this research highlighted the importance of having a better understanding about the normal behavior of cats, and the fundamental role of the veterinarian in preventing behavioral problems and abandonment of these animals.

https://doi.org/10.1590/0103-8478cr20190147 1369 downloads

Tratamento de endoleak tipo 1A mediante embolização com molas: relato de caso
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Belczak, Sergio Quilici

; Pedroso, Guilherme Delicato

; Ogawa, Lara Cote

; Campos, Paula Thume

; Padula, Andre Lopes

; Machado, Glenna Paulain

; Santos, Matheus Zago Soares dos

; Abrão, Beatriz Marques

Jornal Vascular Brasileiro

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2019, Volume 18 elocation e20180130

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo No endoleak tipo 1A, a endoprótese não sela completamente o colo do aneurisma proximal, e o fluxo arterial está presente entre a parede do colo aórtico e o material do implante. Este é um relato de um caso no qual foi utilizada embolização com molas, associado a uma revisão de literatura (PubMed, LILACS e SciELO). Foram pesquisados artigos publicados nos últimos 5 anos com os descritores “endoleak 1A”, “coil embolization” e “treatment”, combinados de formas aleatórias, sendo encontrados 25 artigos. O tipo 1A ocorre em 1,1% dos pacientes após 30 dias do implante. O tratamento consiste em aumentar a vedação do implante proximal, principalmente com o uso de stents e balões para alargar a zona de aterragem ou aumentar a força radial do implante. Alguns trabalhos sugerem técnicas de embolização com cianoacrilato, cola de fibrina e uso de Onyx, mostrando taxas de sucesso superiores a 97%. Contudo, a correção de endoleaks tipo 1A mediante embolização com molas é pouco descrita.

Abstract In a type 1A endoleak, the endograft is unable to fully seal the proximal aneurysm neck and blood flow leaks between the wall of the aortic neck and the graft material. This article reports a case in which coil embolization was used and presents a literature review (PubMed, LILACS, and SciELO). Searches were run for articles published in the past 5 years using the descriptors “endoleak 1A”, “coil embolization,” and “treatment”. Type 1A endoleak occurs in 1.1% of patients within 30 days of graft placement. Treatment of an endoleak is obligatory and usually consists of sealing the proximal graft neck using stents and balloons to expand the landing zone or to increase the radial force of the graft. Some studies have suggested using embolization techniques with cyanoacrylate, fibrin glue, and Onyx, demonstrating success rates that exceed 97%. However, correction of type 1A endoleak using coil embolization has seldom been described.

https://doi.org/10.1590/1677-5449.180130 2588 downloads

Neurofibromatosis: part 2 – clinical management
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Batista, Pollyanna Barros

; Bertollo, Eny Maria Goloni

; Costa, Danielle de Souza

; Eliam, Lucas

; Cunha, Karin Soares Gonçalves

; Cunha-Melo, José Renan

; Darrigo Junior, Luiz Guilherme

; Geller, Mauro

; Gianordoli-Nascimento, Ingrid Faria

; Madeira, Luciana Gonçalves

; Mendes, Hérika Martins

; Miranda, Débora Marques de

; Mata-Machado, Nikolas Andre

; Morato, Eric Grossi

; Pavarino, Érika Cristina

; Pereira, Luciana Baptista

; Rezende, Nilton Alves de

; Rodrigues, Luíza de Oliveira

; Sette, Jorge Bezerra Cavalcanti

; Silva, Carla Menezes da

; Souza, Juliana Ferreira de

; Souza, Márcio Leandro Ribeiro de

; Martins, Aline Stangherlin

; Valadares, Eugênia Ribeiro

; Vidigal, Paula Vieira Teixeira

; Waisberg, Vanessa

; Waisberg, Yehuda

; Rodrigues, Luiz Oswaldo Carneiro

Arquivos de Neuro-Psiquiatria

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jun 2015, Volume 73 N. 6 Pages 531 - 543

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A primeira parte desta diretriz abordou o diagnóstico diferencial das neurofibromatoses (NF): neurofibromatose do tipo 1 (NF1), neurofibromatose do tipo 2 (NF2) e schwannomatose (SCH). As NF compartilham algumas características, como a origem neural dos tumores e sinais cutâneos, e afetam cerca de 80 mil brasileiros. O aumento do conhecimento científico sobre as NF tem permitido melhor manejo clínico e redução da morbidade das complicações, resultando em melhor qualidade de vida para os pacientes com NF. A maioria dos médicos é capaz de realizar o diagnóstico das NF, mas a variedade de manifestações clínicas e a dificuldade de se prever o surgimento e a gravidade de complicações, torna o manejo da NF um desafio para o clínico e envolve diferentes especialistas para o tratamento adequado e aconselhamento genético, especialmente a NF2 e a SCH. O presente texto sugere algumas orientações para o acompanhamento dos portadores de NF, com ênfase na NF1.

Part 1 of this guideline addressed the differential diagnosis of the neurofibromatoses (NF): neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2) and schwannomatosis (SCH). NF shares some features such as the genetic origin of the neural tumors and cutaneous manifestations, and affects nearly 80 thousand Brazilians. Increasing scientific knowledge on NF has allowed better clinical management and reduced rate of complications and morbidity, resulting in higher quality of life for NF patients. Most medical doctors are able to perform NF diagnosis, but the wide range of clinical manifestations and the inability to predict the onset or severity of new features, consequences, or complications make NF management a real clinical challenge, requiring the support of different specialists for proper treatment and genetic counseling, especially in NF2 and SCH. The present text suggests guidelines for the clinical management of NF, with emphasis on NF1.

https://doi.org/10.1590/0004-282X20150042 13090 downloads

Bleomycin-induced flagellate dermatitis
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Mota, Guilherme Devidé

; Penna, Adriana Marques Damasco

; Soares, Regina Cláudia

; Baiocchi, Otávio Carvalho Guimarães

Revista Brasileira de Hematologia e Hemoterapia

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aug 2014, Volume 36 N. 4 Pages 297 - 299

Abstract: En | Text: En | PDF: En

A 29-year-old woman with stage IVB Hodgkin's lymphoma was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine. Two weeks after the first cycle was completed, she developed pruritic, linear erythematous lesions in a flagellate-like pattern on the trunk, neck and arms. After oral prednisone therapy and cessation of bleomycin, the lesions started to recede.

https://doi.org/10.1016/j.bjhh.2014.03.001 1182 downloads Cited 1 time in SciELO

10.

Neurofibromatoses: part 1 ? diagnosis and differential diagnosis
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Rodrigues, Luiz Oswaldo Carneiro

; Batista, Pollyanna Barros

; Goloni-Bertollo, Eny Maria

; Souza-Costa, Danielle de

; Eliam, Lucas

; Eliam, Miguel

; Cunha, Karin Soares Gonçalves

; Darrigo Junior, Luiz Guilherme

; Ferraz Filho, José Roberto Lopes

; Geller, Mauro

; Gianordoli-Nascimento, Ingrid F.

; Madeira, Luciana Gonçalves

; Malloy-Diniz, Leandro Fernandes

; Mendes, Hérika Martins

; Miranda, Débora Marques de

; Pavarino, Erika Cristina

; Baptista-Pereira, Luciana

; Rezende, Nilton A.

; Rodrigues, Luíza de Oliveira

; Silva, Carla Menezes da

; Souza, Juliana Ferreira de

; Souza, Márcio Leandro Ribeiro de

; Stangherlin, Aline

; Valadares, Eugênia Ribeiro

; Vidigal, Paula Vieira Teixeira

Arquivos de Neuro-Psiquiatria

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mar 2014, Volume 72 N. 3 Pages 241 - 250

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Neurofibromatoses (NF) constituem um grupo de doenças genéticas com predisposição ao crescimento de múltiplos tumores: tipo 1 (NF1), tipo 2 (NF2) e schwannomatose (SCH). Estas doenças têm em comum a origem neural dos tumores e os sinais cutâneos. Afetam cerca de 80 mil brasileiros. O maior conhecimento científico sobre as NF tem permitido melhor manejo clínico, redução da morbidade das complicações e melhor qualidade de vida. Na maioria dos casos, os especialistas em neurologia, dermatologia, genética clínica, oncologia e medicina interna estão capacitados a realizar o diagnóstico diferencial e identificar suas principais complicações. Devido à sua variabilidade fenotípica, curso progressivo, multiplicidade de órgãos acometidos e evolução imprevisível, as NF frequentemente necessitam de especialistas em NF para o acompanhamento. A Parte 1 deste texto oferece orientações para o diagnóstico de cada tipo de NF e discute os diagnósticos diferenciais com outras doenças. A Parte 2 oferecerá orientações em relação ao manejo clínico das NF.

Neurofibromatoses (NF) are a group of genetic multiple tumor growing predisposition diseases: neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2) and schwannomatosis (SCH), which have in common the neural origin of tumors and cutaneous signs. They affect nearly 80 thousand of Brazilians. In recent years, the increased scientific knowledge on NF has allowed better clinical management and reduced complication morbidity, resulting in higher quality of life for NF patients. In most cases, neurology, psychiatry, dermatology, clinical geneticists, oncology and internal medicine specialists are able to make the differential diagnosis between NF and other diseases and to identify major NF complications. Nevertheless, due to its great variability in phenotype expression, progressive course, multiple organs involvement and unpredictable natural evolution, NF often requires the support of neurofibromatoses specialists for proper treatment and genetic counseling. This Part 1 offers step-by-step guidelines for NF differential diagnosis. Part 2 will present the NF clinical management.

https://doi.org/10.1590/0004-282X20130241 22696 downloads

11.

Desenvolvimento e caracterização de nanopartículas lipídicas destinadas à aplicação tópica de dapsona
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Santos, Guilherme Soares dos

; Pereira, Gabriela Garrastazu

; Bender, Eduardo André

; Colomé, Letícia Marques

; Guterres, Sílvia Stanisçuaski

; Carvalho, Daniel Canema Manhães de

; Weissmüller, Gilberto

Química Nova

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2012, Volume 35 N. 7 Pages 1388 - 1394

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%).

6232 downloads

12.

Epidemiologia de problemas comportamentais em cães no Brasil: inquérito entre médicos veterinários de pequenos animais
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Soares, Guilherme Marques

; Souza-Dantas, Letícia Mattos de

; D’Almeida, José Mário

; Paixão, Rita Leal

Ciência Rural

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apr 2010, Volume 40 N. 4 Pages 873 - 879

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Problemas de comportamento afetam diretamente a qualidade de vida dos animais e das pessoas que com eles convivem. Em alguns países, os problemas de comportamento são as principais causas de abandono e eutanásia de animais de companhia. O presente estudo objetivou avaliar a prevalência dos problemas de comportamento dos cães na rotina clínica dos médicos veterinários brasileiros por meio do envio de questionários às faculdades de Medicina Veterinária do Brasil, para serem respondidos pelos profissionais responsáveis pelo atendimento clínico a cães e gatos. No total de 101 questionários respondidos, 91,1% dos participantes afirmaram ser consultados sobre problemas de comportamento e 82,2% afirmaram que a maior frequência das queixas comportamentais foi relacionada à espécie canina. Os respondentes, em sua maioria (56,7%), relataram que tentaram resolver sozinhos alguns casos ou encaminharam o caso para um veterinário especializado. Dentre os respondentes, 89,1% afirmaram não realizar eutanásia em razão de problemas de comportamento. O problema de comportamento citado como o mais frequente foi a destrutividade e, em seguida, as agressões. O tratamento mais recomendado, tanto para agressões quanto para eliminações inapropriadas de urina, foi a terapia comportamental.

Behavior issues directly affect animal and human welfare. In some countries, behavior problems are the main reasons for abandonment and euthanasia of companion animals. The present study aimed to investigate the prevalence of behavior problems among dogs seem by Brazilian veterinarians, by sending questionnaires to be responded by veterinarians at university referral animal hospitals in Brazil. Among 101 responses, 91.1% of participants affirmed to be consulted about behavior issues, and 82.2% said that they mostly concern dogs. Most veterinarians (56.7%) try to solve some behavior cases by themselves and refer others to a specialized colleague. Most affirmed to do not perform euthanasia due to behavior issues (89.1%). The most common complaint among owners was destructive behavior, followed by aggressions. The most recommended treatment for aggressive behavior and inappropriate elimination of urine was behavior therapy.

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13.

Estudo exploratório da síndrome de ansiedade de separação em cães de apartamento
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Soares, Guilherme Marques

; Pereira, João Telhado

; Paixão, Rita Leal

Ciência Rural

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mar 2010, Volume 40 N. 3 Pages 548 - 553

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A síndrome de ansiedade de separação em animais é um distúrbio de comportamento caracterizado, em cães, por comportamentos indesejados manifestados por esses animais quando afastados de suas figuras de apego. Este trabalho buscou caracterizar o problema na população de cães residentes em apartamento de um bairro no Município de Niterói, Rio de Janeiro (RJ), por meio de uma pesquisa de campo por meio de dois questionários, um para identificação da síndrome de ansiedade de separação (QI-SASA) e outro questionário de apoio. Nessa população, 55,9% dos cães apresentaram seus sinais característicos, sendo as manifestações mais frequentes as vocalizações excessivas (53,8%), os comportamentos destrutivos (46,1%) e os comportamentos depressivos (34,6%). Os resultados também sugerem um impacto negativo na qualidade de vida dos proprietários dos cães que desenvolvem a SASA.

Separation anxiety syndrome in animals is a behavioral disorder characterized by undesirable wanted behaviour showed by dogs when they are away from their attachment figures. In this study, with the goal of understanding the syndrome in indoor dogs from a suburb of the city of Niterói, Rio de Janeiro (RJ), two questionnaires were used: a questionnaire to identify separation anxiety syndrome in animals (QI-SASA) and a questionnaire of support. In the surveyed population, 55.9% of the dogs presented clinical signs of SASA, being the most frequent excessive vocalizations (53.8%), destructive behaviours (46.1%), and depressive behaviour (34.6%). The results also suggest a negative impact on the life quality of the owners and dogs.

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14.

Construção e validação de um questionário para identificação da Síndrome de Ansiedade de Separação em cães domésticos
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Soares, Guilherme Marques

; Telhado, João

; Paixão, Rita Leal

Ciência Rural

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- Sobre o periódico
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jun 2009, Volume 39 N. 3 Pages 778 - 784

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Em cães, a Síndrome de Ansiedade de Separação em Animais (SASA) pode ser definida como um conjunto de comportamentos indesejáveis exibidos por esses animais quando afastados da figura de apego. A partir da necessidade de um levantamento epidemiológico sobre esse problema, foi desenvolvido um questionário para identificação da SASA em cães (QI-SASA) com base em dados da literatura e validado por meio de dois procedimentos. O primeiro foi a comparação entre pareceres de médicos veterinários brasileiros que atuam na área de etologia clínica a respeito de 40 QI-SASA respondidos por proprietários de cães. O segundo foi a comparação dos resultados da avaliação de 40 QI-SASA, a partir dos critérios estabelecidos neste trabalho, com o resultado de entrevistas para o diagnóstico da SASA. O QI-SASA mostrou-se completo, coerente e confiável com a finalidade de um levantamento epidemiológico do problema.

The Separation Anxiety Syndrome in Animals (SASA) and being more specific, in dogs, can be defined as a group of undesirable behaviors displayed by dogs when they are away from the attachment subject. The questionnaire was developed due to the need to identify this disorder and conduct an epidemiologic survey on SASA in dogs (QI-SASA). This instrument was developed based on reference data and was validated through two procedures. The first one was the comparison among evaluations of Brazilian ethologists on the appliance of 40 QI-SASA to dogs' owners. The second was the comparison between the previous evaluations, according to the criteria established in this research, with the results of the interviews to diagnose SASA. The QI-SASA seems to be a complete, safe and trustworthy tool to carry out epidemiologic surveys on SASA.

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