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Research to identify plant bioactive compounds led to the evolution of extraction methods. This study optimized ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) to extract the flavonoids of Croton grewioides Baill. species contributing to characterize the polar extract profile and understand the antioxidant potential of these plant constituents. The use of experimental design and statistical treatments enabled the determination of the ideal conditions for each technique. The extracts of five accessions of C. grewioides were obtained under the optimized extraction conditions and were analyzed using ultra high-resolution mass spectrometry (FT-Orbitrap MS) operating at negative ionization mode for flavonoids detection. The accurate experimental mass obtained to the main compounds was used to attribute the molecular formula. Chemical structures of the main compounds detected were proposed using structure data bases. Chemometric analysis were performed with two FT-Orbitrap MS spectra samples using the identified metabolites and, the antioxidant activity data, showing that for this species the MAE was most effective in extracting the antioxidant compounds. It was possible to propose the structures for forty compounds in the C. grewioides extracts, demonstrating the excellent performance of the FT-Orbitrap MS in providing information on the chemical profile of polar compounds in plant extracts.

https://doi.org/10.21577/0103-5053.20230004

Dark chocolate (70% cocoa) reduces craving in smokers with severe cardiovascular comorbidities without interference in anthropometric measures
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Gomes, Arthur da Silva

; Melo, Marcela Melquíades

; Silva, Thayzis de Paula

; Galil, Arise G. de Siqueira

; Percegoni, Nathércia

; Luquetti, Sheila C. P. Dutra

; Bastos Netto, André

; Fonseca, Vilma Aparecida da Silva

; Aguiar, Aline Silva de

Jornal Brasileiro de Psiquiatria

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2023, Volume 72 N. 4 Pages 221 - 227

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: Analyze craving in smokers with cardiovascular comorbidities submitted to a nutritional approach. Methods: Two groups were randomized and submitted to clinical intervention (n = 32): Group 1 (G1, n = 15): ingested 40 g of chocolate containing 70% cocoa/day and behavioral intervention for smoking cessation for one month; Group 2 (G2, n = 17): control group, only behavioral intervention. Questionnaire of Smoking Urges-Brief (QSU-Brief) - Brazil version measured total craving and its factors. Anthropometric measurements verified the nutritional interference of the procedure and the serum assessment verified the interference of inflammatory processes related to smoking. The study was registered on the Brazilian Registry of Clinical Trials (ReBEC): RBR-83jr3. Results: After one month, compared to the initial evaluation, the G1 reduced the craving evaluated by the QSU-Brief and its Factors 1 and 2. Total QSU-Brief: 44.27 ± 15.82 x 27.00 ± 18.03 (p = 0.008); Factor 1: 21.90 ± 7.70 x 12.90 ± 8.87 (p = 0.006); Factor 2: 11.90 ± 6.30 x 7.00 ± 6.63 (0.007). G2 showed a reduction in total QSU-Brief and Factor 1, but not in Factor 2. QSU-Brief total 28.17 ± 17.24 x 19.52 ± 9.50 (p = 0.049); Factor 1: 14.47 ± 8.74 x 9.23 ± 6.11 (p = 0.046). Serum levels of cortisol, leptin, serotonin, C-Reactive Protein (CRP) and insulin did not show differences (p > 0.05). No anthropometric differences were found. Conclusion: The results demonstrate that daily consumption of chocolate for one month (70%) reduced craving in smokers at the beginning of treatment. Chocolate potentiated the well-known effect of behavioral counseling on Factor 1 (pleasurable drug effects) and also interfered with factor 2 (unpleasant withdrawal effects).

RESUMO Objetivo: Analisar o craving em fumantes com comorbidades cardiovasculares submetidos a uma abordagem nutricional. Métodos: Intervenção clínica (n = 32) com dois grupos randomizados: Grupo 1 (G1, n = 15): recebendo 40 g de chocolate contendo 70% de cacau/dia e intervenção comportamental para cessação do tabagismo por um mês; Grupo 2 (G2, n = 17): grupo controle, recebendo apenas intervenção comportamental pelo mesmo período. O Questionnaire of Smoking Urges-Brief (QSU-Brief) – versão Brasil foi utilizado para avaliar o craving. As medidas antropométricas verificaram a interferência nutricional do procedimento e a avaliação sérica, a interferência de processos inflamatórios relacionados ao tabagismo. O estudo foi registrado no Registro Brasileiro de Ensaios Clínicos (ReBEC), RBR-83jr3. Resultados: Um mês depois, comparado à avaliação inicial, o G1 reduziu o craving total e seus fatores (1 e 2). QSU-Brief total: 44,27 ± 15,82 x 27,00 ± 18,03 (p = 0,008); Fator 1: 21,90 ± 7,70 x 12,90 ± 8,87 (p = 0,006); Fator 2: 11,90 ± 6,30 x 7,00 ± 6,63 (0,007). G2: redução no QSU-Brief total e Fator 1, mas não no Fator 2. QSU-Brief total 28,17 ± 17,24 x 19,52 ± 9,50 (p = 0,049); Fator 1: 14,47 ± 8,74 x 9,23 ± 6,11 (p = 0,046). Níveis séricos de cortisol, leptina, serotonina, proteína C-reativa (PCR) e insulina não apresentaram diferenças (p > 0,05). Não foram encontradas diferenças antropométricas significativas. Conclusão: Os resultados demonstram que o consumo diário de chocolate por um mês (70%) reduziu o craving em fumantes no início do tratamento. O chocolate potencializou o conhecido efeito do aconselhamento comportamental sobre o Fator 1 (efeitos prazerosos da droga) e também interferiu no fator 2 (efeitos desagradáveis da abstinência).

https://doi.org/10.1590/0047-2085000000431

CÂNCER DE MAMA E ANÁLISE DOS FATORES RELACIONADOS AOS MÉTODOS DE DETECÇÃO E ESTADIAMENTO DA DOENÇA
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Dourado, Cynthia Angelica Ramos de Oliveira

; Santos, Cícera Maria Fernandes dos

; Santana, Vilma Maria de

; Gomes, Thaís Neves

; Cavalcante, Laysa Thayane Silva

; Lima, Morgana Cristina Leôncio de

Cogitare Enfermagem

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2022, Volume 27 elocation e81039

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: descrever o perfil das mulheres acometidas pelo câncer de mama e avaliar os aspectos relacionados aos métodos de detecção e estadiamento da doença e suas associações. Método estudo transversal, com 350 mulheres diagnosticadas com câncer de mama, atendidas em centros especializados de Pernambuco - Brasil, entre junho de 2018 e janeiro de 2019. Para a análise, foram realizadas associações e comparações com o teste Qui-quadrado. Resultados 40,3% da amostra tinha <50 anos, o autoexame foi o método prevalente de detecção (74,9%) em todas as faixas etárias, com associação significativa para estádios mais avançados da doença, >70% da amostra. Conclusão: a detecção pelo autoexame foi expressiva e estava relacionada com estádios mais avançados do câncer de mama, principalmente em faixas etárias mais jovens. Diante dos resultados, os atores envolvidos com a saúde da mulher poderão desenvolver novas estratégias para intensificar o rastreamento populacional.

ABSTRACT Objective: to describe the profile of women affected by breast cancer and to evaluate the aspects related to the disease detection and staging methods and their associations. Method: a cross-sectional study conducted with 350 women diagnosed with breast cancer treated in specialized centers from Pernambuco - Brazil, between June 2018 and January 2019. For the analysis, associations and comparisons were made with the Chi-square test. Results: 40.3% of the sample was <50 years old, and self-examination was the prevalent detection method (74.9%) in all age roups, with a significant association for more advanced stages of the disease, >70% of the sample. Conclusion: detection by self-examination was significant and was related to more advanced stages of breast cancer, especially in younger age groups. Given the results, the actors involved in women’s health may develop new strategies to intensify population screening.

RESUMEN Objetivo: describir el perfil de las mujeres afectadas por cáncer de mama y evaluar aspectos relacionados con los métodos de detección y estadificación de la enfermedad y sus asociaciones. Método: estudio transversal, con 350 mujeres diagnosticadas con cáncer de mama, atendidas en centros especializados de Pernambuco, Brasil, entre junio de 2018 y enero de 2019. Para el análisis, se realizaron asociaciones y comparaciones con la prueba de Chi-cuadrado. Resultados: el 40,3% de la muestra tenía <50 años, el método de detección prevalente fue el autoexamen (74,9%) en todas las franjas etarias y había una asociación significativa con los estadios más avanzados de la enfermedad, >70% de la muestra. Conclusión: la detección mediante el autoexamen fue significativa y se relacionó con estadios más avanzados de cáncer de mama, especialmente en las franjas etarias más jóvenes. Estos resultados, les permitirán a los actores involucrados en la salud de la mujer desarrollar nuevas estrategias para intensificar la detección poblacional.

https://doi.org/10.5380/ce.v27i0.81039

Recovering records on cancer of the larynx from anonymous health information databases
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Fernandes, Fernando Timoteo

; Silva, Diego Rodrigues Mendonça e

; Campos, Felipe

; Santana, Vilma Sousa

; Cuani, Lucas

; Curado, Maria Paula

; Salvi, Leonardo

; Algranti, Eduardo

Revista Brasileira de Epidemiologia

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2021, Volume 24 elocation e210011

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Desenvolver um algoritmo de vinculação de registros para parear registros de óbito por câncer de laringe (CID-10 C32X), recuperados do Sistema de Informação de Mortalidade (SIM) e do Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH-SUS) do Brasil. Métodos: Foram filtrados registros de óbitos contendo códigos CID-10 C32X do SIM e do SIH-SUS, de indivíduos de mais de 30 anos, entre 2002 e 2012, no Estado de São Paulo. As bases de dados foram vinculadas por meio de um identificador único e de variáveis sociodemográficas comuns a ambos os sistemas. O desempenho da vinculação de dados foi aferido aplicando-se o mesmo procedimento em bancos de dados nominais. Os pares verdadeiros apresentavam os mesmos valores nas variáveis de identificação. Resultados: Ao todo, 14.311 registros elegíveis de óbito foram encontrados. A maioria dos registros, 10.674 (74.6%), era exclusiva do SIM. Apenas 1.853 (12.9%) óbitos foram registrados em ambos os sistemas, representando pares verdadeiros. Um total de 1.784 (12.5%) casos de câncer de laringe presentes no SIH-SUS constavam com diferentes causas de óbito no SIM. Houve falha na vinculação em 167 (9.4%) registros, devido a inconsistências na chave de identificação. Conclusão: Constatou-se que a vinculação de dados anônimos de registros hospitalares e registros de óbito é viável e pode auxiliar na melhoria de estatísticas de câncer.

ABSTRACT: Objective: To develop a linkage algorithm to match anonymous death records of cancer of the larynx (ICD-10 C32X), retrieved from the Mortality Information System (SIM) and the Hospital Information System of the Brazilian Unified National Health System (SIH-SUS) in Brazil. Methodology: Death records containing ICD-10 C32X codes were retrieved from SIM and SIH-SUS, limited to individuals aged 30 years and over, between 2002 and 2012, in the state of São Paulo. The databases were linked using a unique key identifier developed with sociodemographic data shared by both systems. Linkage performance was ascertained by applying the same procedure to similar non-anonymous databases. True pairs were those having the same identification variables. Results: A total of 14,311 eligible death records were found. Most records, 10,674 (74.6%), were exclusive to SIM. Only 1,853 (12.9%) deaths were registered in both systems, representing true pairs. A total of 1,784 (12.5%) cases of laryngeal cancer in the SIH-SUS database were tracked in SIM with different causes of death. The linkage failed to match 167 (9.4%) records due to inconsistencies in the key identifier. Conclusion: The authors found that linking anonymous data from mortality and hospital records is a feasible measure to track missing records and may improve cancer statistics.

https://doi.org/10.1590/1980-549720210011

Recovering records on cancer of the larynx from anonymous health information databases
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Fernandes, Fernando Timoteo

; Silva, Diego Rodrigues Mendonça e

; Campos, Felipe

; Santana, Vilma Sousa

; Cuani, Lucas

; Curado, Maria Paula

; Salvi, Leonardo

; Algranti, Eduardo

Revista Brasileira de Epidemiologia

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2021, Volume 24 elocation e210011

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720210011 567 downloads

Relationship between food consumption of pregnant women and birth weight of newborns
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Rodrigues, Beatriz

; Azeredo, Vilma

; Silva, Alexandra

Revista chilena de nutrición

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feb 2020, Volume 47 N. 1 Pages 80 - 88

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT The aim of this study was to investigate the relationship between food consumption of 99 pregnant women aged 16-44 years who gave birth at a maternity hospital in Rio de Janeiro and newborn birth weight. Maternal consumption of unprocessed or minimally processed and ultra-processed foods was evaluated through the Food Consumption Markers Form. For ultra-processed foods, most pregnant women regularly consumed sweets (73.7%), soft drinks (71.7%), sausages (65.7%), salted crackers (63.6%) and fried foods (55.6%). Among unprocessed or minimally processed foods, most pregnant women consumed beans (85.9%) and milk or yogurt (60.6%), while less than half consumed fruits (44.4%), raw vegetables (28.3%) and cooked vegetables (27.3%) regularly. Among newborns, 13.5% presented low birth weight. There was a significant relationship between consumption of sausages (p= 0.02) and sweets (p= 0.04) by pregnant women and low birth weight of newborns. Maternal consumption of sausages increased the odds of newborn low birth weight (OR 1.46, 95% CI 1.02-2.10).

RESUMEN El objetivo fue investigar la relación entre el consumo de alimentos de 99 gestantes de 16 a 44 años, atendidas en una maternidad de Río de Janeiro, y el peso al nacer de los recién nacidos. El consumo materno de alimentos no procesados o mínimamente procesados y ultraprocesados se evaluó a través del Formulario de Marcadores de Consumo de Alimentos. Se observó que entre los recién nacidos, 13,5% tenían bajo peso al nacer. La evaluación del consumo de alimentos maternos mostró que, entre los alimentos ultraprocesados, la mayoría de las gestantes consumieron regularmente dulces (73,7%), gaseosas (71,7%), embutidos (65,7%), galletas saladas (63,6%) y frituras (55,6%). Entre los alimentos no procesados o mínimamente procesados, la mayoría de las gestantes consumieron frijoles (85,9%) y leche o yogur (60,6%), mientras que menos de la mitad utilizaba frutas (44,4%), verduras crudas (28,3%) y verduras cocidas (27,3%) regularmente. Se observó una relación significativa entre el consumo de embutidos (p= 0,02) y dulces (p= 0,04) en gestantes con el bajo peso al nacer. El consumo materno de embutidos aumenta la probabilidad de que los recién nacidos presenten bajo peso al nacer, a medida que aumenta su consumo (OR 1,46, IC 95% 1,02-2,10).

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Care handover to chronic conditions to regionalized planning
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Pena, Kamila da Silva

; Rollo, Rosane Machado

; Reuter, Camila Luana Oliveira

; Santos, Vilma Constancia Fioravante dos

; Riquinho, Deise Lisboa

; Ramos, Adriana Roese

Revista Gaúcha de Enfermagem

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2020, Volume 41 N. spe elocation e20190168

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective: To analyze the possibilities of the transition from care to the problem of chronic illness due to the need of regionalized municipal planning. Method: An exploratory qualitative study was carried out in one of the Health Regions of Rio Grande do Sul, together with the Primary Health Care Coordinators. Results: The final thematic categories that emerged from the results were: “The relationship between municipalities of the Health Region and health planning”, Organizational flow of care of users with chronic diseases”, and “Managing care in the health system: meeting the demands of chronically sick users”. Conclusions: The scenario under study demonstrates the persistence of barriers that affect health care for NCDs, such as the scarcity of investments, lack of planning and disarticulation of communication among municipalities. These conditions reflect on the path of the user among the health services, weakening the transition process of care.

Resumen Objetivo: Analizar las posibilidades de la transición del cuidado ante la problemática del enfermo crónico ante la necesidad de la planificación municipal regionalizada. Método: Estudio exploratorio de abordaje cualitativo, realizado en una de las Regiones en Salud de Rio Grande do Sul junto a los Coordinadores de la Atención Primaria en Salud. Resultados: Las categorías temáticas finales que surgieron de los resultados fueron: “La relación entre los municipios de la Región en Salud y planificación en salud”, “Flujo Organizacional de atención al enfermo crónico” y “La gestión del cuidado en la red de atención: el movimiento de atender la demanda de los enfermos crónica”. Conclusiones: El escenario en estudio demuestra la persistencia de trabas que afectan la atención en salud a las CCNT como la escasez de inversiones, insuficiencia en la planificación y desarticulación en la comunicación entre los municipios.

Resumo Objetivo: Analisar as possibilidades da transição do cuidado diante da problemática do adoecimento crônico face à necessidade do planejamento municipal regionalizado. Métodos: Estudo exploratório de abordagem qualitativa, realizado entre o segundo semestre de 2014 e o primeiro semestre de 2015, em uma Região em Saúde do Rio Grande do Sul junto aos Coordenadores da Atenção Primária em Saúde. A análise dos dados se deu por categorização temática. Resultados: As categorias temáticas identificadas foram: “A relação entre os municípios da Região em Saúde e o planejamento em saúde”, “Fluxo Organizacional de atendimento ao adoecido crônico” e “A gestão do cuidado na rede de atenção: o movimento de atender a demanda dos adoecidos crônicos”. Conclusões: Demonstra-se a persistência de entraves que afetam a atenção em saúde às Condições Crônicas Não Transmissíveis e se refletem na trajetória do usuário entre os serviços de saúde, fragilizando o processo da transição do cuidado.

https://doi.org/10.1590/1983-1447.2020.20190168 60 downloads

Care handover to chronic conditions to regionalized planning
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Pena, Kamila da Silva

; Rollo, Rosane Machado

; Reuter, Camila Luana Oliveira

; Santos, Vilma Constancia Fioravante dos

; Riquinho, Deise Lisboa

; Ramos, Adriana Roese

Revista Gaúcha de Enfermagem

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2020, Volume 41 N. spe elocation e20190168

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/1983-1447.2020.20190168 1256 downloads

Preconditioning with L-Ala-Gln reduces the expression of inflammatory markers (TNF-α, NF-κB, IL-6 and HO-1) in an injury animal model of cerebrovascular ischemia in Meriones unguiculatus (gerbils)
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Oliveira, Leidelamar Rosário Alves de

; Albuquerque, Andréa de Oliveira

; Silva, Cícero Igor Simões Moura

; Silva, Jussara Mathiele

; Casadevall, Meyssa Quezado de Figueiredo Cavalcante

; Azevedo, Orleancio Gomes Ripardo de

; Albuquerque, Vilma Leite de Souza Pires

; Vasconcelos, Paulo Roberto Leitão de

Acta Cirúrgica Brasileira

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2020, Volume 35 N. 6 elocation e202000601

Abstract: En | Text: En | PDF: En

Abstract Purpose To evaluate the neuroprotective effect of L-alanyl-glutamine in a gerbil model of brain ischemia-reperfusion injury based on immunohistochemical quantification of pro-inflammatory and cell activation biomarkers (TNF-α, NF-κB, IL-6 and HO-1). Methods Male gerbils weighing 100-180 g were pretreated with either 0.75 g/kg L-Ala-Gln (n=18) or 2.0 mL saline (n=18) administered i.v. 30 minutes before the bilateral ligation of the common carotid artery during 15 min and then the ligation was removed. Under anesthesia with urethane, brain tissue was harvested at 0 min (T0), 30 min (T30) and 60 min (T60) after reperfusion. The tissue was embedded in 10% formalin overnight and 4-μm sections were prepared for immunostaining with monoclonal antibodies. Immunostained cells were counted by optical microscopy. The statistical analysis used mean values based on 4 sections. Results The pretreatment with L-Ala-Gln animal group 1 demonstrated significantly lower levels of TNF-α, NF-κB and IL-6. On the other hand, the levels of HO-1 were significantly higher, suggesting a protective role in model of brain ischemia-reperfusion injury. Conclusion These findings suggest a protective effect of L-Ala-Gln by decreasing levels of TNF-alpha, IL-6 and NF-κB and Increasing levels of HO-1.

https://doi.org/10.1590/s0102-865020200060000001 658 downloads

10.

Perdas físicas de imunobiológicos no estado do Ceará, 2014-2016
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Seabra Filho, Francisco Tarcísio

; Moura, Ana Débora Assis

; Braga, Ana Vilma Leite

; Jereissati, Nayara de Castro Costa

; Câncio, Kariny Santos

; Silva, Marcelo Gurgel Carlos da

Epidemiologia e Serviços de Saúde

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2020, Volume 29 N. 2 elocation e2019004

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo: descrever as perdas físicas, por descarte, dos imunobiológicos fornecidos pelo Programa Nacional de Imunizações (PNI) ao estado do Ceará no período 2014-2016, e os custos das doses perdidas. Métodos: estudo descritivo, com dados dos formulários de avaliação de imunobiológicos sob suspeita e dos pareceres favoráveis de descarte. Resultados: foram incluídos 317 formulários, dos quais 72,0% obtiveram parecer de descarte; foram identificadas 160.767 doses perdidas, totalizando um custo de R$ 1.834.604,75; as perdas representaram 0,45%, 0,93% e 0,53% do custo total das vacinas nos anos de 2014, 2015 e 2016, respectivamente; o principal motivo das perdas físicas identificadas foi a falta de energia elétrica (54,9%). Conclusão: identificou-se grande número de doses descartadas por perdas físicas, com elevado custo absoluto; faz-se necessário um controle mais rigoroso, pois falhas na dinâmica de conservação podem interferir na oferta dos imunobiológicos.

Abstract Objective: to describe discarded wasted immunobiological products provided by the National Im-munization Program (PNI) to the State of Ceará between 2014 and 2016, and the costs of discarded doses. Methods: this was a descriptive study using data from suspect im-munobiological product evaluation forms and data from disposal approval forms. Results: a total of 317 forms were included, 72.0% of which had a disposal approval form, and 160,767 discarded doses were identified, at a total cost of BRL 1,834,604.75; wastage accounted for 0.45%, 0.93% and 0.53% of the total cost of vaccines in 2014, 2015 and 2016, respectively; the main reason for the wastage identified was electric power shortage (54.9%). Conclusion: we identified a large number of discarded wasted doses, with high absolute cost; tighter control is necessary, as failures in conservation dynamics may interfere with the supply of immunobiologicals.

Resumen Objetivo: describir las pérdidas físicas por eliminación de inmunobiológicos proporcionados por el Programa Nacional de Inmunización (PNI) al estado de Ceará, en el periodo 2014-2016, y los costos de las dosis omitidas. Métodos: estudio descriptivo, con datos de formula-rios de evaluación de los inmunobiológicos sospechosos y de las opiniones favorables de descarte. Resultados: se incluyeron un total de 317 formularios, de los cuales el 72,0% obtuvo una opinión de descarte, y se identificaron 160.767 dosis omitidas, con un costo total de R$ 1.834.604,75; las pérdidas representaron el 0,45%, el 0,93% y el 0,53% del costo total de las vacunas en 2014, 2015 y 2016, respectivamente; la razón principal de las pérdidas físicas identificadas fue la falta de electricidad (54,9%). Conclusión: iden-tificamos un gran número de dosis descartadas por pérdidas físicas, con un alto costo absoluto; es necesario un control más estricto, ya que las fallas en la dinámica de conser-vación pueden interferir con el suministro de inmunobiológicos.

https://doi.org/10.5123/51679-49742020000200003

11.

Perdas físicas de imunobiológicos no estado do Ceará, 2014-2016
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Seabra Filho, Francisco Tarcísio

; Moura, Ana Débora Assis

; Braga, Ana Vilma Leite

; Jereissati, Nayara de Castro Costa

; Câncio, Kariny Santos

; Silva, Marcelo Gurgel Carlos da

Epidemiologia e Serviços de Saúde

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2020, Volume 29 N. 2 elocation e2019004

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.5123/51679-49742020000200003 430 downloads

12.

RB0442 - drought tolerant sugarcane cultivar
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Diniz, Carlos Assis

; Ferreira, Vilma Marques

; Barbosa, Geraldo Veríssimo de Souza

; Cruz, Marcelo de Menezes

; Silva, José Vieira da

; Santos, João Messias dos

; Teodoro, Iêdo

; Tôrres, Vera Lucia Dubeux

; Soares, Lailton

; Silva, Adeilson Mascarenhas de Oliveira

; Nascimento, Bruno Fernando Costa do

; Sousa, Antônio José Rosário

; Ribeiro, Carlos Alberto Guedes

; Viveiros, Antônio Jorge de Araújo

; Sampaio Filho, Francisco

; Freitas, Edjane Gonçalves de

Crop Breeding and Applied Biotechnology

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dec 2019, Volume 19 N. 4 Pages 466 - 470

Abstract: En | Text: En | PDF: En

Abstract Sugarcane cultivar RB0442 has a high yield, late maturation and good drought tolerance. It is recommended for planting in restrictive environments, mainly with water-deficient soils, and is resistant to the major sugarcane diseases of the Northeastern region of Brazil.

https://doi.org/10.1590/1984-70332019v19n4c66 642 downloads

13.

Application of LC-DAD Metabolic Fingerprinting in Combination with PCA for Evaluation of Seasonality and Extraction Method on the Chemical Composition of Accessions from Lippia alba (Mill) N. E. Brown and Biological Activities
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Jesus, Raphael A. de

; Prado, Vilma M. J.

; Pinto, Vanderson S.

; Silva, Valdenizia R.

; Santos, Luciano S.

; Nogueira, Paulo C. L.

; Navickiene, Sandro

; Pereira-Filho, Edenir R.

; Blank, Arie F.

; Bezerra, Daniel P.

; Soares, Milena B. P.

; Seidl, Claudia

; Cardoso, Carmen L.

; Moraes, Valéria R. S.

Journal of the Brazilian Chemical Society

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may 2019, Volume 30 N. 5 Pages 978 - 987

Abstract: En | Text: En | PDF: En

The methodology developed in this study through the acquisition of fingerprint chromatograms by liquid chromatography-diode array detector (LC-DAD), aided by principal component analysis, made it possible to assess, in a rational way, the chemical differences between six accessions of Lippia alba and to verify the influence of the method of extraction, the seasonality and the individuality of each accession on chemical composition of its extracts. Among all extracts analyzed against cancer cell lines, eight of them showed to be more promising against a human leukemia cell line (HL-60), displaying cell growth inhibition percentage ranging between 40.0 and 52.0%. In the inhibitory activity assays against acetylcholinesterase enzyme, all extracts showed weak inhibitory effect, with highlight only for six of them, which displayed inhibition ranging between 27.0 and 32.0%.

https://doi.org/10.21577/0103-5053.20180244 666 downloads

14.

Prevalence of temporomandibular joint disorder in people with Parkinson’s disease in a public university hospital
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Silva, Renato Mariano da

; Santos, Vilma Lucia dos

; Silva, Taysa Vannoska de Almeida

; Lins, Carla Cabral dos Santos Accioly

Revista CEFAC

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2019, Volume 21 N. 3 elocation e17618

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: avaliar a prevalência de disfunção temporomandibular em pessoas com doença de Parkinson, em um hospital público universitário, e relacioná-los com aspectos sociodemográficos, saúde geral, saúde bucal autopercebida, estágio e tempo de doença. Métodos: utilizou-se o instrumento Critério de Diagnostico para Pesquisa em Disfunção Temporomandibular. A amostra foi estratificada de acordo com o diagnóstico de disfunção temporomandibular e associada com as variáveis. Aplicou-se para análise o odds ratio do Qui-quadrado com intervalo de confiança de 95% com nível de significância de p<0,05. Resultados: foram avaliadas 110 pessoas com doença de Parkinson. A prevalência de disfunção temporomandibular foi de 35%, com maior frequência no sexo masculino (58%), em pessoas idosas (53%), no estágio 2 da doença (61%), sendo que o sinal clínico predominante foi o estalido (37%). Das variáveis analisadas, o sexo e a autopercepção de saúde bucal demonstraram estar associadas à disfunção temporomandibular. Conclusão: verificou-se a presença de disfunção temporomandibular em pessoas com doença de Parkinson, e que os fatores associados foram: ser do sexo masculino e ter autopercepção de saúde oral considerada razoável.

ABSTRACT Objective: to evaluate the prevalence of temporomandibular joint disorder in people with Parkinson’s disease in a public university hospital, and relate it to sociodemographic factors, general health and oral health self-report, and phase and time of illness. Methods: the Research Diagnostic Criteria for Temporomandibular Disorders were used. The sample was classified according to the diagnosis of temporomandibular disorder and associated with the variables. The odds ratio of Chi-square was applied with a 95% confidence interval and a level of significance set at p<0.05. Results: 110 people presented with Parkinson's disease were assessed. The prevalence of temporomandibular disorder was 35%, being more frequent among males (58%), in elderly people (53%), in phase 2 of the disease (61%), click (37%) being the predominant clinical indication. Of the variables analyzed, only gender and self-perception of oral health showed to be associated with temporomandibular disorders. Conclusion: the presence of temporomandibular disorder has been observed in people with Parkinson's disease, and the fact of being male and reporting moderate oral health seen as associated factors.

https://doi.org/10.1590/1982-0216/201921317618 1702 downloads

15.

The QualiRede intervention: improving the performance of care continuum in HIV, congenital syphilis, and hepatitis C in health regions
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Nemes, Maria Ines Battistella

; Castanheira, Elen Rose Lodeiro

; Alves, Ana Maroso

; Adania, Carolina Simone Souza

; Loch, Ana Paula

; Monroe, Aline Aparecida

; Souza, Rosa Alencar

; Gianna, Maria Clara

; Caminada, Sirlene

; Farias, Norma Suely de Oliveira

; Sousa, Paula de Oliveira e

; Domingues, Carmen Silva Bruniera

; Silva, Mariliza Henrique da

; Cervantes, Vilma

; Yamashiro, Juliana

; Caraciolo, Joselita Maria de Magalhães

; Silva, Fabiano Lima da

; Nemes Filho, Alexandre

; Jesus, Gabriel Lima de

; Helena, Ernani Tiaraju de Santa

; Albiero, José Francisco Gontan

; Lima, Marcela Soares Silveira

; Bellenzani, Renata

; Kehrig, Ruth Terezinha

; Vale, Felipe Campos do

; Nunes, Luceime Olivia

; Mendonça, Carolina Siqueira

; Zarili, Thais Fernanda Tortorelli

; Vilela, Mara Cristina

; Dantas, Jean Carlos de Oliveira

; Paula, Ivone de

; Tayra, Ângela

; Coelho, Débora Moraes

; Santos, Glauber Palha dos

; Quevedo, Dulce Castro

; Silva, Marcia Aparecida da

; Silva, Iraci Batista da

; Nasser, Mariana Arantes

; Andrade, Marta Campagnoni

; Santos, Maria Altenfelder

; Mercuri, Juliana

; Trindade, Katia Valeska

; Neves, Maria Aparecida Teixeira das

; Toledo, Renata Villanueva Alves de

; Almeida, Maria Cecília Rossi de

; Lima, Iraty Nunes

Revista Brasileira de Epidemiologia

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2019, Volume 22 Suppl. 1 elocation e190010

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Modelos de cuidado contínuo baseiam recentes estratégias em HIV, infecções sexualmente transmissíveis e hepatite C (HCV). Métodos: Desenvolveram-se modelos de contínuo do cuidado em HIV, HCV e sífilis congênita incluindo todas as etapas da atenção, desde a promoção e a prevenção até o controle clínico/cura. O modelo baseou a intervenção QualiRede, desenvolvida em parceria entre universidade e Sistema Único de Saúde (SUS), direcionada a gestores e demais profissionais de 6 regiões de saúde prioritárias em São Paulo e Santa Catarina. Selecionaram-se indicadores para cada etapa do contínuo do cuidado, provenientes dos sistemas de informação do SUS e dos questionários de avaliação de processo Qualiaids e QualiAB. Os indicadores formaram a base técnica de duas oficinas com profissionais e gestores de cada região: a primeira para identificar problemas e formar um Grupo Técnico Regional; e a segunda para construir planos de ação e metas a fim de melhorar o desempenho regional. Resultados: Os indicadores estão disponíveis no website www.qualirede.org. As oficinas ocorreram em quatro regiões de São Paulo (Alto Tietê, Baixada Santista, Grande ABC e Registro) e uma região de Santa Catarina (Foz do Rio Itajaí), resultando em planos regionais em São Paulo, mas não em Santa Catarina. Observou-se domínio limitado dos novos protocolos para HIV e HCV e uso incipiente de indicadores na rotina dos serviços. Conclusão: Melhorar o desempenho do contínuo do cuidado exige apropriação dos indicadores de desempenho e coordenação integrada dos fluxos de atenção em todos os níveis de gestão.

ABSTRACT Introduction: Care continuum models have supported recent strategies against sexually transmitted diseases, such as HIV and Hepatitis C (HCV). Methods: HIV, HCV, and congenital syphilis care continuum models were developed, including all stages of care, from promotion/prevention to clinical control/cure. The models supported the intervention QualiRede, developed by a University-Brazilian National Health System (SUS) partnership focused on managers and other professionals from six priority health regions in São Paulo and Santa Catarina. Indicators were selected for each stage of the care continuum from the SUS information systems and from the Qualiaids and QualiAB facility’s process evaluation questionnaires. The indicators acted as the technical basis of two workshops with professionals and managers in each region: the first one to identify problems and to create a Regional Technical Group; and the second one to design action plans for improving regional performance. Results: The indicators are available at www.qualirede.org. The workshops took place in the regions of Alto Tietê, Baixada Santista, Grande ABC, and Registro (São Paulo) and of Foz do Rio Itajaí (Santa Catarina), which resulted in regional action plans in São Paulo, but not in Santa Catarina. A lack of awareness was observed regarding the new HIV and HCV protocols, as well as an incipient use of indicators in routine practices. Conclusion: Improving the performance of the care continuum requires appropriation of performance indicators and coordination of care flows at local, regional, and state levels of management.

https://doi.org/10.1590/1980-549720190010.supl.1

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