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Abstract We investigated the Biogran on bone repair and metabolism at several time-intervals upon grafting into rat tibia artificial defects. The biomaterial was thoroughly characterized in vitro, and its dissolution behavior upon immersion was assessed in simulated body fluid (SBF) solution for 1, 3, 7, 14, and 30 days. Biogran was also assessed by in vitro hydroxyapatite formation in SBF solution, which is a marker for bioactive behavior. In vivo, distal and proximal bone defects were performed in the Wistar rat's right tibia and filled according to the experimental groups: I) negative control, no filling; II) positive control, 10 mg of autogenous bone; and III) 10 mg of Biogran. Animals were euthanized at 1, 2, 3, 4, 7, and 10 weeks. Bone neoformation was analyzed using histomorphometry (proximal defect), and local levels of bone morphogenetic protein 2 (BMP-2) were measured using the ELISA assay (distal defect). In vitro, the Biogran sample showed a fast dissolution rate within the first 7 days, parallel to the formation of the hydroxyapatite layer. In vivo, the sample was progressively resorbed at a higher rate within the first month until it became almost absent at week 10th. The sample presented similar or higher bone neoformation concerning the autogenous bone. BMP-2 levels were sustained in the Biogran group (around 200 pg/mg) and detected until the last experimental time with a significant difference compared with the controls. Results suggest Biogran is a candidate for hard tissue engineering even in highly active bone remodeling sites.

https://doi.org/10.1590/1678-4324-2024230003

Factors associated with hospitalizations and deaths of pregnant women from Paraná due to COVID-19: a cross-sectional study
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Bergantini, Larissa Silva

; Ichisato, Sueli Mutsumi Tsukuda

; Salci, Maria Aparecida

; Birolim, Marcela Maria

; Santos, Márcia Lorena Alves dos

; Höring, Carla Franciele

; Rossa, Roberta

; Facchini, Luiz Augusto

Revista Brasileira de Epidemiologia

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2024, Volume 27 elocation e240005

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Analisar os fatores associados à hospitalização em enfermaria e unidade de terapia intensiva (UTI), e ao óbito pela COVID-19 em gestantes com caso confirmado. Métodos: Pesquisa observacional, transversal, realizada com dados de gestantes com caso confirmado para COVID-19 provenientes do Sistema de Informação de Vigilância Epidemiológica da Gripe e do Sistema Estadual Notifica COVID-19, do Paraná. Investigou-se a associação entre variáveis independentes e dependentes (hospitalização em enfermaria e UTI, e óbito) pelo modelo de regressão de Poisson com variância robusta. Resultados: 4.719 gestantes compuseram a população do estudo; 9,6 e 5,1% foram hospitalizadas em enfermaria e UTI, respectivamente; 1,9% evoluíram para óbito. Houve associação entre a idade materna avançada e internação em enfermaria (RP=1,36; IC95% 1,10–1,62) e UTI (RP=2,25; IC95% 1,78–2,71), e óbito (RP=3,22; IC95% 2,30–4,15). Verificou-se associação entre o terceiro trimestre gestacional e hospitalização em enfermaria (RP=5,06; IC95% 2,82–7,30) e UTI (RP=6,03; IC95% 3,67–8,39) e óbito (RP=13,56; IC95% 2,90–24,23). O segundo trimestre associou-se à internação em UTI (RP=2,67; IC95% 1,36–3,99). Gestantes com cardiopatia apresentaram maior frequência de hospitalização em enfermaria (RP=2,24; IC95% 1,43–3,05) e UTI (RP=2,66; IC95% 1,46–3,87). A obesidade foi associada à admissão em UTI (RP=3,79; IC95% 2,71–4,86) e ao óbito (RP=5,62; IC95% 2,41–8,83). Conclusão: A idade materna avançada, o final do período gestacional e comorbidades foram fatores associados a quadros graves de COVID-19.

ABSTRACT Objective: To analyze the factors associated with hospitalization in the ward and intensive care unit (ICU), and with death from COVID-19 in pregnant women with confirmed cases. Methods: Observational, cross-sectional study, carried out with data from pregnant women with a confirmed case of COVID-19 from the Influenza Epidemiological Surveillance Information System and the Paraná’s state COVID-19 notification system. The association between the independent and dependent variables (hospitalization in the ward and ICU, and death) was investigated using the Poisson regression model with robust variance. Results: 4,719 pregnant women comprised the study population. 9.6 and 5.1% were hospitalized in wards and ICU, respectively. 1.9% died. There was an association between advanced maternal age and hospitalization in wards (PR=1.36; 95%CI 1.10–1.62) and ICU (PR=2.25; 95%CI 1.78–2.71), and death (PR=3.22; 95%CI 2.30–4.15). An association was found between the third trimester and hospitalization in wards (PR=5.06; 95%CI 2.82–7.30) and ICU (PR=6.03; 95%CI 3.67–8.39) and death (PR=13.56; 95%CI 2.90–24.23). The second trimester was associated with ICU admission (PR=2.67; 95%CI 1.36–3.99). Pregnant women with cardiovascular disease had a higher frequency of hospitalization in wards (PR=2.24; 95%CI 1.43–3.05) and ICU (PR=2.66; 95%CI 1.46–3.87). Obesity was associated with ICU admission (PR=3.79; 95%CI 2.71–4.86) and death (PR=5.62; 95%CI 2.41–8.83). Conclusions: Advanced maternal age, the end of the gestational period and comorbidities were associated with severe COVID-19.

https://doi.org/10.1590/1980-549720240005

Safe practices for bed bathing in the intensive care unit: validation of a checklist
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Silva, Juliana Cristina

; Felix, Márcia Marques dos Santos

; Gonçalves, Rosa Helena Aparecida

; Calegari, Isadora Braga

; Raponi, Maria Beatriz Guimarães

; Barbosa, Maria Helena

Revista Brasileira de Enfermagem

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2024, Volume 77 N. 1 elocation e20230135

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo: Validar lista de verificación para el baño seguro en pacientes críticos. Métodos: Estudio metodológico y cuantitativo. Se elaboró una lista de verificación para baño seguro en paciente crítico compuesta por 41 ítems, que fue sometida al proceso de validación aparente y de contenido, evaluada por 11 jueces, y confiabilidad interobservadores. Para el análisis de confiabilidad, el instrumento fue aplicado en 54 procedimientos de baño en el lecho en UTI; utilizados las pruebas de Kappa e ICC. Resultados: En la validación aparente y de contenido, fueron realizados ayustes conforme sugestiones de los jueces. Los valores de Kappa variaron de moderado a casi perfecto (0,462 a 0,962); y, en algunos ítems, hubo 100% de concordancia; la confiabilidad del instrumento fue excelente (ICC = 0,962). Conclusión: El instrumento se demostró confiable y de fácil aplicación. Su utilización contribuirá para el baño en el lecho seguro y subsidiará intervenciones que objetiven aumentar la calidad asistencial.

ABSTRACT Objective: To validate a checklist for safe bathing in critically ill patients. Methods: This is a methodological and quantitative study. Researchers developed a checklist for safe bathing in critically ill patients consisting of 41 items, which were submitted to the apparent and content validation process, evaluated by eleven judges, and interobserver reliability. For reliability analysis, the instrument was applied in 54 bed bath procedures in the ICU; Kappa and CHF tests were used. Results: In the apparent and content validation, adjustments were made according to the judges’ suggestions. Kappa values ranged from moderate to almost perfect (0.462 to 0.962), and, in some items, there was 100% agreement; the reliability of the instrument was excellent (ICC = 0.962). Conclusion: The instrument proved to be dependable and easy to apply. Its use will contribute to safe bed bathing and subsidize interventions aimed at increasing the quality of care.

RESUMO Objetivo: Validar uma lista de verificação para o banho seguro em pacientes críticos. Métodos: Estudo metodológico e quantitativo. Elaborou-se uma lista de verificação para banho seguro no paciente crítico composta por 41 itens, que foi submetida ao processo de validação aparente e de conteúdo, avaliada por 11 juízes, e confiabilidade interobservadores. Para a análise de confiabilidade, o instrumento foi aplicado em 54 procedimentos de banho no leito em UTI; utilizaram-se os testes de Kappa e ICC. Resultados: Na validação aparente e de conteúdo, foram realizados ajustes conforme sugestões dos juízes. Os valores de Kappa variaram de moderado a quase perfeito (0,462 a 0,962); e, em alguns itens, houve 100% de concordância; a confiabilidade do instrumento foi excelente (ICC = 0,962). Conclusão: O instrumento demonstrou-se confiável e de fácil aplicação. Sua utilização contribuirá para o banho no leito seguro e subsidiará intervenções que visem aumentar a qualidade assistencial.

https://doi.org/10.1590/0034-7167-2023-0135

Global research trends related to coronavirus disease 2019 and the aged: a bibliometric analysis
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Carvalho, Ana Raquel Batista de

; Sousa Neto, Antonio Rosa de

; Silva, Márcia Daiane Ferreira da

; Freitas, Daniela Reis Joaquim de

; Moura, Maria Eliete Batista

Sao Paulo Medical Journal

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2024, Volume 142 N. 2 elocation e2022662

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: A bibliometric analysis covering only the production of original studies or considering world production until 2022 has yet to be conducted. The creation and advancement of vaccines have also influenced research priorities, demonstrating the need for a new approach to this subject. OBJECTIVES: To analyze worldwide scientific production related to coronavirus disease 2019 (COVID-19) and the aged and to describe what has already been produced. DESIGN AND SETTING: Bibliometric analysis with a quantitative approach. METHOD: The search terms “COVID-19,” “SARS-CoV-2,” “Aged,” and “Elderly” were used to retrieve articles from the Web of Science database. A total of 684 articles were included in the analysis. Data were imported into RStudio Desktop Software and linked to R Software. The Bibliometrix R package and VOSviewer software were used for analysis. RESULTS: Most articles were published in 2020. These were produced by 4,937 authors and published in 379 journals. The keyword most used by the authors was “COVID-19.” Publications from 77 countries were obtained. China had the highest article production ranking, and Spain collaborated the most. The articles addressed the implications of the pandemic on the aged, the relationship between vaccination in the aged, and the implications for the disease itself. CONCLUSION: Further research should be conducted, mainly concerning vaccines and vaccination of the aged, owing to the need for and importance of immunization in this risk group, including assessing the long-term effects of vaccines.

https://doi.org/10.1590/1516-3180.2022.0662.r1.190523

Autoinflammatory diseases: a Latin American multicenter study according to age and sex
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Piotto, Daniela Gerent Petry

; Kozu, Katia

; Aikawa, Nádia Emi

; Carneiro, Pedro Lopes

; Katsicas, María Martha

; Oliveira, Sheila Knupp Feitosa de

; Fernandes, Taciana de Albuquerque Pedrosa

; Magalhães, Claudia Saad

; Cunha, Ana Luiza Garcia

; Bica, Blanca Elena Rios Gomes

; Rabelo Júnior, Carlos Nobre

; Battagliotti, Cristina

; Matos, Erica Naomi Naka

; Santos, Flavia Patrícia Sena Teixeira

; Sztajnbok, Flavio Roberto

; Bezrodnik, Liliana

; Bandeira, Marcia

; Rodrigues, Marta Cristine Felix

; Munittis, Pablo García

; Appenzeller, Simone

; Robazzi, Teresa Cristina Martins

; Clemente, Gleice

; Silva, Clovis Artur

; Terreri, Maria Teresa

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2022184

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, and response to therapy in a large population. Methods: This is a cross-sectional observational study of a Latin American registry using a designed web system for data storage, collected between 2015 and 2018. Any altered findings during follow-up were recorded. The forms were translated into Portuguese and Spanish, including demographic, clinical, laboratory, genetic and treatment characteristics. Results: We included 152 patients, 51.3% male and 75% Caucasian. The median age at disease onset was 2.1 years (0–15.6 years) and median age at diagnosis 6.9 years (0–21.9 years); 111 (73%) were children (0–9 years old), and 41 (27%) were adolescents and young adults (AYA) (10–21 years old). Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) occurred in 46/152 (30%), chronic non-bacterial osteomyelitis (CNO) in 32/152 (21%), and familial Mediterranean fever (FMF) in 24/152 (15.7%). PFAPA was significantly higher in young children than in AYA (38.7% vs. 7.3%, p<0.001), while CNO were lower (13.5% vs. 41.5%, p<0.001). The frequency of females was significantly higher in CNO (28.4% vs. 14.1%, p=0.031) and lower in FMF (8.1% vs. 23.1%, p=0.011). The most used drugs were glucocorticoids, non-steroidal anti-inflammatory drugs (NSAID), and colchicine. Glucocorticoids and colchicine treatment were used in all AID with good to moderate response. However, cryopyrin-associated periodic syndromes (CAPS) seemed unresponsive to glucocorticoids. NSAIDs and methotrexate were the main medications used to treat CNO. Conclusions: Differences among AID patients were observed in the LA population regarding sex and age at disease diagnosis.

RESUMO Objetivo: Avaliar as doenças autoinflamatórias (DAI) de acordo com sexo e idade no momento do diagnóstico e a resposta terapêutica em uma grande população. Métodos: Este é um estudo observacional transversal de um registro latino-americano que usou um sistema de dados coletados entre 2015 e 2018. Quaisquer achados alterados ao longo do acompanhamento foram registrados. Os formulários foram traduzidos para os idiomas português e espanhol, incluindo características demográficas, clínicas, laboratoriais, genéticas e de tratamento. Resultados: Incluímos 152 pacientes, sendo 51,3% do sexo masculino e 75% da raça branca. A média de idade de início da doença foi de 2,1 anos (0–15,6 anos) e a média de idade de diagnóstico 6,9 anos (0–21,9 anos); 111 (73%) eram crianças (0–9 anos) e 41 (27%) adolescentes/adultos jovens (10–21 anos). A síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA) ocorreu em 46/152 (30%), osteomielite não bacteriana crônica (CNO) em 32/152 (21%) e febre familiar do Mediterrâneo (FMF) em 24/152 (15,7%). A PFAPA foi significativamente maior em crianças pequenas (38,7 vs. 7,3%, p<0,001), e a CNO, em adolescentes/adultos jovens (13,5 vs. 41,5%, p<0,001). A frequência do sexo feminino foi significativamente maior na CNO (28,4 vs. 14,1%, p=0,031) e menor na FMF (8,1 vs. 23,1%, p=0,011). Os medicamentos mais utilizados foram glicocorticoides, anti-inflamatórios não esteroidais (AINE) e colchicina. O tratamento com glicocorticoides e colchicina foi usado em todas as DAI com resposta boa a moderada. No entanto, as síndromes periódicas associadas à criopirina (CAPS) pareciam não responder aos glicocorticoides. AINE e metotrexato foram os principais medicamentos utilizados no tratamento da CNO. Conclusões: Diferenças de pacientes com DAI foram observadas na população latino-americana em pacientes agrupados por sexo e idade ao diagnóstico da doença.

https://doi.org/10.1590/1984-0462/2024/42/2022184

Fatores de risco à saúde mental dos profissionais da saúde durante a pandemia de COVID-19: revisão sistemática
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Silva, Mariane Alexandra Xavier da

; Santos, Mairana Maria Angélica

; Araújo, Angélica Barros

; Galvão, Cláudia Regina Cabral

; Barros, Márcia Maria Mont’Alverne de

; Silva, Ana Cristina de Oliveira e

; Souza, Marina Batista Chaves Azevedo de

; Barroso, Bárbara Iansã de Lima

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 3033 - 3044

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Neste estudo, nosso objetivo foi mapear as evidências disponíveis sobre os fatores de risco à saúde mental dos profissionais de saúde trabalhadores da linha de frente durante a pandemia de COVID-19. Trata-se de uma revisão sistemática que seguiu os critérios dos Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A busca foi realizada independentemente, por quatro pesquisadores, seguindo os critérios de seleção nas bases de dados eletrônicas PubMed Central, Ovid Technologies, GALE Academic Onefile, Science Citation Index Expanded. No processamento de dados foi utilizado o software Zotero, responsável por criar e importar itens de acordo com os critérios estabelecidos pela pesquisa. Foram encontrados 18.733 artigos, dos quais 2.722 foram excluídos, a partir do programa Zotero, por estarem duplicados, e outros 366 excluídos manualmente. Após aplicação dos critérios de seleção, 43 artigos entraram na análise final desta revisão. Recomenda-se a elaboração de novas pesquisas científicas, sobretudo colocando como objeto a análise da saúde mental desses trabalhadores, com o objetivo de embasar a elaboração e implementação de programas e políticas públicas de saúde mental para os trabalhadores.

Abstract The aim of the present study was to map the available evidence on the mental health risk factors of frontline health professionals during the COVID-19 pandemic. This is a systematic review that followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The search was independently carried out by four researchers, following the selection criteria in the electronic databases: PubMed Central, Ovid Technologies, GALE Academic Onefile, Science Citation Index Expanded. The data processing used Zotero software, responsible for creating and importing items according to the criteria established by the research. A total of 18,733 articles were found, of which 2,722 were excluded by the Zotero software because they were in duplicate, and another 366 were manually excluded. After applying the selection criteria, 43 articles entered the final analysis of this review. It is recommended that new scientific research be carried out, especially focusing on the analysis of health workers’ mental health, aiming at providing the basis to create and implement public mental health programs and policies for workers.

https://doi.org/10.1590/1413-812320232810.12102023

Fatores de risco à saúde mental dos profissionais da saúde durante a pandemia de COVID-19: revisão sistemática
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Silva, Mariane Alexandra Xavier da

; Santos, Mairana Maria Angélica

; Araújo, Angélica Barros

; Galvão, Cláudia Regina Cabral

; Barros, Márcia Maria Mont’Alverne de

; Silva, Ana Cristina de Oliveira e

; Souza, Marina Batista Chaves Azevedo de

; Barroso, Bárbara Iansã de Lima

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 3033 - 3044

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-812320232810.12102023

Station Rotation: an Experience Report of a Teaching-Learning Proposal in Youth and Adult Education
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Aparecida da Silva, Regiane

; Maria Felício, Cínthia

; Ferreira-Silva, Regina Márcia

; Ferreira, Julio Cesar

; Noll, Matias

Revista Electrónica Educare

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apr 2023, Volume 27 N. 1 Pages 317 - 337

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective: The objective of this investigation was to verify the possibilities and potentialities of the use of active methodologies (AM), with a focus on rotation by stations, in Youth and Adult Education (YAE). The study also aimed to suggest AM as a proposal that collaborates with quality in teaching-learning and can contribute to students becoming autonomous subjects. Since it is an audience that needs more attention from researchers in the area of education, from this the practice in question was carried out in a six-class municipal school with 112 students in the center-west of Goiás. The class chosen for the practice has 28 students enrolled, and two are from Inclusive Education. Methodology: In the data collection, we used questionnaires, and the data collected were analyzed in a discursive way. For this research, we used a qualitative approach of the descriptive type and documental analysis of public policies. Conclusions: It is concluded that the applied practice must gradually be inserted into the education of young people and adults, collaborating with the student to facilitate learning and with the teacher, who is always looking for new ways to meet your student.

Resumen Objetivo: El objetivo de esta investigación fue verificar las posibilidades y potencialidades del uso de metodologías activas (AM), con enfoque de rotación por estaciones, en la educación de personas jóvenes y adultas (EJA), además de sugerir AM como una propuesta que colabora con calidad en la enseñanza-aprendizaje y puede contribuir a que el estudiantado se convierta en autónomo. Por tratarse de un público que necesita más atención de las personas investigadoras en el área de la educación, a partir de eso, la práctica en cuestión fue realizada en una escuela municipal, en el centro-oeste de Goiás, y cuenta con seis clases, en un total de 112 estudiantes. El curso escogido para la práctica tiene 28 estudiantes com matrícula, dos de em educación inclusiva. Metodología: En la recolección de datos se utilizaron cuestionarios y los datos de estos cuestionarios fueron analizados de forma discursiva, se utilizó un enfoque cualitativo, de tipo descriptivo y análisis documental de políticas públicas. Conclusión: Se concluye que la práctica aplicada debe insertarse en la formación de jóvenes y personas adultas de forma paulatina, y colaborar con el estudiantado, con el fin de facilitar su aprendizaje, como con el personal docente, que siempre está buscando nuevas formas de satisfacer sus necesidades.

Resumo Objetivo: O objetivo desta pesquisa foi verificar as possibilidades e potencialidades do uso de metodologias ativas (AM), com foco na rotação por estações, na educação de jovens e adultos (EJA), além de sugerir as MA como proposta que colabora com a qualidade no ensino-aprendizagem e pode contribuir para que os estudantes se tornem autônomos. Como este é um público que precisa de mais atenção dos pesquisadores na área da educação, a partir disto, a prática em questão foi realizada em uma escola municipal, no centro-oeste goiano, e conta com seis classes, num total de 112 alunos. A classe escolhida para a prática tem 28 alunos matriculados, dois deles em educação inclusiva. Metodología: Na coleta de dados utilizamos questionários e os dados destes questionários foram analisados de forma discursiva. Para esta pesquisa foi utilizado a abordagem qualitativa, do tipo descritiva e análise documental de políticas públicas. Conclusão: Conclui-se que a prática aplicada deve ser inserida na educação de jovens e adultos de forma gradual, e colaborar com os estudantes, com o objetivo de facilitar sua aprendizagem, assim como com o corpo docente, que está sempre em busca de novas formas para atender seu alunado.

https://doi.org/10.15359/ree.27-1.14472

Body fat, cardiovascular risk factors and polymorphism in the FTO gene: randomized clinical trial and different physical exercise for adolescents
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Bila, Wendell C.

; Romano, Márcia C.C.

; Santos, Luciana L. dos

; Silva, Valmin R. da

; Capanema, Flavio D.

; Pfrimer, Karina

; Ferriolli, Eduardo

; Alves, Natália M.C.

; Campos, Cezenário G.

; Carlos, Fabiângelo M.

; Santos, Maria E.S.M. dos

; Lamounier, Joel A.

Jornal de Pediatria

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apr 2023, Volume 99 N. 2 Pages 139 - 146

Abstract: En | Text: En | PDF: En

Abstract Objective: To investigate the effects of different physical exercise programs and polymorphisms of the FTO (fat mass and obesity-associated gene) on body composition and cardiovascular risk factors in adolescents with overweight and obesity. Methods: A randomized, parallel, double-blind clinical trial consisting of the adolescent overweight from the state public network, in a simple representative random sample, who participated in an aerobic exercise or weight training intervention for 10 weeks. Anthropometry, body composition, biochemical markers, sexual maturation, and rs9939609 polymorphism in the FTO gene were assessed. 347 adolescents had their characterization of nutritional status. 72 individuals with overweight and obesity were invited to participate. 39 remained for the start of the program and were randomly allocated to both types of intervention. In the end, 26 subjects participated in the intervention programs, with 12 and 14 in the aerobic and weight training programs, respectively. Results: Heterozygous and homozygous bearers of risk allele A participating in the aerobic program showed improvements in glycemia (p = 0.002) and total cholesterol (p = 0.023) and a reduction in body fat mass (p = 0.041). The weight training program reduced glycemia in patients with the risk allele A (p = 0.027). Cameron’s stage four sexual maturation participants were 2.1 times more likely to improve their body fat (CI = 1.31–3.39). Conclusion: Aerobic exercises produced exclusively a significant decrease in fat mass and total cholesterol in patients with risk allele A. Distinct physical exercise programs may cause diverse changes in risk variables related to the health of adolescents.

https://doi.org/10.1016/j.jped.2022.07.004

10.

Inflammatory Fibrous Hyperplasia Associated with Chondroid Metaplasia - Report and Morphological Analysis of Five Cases
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da-Silva-Barros, Caio César

; Medeiros, Maurília Raquel de Souto

; Rêgo, Delane Maria

; Miguel, Márcia Cristina da Costa

; da-Silveira, Éricka Janine Dantas

International journal of odontostomatology

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mar 2023, Volume 17 N. 1 Pages 101 - 106

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN: La hiperplasia fibrosa inflamatoria (HFI) es una lesión reactiva común en los usuarios de prótesis dentales que puede estar asociada con la metaplasia cartilaginosa (MC). La metaplasia es un proceso celular adaptativo que puede ser causado por un trauma. El presente informe analizó cinco casos de HFI asociados a MC y se analizaron morfológicamente la deposición de colágeno en estas lesiones. Los pacientes tenían una edad media de 58,8 años y eran usuarios de prótesis dentales mal adaptadas. Se observaron lesiones nodulares localizadas en el la parte anterior del maxilar Microscópicamente se observó tejido conectivo fibroso hiperplásico con infiltrado inflamatorio crónico y cartílago hialino. No se observaron diferencias morfológicas en la deposición de colágeno bajo microscopía óptica, pero el análisis cuantitativo reveló una deposición de colágeno significativamente mayor en el tejido conectivo cerca de MC (p = 0,015). La HFI asociada con la MC afecta a los usuarios de prótesis dentales mal adaptadas. La presencia de MC no es significativa para el pronóstico de la lesión. Sin embargo, su formación y la mayor deposición de colágeno cerca de MC refuerza el origen reactivo de HFI.

ABSTRACT: Inflammatory fibrous hyperplasia (IFH) is a common reactive lesion in dental prostheses users that may be associated with chondroid metaplasia (CM). Metaplasia is an adaptive cellular process that may be caused by trauma. We reported here five cases of IFH associated with CM and analyzed morphologically the deposition of collagen in these lesions. Patients had a mean age of 58.8 years-old and were ill-fitting dental prostheses users. They presented nodular lesions located in the anterior maxilla. Microscopically, it was observed hyperplastic fibrous connective tissue with chronic inflammatory infiltrate and hyaline cartilage. No morphological differences were observed in collagen deposition under light microscopy, but quantitative analysis revealed a significantly higher collagen deposition at the connective tissue near CM (p = 0.015). IFH associated with CM affects ill-fitting dental prostheses users. The presence of CM is not significant to the lesion prognosis. However, its formation and the higher collagen deposition near it reinforces the IFH reactive origin.

11.

Atenção Primária à Saúde em municípios rurais remotos brasileiros: contexto, organização e acesso à atenção integral no Sistema Único de Saúde
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Fausto, Márcia Cristina Rodrigues

; Almeida, Patty Fidelis de

; Bousquat, Aylene

; Lima, Juliana Gagno

; Santos, Adriano Maia dos

; Seidl, Helena

; Mendonça, Maria Helena Magalhães de

; Cabral, Lucas Manoel da Silva

; Giovanella, Ligia

Saúde e Sociedade

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2023, Volume 32 N. 1 elocation e220382pt

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A despeito da diversidade socioespacial, localidades rurais remotas têm em comum pequenos povoados dispersos em um vasto território, populações isoladas e longas distâncias em relação aos centros urbanos. O objetivo do estudo é analisar as especificidades da organização e do acesso à atenção primária à saúde (APS) no Sistema Único de Saúde (SUS) em municípios rurais remotos (MRR) brasileiros. Para tanto, realizou-se um estudo de abordagem qualitativa, com base em estudo de casos múltiplos em 27 MRR. Foi feita uma análise de conteúdo temática de 211 entrevistas semiestruturadas com gestores e profissionais de saúde, e uma triangulação de informações para explorar e reconhecer as formas de organização, estratégias e desafios para o acesso à saúde. Os resultados indicam que: as características dos contextos rurais remotos condicionam a provisão da APS; há diferenças nas formas de ofertar ações de saúde e maiores falhas de cobertura assistencial nas áreas mais rarefeitas e remotas dos municípios; existem contradições entre o financiamento da APS nacional e as características dos territórios marcado por rarefação populacional e longas distâncias; e a escassez da força de trabalho é um desafio comum nos municípios estudados. É necessário, portanto, considerar as características territoriais, sociais e de acesso aos serviços de saúde para a proposição de políticas públicas que atendam às necessidades dos MRR.

Abstract Despite the socio-spatial diversity, remote rural locations have in common small villages dispersed over a vast territory, isolated populations, and long distances from urban centers. The objective of the study is to analyze the specificities of the organization and access to primary health care (PHC) in the Brazilian National Health System (SUS) in remote rural municipalities (MRR). To that end a study with a qualitative approach, based on a multiple case study in 27 MRR was carried out. Thematic content analysis of 211 semi-structured interviews with managers and health professionals and a triangulation of information to explore and recognize the forms of organization, strategies, and challenges for the access to health were performed. The results indicate that: the characteristics of remote rural contexts condition the provision of PHC; there are differences in the ways of offering health actions and greater gaps in care coverage in the most rarefied and remote areas of the municipalities; there are contradictions between national PHC funding and the characteristics of territories marked by sparcely populated areas and long distances; and the shortage of the workforce is a common challenge among the cities studied. It is, thus, necessary to consider the territorial, social, and access characteristics to health services to propose public policies that meet the needs of the MRR.

https://doi.org/10.1590/s0104-12902023220382pt

12.

Seroprevalence of SARS-CoV-2 antibodies in schoolchildren in the city of São Paulo, 2020
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Kamioka, Gabriela Akemi

; Madalosso, Geraldine

; Albuquerque, José Olimpio Moura de

; Costa, Selma Anequini

; Ferreira, Paula Bisordi

; Sato, Ana Paula Sayuri

; Glasser, Paula Regina

; Pino, Francisco Alberto

; Burihan, Patrícia Carla Piragibe Ramos

; Carvalho, Ana Carolina Aguiar de

; Amorim, Ana Beatriz Pagliaro

; Cavazzana, Cinthya Luzia

; Aires, Caroline Cotrim

; Kataoka, Ana Paula Arruda Geraldes

; Savani, Elisa San Martin Mouriz

; Bessa, Thirsa Alvares Franco

; Aguiar, Breno Souza de

; Failla, Marcelo Antunes

; Santos, Edson Aparecido dos

; Brito, Edjane Maria Torreão

; Santos, Maria Cristina Honório dos

; Caldeira, Luiz Artur Vieira

; Silva, Solange Maria Saboia e

; Zamarco, Luiz Carlos

; Fonseca, Sandra Maria Sabino

; Lima, Marcia Maria de Cerqueira

; Marques, Ivanilda Argenau

; Mauro, Athenê Maria de Marco França

; Masi, Eduardo de

Revista de Saúde Pública

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2023, Volume 57 Suppl. 1 elocation 6s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Estimar a soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares de quatro a 14 anos de idade residentes no município de São Paulo, segundo variáveis clínicas, demográficas, epidemiológicas e sociais, durante o período de fechamento das escolas como medida de controle da covid-19. MÉTODOS Realizou-se um inquérito sorológico em setembro de 2020 com amostra aleatória estratificada por tipo de rede de ensino (pública municipal, pública estadual e privada). Foi coletada amostra de sangue venoso utilizando-se o teste de imunoensaio de fluxo lateral da fabricante Wondfo para detecção de anticorpos totais contra o vírus SARS-CoV-2. Aplicaram-se questionários semiestruturados para o levantamento de dados clínicos, demográficos, sociais e epidemiológicos. RESULTADOS A soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares foi de 16,6% (IC95% 15,4–17,8). O estudo encontrou soroprevalências mais elevadas na rede pública municipal (18,5%; IC95% 16,6–20,6) e estadual (16,2%; IC95% 14,4–18,2) em relação à rede privada (11,7; IC95% 10,0–13,7) e entre escolares da raça/cor preta e parda (18,4%; IC95% 16,8–20,2) e no estrato social mais vulnerável (18,5%; IC95% 16,9–20,2). A pesquisa identificou menores soroprevalências nos escolares que relataram seguir as medidas recomendadas de proteção contra a covid-19. CONCLUSÃO A soroprevalência de anticorpos contra o vírus SARS-CoV-2 atinge principalmente os escolares socialmente mais vulneráveis. Este estudo pode contribuir para embasar políticas públicas que reforcem a importância da suspensão das aulas presenciais e da necessidade de estratégias de medidas de proteção e acompanhamento do status sorológico daqueles que ainda não foram contemplados no calendário vacinal.

ABSTRACT OBJECTIVE To estimate seroprevalence of SARS-CoV-2 antibodies in schoolchildren aged 4 to 14 years living in the city of São Paulo, according to clinical, demographic, epidemiological, and social variables, during the school closure period as a measure against covid-19 spread. METHODS A serological survey was made in September 2020 with a random sample stratified by school system (municipal public, state public and private) type. A venous blood sample was collected using the Wondfo SARS-CoV-2 Antibody Test (lateral flow method) for detection of total SARS-CoV-2 virus antibodies. Semi-structured questionnaires were applied to collect clinical, demographic, social, and epidemiological data. RESULTS Seroprevalence of SARS-CoV-2 antibodies in schoolchildren was of 16.6% (95%CI 15.4–17.8). The study found higher seroprevalence in the municipal (18.5%; 95%CI 16.6–20.6) and state (16.2%; 95%CI 14.4–18.2) public school systems compared to the private school system (11.7; 95%CI 10.0–13.7), among black and brown students (18.4%; 95%CI 16.8–20.2) and in the most vulnerable social stratum (18.5 %;95%CI 16.9–20.2). Lower seroprevalence was identified in schoolchildren who reported following the recommended protective measures against covid-19. CONCLUSION Seroprevalence of SARS-CoV-2 antibodies is found mainly in the most socially vulnerable schoolchildren. This study can contribute to support public policies that reinforce the importance of suspending face-to-face classes and developing strategies aimed at protective measures and monitoring of the serological status of those who have not yet been included in the vaccination schedule.

https://doi.org/10.11606/s1518-8787.2023057004782

13.

Adaptation and indication of forage crops for agricultural production in sandy soils in western Bahia State, Brazil
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Simeão, Rosangela Maria

; Silva, Dagma Dionísia da

; Santos, Flávia Cristina dos

; Vilela, Lourival

; Silveira, Márcia Cristina Teixeira da

; Resende, Anna Carolina

; Albuquerque, Paulo Emílio Pereira de

Acta Scientiarum. Agronomy

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2023, Volume 45 elocation e56144

Abstract: En | Text: En | PDF: En

ABSTRACT. The diversity of soils and climate in Brazil imposes the need to evaluate the adaptation of fodder species to soil and climate conditions to guide producers and technicians in choosing the best alternatives for their region. The objective of this study was to evaluate and identify fodder cultivars for pasture and soil cover with tolerance to drought and high production in the sandy soils of southern Bahia, Brazil. The performance of 29 commercial cultivars of perennial and annual tropical forage species was evaluated in six cuts in 2019 and 2020. The green and dry mass yield per cut and the daily dry matter accumulation rate were evaluated considering the periods of water surplus and deficit and the drought tolerance index for each cultivar was estimated. Grass and legume cultivars showed differences in establishment, yield in the water surplus, and in the re-establishment after the water deficit. Based on the values of the drought tolerance index and in the dry mass daily yields before and after the water deficit, the cultivars adapted and indicated for regional continuous grazing were Xaraés, Marandu, Massai, Tanzânia, Paiaguás, and Zuri, in that order. The grasses B. ruziziensis and B. decumbens were indicated for use as cover plants after the harvest due to their high capacity of establishment and short-term production. The annual and perennial legume plants were also indicated for cover, and the combination of cultivars and their potential for straw in direct planting or use in integrated systems still need to be validated.

https://doi.org/10.4025/actasciagron.v45i1.56144

14.

Saúde mental de agentes comunitários de saúde no contexto da COVID-19
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Vieira-Meyer, Anya Pimentel Gomes Fernandes

; Farias, Sidney Feitoza

; Forte, Franklin Delano Soares

; Costa, Milena Silva

; Guimarães, José Maria Ximenes

; Morais, Ana Patrícia Pereira

; Oliveira, André Luiz Sá de

; Silva Júnior, Fernando José Guedes da

; Nascimento, Elaine Ferreira do

; Vasconcelos, Maristela Inês Osawa

; Dias, Maria Socorro de Araújo

; Oliveira, Felipe Proenço de

; Machado, Maria de Fátima Antero Sousa

; Castro, Marcia C.

; Yousafzai, Aisha Khizar

Ciência & Saúde Coletiva

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2023, Volume 28 N. 8 Pages 2363 - 2376

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi analisar os fatores relacionados à saúde mental dos agentes comunitários de saúde (ACS) no contexto da COVID-19. Participaram 1.935 ACS de quatro capitais nordestinas e de quatro cidades do interior do Ceará. Foram coletados dados sociodemográficos e profissiográficos; SRQ-20; WHOQOL-Bref; exposição à violência; Escala de Autoeficácia Geral (EAEG); Escala Multidimensional de Suporte Social Percebido (MSPSS); informações relacionadas à COVID-19 e Escala de Ansiedade para Coronavírus (EAC). 40,5% exibiram SRQ > 7, sinalizando altos níveis de transtornos mentais comuns (TMC)/problemas de saúde mental. Utilizou-se a regressão linear múltiplas (backward). Observou-se que o aumento de risco de TCM foi influenciado pelos seguintes fatores: exposição à violência; EAC; não saber se teve COVID-19; desconhecer as variáveis que diminuíam o risco; os domínios físico e psicológico do WHOQOL-Bref; não ter aumento da jornada de trabalho; e não ter tido COVID-19. Os dados revelam a dinâmica multidimensional da saúde mental e ajudam a compreender a relação entre violência comunitária, COVID-19, qualidade de vida, idade e tempo de atuação na ESF com a saúde mental dos ACS.

Abstract This study aimed to analyze the factors related to the mental health of Community Health Workers (ACS) in the COVID-19 context. A total of 1,935 ACS from four Northeastern capitals and four cities in the inland region of Ceará participated. The following data were collected: sociodemographic; professional; SRQ-20; WHOQOL-Bref, exposure to violence, General Self-Efficacy Scale (EAEG), Multidimensional Scale of Perceived Social Support (MSPSS), COVID-19-related information, and the coronavirus anxiety scale (EAC). Approximately 40.5% had SRQ > 7, signaling high levels of Common Mental Disorders (CMD)/mental health issues. We adopted the Multiple linear (backward) regression. We observed that the increased risk of CMD was influenced by exposure to violence, EAC, not knowing they had COVID-19, not knowing the variables that reduced the risk, the physical and psychological domains of the WHOQOL-Bref, not having increased working hours, and not having had COVID-19. The data reveal the multidimensional dynamics of mental health and help understand the relationship between community violence, COVID-19, quality of life, age, and ESF working time with the mental health of ACS.

https://doi.org/10.1590/1413-81232023288.06462023

15.

Community health workers perspective on the COVID-19 impact on primary health care in Northeastern Brazil
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Vieira-Meyer, Anya Pimentel Gomes Fernandes

; Forte, Franklin Delano Soares

; Guimarães, José Maria Ximenes

; Farias, Sidney Feitoza

; Oliveira, André Luiz Sá de

; Dias, Maria Socorro de Araújo

; Monteiro, Claudete Ferreira de Souza

; Guedes da Silva Júnior, Fernando José

; Morais, Ana Patrícia Pereira

; Moreira, Maria Rosilene Candido

; Castro, Márcia C.

; Yousafzai, Aisha Khizar

Cadernos de Saúde Pública

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2023, Volume 39 N. 7 elocation e00007223

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo: Este artigo avalia as repercussões da pandemia da COVID-19 no cotidiano de trabalho da equipe da Estratégia Saúde da Família (ESF) em diversos municípios do Nordeste brasileiro, na perspectiva dos agentes comunitários de saúde (ACS). Um questionário estruturado foi utilizado para coletar informações sobre a COVID-19, atividades dos ACS e equipes da ESF em 2021. Participaram 1.935 ACS de quatro capitais (Fortaleza - Ceará, João Pessoa - Paraíba, Recife - Pernambuco e Teresina - Piauí) e quatro cidades do interior (Crato, Juazeiro do Norte, Barbalha e Sobral, Ceará). A idade média dos ACS era de 46,25±8,54 anos, sendo a maioria mulheres (82,42%). Muitos (39,92%) estavam infectados com COVID-19, dos quais 70,78% acreditavam ter sido infectados no ambiente de trabalho. Ao todo, 77,82% definiam seu papel como linha de frente no combate à COVID-19, 16,07% relataram receber treinamento para a COVID-19 e 13,74% tinham acesso a equipamentos de proteção suficientes contra a COVID-19. A maioria (90,27%) acredita que suas rotinas de trabalho foram modificadas pela pandemia, fortalecendo o espírito de equipe (41,46%) ou enfraquecendo-o (44,41%). Houve uma redução na promoção da saúde nas escolas (75,66%) e na frequência de visitas domiciliares (60,55%), de grupos específicos na comunidade (93,96%) e outros serviços comunitários locais (66,01%). Nos municípios avaliados, observou-se uma heterogeneidade significativa em relação à resposta à pandemia de COVID-19, possivelmente associada à falta de coordenação do Governo Federal. A pandemia levou a uma reconfiguração dos sistemas locais de saúde, fluxos de trabalho e protocolos de atenção primária para as equipes da ESF. A importância do Sistema Único de Saúde (SUS) e seu potencial de reorganização durante as crises devem ser reconhecidos, preservando-se os avanços alcançados até o momento.

Resumen: Este artículo evalúa las repercusiones de la pandemia de COVID-19 en el trabajo cotidiano del equipo de la Estrategia Salud de la Familia (ESF) en diversos municipios del Nordeste brasileño, desde la perspectiva de los agentes comunitarios de salud (ACS). Se utilizó un cuestionario estructurado para recopilar información sobre COVID-19, actividades de los ACS y equipos de la ESF en el 2021. Participaron 1.935 ACS de cuatro capitales (Fortaleza - Ceará, João Pessoa - Paraíba, Recife - Pernambuco y Teresina - Piauí) y cuatro ciudades del interior (Crato, Juazeiro do Norte, Barbalha y Sobral - Ceará). La edad media de los ACS era de 46,25±8,54 años, y la mayoría eran mujeres (82,42%). Muchos (39,92%) estaban infectados con COVID-19, de los cuales el 70,78% creía haberse contagiado en el entorno laboral. En total, el 77,82% definió su papel como línea de frente en el combate a la COVID-19, el 16,07% informó haber recibido capacitación para la COVID-19 y el 13,74% tuvo acceso a equipos de protección suficiente contra la COVID-19. La mayoría (90,27%) cree que sus rutinas de trabajo se vieron modificadas por la pandemia, fortaleciendo el espíritu de equipo (41,46%) o debilitándolo (44,41%). Hubo una reducción en la promoción de la salud en las escuelas (75,66%) y en la frecuencia de las visitas domiciliarias (60,55%), de grupos específicos en la comunidad (93,96%) y otros servicios comunitarios locales (66,01%). En los municipios analizados, se observó una heterogeneidad significativa con relación a la respuesta a la pandemia de COVID-19, posiblemente asociada a la falta de coordinación del Gobierno Federal. La pandemia condujo a una reconfiguración de los sistemas locales de salud, los flujos de trabajo y los protocolos de atención primaria para los equipos de la ESF. Se debe reconocer la importancia del Sistema Único de Salud y (SUS) su capacidad de reorganización durante las crisis, preservando los avances logrados hasta el momento.

Abstract: This article evaluates the COVID-19 pandemic impacts on the Family Health Strategy (FHS) team’s work routines across a range of northeast Brazilian cities as perceived by community health workers (CHW). Data on COVID-19, CHW activities, and FHS teams were collected in 2021 by a structured questionnaire. A total of 1,935 CHWs from four state capitals (Fortaleza - Ceará State, João Pessoa - Paraíba State, Recife - Pernambuco State, Teresina - Piauí State) and four hinterland cities (Crato, Juazeiro do Norte, Barbalha, Sobral - Ceará State) participated in the study. Most CHWs were women (82.42%), with mean age 46.25±8.54 years. Many (39.92%) were infected with COVID-19, of which 70.78% believed they were infected in the workplace. A total of 77.82% defined their role as frontline in the fight against COVID-19, 16.07% reported receiving training for COVID-19, and 13.74% had access to sufficient protective equipment. Most (90.27%) believed their work routines were modified by the pandemic, either strengthening (41.46%) or weakening (44.41%) the team spirit. Home visits (60.55%), health promotion actions in schools (75.66%) and in specific community groups (93.96%), and other on-site community services (66.01%) showed a reduction in frequency. The sampled cities revealed a significant heterogeneity regarding responses to the COVID-19 pandemic, possibly associated with a lack of coordination by the Federal Government. Regardless of context, the pandemic led to a reconfiguration of local health systems, workflows, and primary care protocols for FHS teams. The importance of the Brazilian Unified National Health System (SUS) and its potential for reorganization during crisis should be acknowledged while preserving the headway made thus far.

https://doi.org/10.1590/0102-311xen007223

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