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ABSTRACT Wild birds have great prominence in the transmission of diseases to humans, mainly due to their ease of access to human populations, raising concerns about the potential impact of that proximity on public health. The present study reports ARV and PBV occurrence in wild birds from an environmental protection area in the Amazon biome, in Pará state, Brazil. We obtained 155 fecal specimens from 47 species of wild birds for RNA extraction, ARV and PBV detection utilizing molecular methods, nucleotide sequencing, and phylogenetic analysis. ARV prevalence was 0.6% (1/155), being positive in an individual of Myrmotherula longipennis, and PBV prevalence was 1.29% (2/155), affecting two individuals of Guira guira. The PBV strains were assigned to genogroup I based on phylogenetic analysis, and they shared a strong phylogenetic link with strains isolated from different geographic locations. The ARV strain was more closely related to strains that had previously circulated in the same region. The presence of ARV and PBV in this habitat suggests that infection cycles of these agents occur naturally in the wild ecosystem, potentially triggering transmission events between bird species and humans. This is the first study on ARV detection in wild birds in Brazil and the first report on the occurrence of PBV in wild Guira guira. Additional studies are required to determine the epidemiology, origin, evolution, and emergence of new potentially pathogenic viruses in the Amazon.

RESUMO As aves silvestres têm grande destaque na transmissão de doenças ao homem, principalmente pela facilidade de acesso à população humana, levantando preocupações sobre o potencial impacto dessa proximidade no contexto da saúde pública. O presente estudo relata a ocorrência de ARV e PBV em aves silvestres de uma área de proteção ambiental no bioma Amazônico. Obtivemos 155 espécimes fecais de 47 espécies de aves silvestres, que foram submetidos a extração de RNA, detecção de ARV e PBV por técnicas moleculares, sequenciamento nucleotídico e análise filogenética. A prevalência de infecção por ARV foi 0,6% (1/155), sendo positivo em um indivíduo de Myrmotherula longipennis, e a prevalência de PBV foi 1,29% (2/155), afetando dois insdivíduos de Guira guira. A análise filogenética agrupou as cepas de PBV no genogrupo I, mostrando intensa relação filogenética com cepas isoladas de outras regiões geográficas. A cepa de ARV esteve mais relacionada filogeneticamente a cepas previamente circulantes na mesma região. Este é o primeiro estudo sobre detecção de ARV em aves silvestres no Brasil e o primeiro relato sobre a ocorrência de PBV em Guira guira. A circulação de ARV e PBV nesse ambiente demonstra que os ciclos desses agentes estão ocorrendo de forma natural no ecossistema silvestre, o que pode desencadear possíveis eventos de transmissão entre as espécies aviárias e humanos. Estudos adicionais são necessários para determinar a epidemiologia, origem, evolução e surgimento de novos vírus potencialmente patogênicos na Amazônia.

https://doi.org/10.1590/1809-4392202300120

Characteristics and clinical outcomes of adolescents infected by SARS-CoV-2: a systematic review
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Campos, Cezenário Gonçalves

; Muniz, Luciene Aparecida

; Belo, Vinícius Silva

; Costa, Cássia Cristina

; Borges Neto, Juscelino de Souza

; Novais, Rommel Larcher Rachid

; Rabelo, Fernanda Lívia Dutra

; Martins Júnior, Charles Henrique

; Romano, Márcia Christina Caetano

; Lamounier, Joel Alves

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2022241

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Verificar as características clínicas, as comorbidades associadas e os desfechos da COVID-19 em adolescentes. Fontes de dados: Trata-se de uma revisão sistemática elaborada com base em artigos publicados entre 2020 e 2022 nas bases de dados United States National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS), Science Direct, Web of Science e Scopus. O estudo foi registrado no International Prospective Register of Systematic Reviews, n° CRD42022309108. Síntese dos dados: Foram identificados 1.188 estudos. Após a aplicação dos critérios de seleção, 13 artigos foram incluídos. A prevalência foi de 25%; os casos leves foram predominantes; e febre, tosse, cefaleia, anosmia, congestão nasal e ageusia foram frequentes. Febre e tosse foram proporcionalmente maiores em casos hospitalizados, com 81 e 68%, respectivamente. Dispneia (OR 6,3; IC95% 2,8–14,3), febre (OR 3,8; IC95% 2,0–7,4) e tosse (OR 3,4; IC95% 2,0–6,0) foram associados a casos graves. Até 28% necessitaram de cuidados intensivos e 38% de ventilação mecânica. A preexistência de comorbidade aumentou o risco de internação e óbito. Os casos graves estão associados ao risco de óbito (risco relativo — RR 4,6; IC95% 2,8–7,5). As raças/cores preta, parda e indígena e os moradores de regiões mais pobres foram grupo de risco. Conclusões: A revisão permitiu conhecer o perfil da doença e poderá favorecer a elaboração de políticas públicas, além de contribuir para a literatura atual no campo da saúde do adolescente.

ABSTRACT Objective: To verify the COVID-19 clinical characteristics, associated comorbidities, and outcomes in adolescents. Data source: This is a systematic review study based on articles published between 2020 and 2022 in the United States National Library of Medicine - PubMed (MedLine), Virtual Health Library – VHL (LILACS), Science Direct, Web of Science, and Scopus (Elsevier) databases. The study was registered in the International Prospective Register of Systematic Reviews, under No. CRD42022309108. Data synthesis: A total of 1188 studies were identified. After applying the selection criteria, 13 articles were included. Prevalence was 25%; mild cases were predominant; and fever, cough, headache, anosmia, nasal congestion, and ageusia were frequent. Fever and cough were proportionally higher in hospitalized cases: 81 and 68%, respectively. Dyspnea (odds ratio [OR] 6.3; confidence interval 95%[CI] 2.8–14.3), fever (OR 3.8; 95%CI 2.0–7.4), and cough (OR 3.4; 95%CI 2.0–6.0) were associated with severe cases. Up to 28% required intensive care and 38% required mechanical ventilation. Pre-existing comorbidities increased the risk of hospitalization and death. Severe cases were associated with the risk of death (relative risk [RR] 4.6; 95%CI 2.8–7.5). The black, mixed, and indigenous races/skin colors represented risk groups, as well as residents of poorer regions. Conclusions: The review provided a better understanding of the disease profile and may favor the development of public policies, in addition to contributing to the current literature in the field of adolescent health.

https://doi.org/10.1590/1984-0462/2024/42/2022241

Fatigue, depression, and physical activity in patients with malignant hyperthermia: a cross-sectional observational study
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Andrade, Pâmela Vieira de

; Valim, Lívia Maria

; Santos, Joilson Moura dos

; Castro, Isac de

; Amaral, José Luiz Gomes do

; Silva, Helga Cristina Almeida da

Brazilian Journal of Anesthesiology

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apr 2023, Volume 73 N. 2 Pages 132 - 137

Abstract: En | Text: En | PDF: En

Abstract Background Malignant Hyperthermia (MH) is a pharmacogenetic disorder triggered by halogenated anesthesia agents/succinylcholine and characterized by hypermetabolism crisis during anesthesia, but also by day-to-day symptoms, such as exercise intolerance, that may alert the health professional. Objective The study aimed to analyze the incidence of fatigue in MH susceptible patients and the variables that can impact perception of fatigue, such as the level of routine physical activity and depression. Methods A cross-sectional observational study was carried out with three groups - 22 patients susceptible to MH (positive in vitro muscle contracture test), 13 non-susceptible to MH (negative in vitro muscle contracture test) and 22 controls (no history of MH). Groups were assessed by a demographic/clinical questionnaire, a fatigue severity scale (intensity, specific situations, psychological consequences, rest/sleep response), and the Beck depression scale. Subgroups were re-assessed with the Baecke habitual physical exercise questionnaire (occupational physical activity, leisure physical exercise, leisure/locomotion physical activity). Results There were no significant differences among the three groups regarding fatigue intensity, fatigue related to specific situations, psychological consequences of fatigue, fatigue response to resting/sleeping, depression, number of active/sedentary participants, and the mean time and characteristics of habitual physical activity. Nevertheless, unlike the control sub-group, the physically active MH-susceptible subgroup had a higher fatigue response to resting/sleeping than the sedentary MH susceptible subgroup (respectively, 5.9 ± 1.9 vs. 3.9 ± 2, t-test unpaired, p< 0.05). Conclusion We did not detect subjective fatigue in MH susceptible patients, although we reported protracted recovery after physical activity, which may alert us to further investigation requirements.

https://doi.org/10.1016/j.bjane.2021.07.038

Leprosy prevalence spatial distribution and trend in a health region in Northeast Brazil, 2008-2017: an ecological study
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Oliveira, Rayanne Alves de

; Sousa, Paloma Maria Pereira de

; Silva, Janiel Conceição da

; Santos, Lívia Fernanda Siqueira

; Santos, Floriacy Stabnow

; Pascoal, Lívia Maia

; Costa, Ana Cristina Pereira de Jesus

; Santos, Leonardo Hunaldo dos

; Santos Neto, Marcelino

Epidemiologia e Serviços de Saúde

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2023, Volume 32 N. 2 elocation e2023522

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo Objetivo: analisar a distribuição espacial e a tendência da hanseníase em municípios de uma regional de saúde de um estado no Nordeste brasileiro. Métodos: estudo ecológico e de séries temporais, sobre a notificação compulsória dos municípios integrantes da Unidade Gestora Regional de Saúde de Imperatriz, Maranhão, Brasil, entre 2008 e 2017; foram determinadas as prevalências e a média para o período; realizou-se a análise espacial de área e os mapas foram gerados pelo aplicativo ArcGis 10.5; na análise de tendência, utilizou-se a regressão de Prais-Winsten. Resultado: foram identificados 4.029 casos da doença e as médias de prevalência variaram de 2,0 a 11,5 casos/10 mil habitantes/ano, com tendência descendente; Governador Edson Lobão apresentou a maior prevalência, 11,5 casos/10 mil hab., e Lajeado Novo a menor, 2,0 casos/10 mil hab. Conclusão: a distribuição espacial dos casos de hanseníase foi heterogênea nos municípios estudados e a tendência da prevalência, decrescente.

Resumen Objetivo: analisar la distribución espacial y la tendencia de la lepra en una región sanitaria de un estado del Nordeste brasileño. Métodos: estudio ecológico y de serie temporal, con notificación obligatoria de los municipios de la Unidad de Gestión Regional de Salud de Imperatriz-MA, entre 2008-2017. Se determinaron la prevalencia y la media del período y se realizó un análisis del espacio de área, los mapas se generaron en ArcGis 10.5. Para el análisis de tendencia se utilizaron regresiones de Prais-Winsten. Resultado: se identificaron 4.029 casos y las prevalencias promedio oscilaron entre 2,0 y 11,5 casos/10.000 habitantes-año, con tendencia al descenso. Governador Edson Lobão presentó la mayor prevalencia 11,5 casos/10.000 habitantes y Lajeado Novo la menor prevalencia 2,0 casos/10.000 habitantes. Conclusión: la distribución espacial de los casos de lepra fue heterogénea en los municipios y la tendencia de prevalencia decreciente.

Abstract Objective: to analyse the spatial distribution and trend of leprosy in municipalities of a health region in a Northeast Brazilian state. Methods: this was an ecological time-series study based on compulsory notification of leprosy cases by the municipalities covered by the Imperatriz-MA Regional Health Management Unit, between 2008 and 2017; prevalence and mean prevalence for the period were calculated; spatial analysis of the area was carried out and maps were generated using ArcGis 10.5. Prais-Winsten regression was used for trend analysis. Result: 4,029 cases of the disease were identified, and average prevalence ranged from 2.0 to 11.5 cases/10,000 inhabitants-year. The overall trend was downward. Governador Edson Lobão had the highest prevalence, 11.5 cases/10,000 inhabitants, and Lajeado Novo had the lowest prevalence, 2.0 cases/10,000 inhabitants. Conclusion: spatial distribution of leprosy cases was heterogeneous in the municipalities studied and prevalence had a falling trend.

https://doi.org/10.1590/s2237-96222023000200021

Coping strategies for chronically ill children and adolescents facing the COVID-19 pandemic
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Custódio, Lívia Lopes

; Costa, Débora Cristina Couto Oliveira

; Menezes, Cláudia Patrícia da Silva Ribeiro

; Figueiredo, Sarah Vieira

; Maia, Julyana Almeida

; Jorge, Maria Salete Bessa

; Chaves, Edna Maria Campelo

; Gomes, Ilvana Lima Verde

Revista Brasileira de Enfermagem

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2023, Volume 76 Suppl. 2 elocation e20230045

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo: comprender las experiencias y estrategias de afrontamiento de niños y adolescentes con enfermedades crónicas durante la pandemia de COVID-19. Métodos: estudio descriptivo, de enfoque cualitativo, realizado con seis niños y adolescentes en la recepción de un ambulatorio de un hospital pediátrico del estado de Ceará. La recolección de datos se realizó de abril a septiembre de 2021, mediante dibujo-cuento, analizados a la luz del criterio de Coutinho. Resultados: surgieron dos categorías temáticas: Situaciones que viven niños y adolescentes en tiempos de COVID-19; Estrategias de afrontamiento de niños y adolescentes en su proceso de enfermedad crónica durante la pandemia de COVID-19. Consideraciones finales: comprender las experiencias y estrategias de afrontamiento de niños y adolescentes con enfermedades crónicas demostró la expresión de la imaginación creativa, incorporado por componentes subjetivos, que pone de manifiesto una aproximación con la realidad percibida e interpretada en un contexto de pandemia de COVID-19.

ABSTRACT Objective: to understand the experiences and coping strategies of children and adolescents with chronic illnesses during the COVID-19 pandemic. Methods: a descriptive study, with a qualitative approach, carried out with six children and adolescents at the reception of an outpatient clinic of a pediatric hospital in the state of Ceará. Data collection took place from April to September 2021, using story-drawing, analyzed in light of Coutinho’s criteria. Results: two thematic categories emerged: Situations experienced by children and adolescents in times of COVID-19; Coping strategies for children and adolescents in their chronic illness process during the COVID-19 pandemic. Final considerations: understanding the experiences and coping strategies of children and adolescents with chronic illness demonstrated the expression of creative imagination, incorporated by subjective components, which brings to light an approximation with the reality perceived and interpreted in a context of the COVID-19 pandemic.

RESUMO Objetivo: compreender as vivências e estratégias de enfrentamento das crianças e adolescentes com doenças crônicas durante a pandemia de COVID-19. Métodos: estudo descritivo, de abordagem qualitativa, realizado com seis crianças e adolescentes em acompanhamento ambulatorial de um hospital pediátrico do estado do Ceará. A coleta de dados foi realizada de abril a setembro de 2021, utilizando-se desenho-estória, analisada à luz dos critérios de Coutinho. Resultados: emergiram duas categorias temáticas: Situações vivenciadas por crianças e adolescentes em tempos de COVID-19; Estratégias de enfrentamento de crianças e adolescentes em seu processo de adoecimento crônico durante a pandemia de COVID-19. Considerações finais: a compreensão das vivências e estratégias de enfrentamento das crianças e adolescentes com adoecimento crônico demonstrou a expressão da imaginação criadora, incorporada por componentes subjetivos, que traz à tona aproximação com a realidade percebida e interpretada em um contexto de pandemia pela COVID-19.

https://doi.org/10.1590/0034-7167-2023-0045

EFFECTS OF AROMATHERAPY ON ANXIETY SYMPTOMS IN WOMEN WITH BREAST CANCER: A SYSTEMATIC REVIEW
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Aragão, Vivianne Melo

; Lima, Magda Milleyde de Sousa

; Fernandes, Cristina da Silva

; Barros, Lívia Moreira

; Rodrigues, Andrea Bezerra

; Caetano, Joselany Áfio

Texto & Contexto - Enfermagem

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2023, Volume 32 elocation e20220132

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to assess the effect of aromatherapy on anxiety symptoms in women undergoing treatment for breast cancer. Method: a systematic review, carried out from the PEOT strategy: what are the effects of aromatherapy in reducing anxiety symptoms in women undergoing treatment for breast cancer? The research was conducted in six databases and in eight other data sources. Randomized clinical trials without date and language restrictions were included. Results: the sample consisted of seven studies. Aromatherapy was applied by inhalation (57.1%) and massage (42.8%), and was adopted alone or in conjunction with other interventions, demonstrating a reduction in anxiety symptoms in 71.4% of studies. The predominance of lavender, bergamot, frankincense and sandalwood essential oils is highlighted for their anxiolytic, relaxing, sedative, invigorating, antidepressant and muscle tension reducing effects. Conclusion: aromatherapy showed positive and significant results in reducing anxiety symptoms in women undergoing treatment for breast cancer.

RESUMEN Objetivo: evaluar el efecto de la aromaterapia sobre los síntomas de ansiedad en mujeres en tratamiento por cáncer de mama. Método: revisión sistemática, basada en la estrategia PEOT: ¿Cuáles son los efectos de la aromaterapia en la reducción de los síntomas de ansiedad en mujeres en tratamiento por cáncer de mama? La investigación se llevó a cabo en seis bases de datos y en otras ocho fuentes de datos. Se incluyeron ensayos clínicos aleatorizados, sin restricción de fecha e idioma. Resultados: la muestra estuvo compuesta por siete estudios. La aromaterapia se aplicó por inhalación (57,1%) y masaje (42,8%), habiéndose adoptado sola o en conjunto con otras intervenciones, demostrando una reducción de los síntomas de ansiedad en el 71,4% de los estudios. Destaca el predominio de los aceites esenciales de lavanda, bergamota, incienso y sándalo por sus efectos ansiolíticos, relajantes, sedantes, tonificantes, antidepresivos y reductores de la tensión muscular. Conclusión: la aromaterapia ha mostrado resultados positivos y significativos en la reducción de los síntomas de ansiedad en mujeres en tratamiento por cáncer de mama.

RESUMO Objetivo: avaliar o efeito da aromaterapia sobre os sintomas da ansiedade em mulheres sob tratamento para câncer de mama. Método: revisão sistemática, realizada a partir da estratégia PEOT: quais os efeitos da aromaterapia na redução dos sintomas da ansiedade em mulheres sob tratamento para o câncer de mama? A pesquisa foi realizada em seis bases de dados e em oito outras fontes de dados. Incluiu-se ensaios clínicos randomizados, sem restrição de data e idioma. Resultados: a amostra foi composta por sete estudos. A aromaterapia foi aplicada por inalação (57,1%) e massagem (42,8%), tendo sido adotada sozinha ou em conjunto a outras intervenções, demonstrando redução dos sintomas da ansiedade em 71,4% dos estudos. Ressalta-se o predomínio dos óleos essenciais de lavanda, bergamota, olíbano e sândalo, pelos seus efeitos ansiolíticos, relaxantes, sedativos, revigorantes, antidepressivos e redutores da tensão muscular. Conclusão: a aromaterapia apresentou resultados positivos e significativos na redução dos sintomas da ansiedade em mulheres em tratamento para câncer de mama.

https://doi.org/10.1590/1980-265x-tce-2022-0132en

Efficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care in the treatment of patients hospitalized with moderate-to-critical COVID-19: A pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors)
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Bonifácio, Lívia Pimenta

; Ramacciotti, Eduardo

; Agati, Leandro Barile

; Vilar, Fernando Crivelenti

; Silva, Anna Christina Tojal da

; Louzada Júnior, Paulo

; Fonseca, Benedito Antônio Lopes da

; Souza, Hayala Cristina Cavenague de

; Oliveira, Caroline Candida Carvalho de

; Aguiar, Valéria Cristina Resende

; Quadros, Carlos Augusto de Aguiar

; Dusilek, Cesar

; Itinose, Kengi

; Risson, Ricardo

; Ferreira, Lucas Roberto Rivabem

; Lopes, Renato Delascio

; Kallas, Esper Georges

; Bellissimo-Rodrigues, Fernando

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0565-2022

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Cases of coronavirus disease 2019 (COVID-19) requiring hospitalization continue to appear in vulnerable populations, highlighting the importance of novel treatments. The hyperinflammatory response underlies the severity of the disease, and targeting this pathway may be useful. Herein, we tested whether immunomodulation focusing on interleukin (IL)-6, IL-17, and IL-2, could improve the clinical outcomes of patients admitted with COVID-19. Methods: This multicenter, open-label, prospective, randomized controlled trial was conducted in Brazil. Sixty hospitalized patients with moderate-to-critical COVID-19 received in addition to standard of care (SOC): IL-17 inhibitor (ixekizumab 80 mg SC/week) 1 dose every 4 weeks; low-dose IL-2 (1.5 million IU per day) for 7 days or until discharge; or indirect IL-6 inhibitor (colchicine) orally (0.5 mg) every 8 hours for 3 days, followed by 4 weeks at 0.5 mg 2x/day; or SOC alone. The primary outcome was accessed in the “per protocol” population as the proportion of patients with clinical improvement, defined as a decrease greater or equal to two points on the World Health Organization’s (WHO) seven-category ordinal scale by day 28. Results: All treatments were safe, and the efficacy outcomes did not differ significantly from those of SOC. Interestingly, in the colchicine group, all participants had an improvement of greater or equal to two points on the WHO seven-category ordinal scale and no deaths or patient deterioration were observed. Conclusions: Ixekizumab, colchicine, and IL-2 were demonstrated to be safe but ineffective for COVID-19 treatment. These results must be interpreted cautiously because of the limited sample size.

https://doi.org/10.1590/0037-8682-0565-2022

Personal protective equipment simulation training is associated with lower COVID-19 infection among healthcare workers
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Couto, Thomaz Bittencourt

; Menezes, Paula Dias de Toledo Rodovalho

; Silva, Joyce Kelly Barreto

; Hashimoto, Priscilla Cerullo

; Sousa, Euma Ferreira de

; Valério, Selma Tavares

; Duim, Etienne Larissa

; Silva, Simone Cristina Azevedo

; Dutra, Lívia Almeida

; Szlejf, Claudia

einstein (São Paulo)

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2023, Volume 21 elocation eAO0300

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To describe the personal protective equipment training strategies during the beginning of the pandemic and to investigate the association between training and COVID-19 infection among healthcare workers. Methods This cross-sectional study conducted between March and May 2020 included 7,142 healthcare professionals who were eligible for both online and face-to-face simulation-based training on personal protective equipment use. Simulation training attendance was assessed by reviewing the attendance list, and the COVID-19 sick leave records recovered from the institutional RT-PCR database used to grant sick leave. The association between personal protective equipment training and COVID-19 was investigated using logistic regression, adjusted for sociodemographic and occupational characteristics. Results The mean age was 36.9 years (± 8.3), and 72.6% of participants were female. A total of 5,502 (77.0%) professionals were trained: 3,012 (54.7%) through online training, 691 (12.6%) through face-to-face training, and 1,799 (32.7%) through both strategies. During the study period, 584 (8.2%) COVID-19 cases were diagnosed among these professionals. The number of positive RT-PCR tests was 180 (11.0%) for untrained professionals, 245 (8.1%) for those trained only online, 35 (5.1%) for those trained face-to-face, and 124 (6.9%) for those trained with both strategies (p<0.001). Participants who received face-to-face training had a 0.43 lower risk of contracting COVID-19. Conclusion Personal protective equipment training decreased the odds of COVID-19 among healthcare professionals, with face-to-face simulation-based training being most effective.

https://doi.org/10.31744/einstein_journal/2023ao0300

Experience of ambulance drivers on transfer of suspected or confirmed patients for COVID-19
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Araújo, Dariane Veríssimo de

; Lima, Magda Milleyde de Sousa

; Fernandes, Cristina da Silva

; Frota, Natasha Marques

; Caetano, Joselany Áfio

; Galindo Neto, Nelson Miguel

; Barros, Lívia Moreira

Revista Gaúcha de Enfermagem

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2023, Volume 44 elocation e20210319

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To unveil the experience of ambulance drivers regarding the transfer of suspected or confirmed patients for COVID-19. Method: Exploratory study with a qualitative approach conducted in October 2021 with 18 drivers from the Northwestern Mesoregion of the State of Ceará-Brazil. The individual interviews occurred virtually, via Google Meet®, and for data processing the IRAMUTEQ® software was used. Results: Six classes were obtained: Feelings experienced during transfers; Concern about contamination of the work team and family members; Therapeutic itinerary, patients’ clinical status and increase in the number of transfers; Disinfection of ambulances between transfers of patients with suspected and/or diagnosed COVID-19; Gowning for patient transfers and Psychospiritual aspects of drivers during the pandemic. Conclusion: The experience was marked by challenges in adapting to the new routine and procedures during transfers. It was evidenced feelings of fear, insecurity, tension and anguish in the worker’s reports.

RESUMEN Objetivo: Desvelar la experiencia de los conductores de ambulancias sobre el traslado de pacientes sospechosos o confirmados a COVID-19. Método: Estudio exploratorio con enfoque cualitativo realizado en octubre de 2021 con 18 conductores de la Mesorregión Noroeste del Estado de Ceará. Las entrevistas individuales se realizaron de forma virtual, a través de Google Meet®, y para el procesamiento de los datos se utilizó el software IRAMUTEQ®. Resultados: Se obtuvieron seis clases: Sentimientos experimentados durante los traslados; Preocupación por la contaminación del equipo de trabajo y de los familiares; Itinerario terapéutico, estado clínico de los pacientes y aumento del número de traslados; Desinfección de las ambulancias entre los traslados de pacientes con sospecha y/o diagnóstico de COVID-19; Paramentación por los traslados de pacientes y Aspectos psicoespirituales de los conductores durante la pandemia. Conclusión: La experiencia estuvo marcada por los retos de adaptación a la nueva rutina y procedimientos durante los traslados. En los informes de los trabajadores se evidenciaron sentimientos de miedo, inseguridad, tensión y angustia.

RESUMO Objetivo: Desvelar a vivência dos condutores de ambulância sobre transferência de pacientes suspeitos ou confirmados para COVID-19. Método: Estudo exploratório com abordagem qualitativa realizado em outubro de 2021 com 18 condutores da Mesorregião Noroeste do Estado do Ceará-Brasil. As entrevistas individuais ocorreram de forma virtual, via Google Meet®, e, para processamento dos dados, foi utilizado o software IRAMUTEQ®. Resultados: foram obtidas seis classes: Sentimentos vivenciados durante as transferências; Preocupação com a contaminação da equipe de trabalho e dos familiares; Itinerário terapêutico, quadro clínico dos pacientes e aumento na quantidade de transferências; Desinfecção das ambulâncias entre as transferências de pacientes com suspeita e/ou diagnóstico de COVID-19; Paramentação para as transferências de pacientes e Aspectos psicoespirituais dos condutores durante a pandemia. Conclusão: A vivência foi marcada por desafios na adaptação à nova rotina e procedimentos durante as transferências. Foram evidenciados sentimentos de medo, insegurança, tensão e angústia nos relatos dos trabalhadores.

https://doi.org/10.1590/1983-1447.2023.20210319.en

10.

Leprosy prevalence spatial distribution and trend in a health region in Northeast Brazil, 2008-2017: an ecological study
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Oliveira, Rayanne Alves de

; Sousa, Paloma Maria Pereira de

; Silva, Janiel Conceição da

; Santos, Lívia Fernanda Siqueira

; Santos, Floriacy Stabnow

; Pascoal, Lívia Maia

; Costa, Ana Cristina Pereira de Jesus

; Santos, Leonardo Hunaldo dos

; Santos Neto, Marcelino

Epidemiologia e Serviços de Saúde

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2023, Volume 32 N. 2 elocation e2023522

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/s2237-96222023000200021

11.

Patient safety in hemodialysis clinics: perception of the nursing team
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Lima, Magda Milleyde de Sousa

; Rocha, Francisca Geisa Silvestre

; Fernandes, Cristina da Silva

; Barros, Lívia Moreira

; Galindo Neto, Nelson Miguel

; Caetano, Joselany Áfio

Revista Gaúcha de Enfermagem

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2023, Volume 44 elocation e20230022

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To analyze the perception of the nursing team regarding patient safety in hemodialysis clinics. Method: Descriptive-exploratory study with a qualitative approach, conducted with 37 professionals from the nursing team of five hemodialysis clinics, located in the cities of Sobral and Fortaleza, in Ceará, Brazil. Data were collected from October to December 2021, through semi-structured interviews recorded and analyzed by Descending Hierarchical Classification. Results: Four classes emerged: operation of hemodialysis clinics; role of companions and patients in their safety in hemodialysis clinics; role of the nursing team in the safe care of patients undergoing hemodialysis; international patient safety goals in hemodialysis clinics. Conclusion: The participants recognize the existence of shortcomings in international patient safety goals, mainly errors in patient identification and medication administration.

RESUMEN Objetivo: Analizar la percepción del equipo de enfermería sobre la seguridad del paciente en clínicas de hemodiálisis. Método: Estudio descriptivo-exploratorio con abordaje cualitativo, realizado con 37 profesionales del equipo de enfermería de cinco clínicas de hemodiálisis, ubicadas en las ciudades de Sobral y Fortaleza, en Ceará, Brasil. Los datos fueron recolectados de octubre a diciembre de 2021, a través de entrevistas semiestructuradas grabadas y analizadas por Clasificación Jerárquica Descendente. Resultados: Surgieron cuatro clases: operación de clínicas de hemodiálisis; papel del acompañante y del paciente en su seguridad en las clínicas de hemodiálisis; actuación del equipo de enfermería en el cuidado seguro de los pacientes en hemodiálisis; objetivos internacionales para la seguridad del paciente en las clínicas de hemodiálisis. Conclusión: Los participantes reconocen la existencia de fallas en las metas internacionales de seguridad del paciente, principalmente la ocurrencia de errores en la identificación de pacientes y administración de medicamentos.

RESUMO Objetivo: Analisar a percepção da equipe de enfermagem sobre a segurança do paciente em clínicas de hemodiálise. Método: Estudo descritivo-exploratório com abordagem qualitativa, realizado com 37 profissionais da equipe de enfermagem de cinco clínicas de hemodiálise, localizadas nos municípios de Sobral e Fortaleza, no Ceará, Brasil. Os dados foram coletados no período de outubro a dezembro de 2021, por meio de entrevistas semiestruturadas gravadas e analisados por Classificação Hierárquica Descendente. Resultados: Emergiram quatro classes: funcionamento das clínicas de hemodiálise; papel do acompanhante e do paciente na sua segurança em clínicas de hemodiálise; atuação da equipe de enfermagem no cuidado seguro do paciente em tratamento hemodialítico; metas internacionais de segurança do paciente nas clínicas de hemodiálise. Conclusão: Os participantes reconhecem a existência de falhas nas metas internacionais de segurança do paciente, principalmente a ocorrência de erros na identificação dos pacientes e administração de medicamentos.

https://doi.org/10.1590/1983-1447.2023.20230022.en

12.

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 N. 4 elocation e20230051

Abstract: En | Text: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists.

https://doi.org/10.1590/1806-9665-rbent-2023-0051

13.

Gentianaceae da Serra do Lenheiro, Estado de Minas Gerais, Brasil
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Costa, Maria Tereza Rodrigues

; Silva, Larissa Cristina Castro da

; Alves, Lívia Lara

; Guimarães, Elsie Franklin

Hoehnea

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2023, Volume 50 elocation e572022

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT (Gentianaceae Juss. from Serra do Lenheiro, Minas Gerais State, Brazil). We present a taxonomic treatment for the Gentianaceae from Serra do Lenheiro, Minas Gerais State, Brazil. Five genera and eight species were recognized. Identification key, morphological descriptions, photos and comments on the geographic distribution, ecology and taxonomy of the species are provided.

RESUMO (Gentianaceae Juss. da Serra do Lenheiro, Estado de Minas Gerais, Brasil). Apresentamos um tratamento taxonômico para Gentianaceae da Serra do Lenheiro, Minas Gerais, Brasil. Cinco gêneros e oito espécies foram registrados. Chave de identificação, descrições morfológicas, fotos e comentários sobre a distribuição geográfica, ecologia e taxonomia das espécies são fornecidos.

https://doi.org/10.1590/2236-8906e572022

14.

Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation
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SOARES, Gutemberg Lopes

; HILGENBERG, Lívia Christine Ribeiro

; BATISTA, Giovana Reis

; SOUZA, Matheus Kleber de Jesus

; FERREIRA, Renata Cristina Mendes

; SILVA, Irismara Sousa

; MACHADO, Tallita Marques

; PINHEIRO, Carlos Cleomir de Souza

; GUILHON-SIMPLICIO, Fernanda

; KLEIN, Andre

; PEREZ, Andrea de Castro

; LIMA, Emerson Silva

; MOURA, Clarice de Carvalho Veloso

Acta Amazonica

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sep 2022, Volume 52 N. 3 Pages 245 - 253

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O óleo de Caryocar villosum é usado na medicina popular amazônica para tratar dores e condições inflamatórias. Assim, avaliamos as propriedades antiinflamatórias e antinociceptivas do extrato etanólico obtido das cascas dos frutos desta espécie. Os testes de contorções induzidas por ácido acético, hiperalgesia mecânica induzida por carragenina, formalina, edema de pata induzido por carragenina e peritonite induzida por carragenina foram usados em camundongos. O extrato etanólico de C. villosum obtido das cascas dos frutos inibiu significativamente o número de contorções abdominais, a hiperalgesia mecânica e o tempo de lambida da pata na segunda fase do teste de formalina. Na dose de 300 mg kg-1, o extrato também reduziu significativamente o volume de edema formado na fase tardia e reduziu o recrutamento de leucócitos e neutrófilos na cavidade peritoneal, bem como os níveis de quimiocina CXCL1. Sugere-se que o extrato atenua o recrutamento de leucócitos por meio da inibição da ativação de CXCL1. A atividade antinociceptiva periférica ocorre por meio da modulação da via opioide pois o pré-tratamento com o extrato etanólico de C. villosum reverteu a antinocicepção induzida pela naltrexona.

ABSTRACT The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory and antinociceptive properties of the ethanolic extract obtained from the fruit peels of this species. The acetic acid-induced writhing, carrageenan-induced mechanical hyperalgesia, formalin, carrageenan-induced paw edema and carrageenan-induced peritonitis tests were used on mice. The C. villosum ethanolic extract significantly inhibited the number of abdominal writhes, mechanical hyperalgesia and paw licking time in the second phase of the formalin test. At a dose of 300 mg kg-1, the extract also significantly reduced the volume of edema formed in the late phase and reduced the recruitment of leukocytes and neutrophils in the peritoneal cavity, as well as CXCL1 chemokine levels. It is suggested that the extract attenuates the leukocyte recruitment by inhibiting the CXCL1 activation. The peripheral antinociceptive activity occured through opioid pathway modulation because pretreatment with C. villosum ethanolic extract reversed the naltrexone-induced antinociception.

https://doi.org/10.1590/1809-4392202200552

15.

GVHD treatment with extracorporeal photopheresis in Brazil: a national survey
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Fatobene, Giancarlo

; Cordeiro, Ana

; Mariano, Livia

; Silva, Marcia

; Bouzas, Luis

; Hamerschlak, Nelson

; Macedo, Maria Cristina

; Petta, Alessandra

; Funke, Vaneuza

; Novis, Yana

; Flowers, Mary E

; Rocha, Vanderson

Hematology, Transfusion and Cell Therapy

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sep 2022, Volume 44 N. 3 Pages 450 - 452

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.htct.2021.11.018

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