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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

LONG-TERM TREND OF NITROGEN AND PHOSPHORUS TRANSPORT IN 12 TROPICAL COASTAL WATERSHEDS IN NORTHEAST BRAZIL
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Noriega, Carlos

; Araujo, Moacyr

; Varona, Humberto L.

; Costa, Mauricio

; Calzada, Amilcar E.

; Medeiros, Carmen

; Silva, Andrea Xavier

; Portela, Livia P.

; Bezerra, Daniella S.

; Jeronimo, Rivaldo

; Barros, Paulo P.

; Araujo, Julia

; Rollnic, Marcelo

Química Nova

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2023, Volume 46 N. 6 Pages 616 - 626

Abstract: En | Text: En | PDF: En

Multiple environmental problems are caused by the accumulation of nitrogen (N) and phosphorus (P) in river water on its way to the ocean. The objective of this work was to determine the N and P loads in 12 hydrographic basins that flow into estuaries along the northeastern coast of Brazil using established methods. Additionally, natural and anthropogenic loads trends in the hydrographic basins of 12 tropical rivers in northeastern Brazil over 27 years (1990-2016) were evaluated. The results indicated an annual average increase of +1.1% in population density, while precipitation showed no significant trend. The anthropogenic loads were 21 and 112 times higher than natural inputs for N and P, respectively. Anthropogenic sources accounted for ~ 96% of all contributions. The positive trends of these loads (mainly wastewater) represented an annual average increase of 1.1% for N and 1.2% for P, for all river basins included in this study. These percentages represent average annual loads of 251 t N yr-1 and 54.8 t P yr-1. The time series of N and P in the study region showed trends that point to a constant increase, implying a greater contribution of these loads to the adjacent coastal region year after year.

https://doi.org/10.21577/0100-4042.20230058

Diversidad específica y taxonómica de la ictiofauna del Río Amacuzac, Morelos, México
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Cordero-Martínez, Gabriel

; Mercado-Silva, Norman

; García-de-Jesús, Sandra

; Arce, Elsah

; Ramírez-Ponce, Andrés

; Mejía-Mojica, Humberto

Revista de Biología Tropical

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dec 2022, Volume 70 N. 1 Pages 290 - 306

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: La diversidad de una comunidad biológica es el resultado de procesos ecológicos e históricos, los cuales, analizados en conjunto, producen una mejor comprensión de las causas que la generan. Objetivo: Actualizamos y analizamos la diversidad específica y taxonómica de la ictiofauna del río Amacuzac, México. Métodos: Durante cinco temporadas de muestreo (2019-2020), recolectamos peces de diez sitios en el río y aplicamos un análisis de conglomerados a las variables del hábitat. Resultados: Recolectamos 7 638 individuos, siete de especies nativas y nueve no nativas, incluyendo Copadichromis borleyi, un nuevo registro para el Amacuzac. La riqueza por sitio osciló entre ocho y 13 especies. Las variables del hábitat definieron cuatro grupos. Las especies más abundantes fueron: Poeciliopsis gracilis, Poecilia maylandi y Amatitlania nigrofasciata. Las especies menos abundantes fueron: Pterygoplichtys pardalis, Ilyodon whitei, Copadichromis borleyi e Ictalurus punctatus. Las especies más relevantes fueron: A. nigrofasciata, Amphilophus istlanus, Andinoacara rivulatus, Notropis boucardi, Oreochormis sp., P. maylandi, P. gracilis y Thorichthys maculipinis. Las especies más restringidas fueron: Atherinella balsana, C. borleyi e I. punctatus. Conclusiones: Las especies en peligro de extinción, A. istlanus y N. boucardi, aun prevalecen en el río. Además, se muestra un aumento en el número de especies no nativas. Analizar la diversidad desde dos perspectivas, aporta una visión más completa de los cambios que se dan en el Río Amacuzac como consecuencia del establecimiento de especies, información que es importante para futuras estrategias de conservación.

Abstract Introduction: The diversity of a biological community is the result of ecological and historical processes, which, when analyzed jointly, produce a better understanding of the causes that generate it. Objective: We update and analyze the specific and taxonomic diversity of the ichthyofauna of the Amacuzac River, Mexico. Methods: During five sampling seasons (2019-2020) we collected fishes from ten sites in the river and applied a cluster analysis to habitat variables. Results: We collected 7 638 individuals; seven were native species and nine were non-native, including Copadichromis borleyi, a new record for the Amacuzac. Richness per site ranged from eight to 13 species. Habitat variables defined four groups. The most abundant species were Poeciliopsis gracilis, Poecilia maylandi and Amatitlania nigrofasciata. The least abundant species were: Pterygoplichtys pardalis, Ilyodon whitei, Copadichromis borleyi and Ictalurus punctatus. The most prevalent species were: A. nigrofasciata, Amphilophus istlanus, Andinoacara rivulatus, Notropis boucardi, Oreochormis sp., P. maylandi, P., gracilis and Thorichthys maculipinis. The most restricted species were: Atherinella balsana, C. borleyi and I. punctatus. Conclusions: Endangered species such as A. istlanus and N. boucardi are still prevalent in the river, but non-native species continue to increase. Analyzing the diversity from two perspectives provides a more complete view of the changes taking place in the Amacuzac River as a consequence of species establishment, information that is important for future conservation strategies.

https://doi.org/10.15517/rev.biol.trop..v70i1.48830

A 2.4 GHz Coplanar Solar Cell Patch Antenna with a Semi-Analytical Evaluation of Temperature Effects
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Cambero, Eduardo V. V.

; Silva, Vinicius S.

; Paz, Humberto P.

; Doria, Renan T.

; Casella, Ivan R. S.

; Capovilla, Carlos E.

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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mar 2022, Volume 21 N. 1 Pages 194 - 206

Abstract: En | Text: En | PDF: En

Abstract Solar cells integrated with antennas have aroused scientific interest as an attractive energy source alternative in low power devices for IoT and Wireless Sensor Network applications. Since the space for all components in the systems is scarce, different integration ideas have been proposed in this field. However, further analysis of the performance of photovoltaic modules used as structural components of antennas is still lacking. In this context, this work experimentally extracts the necessary parameters to create an equivalent circuit model of a modified solar cell used as a radiator of a 2.4 GHz coplanar patch antenna. The obtained model is then used in the numerical characterization of the Current- Voltage (I-V) curves under temperature variations. Antenna design and performance are described, and the physical modifications of a commercial solar cell used in the prototype are presented. The I-V curves were generated for temperatures ranging from 243 to 325 K. The obtained simulation results within this temperature range showed a 150 mV shift of the optimal operation point, decreasing in approximately 20 mW the supported power with the temperature rise. A predictive methodology is introduced to estimate the possible values for the fill factor, energy conversion efficiency, and current density in a modified solar cell under temperature variations, allowing a fully operational photovoltaic antenna design.

https://doi.org/10.1590/2179-10742022v21i11254187

Brazilian Psychiatric Association guidelines for the management of suicidal behavior. Part 2. Screening, intervention, and prevention
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Baldaçara, Leonardo

; Grudtner, Roberta R.

; da S. Leite, Verônica

; Porto, Deisy M.

; Robis, Kelly P.

; Fidalgo, Thiago M.

; Rocha, Gislene A.

; Diaz, Alexandre P.

; Meleiro, Alexandrina

; Correa, Humberto

; Tung, Teng C.

; Malloy-Diniz, Leandro

; Quevedo, João

; da Silva, Antônio G.

Brazilian Journal of Psychiatry

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oct 2021, Volume 43 N. 5 Pages 538 - 549

Abstract: En | Text: En | PDF: En

This article continues our presentation of the Brazilian Psychiatric Association guidelines for the management of patients with suicidal behavior, with a focus on screening, intervention, postvention, prevention, and promotion. For the development of these guidelines, we conducted a systematic review of the MEDLINE (via PubMed), Cochrane Database of Systematic Reviews, Web of Science, and SciELO databases for research published from 1997 to 2020. Systematic reviews, clinical trials, and cohort/observational studies on screening, intervention, and prevention in suicidal behavior were included. This project involved 14 Brazilian psychiatry professionals and 1 psychologist selected by the Psychiatric Emergencies Committee of the Brazilian Psychiatric Association for their experience and knowledge in psychiatry and psychiatric emergencies. Publications were evaluated according to the 2011 Oxford Center for Evidence-Based Medicine (OCEBM) Levels of Evidence Classification. Eighty-five articles were reviewed (of 5,362 initially collected and 755 abstracts on the drug approach). Forms of screening, intervention, and prevention are presented. The intervention section presents evidence for psychotherapeutic and drug interventions. For the latter, it is important to remember that each medication is effective only for specific groups and should not replace treatment protocols. We maintain our recommendation for the use of universal screening plus intervention. Although the various studies differ in terms of the populations evaluated and several proposals are presented, there is already significant evidence for certain interventions. Suicidal behavior can be analyzed by evidence-based medicine protocols. Currently, the best strategy is to combine several techniques through the Safety Plan. Nevertheless, further research on the topic is needed to elucidate some approaches with particular potential for intervention and prevention. Systematic review registry number: CRD42020206517

https://doi.org/10.1590/1516-4446-2020-1108 363 downloads

Brazilian Psychiatric Association guidelines for the management of suicidal behavior. Part 1. Risk factors, protective factors, and assessment
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Baldaçara, Leonardo

; Rocha, Gislene A.

; Leite, Verônica da S.

; Porto, Deisy M.

; Grudtner, Roberta R.

; Diaz, Alexandre P.

; Meleiro, Alexandrina

; Correa, Humberto

; Tung, Teng C.

; Quevedo, João

; da Silva, Antônio G.

Brazilian Journal of Psychiatry

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oct 2021, Volume 43 N. 5 Pages 525 - 537

Abstract: En | Text: En | PDF: En

Suicide is a global public health problem that causes the loss of more than 800,000 lives each year, principally among young people. In Brazil, the average mortality rate attributable to suicide is approximately 5.23 per 100,000 population. Although many guidelines have been published for the management of suicidal behavior, to date, there are no recent guidelines based on the principles of evidence-based medicine that apply to the reality of suicide in Brazil. The objective of this work is to provide key guidelines for managing patients with suicidal behavior in Brazil. This project involved 11 Brazilian psychiatry professionals selected by the Psychiatric Emergencies Committee (Comissão de Emergências Psiquiátricas) of the Brazilian Psychiatric Association for their experience and knowledge in psychiatry and psychiatric emergencies. For the development of these guidelines, 79 articles were reviewed (from 5,362 initially collected and 755 abstracts). In this review, we present definitions, risk and protective factors, assessments, and an introduction to the Safety Plan. Systematic review registry number: CRD42020206517

https://doi.org/10.1590/1516-4446-2020-0994 701 downloads

IEEE 802.11b/g Practical Assessment Using a Low-Cost Quasi-Yagi Rectenna for Indoor RF Energy Harvesting
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Silva, Vinícius S.

; Paz, Humberto P.

; Cambero, Eduardo V. V.

; Vicentini, Ricardo M.

; Martins, Ricardo Q.

; Capovilla, Carlos E.

; Casella, Ivan R. S.

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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mar 2021, Volume 20 N. 1 Pages 143 - 157

Abstract: En | Text: En | PDF: En

Abstract This article presents an experimental analysis of the use of signals transmitted by Wireless Local Area Networks (WLAN) based on the IEEE 802.11b/g standards for Radio Frequency Energy Harvesting (RFEH) applications in indoor environments employing a Quasi-Yagi Rectenna (QYR) topology. This analysis is a crucial point to distinguish the use of the IEEE 802.11b/g standards for ambient RFEH applications and contributes to the debate on the use of different types of energy available for free in modern society. For it, a dedicated setup, developed in a controlled environment to avoid any external interference, was built to carry out the programmed measurements. The results obtained indicate that IEEE 802.11b/g standards have great potential for applications in RFEH, with the IEEE 802.11b average power four times higher than IEEE 802.11g at the rectifier output.

https://doi.org/10.1590/2179-10.1590/2179-10742021v20i11052 300 downloads

Double Patch Antenna Array for Communication and Out-of-band RF Energy Harvesting
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Silva, Vinícius S.

; Paz, Humberto P.

; Cambero, Eduardo V. V.

; Pereira, Emerson T.

; Casella, Ivan R. S.

; Capovilla, Carlos E.

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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sep 2020, Volume 19 N. 3 Pages 356 - 365

Abstract: En | Text: En | PDF: En

Abstract This paper presents a patch antenna array topology for Simultaneous Wireless Information and Power Transfer (SWIPT) applications. The resulting Double Patch Antenna Array (DPA) is composed of two patch antennas operating at different frequencies and fabricated on a unique substrate. One of the patches operates at the 1.8 GHz mobile communication band and is used for wireless communication, while the other one operates at the 2.4 GHz Industrial, Scientific, and Medical (ISM) band, and is used for Radio Frequency Energy Harvesting (RFEH). The analyzes and measurements carried out have shown that the adopted topology has satisfactory performance for communication, with a gain of 1.5 dBi, and for out-of-band energy harvesting, with a Vout of 160 mV at 2.45 GHz. These results indicate this approach as a promising strategy for low-power wireless applications.

https://doi.org/10.1590/2179-10742020v19i3788 525 downloads

Primer registro de infestación de Piscinoodinium pillulare (Dinoflagellida) en juveniles de Colossoma macropomum (Characiformes: Serrasalmidae) en cultivo semi-intensivo en Loreto, Perú
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Arbildo-Ortiz, Humberto

; Alvez-Robledo, Juleysi

; Chuquipiondo Guardia, Carlos

; Silva de Souza, Amanda Karen

Revista de Investigaciones Veterinarias del Perú

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jul 2020, Volume 31 N. 3 elocation e16662

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT The aim of this study was to describe a case of Piscinoodinium pillulare infestation and mortality in juveniles of Colossoma macropomum. In March 2019, 21 juvenile specimens of a semi-intensive fish farm were collected in the Maynas area, Loreto (Peru). Parasitological analysis of the external parts of the fish was performed and the presence of P. pillulare located on the skin, fins, gills, and nostrils was observed. Furthermore, a 30% mortality was recorded (1500 out of 5000 seeded). The non-disinfection of the pond, the inadequate control in the feeding, and the proliferation of Oreochromis niloticus (tilapia) in the culture were the causes of the proliferation of P. pillulare. This is the first reported case of P. pillulare infestation in juveniles of C. macropomum grown in the Peruvian Amazon.

RESUMEN El objetivo del estudio fue describir un caso de infestación de Piscinoodinium pillulare y mortalidad en juveniles de Colossoma macropomum. En marzo de 2019, ante una creciente ocurrencia de mortalidad en los peces de un estanque de tierra, se colectaron 21 ejemplares juveniles de un cultivo en la zona de Maynas, Loreto (Perú). Se realizó el análisis parasitológico de las partes externas de los peces y se observó la presencia de P. pillulare localizados en la piel, aletas, branquias y fosas nasales. Asimismo, se registró una mortalidad de 30% (1500 de 5000 sembrados). La no desinfección del estanque, el inadecuado control en la alimentación, y la proliferación de Oreochromis niloticus (tilapia) en el cultivo fueron los causantes de la proliferación de P. pillulare. Este es el primer caso reportado de infestación de P. pillulare en juveniles de C. macropomum cultivados en la Amazonia Peruana.

https://doi.org/10.15381/rivep.v31i3.16662

10.

Extractos de los documentos de posicionamientos y recomendaciones mexicanas en enfermedades cardiovasculares y COVID-19
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Alcocer-Gamba, Marco A.

; Gutiérrez-Fajardo, Pedro

; Cabrera-Rayo, Alfredo

; Sosa-Caballero, Alejandro

; Piña-Reyna, Yigal

; Merino-Rajme, José A.

; Heredia-Delgado, José A.

; Cruz-Alvarado, Jaime E.

; Galindo-Uribe, Jaime

; Rogel-Martínez, Ulises

; González-Hermosillo, Jesús A.

; Ávila-Vanzzini, Nydia

; Sánchez-Carranza, Jesús A.

; Jímenez-Orozco, Jorge H.

; Sahagún-Sánchez, Guillermo

; Fanghänel-Salmón, Guillermo

; Albores-Figueroa, Rosenberg

; Carrillo-Esper, Raúl

; Reyes-Terán, Gustavo

; Cossio-Aranda, Jorge E.

; Borrayo-Sánchez, Gabriela

; Ríos, Manuel Odín de los

; Berni-Betancourt, Ana C.

; Cortés-Lawrenz, Jorge

; Leiva-Pons, José L.

; Ortiz-Fernández, Patricio H.

; López-Cuellar, Julio

; Araiza-Garaygordobil, Diego

; Madrid-Miller, Alejandra

; Saturno-Chiu, Guillermo

; Beltrán-Nevárez, Octavio

; Enciso-Muñoz, José M.

; García-Rincón, Andrés

; Pérez-Soriano, Patricia

; Herrera-Gomar, Magali

; Lozoya del Rosal, José J.

; Fajardo-Juárez, Armando I.

; Olmos-Temois, Sergio G.

; Rodríguez-Reyes, Humberto

; Ortiz-Galván, Fernando

; Márquez-Murillo, Manlio F.

; Celaya-Cota, Manuel de J.

; Cigarroa-López, José A.

; Magaña-Serrano, José A.

; Álvarez-Sangabriel, Amada

; Ruíz-Ruíz, Vicente

; Chávez-Mendoza, Adolfo

; Méndez-Ortíz, Arturo

; León-González, Salvador

; Guízar-Sánchez, Carlos

; Izaguirre-Ávila, Raúl

; Grimaldo-Gómez, Flavio A.

; Preciado-Anaya, Andrés

; Ruiz-Gastélum, Edith

; Fernández-Barros, Carlos L.

; Gordillo, Antonio

; Alonso-Sánchez, Jesús

; Cerón-Enríquez, Norma

; Núñez-Urquiza, Juan P.

; Silva-Torres, Jesús

; Pacheco-Beltrán, Nancy

; García-Saldivia, Marianna A.

; Pérez-Gámez, Juan C.

; Lezama-Urtecho, Carlos

; López-Uribe, Carlos

; López-Mora, Gerardo E.

; Rivera-Reyes, Romina

Archivos de cardiología de México

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2020, Volume 90 Suppl. 1 Pages 100 - 110

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The recommendations in which the Mexican Society of Cardiology (SMC) in conjunction with the National Association of Cardiologists of Mexico (ANCAM) as well as different Mexican medical associations linked to cardiology are presented, after a comprehensive and consensual review and analysis of the topics related to cardiovascular diseases in the COVID-19 pandemic. Scientific positions are analyzed and responsible recommendations on general measures are given to patients, with personal care, healthy eating, regular physical activity, actions in case of cardio-respiratory arrest, protection of the patient and health personnel as well as precise indications in the use of non-invasive cardiovascular imaging, prescription of medications, care in specific topics such as systemic arterial hypertension, heart failure, arrhythmias and acute coronary syndromes, in addition to emphasizing electrophysiology, interventionism, cardiac surgery and in cardiac rehabilitation. The main interest is to provide the medical community with a general orientation on what to do in daily practice and patients with cardiovascular diseases in the setting of this unprecedented epidemiological crisis of COVID-19.

Resumen Se presentan las recomendaciones en las cuales la Sociedad Mexicana de Cardiología (SMC) en conjunto con la Asociación Nacional de Cardiólogos de México (ANCAM), así como diferentes asociaciones médicas mexicanas vinculadas con la cardiología, después de una revisión y análisis exhaustivo y consensuado sobre los tópicos relacionados con las enfermedades cardiovasculares en la pandemia de COVID-19, se analizan posturas científicas y se dan recomendaciones responsables sobre medidas generales a los pacientes, con cuidados personales, alimentación saludable, actividad física regular, acciones en caso de paro cardiorrespiratorio, la protección del paciente y del personal de salud así como las indicaciones precisas en el uso de la imagen cardiovascular no invasiva, la prescripción de medicamentos, cuidados en tópicos específicos como en la hipertensión arterial sistémica, insuficiencia cardiaca, arritmias y síndromes coronarios agudos, además de hacer énfasis en los procedimientos de electrofisiología, intervencionismo, cirugía cardiaca y en la rehabilitación cardiaca. El interés principal es brindar a la comunidad médica una orientación general sobre el quehacer en la práctica cotidiana y pacientes con enfermedades cardiovasculares en el escenario esta crisis epidemiológica sin precedentes de COVID-19.

https://doi.org/10.24875/acm.m20000057 445 downloads

11.

Anti-tick effect and cholinesterase inhibition caused by Prosopis juliflora alkaloids: in vitro and in silico studies
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Lima, Hélimar Gonçalves de

; Santos, Francianne Oliveira

; Santos, Acidália Carine Vieira

; Silva, Gisele Dias da

; Santos, Rafaela Jesus dos

; Carneiro, Kelli de Oliveira

; Reis, Isabella Mary Alves

; Estrela, Isabela de Oliveira

; Freitas, Humberto Fonseca de

; Bahiense, Thiago Campanharo

; Pita, Samuel Silva da Rocha

; Uzeda, Rosângela Soares

; Branco, Alexsandro

; Costa, Silvia Lima

; Batatinha, Maria José Moreira

; Botura, Mariana Borges

Revista Brasileira de Parasitologia Veterinária

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2020, Volume 29 N. 2 elocation e019819

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A atividade carrapaticida in vitro do extrato metanólico (EM) e da fração de alcaloides (FA) de Prosopis juliflora foi investigada, frente ao Rhipicephalus microplus, e relacionada com a inibição da enzima acetilcolinesterase (AChE). A predição in silico das interações de alcaloides dessa fração com a AChE1 de R. microplus (RmAChE1) foi realizada por acoplamento molecular. A atividade carrapaticida foi avaliada, utilizando-se os ensaios de imersão de adultos e larvas. Maior efeito sobre parâmetros reprodutivos de teleóginas foi verificado para a FA, com valor de Concentração Efetiva 50% (CE50) (31.6 mg/mL), quatro vezes menor do que o valor do EM (121 mg/mL). A FA induziu mortalidade de larvas (Concentração Letal de 50% - CL50 = 13,8 mg/mL). A inibição da atividade da AChE de larvas do carrapato foi observada para EM e FA, sendo a FA mais ativa (Concentração Inibitória 50%- CI50 de 0,041mg/mL). As análises químicas da FA permitiram a identificação dos alcaloides prosopina (1), juliprosinina (2) e juliprosopina (3). No ensaio in silico, observou-se que esses alcaloides podem interagir com o sítio ativo da RmAChE1, principalmente por ligações de hidrogênio e interações cátion-pi. Os alcaloides de P. juliflora têm atividade carrapaticida contra R. microplus, atuando através do mecanismo anticolinesterásico.

Abstract We investigated the in vitro acaricide activity of the methanolic extract (ME) and alkaloid-rich fraction (AF) of Prosopis juliflora on Rhipicephalus microplus and correlated this effect with acetylcholinesterase (AChE) inhibition. The acaricide activity was evaluated using adult and larval immersion tests. Also, we studied the possible interaction mechanism of the major alkaloids present in this fraction via molecular docking at the active site of R. microplus AChE1 (RmAChE1). Higher reproductive inhibitory activity of the AF was recorded, with effective concentration (EC50) four times lower than that of the ME (31.6 versus 121 mg/mL). The AF caused mortality of tick larvae, with lethal concentration 50% (LC50) of 13.8 mg/mL. Both ME and AF were seen to have anticholinesterase activity on AChE of R. microplus larvae, while AF was more active with half-maximal inhibitory concentration (IC50) of 0.041 mg/mL. The LC-MS/MS analyses on the AF led to identification of three alkaloids: prosopine (1), juliprosinine (2) and juliprosopine (3). The molecular docking studies revealed that these alkaloids had interactions at the active site of the RmAChE1, mainly relating to hydrogen bonds and cation-pi interactions. We concluded that the alkaloids of P. juliflora showed acaricide activity on R. microplus and acted through an anticholinesterase mechanism.

https://doi.org/10.1590/s1984-29612020036 719 downloads

12.

Foliar mineral content of five shrub species with nutritional potential for small ruminants in semiarid regions in northeastern Mexico
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Espinoza, Miguel Chávez

; Rodríguez, Humberto González

; Silva, Israel Cantú

; Correa, Mauricio Cotera

; Castillón, Andrés Eduardo Estrada

; Barragán, Hugo Bernal

; Meza, Marco Vinicio Gómez

Ciência Rural

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2020, Volume 50 N. 10 elocation e20200202

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O presente estudo foi realizado com o intuito de determinar os teores dos minerais Ca, P, K, Mg, Cu, Fe, Mn e Zn, ao longo do ano, em cinco espécies de arbustos consumidas por pequenos ruminantes nas regiões semiáridas do nordeste do México. Amostras de folhas de espécies arbustivas; Celtis pallida, Croton suaveolens, Forestiera angustifolia, Guaiacum angustifolium e Parkinsonia aculeata foram coletadas aleatoriamente durante doze meses consecutivos, de Julho de 2018 a Junho de 2019, em dois locais, nos municípios de Linares e Los Ramones, no estado de Nuevo Leon, México. O conteúdo mineral foi analisado através de um espectrofotômetro de absorção atômica, enquanto o fósforo foi medido pelo método da colorimetria. O município de Linares apresentou o maior conteúdo de macro e microminerais. Entre as espécies, C. pallida apresentou os maiores valores de macrominerais, enquanto o teor de microminerais foi maior na P. aculeata. Ca (média = 40.0 g kg-1 MS), K (15.4 g kg-1), Mg (3.7 g kg-1), Fe (87.2 mg kg-1), Mn (35.5 mg kg-1) estavam disponíveis em quantidades adequadas, enquanto P (1.3 g kg-1 MS), Cu (6.4 mg kg-1) e Zn (17.7 mg kg-1) foram encontrados deficientes. As espécies arbustivas deste estudo podem ser consideradas uma boa fonte de Ca, K, Mg, Fe e Mn, exceto na espécie C. suaveolens. No entanto, P, Cu e Zn devem ser suplementados.

ABSTRACT: This study was conducted to determine the monthly composition of the minerals Ca, P, K, Mg, Cu, Fe, Mn and Zn in five shrub species that are consumed by small ruminants in the semi-arid regions of northeastern Mexico. Leaves samples of shrub species; Celtis pallida, Croton suaveolens, Forestiera angustifolia, Guaiacum angustifolium and Parkinsonia aculeata were randomly collected during twelve consecutive months from July 2018 to June 2019 in two sites, located in Linares and Los Ramones counties, in the state of Nuevo Leon, Mexico. Mineral content was analyzed using an atomic absorption spectrophotometer, while phosphorus was measured by the colorimetry method. The Linares county showed the highest content of macro- and micro-minerals. Among species, C. pallida showed the highest values of macro-minerals and P. aculeata content of micro-minerals was highest. Ca (total mean = 40.0 g kg-1 DM), K (15.4 g kg-1), Mg (3.7 g kg-1), Fe (87.2 mg kg-1), Mn (35.5 mg kg-1) were available in adequate quantities, while P (1.3 g kg-1 DM), Cu (6.4 mg kg-1) and Zn (17.7 mg kg-1) were found deficient. Shrub species in this study can be considered as a good source of Ca, K, Mg, Fe and Mn except in C. suaveolens. However, P, Cu and Zn must be supplemented.

https://doi.org/10.1590/0103-8478cr20200202 619 downloads

13.

Perulernaea gamitanae (Crustacea: Lerneaidae) en juveniles de Colossoma macropomum (Characiformes: Sarrasalmidae) encultivo semi-intensivo en Loreto, Perú
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Arbildo-Ortiz, Humberto

; Alvez-Robledo, Juleysi

; Silva de Souza, Amanda Karen

Revista de Investigaciones Veterinarias del Perú

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jan 2019, Volume 30 N. 1 Pages 350 - 356

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

The aim of this study was to determine the presence of the copepod Perulernaea gamitanae in juveniles of Colossoma macropomum and to relate the abundance of the parasite with the length and weight of the hosts. Thirty specimens of 29.1 ± 2.8 cm of total length and 506.3 ± 124.6 g of body weight from a semi-intensive fish farm in Maynas, Loreto (Peru) were evaluated. It was collected 120 individuals of P. gamitanae located in the buccal cavity and in the cartilages of the gills. The prevalence was 90%, the mean intensity was 4.4 parasites/infested fish, the average abundance was 4 parasites/fish, with an intensity range of 1 to 10 parasites/fish. The abundance of this copepod was related to the length and weight of the host. This is the second record of P. gamitanae in C. macropomun in fish farms in the Peruvian Amazon.

El objetivo del estudio fue determinar la presencia del parásito copépodo Perulernaea gamitanae en juveniles de Colossoma macropomum y relacionar la abundancia del pará sito con la longitud y peso de los hospederos. Se examinaron 30 especímenes de 29.1 ± 2.8 cm de longitud total y 506.3 ± 124.6 g de peso de un cultivo semi-intensivo en la zona de Maynas, Loreto (Perú). Se colectaron 120 individuos de P. gamitanae localizados en la cavidad bucal y en los cartílagos de las branquias. La prevalencia fue de 90%, la intensidad media fue de 4.4 parásitos/pez infestado y la abundancia media fue de 4 parásitos/pez con un rango de intensidad de 1 a 10 parásitos/pez. La abundancia de este copépodo está relacionada con la longitud y peso de los hospederos. Este el segundo registro de P. gamitanae en C. macropomun en cultivo en la amazonia peruana.

https://doi.org/10.15381/rivep.v30i1.14726

14.

Relaciones hídricas en arbustos nativos del noreste de México
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González Rodríguez, Humberto

; Dueñas Tijerina, Haydee Alejandra

; Cantú Silva, Israel

; Cotera Correa, Mauricio

; Ramírez Lozano, Roque Gonzalo

; López Hernández, Juan Manuel

Revista mexicana de ciencias forestales

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dec 2018, Volume 9 N. 50 Pages 121 - 139

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: The aim of the current study was to establish how the xylem water potential (Ψ) in native shrubs such as Condalia hookeri, Cordia boissieri, Prosopis laevigata and Celtis pallida is influenced by soil water content, air temperature, relative humidity, and rainfall. Ψ was estimated at 15 days intervals between February 21 and June 30, 2017 in five different plants per species at 06:00 h and 14:00 h. During the wettest period, Ψ ranged from -0.67 (C. pallida) to -0.96 MPa (C. hookeri), in contrast, at the driest period, Ψ varied from -1.52 (P. laevigata) to -2.92 MPa (C. hookeri) at 06:00 h. At 14:00 h, C. pallida and C. hookeri achieved the highest (-1.07 MPa) and lowest (-3.10 MPa) Ψ values, respectively. Ψ at 06:00 h and rainfall were significantly and positively correlated with Ψ at 14:00 h; whereas the soil water content at different depths with Ψ values at 06:00 h was weak. P. laevigata and C. pallida maintained high values in Ψ at 06:00 h and 14:00 h under water stress conditions, so these species may be considered as drought tolerant species.

Resumen: El objetivo del presente estudio fue determinar la influencia del contenido de humedad del suelo, la temperatura del aire, la humedad relativa y la precipitación sobre el potencial hídrico xilemático (Ψ) de cuatro especies arbustivas nativas (Condalia hookeri, Cordia boissieri, Prosopis laevigata y Celtis pallida) del noreste de México. Las mediciones del Ψ se realizaron a intervalos de 15 días entre febrero 21 y junio 30 de 2017, en cinco plantas de cada especie a las 06:00 h y 14:00 h. En el periodo más húmedo, el Ψ a las 06:00 h varió de -0.67 (C. pallida) a -0.96 MPa (C. hookeri); en cambio, en el periodo más seco, el Ψ a las 06:00 h fluctuó de -1.52 (P. laevigata) a -2.92 MPa (C. hookeri). En tanto, a las 14:00 h, C. pallida y C. hookeri presentaron el mayor (-1.07 MPa) y menor (-3.10 MPa) valor, para los periodos húmedos y secos respectivamente. El Ψ a las 06:00 h y la precipitación mostraron correlaciones positivas con el Ψ de las 14:00 h; mientras que el contenido de agua en el suelo a diferentes profundidades con los valores de los Ψ a las 06:00 h fue débil. Dado que P. laevigata y C. pallida mantuvieron altos valores en el Ψ a las 06:00 h y 14:00 h bajo condiciones de estrés hídrico, estas especies pueden ser consideradas como especies tolerantes a la sequía.

https://doi.org/10.29298/rmcf.v9i50.229 887 downloads

15.

Reduction of the DNA damages, Hepatoprotective Effect and Antioxidant Potential of the Coconut Water, ascorbic and Caffeic Acids in Oxidative Stress Mediated by Ethanol
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BISPO, VANDERSON S.

; DANTAS, LUCAS S.

; CHAVES FILHO, ADRIANO B.

; PINTO, ISABELLA F.D.

; SILVA, RAILMARA P. DA

; OTSUKA, FELIPE A.M.

; SANTOS, RODRIGO B.

; SANTOS, ALINE C.

; TRINDADE, DANIELLE J.

; MATOS, HUMBERTO R.

Anais da Academia Brasileira de Ciências

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jun 2017, Volume 89 N. 2 Pages 1095 - 1109

Abstract: En | Text: En | PDF: En

ABSTRACT Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLC-ESI+-MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective action of green dwarf coconut water, caffeic and ascorbic acids on the liver and serum of rats treated with ethanol. The results showed five polyphenols in the lyophilized coconut water spiked with standards: chlorogenic acid (0.18 µM), caffeic acid (1.1 µM), methyl caffeate (0.03 µM), quercetin (0.08 µM) and ferulic acid (0.02 µM) isomers. In the animals, the activity of the serum γ-glutamyltranspeptidase (γ-GT) was reduced to 1.8 I.U/L in the coconut water group, 3.6 I.U/L in the ascorbic acid group and 2.9 I.U/L in the caffeic acid groups, when compared with the ethanol group (5.1 I.U/L, p<0.05). Still in liver, the DNA analysis demonstrated a decrease of oxidized bases compared to ethanol group of 36.2% and 48.0% for pretreated and post treated coconut water group respectively, 42.5% for the caffeic acid group, and 34.5% for the ascorbic acid group. The ascorbic acid was efficient in inhibiting the thiobarbituric acid reactive substances (TBARS) in the liver by 16.5% in comparison with the ethanol group. These data indicate that the green dwarf coconut water, caffeic and ascorbic acids have antioxidant, hepatoprotective and reduced DNA damage properties, thus decreasing the oxidative stress induced by ethanol metabolism.

https://doi.org/10.1590/0001-3765201720160581 2047 downloads

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