Resumo Objetivo Avaliar o estresse laboral, a satisfação e a motivação para o trabalho de profissionais de enfermagem de bloco operatório no Brasil. Métodos Estudo do tipo open survey nacional, realizado entre os meses de agosto e dezembro de 2023. Utilizou-se Escala de Satisfação no Trabalho - EST, o questionário de Motivação para o trabalho e a Escala de Estresse no Trabalho – EET em um formulário online. Resultados Houve um total de 385 respostas, sendo 160 profissionais (41,6%) técnicos ou auxiliares de enfermagem e 225(58,4%) enfermeiros. Houve elevada parcela de profissionais com níveis de estresse entre moderado e elevado (72,98%), tendo sido significativo o resultado de maior estresse moderado a elevado nos profissionais do turno diurno (p=0,01) e sem diferença por gênero nem faixa etária. Não houve diferença estatisticamente significativa entre as variáveis para técnicos e enfermeiros, nem em função do tipo de vínculo. Ter dois ou mais empregos e trabalhar em horários diurnos está associado a maior percepção de estresse relacionado ao trabalho. Conclusão A elevada proporção de profissionais técnicos de enfermagem e enfermeiros com estresse moderado e elevado merece destaque entre os achados da pesquisa. laboral Brasil nacional 2023 Utilizouse Utilizou se EST online 38 respostas 16 41,6% 416 41 6 (41,6% 22558,4% 225584 225 58,4% 58 4 225(58,4% 72,98%, 7298 72,98% , 72 98 (72,98%) p=0,01 p001 p 0 01 (p=0,01 etária vínculo pesquisa 202 3 1 41,6 (41,6 22558 22558,4 22 584 58,4 5 225(58,4 729 72,98 7 9 (72,98% p=0,0 p00 (p=0,0 20 41, (41, 2255 22558, 2 58, 225(58, 72,9 (72,98 p=0, p0 (p=0, (41 225(58 72, (72,9 p=0 (p=0 (4 225(5 (72, p= (p= ( 225( (72 (p (7

Resumen Objetivo Evaluar el estrés laboral, la satisfacción y la motivación para trabajar de profesionales de enfermería del bloque operatorio en Brasil. Métodos Estudio tipo open survey nacional, realizado entre los meses de agosto y diciembre de 2023. Se utilizó la Escala de Satisfacción Laboral (ESL), el Cuestionario de Motivación para el Trabajo y la Escala de Estrés Laboral (EEL) en un formulario digital. Resultados Hubo un total de 385 respuestas, de las cuales 160 fueron de profesionales (41,6 %) técnicos o auxiliares de enfermería y 225 (58,4 %) enfermeros. Hubo una elevada porción de profesionales con niveles de estrés entre moderado y alto (72,98 %), donde fue significativo el resultado de más estrés de moderado a alto entre los profesionales del turno diurno (p=0,01) y sin diferencia por género ni grupo de edad. No se observó diferencia estadísticamente significativa entre las variables de técnicos y enfermeros, ni en función del tipo de vínculo. El hecho de tener dos o más empleos y trabajar en horarios diurnos se asoció a una mayor percepción de estrés relacionado con el trabajo. Conclusión La elevada proporción de profesionales técnicos de enfermería y enfermeros con estrés de moderado a alto se destaca entre los resultados del estudio. laboral Brasil nacional 2023 ESL, ESL , (ESL) EEL (EEL digital 38 respuestas 16 41,6 416 41 6 (41, % 22 58,4 584 58 4 (58, 72,98 7298 72 98 (72,9 %, p=0,01 p001 p 0 01 (p=0,01 edad vínculo trabajo estudio 202 (ESL 3 1 41, (41 2 58, 5 (58 72,9 729 7 9 (72, p=0,0 p00 (p=0,0 20 (4 (5 72, (72 p=0, p0 (p=0, ( (7 p=0 (p=0 p= (p= (p

Abstract Objective Evaluating job stress, job satisfaction and job motivation among operating room nurses in Brazil. Methods This was a national open-ended survey carried out between August and December 2023. The Work Satisfaction Scale (WSS), the Motivation for Work questionnaire and the Work Stress Scale (WSS) were used in an online form. Results There were a total of 385 responses, of which 160 professionals (41.6%) were nursing technicians or assistants and 225 (58.4%) were nurses. There was a high proportion of professionals with moderate to high levels of stress (72.98%), with a significant result of greater moderate to high stress in day shift professionals (p=0.01) and no difference by gender or age group. There was no statistically significant difference between the variables for technicians and nurses, nor according to the type of employment. Having two or more jobs and working daytime hours is associated with a higher perception of work-related stress. Conclusion The high proportion of nursing technicians and nurses with moderate and high stress deserves to be highlighted among the research findings. Brazil openended open ended 2023 WSS, WSS , (WSS form 38 responses 16 41.6% 416 41 6 (41.6% 22 58.4% 584 58 4 (58.4% 72.98%, 7298 72.98% 72 98 (72.98%) p=0.01 p001 p 0 01 (p=0.01 group employment workrelated work related findings 202 3 1 41.6 (41.6 2 58.4 5 (58.4 729 72.98 7 9 (72.98% p=0.0 p00 (p=0.0 20 41. (41. 58. (58. 72.9 (72.98 p=0. p0 (p=0. (41 (58 72. (72.9 p=0 (p=0 (4 (5 (72. p= (p= ( (72 (p (7

ABSTRACT BACKGROUND: Detraining can partially or completely reduce training-induced metabolic adaptations. However, the duration for which the rehabilitation effects persist after detraining, especially in patients with heart disease, remains unclear. OBJECTIVES: To evaluate the principle of reversibility/detraining in patients with heart disease via the 6-minute walk test (6MWT) after a period of rest. DESIGN AND SETTING: A retrospective cohort study developed at the Rehabilitation Center of the Universidade Federal do Triângulo Mineiro in Uberaba/MG, Brazil. METHODS: This clinical, retrospective longitudinal study involved 20 patients with heart disease who underwent 5 months of supervised cardiac rehabilitation (CR). The mean age of participants was 64.05 ± 9.25 years. The initial rehabilitation was followed by an interruption period and rehabilitation for another 5 months. Functional capacity was assessed using the 6MWT. RESULTS: In the specific analysis of the distance covered, values of P = 0.03 and P = 0.01 were obtained on comparing post-training (669.64 ± 58.80 meters) with post-detraining (640.82 ± 101.23 meters) and post-detraining with post-retraining (650.82 ± 96.28 meters), respectively. No significant difference was observed for the comparison between training and retraining (P = 0.83). CONCLUSION: Cardiovascular rehabilitation positively stimulates functional capacity, whereas detraining significantly reduces it. The 6MWT is effective in measuring changes in physical capacity. BACKGROUND traininginduced induced adaptations However unclear OBJECTIVES reversibilitydetraining reversibility 6minute minute 6 MWT (6MWT rest SETTING UberabaMG Uberaba MG Uberaba/MG Brazil METHODS clinical 2 CR. CR . (CR) 6405 64 05 64.0 925 9 25 9.2 years RESULTS covered 003 0 03 0.0 001 01 posttraining post 669.64 66964 669 (669.6 5880 58 80 58.8 meters postdetraining 640.82 64082 640 82 (640.8 10123 101 23 101.2 postretraining 650.82 65082 650 (650.8 9628 96 28 96.2 meters, , respectively 0.83. 083 0.83 83 0.83) CONCLUSION it (CR 64. 92 9. 00 0. 669.6 6696 66 (669. 588 8 58. 640.8 6408 (640. 1012 10 101. 650.8 6508 65 (650. 962 96. 08 0.8 669. (669 640. (640 1 650. (650 (66 (64 (65 (6 (

ABSTRACT Arbuscular mycorrhizal fungi increase water and nutrient absorption from the soil by plants. However, its benefits to plants vary depending on the inoculated species. This study aimed to determine the influence of different species of mycorrhizal fungi on the development and productivity of grain sorghum cultivars. The experiment was conducted in a greenhouse in a completely randomized design in a 2 x 5 factorial scheme, consisting of two sorghum cultivars (BRS 310 and BRS 330) and five treatments (control without inoculation and four species of arbuscular mycorrhizal fungi: Gigaspora margarita, Glomus formosanum, Acaulospora scrobiculata, and Scutellospora pellucida), with four replications. Plant height, stem diameter, leaf area, length, volume, specific surface area, root diameter, shoot dry mass, root dry mass, thousand-grain weight, grain productivity, colonization, dependence, and mycorrhizal efficiency were evaluated. The results showed that inoculation with the species S. pellucida induced higher root and shoot development of plants of the cultivar BRS 310, as well as higher productivity of sorghum grains. The cultivar BRS 330 showed higher root development when inoculated with the species G. formosanum and a higher shoot development when inoculated with the species A. scrobiculata. Mycorrhizal dependence for grain productivity was low and varied with the inoculated species of mycorrhizal fungi. The mycorrhizal efficiency for shoot dry mass was higher with the inoculation of A. scrobiculata and S. pellucida in the cultivar BRS 310 and A. scrobiculata and G. margarita in the cultivar BRS 330. However scheme 31 control pellucida, , pellucida) replications height diameter area length volume thousandgrain thousand weight colonization evaluated S grains 33 G A 3

RESUMO: O estudo foi realizado em um ovino, fêmea, de três anos de idade, da raça santa inês, procedente de uma propriedade localizada do município de Santo Antônio de Tauá, oeste do Pará. O animal acometido tinha histórico de exoftalmia no olho esquerdo, secreção nasal e dificuldade respiratória há mais de três meses. Ao exame físico o animal apresentava baixo escore corporal, apatia, assimetria facial unilateral, moderada exoftalmia unilateral esquerda, dispneia mista e exsudação nasal serossanguinolenta profusa unilateral. À necropsia, foi observada grande massa nasal, predominantemente branco-amarelada com áreas vermelho enegrecidas, de superfície irregular, finamente granular, úmida e friável. A massa invadia desde a junção mucocutânea do nariz esquerdo até as coanas, se infiltrava pelos seios nasais frontais, placa cribiforme e alcançava as meninges e a porção frontal do cérebro. À microscopia da superfície do epitélio nasal notou-se severa destruição dos cornetos e dos epitélios, evidenciada por extensas áreas de necrose com muitos debris celulares, ulceração e infecção bacteriana secundária. No sistema nervoso central (SNC) havia meningite piogranulomatosa com acentuada congestão de vasos, focos de necrose e inflamação granulomatosa. O diagnóstico de rinite granulomatosa de origem micótica associada ao fungo Conidiobolus lamprauges foi baseado nos achados da imuno-histoquímica. RESUMO ovino fêmea idade inês Tauá Pará meses corporal apatia esquerda necropsia brancoamarelada branco amarelada enegrecidas irregular granular friável coanas frontais cérebro notouse notou epitélios celulares secundária SNC (SNC vasos imunohistoquímica. imunohistoquímica imuno histoquímica. histoquímica imuno-histoquímica

ABSTRACT: The study was conducted on a 3-year-old female Santa Inês sheep from a property located in the municipality of Santo Antônio de Tauá, west of Pará. The affected animal had a history of exophthalmos in the left eye, nasal discharge, and breathing difficulty for more than three months. On physical examination, the animal had a low body score, apathy, unilateral facial asymmetry, moderate unilateral left exophthalmos, mixed dyspnea and unilateral profuse serosanguinous nasal discharge. At necropsy, a large nasal mass was observed, predominantly yellowish-white with blackish-red areas, with an irregular, finely granular, moist, and friable surface. The mass invaded from the mucocutaneous junction of the left nostril to the choanae, infiltrated the frontal sinuses, the cribiform plate, and reached the meninges and the frontal portion of the brain. Microscopy of the surface of the nasal epithelium showed severe destruction of the turbinates and epithelia, evidenced by extensive areas of necrosis with a large amount of cellular debris, ulceration, and secondary bacterial infection. In the central nervous system there was pyogranulomatous meningitis with marked vessel congestion, as well as foci of necrosis and granulomatous inflammation. Immunohistochemistry showed intense staining of numerous intralesional hyphae for antibodies against Conidiobolus lamprauges. The diagnosis of granulomatous rhinitis of mycotic origin associated with the Conidiobolus lamprauges was based on epidemiological, clinical-pathological, and immunohistochemical data. ABSTRACT 3yearold yearold 3 year old Tauá Pará eye discharge months examination score apathy asymmetry necropsy observed yellowishwhite yellowish white blackishred blackish red irregular granular moist choanae sinuses plate brain epithelia debris ulceration infection congestion inflammation epidemiological clinicalpathological, clinicalpathological clinical pathological, pathological clinical-pathological data

ABSTRACT Exposing seeds to agents that elicit tolerance to abiotic stress, such as phytohormones and organic acids, during hydration and dehydration cycles can determine their response to later stimuli, e.g. exposure to salt stress. The aim of this study was to evaluate the action of priming cycles with different eliciting agents of salt stress tolerance on seeds of the cowpea varieties Sempre Verde and Pingo de Ouro. The seeds were subjected to the following treatments: 0.0 mM NaCl (control); 100 mM NaCl (salt stress); salt stress + three seed-priming cycles (PC) in water; salt stress + PC in gibberellic acid; salt stress + PC in hydrogen peroxide; salt stress + PC in salicylic acid; salt stress + PC in ascorbic acid. The following variables were analysed: germination, growth, dry weight, salt tolerance index, total soluble sugars, total free amino acids and proline. Salt stress (100 mM NaCl) reduced germination, length and biomass accumulation in the Sempre Verde and Pingo de Ouro varieties. These showed the best response to the priming cycles with gibberellic and salicylic acids, which promoted greater germination potential, length and biomass under a salt stress of 100 mM NaCl, affording greater tolerance via osmotic regulation, especially in the Sempre Verde variety. stimuli eg e g e.g treatments 00 0 0. control (control) 10 stress) seedpriming seed (PC water acid peroxide analysed growth weight index sugars proline (10 potential regulation variety (control 1 (1 (

RESUMO: A produção de manga (Mangifera indica) está se expandindo em muitos países e seus resíduos tem o potencial de ser usado para a fabricação de dietas para peixes. Este estudo avaliou a substituição parcial de fubá de milho por farinha de manga (FM) em dietas para piava (Megaleporinus obtusidens) em termos de performance zootécnica, glicose do plasma, enzimas intestinais e análise microbiológica. Piavas (n = 160) foram distribuídas em um esquema completamente randomizado (quatro tratamentos e quatro repetições) e alimentadas por 45 dias com dietas contendo diferentes níveis de inclusão de FM (0, 33, 66 e 100%). Não houve nenhuma contaminação microbiológica (bolor, coliformes totais, Bacillus cereus e Salmonella sp.) na FM. Os fenóis totais e taninos totais foram maiores na dieta com FM (P < 0.05). Dietas com 100% de fubá de milho substituído por MM reduziu a performance de crescimento e aumento a taxa de conversão alimentar (TCA) e os níveis de glicose nos peixes (P < 0.05). De acordo com a análise de regressão de segunda ordem, o nível ideal de inclusão de FM na dieta estimado com base no ganho de peso e o TCA foi de 23,68 e 19,75%, respectivamente (P < 0.05). O aumento gradual dos níveis de FM substituindo fubá de milho na dieta reduziu a atividade das enzimas intestinais amilase, lipase e protease alcalina (P < 0.05). Em conclusão, recomendamos a substituição de 19,75-23,68% de fubá de milho por FM, que pode ser usada nas dietas de piava. RESUMO Mangifera indica (FM Megaleporinus obtusidens zootécnica plasma n 160 repetições 4 0, 0 (0 33 6 100%. 100 . 100%) bolor, bolor (bolor sp. sp P 0.05. 005 0.05 05 0.05) (TCA ordem 2368 23 68 23,6 1975 19 75 19,75% amilase conclusão 19,7523,68% 19752368 19,75 23,68% 19,75-23,68 16 ( 3 10 00 0.0 236 2 23, 197 1 7 7523 19,7523,68 1975236 19,7 19,75-23,6 0. 752 19,7523,6 197523 19, 19,75-23, 19,7523, 19752 19,75-23 19,7523 19,75-2 19,752 19,75-

ABSTRACT: Mango (Mangifera indica) production is expanding in many countries, and its discarded residues have the potential to be used in the manufacture of fish diets. This study evaluated replacing part of the corn meal (CM) with mango meal (MM) in diets for piava (Megaleporinus obtusidens) in terms of zootechnical performance, plasma glucose, and intestinal enzymes. Piavas (n = 160) were distributed in a completely randomized design (four treatments and four replications) and were fed for 45 days with diets containing different levels of MM inclusion (0, 33, 66, and 100%). There was no microbiological contamination (mold, total coliforms, Bacillus cereus, and Salmonellasp.) in MM. The MM diet had higher total phenols and total tannins (P < 0.05). Diets with 100% of the CM replaced by MM reduced the growth performance and increased the feed conversion ratio (FCR) and plasma glucose levels in piava (P < 0.05). According to the second-order regression analysis, the optimal level of MM inclusion in the diet estimated based on weight gain and FCR was 23.68 and 19.75%, respectively (P < 0.05). The gradual increase in MM levels replacing CM in the diet reduced the activity of the intestinal enzymes amylase, lipase, and alkaline protease (P < 0.05). In conclusion, we recommended replacing 19.75-23.68% of CM with MM, which can be used in piava diets. ABSTRACT Mangifera indica countries (CM (MM Megaleporinus obtusidens n 160 replications 4 0, 0 (0 33 66 100%. 100 . 100%) mold, mold (mold coliforms cereus Salmonellasp. Salmonellasp P 0.05. 005 0.05 05 0.05) (FCR secondorder second order analysis 2368 23 68 23.6 1975 19 75 19.75% amylase lipase conclusion 19.7523.68% 19752368 19.75 23.68% 19.75-23.68 16 ( 3 6 10 00 0.0 236 2 23. 197 1 7 7523 19.7523.68 1975236 19.7 19.75-23.6 0. 752 19.7523.6 197523 19. 19.75-23. 19.7523. 19752 19.75-23 19.7523 19.75-2 19.752 19.75-

RESUMO O cultivo do milho convencional em áreas de refúgio é importante para preservação da tecnologia Bt e para atender mercados específicos com maior valor agregado aos grãos. Portanto, as pesquisas voltadas ao controle químico de plantas daninhas também devem continuar direcionadas aos híbridos convencionais de milho. O objetivo foi avaliar a seletividade de herbicidas aplicados em pré e pós-emergência de um híbrido convencional de milho cultivado no bioma Cerrado do Brasil. Foram instalados dois experimentos de campo, um na safra verão e outro segunda safra. Os tratamentos foram onze herbicidas, cujas doses são apresentadas em g ha-1 de ingrediente ativo: S-metolachlor (1.680), mesotrione + atrazine (115,2 + 2.000), mesotrione + atrazine (192 + 2.000), tembotrione + atrazine (75,6 + 2.000), tembotrione + atrazine (100,8 + 2.000), nicosulfuron + atrazine (16 + 2.000), nicosulfuron + atrazine (24 + 2.000), [mesotrione + atrazine] ([120 + 1.,200]), aplicação sequencial de [mesotrione + atrazine] ([60 + 600]), atrazine (2.000), mais testemunha capinada. Independentemente do experimento, todos os herbicidas aplicados pré e pós-emergência do milho proporcionaram baixos percentuais de fitointoxicação. Em ambos os experimentos nenhum dos tratamentos causou redução no estande, confirmando a ausência de mortalidade das plantas pela aplicação de herbicidas. O tombamento/acamamento das plantas foi observado no experimento realizado de verão e não observou efeito entre tratamentos. Massa de 100 grãos e produtividade do milho não alteraram em função da aplicação de herbicidas na pré e pósemergência da cultura. Todos os tratamentos herbicidas avaliados apresentaram seletividade ao híbrido de milho convencional. Portanto pós emergência Brasil campo ha1 ha 1 ha- ativo Smetolachlor S metolachlor 1.680, 1680 1.680 , 680 (1.680) 115,2 1152 115 2 (115, 2.000, 2000 2.000 000 2.000) 192 (19 75,6 756 75 6 (75, 100,8 1008 8 (100, 16 (1 24 (2 120 ([12 1.,200, 1200 1.,200 200 1.,200]) 60 ([6 600, 600 600]) (2.000) capinada fitointoxicação estande tombamentoacamamento tombamento acamamento 10 cultura 168 1.68 68 (1.680 115, 11 (115 2.00 00 19 75, 7 (75 100, (100 ( 12 ([1 1.,20 20 1.,200] ([ 600] (2.000 1.6 (1.68 (11 2.0 0 (7 (10 1.,2 (2.00 1. (1.6 2. 1., (2.0 (1. (2.

ABSTRACT The cultivation of conventional maize in refuge areas is important for preserving Bt technology and serving specific markets with greater added value to the grains. Therefore, research aimed at chemical weed control must also continue to be directed to conventional maize hybrids. The objective was to evaluate the selectivity of herbicides applied in preand post-emergence of a conventional maize hybrid cultivated in the Cerrado biome of Brazil. Two field experiments were set up, one in summer and the other in second season. The treatments were composed of eleven herbicide treatments, whose doses are presented in g ha-1 of active ingredient: S-metolachlor (1,440), S-metolachlor (1,680), mesotrione + atrazine (115.2 + 2,000), mesotrione + atrazine (192 + 2,000), tembotrione + atrazine (75.6 + 2,000), tembotrione + atrazine (100.8 + 2,000), nicosulfuron + atrazine (16 + 2,000), nicosulfuron + atrazine (24 + 2,000), [mesotrione + atrazine] ([120 + 1,200]), sequential application of [mesotrione + atrazine] ([60 + 600]), atrazine (2,000), plus a weeded control. Regardless of the experiment, all herbicides applied preand post-emergence of maize led to low percentages of phytointoxication. In both experiments, none of the treatments caused reductions in crop stand, confirming the absence of plant mortality due to the application of herbicides. Plant tipping/lodging was seen in summer maize, with no treatment effect. Maize 100grain mass and yield did not change as a result of the application of herbicides in preand post-emergence of the crop. All herbicide treatments evaluated showed selectivity for the conventional maize hybrid. grains Therefore hybrids postemergence post emergence Brazil up season ha1 ha 1 ha- ingredient Smetolachlor S metolachlor 1,440, 1440 1,440 , 440 (1,440) 1,680, 1680 1,680 680 (1,680) 115.2 1152 115 2 (115. 2,000, 2000 2,000 000 2,000) 192 (19 75.6 756 75 6 (75. 100.8 1008 100 8 (100. 16 (1 24 (2 120 ([12 1,200, 1200 1,200 200 1,200]) 60 ([6 600, 600 600]) (2,000) experiment phytointoxication stand tippinglodging tipping lodging effect grain 144 1,44 44 (1,440 168 1,68 68 (1,680 115. 11 (115 2,00 00 19 75. 7 (75 100. 10 (100 ( 12 ([1 1,20 20 1,200] ([ 600] (2,000 14 1,4 4 (1,44 1,6 (1,68 (11 2,0 0 (7 (10 1,2 (2,00 1, (1,4 (1,6 2, (2,0 (1, (2,

Resumo Este estudo teve como objetivo estimar a emissão e captura de CO2 devido ao processo de carbonatação de argamassas mistas, substituindo agregado natural (AN) por agregado reciclado (AR) e teores de cal para produzir material final menos emissivo. As argamassas foram submetidas à carbonatação natural em três ambientes. A profundidade de carbonatação foi avaliada aos até 119 dias de exposição ao tempo com presença de CO2, e a análise termogravimétrica determinou o teor de carbono absorvido. A avaliação dos cenários considerou diferentes profundidades para o potencial absorção de CO2. Verificou-se que quanto maior o teor de cal, maiores as emissões e captura de carbono. Contudo, a quantidade de CO2 capturada (25,41 KgCO2/m³) não neutraliza a sua emissão proveniente da produção de matérias-primas. Substituindo o AN pelo AR, as argamassas reduziram as emissões associadas à produção, em aproximadamente 8,15%. A simulação dos cenários comprovou que o controle construtivo é essencial, pois em espessuras inferiores a 20 mm a fixação máxima de carbono é alcançada antes da aplicação de revestimento. As argamassas com agregados reciclados são menos emissivas, o que é essencial na seleção de materiais de construção mais sustentáveis. CO mistas (AN AR (AR emissivo ambientes 11 absorvido Verificouse Verificou se Contudo 25,41 2541 25 41 (25,4 KgCO2/m³ KgCO2m³ KgCOm KgCO2 m³ KgCO m matériasprimas. matériasprimas matérias primas. primas matérias-primas 815 8 15 8,15% 2 revestimento emissivas sustentáveis 1 25,4 254 4 (25, KgCO2/m KgCO2m 81 8,15 25, (25 8,1 (2 8, (

Abstract This study aimed to estimate CO2 emission and uptake due to the mixed rendering mortars carbonation process, replacing natural aggregate (NA) with recycled aggregate (RA) and lime contents to produce less emissive final material. Mortars were subjected to natural carbonation in three environments. Carbonation depth was evaluated until 119 days of CO2 environmental exposure, and thermogravimetric analysis determined absorbed carbon content. The scenario evaluation considered different depths for the potential CO2 uptake. It was found that the higher the lime content, the higher the carbon emissions and capture. However, the CO2 captured amount (25.41 KgCO2/m³) does not balance its emission from raw materials production. Replacing NA for RA, the mortars reduced emissions associated with production by approximately 8.15%. The scenario simulation proved that constructive control is essential for rendering mortar depths less than 20 mm, the maximum carbon fixation is reached before rendering. Mortars with recycled aggregate are less emissive, which is essential in selecting more sustainable building materials. CO process (NA RA (RA material environments 11 exposure content capture However 25.41 2541 25 41 (25.4 KgCO2/m³ KgCO2m³ KgCOm KgCO2 m³ KgCO m 815 8 15 8.15% 2 mm 1 25.4 254 4 (25. KgCO2/m KgCO2m 81 8.15 25. (25 8.1 (2 8. (

ABSTRACT Introduction: The ureteral access sheath (UAS) is a medical device that enables repeated entrance into the ureter and collecting system during retrograde intrarenal surgery (RIRS). Its impact on stone-free rates, ureteral injuries, operative time, and postoperative complications remains controversial. Therefore, we performed a systematic review and meta-analysis comparing RIRS with versus without UAS for urolithiasis management. Purpose: To compare outcomes from retrograde intrarenal surgery (RIRS) for stone extraction with or without ureteral access sheath (UAS); evaluating stone-free rate (SFR), ureteral injuries, operative time, and postoperative complications. Materials and Methods: We systematically searched PubMed, Embase, and Cochrane Library in June 2024 for randomized controlled trials (RCTs) evaluating the efficacy and safety outcomes of UAS use in RIRS for urolithiasis treatment. Articles published between 2014 and 2024 were included. Pooled risk ratios (RRs) and mean differences (MDs) were calculated for binary and continuous outcomes, respectively. Results: Five RCTs comprising 466 procedures were included. Of these, 246 (52.7%) utilized UAS. The follow-up ranged from 1 week to 1 month. UAS reduced the incidence of postoperative fever (RR 0.49; 95% confidence interval [CI] 0.29–0.84; p=0.009), and postoperative infection (RR 0.50; 95% CI 0.30–0.83; p=0.008). There were no significant differences between groups in terms of SFR (RR 1.05; 95% CI 0.99–1.11; p=0.10), ureteral injuries (RR 1.29; 95% CI 0.95–1.75; p=0.11), operative time (MD 3.56 minutes; 95% CI −4.15 to 11.27 minutes; p=0.36), or length of stay (MD 0.32 days; 95% CI −0.42 to 1.07 days; p=0.40). Conclusion: UAS leads to a lower rate of post-operative fever and infection. However, UAS did not significantly reduce or increase the SFR or the rate of ureteral injuries during RIRS for patients with urolithiasis. The use of UAS should be considered to decrease the risk of infectious complications, particularly in those who may be at higher risk for such complications. Introduction (UAS RIRS. . stonefree free rates controversial Therefore metaanalysis meta analysis management Purpose (RIRS SFR, , (SFR) Methods PubMed Embase 202 (RCTs treatment 201 included RRs (RRs MDs (MDs respectively Results 46 these 24 52.7% 527 52 7 (52.7% followup follow up month RR 0.49 049 0 49 95 [CI 0.29–0.84 029084 29 84 p=0.009, p0009 p p=0.009 009 p=0.009) 0.50 050 50 0.30–0.83 030083 30 83 p=0.008. p0008 p=0.008 008 p=0.008) 1.05 105 05 0.99–1.11 099111 99 11 p=0.10, p010 p=0.10 10 p=0.10) 1.29 129 0.95–1.75 095175 75 p=0.11, p011 p=0.11 p=0.11) MD 356 3 56 3.5 minutes 415 4 15 −4.1 1127 27 11.2 p=0.36, p036 p=0.36 36 p=0.36) 032 32 0.3 days 042 42 −0.4 107 07 1.0 p=0.40. p040 p=0.40 40 p=0.40) Conclusion post However (SFR 20 2 52.7 5 (52.7 0.4 04 9 0.29–0.8 02908 8 p000 p=0.00 00 0.5 0.30–0.8 03008 0.99–1.1 09911 p01 p=0.1 1.2 12 0.95–1.7 09517 35 3. 41 −4. 112 11. p03 p=0.3 03 0. −0. 1. p04 p=0.4 52. (52. 0.29–0. 0290 p00 p=0.0 0.30–0. 0300 0.99–1. 0991 p0 p=0. 0.95–1. 0951 −4 −0 (52 0.29–0 029 0.30–0 030 0.99–1 099 p=0 0.95–1 095 − (5 0.29– 02 0.30– 0.99– 09 p= 0.95– ( 0.29 0.30 0.99 0.95 0.2 0.9

RESUMO O processo de secagem é de suma importância para a manutenção da qualidade das sementes, onde a temperatura de condução deste processo exerce influência direta sobre a germinação e vigor, sobretudo para as espécies olerícolas que são colhidas com alto teor de água. O objetivo desta pesquisa foi determinar e modelar as curvas de secagem de sementes de jiló (cultivar Tinguá-verde-claro) nas temperaturas de 35, 38, 41 e 44 ºC, bem como avaliar a qualidade fisiológica das sementes após a secagem. Foi utilizado o delineamento inteiramente casualizado, sendo quatro temperaturas de secagem (35, 38, 41 e 44 ºC) com quatro repetições. Nove modelos matemáticos foram ajustados por meio de análise de regressão não linear pelo método de Gauss-Newton, e o grau de ajuste foi avaliado com base na magnitude do coeficiente de determinação (R2), teste qui-quadrado (χ2), erro médio relativo (P) e erro médio estimado (SE). A qualidade das sementes foi avaliada pelo teste de germinação (G), condutividade elétrica (CE) e envelhecimento acelerado (EA). O modelo ‘Midilli Modificado’ é o que melhor representa as curvas de secagem das sementes de jiló nas temperaturas estudadas. Sementes com maior germinação e vigor, ou seja, com menores valores de CE e maiores taxas de germinação após EA, são alcançadas através da secagem a 35 e 38 ºC. vigor água cultivar Tinguáverdeclaro Tinguá verde claro Tinguá-verde-claro 4 ºC casualizado (35 repetições GaussNewton, GaussNewton Gauss Newton, Newton Gauss-Newton R2, R2 R , (R2) quiquadrado qui quadrado χ2, χ2 χ (χ2) P (P SE. SE . (SE) G, G (G) (CE EA. EA (EA) Midilli Modificado estudadas seja 3 (3 (R2 (χ2 (SE (G (EA ( (R (χ

ABSTRACT The drying process is paramount for maintaining seed quality, where the temperature during this process directly influences germination and vigor, especially for vegetable species harvested with high moisture content. This research aimed to determine and model the drying curves of S. aethiopicum (cultivar Tinguá-verde-claro) seeds at temperatures of 35, 38, 41, and 44 ºC, as well as to evaluate the physiological quality of the seeds after drying. A completely randomized design was used, with four drying temperatures (35, 38, 41, and 44 ºC) and four replicates. Nine mathematical models were fitted using the non-linear regression analysis by the Gauss-Newton method, and the goodness of fit was assessed based on the magnitude of the coefficient of determination (R2), chi-square test (χ2), relative mean error (P), and estimated mean error (SE). Seed quality was evaluated by germination test (G), electrical conductivity (EC), and accelerated aging (AA). The Modified Midilli model best represents the drying curves of S. aethiopicum seeds at the studied temperatures. Seeds with higher germination and vigor, meaning lower electrical conductivity values and higher germination rates after accelerated aging, are achieved through drying at 35 and 38 ºC. vigor content S cultivar Tinguáverdeclaro Tinguá verde claro Tinguá-verde-claro 41 4 ºC used (35 replicates nonlinear non linear GaussNewton Gauss Newton method R2, R2 R , (R2) chisquare chi square χ2, χ2 χ (χ2) P, P (P) SE. SE . (SE) G, G (G) EC, EC (EC) AA. AA (AA) 3 (3 (R2 (χ2 (P (SE (G (EC (AA ( (R (χ

RESUMO A avaliação nutricional em mangueiras baseada em métodos diagnósticos que consideram o equilíbrio nutricional tem sido recomendada. Os objetivos deste estudo foram: estabelecer faixas nutricionais ótimas por métodos diagnósticos e compará-las entre si; identificar o método diagnóstico mais eficiente na determinação de desequilíbrios nutricionais; e selecionar os nutrientes que melhor respondem à aplicação do método diagnóstico. O estudo foi realizado em pomares comerciais de mangueira no Vale do São Francisco-PE, Brasil. Foram calculados os teores nutricionais pelos métodos Sistema Integrado de Diagnóstico e Recomendação (DRIS-Beaufils, DRIS-Jones), DRIS Modificado (M-DRIS-Beaufils; M-DRIS-Jones), Diagnose da Composicão Nutricional (CND) e Chance Matemática (ChM) e comparados entre si pelo teste qui-quadrado. A análise de componentes principais foi aplicada para selecionar o método diagnóstico mais eficiente e os nutrientes responsáveis pela maior variabilidade. Os métodos DRIS Beaufils, M-DRIS Beaufils, DRIS Jones, M-DRIS Jones, CND e ChM geraram faixas de suficiência nutricional para as cultivares avaliadas. Os diagnósticos nutricionais dos métodos DRIS-Beaufils e M-DRIS Beaufius foram semelhantes entre si e discordantes dos métodos DRIS-Jones, M-DRIS-Jones e CND que foram semelhantes. O método DRIS Beaufils atualizado por Maia mostrou-se mais consistente na avaliação nutricional de mangueiras. Os nutrientes N, P, K, Mg e S na cultivar Tommy Atkins; N, P, Mg, S, B, Mn, Zn, Mo e Cl na cultivar Kent; e N, P, K, Ca, S, B, Cu, Fe, Zn, Mo e Cl na cultivar Keitt apresentam potencial de resposta significativa à aplicação do método DRIS-Beaufils atualizado por Maia. recomendada comparálas compará las FranciscoPE, FranciscoPE Francisco PE, PE Francisco-PE Brasil DRISBeaufils, DRISBeaufils (DRIS-Beaufils DRISJones, DRISJones Jones , DRIS-Jones) MDRISBeaufils M (M-DRIS-Beaufils MDRISJones, MDRISJones M-DRIS-Jones) (CND (ChM quiquadrado. quiquadrado qui quadrado. quadrado qui-quadrado variabilidade MDRIS avaliadas DRIS-Jones mostrouse mostrou se N P K Atkins B Mn Zn Kent Ca Cu Fe

ABSTRACT Nutritional assessment of mango trees based on diagnostic methods considering nutritional balance is recommended. This study aimed to establish optimum nutritional ranges using diagnostic methods, compare them, identify the most efficient diagnostic method, and select the nutrients responding best to the application of the diagnostic method. The study was conducted in commercial mango orchards in the São Francisco Valley. Nutritional content was calculated using the diagnosis and recommendation integrated system (DRIS-Beaufils, DRIS-Jones), modified DRIS (M-DRIS-Beaufils; M-DRIS-Jones), compositional nutrient diagnosis (CND), and mathematical chance (ChM) methods and compared using the chi-square test. Principal component analysis was applied to select the most efficient diagnostic method and the nutrients responsible for the greatest variability. The DRIS-Beaufils, M-DRIS-Beaufils, DRIS-Jones, M-DRIS-Jones, CND, and ChM methods generated nutritional sufficiency ranges for the evaluated cultivars. The nutritional diagnoses of the DRIS-Beaufils and M-DRIS-Beaufils methods were similar and discordant with those of DRIS-Jones, M-DRIS-Jones, and CND. The DRIS-Beaufils method, updated by Maia, proved to be more consistent for the nutritional assessment of mango trees. The nutrients N, P, K, Mg, and S in the Tommy Atkins cultivar; N, P, Mg, S, B, Mn, Zn, Mo, and Cl in the Kent cultivar; and N, P, K, Ca, S, B, Cu, Fe, Zn, Mo, and Cl in the Keitt cultivar showed significant responses to the application of the DRIS-Beaufils method updated by Maia. recommended them Valley DRISBeaufils, DRISBeaufils Beaufils, Beaufils (DRIS-Beaufils DRISJones, DRISJones Jones , DRIS-Jones) MDRISBeaufils M (M-DRIS-Beaufils MDRISJones, MDRISJones M-DRIS-Jones) CND (CND) (ChM chisquare chi square test variability MDRISBeaufils, Jones, DRIS-Jones M-DRIS-Jones cultivars Maia N P K Mg B Mn Zn Mo Ca Cu Fe (CND

ABSTRACT Care for human well-being and health requires the consumption of healthy foods, and therefore, the “baby-leaf” gains increased space in the market as they have higher concentrations of bioactive compounds. The present study aimed to evaluate the growth and bioactive compounds of baby-leaf chicory (Cichorium intybus L.) according to the color of cultivation benches with different wavelengths. The experiment was conducted in a non-acclimatized greenhouse, covered with low density polyethylene film with an aluminized screen of 50% shading under the film and 50% shading screens on the sides. In a completely randomized design, five types of benches were evaluated without and with bright reflective colored materials: Control bench without reflective material, a bench with reflective bright white laminate, reflective bright dark red laminate, reflective bright dark blue laminate, and reflective bright yellow laminate. The bright white and yellow laminates amplified the most photosynthetically active radiation. All the laminates enhanced yield of baby-leaf chicory plants, where white, yellow, red, and dark blue enhanced the fresh matter by 102.6%, 50.2%, 60.6%, and 37.4% compared to the control, respectively. The bright dark blue laminates enhanced the bioactive compounds of baby-leaf chicory plants. The bright dark blue laminate enhanced the carotenoid production of baby-leaf chicory plants by 11.0%. The use of colored laminates was effective in the cultivation of baby-leaf chicory, both in terms of yield and quality, with significant increases in fresh matter and bioactive compounds. To provide baby-leaf chicory with higher bioactive content with antioxidant effect (carotenoids) the use of dark blue laminates is necessary; however, if the objective is greater shoot DM it will be white laminates.

RESUMO O objetivo deste estudo foi identificar as fases de plastocrono em cultivares de soja com hábito de crescimento determinado e indeterminado. Os experimentos foram conduzidos no período de 2010/2011 a 2022/2023 em quatro locais do estado do Rio Grande do Sul, Brasil, com 25 cultivares de soja com hábito de crescimento determinado (6) e indeterminado (19). Este estudo buscou dividir o plastocrono em fases durante o período de emissão de nós da soja. Em cultivares irrigadas de hábito de crescimento determinado, o plastocrono apresenta duas fases, a fase inicial de 59,7 °C dia nó-1 e a fase final de 65,7 °C dia nó-1. Em ambientes não irrigados, não há diferença entre as fases inicial e final do plastocrono. As cultivares de hábito de crescimento indeterminado com irrigação apresentam um plastocrono médio inicial e final de 64,1 °C dia nó-1, ao contrário da fase intermediária onde o plastocrono é de 58,5 °C dia nó-1. Em ambientes de sequeiro, as fases inicial e intermédia têm um valor médio de 60,6 °C dia nó-1, ao contrário da fase final com um plastocrono de 79,4 °C dia nó-1. A divisão do plastocrono em fases durante o período de emissão de nós na cultura da soja, proposta neste estudo, permite-nos melhorar o entendimento do desenvolvimento vegetativo de cultivares de soja de hábito de crescimento determinado e indeterminado e estabelecer bases ecofisiológicas para a construção de uma função cronológica. 20102011 2010 2011 2010/201 20222023 2022 2023 2022/202 Sul Brasil 2 6 (6 19. 19 . (19) 597 59 7 59, C nó1 nó 1 nó- 657 65 65, nó1. 1. irrigados 641 64 64, nó1, 1, 585 58 5 58, sequeiro 606 60 60, 794 79 4 79, permitenos permite nos cronológica 2010201 201 2010/20 2022202 202 2022/20 ( (19 201020 20 2010/2 202220 2022/2 (1 20102 2010/ 20222 2022/

ABSTRACT The aim of this study was to identify plastochron phases in soybean cultivars with determinate and indeterminate growth habits. Experiments were conducted from 2010/2011 to 2022/2023 at four locations in Rio Grande do Sul state (RS), Brazil, using 25 soybean cultivars with determinate (6) and indeterminate (19) growth habits. This study divided the plastochron into phases during the soybean node emission stage. In irrigated cultivars with a determinate growth habit, the plastochron has an early and late phase of 59.7 and 65.7 °C day node-1, respectively. In rainfed (non-irrigated) environments, there is no difference between the early and late plastochron phases. The early and late plastochrons of irrigated cultivars with an indeterminate growth habit are 64.1 °C day node-1, while the intermediate phase is 58.5 °C day node-1. In rainfed environments, the average value of the early and intermediate phases is 60.6 °C day node-1, with a late plastochron of 79.4 °C day node-1. Dividing the plastochron into phases during node emission, as proposed in this study, improves understanding of vegetative development in soybean cultivars with determinate and indeterminate growth habits and establishes ecophysiological foundations for chronological function construction. 20102011 2010 2011 2010/201 20222023 2022 2023 2022/202 RS, RS , (RS) Brazil 2 6 (6 19 (19 stage 597 59 7 59. 657 65 65. C node1, node1 1, 1 node-1 respectively nonirrigated non (non-irrigated environments 641 64 64. 585 58 5 58. node1. 1. 606 60 60. 794 79 4 79. construction 2010201 201 2010/20 2022202 202 2022/20 (RS ( (1 node- 201020 20 2010/2 202220 2022/2 20102 2010/ 20222 2022/

Abstract Primary anal cancer accounts for 1% to 3% of gastrointestinal cancers. The most common histology is squamous cell carcinoma, with an incidence of 0.5 to 2 per 100,000 people. The main risk factor is infection with the human papillomavirus, particularly subtypes 16 and 18, which represent 85% to 93% of cases. Treatment and prognosis depend on the stage of the tumor. Localized tumors can be treated with curative surgery, but locally advanced stages require a combination of chemotherapy and radiation. Advanced-stage tumors (IIIC and IV) have a poor prognosis even with chemotherapy. In recent years, immunotherapy and targeted therapies have shown promise in improving survival for patients with advanced, recurrent, or difficult-to-treat disease. We present the case of a 69-year-old woman with moderately differentiated squamous cell carcinoma (T2N1M0, stage IIIA) of the anal canal who, after treatment with chemoradiotherapy and checkpoint inhibitors and subsequent disease progression, received targeted therapy (cetuximab) and achieved complete remission with a sustained response for over 18 months. This case highlights the challenges of treating advanced anal cancer and the potential benefits of targeted therapy, particularly cetuximab, in achieving long-term responses. Further research and large-scale studies are needed to determine the role of targeted therapy and immunotherapy in the treatment of anal canal cancer.

Resumen El cáncer anal primario representa del 1% al 3% de los cánceres gastrointestinales. La histología más común es el carcinoma escamocelular, con una incidencia de 0,5 a 2 por cada 100.000 personas. El principal factor de riesgo es la infección por el virus del papiloma humano, especialmente los subtipos 16 y 18, que representan del 85% al 93% de los casos. El tratamiento y el pronóstico dependen del estadio del tumor. Los tumores localizados se pueden tratar con cirugía curativa, pero las etapas localmente avanzadas requieren una combinación de quimioterapia y radiación. Los tumores en estadio avanzado (IIIC y IV) tienen un mal pronóstico incluso con quimioterapia. En los últimos años, la inmunoterapia y las terapias dirigidas son prometedoras para mejorar la supervivencia de los pacientes con enfermedad avanzada, recurrente o difícil de tratar. Se presenta el caso de una mujer de 69 años con carcinoma escamocelular moderadamente diferenciado (T2N1M0, estadio IIIA) del canal anal que, después del tratamiento con quimiorradioterapia e inhibidores de punto de chequeo y luego de la progresión de la enfermedad, recibió tratamiento con terapia blanco (cetuximab) y logró la remisión completa de la enfermedad y una respuesta mantenida por más de 18 meses. Este caso destaca los desafíos del tratamiento del cáncer anal avanzado y los beneficios potenciales de la terapia dirigida, especialmente cetuximab, para lograr respuestas a largo plazo. Se necesitan más investigaciones y estudios a gran escala para determinar el papel de la terapia blanco y la inmunoterapia en el tratamiento del cáncer del canal anal.

Resumo Fundamento A frequência cardíaca (FC) na insuficiência cardíaca com fração de ejeção reduzida (ICFEr) e ritmo sinusal apresenta valor prognóstico. Entretanto, o método de mensuração é debatido na literatura. Objetivos Comparar em pacientes com ICFEr e ritmo sinusal a FC no Holter com três eletrocardiogramas de repouso: ECG1, ECG2 e ECG3. Metodologia Estudo transversal com 135 pacientes portadores de insuficiência cardíaca com fração de ejeção ≤ 40% e ritmo sinusal. A FC foi avaliada por ECG e Holter. Análises incluíram o coeficiente de correlação intraclasse (CCI), regressão robusta, raiz do erro quadrático médio, Bland-Altman e a área sobre a curva ROC. Adotou-se nível de significância de 0,05 e o ajuste de Bonferroni-Holm para minimizar erros tipo I. Resultados As medianas [intervalo interquartil] de idade e fração de ejeção foram de 65 anos [16] e 30% [11], respectivamente. O CCI dos 3 ECG foi de 0,922 (intervalo de confiança de 95%: 0,892; 0,942). Os coeficientes de regressão robusta para ECG1 e ECG3 foram 0,20 (intervalo de confiança de 95%: 0,12; 0,29) e 0,21 (intervalo de confiança de 95%: 0,06; 0,36). O R2 robusto foi de 0,711 (intervalo de confiança de 95%: 0,628; 0,76). Na análise de concordância de Bland-Altman, os limites de concordância foram de −17,0 (intervalo de confiança de 95%: −19,0; −15,0) e 32,0 (intervalo de confiança de 95%: 30,0; 34,0). A área sob a curva ROC foi de 0,896 (intervalo de confiança de 95%: 0,865; 0,923). Conclusão A FC do ECG mostrou alta concordância com a FC do Holter, validando seu uso clínico em pacientes com ICFEr e ritmo sinusal. Contudo, a concordância foi subótima em um terço dos pacientes com FC inferior a 70 bpm pelo ECG, devendo ser considerada a realização de Holter neste contexto. (FC (ICFEr prognóstico Entretanto literatura repouso 13 40 CCI, , (CCI) médio BlandAltman Bland Altman Adotouse Adotou se 005 0 05 0,0 BonferroniHolm Bonferroni Holm I intervalo interquartil 6 16 [16 30 11, 11 [11] respectivamente 0922 922 0,92 95% 95 0,892 0892 892 0,942. 0942 0,942 . 942 0,942) 020 20 0,2 0,12 012 12 0,29 029 29 021 21 0,06 006 06 0,36. 036 0,36 36 0,36) R 0711 711 0,71 0,628 0628 628 0,76. 076 0,76 76 0,76) BlandAltman, Altman, 170 17 −17, −19,0 190 19 −15,0 150 15 320 32 32, 30,0 300 34,0. 340 34,0 34 34,0) 0896 896 0,89 0,865 0865 865 0,923. 0923 0,923 923 0,923) Contudo 7 contexto 1 4 (CCI 00 0, [1 [11 092 92 0,9 9 089 89 094 0,94 94 02 2 0,1 01 03 0,3 071 71 0,7 0,62 062 62 07 −17 −19, −15, 30, 34, 0,8 0,86 086 86 [ 09 08 8 0,6 −1 −19 −15 −

Abstract Background Heart rate (HR) has shown prognostic value in patients with heart failure with reduced ejection fraction (HFrEF) and sinus rhythm. However, the method of measurement is debated in the literature. Objectives To compare HR on Holter with 3 resting electrocardiograms (ECG1, ECG2, and ECG3) in patients with HFrEF and sinus rhythm. Methods This was a cross-sectional study with 135 patients with heart failure with ejection fraction ≤ 40% and sinus rhythm. HR was assessed by ECG and Holter. Analyses included intraclass correlation coefficient (ICC), robust regression, root mean squared error, Bland-Altman, and area under the receiver operating characteristic (ROC) curve. A significance level of 0.05 and Bonferroni-Holm adjustment were adopted to minimize type I errors. Results The median [interquartile range] age and ejection fraction were 65 years [16] and 30% [11], respectively. The ICC of the 3 ECGs was 0.922 (95% confidence interval: 0.892; 0.942). The robust regression coefficients for ECG1 and ECG3 were 0.20 (95% confidence interval: 0.12; 0.29) and 0.21 (95% confidence interval: 0.06; 0.36). The robust R2 was 0.711 (95% confidence interval: 0.628; 0.76). In the Bland-Altman agreement analysis, the limits of agreement were −17.0 (95% confidence interval: −19.0; −15.0) and 32.0 (95% confidence interval: 30.0; 34.0). The area under the ROC curve was 0.896 (95% confidence interval: 0.865; 0.923). Conclusion The HR on ECG showed high agreement with the HR on Holter, validating its clinical use in patients with HFrEF and sinus rhythm. However, agreement was suboptimal in one third of patients with HR below 70 bpm on ECG; thus, 24-hour Holter monitoring should be considered in this context. (HR (HFrEF rhythm However literature ECG1, (ECG1 ECG2 crosssectional cross sectional 13 40 ICC, , (ICC) error BlandAltman, BlandAltman Bland Altman, Altman (ROC 005 0 05 0.0 BonferroniHolm Bonferroni Holm errors interquartile range 6 16 [16 30 11, 11 [11] respectively 0922 922 0.92 95% 95 (95 interval 0.892 0892 892 0.942. 0942 0.942 . 942 0.942) 020 20 0.2 0.12 012 12 0.29 029 29 021 21 0.06 006 06 0.36. 036 0.36 36 0.36) R 0711 711 0.71 0.628 0628 628 0.76. 076 0.76 76 0.76) analysis 170 17 −17. −19.0 190 19 −15.0 150 15 320 32 32. 30.0 300 34.0. 340 34.0 34 34.0) 0896 896 0.89 0.865 0865 865 0.923. 0923 0.923 923 0.923) 7 thus 24hour hour 24 context (ECG 1 4 (ICC 00 0. [1 [11 092 92 0.9 9 (9 089 89 094 0.94 94 02 2 0.1 01 03 0.3 071 71 0.7 0.62 062 62 07 −17 −19. −15. 30. 34. 0.8 0.86 086 86 [ 09 ( 08 8 0.6 −1 −19 −15 −