ABSTRACT Objectives: To evaluate the alternate use of flash glucose monitoring (FGM) with self-monitoring blood glucose (SMBG), in patients with type 1 diabetes (T1D). Materials and methods: Two weeks of open FGM (P2), both preceded (P1) and followed by 2 weeks (P3) of SMBG with a blinded FGM system. Mean absolute relative difference (MARD) was calculated by (|FGMi − SMBGi|) / SMBGi, where it was a paired data sample. Results: In total, 34 patients were evaluated. Time in range (TIR) did not change between P1 and P2. In 12 patients (35.3%), TIR increased from 40% at P1 to 52% at P2 (p = 0.002) and in 22 (64.7%), TIR decreased or did not change. FGM use resulted in decreased % time spent in hypoglycemia (<70 mg/dL) (6.5% vs. 5.0%; p = 0.005), increased % time spent in hyperglycemia (>180 mg/dL) (44.5% to 51%; p = 0.046) with no significant change in % TIR. The proportion of patients who reached sensor-estimated glycated hemoglobin (eA1c) < 7% decreased from 23.5% at P1 to 12.9% at P2, p = 0.028. For the whole sample, the MARD between the two methods was 15.5% (95% CI 14.5-16.6%). For normal glucose range, hyperglycemic levels and hypoglycemic levels MARD were 16.0% (95% CI 15.0-17.0%), 13.3% (95% CI 11.5-15.2%) and 23.4% [95% CI 20.5-26.3%)], respectively. Conclusion: FGM after usual SMBG decreased the % time spent in hypoglycemia concomitant with an undesired increase in % time spent in hyperglycemia. Lower accuracy of FGM regarding hypoglycemia levels could result in overcorrection of hypoglycemia.

RESUMO O objetivo deste trabalho foi avaliar a eficiência de extratores de cápsula porosa, associados a medidores de íons específicos, para determinar a disponibilidade de nutrientes em pimentão e melão cultivados em substrato. A solução de substrato foi obtida utilizando o extrator aquoso 1:1,5 (v/v) e o extrator de cápsula porosa. A condutividade elétrica (CE), o pH e a concentração dos macronutrientes na solução do substrato foram determinados por meio do método analítico. Além disso, foram determinadas as concentrações de NO ‑ e K+ nas soluções obtidas com os extratores de cápsula porosa, bem como as concentrações de N e K na folha diagnose do estado nutricional. As concentrações de NO- e K+ obtidas por extratores de cápsula porosa apresentam forte correlação (r=0,96 e 0,92, respectivamente) com as obtidas pelo método padrão, bem como correlação moderada (r=0,65) e forte (r=0,71) com as concentrações de N e K, respectivamente, na folha diagnose do estado nutricional do melão e, correlação fraca (r=0,36 e 0,26, respectivamente) na folha diagnose do estado nutricional do pimentão. A utilização de extratores de cápsula porosa para a obtenção da solução do substrato e, a determinação das concentrações de N-NO3- e K+ por medidores de íons específicos, é um método rápido para avaliar a disponibilidade de nutrientes em cultivos sem solo.

ABSTRACT The aim of this study was to evaluate the efficiency of the porous ceramic cup extractors, associated with ion meters, for the determination of nutrients availability for bell pepper and melon crops in substrate. Substrate solution was acquired using aqueous extract 1:1.5 (v/v) and also the porous ceramic cup extractor. Electrical conductivity (EC), pH and macronutrient contents were determined for the substrate solution through analytical method. The concentrations of NO- and K+ in the solutions obtained with porous ceramic cup extractors, and the N and K contents in the diagnostic leaf for nutritional evaluation were also determined. The concentrations of NO3- and K+ using the porous ceramic cup extractors have strong correlation (r=0.96 and 0.92, respectively) with the ones obtained using the standard method, as well as a moderate correlation (r=0.65) and a strong one (r=0.71) with contents of N and K, respectively, in the melon diagnostic leaf; and a weak correlation (r=0.36 and 0.26, respectively) in the bell pepper diagnostic leaf. The use of porous ceramic cup extractors for obtaining the substrate solution and the determination of the N-NO- and K+ contents by means of specific ion meters are a fast method of evaluating nutrients availability in soilless cultures.

ABSTRACT The objective was to evaluate the inclusion of chitosan (CHI) and technical cashew nut shell liquid (CNSLt) as natural feed additives in cattle diets on nutrient digestibility, ruminal fermentation, and in vitro gas production kinetics. We conducted a completely randomized design with 5×4 factorial arrangement, with 20, 35, 50, 65, and 100% Tifton 85 hay and four additives, monensin (200 mg/kg DM), CNSLt (500 mg/kg DM), CHI (500 mg/kg DM), and CNSLt+CHI (500 mg/kg DM/each). Dry matter (DM) and organic matter (OM) digestibility showed a linear reduction according to forage levels. The highest DM digestibility was observed with CHI on cattle diets. Inclusion of CHI increased DM digestibility. The highest in vitro organic matter and crude protein (CP) digestibilities were observed for CNSLt+CHI. The in vitro dry matter digestibility increased linearly with concentrate in the diet. There was interaction of forage:concentrate ratio and the additives for neutral detergent fiber, acid detergent fiber and hemicellulose digestibility. Chitosan, CNSLt, and CNSLt+CHI promoted the lowest acetate:propionate ratio compared with monensin. Total gas production showed interaction of the forage:concentrate ratio and additives. Lag time was lowest with CNSLt+CHI. Chitosan and CNSLt can be considered alternative fermentation modulators to ionophores by improving nutrient digestibility and increasing ruminal propionate concentrations.

RESUMO O consórcio de hortaliças é um sistema de cultivo que utiliza a complementaridade entre espécies para aumentar a rentabilidade da atividade agrícola. Nesse sentido, o objetivo deste trabalho foi avaliar o efeito das espécies almeirão e rúcula em consórcio com a couve na produtividade das culturas e no índice de eficiência do uso da área (EUA). Seis tratamentos (espécies em consórcio e em monocultura) foram avaliados em delineamento experimental de blocos casualizados, com quatro repetições. Foram utilizadas as cultivares ‘Top Bunch’ (couve), ‘Pão de Açúcar’ (almeirão) e ‘Folha Larga’ (rúcula). A produtividade da couve em monocultura não diferiu das obtidas em consórcios com almeirão, rúcula ou com ambas as espécies, enquanto as produtividades do almeirão e da rúcula foram maiores no monocultivo. Entretanto, mesmo com perdas de produtividade pelo almeirão e rúcula, os índices de EUA foram maiores que 1,0 em todas as consorciações indicando a viabilidade do consórcio. Maior índice EUA (2,41) foi obtido no consórcio de almeirão-rúcula-couve.

ABSTRACT Vegetable intercropping systems use complementarity between species to increase agricultural profitability. This study evaluated the effects of intercropping chicory and arugula species with collard greens on crop yield and land use efficiency (LUE). Six treatments, consisting of species planted as monocultures or intercropped in various combinations, were evaluated in a randomized block design with four replicates. The cultivars ‘Top Bunch’ (collard greens), ‘Pão de Açúcar’ (chicory) and ‘Folha Larga’ (arugula) were used. The yield of collard greens in monoculture did not differ from those obtained when they were intercropped with chicory, arugula, or both species, whereas chicory and arugula yields were higher in monoculture. However, even with yield losses for chicory and arugula in intercropping, LUE indices were greater than 1.0 in all intercropping systems, indicating their viability. The highest LUE index (2.41) was obtained in the chicory-arugula-collard green intercropping system.

RESUMO O parcelamaneto da adubação nitrogenada pode ser uma estratégia eficiente de gerenciamento nutricional para melhorar a produtividade, qualidade das plantas e reduzir o impacto ambiental negativo causado pelas perdas de nitrogênio (N).Nesse contexto, o presente estudo investigou o efeito do manejo de N nas características agronômicas de plantas de rúcula cultivadas em campo. Foram avaliados nove tratamentos, em delineamento experimental de blocos ao acaso, em esquema fatorial 4 x 2 + 1, com três repetições. Os fatores avaliados foram doses de N (60, 120, 180 e 240 kg ha-1 de N), parcelamento da adubação nitrogenada em cobertura (duas e três vezes) e um tratamento adicional sem a aplicação de N. Máxima altura foi obtida com a aplicação de 198 kg ha-1 de N. O aumento das doses de N promoveu o aumento do teor de nitrato, da massa fresca e da produtividade da rúcula. Não houve efeito do parcelamento da adubação nitrogenada em cobertura nas características avaliadas. Assim, o fornecimento de 240 kg ha-1 de N, aplicado em duas parcelas foi considerado como o melhor manejo.

ABSTRACT Splitting nitrogen (N) fertilizer application can be an efficient nutrient management technique to improve productivity and plant quality, as well as to reduce the negative environmental impact caused by N losses. In this context, the present study investigated how the management of N affects the agronomic characteristics of field-grown arugula plants. Nine treatments were assessed in a randomized complete block design, in a 4 x 2 + 1 factorial scheme, with three replicates. The evaluated factors were doses of N (60, 120, 180 and 240 kg N ha-1), split N fertilizer applications at side-dress (two and three times) and an additional treatment without a N supply. Maximum height was obtained with the application of 198 kg N ha-1. Nitrate content, fresh mass and productivity increased with increasing N doses. There was no effect of split N fertilizer applications on the characteristics evaluated. Therefore, the supply of 240 kg N ha-1 divided into two portions was considered as the best management strategy.

RESUMO Em sistemas intensivos de cultivo de hortaliças é natural o aumento de teores de nutrientes no solo devido às frequentes aplicações de fertilizantes, em especial de fósforo (P). Existem poucos estudos sobre a resposta das olerícolas à fertilização fosfatada nessas condições. Nesse contexto, o presente estudo teve como objetivo avaliar o desempenho agronômico da rúcula em função da adubação fosfatada em Latossolo com elevado teor do nutriente. Cinco doses de P (0, 50, 100, 200 e 300 kg ha-1 de P2O5) foram avaliados em delineamento de blocos ao acaso com quatro repetições. Máximo teor de P no solo e teor de P na parte aérea na colheita foram obtidos com a aplicação de 300 kg ha-1 de P2O5. A rúcula respondeu negativamente à adubação fosfatada. O aumento das doses de P promoveu redução da altura e produtividade da cultura.

ABSTRACT In intensive vegetable production systems, it is natural to increase nutrient contents in the soil due to the frequent fertiliser applications, especially phosphorus (P). There are few studies on the response of vegetables to phosphate fertilisation under such conditions. In this context, the objective of this study was to evaluate the agronomic performance of rocket as a function of phosphorus fertilisation in a P-rich Rhodic Eutrudox soil. Five P doses (0, 50, 100, 200, and 300 kg ha-1 P2O5) were evaluated in a randomised complete block design with four replicates. Maximum soil P content and shoot P content at harvest were obtained at a dose of 300 kg ha-1 P2O5. Rocket responded negatively to P fertilisation. The increase of P doses promoted the decrease of height and yield of the crop.

RESUMO A adequada relação no fornecimento de nitrogênio (N) e potássio (K) para cada estádio fenológico do meloeiro é fundamental para seu crescimento e desenvolvimento, com maximização da partição de massa seca entre as partes vegetativas e reprodutivas. O objetivo deste trabalho foi avaliar a influência de concentrações de N e K para duas fases fenológicas (vegetativa e reprodutiva) do meloeiro e obter a melhor relação N:K para cada uma delas. Na primeira fase, foram avaliadas quatro concentrações de N (8, 11, 14 e 17 mmol L-1) e duas concentrações de K (4 e 5 mmol L-1), em delineamento experimental de blocos ao acaso, em esquema fatorial 4x2, com cinco repetições. Na segunda fase, em esquema fatorial 2x2, foram avaliadas as combinações das duas concentrações de N que geraram as melhores características na fase anterior e duas concentrações de K (4,5 e 9,0 mmol L-1). O aumento da concentração de N na fase vegetativa promoveu o aumento dos teores foliares de N, P e S e a redução de K, Ca e Mg. Além disso, aumentou o número de folhas, a altura da planta (tutorada verticalmente) e a área foliar. Por isso, 17:5 mmol L-1 foi considerada como melhor relação N:K para a fase vegetativa. Na segunda fase, não houve efeito das concentrações de N e de K sobre a área foliar, produtividade e a qualidade dos frutos do meloeiro e, assim, considerou-se 14:4,5 mmol L-1 como a melhor relação N:K para a fase reprodutiva.

ABSTRACT The adequate ratio in the supply of nitrogen (N) and potassium (K) for each phenological growth stage of melon is fundamental for its growth and development with the maximization of the dry mass partition between the vegetative and reproductive parts. The objective of this study was to evaluate the influence of N and K concentrations in two phenological growth stages (vegetative and reproductive stage) of melon and obtain the best N:K ratio for each one. In the first stage, four concentrations of N (8, 11, 14 and 17 mmol L-1) and two concentrations of K (4 and 5 mmol L-1) were evaluated in a randomized block design in a 4 × 2 factorial scheme with five replicates. In the second stage, in a 2 × 2 factorial scheme, the combinations of the two concentrations of N that generated the best characteristics in the previous stage and two concentrations of K (4.5 and 9.0 mmol L-1) were evaluated. The increase of the N concentration in the vegetative stage promoted the increase of the N, P and S content of leaves and the reduction of K, Ca and Mg. Moreover, it increased the number of leaves, the height of the plant (vertically tutored) and the leaf area. Therefore, 17:5 mmol L-1 was considered as the best N:K ratio for the vegetative stage. In the second stage, there was no effect of N and K concentrations on leaf area, yield and fruit quality. So, 14:4.5 mmol L-1 was considered as the best N:K ratio for the reproductive stage.

Abstract Objective: To study the adherence of Streptococcus mutans biofilm after induction with sucrose and xylitol. Material and Methods: Laboratory experimental study incorporating posttest-only control group design. S. mutans biofilm was generated for 24 hours at a temperature of 37°C using BHIB with 5% sucrose and BHIB with 1% xylitol. An adherence assay was conducted in accordance with the method applied previously. The quantity of adhered bacteria was measured by means of a spectrophotometer at 570 nm. The data were presented as mean and standard deviation. Results: A biofilm induced with sucrose has a higher adherence level (0.9294 ± 0.0431) compared with one induced with xylitol (0.5095 ± 0.0392). Sucrose induces adherence levels by increasing glucan binding protein and glucosyltransferase of the bacteria, whereas xylitol will inhibit the glycolysis process of the bacteria. Conclusion: The adherence of sucrose-induced S. mutans biofilm is higher than that of xylitol-induced S. mutans biofilm.

Abstract Recent molecular tools and technologies have marked the discovery of the origin and domestication processes of a wide variety of species, using either genomic or mitochondrial molecular markers to provide input for selection programs, as well as the management and conservation of animal breeds. This study aimed to analyze genes of mitochondrial DNA of the following sheep (Ovis aries) breeds: Pantaneira, Bergamácia, Dorper, White Dorper, Ile de France and Hampshire Down, to obtain their population genetic parameters and investigate the origin of these sheep populations reared in the State of Mato Grosso do Sul. The analysis of mitochondrial DNA allowed to infer their phylogenetic relationships and revealed significant differences among them when compared with each other and with sequences obtained from GenBank. Through the formation of haplotypes, it was noted that the Pantaneira breed served as the maternal basis for the formation of the other breeds reared in the region, and it was possible to suggest a European origin for the sheep populations studied.

RESUMO Objetivo: apresentar a história do Congresso Brasileiro de Fonoaudiologia, expondo sua organização e caracterizando parte da produção científica publicada em seus anais nos últimos dez anos. Métodos: trata-se de um estudo teórico, descritivo-exploratório, com fonte de dados bibliográfica. A análise foi fundamentada nos dados disponíveis no site da Sociedade Brasileira de Fonoaudiologia e restrita aos últimos dez anos. Os achados consideraram o ano, a categoria e a área de inscrição do trabalho. A análise estatística utilizou o programa Statistical Package for Social Sciences. Resultados: desde 2006 onze especialidades foram reconhecidas. As áreas disponíveis para submissão de trabalhos sofreram alterações entre 2008 e 2011. No período de 2012 a 2017 foram identificados 7296 participantes e 5166 publicações com progressiva redução em ambos desde 2014. Em 2017, a quantidade de trabalhos foi maior do que a de participantes. As submissões na categoria “tese/dissertação” registraram um aumento de 110%. A área “Voz” teve o maior número de trabalhos do período. Conclusão: o aumento no número de especialistas somado aos avanços tecnológicos podem justificar, parcialmente, a redução no número de participantes; porém, novos remanejamentos se fazem necessários como forma de manter o evento atualizado e atrativo caminhando de encontro às novas tendências da profissão.

ABSTRACT Objective: to present the history of the Brazilian Speech Therapy and Audiology Congress, exposing its organization and characterizing part of the scientific production published in its annals in the last ten years. Methods: a theoretical, descriptive-exploratory study, with a bibliographic data source. The analysis was based on data available on the website of the Brazilian Society of Speech Therapy and Audiology, and restricted to the last ten years. The findings considered the year of publication, the publication category and the study area. The statistical analysis applied the Statistical Package for Social Sciences. Results: since 2006 eleven specialties have been recognized. The areas available for submitting papers changed between 2008 and 2011. From 2012 to 2017, 7,296 participants and 5,166 publications were identified. A decrease in both publications and participants is seen since 2014. In 2017, the number of papers was higher than the number of participants. Submissions in the "thesis/dissertation" category increased by 110%. Papers of a specific field related to the human voice presented the highest number of papers in the period. Conclusion: the increase in the number of specialists, added to technological advances, may partially justify a reduction in the number of participants; however, new relocations are necessary as a way to keep the event up to date and attractive, in face of the profession’s new trends.

RESUMO A consorciação de culturas é um sistema de produção capaz de reduzir os custos produtivos e aumentar a rentabilidade dos produtores de hortaliças, uma vez que ele possibilita o uso mais eficiente da área e dos insumos agrícolas. Com o objetivo de avaliar o efeito da densidade de plantas de alface na viabilidade econômica do consórcio de alface e rúcula, em duas épocas de cultivo (inverno e verão), dois experimentos foram instalados em campo, na Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Jaboticabal, São Paulo, Brasil. Os tratamentos corresponderam a cinco consórcios de alface com rúcula nos espaçamentos entre linhas da alface de: 0,20; 0,25; 0,30; 0,35 e 0,40 m, cinco cultivos solteiros de alface nos mesmos espaçamentos adotados em consórcio, e um cultivo solteiro de rúcula no espaçamento entre linhas de 0,20 m. O delineamento experimental utilizado foi em blocos casualizados completos, com quatro repetições. No inverno, maior rentabilidade é obtida com a maior densidade populacional. Maior rentabilidade das culturas, em ambas épocas de cultivo é obtida no verão.

ABSTRACT Intercropping is a production system that can reduce the production cost and increase the profitability of vegetable producers, since it permits more efficient land and agricultural inputs use. In order to evaluate the effect of lettuce plant density on the economic feasibility of lettuce-rocket intercropping system over two growing seasons (winter and summer), two experiments were conducted in the field at São Paulo State University “Júlio de Mesquita Filho” (UNESP), Jaboticabal, São Paulo, Brazil. The treatments consisted of five lettuce-rocket intercrops with spacing between lettuce rows of: 0.20; 0.25; 0.30; 0.35 and 0.40 m, five sole crop of lettuce in the same spacing between rows adopted in the intercropping system, and a sole cropping of rocket with spacing between rows of 0.20 m. The statistical design adopted was the complete randomized block with four replicates. During winter, higher profitability was achieved with the highest population density. Highest profitability of the crops in both seasons was obtained in summer.

ABSTRACT The objective of this work was to study the behavior of swine females in the grower phase using different observation intervals (continuous, 5, and 10 min). A total of 42 swine were used, 14 of them for each treatment, which were identified with a marker stick. These animals were observed using the focal sampling method for 5 h. The treatments were the observation intervals: continuous, every 5 min, and every 10 min. Among the behaviors analyzed during the experiment, the different observation intervals did not affect the estimated time spent in the activities. Time observation intervals of 10 min or less adequately describe the duration of the main behavioral parameters of female pigs in this setting.

RESUMO Objetivou-se avaliar o efeito da inclusão de glicerina bruta (GB) em substituição ao milho, na dieta de cordeiros Pantaneiros confinados, sobre as características da carcaça e qualidade da paleta e do pernil. Foram utilizados 24 cordeiros machos, não castrados, em delineamento inteiramente casualizado, com quatro tratamentos (0, 2,5, 5,0 e 7,5% de GB em base da MS). Não houve efeito da inclusão de GB sobre os não componentes de carcaça. Houve efeito quadrático para peso de carcaça quente, com menor valor para 2,5% de GB. A composição regional e tecidual da carcaça não foi alterada pela substituição do milho pela GB. A composição tecidual da paleta e pernil e as características instrumentais da paleta não foram afetadas pelos teores de GB. Houve efeito quadrático para a intensidade de amarelo do pernil, com maior valor para 5,0% de GB. O teor de extrato etéreo da paleta apresentou efeito linear decrescente. Pode-se recomendar a utilização de 7,5% de GB, na matéria seca, em substituição ao milho, sem alteração das características da carcaça e qualidade da carne.

SUMMARY The objective was to assess the effect of inclusion of crude glycerin (CG) replacing corn in the diet of feedlot Pantaneiro lambs on the non-carcass components, regional and tissue composition, and carcass traits. Were used 24 not castrated males, in a completely randomized design with four treatments (0, 2.5, 5.0 and 7.5% of CG on DM basis). There was no effect of GB inclusion on non-carcass components. There was a quadratic effect for hot carcass weight, with lower value to 2.5% of CG. Regional and tissue composition of the carcass was not affected by the substitution of corn by CG. The tissue composition of shoulder and leg and instrumental traits of the shoulder were not affected by CG. There was a quadratic effect for the yellowness of the leg, with high value for 5.0% of GB. The ether extract content of shoulder showed decreased linear effect. The use of 7.5% of CG, in dry matter, can be recommend to replace corn of feedlot diets, without changing carcass traits and meat quality.

ABSTRACT This study assessed the use of conformation and fatness scores of the EUROP sheep carcass grading system to predict weight and percentage of salable meat from Brazilian market lambs. Data were collected from in vivo, carcass, and retail production from 252 uncastrated lambs. Evaluated models included single regressions, two multivariate models, and one determined by the stepwise procedure. Conformation was moderately correlated with weight of salable meat. Fatness scores were correlated with rump perimeter, carcass width, and thoracic depth with coefficients of −0.33, −0.32, and −0.23, respectively. Body weight was the best single predictor for weight of salable meat and cold carcass yield for percentage of salable meat. All multivariate models for weight of salable meat prediction were significant. Stepwise regression with body weight, leg perimeter, thoracic depth, rump perimeter, and fatness scores predicted 98% of weight of salable meat variation. For percentage of salable meat prediction, stepwise regression with cold carcass yield, leg perimeter, and conformation score was significant. The EUROP conformation and fatness scores can be used in Brazil for the prediction of lamb meat production.

ABSTRACT PURPOSE: To evaluate the efficacy of ethyl-cyanoacrylate in the treatment of fístula-in-ano in rats with and without prior seton placement. METHODS: Thirty rats Wistar with fístula-in-ano produced surgically, distributed in three groups: group A (ethyl-cyanoacrylate) - treated by application of ethyl-cyanoacrylate into fístula tract; group B (seton + ethyl-cyanoacrylate) - seton placement followed by application of ethyl-cyanoacrylate into fístula tract, 30 days later; group C (control) - no treatment. After 60 days the animals were submited to euthanasia and the specimens were analyzed by pathologist. The results were analyzed by Chi-square test with significant value of p<0.05. RESULTS: One animal of group B died. Were found tracts fully healed: 7, 5 and 2, in groups A, B and C, respectivelly. There was a statistically significant difference between groups A and C (p=0.02). When joined all animals treated with glue (A + B) compared to group C there was also statistically significant difference (p=0.02). CONCLUSIONS: The use of ethyl-cyanoacrylate glue was effective in closing anal fistulae in rats. There was no advantage in the prior application of seton.