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Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

Light-curve responses in Atriplex nummularia L. irrigated with saline water
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Lins, Cíntia Maria Teixeira

; Souza, Edivan Rodrigues de

; Monteiro, Danilo Rodrigues

; Paulino, Martha Katharinne Silva Souza

; Melo, Hidelblandi Farias de

; Dourado, Pablo Rugero Magalhães

; Cunha, Jailson Cavalcante

; Santos, Monaliza Alves dos

; Schaffer, Bruce

Revista de Ciências Agrárias

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sep 2022, Volume 45 N. 3 Pages 21 - 30

Abstract: En | Text: En | PDF: En

Abstract Atriplex nummularia L. is one of the most studied halophytes in research on phytoremediation of salt-affected soils. However, the optimization of biomass requires studies that indicate the appropriate way to evaluate the photosynthesis. The objective of this study was to investigate the photosynthetic efficiency of A. nummularia irrigated with saline water in order to indicate the best range of photosynthetically active radiation (PAR) that should be used. Plants were subjected to daily irrigations (0, 50, 100, 200, 250 and 300 mmol L-1 of NaCl). The light curves were determined at 15 and 84 days applying twenty light intensities (2000, 1750, 1500, 1250, 1000, 750, 500, 250, 200,175, 150, 125, 100, 75, 50, 25, 15, 10, 5, 0 μmol m-2 s-1 PAR). The highest values of photosynthesis rate were observed at PAR of 2000 μmol m-2 s-1 and of 800 μmol m-2 s-1 to 15 and 84 days of evaluation, independent of the NaCl concentration. The present study provides data that support the choice of the ideal PAR in evaluations of gas exchange in A. nummularia.

https://doi.org/10.19084/rca.27265

Major depressive episode in mothers during the COVID-19 pandemic: a population-based study in the Southern Brazil
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Coelho, Fernanda Teixeira

; Scholl, Carolina Coelho

; Trettim, Jéssica Puchalski

; Silveira, Jaqueline Buzetto

; Mello, Daniele Behling de

; Santos, Martha Rodrigues dos

; Ferreira, Lidiane Aguiar

; Stigger, Rafaelle Stark

; Matos, Mariana Bonati de

; Pinheiro, Ricardo Tavares

; Quevedo, Luciana de Avila

Cadernos de Saúde Pública

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2022, Volume 38 N. 4 elocation EN281521

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

A pandemia da COVID-19 tem levado a mudanças em indivíduos e famílias, com efeitos psicológicos adversos, principalmente em adultos jovens, mulheres e pais e mães. O estudo buscou averiguar a prevalência de episódio depressivo maior atual (EDMA) em mães de pré-escolares (até 5 anos de idade) e estressores associados durante a pandemia da COVID-19 em uma cidade no Sul do Brasil. Este é um estudo transversal aninhado em um estudo de base populacional com mães. Todas as mães foram entrevistadas através de contato telefônico durante a pandemia da COVID-19. Os autores usaram a Mini-International Neuropsychiatric Interview (M.I.N.I. Plus) para avaliar a presença de EDMA. A análise estatística foi realizada, calculando o qui-quadrado e a regressão logística multivariada. Foram avaliadas 666 mães. A prevalência de EDMA foi de 12,3%. Mães com perdas financeiras apresentaram probabilidade 2,1 vezes maior (IC95%: 1,3-3,4) de apresentar EDMA, comparadas com aquelas que mantiveram a situação financeira. Com base nos resultados, os autores observaram que perdas financeiras foram determinantes para a prevalência maior de depressão materna.

The COVID-19 pandemic has changed individuals and families, causing adverse psychological effects, especially in young adults, women, and parents. This study aimed to verify the prevalence of current major depressive episode (CMDE) in mothers of preschoolers (up to five years old) and its associated stressors during the COVID-19 pandemic in a municipality in the Southern Brazil. This is a cross-sectional, population-based study with mothers. All mothers were interviewed by telephone call during the COVID-19 pandemic. We used the Mini-International Neuropsychiatric Interview (M.I.N.I. Plus) to assess the presence of CMDE. Statistical analysis was conducted using the chi-square test and a multivariate logistic regression. We evaluated 666 mothers. The prevalence of CMDE was 12.3%. Mothers with financial losses had 2.1 (95%CI: 1.3-3.4) more odds of presenting CMDE than those financially stable. We observed that financial losses were determinant for the higher prevalence of depression in mothers.

La pandemia de COVID-19 ha provocado cambios en los individuos y las familias, causando efectos psicológicos adversos, especialmente en los adultos jóvenes, las mujeres y los padres y madres. El objetivo de este estudio fue verificar la prevalencia del episodio depresivo mayor actual (EDMA) en madres de preescolares (hasta 5 años) y sus estresores asociados durante la pandemia de COVID-19 en una ciudad del sur de Brasil. Se trata de un estudio transversal anidado en un estudio poblacional con madres. Todas las madres fueron entrevistadas mediante contacto telefónico durante la pandemia de COVID-19. Se utilizó la Mini-International Neuropsychiatric Interview (M.I.N.I. Plus) para evaluar la presencia de EDMA. El análisis estadístico se realizó calculando la prueba de chi-cuadrado y una regresión logística multivariante. Se evaluaron 666 madres. La prevalencia de EDMA fue del 12,3%. Las madres con pérdidas económicas tenían un 2,1 (IC95%: 1,3-3,4) más probabilidades de presentar EDMA que las que mantuvieron su situación económica. Teniendo en cuenta los resultados, observamos que las pérdidas económicas fueron determinantes para la mayor prevalencia de depresión materna.

https://doi.org/10.1590/0102-311xen281521

Major depressive episode in mothers during the COVID-19 pandemic: a population-based study in the Southern Brazil
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Coelho, Fernanda Teixeira

; Scholl, Carolina Coelho

; Trettim, Jéssica Puchalski

; Silveira, Jaqueline Buzetto

; Mello, Daniele Behling de

; Santos, Martha Rodrigues dos

; Ferreira, Lidiane Aguiar

; Stigger, Rafaelle Stark

; Matos, Mariana Bonati de

; Pinheiro, Ricardo Tavares

; Quevedo, Luciana de Avila

Cadernos de Saúde Pública

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2022, Volume 38 N. 4 elocation EN281521

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311xen281521

Physicochemical and sensory evaluation of mortadella based on Nile tilapia filleting residues
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Alda, Paola Casagrande

; Coradini, Melina Franco

; Chambo, Ana Paula Sartório

; Correa, Stefane dos Santos

; Mikcha, Jane Martha Graton

; Goes, Elenice Souza dos Reis

; Souza, Maria Luiza Rodrigues de

Ciência Rural

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2021, Volume 51 N. 3 elocation e20190979

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste trabalho foi elaborar e caracterizar mortadelas a partir de aparas da filetagem (corte em “V” do filé) de tilápia do Nilo, de forma a possibilitar a agregação de valor a este subproduto do processo de filetagem. Foram elaboradas três mortadelas, sendo uma com 100% de aparas da filetagem de tilápia, outra contendo 100% de carne de frango e a terceira com 100% de carne suína. As mortadelas foram caracterizadas quanto à microbiologia, composição química, cálcio, colágeno, pH, Aw, cor, textura e custo de formulação. As mortadelas estavam dentro dos padrões microbiológicos recomendados. A mortadela de tilápia apresentou maiores teores de umidade, cinzas, cálcio e colágeno, maior pH e menor atividade de água quando comparada às demais espécies. A mortadela de tilápia apresentou menor luminosidade, maior croma a* e croma b* intermediário às demais. A textura foi melhor para as mortadelas de tilápia, quanto a dureza, gomosidade e mastigabilidade, cujos valores foram menores. A mortadela de frango teve maior índice de aceitação, porém, a de tilápia também foi elevado, enquanto de suíno todos os atributos avaliados receberam as piores notas. A mortadela de tilápia do Nilo é uma inovação tecnológica que pode ser introduzida no setor alimentício com bom valor nutricional e bom índice de aceitação.

ABSTRACT: The objective of this research was to elaborate and characterize mortadella using fillet residues (‘V’-cut fillet trim) of Nile tilapia, in order to add value to this by-product of the filleting process. Three mortadellas were made, one with 100% tilapia fillet trimmings, another containing 100% chicken meat and the third with 100% pork meat. Mortadellae were characterized in terms of microbiology, chemical composition, calcium, collagen, pH, Aw, colour, texture and formulation cost. Mortadella was within the recommended microbiological standards. Tilapia mortadella had higher levels of moisture, ash, calcium and collagen, higher pH and lower water activity when compared to other species. The tilapia mortadella had lower brightness, higher chroma a * and intermediate chroma b *, compared with the others. The texture of tilapia mortadella was better in terms of hardness, gumminess and chewability, the values of which were lower. The chicken mortadella had a higher acceptance rate; however, that of tilapia was also high, while all evaluated attributes of pork received the worst grades. Nile tilapia mortadella is a technological innovation that can be introduced into the food sector with good nutritional value and a good acceptance index.

https://doi.org/10.1590/0103-8478cr120190979 700 downloads

Comparison of water and osmotic potentials on Vigna unguiculata stress response
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Melo, Hidelblandi Farias de

; Souza, Edivan Rodrigues de

; Dourado, Pablo Rugero Magalhães

; Lins, Cíntia Maria Teixeira

; Santos, Hugo Rafael Bentzen

; Monteiro, Danilo Rodrigues

; Paulino, Martha Katharinne Silva Souza

; Almeida, Brivaldo Gomes de

; Santos, Monaliza Alves dos

Revista Brasileira de Ciência do Solo

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2020, Volume 44 elocation e0200070

Abstract: En | Text: En | PDF: En

ABSTRACT Drought and soil salinity are the main abiotic stresses in semiarid regions of the world. This study aims to evaluate the effect of water tensions generated by the reduction of soil moisture and salt on the leaf water potential of cowpea (Vigna unguiculata L. Walp). The experiments were conducted in a randomized complete block design, with a 6 × 2 factorial arrangement consisted of six soil water tensions (0.025, 0.265, 0.485, 0.705, 0.925, and 1.145 MPa) and two tension sources (water deficit and salt), with four replications. Two experiments were performed with the same environmental conditions to evaluate the influence of the tensions on vegetative and reproductive stages. Water and osmotic potentials, relative water content, leaf succulence, and shoot biomass yield were evaluated. Soil water tension was not the main factor of changes on water and osmotic potentials of V. unguiculata plants; the water deficit treatments at soil water tensions of up to 1.145 MPa did not reduce the water and osmotic potentials either at the vegetative or flowering phenological stages; high correlations were found between shoot biomass yield and the leaf water potential at seven days after stress. The osmotic potential was the main indicator of stress in plants at the vegetative and flowering stages subjected to water deficit by the presence of salts in the soil solution.

https://doi.org/10.36783/18069657rbcs20200070 323 downloads

Improvement in spray-drying technology for preparation of pregelatinized cassava starch
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SANTOS, Thais Paes Rodrigues dos

; FRANCO, Célia Maria Landi

; MISCHAN, Martha Maria

; LEONEL, Magali

Food Science and Technology

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dec 2019, Volume 39 N. 4 Pages 939 - 946

Abstract: En | Text: En | PDF: En

Abstract Native cassava starch was gelatinized under different pretreatment conditions (preheating temperature, starch concentration and heating time) and spray-dried. A rotational compound central design was used to test the three independent variables: the preheating temperature, starch concentration, and heating time, and the behavior of the system was assessed by response surface methodology. The results showed a significant effect of both the preheating temperature and heating time on the cold viscosity. The combination of the preheating temperature and starch concentration affected the crystallinity, enthalpy change, solubility, and final viscosity. Modification by spray-drying resulted in a decrease in the crystalline regions, and enthalpy change, as well as an increase in the cold viscosity. The optimal conditions for obtaining partially gelatinized cassava starch with high cold viscosity and lower breakdown, desirable characteristics for commercial pregelatinized starch, are as follows: starch concentration of 25%, preheating temperature of 52 °C, and processing heating time of 10 min.

https://doi.org/10.1590/fst.10418 911 downloads

Asymptomatic Plasmodium infection in a residual malaria transmission area in the Atlantic Forest region: Implications for elimination
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Miguel, Renata Bortolasse

; Albuquerque, Hermano Gomes

; Sanchez, Maria Carmen Arroyo

; Coura, José Rodrigues

; Santos, Simone da Silva

; Silva, Sidnei da

; Moreira, Carlos José de Carvalho

; Suárez-Mutis, Martha Cecilia

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180537

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: Elimination of malaria in areas of interrupted transmission warrants careful case assessment to avoid the reintroduction of this disease. Occasional malaria cases are reported among visitors of the Atlantic Forest area of Brazil, while data on residents of this area are scarce. METHODS: A sectional study was carried out to examine 324 individuals living in a municipality where autochthonous cases were detected. RESULTS: Asymptomatic Plasmodium infections were detected in 2.8% of the individuals by polymerase chain reaction (PCR), with one case of P. falciparum (0.3%), two cases of P. vivax (0.6%), and six cases of P. malariae (1.9%). The thick blood smears were negative in all individuals. Serological tests performed in 314 subjects were reactive in 11.1%, with 3.5% for P. falciparum and 7.7% for P. vivax. A subsample of 42 reactive individuals for any Plasmodium species showed P. malariae in 30.9% of specimens. Individuals who entered the Atlantic Forest region were 2.7 times more likely to exhibit reactive serology for P. vivax compared with individuals who did not enter this region (p<0.05). Children <15 years had a higher chance of reactive serology for P. falciparum and P. vivax than individuals ≥15 years of age (p<0.05). Individuals living in the Paraiso district had a higher chance of reactive serology for P. vivax compared to other districts (p<0.05). No associations were found between sex, past exposure to malaria, or serological response to antibodies of any Plasmodium species. CONCLUSIONS: The implications of these results for the elimination of malaria were discussed.

https://doi.org/10.1590/0037-8682-0537-2018 3156 downloads

Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis
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Villela, Anne Drumond

; Rodrigues Junior, Valnês da Silva

; Pinto, Antônio Frederico Michel

; Wink, Priscila Lamb

; Sánchez-Quitian, Zilpa Adriana

; Petersen, Guilherme Oliveira

; Campos, Maria Martha

; Basso, Luiz Augusto

; Santos, Diógenes Santiago

Memórias do Instituto Oswaldo Cruz

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mar 2017, Volume 112 N. 3 Pages 203 - 208

Abstract: En | Text: En | PDF: En

BACKGROUND Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. The better understanding of important metabolic pathways from M. tuberculosis can contribute to the development of novel therapeutic and prophylactic strategies to combat TB. Nucleoside hydrolase (MtIAGU-NH), encoded by iunH gene (Rv3393), is an enzyme from purine salvage pathway in M. tuberculosis. MtIAGU-NH accepts inosine, adenosine, guanosine, and uridine as substrates, which may point to a pivotal metabolic role. OBJECTIVES Our aim was to construct a M. tuberculosis knockout strain for iunH gene, to evaluate in vitro growth and the effect of iunH deletion in M. tuberculosis in non-activated and activated macrophages models of infection. METHODS A M. tuberculosis knockout strain for iunH gene was obtained by allelic replacement, using pPR27xylE plasmid. The complemented strain was constructed by the transformation of the knockout strain with pNIP40::iunH. MtIAGU-NH expression was analysed by Western blot and LC-MS/MS. In vitro growth was evaluated in Sauton’s medium. Bacterial load of non-activated and interferon-γ activated RAW 264.7 cells infected with knockout strain was compared with wild-type and complemented strains. FINDINGS Western blot and LC-MS/MS validated iunH deletion at protein level. The iunH knockout led to a delay in M. tuberculosis growth kinetics in Sauton’s medium during log phase, but did not affect bases and nucleosides pool in vitro. No significant difference in bacterial load of knockout strain was observed when compared with both wild-type and complemented strains after infection of non-activated and interferon-γ activated RAW 264.7 cells. MAIN CONCLUSION The disruption of iunH gene does not influence M. tuberculosis growth in both non-activated and activated RAW 264.7 cells, which show that iunH gene is not important for macrophage invasion and virulence. Our results indicated that MtIAGU-NH is not a target for drug development.

https://doi.org/10.1590/0074-02760160462 1740 downloads

10.

Avaliação econômica dos casos de Dengue atribuídos ao desastre de 2011 em Nova Friburgo (RJ), Brasil
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Pereira, Carlos Alexandre Rodrigues

; Barata, Martha Macedo de Lima

; Hoelz, Melania de Paulo Cariello

; Medeiros, Viviane Nunes Lopes Oliveira

; Marincola, Felipe de Carvalho Vommaro

; Costa Neto, Cristina

; Marinho, Diana Pinheiro

; Oliveira, Teresa Vieira dos Santos

; Trigo, Aline Guimarães Monteiro

; Medeiros, Thiago Klein de

Ciência & Saúde Coletiva

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sep 2014, Volume 19 N. 9 Pages 3693 - 3704

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A perspectiva apontada pelos cenários climáticos desenvolvidos para o Brasil é de provável aumento no número de eventos hidrometeorológicos extremos nos próximos anos. Por isso, se faz importante o estudo dos agravos em saúde que poderão se intensificar em decorrência desses eventos. Portanto, por meio deste artigo, propõe-se estimar o custo representado pelos casos de dengue atribuídos ao desastre de 2011, em Nova Friburgo (RJ). Verificou-se que ocorreram 1.356 casos suspeitos de dengue, dos quais 937 foram confirmados. O custo total da doença pode ter variado, no mínimo, entre R$ 66 mil e R$ 499 mil, no cenário de menor valor de salário, sendo que cerca de 70% desse custo ocorreu entre os casos confirmados. O desastre provocou grandes mudanças no ambiente do município que, junto com os problemas de saneamento e limpeza urbana, que ocorreram em períodos posteriores ao evento, acabou por aumentar a disponibilidade de locais que pudessem servir de criadouro do mosquito, facilitando sua proliferação e aumentando a incidência da dengue, doença que na década anterior ao desastre teve baixa incidência no município. Isso ilustra o potencial que eventos como ao ocorrido em 2011, em Nova Friburgo, podem ter no incremento desses casos e, consequentemente, nos custos da doença.

The prospects outlined in climate scenarios produced for Brazil indicate a probable increase in the number of extreme hydrometeorological events in the coming years. Therefore, a study of the health scourges that may intensify due to these events is important. The scope of this article is to estimate the cost represented by the cases of dengue fever attributed to the 2011 disaster in Nova Friburgo (RJ). There were 1,356 suspected cases of dengue fever, 937 of which were confirmed. The total cost of the disease may have been between R$66,000 and R$499,000 taking the minimum salary as a benchmark, with approximately 70% of this amount being among the confirmed cases. The disaster caused extensive changes in the city's environment which, together with the urban sanitation and clearing up process that occurred in the post-event period, led to an increase in the number of potential mosquito breeding sites, facilitating their proliferation and increasing the number of cases of dengue fever. This was a disease that in the decade prior to the disaster recorded few cases of the disease in the municipality. This illustrates the potential of events like the one that occurred in 2011 in Nova Friburgo may have on the increase in the number of cases, and consequently on the cost of the disease.

https://doi.org/10.1590/1413-81232014199.01682014 1887 downloads

11.

Avaliação econômica dos casos de Dengue atribuídos ao desastre de 2011 em Nova Friburgo (RJ), Brasil
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Pereira, Carlos Alexandre Rodrigues

; Barata, Martha Macedo de Lima

; Hoelz, Melania de Paulo Cariello

; Medeiros, Viviane Nunes Lopes Oliveira

; Marincola, Felipe de Carvalho Vommaro

; Costa Neto, Cristina

; Marinho, Diana Pinheiro

; Oliveira, Teresa Vieira dos Santos

; Trigo, Aline Guimarães Monteiro

; Medeiros, Thiago Klein de

Ciência & Saúde Coletiva

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sep 2014, Volume 19 N. 9 Pages 3693 - 3704

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232014199.01682014 3398 downloads

12.

Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
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Gomes, Larissa Rodrigues

; Totino, Paulo Renato Rivas

; Sanchez, Maria Carmen Arroyo

; Daniel, Elsa Paula da Silva Kaingona

; Macedo, Cristiana Santos de

; Fortes, Filomeno

; Coura, Jose Rodrigues

; Santi, Silvia Maria Di

; Werneck, Guilherme Loureiro

; Suarez-Mutis, Martha Cecilia

; Ferreira-da-Cruz, Maria de Fatima

; Daniel-Ribeiro, Claudio Tadeu

Memórias do Instituto Oswaldo Cruz

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sep 2013, Volume 108 N. 6 Pages 796 - 800

Abstract: En | Text: En | PDF: En

Anti-glycosylphosphatidylinositol (GPI) antibodies (Abs) may reflect and mediate, at least partially, anti-disease immunity in malaria by neutralising the toxic effect of parasitic GPI. Thus, we assessed the anti-GPI Ab response in asymptomatic individuals living in an area of the Brazilian Amazon that has a high level of malaria transmission. For comparative purposes, we also investigated the Ab response to a crude extract prepared from Plasmodium falciparum, the merozoite surface protein (MSP)3 antigen of P. falciparum and the MSP 1 antigen of Plasmodium vivax (PvMSP1-19) in these individuals and in Angolan patients with acute malaria. Our data suggest that the Ab response against P. falciparum GPI is not associated with P. falciparum asymptomatic infection in individuals who have been chronically exposed to malaria in the Brazilian Amazon. However, this Ab response could be related to ongoing parasitaemia (as was previously shown) in the Angolan patients. In addition, our data show that PvMSP1-19may be a good marker antigen to reflect previous exposure to Plasmodium in areas that have a high transmission rate of P. vivax.

https://doi.org/10.1590/0074-0276108062013018 2037 downloads

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