ABSTRACT In family farming, mechanisation, when appropriate to the task and to the size of the property, can be one way of easing tiring and repetitive work, such as garlic harvesting. The present study is based on a model of harvester currently on the market, and proposes several improvements for mechanising the harvest on family farms, with an emphasis on sloping terrain, to reduce costs and increase productivity. Since the equipment currently on the market reduces the operational performance of these producers resulting in the high prices of commercial garlic, the aim of this study was to evaluate, using the Finite Element Method, the von Mises stresses and the displacement of a garlic harvester in different topographies. A structural analysis was carried out, and the vibration modules in the three main parts that make up the structure of the garlic harvester were checked: the structure supporting the scarifier point, the structure of the plant transport system, and the structure at the rear of the harvester. The structural modifications that were implemented corrected the initial high-stress conditions, showing improvements in stress concentration and areas of displacement. As such, the entire structure of the garlic harvester tends to withstand the proposed loads. From the results of the simulations, we conclude that the connecting support may undergo greater response from structural dynamics, and that frequencies greater than 45.7 Hz should be avoided since there are several natural frequencies above this range that might cause interference to the structure.

ABSTRACT Tomatoes are a highlight in the organic vegetables production, but in order to cultivate them, there is a lack of information on cultivars adapted to the organic system. The objective of this study was to evaluate the productive performance and to characterize the quality attributed to tomato fruits under the organic production system. The experiment was conducted in field, on an agroecological farm , in the municipality of Verê, Paraná State - Brazil. The experiment consisted on fourteen tomato cultivars, under a randomized complete block design, with four replications. The evaluated traits were the total and commercial fruit production, total and commercial number of fruits, mass and average diameter of commercial fruits and physicochemical quality traits (firmness, pH, color (L*, C and h°), soluble solids (SS), titratable acidity (TA), and the ratio of SS/TA). Considering together production traits and fruit quality aspects, the cultivars Netuno, Aguamiel, and Cordilheira can be considered the best choices, having potential to be recommended for organic production system.

Resumo O presente estudo tem como objetivo avaliar a influência da colaboração na cadeia de suprimentos sobre o desempenho operacional das indústrias de médio e grande porte do segmento Têxtil e Metalmecânico do Vale do Itajaí (SC). São consideradas práticas colaborativas a cultura colaborativa, planejamento conjunto, resolução conjunta de problemas e compartilhamento de recursos e informações. O estudo foi delineado sob a abordagem quantitativa, quanto aos objetivos descritiva e survey. A amostra da pesquisa correspondeu a 66 organizações, considerando uma população de 109 organizações. Os dados foram coletados por meio de questionário autoadministrado, respondidos pela área de suprimentos de cada organização. Como resultados, constatou-se que o planejamento conjunto e a cultura colaborativa são práticas de colaboração que influenciam no desempenho operacional. Quanto aos fatores de desempenho, a flexibilidade mostrou-se como atributo ausente na indústria metalomecânica. O diagnóstico da influência das práticas de colaboração por segmento industrial apresentou algumas particularidades, na indústria têxtil revelou-se a influência da resolução conjunta de problemas e na indústria metalomecânica destacou-se o planejamento conjunto como variável de impacto no desempenho operacional.

Abstract Collaboration in the supply chain is involved in studies that suggest the relationship between companies in search of mutual benefits and maintenance of a strategic partner to improve the operational performance of organizations. The collaborative practices defined in the literature refer to a collaborative culture, joint planning, joint problem solving, and sharing of resources and information. From this perspective, this article aims to evaluate the influence of collaboration in the supply chain on the operational performance of the medium and large industries of the Textile and Metal-mechanic segment of the Vale do Itajaí (SC). Through questionnaires applied in the supply area in a universe of 109 industries, it was possible to collect data from 66 companies. It was found that joint planning and collaborative culture are collaborative practices that influence operational performance. Regarding the performance factors, flexibility was shown as an absent attribute in the industries: after the analysis of the moderating effect by segment, it was concluded that flexibility was not present only in the Metal-mechanic sector. It was also tried to diagnose the influence of the collaboration practices by industrial segment: in the Textile sector the influence of the joint resolution of problems was revealed and, in the Metal-mechanic sector the joint planning as a variable of impact on the operational performance was highlighted.

Resumo As opções limitadas para reparo ósseo levaram ao desenvolvimento de abrangente pesquisa na área de enxertos aloplásticos e xenogênicos. O objetivo deste estudo foi avaliar o reparo ósseo com dois substitutos ósseos: osso bovino desproteinizado (DBB) e cerâmica fosfática de cálcio bifásica (BCP) em defeito de tamanho crítico. Material e métodos: defeitos críticos de 8 mm foram feitos nos ossos parietais de coelhos (n=12). Os animais foram divididos em três grupos experimentais: sham (defeito preenchido com coágulo sanguíneo), DBB (defeito preenchido com DBB) e BCP (defeito preenchido com BCP). Após os períodos experimentais de 15 e 45 dias, os animais foram sacrificados e submetidos à análise histomorfométrica. Foram avaliadas a área total de defeitos, área de tecidos mineralizados, área de biomateriais e área de tecidos moles. Resultados: maior quantidade de tecido ósseo imaturo e de partículas de biomaterial foram observados no grupo BCP em comparação aos grupos DBB e sham aos 45 dias (p<0,05). Não houve diferença no padrão qualitativo de deposição óssea entre DBB e BCP. Ainda, o grupo sham não apresentou ilhas osteóides ao longo do defeito, apresentando maior quantidade de fibras colágenas em relação aos grupos DBB e BCP. Houve maior quantidade de células inflamatórias no DBB aos 45 dias em comparação aos grupos BCP e sham. Conclusões: BCP e DBB são opções para otimizar o uso de enxertos ósseos na reabilitação de pacientes. Defeitos ósseos tratados com BCP mostraram maior deposição de tecido ósseo aos 45 dias.

Abstract The limited options for bone repair have led to an extensive research of the field and the development of alloplastic and xenogeneic grafts. The purpose of this study was to evaluate bone repair with two bone substitutes: deproteinized bovine bone (DBB) and biphasic calcium phosphate ceramic (BCP) in critical-size defect. A total of 8-mm defects were made in the parietal bones of rabbits (n=12). The animals were divided into three experimental groups: sham (defect filled with a blood clot), DBB (defect filled with DBB), and BCP (defect filled with BCP). After the experimental periods of 15 and 45 days, the animals were euthanized and submitted to histomorphometric analysis. The total defect area, mineralized tissue area, biomaterial area, and soft tissue area were evaluated. A greater amount of immature bone tissue and biomaterial particles were observed in the BCP group compared to DBB and sham at 45 days (p<0.05). There was no difference in the qualitative pattern of bone deposition between DBB and BCP. However, the sham group did not show osteoid islands along with the defect, presenting a greater amount of collagen fibers as well in relation to the DBB and BCP groups. There was a greater number of inflammatory cells in the DBB at 45 days compared to BCP and sham groups. In conclusion, BCP and DBB are options for optimizing the use of bone grafts for maxillofacial rehabilitation. Bone defects treated with BCP showed greater deposition of bone tissue at 45 days.

ABSTRACT The search for productive and stable genotypes is the main goal of breeding programs. The Genotype × Environment interaction strongly influences genotype performance, and makes the selection of new cultivars difficult. One way to take advantage of this interaction is to identify genotypes with high grain yield (GY) and stability in different environments. The objective of this study was to evaluate the consistency of correlation between GY and stability evaluation methods in multi-environment trials and identify which methods are more suitable for selecting genotypes. GY data from 11 soybean (Glycine max [L.] Merr.) cultivars conducted in Value for Cultivation and Use trials in 10 locations in Paraná and Mato Grosso do Sul states, Brazil, in the 2013-2014, 2014-2015, and 2015-2016 crop seasons. A randomized complete block design with three replicates was used. Seven methods were applied to evaluate stability, and Spearman's correlation coefficient was used to compare methods. Positive associations were observed between GY and the harmonic mean of genotypic values (HMGV) across environments and genotype main effect + Genotype × Environment interaction effect by ideal genotype (GGE IG) methodologies, and between GY and the Lin and Binns method modified by Carneiro for general and unfavorable environments. The Eberhart and Russell, additive main effects and multiplicative interaction (AMMI1), and GGE for stability (GGE STA) methods presented no positive associations with GY in any year. Positive associations were found between the Wricke, AMMI1, and Eberhart and Russell methods because they were related to the static stability concept. The HMGV and GGE IG methods can be used together because they are consistently associated with GY and based on the dynamic stability concept.

Infusions of Aspidosperma nitidum (Apocynaceae) wood bark are used to treat fever and malaria in the Amazon Region. Several species of this family are known to possess indole alkaloids and other classes of secondary metabolites, whereas terpenoids, an inositol and the indole alkaloids harmane-3 acid and braznitidumine have been described in A. nitidum . In the present study, extracts from the wood bark, leaves and branches of this species were prepared for assays against malaria parasites and cytotoxicity testing using human hepatoma and normal monkey kidney cells. The wood bark extracts were active against Plasmodium falciparum and showed a low cytotoxicity in vitro, whereas the leaf and branch extracts and the pure alkaloid braznitidumine were inactive. A crude methanol extract was subjected to acid-base fractionation aimed at obtaining alkaloid-rich fractions, which were active at low concentrations against P. falciparum and in mice infected with and sensitive Plasmodium berghei parasites. Our data validate the antimalarial usefulness of A. nitidum wood bark, a remedy that can most likely help to control malaria. However, the molecules responsible for this antimalarial activity have not yet been identified. Considering their high selectivity index, the alkaloid-rich fractions from the plant bark might be useful in the development of new antimalarials.

The effects of different solvents and extraction techniques upon the phytochemical profile and anti-Trichophyton activity of extracts from Piper aduncum leaves were evaluated. Extract done by maceration method with ethanol has higher content of sesquiterpenes and antifungal activity. This extract may be useful as an alternative treatment for dermatophytosis.

Lapachol was chemically modified to obtain its thiosemicarbazone and semicarbazone derivatives. These compounds were tested for antimicrobial activity against several bacteria and fungi by the broth microdilution method. The thiosemicarbazone and semicarbazone derivatives of lapachol exhibited antimicrobial activity against the bacteria Enterococcus faecalis and Staphylococcus aureus with minimal inhibitory concentrations (MICs) of 0.05 and 0.10 µmol/mL, respectively. The thiosemicarbazone and semicarbazone derivatives were also active against the pathogenic yeast Cryptococcus gattii (MICs of 0.10 and 0.20 µmol/mL, respectively). In addition, the lapachol thiosemicarbazone derivative was active against 11 clinical isolates of Paracoccidioides brasiliensis, with MICs ranging from 0.01-0.10 µmol/mL. The lapachol-derived thiosemicarbazone was not cytotoxic to normal cells at the concentrations that were active against fungi and bacteria. We synthesised, for the first time, thiosemicarbazone and semicarbazone derivatives of lapachol. The MICs for the lapachol-derived thiosemicarbazone against S. aureus, E. faecalis, C. gattii and several isolates of P. brasiliensis indicated that this compound has the potential to be developed into novel drugs to treat infections caused these microbes.

Memória organizacional e gestão do conhecimento são temas interligados que têm crescido em importância para pesquisadores e organizações, ao longo dos anos 2000. A literatura aponta as ontologias como importantes métodos que podem ser aplicados para formalizar e representar a memória organizacional. Entretanto, existe um hiato quanto à investigação das pesquisas desenvolvidas na intersecção dessas duas áreas. Este artigo objetiva mapear o perfil e as características das publicações relacionadas à memória organizacional e às ontologias, por meio de técnicas bibliométricas. Foram localizados 39 trabalhos, os quais foram escritos por 85 autores, vinculados a 40 instituições de 18 países diferentes. Para a elaboração desses trabalhos, os autores utilizaram 845 referências e 117 palavras-chave, dentre as quais se destacam Knowledge management, e-Learning e Organizationallearning. Em suma, este estudo possibilita a visualização de padrões e tendências da literatura científica, mostrando quais pesquisas podem ser promissoras no campo de memória organizacional e ontologias.

Organizational Memory and Knowledge management are interconnected themes that have grown up in importance to researchers and organizations over the years 2000. The literature has indicated Ontologies as important methods that can be applied to formalize and represent organizational memory. However, there is a knowledge gap at the intersection of these two areas. This article aimed to map the publications related to organizational memory and ontologies through bibliometric techniques. 39 papers were identified, which were written by 85 authors, linked to 40 institutions from 18 countries. For the elaboration of their work, the authors used 845 references and 117 keywords, among which are highlighted Knowledge Management, e-Learning and Organizational Learning. In short, this work enabled the visualization of patterns and trends of the scientific literature and shows that research may be promising in the field of organizational memory and ontologies.

A comunicação é essencial nas atividades do mundo globalizado, onde conhecimento e tecnologia são a chave do progresso. Dominar outros idiomas nesse cenário é vital para a sustentação das pessoas no exercício de suas atividades. O sistema de ensino de línguas estrangeiras no Brasil, tanto nas escolas públicas quanto em parte das escolas particulares, não oferece condições para que as pessoas adquiram conhecimentos sólidos de língua estrangeira, conforme suas potencialidades e disponibilidades de tempo, sem prejuízo de outras atividades que exerçam no seu cotidiano. O objetivo deste artigo é apresentar uma ferramenta de autoria multimídia para ensino de língua estrangeira, disponível continuamente na Internet, que possa ser acessada de qualquer local e a qualquer momento. A ferramenta será construída baseada em arquitetura multiagente, constituindo um ambiente compartilhado semelhante à cooperação entre pessoas, cumprindo eficazmente a tarefa de ensino. Os idiomas, inicialmente inglês e francês, constarão de três módulos: básico, intermediário e avançado. Após ser disponibilizada na Web, a ferramenta será validada com base na crítica dos usuários por cerca de seis a doze meses e será avaliada periodicamente pelos gestores do programa. A ferramenta propiciará o acesso ao aprendizado eficaz de idiomas estrangeiros a quaisquer interessados, de acordo com suas potencialidades, seus interesses e tempo disponível.

Communication is essential in the activities of a globalized world in which knowledge and technology are the keys to progress. In this scenario, having command of other languages is a vital support for people in their activities. The system for teaching foreign languages in Brazil, both in public schools and in part of the private institutions, fails to offer the basic conditions for people to acquire solid knowledge of a foreign language, according to their potential and time availability, and without affecting the other activities they develop in their daily lives. The objective of the present paper is to introduce a multimedia authorship tool for the teaching of a foreign language, which is continually available on the Internet and therefore accessible from any place at any time. The toll will be built based on a multi-agent architecture constituting a shared environment similar to people's cooperation, fulfilling effectively the task of teaching. The languages, initially English and French, will comprise three modules: basic, intermediate and advanced. After being available on the Web, the tool will be validated by user criticism during a period from six to twelve months, and will be periodically assessed by the managers of the program. The tool will afford access to effective learning of foreign languages to anyone interested, according to their potentiality, interests, and time available.