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Abstract Background: Livedoid vasculopathy (LV) manifests as ulcers and atrophic white scars on the lower extremities. The main known etiopathogenesis is hypercoagulability with thrombus formation, followed by inflammation. Thrombophilia, collagen and myeloproliferative diseases may induce LV, but the idiopathic (primary) form predominates. Bartonella spp. may cause intra-endothelial infection and skin manifestations caused by these bacteria may be diverse, including leukocytoclastic vasculitis and ulcers. Objective: The aim of this study was to investigate the presence of bacteremia by Bartonella spp. in patients with difficult-to-control chronic ulcers diagnosed as primary LV. Methods: Questionnaires and molecular tests (conventional PCR, nested PCR and real-time PCR) were applied and liquid and solid cultures were performed in the blood samples and blood clot of 16 LV patients and 32 healthy volunteers. Results: Bartonella henselae DNA was detected in 25% of LV patients and in 12.5% of control subjects but failed to reach statistically significant differences (p = 0.413). Study limitations: Due to the rarity of primary LV, the number of patients studied was small and there was greater exposure of the control group to risk factors for Bartonella spp. infection. Conclusion: Although there was no statistically significant difference between the groups, the DNA of B. henselae was detected in one of every four patients, which reinforces the need to investigate Bartonella spp. in patients with primary LV.

https://doi.org/10.1016/j.abd.2022.07.007

Nectarine Coated with Biopolymeric Nanocapsules Containing Eugenol to Control Brown Rot
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Jacumazo, Joslaine

; Parchen, Gabriela P.

; Garcia, Meira J. B.

; Santos, Nayana C. S.

; Mio, Louise L. M. De

; Marques, Francisco A.

; Freitas, Rilton A. de

Journal of the Brazilian Chemical Society

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jul 2023, Volume 34 N. 7 Pages 1030 - 1039

Abstract: En | Text: En | PDF: En

Infections in fruits caused by fungi reduce the quantity and quality of food for human consumption, in addition to causing economic losses. In this sense, this study aimed to address the effects of eugenol nanocapsules (NCs) based on chitosan and carboxymethylcellulose in protecting nectarines against Monilinia fructicola, a brown rot agent, a worldwide important disease. NCs were prepared by layer-by-layer (LbL) self-assembly starting from an anionic template and deposition with up to two polymeric layers. The hydrodynamic diameters ranged from 158 nm (nanoemulsion), 360 nm (one polymeric layer) to 398 nm (two polymeric layers). NCs presented, during the in vitro release, the release of eugenol following a first order process. In addition to being in the region of stability (zeta potential ca. |30| mV), the capsules showed good adhesion to the nectarine surface. In relation to brown rot, the eugenol NCs with chitosan proved to be the best formulation compared to nanoemulsion and NCs with two polymeric layers for its control, increasing the probability that the fruits remain without symptoms, even after 7 days. Therefore, this study demonstrated that chitosan NCs containing eugenol could be an alternative to preserve fruit for longer periods in post-harvest.

https://doi.org/10.21577/0103-5053.20230018

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
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Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

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2023, Volume 71 Suppl. 3 elocation e23022

Abstract: En | Text: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development.

https://doi.org/10.1590/2675-2824071.22072dlm

Effective recommendations towards healthy routines to preserve mental health during the COVID-19 pandemic
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Pilz, Luísa K.

; Couto Pereira, Natividade S.

; Francisco, Ana Paula

; Carissimi, Alicia

; Constantino, Débora B.

; Caus, Letícia B.

; Abreu, Ana Carolina O.

; Amando, Guilherme R.

; Bonatto, Fernanda S.

; Carvalho, Paula V.V.

; Cipolla-Neto, José

; Harb, Ana

; Lazzarotto, Gabriela

; Marafiga, Joseane Righes

; Minuzzi, Luciano

; Montagner, Francisco

; Nishino, Fernanda A.

; Oliveira, Melissa A.B.

; dos Santos, Bruno G.T.

; Steibel, Eduardo G.

; Tavares, Patrice S.

; Tonon, André C.

; Xavier, Nicóli B.

; Zanona, Querusche Klippel

; Amaral, Fernanda G.

; Calcagnotto, Maria Elisa

; Frey, Benicio N.

; Hidalgo, Maria Paz

; Idiart, Marco

; Russomano, Thais

Brazilian Journal of Psychiatry

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apr 2022, Volume 44 N. 2 Pages 136 - 146

Abstract: En | Text: En | PDF: En

Objective: To assess the adherence to a set of evidence-based recommendations to support mental health during the coronavirus disease 2019 (COVID-19) pandemic and its association with depressive and anxiety symptoms. Methods: A team of health workers and researchers prepared the recommendations, formatted into three volumes (1: COVID-19 prevention; 2: Healthy habits; 3: Biological clock and sleep). Participants were randomized to receive only Volume 1 (control), Volumes 1 and 2, Volumes 1 and 3, or all volumes. We used a convenience sample of Portuguese-speaking participants over age 18 years. An online survey consisting of sociodemographic and behavioral questionnaires and mental health instruments (Patient Health Questionnaire-9 [PHQ-9] and Generalized Anxiety Disorder-7 [GAD-7]) was administered. At 14 and 28 days later, participants were invited to complete follow-up surveys, which also included questions regarding adherence to the recommendations. A total of 409 participants completed the study – mostly young adult women holding university degrees. Results: The set of recommendations contained in Volumes 2 and 3 was effective in protecting mental health, as suggested by significant associations of adherence with PHQ-9 and GAD-7 scores (reflecting anxiety and depression symptoms, respectively). Conclusion: The recommendations developed in this study could be useful to prevent negative mental health effects in the context of the pandemic and beyond.

https://doi.org/10.1590/1516-4446-2021-2109

Guía de práctica clínica de la Sociedad Interamericana de Cardiología sobre prevención primaria de enfermedad cardiovascular en la mujer
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Sueldo, Mildren A. del

; Rivera, María A. Mendonça

; Sánchez-Zambrano, Martha B.

; Zilberman, Judith

; Múnera-Echeverri, Ana G.

; Paniagua, María

; Campos-Alcántara, Lourdes

; Almonte, Claudia

; Paix-Gonzales, Amalia

; Anchique-Santos, Claudia V.

; Coronel, Claudine J.

; Castillo, Gabriela

; Parra-Machuca, María G.

; Duro, Ivanna

; Varletta, Paola

; Delgado, Patricia

; Volberg, Verónica I.

; Puente-Barragán, Adriana C.

; Rodríguez, Adriana

; Rotta-Rotta, Aida

; Fernández, Anabela

; Izeta-Gutiérrez, Ana C.

; Ancona-Vadillo, Ana E.

; Aquieri, Analía

; Corrales, Andrea

; Simeone, Andrea

; Rubilar, Bibiana

; Artucio, Carolina

; Pimentel-Fernández, Carolina

; Marques-Santos, Celi

; Saldarriaga, Clara

; Chávez, Christian

; Cáceres, Cristina

; Ibarrola, Dahiana

; Barranco, Daniela

; Muñoz-Ortiz, Edison

; Ruiz-Gastelum, Edith D.

; Bianco, Eduardo

; Murguía, Elena

; Soto, Enrique

; Rodríguez-Caballero, Fabiola

; Otiniano-Costa, Fanny

; Valentino, Giovanna

; Rodríguez-Cermeño, Iris B.

; Rivera, Ivan R.

; Gándara-Ricardo, Jairo A.

; Velásquez-Penagos, Jesús A.

; Torales, Judith

; Scavenius, Karina

; Dueñas-Criado, Karen

; García, Laura

; Roballo, Laura

; Kazelian, Lucía R.

; Coussirat-Liendo, Macarena

; Costa-Almeida, María C.

; Drever, Mariana

; Lujambio, Mariela

; Castro, Marildes L.

; Rodríguez-Sifuentes, Maritza

; Acevedo, Mónica

; Giambruno, Mónica

; Ramírez, Mónica

; Gómez, Nancy

; Gutiérrez-Castillo, Narcisa

; Greatty, Onelia

; Harwicz, Paola

; Notaro, Patricia

; Falcón, Rocío

; López, Rosario

; Montefilpo, Sady

; Ramírez-Flores, Sara

; Verdugo, Silvina

; Murguía, Soledad

; Constantini, Sonia

; Vieira, Thais C.

; Michelis, Virginia

; Serra, César M.

Archivos de cardiología de México

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2022, Volume 92 Suppl. 2 Pages 1 - 68

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.24875/acm.22000071 450 downloads

In vitro Photoprotective Evaluation and Development of Novel Nanoemulsion with Chromone Derivative
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Antunes, Amanda S.

; Gouveia, Ana Paula

; Diogo, Gabriela M.

; Taylor, Jason G.

; Sousa, Lucas R. D.

; Amparo, Tatiane R.

; Perasoli, Fernanda B.

; Santos, Orlando D. H. dos

; Cazati, Thiago

; Vieira, Paula M. A.

; Penido, Ricardo G.

; Santos, Viviane M. R. dos

Journal of the Brazilian Chemical Society

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sep 2021, Volume 32 N. 9 Pages 1813 - 1821

Abstract: En | Text: En | PDF: En

Chromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass spectrometry, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The in vitro solar protection factor (SPF) was determined by the Mansur method and cytotoxicity was evaluated using the sulforhodamine B assay. Two of the chromones synthesized demonstrated suitable SPF values and displayed no cytotoxic effect towards MRC-5 human fibroblasts at the tested concentrations, indicating great potential for future in vivo assays and clinical trials. Finally, the lead compound was incorporated into a nanoemulsion. Nanoemulsions showed high droplet size homogeneity and excellent stability. Chromones bearing methoxy substituents were found to be the most promising compounds with ideal photoprotective properties desirable for utilization and incorporation in sunscreen formulations.

https://doi.org/10.21577/0103-5053.20210072 24 downloads

O USO DE SOFTWARES LIVRES EM AULA PRáTICA SOBRE FILTROS MOLECULARES DE BIODISPONIBILIDADE ORAL DE FáRMACOS
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Rodrigues, Gabriela dos Santos

; Avelino, Júnior A

; Siqueira, Ariane L. N.

; Ramos, Luciana F. P.

; Santos, Gabriela B. dos

Química Nova

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aug 2021, Volume 44 N. 8 Pages 1036 - 1044

Abstract: Pt | Text: Pt | PDF: Pt

THE USE OF FREE SOFTWARES IN PRACTICAL CLASS ABOUT THE MOLECULAR FILTERS OF ORAL BIOAVAILABILITY OF DRUGS. The study of the physical chemical properties to predict the oral bioavailability of drugs is a widely tool used by researches on the Pharmaceutical and Medicinal Chemistry field. Even though it is a deeply studied subject, it is a complex task to teach to pharmacy students. Lipinski stablished that molecular weight, lipophilicity, hydrogen bond donors and acceptors are of great importance for oral bioavailability. In addition, Veber and Lovering added other properties, such as number of rotatable bonds, fraction of sp3 hybridized carbon and polar surface area that amplified the Lipinski Rule of 5. In this sense, the access to chemical databases and the comprehension of this information is an important task to undergraduate and graduate students. Thus, this work aims a new teaching methodology that values the critical interpretation of data and that favors the students comprehension beyond stablished rules.

https://doi.org/10.21577/0100-4042.20170739 61 downloads

Prevalence of hepatitis A in the capitals of the States of North, Southeast and South regions of Brazil: decrease in prevalence and some consequences
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Pereira, Leila M. M. B.

; Stein, Airton T.

; Figueiredo, Gerusa Maria

; Coral, Gabriela Perdomo

; Montarroyos, Ulisses R.

; Cardoso, Maria Regina Alves

; Braga, Maria Cynthia

; Moreira, Regina Celia

; Santos, Alex A. dos

; Ximenes, Ricardo Alencar

Revista do Instituto de Medicina Tropical de São Paulo

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2021, Volume 63 elocation e34

Abstract: En | Text: En | PDF: En

ABSTRACT Hepatitis A virus (HAV) infection has been considered one of the leading causes of acute hepatitis. The aim of the present study was to estimate the prevalence of HAV among children and adolescents in a population-based study in the capitals of the States of the North, Southeast and South of Brazil and identify predictive factors for the infection. A multi-stage sampling was used to select subjects aged between 5-9 and 10-19 years. Individual and household levels aside from the level of variables in the areas were collected. The outcome was the total IgG antibodies to HAV levels detected using a commercial Enzyme Immuno Assay (EIA). The associations between HAV and the independent variables were assessed using the odds ratio. A multilevel analysis was performed by GLLAMM using the Stata software. The prevalence of HAV infection in the 5-9 and 10-19 age groups was 28.7% and 67.5%, respectively for the North, 20.6% and 37.7%, for the Southeast and 18.9% and 34.5% for the South Region. The prevalence of HAV increased according to age in all sites. Variables related to education at the individual level (North and South), family and area level (South and Southeast) and family income level (Southeast and South) were independently associated with HAV infection. This emphasizes the need for individualized strategies to prevent the infection.

https://doi.org/10.1590/s1678-9946202163034 358 downloads

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3511

Abstract: En | Text: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

10.

Clinical usefulness of tomographic standards for COVID-19 pneumonia diagnosis: Experience from a Brazilian reference center
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Grando, Rafael D.

; Brentano, Vicente B.

; Zanardo, Ana P.

; Hertz, Felipe T.

; Anflor Júnior, Luís C.

; Santos, Jônatas F. Prietto dos

; Galvão, Gabriela S.

; Zavascki, Alexandre P.

; Gazzana, Marcelo B.

Brazilian Journal of Infectious Diseases

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dec 2020, Volume 24 N. 6 Pages 524 - 533

Abstract: En | Text: En | PDF: En

ABSTRACT Background: COVID-19 is a new disease and the most common complication is pneumonia. The Radiological Society of North America (RSNA) proposed an expert consensus for imaging classification for COVID-19 pneumonia. Objective: To evaluate sensitivity, specificity, accuracy, and reproducibility of chest CT standards in the beginning of the Brazilian COVID-19 outbreak. Methods: Cross-sectional study performed from March 1st to April 14th, 2020. Patients with suspected COVID-19 pneumonia submitted to RT-PCR test and chest computed tomography (CT) were included. Two thoracic radiologists blinded for RT-PCR and clinical and laboratory results classified every patient scan according to the RSNA expert consensus. A third thoracic radiologist also evaluated in case of discordance, and consensus was reached among the three radiologists. A typical appearance was considered a positive chest CT for COVID-19 pneumonia. Sensitivity, specificity, positive and negative predictive values were calculated. Cohen's kappa coefficient was used to evaluate intra- and inter-rater agreements. Results: A total of 159 patients were included (mean age 57.9 ± 18.0 years; 88 [55.3%] males): 86 (54.1%) COVID-19 and 73 (45.9%) non-COVID-19 patients. Eighty (50.3%) patients had a positive CT for COVID-19 pneumonia. Sensitivity and specificity of typical appearance were 88.3% (95%CI, 79.9-93.5) and 94.5% (95%CI, 86.7-97.8), respectively. Intra- and inter-rater agreement were assessed (Cohen's kappa = 0.924, P= 0.06; Cohen's kappa=0.772, P= 0.05, respectively). Conclusion: Chest CT categorical classification of COVID-19 findings is reproducible and demonstrates high level of agreement with clinical and RT-PCR diagnosis of COVID-19. In RT-PCR scarcity scenarios or in equivocal cases, it may be useful for attending physicians in the evaluation of suspected COVID-19 pneumonia patients attended at the emergency unit.

https://doi.org/10.1016/j.bjid.2020.10.002 376 downloads

11.

Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status
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Soares, Marcos

; Santos, Analu B. dos

; Weich, Tainara M.

; Mânica, Gabriela Gomes

; Homem de Bittencourt Junior, Paulo Ivo

; Ludwig, Mirna Stela

; Heck, Thiago Gomes

Brazilian Journal of Otorhinolaryngology

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dec 2020, Volume 86 N. 6 Pages 703 - 710

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A proteína de choque térmico de 72 kDa, HSP72 localizada intracelularmente, tem papéis citoprotetores e anti-inflamatórios cocleares na orelha interna durante situações de ruído estressantes. A expressão dessa proteína pode ser potencializada pela suplementação com dipeptídeo de alanil-glutamina. Por outro lado, essas proteínas atuam como sinais pró-inflamatórios no meio extracelular. Objetivo: Investigar se a perda auditiva induzida por ruído promove alterações tanto das proteínas HSP72 intracelulares quanto extracelulares na resposta de choque térmico e se a suplementação com alanil-glutamina pode modificar a resposta de choque térmico e evitar a perda auditiva. Método: Ratos Wistar fêmeas, com 90 dias de idade (n = 32), foram divididos aleatoriamente em quatro grupos: controle, perda auditiva induzida por ruído, tratados com alanil-glutamina e perda auditiva induzida por ruído mais alanil-glutamina. Os potenciais evocados auditivos do tronco encefálico foram avaliados antes da exposição ao ruído (124 dB NPS por 2 h) e 14 dias após. A cóclea, o complexo nuclear coclear e amostras de plasma foram coletadas para mensuração de HSP72 intra e extracelular com um kit Elisa de alta sensibilidade. Resultados: Houve um aumento nos níveis de HSP72 intra e extracelular no grupo perda auditiva induzida por ruído, que foi minimizado pelo tratamento com alanil-glutamina. Além disso, o índice H das HSP72 (razão HSP72 extracelular/HSP72intracelular plasma/cóclea) aumentou no grupo perda auditiva induzida por ruído, mas foi limitado pelo tratamento com alanil-glutamina, embora o alanil-glutamina não tenha efeito no limiar auditivo. Conclusões: Nossos dados indicam que o dano coclear induzido pela exposição ao ruído é acompanhado por marcadores da resposta de choque térmico locais e sistêmicos. Além disso, alanil-glutamina reduziu os marcadores de estresse, mesmo não tendo efeito sobre a perda auditiva induzida por ruído. Finalmente, os níveis plasmáticos de proteínas de choque térmico de 72 kDa podem ser usados como biomarcador do estresse auditivo, após a exposição ao ruído.

Abstract Introduction: The 72 kDa heat shock protein, HSP72, located intracellularly provides cochlear cytoprotective and anti-inflammatory roles in the inner ear during stressful noise challenges. The expression of intracellular HSP72 (iHSP72) can be potentiated by alanyl-glutamine dipeptide supplementation. Conversely, these proteins act as pro-inflammatory signals in the extracellular milieu (eHSP72). Objective: We explore whether noise-induced hearing loss promotes both intracellular and extracellular HSP72 heat shock response alterations, and if alanyl-glutamine dipeptide supplementation could modify heat shock response and prevent hearing loss. Methods: Female 90 day-old Wistar rats (n = 32) were randomly divided into four groups: control, noise-induced hearing loss, treated with alanyl-glutamine dipeptide and noise-induced hearing loss plus alanyl-glutamine dipeptide. Auditory brainstem responses were evaluated before noise exposure (124 dB SPL for 2 h) and 14 days after. Cochlea, nuclear cochlear complex and plasma samples were collected for the measurement of intracellular HSP72 and extracellular HSP72 by a high-sensitivity ELISA kit. Results: We found an increase in both iHSP72 and eHSP72 levels in the noise-induced hearing loss group, which was alleviated by alanyl-glutamine dipeptide treatment. Furthermore, H-index of HSP72 (plasma/cochlea eHSP72/iHSP72 ratio) was increased in the noise-induced hearing loss group, but prevented by alanyl-glutamine dipeptide treatment, although alanyl-glutamine dipeptide had no effect on auditory threshold. Conclusions: Our data indicates that cochlear damage induced by noise exposure is accompanied by local and systemic heat shock response markers. Also, alanyl-glutamine reduced stress markers even though it had no effect on noise-induced hearing loss. Finally, plasma levels of 72 kDa heat shock proteins can be used as a biomarker of auditory stress after noise exposure.

https://doi.org/10.1016/j.bjorl.2019.04.012 498 downloads

12.

Synergic effect of simvastatin in combination with amphotericin B against environmental strains of Cryptococcus neoformans from northeastern Brazil: a prospective experimental study
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Silva, Tássio Henrique Sousa

; Araújo, Claudiane Vansoski

; Santos, Khelvin Myner da Costa

; Alves, Nathanael dos Santos

; Gomes, Thayse Haylene Soares

; Silva, Andressa Kelly Ferreira e

; Silva, Nayra Cristina Lira dos Santos

; Damasceno Júnior, Evandro César Bezerra

; Carvalho, Andressa Maria Aguiar de

; Mendes, Maria Gabriela Araújo

; Caminha, Henrique Barros

; Daboit, Tatiane Caroline

; Ferreira, Thatiana Bragine

; Andrade-Silva, Leonardo Eurípedes

; Silva-Vergara, Mario León

; Ferreira-Paim, Kennio

; Fonseca, Fernanda Machado

Sao Paulo Medical Journal

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feb 2020, Volume 138 N. 1 Pages 40 - 46

Abstract: En | Text: En | PDF: En

BACKGROUND: Statins are used as cholesterol-lowering drugs and may also have direct antimicrobial effects. OBJECTIVE: To evaluate synergic interactions between simvastatin and both amphotericin B and fluconazole, against environmental strains of Cryptococcus neoformans isolated from captive birds’ droppings. DESIGNAND SETTING: Experimental study conducted at Federal University of Piauí, Parnaíba, in collaboration with Federal University of Triângulo Mineiro, Uberaba, Brazil. METHODS: Statin susceptibility tests of Cryptococcus neoformans samples were performed as prescribed in standards. Interactions of simvastatin with amphotericin and fluconazole were evaluated using the checkerboard microdilution method. Presence of these interactions was quantitatively detected through determining the fractional inhibitory concentration index (FICI). RESULTS: Isolates of Cryptococcus neoformans were obtained from 30 of the 206 samples of dry bird excreta (14.5%) that were collected from pet shops and houses. Ten isolates were selected for susceptibility tests. All of them were susceptible to amphotericin and fluconazole. All presented minimum inhibitory concentration (MIC) > 128 µg/ml and, thus, were resistant in vitro to simvastatin. An in vitro synergic effect was shown through combined testing of amphotericin B and simvastatin, such that six isolates (60%) presented FICI < 0.500. Two isolates showed considerable reductions in MIC, from 1 µg/ml to 0.250 µg/ml. No synergic effect was observed through combining fluconazole and simvastatin. CONCLUSION: These results demonstrate that simvastatin should be considered to be a therapeutic alternative, capable of potentiating the action of amphotericin B. However, further studies are necessary to clarify the real effect of simvastatin as an antifungal agent.

https://doi.org/10.1590/1516-3180.2019.0107.r2.16092019 584 downloads

13.

“DIVING” INTO THE MEANINGS AND REVEALING CONCEPTIONS OF BEING A PROFESSOR IN MANAGEMENT
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SANTOS, GABRIELA T.

; SILVA, ANIELSON B.

RAM. Revista de Administração Mackenzie

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2019, Volume 20 N. 5 elocation eRAMG190144

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: O objetivo deste estudo é identificar as concepções do ser professor em Administração. As reflexões teóricas que definiram a compreensão do fenômeno estão associadas ao conhecimento docente, à formação de professores e às concepções do ser professor. Originalidade/valor: Os resultados deste estudo revelam que as concepções do ser professor refletem sobre a prática docente e no desenvolvimento dos saberes concebidos a partir das ideologias dominantes do campo, dos contextos socioeconômicos e dos contextos políticos atuais. Este estudo contribui para o processo de formação do professor em Administração. Design/metodologia/abordagem: Trata-se de um estudo qualitativo que utiliza a fenomenografia como método para compreender, a partir do espaço de resultados, o significado das concepções identificadas por meio de entrevistas realizadas com 20 professores atuantes na pós-graduação de Administração de programas no Brasil por mais de dez anos. Resultados: Os resultados da análise dos dados permitiram a identificação de quatro concepções do ser professor: 1. um profissional que realiza o trabalho como qualquer outro; 2. um educador que atua como mediador do conhecimento; 3. um autor de processo educacional; e 4. um agente que transforma as pessoas e a si mesmo.

ABSTRACT Purpose: The objective of this study is to identify conceptions of being a professor in Management. The theoretical reflections that have defined the understanding of the phenomenon are associated with teaching knowledge, professor training and conceptions of being a professor. Originality/value: The results of this study reveal that conceptions of being a professor reflect the practice of teaching and the development of knowledge perceived from the field's dominant ideologies, the socio-economic background, and the current political contexts. This study contributes to the process of professors' Management training. Design/methodology/approach: This is a qualitative study and uses phenomenography as a method to understand, based on outcome space, the meaning of conceptions identified through interviews conducted with 20 professors working in undergraduate and graduate Management programs in Brazil for more than ten years. Findings: The results of the data analysis allow the identification of four conceptions of being a professor: 1. a professional who performs the job like any other; 2. an educator who acts as a knowledge mediator; 3. an author of educational process; and 4. an agent who transforms people and him/herself.

https://doi.org/10.1590/1678-6971/eramg190144 954 downloads

14.

Antiproliferative potential of solidagenone isolated of Solidago chilensis
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Gomes, Denise B.

; Zanchet, Barbara

; Locateli, Gelvani

; Benvenutti, Régis C.

; Vechia, Cristian A. Dalla

; Schönell, Amanda P.

; Diel, Kriptsan A.P.

; Zilli, Gabriela A.L.

; Miorando, Daniela

; Ernetti, Jackeline

; Oliveira, Bianca

; Zanotelli, Patrícia

; Santos, Maria F.C.

; Barisson, Andersson

; Banzato, Thais P.

; Ruiz, Ana L.T.G.

; Carvalho, João E.

; Cechinel Filho, Valdir

; García, Pablo A.G.

; Feliciano, Arturo San

; Roman Junior, Walter A.

Revista Brasileira de Farmacognosia

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dec 2018, Volume 28 N. 6 Pages 703 - 709

Abstract: En | Text: En | PDF: En

ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis.

https://doi.org/10.1016/j.bjp.2018.09.001 766 downloads

15.

Accidental poisoning by castor bean (Ricinus communis) cake in horses
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Montão, Daniele P.

; Araújo, Bruna T.S.

; Santos, Tiago F.S.

; Lima, Danielli B.

; Gonçalves, Fábio T.

; Duarte, Marcos D.

; Riet-Correa, Gabriela

; Bezerra Júnior, Pedro S.

Pesquisa Veterinária Brasileira

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oct 2018, Volume 38 N. 10 Pages 1923 - 1928

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Ricinus communis é um arbusto da família Euphorbiaceae conhecido popularmente como “mamona” ou “carrapateira”. A planta é considerada oleaginosa e suas sementes têm sido utilizadas, principalmente, na produção de biodiesel. A extração do óleo pode ser mecânica ou com solventes, gerando, como subprodutos, a torta de mamona e a farinha de mamona, respectivamente. A ingestão acidental desses subprodutos pode causar intoxicação em animais e humanos, caracterizada por sinais digestivos devido a toxalbumina ricina. A toxidez das sementes varia entre as espécies animais, em equinos a dose letal de sementes é de 0,1g/kg de peso vivo. Há vasta literatura sobre a intoxicação por R. communis em diferentes espécies animais e humanos. Em relação aos equinos os relatos são escassos e com poucas informações sobre os aspectos patológicos da intoxicação. Assim, os objetivos do presente estudo foram descrever os aspectos epidemiológicos, clínicos e patológicos observados em um surto de intoxicação acidental por torta de mamona em equinos. Os equinos eram suplementados com torta de dendê (Elaeis guianeesis), no entanto, na compra de uma nova partida, houve um erro no pedido sendo solicitada torta de mamona. Os quatro equinos que receberam a torta de mamona apresentaram sinais clínicos indicativos de cólica, que iniciaram cerca de 21 horas após administração. Três destes morreram, com evolução clínica 2 a 4,5 horas, o outro animal foi tratado com fluidoterapia intravenosa, antibioticoterapia e anti-inflamatório não esteroidal, recuperando-se em 5 dias. Na necropsia de dois destes equinos, as principais lesões foram encontradas no intestino delgado, sendo observadas mucosas com avermelhamento acentuado e recobertas por fina camada de material amarelado fibrinoso. No lúmen intestinal, havia grande quantidade de líquido sanguinolento. O estômago estava repleto de grumos escuros semelhantes às sementes trituradas da mamona em meio ao conteúdo. As adrenais de ambos equinos apresentavam congestão e hemorragias corticais. Na microscopia, a principal lesão foi uma enteropatia fibrino-necrótica, aguda, difusa e acentuada, afetando com maior intensidade o jejuno. O diagnóstico de intoxicação por torta de mamona foi baseado na evidência circunstancial de consumo do subproduto, sendo corroborado pelos aspectos clínicos e patológicos. Os resultados indicam que a torta de mamona vendida para fertilização do solo é extremamente tóxica quando ingerida, havendo a necessidade de detoxicação ou rotulagem adequada informando sobre a sua toxicidade.

Abstract: Ricinus communis is a shrub of the family Euphorbiaceae popularly known in Brazil as “mamona” or “carrapateira”. It is an oleaginous plant whose seeds have been used mainly in biodiesel production. Plant seed oil can be extracted mechanically or using solvents, generating castor bean cake and castor bean meal as by-products, respectively. Accidental ingestion of these by-products can cause poisoning in animals and humans, characterized by digestive signs resulting from the presence of a toxalbumin called ricin. Seed toxicity varies among animal species; in horses, the lethal dose of seeds is 0.1 g/kg of body weight. The literature presents plenty of studies addressing poisoning by R. communis in different animal species and in humans; however, reports are scarce and little information is available on the pathological aspects of poisoning regarding equines. Therefore, the present study aimed to describe the epidemiological, clinical and pathological aspects observed in an outbreak of accidental poisoning with castor bean cake in horses. The equines were supplemented with palm kernel (Elaeis guianeesis) cake; however, in the purchase of a new batch, there was an error in the order, and castor bean cake was requested instead. Four horses that received castor bean cake presented clinical signs indicative of colic, which started about 21 hours after administration. Three of these horses died, with clinical evolution from 2 to 4.5 hours; the other animal was treated with intravenous fluid and antibiotic therapy and non-steroidal anti-inflammatory drugs and recovered after five days. In the necropsy of two of these horses, the main lesions were found in the small intestine, where mucosae with pronounced redness and covered with a thin layer of yellow fibrous material were observed. In the intestinal lumen, there was a large amount of bloody liquid. The stomach was full, and dark lumps similar to crushed castor bean seeds were observed in the contents. The adrenal glands of both horses presented congestion and hemorrhage in the cortex. In microscopy, the main lesion was an acute, diffuse and accentuated fibrin-necrotic enteropathy affecting the jejunum. The diagnosis of castor bean cake poisoning was based on the circumstantial evidence of by-product consumption supported by clinical and pathological aspects. The results indicate that castor bean cake commercially available as fertilizer is extremely toxic when ingested, and there is a need for appropriate detoxification or labeling informing of its toxicity.

https://doi.org/10.1590/1678-5150-pvb-5887 2999 downloads

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