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Abstract Objectives This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.

https://doi.org/10.1016/j.clinsp.2022.100013

Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action
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Nunes, Débora Cristina de Oliveira Silva

; Costa, Mônica Soares

; Bispo-da-Silva, Luiz Borges

; Ferro, Eloísa Amália Vieira

; Zóia, Mariana Alves Pereira

; Goulart, Luiz Ricardo

; Rodrigues, Renata Santos

; Rodrigues, Veridiana de Melo

; Yoneyama, Kelly Aparecida Geraldo

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e210157

Abstract: En | Text: En | PDF: En

BACKGROUND Leishmania parasites cause leishmaniasis that range from self-limiting cutaneous lesions to more serious forms of the disease. The search for potential drug targets focusing on biochemical and metabolic pathways revealed the sterol biosynthesis inhibitors (SBIs) as a promising approach. In this class of inhibitors is found ketoconazole, a classical inhibitor of 14α-methysterol 14-demethylase. OBJECTIVE The present study aimed to better understand the biological response of Leishmania (Leishmania) amazonensis promastigotes at the cellular level after ketoconazole treatment. METHODS Herein, techniques, such as fluorimetry, flow cytometry, fluorescence microscopy, electron and scanning microscopy were used to investigate the cellular structures and to identify organelles affected by ketoconazole treatment. FINDINGS The study demonstrated, for the first time, the effect of ketoconazole on mitochondrion functioning and its probable relationship to cell cycle and death on L. (L.) amazonensis promastigotes (IFLA/BR/67/PH8 strain). MAIN CONCLUSIONS Ketoconazole-induced mitochondrial damages led to hyperpolarisation of this single organelle and autophagic vacuoles formation, as a parasite survival strategy. These damages did not reflect directly on the parasite cell cycle, but drove the parasites to death, making them susceptible to ketoconazole treatment in in vitro models.

https://doi.org/10.1590/0074-02760210157

Repercussões da infodemia associada ao COVID-19 na saúde mental do idoso no Brasil
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Bezerra Cavalcante, Ricardo

; da Costa Carbogim, Fabio

; Fávero Bulgarelli, Alexandre

; Mello dos Santos, Camila

; Queiroz Ribeiro, Andréia

; Carvalho Pinto, Ione

; Machado Zacharias, Fabiana Costa

; Aparecida Fabriz, Luciana

; Moura de Oliveira, Deíse

; Toledo de Mendonça, Erica

; Ricardo Moreira, Tiago

; Miranda Machado, Richardson

; Ribeiro Bitencourt, Graziele

; Alfradique de Souza, Priscilla

; Fereira Santana, Rosimere

; Cabreira Panitz Cruz, Gylce Eloisa

; Rezende Freitas, Eduarda

; Salmazo da Silva, Henrique

; Viana Cruz, Fabiana

; Silva Fhon, Jack Roberto

; Shizuê Kitamura, Elisa

; Gonçalves Leite, Isabel Cristina

; Rodrigues Braz, Patricia

; Consolação dos Santos, Regina

; Prado Rocha, Flávia

; Aparecida Silva, Eveline

; Barreiros Tavares, Thais

; Duarte Martins, Jerusa Gonçalves

; Alves de Araújo Püschel, Vilanice

Revista Cubana de Información en Ciencias de la Salud

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2022, Volume 33 elocation e1871

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: O fenômeno denominado infodemia refere-se ao aumento do volume informacional sobre um tema em específico, que se multiplica rapidamente em um curto período de tempo, e tem-se destacado frente ao contexto da crise sanitária desencadeada pela pandemia de COVID-19. O excesso de informações pode suscitar sentimentos de medo, ansiedade, estresse e outras condições de sofrimento mental. O estudo tem como objetivo descrever o perfil de exposição a informações sobre COVID-19 e suas repercussões na saúde mental de idosos brasileiros. Trata-se de um estudo transversal realizado com 1924 idosos brasileiros. Coletaram-se dados por meio de web-based survey enviada aos idosos por redes sociais e e-mail, no período de julho a outubro de 2020. Os resultados da análise descritiva dos dados demonstram que a maioria dos idosos apresentou idade entre 60 e 69 anos (69,02%), é do sexo feminino (71,26%), casados (53,79%) e de cor branca (75,57%). Cerca de 21,67% (n = 417) concluíram a graduação, 19,75% (380) concluíram especialização e 16,63% (320) concluíram mestrado ou doutorado. Foram reportados como fontes frequentes de exposição às notícias ou informações sobre a COVID-19, a televisão 862 (44,80%) e as redes sociais 651 (33,84%). Os participantes assinalaram que a televisão (46,47%; n = 872), as redes sociais (30,81%; n = 575) e o rádio (14,48%; 251) os afetavam psicológica e/ou fisicamente. Receber notícias falsas sobre a COVID-19 pela televisão (n = 482; 19,8%) e pelas redes sociais (n = 415; 21,5%) repercutiu, principalmente, estresse e medo. As informações disseminadas contribuem para conscientização, mas, também, afetam física e/ou psicologicamente muitos idosos, principalmente gerando medo e estresse.

ABSTRACT The phenomenon called infodemia refers to the increase in the volume of information on a specific topic, which multiplies rapidly in a short period of time, and has stood out in the context of the health crisis triggered by the COVID-19 pandemic. Too much information can trigger feelings of fear, anxiety, stress, and other conditions of mental distress. The study aims to describe the profile of exposure to information about COVID-19 and its repercussions on the mental health of elderly Brazilians. This is a cross-sectional study carried out with 1924 elderly Brazilians. Data were collected through a web-based survey sent to the elderly via social networks and email, from July to October 2020. The results of the descriptive analysis of the data show that most of the elderly were aged between 60 and 69 years (69.02%), female (71.26%), married (53.79%) and white (75.57%). About 21.67% (n = 417) concluded their graduation, 19.75% (380) concluded their specialization and 16.63% (320) concluded their master's or doctoral degrees. Television 862 (44.80%) and social networks 651 (33.84%) were reported as frequent sources of exposure to news or information about COVID-19. Participants indicated that television (46.47%; n = 872), social networks (30.81%; n = 575) and radio (14.48%; 251) affected them psychologically and/or physically. Receiving fake news about COVID-19 on television (n = 482; 19.8%) and on social media (n = 415; 21.5%) mainly resulted in stress and fear. The disseminated information contributes to awareness, but also affects physically and/or psychologically many elderly people, mainly generating fear and stress.

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Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil
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Pileggi, Gecilmara Salviato

; Ferreira, Gilda Aparecida

; Gomides Reis, Ana Paula Monteiro

; Reis Neto, Edgard Torres

; Abreu, Mirhelen Mendes

; Albuquerque, Cleandro Pires

; Araújo, Nafice Costa

; Bacchiega, Ana Beatriz

; Bianchi, Dante Valdetaro

; Bica, Blanca

; Bonfa, Eloisa Duarte

; Borba, Eduardo Ferreira

; Brito, Danielle Christinne Soares Egypto

; Duarte, Ângela Luzia Branco Pinto

; Santo, Rafaela Cavalheiro Espírito

; Fernandes, Paula Reale

; Guimarães, Mariana Peixoto

; Gomes, Kirla Wagner Poti

; Kakehasi, Adriana Maria

; Klumb, Evandro Mendes

; Lanna, Cristina Costa Duarte

; Marques, Claudia Diniz Lopes

; Monticielo, Odirlei André

; Mota, Licia Maria Henrique

; Munhoz, Gabriela Araújo

; Paiva, Eduardo Santos

; Pereira, Helena Lucia Alves

; Provenza, José Roberto

; Ribeiro, Sandra Lucia Euzébio

; Rocha Junior, Laurindo Ferreira

; Sampaio, Camila Santana Justo Cintra

; Sampaio, Vanderson Souza

; Sato, Emília Inoue

; Skare, Thelma

; de Souza, Viviane Angelina

; Valim, Valeria

; Lacerda, Marcus Vinícius Guimarães

; Xavier, Ricardo Machado

; Pinheiro, Marcelo Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 60

Abstract: En | Text: En | PDF: En

Abstract Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS-CoV-2 outbreak. Our aim was to compare the occurrence of COVID-19 between rheumatic disease patients on hydroxychloroquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil. Methods: This baseline cross-sectional analysis is part of a 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. All information regarding COVID-19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web-based platform using telephone calls from physicians and medical students. COVID-19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann-Whitney, Chi-square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward-stepwise method for the presence of COVID-19. Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total, 1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk factor significantly associated with a COVID-19 diagnosis was lung disease (OR 1.63; 95% CI 1.03-2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19-6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31-3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46-0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID-19 to household cohabitants, suggesting a lack of any protective role against SARS-CoV-2 infection. Trial registration Brazilian Registry of Clinical Trials (ReBEC; RBR - 9KTWX6).

https://doi.org/10.1186/s42358-021-00217-0 22 downloads

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Abstract: En | Text: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil
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Raposo, Camila Cristina Bastos Silva

; Santos, João Barberino

; Santos, Gisele Maria Campelo dos

; Gonçalves, Eloísa da Graça do Rosário

; Silva, Antonio Rafael da

Revista da Sociedade Brasileira de Medicina Tropical

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feb 2013, Volume 46 N. 1 Pages 67 - 72

Abstract: En | Text: En | PDF: En

INTRODUCTION: Malaria caused by Plasmodium vivax species has shown signs of severity, recorded with increasing frequency in the medical literature. This study aimed to characterize the signs of severe malaria by Plasmodium vivax in the State of Maranhão, Brazil. METHODS: A descriptive cohort study of patients assisted in the field and a historical and concurrent study of a series of cases among hospitalized patients were undertaken to identify the clinical and laboratory signs of severity. RESULTS: A total of 153 patients were included in the study, 13 of whom were hospitalized. Males made up the majority, numbering 103 (67.3%). The age of the patients ranged from 10 to 70 years, 92.2% were natives of the State of Maranhão, and 65% of the patients had had malaria before. The average time elapsed between symptom onset and diagnosis among outpatients was three days, while among hospitalized patients this average reached 15.5 days, a statistically significant difference (p=0.001). The parasitemia ranged from 500 to 10,000 parasites/µl in 92.8% of cases. The clinical and laboratory manifestations of severity were vomiting and diarrhea, jaundice, drowsiness, mental confusion, seizures, loss of consciousness, agitation, bleeding, pale skin, coughing and dyspnea, thrombocytopenia, anemia, elevation of nitrogenous compounds, and elevated transaminases and bilirubin. CONCLUSIONS: The monitoring of malaria patients with Plasmodium vivax showed the possibility of aggravation, the intensity of which varied in different circumstances, especially the interval time between falling ill and diagnostic confirmation.

https://doi.org/10.1590/0037-868212382013 4070 downloads

Frequência de anticorpos aos agentes etiológicos da síndrome da imunodeficiência adquirida, sífilis, hepatites virais B e C e doença de Chagas em pacientes reumatológicos em tratamento com antifator de necrose tumoral (Tumor Necrosis Factor - TNF)
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Silva, Bárbara Santos Pires da

; Endo, Ana Cristina

; Medeiros, Ana Cristina de

; Gonçalves, Carla

; Moraes, Júlio César Bertacini de

; Bonfá, Eloísa

; Carvalho, Jozélio Freire de

Revista Brasileira de Reumatologia

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oct 2009, Volume 49 N. 5 Pages 590 - 598

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: Os pacientes reumatológicos em terapia com antifator de necrose tumoral (anti-TNF, Tumor Necrosis Factor) são considerados imunodeprimidos. Neste sentido, a pesquisa de doenças infecciosas nesta população é imperiosa devido à alta morbidade e, por vezes, mortalidade associada a este quadro. OBJETIVOS: O presente trabalho teve por objetivo avaliar a frequência de soropositividade para os seguintes agentes infecciosos: Treponema pallidum (sífilis), Trypanosoma cruzii (doença de Chagas), vírus da imunodeficiência humana adquirida (Human imunnodeficiency Virus - HIV) e hepatites B e C (HBV e HCV, respectivamente) em pacientes recebendo terapia anti-TNF. PACIENTES E MÉTODOS: Foram avaliados 143 pacientes reumatológicos em um estudo observacional, com artrite reumatoide, espondilite anquilosante, artrite psoriásica e outras doenças, em uso de terapia anti-TNF (adalimumabe, etanercepte e infliximabe) no período de setembro de 2007 a novembro de 2008. Foram coletados dados clínicos e demográficos, bem como uma amostra de sangue para a análise da presença de anticorpos contra os agentes infecciosos HIV (Aids), HBV e HCV (hepatites B e C, respectivamente), Treponema pallidum (sífilis) e Trypanosoma cruzii (doença de Chagas). RESULTADOS: A média de idade da população estudada foi de 45,78 ± 12,7 anos, sendo 60,1% do sexo feminino e 76,9% de cor branca. Treze (9%) dos pacientes apresentaram pelo menos uma sorologia positiva. Nenhum dos pacientes apresentou sorologia positiva para o Trypanosoma cruzii (doença de Chagas), bem como para HIV. Somente dois (1,4%) indivíduos apresentaram positividade para o Treponema pallidum (sífilis) (ELISA positivo e VDRL negativo). A frequência de anti-HBc total foi de 5% (7/140), sendo que todos estes foram positivos também para anti-HBs. O HBsAg foi negativo em todos os pacientes. Quatro pacientes tiveram HCV positivo, sendo que dois deles tinham PCR negativo para o vírus e os outros dois foram positivos e estavam estáveis. CONCLUSÃO: A frequência de soropositividade para certas doenças infecciosas em pacientes em terapia com anti-TNF é baixa. Os indivíduos que merecem maior atenção são aqueles com sorologia positiva para o HCV.

INTRODUCTION: Patients with rheumatic diseases treated with anti-tumor necrosis factor (anti-TNF) are considered to be immunosuppressed. Therefore, investigation for infectious diseases is mandatory in this population due to the high morbidity and, occasionally, mortality associated with this condition. OBJECTIVES: The objective of the present study was to evaluate the frequency of seropositivity for the following infectious agents: syphilis, Chagas' disease, acquired human immunodeficiency virus (HIV), and hepatitis B and C in patients under anti-TNF therapy. PATIENTS AND METHODS: This observational study evaluated 143 rheumatology patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and others, under anti-TNF therapy (adalimumab, etanercept, and infliximab) from September 2007 to November 2008. Clinical and demographic data, as well as presence of antibodies against HIV, hepatitis B and C, syphilis, and Chagas' disease, were evaluated. RESULTS: The study population had a mean age of 45.78 ± 12.7 years; 60.1% were females and 76.9% Caucasian. Thirteen (9%) patients had at least one positive serology. None of the patients had antibodies to Chagas' disease and HIV. Only two (1.4%) individuals were positive for syphilis (positive ELISA and negative VDRL). The frequency of total anti-HBc was 5% (7/140), and those patients were also positive for anti-HBs. All patients were negative for AgHBs. Four patients were HCV positive: and two of them had negative virus PCR and the other two were positive, but they were stable. CONCLUSION: The frequency of seropositivity for different infectious diseases in patients under anti-TNF therapy is low. Individuals with positive serology for hepatitis C deserve close attention.

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Caracterização de genótipos de Plasmodium vivax na Ilha de São Luís, Estado do Maranhão
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Gonçalves, Eloísa da Graça do Rosario

; Machado, Ricardo Luiz Dantas

; Santos, Ana Rosa dos

; Raposo, Camila Cristina Bastos Silva

; Matos, Wilma Batista de

; Silva, Antonio Rafael da

Revista da Sociedade Brasileira de Medicina Tropical

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jun 2009, Volume 42 N. 3 Pages 315 - 317

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O estudo foi desenvolvido com o objetivo de caracterizar os genótipos da proteína circunsporozoíta de Plasmodium vivax, circulantes em área periférica da Ilha de São Luís, Maranhão. Foram obtidas amostras de sangue para exame parasitológico direto (gota espessa) de 126 indivíduos, dentre os quais, foram coletadas também 109 amostras para diagnóstico molecular, por reação em cadeia da polimerase. O exame parasitológico demonstrou a presença de Plasmodium vivax em 2 indivíduos, sintomáticos, enquanto o estudo molecular foi positivo para o Plasmodium vivax em 7 indivíduos (2 sintomáticos e positivos na gota espessa e 5 assintomáticos e negativos na gota espessa). Em dois havia associação com Plasmodium falciparum. A genotipagem das amostras de Plasmodium vivax revelou a variante VK 210, havendo associação com a variante VK 247 em duas delas.

This study was developed with the aim of characterizing Plasmodium vivax circumsporozoite protein genotypes on the Island of São Luís, Maranhão. Blood samples were taken for direct parasitological examination (thick blood film) from 126 individuals. Among these individuals, 109 samples were also taken for molecular diagnosis by means of the polymerase chain reaction. The parasitological examination showed the presence of Plasmodium vivax in two symptomatic individuals, while the molecular study was positive for Plasmodium vivax in seven individuals (two symptomatic and positive from the thick blood film and five asymptomatic and negative from the thick blood film). Two samples showed an association with Plasmodium falciparum. Genotyping of the Plasmodium vivax samples showed that the VK 210 variant was present. This was associated with the VK 247 variant in two samples.

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Comparação da atividade de ácidos graxos essenciais e biomembrana na microbiota de feridas crônicas infectadas
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Quege, Geovana Eloisa

; Bachion, Maria Márcia

; Lino Junior, Ruy de Souza

; Lima, Ana Beatriz Mori

; Ferreira, Priscila Santos

; Santos, Queiliene Rosa dos

; Pimenta, Fabiana Cristina

Revista Eletrônica de Enfermagem

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dec 2008, Volume 10 N. 4 Pages 890 - 905

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

For patients cured of leprosy, low-limb ulcers represent a challenge to healthcare workers, for being chronic, infected, and recurrent. This study aimed to compare the latex biomembrane (Biocure™) and an EFA-based product (Dersani™) action on the microbiota of infected chronic wounds, in patients discharged from the treatment of leprosy. This is a research carried out at Hospital de Dermatologia Sanitária, in Goiânia-GO, from February to October 2007, in which 8 individuals cured of leprosy, having 19 infected wounds, were randomly allocated in group A (Dersani ™) and group B (Biocure™). Staphylococcus aureus (50%), Pseudomonas aeruginosa (35.7%), Proteus vulgaris (8.2%), Enterobacter aerogenes (3.3%), and Escherichia coli (2.7%) were isolated. The results obtained in vivo suggest that Dersani™ has a positive antimicrobial effect against Enterobacter aerogenes and Biocure™ against Pseudomonas aeruginosa, despite the in vitro results having shown absence of antimicrobial activity for both products against microorganisms standard and isolated from the wounds.

En pacientes curados de hanseníse, las úlceras en los miembros inferiores representan un desafío para los especialistas, por el hecho de ser crónicas, infectadas y frecuentes. Esta investigación tuvo como objetivo general, comparar la acción de una biomembrana de látex (Biocure®) y de un producto a base de AGE (Dersani®) en la microbiota de heridas crónicas infectadas, en pacientes que fueron dados de alta en el tratamiento de hanseníase. Se trata de una investigación realizada en el Hospital de la Sanidad Dermatológica, de Goiânia-GO, para la cual participaron 8 personas curadas de hanseníase, con 19 heridas infectadas, estas fueron separadas indistintamente en: grupo A ( tratado con Dersani ®) y en el grupo B (tratado con Biocure®). Fueron identificados Staphylococcus aureus (50%), Pseudomonas aeruginosa (35,7%), Proteus vulgaris (8,2%), Enterobacter aerogenes (3,3%), y Escherichia coli 05 (2,7%). Los resultados obtenidos in vivo nos sugieren que el Dersani® tenga un efecto antimicrobiano positivo contra el Enterobacter aerogenes y el Biocure® contra las Pseudomonas aeruginosa, aunque los resultados in vitro hayan mostrado ausencia de actividad de ambos productos contra los microorganismos aislados en las lesiones.

Em pessoas curadas de hanseníase, as úlceras em membros inferiores representam um desafio aos profissionais, por serem crônicas, infectadas e recorrentes. Esta pesquisa teve como objetivo comparar a ação de uma biomembrana de látex (Biocure®) e de um produto à base de AGE (Dersani®) na microbiota de feridas crônicas infectadas, em pessoas que receberam alta do tratamento para hanseníase. Trata-se de pesquisa realizada no Hospital de Dermatologia Sanitária, de Goiânia (GO), no período de fevereiro a outubro de 2007, na qual participaram 8 pessoas curadas de hanseníase, com 19 feridas infectadas, que foram, alocadas aleatoriamente em grupo A (tratado com Dersani®) e grupo B (tratado com Biocure®). Foram identificados Staphylococcus aureus (50%), Pseudomonas aeruginosa (35,7%), Proteus vulgaris (8,2%), Enterobacter aerogenes (3,3%) e Escherichia coli (2,7%). Os resultados obtidos in vivo sugerem que o Dersani® tenha efeito antimicrobiano positivo sobre: Enterobacter aerogenes e o Biocure® sobre: Pseudomonas aeruginosa. Os resultados in vitro mostraram ausência de atividade de ambos os produtos sobre os microrganismos isolados das lesões.

3 downloads Cited 3 times in SciELO

10.

Proposição de procedimento de detecção sistemática de perturbações oftalmológicas em escolares
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Figueiredo, Rosely Moralez de

; Santos, Eloisa Cristina dos

; Almas de Jesus, Ivonete Ap.

; Castilho, Rosa Maria

; Santos, Edmar Vieira dos

Revista de Saúde Pública

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 1993, Volume 27 N. 3 Pages 204 - 209

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Proposição de um procedimento de detecção sistemática de perturbações oftalmológicas em escolares, com participação do pessoal da escola. A partir de levantamento realizado em escolas estaduais que oferecem ciclo básico, da cidade de São Carlos, SP (Brasil), foi proposta a realização de teste de acuidade visual. Nove escolas participaram do estudo. Os professores das escolas foram treinados e realizaram os testes de acuidade visual e estrabismo nos seus alunos, de forma padronizada. Das 2.025 crianças testadas, 88,1% apresentaram níveis de acuidade visual maiores que 0,8 e uma prevalência de estrabismo de 2,17%. Finalizada a aplicação dos testes, cada escola apresentou propostas para aplicação sistemática do teste. As propostas têm em comum a realização dos testes pelos professores com a supervisão pelos coordenadores do ciclo básico, cabendo à enfermeira assessoria a todos os níveis de atividades do programa.

The proposal for a visual acuity test (A. V.) arose from a survey conducted among School Children of the "Ciclo Básico (C.B.)" i. é., the first two years of Elementary School in S. Carlos, S. Paulo State, Brazil. Nine schools participated in this study. The teachers were properly trained to apply the A. V. and squinting tests according to a standardized procedure. Of 2,025 children tested, 88.1% showed levels of A. V. higher than 0.8, and a squinting prevalence of 2.17%. When the application of the test was over, each school presented its proposals for the systematical application of such tests. These proposals had a common point: the test should be applied by the teachers themselves under the supervision of the co-ordinators of the C. B. The school nurse would be responsible for giving overall assistance to all the activities of the program at all levels.

866 downloads Cited 7 times in SciELO

11.

Proposição de procedimento de detecção sistemática de perturbações oftalmológicas em escolares
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Figueiredo, Rosely Moralez de

; Santos, Eloisa Cristina dos

; Almas de Jesus, Ivonete Ap.

; Castilho, Rosa Maria

; Santos, Edmar Vieira dos

Revista de Saúde Pública

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 1993, Volume 27 N. 3 Pages 204 - 209

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

2342 downloads Cited 7 times in SciELO

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