Search | SciELO

Need help?

Add field +

Search history

No documents were found for your search

Results: 25

au:Santos, Bianca L.

Filters

Collection

All
Brazil

25

Journal + Options

All
Pesquisa Veterinária Brasileira

7
Journal of the Brazilian Chemical Society

6
Anais da Academia Brasileira de Ciências

3
Advances in Weed Science

1
Brazilian Journal of Microbiology

1
Brazilian Journal of Psychiatry

1
Clinics

1
Memórias do Instituto Oswaldo Cruz

1
Revista Brasileira de Engenharia Agrícola e Ambiental

1
Revista Brasileira de Farmacognosia

1
Revista da Sociedade Brasileira de Medicina Tropical

1
Zoologia (Curitiba)

1

Language

All
Portuguese

5

Publication Year + Options

All
2021

6
2018

3
2019

3
2022

3
2011

2
2013

2
2014

2
2009

1
2016

1
2020

1
2023

1

SciELO Thematic Areas + Options

All
Agricultural Sciences

9
Exact and Earth Sciences

6
Health Sciences

5
Biological Sciences

3
Multidisciplinary

3

Show all...

WoS Subject Categories + Options

All
Sciences

11
Multidisciplinary

9
Veterinary

7
Chemistry

6
Medicine

3
Tropical

2
Agricultural

1
Agronomy

1
Engineering

1
Environmental

1
General

1
Internal

1
Microbiology

1
Parasitology

1
Pharmacology

1

Show all...

WoS Citation Index + Options

All
Science Citation Index Expanded

16
Social Sciences Citation Index

8

Citables and non citables

All
Citable

25

Type of Literature

All
Article

25

Order by

Page of 2 Next

Select this page

Print | Send to email | Export |

Facebook
Twitter
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

0 Selected itens

List all
Erase all

Integrated weed management strategies in a long-term crop rotation system
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Rudell, Eduardo C.

; Zanrosso, Bianca A.

; Frandaloso, Dieferson

; Giacomini, Argel J.

; Spadotto, Daelcio V.

; Vargas, Leandro

; Nunes, Anderson L.

; Santos, Fernando M.

Advances in Weed Science

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2023, Volume 41 elocation e020220053

Abstract: En | Text: En | PDF: En

Abstract Background Diversified crop systems provide several advantages for crop production and the agricultural ecosystem. In contrast, growing the same crop for consecutive years increases weeds, insects, and diseases issues, adding further cost to crop production owing to their management. Objective The objective was to evaluate the effects of six different winter cover crops and compare the impacts of a diversified rotation system in contrast to the succession system, combined with three different post-emergence herbicide management looking up to soybean yield, aboveground mass production, and weed density impact. Methods The experiment was performed over 2014 to 2018, using a randomized block design with four replications. Cover crop treatments were 1) fallow 2) wheat 3) rye 4) rye + turnip 5) rye + vetch 6) black oats. At the time of cover crop termination, weed density was counted and aboveground mass was measured. The crop rotation system was an alternated soybean and corn using three different post-emergence herbicide treatments, and the succession system was soybean each year. When a significant effect was observed after test F, the Tukey test (p ≤ 0.05) was applied to compare treatment effects. Results Rye + vetch as a cover crop, rotation system, and herbicide usage showed a higher impact on weed density. Rye + turnip has produced more aboveground biomass. Soybean yield was higher after wheat. Conclusions Cover crops implementation, crop rotation system, and herbicide usage have increased biomass production and crop yield, and reduced weed density showing integrated weed management as a key strategy for production systems.

https://doi.org/10.51694/advweedsci/2023;41:00026

Extracts of the Native Brazilian Tree Garcinia gardneriana Inhibit Urediniospore Germination of Coffee Leaf Rust Fungus
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Silva, Ueveton P. da

; Ferreira, Bruno W

; Sousa, Bianca L. de

; Furlani, Gabriela M

; Barreto, Robert W

; Agrizzi, Ana Paula

; Leite, João Paulo V

; Santos, Marcelo H. dos

; Varejão, Eduardo V. V

Journal of the Brazilian Chemical Society

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 2022, Volume 33 N. 3 Pages 217 - 226

Abstract: En | Text: En | PDF: En

The fungal Hemileia vastatrix is the causal agent of coffee leaf rust, one of the worst and devastating disease in coffee cultures worldwide. As a result of our research on natural products for the development of novel agrochemicals, we found that the hexane extract from leaves of the Brazilian medicinal plant Garcinia gardneriana, at 500 μg mL-1, inhibited in 98% the germination of H. vastatrix urediniospores. This extract showed no phytotoxicity when tested for seed germination and seedling growth inhibitory activity using sensible plant species. Also, the hexane extract from leaves was tested for anti-acetylcholinesterase activity, which constitutes a mechanism of action of major commercial insecticides used in agriculture, and showed low activity even at concentrations about two times higher than the half maximal inhibitory concentration (IC50) found in the antifungal assays. Gas chromatography-mass spectrometry (GC-MS) analysis showed that the hexane extract is constituted mainly by the pentacyclic triterpene lupeol, together with a series of sesquiterpenes as minor components. This is the first report on the investigation of antifungal, phytotoxic and acetylcholinesterase activities of extracts from leaves of G. gardneriana. These findings indicate that G. gardneriana may constitute a promising source of natural products for controlling the coffee leaf rust fungus.

https://doi.org/10.21577/0103-5053.20210139

Cordyceps cateniannulata and Cordyceps javanica: first report of pathogenicity to Glycaspis brimblecombei (Hemiptera: Aphalaridae)
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

DOMINGUES, MAURÍCIO M.

; SANTOS, PAULA L.

; GÊA, BIANCA C.C.

; CARVALHO, VANESSA R.

; OLIVEIRA, FABRICIO N.

; SOLIMAN, EVERTON P.

; PEREIRA, FABRICIO F.

; ZANUNCIO, JOSÉ C.

; WILCKEN, CARLOS F.

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, Volume 94 elocation e20211566

Abstract: En | Text: En | PDF: En

Abstract Cultivation of species of the genus Eucalyptus is important for the Brazilian economy, with 6.97 million hectares planted. Glycaspis brimblecombei Moore (Hemiptera: Aphalaridae), detected in Brazil in 2003, has dispersed and now damages Eucalyptus crops in all regions of this country. The location and identification of entomopathogenic fungi isolates may increase the options for integrated pest management. The objective of this research was to evaluate the pathogenicity of Cordyceps cateniannulata and Cordyceps javanica isolates to G. brimblecombei. Ten nymphs of G. brimblecombei, with or without lerps, were placed per Eucalyptus leaf cut with one of its edges on hydroretentive gel inside Petri dishes. The fungi isolates were suspended in a solution of Tween 80 (0.1%) at the concentration of 1.0 x 108 conidia mL-1 and sprayed on the G. brimblecombei nymphs. The mortality of this insect was evaluated daily for seven days, and the dead individuals were transferred to humid chambers. The conidia viability of the isolates was greater than 93%. The mortality of G. brimblecombei nymphs, seven days after the application of the fungi, was 100%. This is the first report of the pathogenicity of C. cateniannulata and C. javanica isolates, occurring naturally in the field, to G. brimblecombei.

https://doi.org/10.1590/0001-3765202220211566

Botanical sources and heavy metals contents of honey produced by Apis mellifera in an ecotone region of the state of Bahia, Brazil
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

SILVEIRA-JÚNIOR, CRISTIANO EDUARDO A.

; LOPES, BIANCA A.

; SILVA, TÂNIA MARIA S.

; GOMES, AYALA NARA P.

; SILVA, GIRLIANE REGINA DA

; ARRUDA, RAFAEL S. DE

; MACIEL, EDSON A.

; SANTOS, FRANCISCO A.R. DOS

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, Volume 94 Suppl. 4 elocation e20211551

Abstract: En | Text: En | PDF: En

Abstract The present study investigated by palynological and chemical analysis (Flame Atomic Absortion Spectrometry) about the botanical origin and the heavy metals content (arsenic, cadmium, chromium, lead and mercury) of monthly honey samples of Apis mellifera L. over two years. The pollen types Apiaceae, Mimosa caesalpiniifolia, M. tenuiflora and Myrcia indicated the main floristic sources used by bees. M. tenuiflora was the most frequent of the pollen types, and because it predominates in different months in each year, which may indicate more than one species of the genus being foraged by the beehive. The climatic influence (rainfall and temperature) on the pollen diversity was investigated and was not statistically supported. The chemical analysis showed that the heavy metal content of the samples were below their respective limits of quantification, and, therefore, the samples can be considered safe for human consumption.

https://doi.org/10.1590/0001-3765202220211551

Absolute Configuration Reassignment of Natural Products: An Overview of the Last Decade
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Batista, Andrea N. L.

; Angrisani, Bianca R. P.

; Lima, Maria Emanuelle D.

; Silva, Stephanie M. P. Da

; Schettini, Vitória H.

; Chagas, Higor A.

; Santos Jr., Fernando M. dos

; Batista Jr., João M.

; Valverde, Alessandra L.

Journal of the Brazilian Chemical Society

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2021, Volume 32 N. 8 Pages 1499 - 1518

Abstract: En | Text: En | PDF: En

The assignment of absolute configuration (AC) is a crucial step in the structural characterization of natural products, especially for those subjected to biological assays. Methods such as X-ray crystallography, stereocontrolled organic synthesis, nuclear magnetic resonance (NMR), and chiroptical spectroscopies are commonly used to determine the AC of chiral natural compounds. Even with these well-established techniques, however, unambiguous stereochemical assignments of natural products remain a challenge, resulting in an increasing number of structural misassignments being reported every year. Herein, we will present the main techniques that have been used in AC reassignments of natural products over the last 10 years, along with some selected examples. Special attention will be paid to the strengths and weaknesses of each approach. With this, we expect to provide the readers with critical information to help them to choose the appropriate methods for correct AC determinations.

https://doi.org/10.21577/0103-5053.20210079 142 downloads

Quality variables for technological application of cocoa clones from the Brazilian semiarid region
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Reges, Bianca M.

; Maia, Anielly M.

; Sarmento, Diogenes H. A.

; Silva, Mayara S.

; Santos, Sandra M. L. dos

; Damaceno, Marlene N.

Revista Brasileira de Engenharia Agrícola e Ambiental

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 2021, Volume 25 N. 3 Pages 203 - 208

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A caracterização dos clones de cacau produzidos no semiárido faz-se necessária para aumentar a base de dados sobre esses clones implantados e assim melhorar a qualidade dos seus subprodutos. Dessa forma, objetivou-se avaliar as características físicas, químicas e físico-químicas dos clones CCN 51, CEPEC 2004, CEPEC 2005 e PS 1319, produzidos no Vale do Jaguaribe no Estado do Ceará e indicá-los para um processo ou produto alimentício. Os clones foram avaliados quanto às características físicas (massa total do fruto, casca, polpa, sementes, cibirra e polpa com sementes; diâmetro transversal (DTF) e longitudinal (DLF) do fruto e a relação DTF/DLF; espessura da casca externa (ECE) e interna (ECI) e a relação ECE/ECI; número, espessura, diâmetro transversal (DTS) e longitudinal (DLS) das sementes e a relação (DTS/DTS); rendimento e cor da polpa), químicas (umidade, lipídios, proteína, cinzas, fibra bruta e carboidratos) e físico-químicas (acidez titulável, pH, sólidos solúveis e açúcares redutores). Os clones CCN 51 e o CEPEC 2005 são os mais indicados para o processo de fermentação de cacau. Para doces, geleias, polpa e nibs para dieta com restrição de gordura indicam-se os clones CCN 51, CEPEC 2005, PS 1319 e CEPEC 2004, respectivamente.

ABSTRACT Characterization of cocoa clones produced in the semiarid region is necessary to enlarge the database about these implanted clones and thus enhance the quality of their by-products. Therefore, this study aims to evaluate physical, chemical, and physicochemical characteristics of the CCN 51, CEPEC 2004, CEPEC 2005, and PS 1319 clones, produced in the region of Vale do Jaguaribe in the state of Ceará (Brazil), and to suggest food processes or products for them. The clones were evaluated according to their physical traits (total fruit mass, rind, pulp, seeds, and placenta and pulp with seeds), fruit transverse diameter (FTD), fruit longitudinal diameter (FLD), the ratio FTD/FLD; rind external thickness (ERT), rind internal thickness (IRT), the ratio ERT/IRT, number of seeds, seed thickness, seed transverse diameter (STD), seed longitudinal diameter (SLD), and the ratio STD/SLD, yield, pulp color, chemical traits (humidity, lipids, proteins, ashes, crude fiber, and carbohydrates), and physicochemical traits (titratable acidity, pH, soluble solids, and reducing sugars) were evaluated. The CCN 51 and CEPEC 2005 clones are the most suitable for the process of cocoa fermentation. For desserts, jams, pulp, and nibs for fat-restricted diets, the most suitable clones are CCN 51, CEPEC 2005, PS 1319 and CEPEC 2004, respectively.

https://doi.org/10.1590/1807-1929/agriambi.v25n3p203-208 430 downloads

Inhibition of Acetylcholinesterase by Coumarin-Linked Amino Acids Synthetized via Triazole Associated with Molecule Partition Coefficient
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Sousa, Bianca L. de

; Leite, João P. V.

; Mendes, Tiago A. O.

; Varejão, Eduardo V. V.

; Chaves, Anna C. S.

; Silva, Júnio G. da

; Agrizzi, Ana P.

; Ferreira, Priscila G.

; Pilau, Eduardo J.

; Silva, Evandro

; Santos, Marcelo H. dos

Journal of the Brazilian Chemical Society

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 2021, Volume 32 N. 3 Pages 652 - 664

Abstract: En | Text: En | PDF: En

A previous study for the identification of acetylcholinesterase (AChE) inhibitors demonstrated that the hybrid between tyrosol, the 1,2,3-triazole nucleus, and the coumarin group, namely 7-({1-[2-(4-hydroxyphenyl)ethyl]-1H-1,2,3-triazol-4-yl}methoxy)-4-methyl-2H-chromen-2-one (10), has a high enzyme inhibitory activity. Here, we synthesized analogues of 10 via triazole with pharmacophoric groups represented by tyrosine, phenylalanine, tryptophan, and glycine in addition to evaluating the impact of coumarin-linked amino acids on AChE inhibition. We obtained eight triazoles, six of which are undescribed. In general, the presence of carboxylic acid decreased the inhibitory activity, while aromatic amino acids increased enzymatic inhibition compared to glycine. The derivative containing tyrosine, structurally most similar to 10, presented the lowest inhibition percentage, indicating that phenolic hydroxyl is not the preponderant factor for inhibition. Molecular docking was not enough to explain in vitro experiments. On the other hand, MlogP (logP calculated by the Moriguchi method) was related positively to enzymatic inhibition. To increase the hydrophobicity of the molecules, we tested the esterified triazole derivatives comparatively with the enzyme. The compound ethyl 2-(4-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)acetate (6) presented an increment of inhibitory activity of 46.97 ± 1.75% at 100 μmol L-1. We also associated the best activity with the lowest van der Waals volume and molar mass values.

https://doi.org/10.21577/0103-5053.20200219 184 downloads

Synthesis of 1,2,3-Triazole Benzophenone Derivatives and Evaluation of in vitro Sun Protection, Antioxidant Properties, and Antiproliferative Activity on HT-144 Melanoma Cells
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Dias, Maria C. F.

; Sousa, Bianca L. de

; Ionta, Marisa

; Teixeira, Róbson R.

; Goulart, Thiago Q.

; Ferreira-Silva, Guilherme Á.

; Pilau, Eduardo J.

; Santos, Marcelo H. dos

Journal of the Brazilian Chemical Society

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 2021, Volume 32 N. 3 Pages 572 - 587

Abstract: En | Text: En | PDF: En

Benzophenones display several biological activities, including antioxidant, anticancer, and photoprotective. Furthermore, antioxidants can minimize both ultraviolet absorption and tumor development. In the present investigation, a series of twenty-six 1,2,3-triazole-benzophenone derivatives were synthesized and had their antioxidant, anticancer, and photoprotective effects evaluated. For the compounds synthesis, 4,4’-dihydroxybenzophenone (1a) and 2,4-dihydroxybenzophenone (1b) were propargylated, affording the alkynes bis(4-(prop-2-yn-1-yloxy))benzophenone (2a) and (2-hydroxy-4-(prop-2-yn-1-yloxy))benzophenone (2b), respectively. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between the compounds 2a/2b and several benzyl azides gave the 1,2,3-triazole-benzophenone derivatives with yields ranging from 35 to 95%. The 1,2,3-triazole-benzophenone derivatives at the concentration of 0.2 μg mL-1 (a no-cytotoxic concentration) exhibited a solar protection factor (SPF) comparable to positive control benzophonen-3 (BP-3). Concerning their antioxidant and cytotoxic effects, the derivatives from 1b showed high in vitro antioxidant effects as well as cytotoxicity against A549 (lung carcinoma), MCF-7 (breast carcinoma), and HT-144 (metastatic melanoma) cell lines, without significant cytotoxicity to a non-cancerous cell line. Derivatives 19, 20, and 24 induced cell death and cell cycle arrest at G1/S in HT-144 melanoma cells.

https://doi.org/10.21577/0103-5053.20200211 324 downloads

Cytogenotoxicity and protective effect of piperine and capsaicin on meristematic cells of Allium cepa L.
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

DIAS, MARCONDES S.

; JUNIOR, ERASMO P.V.

; SANTOS, BIANCA C. DOS

; MARTINS, FRANCIELLE A.

; ALMEIDA, PEDRO M. DE

; PERON, ANA P.

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 93 elocation e20201772

Abstract: En | Text: En | PDF: En

Abstract Piperine and capsaicin are important molecules with biological and pharmacological activities. This study aimed to evaluate the cytogenotoxic and protective effect of piperine and capsaicin on Allium cepa cells. A. cepa roots were exposed to negative (2% Dimethylsulfoxide) and positive (Methylmethanesulfonate, MMS, 10 µg/mL) controls, and four concentrations (25-200 µM) of piperine or capsaicin (alone) or associated before, simultaneously or after with the MMS. Only the lowest concentration of piperine (25 µM) showed a protective effect because it was not genotoxic. Piperine and capsaicin were cytotoxic (50, 100 and 200 µM). Piperine (50 to 200 µM) caused a significant increase in the total average of chromosomal alterations of in A. cepa cells. For capsaicin, the genotoxic effect was dose-dependent with a significant increase for all concentrations, highlighting the significant presence of micronuclei and nuclear buds for the two isolates. In general, bioactive compounds reduced the total average of chromosomal alterations against damage caused by MMS, mainly micronuclei and/or nuclear buds. Therefore, the two molecules were cytotoxic and genotoxic at the highest concentrations, and did not have cytoprotective action, and the lowest concentration of piperine demonstrated important chemopreventive activity.

https://doi.org/10.1590/0001-3765202120201772 90 downloads

10.

Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Helito, Alberto C.

; Lindoso, Livia

; Sieczkowska, Sofia M.

; Astley, Camilla

; Queiroz, Ligia B.

; Rose, Natalia

; Santos, Claudia Renata P.

; Bolzan, Thalis

; Peralta, Rita María I.A.

; Franco, Ruth R.

; Cominato, Louise

; Pereira, Rosa Maria R.

; Tannuri, Uenis

; Campos, Lucia Maria A.

; Lourenço, Benito

; Toma, Ricardo K.

; Medeiros, Karina

; Watanabe, Andréia

; Grangeiro, Patricia Moreno

; Farhat, Sylvia C.

; Casella, Caio B.

; Polanczyk, Guilherme V.

; Gualano, Bruno

; Silva, Clovis A.

; Sallum, Adriana M. E.

; Iraha, Amanda Y.

; Ihara, Bianca P.

; Mazzolani, Bruna C.

; Martinez, Claudia A.

; Strabelli, Claudia A. A.

; Fonseca, Claudia B.

; Lima, Dandara C. C.

; Setoue, Debora N. D.

; Roz, Deborah F. P.

; Smaira, Fabiana I.

; Roschel, Hamilton

; Miyatani, Helena T.

; Marques, Isabela G.

; Oba, Jane

; Ferreira, Juliana C. O.

; Simon, Juliana R.

; Kozu, Katia

; Saccani, Ligia P.

; Martiniano, Lorena V. M.

; Miranda, Luana C. A.

; Silva, Luiz E. V.

; Laurentino, Moisés F.

; Aikawa, Nadia E.

; Sakita, Neusa K.

; Tanigava, Nicolas Y.

; Pereira, Paulo R. A.

; Palmeira, Patrícia

; Angelo, Simone S.

; Lavorato, Sofia S. M.

; Bernardes, Tamires M.

; Franco, Tathiane C.

; Viana, Vivianne S. L.

; Barros, Vera P. M. F. R.

; Zheng, Yingying

Clinics

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 76 elocation e3501

Abstract: En | Text: En | PDF: En

OBJECTIVE: To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: This cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI). RESULTS: The median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001). CONCLUSION: Self-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.

https://doi.org/10.6061/clinics/2021/e3501

11.

Synthesis of 1,2,3-Triazole Derivatives of Hydnocarpic Acid Isolated from Carpotroche brasiliensis Seed Oil and Evaluation of Antiproliferative Activity
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Osorio, Liseth S.

; Ionta, Marisa

; Demuner, Antonio J.

; Sousa, Bianca L. de

; Ferraz, Guilherme O.

; Varejão, Eduardo V. V.

; Ferreira-Silva, Guilherme A.

; Pilau, Eduardo J.

; Silva, Evandro

; Santos, Marcelo H. dos

Journal of the Brazilian Chemical Society

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2020, Volume 31 N. 12 Pages 2500 - 2510

Abstract: En | Text: En | PDF: En

Carpotroche brasiliensis is a tree native to Brazil, belonging to the family Flacurtiaceae, whose seeds contain a group of cyclopentenyl fatty acids: gorlic (12%), chaulmugric (27%), and hydnocarpic (48.7%). These compounds are considered the main therapeutic agents in the treatment of leprosy. In the present study, a series of novel triazole compounds were obtained by conjugation between hydnocarpic acid and functionalized azides via copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC). Hydnocarpic acid and its derivatives were tested against estrogen-positive breast carcinoma (MCF-7), hepatocellular carcinoma (HepG2), and non-small cell lung cancer (A549) cell lines. The (R)-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl-11-(cyclopent-2-en-1-yl)undecanoate (8) displayed promising antiproliferative activity against A549 cells. We demonstrated that this compound selectively inhibited the viability of A549 cell cultures. Furthermore, compound 8 inhibited the clonogenic capacity of A549 cells, and this effect was associated to its ability to inhibit cell cycle progression at G1 phase. These findings indicate that 8 is a promising antitumor agent on A549 cells and support further studies to evaluate the molecular mechanisms underlying its antiproliferative activity. In addition, hydnocarpic acid should be considered as a promising chemical prototype to obtain novel antineoplastic agents.

https://doi.org/10.21577/0103-5053.20200125 331 downloads

12.

Epidemiological study of rabies in cattle in southern Brazil: spatial and temporal distribution from 2008 to 2017
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Bianca L.

; Bruhn, Fábio Raphael P.

; Coelho, Ana Carolina B.

; Estima-Silva, Pablo

; Echenique, Joanna V.

; Sallis, Eliza Simone V.

; Schild, Ana Lucia

Pesquisa Veterinária Brasileira

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jul 2019, Volume 39 N. 7 Pages 460 - 468

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A raiva afeta várias espécies domésticas, causando perdas econômicas significativas pela morte de animais em áreas bem características da região Sul do Rio Grande do Sul. Neste contexto, o objetivo deste trabalho foi estudar a epidemiologia dos surtos de raiva observados em bovinos de janeiro de 2008 a dezembro de 2017, por meio de sua distribuição no espaço e no tempo na região sul do Rio Grande do Sul. Foi realizado um estudo observacional e ecológico retrospectivo, por meio da análise de dados registrados nos protocolos de necropsias realizadas em bovinos no Laboratório Regional de Diagnóstico da Universidade Federal de Pelotas (LRD-UFPel). Foi feita análise descritiva dos dados para avaliar a distribuição dos casos ao longo do tempo. Para a análise temporal foi utilizado o software estatístico Gretl 1.9.12 (GNU Regression, Econometricand Time-series Library). Para verificar a existência da estacionariedade utilizou-se o teste de Dickey-Fuller aumentado, considerando um valor de p<0,05. No período de janeiro de 2008 a dezembro de 2017, foram recebidos no LRD-UFPel 1418 materiais de bovinos para diagnóstico, sendo confirmados 160 surtos de raiva em 160 propriedades situadas nos 24 municípios da área de influência do LRD-UFPel. O número de animais infectados pelo vírus foi de 591 bovinos de um total de 25.886. O presente estudo permitiu concluir que a raiva não tem sazonalidade na região do estudo, tendo tendência de queda na frequência nos próximos anos. A doença tem característica epidêmica na maioria dos meses analisados (2012-2014), mantendo-se endêmica no período restante (2011, 2015 e 2016) com episódios esporádicos de epidemias nestes anos. Observou-se ainda, que na medida em que aumentou a incidência da doença nos animais e nas propriedades, houve disseminação geográfica do vírus para a maioria (54,16%) dos municípios da área de influência do LRD-UFPel.

ABSTRACT: Rabies affects several domestic species, causing significant economic losses due to the death of animals in characteristic areas of the southern region of Rio Grande do Sul. In this context, this work aimed to study the epidemiology of rabies outbreaks observed in cattle from January 2008 to December 2017, through its space and time distribution in the southern region of Rio Grande do Sul. We performed an observational and ecological retrospective through the analysis of data recorded in necropsy protocols performed in cattle at the “Laboratório Regional de Diagnóstico” of the “Universidade Federal de Pelotas” (LRD-UFPel). A descriptive data analysis aimed at evaluating the distribution of cases over time. The statistical analysis was performed with Gretl statistical software 1.9.12 (GNU Regression, Econometric, and Time-series Library). To the existence of stationarity was verified with the Dickey-Fuller test, considering a value of p<0.05. From January 2008 to December 2017, 1418 bovine diagnostic materials were received at the LRD-UFPel, and 160 outbreaks of rabies were confirmed in 160 farms located in the 24 municipalities of the LRD-UFPel area of influence. We observed 591 cattle out of a total of 25,886 infected with the virus. We conclude that rabies does not exhibit seasonality in the study region, with a tendency to decrease in frequency in the next years. The disease has an epidemic characteristic in most of the analyzed months (2012-2014), remaining endemic in the remaining period (2011, 2015 and 2016) with sporadic episodes of epidemics in these years. We also observed that as the incidence of the disease increased in the animals and in the properties, there was a geographical spread of the virus for the majority (54.16%) of the municipalities in the area of influence of the LRD-UFPel.

https://doi.org/10.1590/1678-6160-pvb-6088 1125 downloads

13.

Clostridial diseases diagnosed in cattle from the South of Rio Grande do Sul, Brazil. A forty-year survey (1978-2018) and a brief review of the literature
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Bianca L.

; Ladeira, Silvia R.L.

; Riet-Correa, Franklin

; Soares, Mauro P.

; Marcolongo-Pereira, Clairton

; Sallis, Eliza Simone V.

; Raffi, Margarida B.

; Schild, Ana Lucia

Pesquisa Veterinária Brasileira

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jul 2019, Volume 39 N. 7 Pages 435 - 446

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Clostridioses são doenças produzidas por alguma das espécies do gênero Clostridium e são importantes causas de perdas pecuárias no sul do Rio Grande do Sul. Pesquisas anuais realizadas no Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas (LRD-UFPel) desde 1978 demonstraram que as clostridioses representaram 11,1% das doenças bacterianas diagnosticadas em bovinos e 1,65% de todos os diagnósticos de doenças em bovinos ao longo de 40 anos. O objetivo deste estudo é revisar os aspectos clínicos, epidemiológicos e patológicos das clostridioses diagnosticadas de janeiro de 1978 a dezembro de 2018, pelo LRD/UFPel com a intenção de que esse trabalho possa servir de guia útil para os veterinários de campo e fazendeiros interessados. Foram avaliados e revisados os protocolos de necropsia de 6.736 bovinos; essas necropsias foram realizadas pelo pessoal do LRD/UFPel ou por veterinários de campo. Cento e quatro (1,16%) casos foram diagnosticados como clostridioses, distribuídos da seguinte forma: 35 surtos de tétano, 34 de cartbúnculo sintomático, 23 de hemoglobinúria bacilar, 11 de edema maligno (gangrena gasosa) e oito de botulismo. Aproximadamente 904, de um total de 42.480 bovinos sob-risco, morreram nesses surtos.

ABSTRACT: Clostridial diseases are important causes of livestock losses in the southern Rio Grande do Sul. Since 1978 annual surveys conducted at the “Laboratório Regional de Diagnóstico” of the “Universidade Federal de Pelotas” (LRD-UFPel) have shown that clostridial diseases represent 10.40% of the bacterial diseases diagnosed in cattle and 1.65% of all diseases diagnosis in cattle over a 40-year period. The purpose of this study is to review the clinical, epidemiological and pathological aspects of the clostridial diseases diagnosed in cattle from January 1978 to December 2018 at the LRD-UFPel in the hopes that it will constitute a useful guide for field veterinary practitioners and interested farmers. We assessed and review the necropsy protocols of 6,736 cattle; these necropsies were performed either by LRD-UFPel faculty or by field veterinary practitioners; 111 outbreaks (1.65%) were diagnosed as clostridial disease, distributed as follows: 35 outbreaks of tetanus, 34 of blackleg, 23 of bacillary hemoglobinuria, 11 of malignant edema (gas gangrene), and eight of botulism. Approximately 904, from a total of 42,480 cattle at risk, died in these outbreaks.

https://doi.org/10.1590/1678-5150-pvb-6333 4316 downloads

14.

Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Ennes-Vidal, Vítor

; Vitório, Bianca da Silva

; Menna-Barreto, Rubem Figueiredo Sadok

; Pitaluga, André Nóbrega

; Gonçalves-da-Silva, Silvia Amaral

; Branquinha, Marta Helena

; Santos, André Luis Souza

; d’Avila-Levy, Claudia Masini

Memórias do Instituto Oswaldo Cruz

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2019, Volume 114 elocation e190147

Abstract: En | Text: En | PDF: En

BACKGROUND Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosomatids genome. OBJECTIVES Here, we characterised calpains in Leishmania braziliensis, the main causative agent of cutaneous leishmaniasis in Brazil. METHODS/FINDINGS In total, 34 predicted calpain-like genes were identified. After domain structure evaluation, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) during in vitro metacyclogenesis revealed (i) five genes with enhanced expression in the procyclic stage, (ii) one augmented gene in the metacyclic stage, and (iii) one procyclic-exclusive transcript. Western blot analysis revealed that an antibody against a consensus-conserved peptide reacted with multiple calpain-like proteins, which is consistent with the multi-gene family characteristic. Flow cytometry and immunocytochemistry analyses revealed the presence of calpain-like molecules mainly in the cytoplasm, to a lesser extent in the plasma membrane, and negligible levels in the nucleus, which are all consistent with calpain localisation. Eventually, the calpain inhibitor MDL28170 was used for functional studies revealing (i) a leishmaniostatic effect, (ii) a reduction in the association index in mouse macrophages, (iii) ultra-structural alterations conceivable with autophagy, and (iv) an enhanced expression of the virulence factor GP63. CONCLUSION This report adds novel insights into the domain structure, expression, and localisation of L. braziliensis calpain-like molecules.

https://doi.org/10.1590/0074-02760190147 1125 downloads

15.

In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides L.
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Jesus, Roberta S.

; Piana, Mariana

; Freitas, Robson B.

; Brum, Thiele F.

; Alves, Camilla F.S.

; Belke, Bianca V.

; Mossmann, Natália Jank

; Cruz, Ritiel C.

; Santos, Roberto C.V.

; Dalmolin, Tanise V.

; Bianchini, Bianca V.

; Campos, Marli M.A.

; Bauermann, Liliane de Freitas

Brazilian Journal of Microbiology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2018, Volume 49 N. 2 Pages 296 - 302

Abstract: En | Text: En | PDF: En

Abstract The main objective of this study was to demonstrate the antimicrobial potential of the crude extract and fractions of Chenopodium ambrosioides L., popularly known as Santa-Maria herb, against microorganisms of clinical interest by the microdilution technique, and also to show the chromatographic profile of the phenolic compounds in the species. The Phytochemical screening revealed the presence of cardiotonic, anthraquinone, alkaloids, tannins and flavonoids. The analysis by HPLC-DAD revealed the presence of rutin in the crude extract (12.5 ± 0.20 mg/g), ethyl acetate (16.5 ± 0.37 mg/g) and n-butanol (8.85 ± 0.11 mg/g), whereas quercetin and chrysin were quantified in chloroform fraction (1.95 ± 0.04 and 1.04 ± 0.01 mg/g), respectively. The most promising results were obtained with the ethyl acetate fraction, which inhibited a greater number of microorganisms and presented the lowest values of MIC against Staphylococcus aureus and Enterococcus faecalis (MIC = 0.42 mg/mL), Pseudomonas aeruginosa (MIC = 34.37 mg/mL), Paenibacillus apiarus (MIC = 4.29 mg/mL) and Paenibacillus thiaminolyticus (MIC = 4.29 mg/mL). Considering mycobacterial inhibition, the best results were obtained by chloroform fraction against M. tuberculosis, M. smegmatis, and M. avium (MIC ranging from 156.25 to 625 µg/mL). This study proves, in part, that the popular use of C. ambrosioides L. can be an effective and sustainable alternative for the prevention and treatment of diseases caused by various infectious agents.

https://doi.org/10.1016/j.bjm.2017.02.012 1714 downloads

Showing

itens per page

Page of 2 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »