Boron-manganese steel 22MnB5 is extensively used in structural automotive components. Knowledge about its microstructural evolution during hot stamping and resistance spot welding (RSW) is extremely relevant to guarantee compliance with application requirements. Particularly, corrosion properties are critical to the application of uncoated sheet steels. However, microstructural studies are usually simplified to top-hat geometries, which might not be fully representative of the complex thermomechanical cycles locally faced by a real component. Therefore, the present work brings an extensive characterization of a hot-stamped 22MnB5 automotive B-pillar in terms of microstructure, hardness and corrosion resistance, which were correlated with a reverse engineering of the process using numerical simulation. Physical simulations of the subcritical heat affected zone (SCHAZ) of RSW were done to assess the influence of microstructure on martensite tempering. Results showed that the component undergoes a complex strain distribution along its body during hot stamping. Most heavily strained regions presented higher amounts of ferrite, leading to poorer corrosion resistance, since ferrite behaves as an anode. Physical simulations of the SCHAZ showed that the softening degree due to martensite tempering is solely affected by peak temperature, while other microstructural features appear to exert negligible or no influence. Boronmanganese Boron manganese MnB 22MnB components (RSW requirements Particularly steels However tophat top hat geometries Therefore hotstamped stamped Bpillar B pillar simulation (SCHAZ anode temperature

The objective of this study was to evaluate the performance of F1 (Holstein × Zebu) cows in lactation according to different levels of substitution of soybean meal for a protein equivalent non-protein nitrogen originated from slow-release urea (SRU). Eight F1 (Holstein × Zebu) cows in the first third of lactation, with an average milk yield of 12.7 kg (±3.1 kg)/day and a live weight of 552 kg (±30 kg), were used. The experimental design was composed of two simultaneous 4 × 4 Latin squares, with the following treatments: 100% soybean meal and 0% SRU; 66% soybean meal and 34% SRU; 34% soybean meal and 66% SRU; and 0% soybean meal and 100% SRU. Sorghum silage, used as roughage, was supplied together with the concentrate. Feed intake and digestibility as well as milk yield and milk composition were measured. The obtained data were subjected to analysis of variance, adopting a 5% probability level. No intake variable showed significant differences among the treatments, and the mean values for the intakes of dry matter (DM), crude protein (CP) and neutral detergent fiber (NDF) were 18.35 2.62 and 5.85 kg/day, respectively. The results for apparent digestibility also did not show differences among treatments, with DM, CP and NDF averaging 58.16, 58.64 and 36.21%, respectively. Milk yield and composition were similar among the treatments. The average 4%-fat-corrected milk yield was 13.39 kg/animal day. Intake, digestibility and milk yield and composition variables are not changed according to the substitution of the soy protein for slow-release urea. Thus, for average-milk-yield crossbred.animals, this substitution depends on economic variables only.

RESUMO Pioderma gangrenoso é uma doença inflamatória imunomediada e rara da pele, de diagnóstico extremamente desafiador. A evolução clínica é a base para o diagnóstico, cursando com lesões pustulosas superficiais, halo eritematoso doloroso, rápida progressão para ulcerações dolorosas e estéreis, sem resposta a antibióticos ou a novas intervenções cirúrgicas e, finalmente, com pronta melhora com uso de imunossupressores. O atraso no diagnóstico pode acarretar numerosas internações e terapias prolongadas, sendo que seu reconhecimento precoce, por outro lado, evita a progressão dessas ulcerações e sua morbidade. Relatou-se um caso de pioderma gangrenoso que evoluiu após cirurgia associada à radioterapia intraoperatória no tratamento conservador do câncer de mama, fazendo-se uma revisão de casos relatados na literatura e suas possibilidades terapêuticas. Questiona-se, também, se a radioterapia intraoperatória estaria relacionada com algum estímulo imunomediado, o que poderia ter facilitado o desencadeamento do quadro. pele desafiador superficiais doloroso estéreis finalmente imunossupressores prolongadas precoce lado morbidade Relatouse Relatou mama fazendose fazendo terapêuticas Questionase, Questionase Questiona se, Questiona-se também imunomediado quadro

ABSTRACT Pyoderma gangrenosum is an immune-mediated inflammatory and rare skin disease with an extremely challenging diagnosis. The clinical evolution of the disease is the basis for the diagnosis that involves pustular superficial lesions, painful erythematous halo, rapid progression to painful and sterile ulcerations, unresponsiveness to antibiotics or new surgical interventions, and finally, ready improvement with the use of immunosuppressive drugs. Delayed diagnosis may cause numerous hospitalizations and prolonged therapy, whereas early recognition can prevent the progression of the ulcerations and their morbidities. We report a case of pyoderma gangrenosum that evolved after surgery and was associated with intraoperative radiotherapy for the conservative treatment of breast cancer. In addition, we reviewed reported cases in the literature and therapeutic options. It is conjectured that intraoperative radiotherapy might be related to some immune-mediated stimuli that could trigger the clinical condition. immunemediated immune mediated lesions halo interventions finally drugs therapy morbidities cancer addition options condition

Objetivou-se com o presente trabalho avaliar os efeitos de uma mistura comercial de óleos essenciais (capsaicina, eugenol, cinamaldeído e carvacrol) microencapsulados com inclusões crescentes (0; 1,5; 3,0 e 4,0g/dia) sobre o consumo, digestibilidade, desempenho e a composição do leite de 20 vacas Holandesas primíparas confinadas em baias com cama de areia. Não houve interação entre os tratamentos e os períodos avaliados, e o efeito dos tratamentos não foi significativo (P>0,05) para as variáveis consumo de matéria seca, expresso em % PV e em kg/dia, proteína bruta (% PV), extrato etéreo (% PV), fibra em detergente neutro (% PV), fibra em detergente ácido (% PV); digestibilidade da matéria seca (%), proteína bruta (%), extrato etéreo (%), fibra em detergente neutro (%); produção de leite (kg) e seus componentes gordura (%), proteína (%), lactose (%), sólidos totais (%), extrato seco desengordurado (%), contagem de células somáticas (log) e nitrogênio ureico (mg/dL). No entanto, avaliando separadamente os períodos testados, encontrou-se diminuição significativa (P<0,05) na produção de leite e aumento nas concentrações de sólidos totais (%). Não houve diferença (P>0,05) para os teores de extrato seco desengordurado (%) e contagem de células somáticas (log). Pôde-se concluir que a utilização de óleos essenciais contendo capsaicina, eugenol, cinamaldeído e carvacrol não influencia o consumo, digestibilidade, produção e composição do leite de vacas Holandesas primíparas.

The objective with the current study was to evaluate the effects of a commercial mixture of essential oils (capsaicin, eugenol, cinnamaldehyde, and carvacrol) microencapsulated with increasing inclusions (0, 1.5, 3.0 and 4.0g/day) on intake, digestibility, performance and milk composition of 20 primiparous Holstein cows confined in sand-bedded stalls. There was no interaction between treatment and observation periods, and the effect of treatments was not significant (P>0,05) for dry matter intake, expressed as % body weight (BW) and kg/day; crude protein (% BW); ether extract (% BW); neutral detergent fiber; acid detergent fiber (% BW); dry matter digestibility (%); crude protein (%); ether extract (%); neutral detergent fiber (%); milk production (kg); milk fat (%); milk protein (%); lactose (%); total solids (%); nonfat dry extract (%); somatic cell count (log); and urea nitrogen (mg/dL). However, evaluating each period, a significant decrease (P<0,05) on milk production, and an increase in total solids concentrations (%) were observed. There was no difference (P>0,05) for total solids levels (%) and somatic cell count (log). We concluded that the use of essential oils containing capsaicin, eugenol, cinnamaldehyde and carvacrol does not affect intake, digestibility, and milk production and composition of primiparous Holstein cows.