Abstract This study examined the relationship between age at first calving and milk production in Holstein heifers within an intensive system in the dairy basin of Córdoba, Argentina. Retrospective data from 452 cows calving between 2016 and 2017, aged between 23 and 32 months, were collected. The results revealed a significant decrease in adjusted 305-day milk yield as age at first calving increased. Cows calving at 24 months yielded higher total milk production by the end of lactation compared to those calving at 31 and 32 months. A significant difference in daily milk yield during lactation was observed based on age at first calving, while no significant effect of calving year was found. Total daily milk yield was also influenced by age at first calving, with cows calving at 24 months exhibiting higher production compared to those calving at 32 months. The dry period, representing the days from drying off to the start of the subsequent lactation, was also influenced by age at first calving, with significant differences observed between cows calving at 23 and 31 months, as well as at 24 and 31 months. In terms of reproductive variables, a significant difference in the calving interval was found based on age at first calving. No significant interaction between age at first calving and calving year was identified for any of the analyzed variables. In conclusion, this study demonstrated that age at first calving has a significant impact on milk production in Holstein cows within an intensive system. The findings suggest that placing greater emphasis on achieving first calving between 23 and 25 months of age may enhance productive and reproductive efficiency in dairy farms.

Resumen Este estudio analizó la relación entre la edad al primer parto y la producción de leche en vacas Holstein en un sistema intensivo en la cuenca lechera de Córdoba, Argentina. Se recopilaron datos retrospectivos de 452 vacas que parieron entre 2016 y 2017, con edades comprendidas entre 23 y 32 meses. Los resultados mostraron que a medida que la edad al primer parto aumenta, la producción de leche ajustada a los 305 días disminuye significativamente. Las vacas que parieron a los 24 meses produjeron más leche total al final de la lactancia en comparación con aquellas que parieron a los 31 y 32 meses. Se observó una diferencia significativa en la producción diaria de leche en lactancia según la edad al primer parto, pero no se encontró un efecto significativo del año de parto. La producción diaria total de leche también fue afectada por la edad al primer parto, con las vacas que parieron a los 24 meses mostrando una mayor producción en comparación con las que parieron a los 32 meses. El período seco, que representa los días desde el secado hasta el inicio de la próxima lactancia, también fue influenciado por la edad al primer parto, con diferencias significativas entre las vacas que parieron a los 23 y 31 meses, y a los 24 y 31 meses. En cuanto a las variables reproductivas, se encontró una diferencia significativa en el intervalo entre partos según la edad al primer parto. No se encontró una interacción significativa entre la edad al primer parto y el año de parto para ninguna de las variables analizadas. En conclusión, este estudio demostró que la edad al primer parto tiene un impacto significativo en la producción de leche de vacas Holstein en un sistema intensivo. Los resultados sugieren que un mayor énfasis en alcanzar un primer parto a una edad entre los 23 y 25 meses podría mejorar la eficiencia productiva y reproductiva en las explotaciones lecheras.

Resumen Introducción: La confiabilidad de la presión sistólica arterial pulmonar por ecocardiografía transtorácica se encuentra limitada por su variabilidad para definir la hipertensión pulmonar. Objetivo: Conocer la variabilidad en la presión sistólica arterial pulmonar estimada por ecocardiografía en la hipertensión pulmonar. Métodos: En el periodo 2016-2020 se captaron sujetos con hipertensión pulmonar que tuvieron estimada la presión sistólica de la arteria pulmonar por ecocardiografía transtorácica y por cateterismo cardiaco derecho. Se obtuvieron sus variables demográficas. Los datos se analizaron con el estadístico descriptivo de Bland-Altman y el coeficiente de correlación intraclase (intervalo de confianza al 95%). Resultados: Se estudiaron 152 sujetos, edad 60 ± 12 años. Índice de masa corporal 27.64 ± 4.69 kg/m2. La presión sistólica de la arteria pulmonar por ecocardiografía transtorácica 58.99 ± 18.62 vs. cateterismo cardiaco 55.43 ± 16.79. Diferencia media (sesgo) –3.6 (29.1, –36.2) y coeficiente de correlación intraclase 0.717 (0.610, 0.794). Conclusiones: La variabilidad es amplia y el acuerdo es sustancial con la presión sistólica de la arteria pulmonar. Se aconseja estimarla solo como tamizaje de la hipertensión pulmonar.

Abstract Introduction: The reliability of pulmonary arterial systolic pressure by transthoracic echocardiography is limited by its variability to define pulmonary hypertension. Objective: To know the variability of pulmonary arterial systolic pressure estimated by echocardiography in pulmonary hypertension. Their demographic variables were obtained. Methods: From 2016-2020 subjects with pulmonary hypertension were recruited, with pulmonary artery systolic pressure estimated by transthoracic echocardiography and by right heart catheterization. Data were analyzed using the Bland-Altman descriptive statistic and the intraclass correlation coefficient (95% confidence interval). Results: 152 subjects, age 60 ± 12 years, were studied. Body mass index 27.64 ± 4.69 kg/m2. The pulmonary artery systolic pressure estimated by transthoracic echocardiography 58.99 ± 18.62 vs. cardiac catheterization 55.43 ± 16.79 mmHg. Mean difference (bias) –3.6 (29.1, –36.2) and intraclass correlation coefficient 0.717 (0.610, 0.794). Conclusions: Variability is wide, and agreement is substantial for pulmonary artery systolic pressure. It is recommended to estimate only as screening for pulmonary hypertension.

While international conventions with a gender perspective exist, at national level countries such as Mexico have also developed policies and programmes in favour of women's access to a life of equality and free of violence. Such policies have been translated into institutional protocols to curb gender violence. Despite these polices, data seem to indicate that violence against women continues (UN Women 2020) and gender inequality persists. This article explores the significance of a social gender activist movement that began in 2019 called "clothesline complaints" in one of the most prestigious universities in Mexico. The article also seeks to assess the impact of this movement in other institutions using a documentary analysis research approach. Results show that the selected institutions reported a large number of complaints regarding gender violence. The article concludes that by adopting unconventional grievances reporting procedures of the "clothesline" rather than the traditional institutional protocols, more cases of gender violence can be revealed. We recommend the adoption of the clothesline approach as well as other novel ways of reporting gender-based violence. The clothesline movement presents an opportunity to re-examine the current gender violence reporting structure in higher education institutions in Mexico. Because of the global nature of gender-based violence, we also consider implications for policy and structural review of gender violence reporting protocols in South Africa and other parts of the world. Of key significance is how to integrate informal gender-based violence reports into the formal protocols of reporting without diminishing the original force of appeal which animate the informal reports.

Resumen El modelo dimensional alternativo para los trastornos de personalidad incluye 25 facetas (rasgos patológicos) organizadas en cinco dominios de orden superior (Desapego, Afectividad Negativa, Psicoticismo, Antagonismo y Desinhibición). Para evaluar este modelo, se desarrolló el Personality Inventory for DSM-5 (PID-5), que posee dos versiones: una extensa (220 ítems) que evalúa dominios y facetas, y una breve (25 ítems) que evalúa solo los dominios. En un trabajo anterior, se brindó evidencia favorable para una versión breve (31 ítems) adaptada para ser utilizada en población argentina. En el presente trabajo se estudian las propiedades psicométricas de una versión reducida y modificada del PID-5 que permite evaluar ambos componentes por medio de una cantidad de ítems (108). La validez convergente se evaluó a través de la relación con una medida de rasgos de personalidad normal del Modelo de los Cinco Grandes Factores. Se trabajó con una muestra de tipo no probabilística de n = 525 sujetos de población general, que respondieron la versión adaptada del PID-5 y el Listado de Adjetivos para Evaluar la Personalidad. Los resultados brindaron evidencia de validez y confiabilidad para el instrumento. El Análisis Factorial Exploratorio y Confirmatorio sugirió un buen ajuste de la estructura pentafactorial. La consistencia interna resultó adecuada y los ítems presentaron buenos índices de discriminación. Se observaron diferencias de género y edad, y correlaciones con los factores correspondientes de los cinco grandes. Esta versión puede ser utilizada para evaluar el modelo, con fines tanto clínicos como de investigación, y con ventajas respecto al tiempo de administración respecto a la versión extensa original.

Abstract The official classification of personality disorders in the latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) remains categorical. However, a dimensional alternative for personality disorders is presented as an emerging model. The model is organized in five higher order domains (Negative Affectivity, Detachment, Antagonism, Disinhibition and Psychoticism), with relationships with the Big Five Model of Personality, strongly established within the Personality Psychology. The proposal also includes 25 facets or second-order traits, included within the main domains. Domains and facets represent psychopathological traits with clinical relevance. To assess this model, the Personality Inventory for DSM-5 (PID-5) was developed. PID-5 has two forms: extensive (220 items) that assesses domains and facets, and brief (25 items) that assesses only the domains. In a previous study, evidence for a short version (31 items) adapted to the Argentine population was provided, that overcomes some of the limitations of the original one. In this work, the psychometric properties of a reduced and modified version of the PID-5 are studied, which allows evaluating five domains and 25 facets, through a reduced number of items (108). We worked with a non-probabilistic sample of n = 525 subjects from the general population, who answered the adapted version of the PID-5 and the Adjectives Checklist to Assess the Big Five Personality Factors (AEP), a Big Five Model measure. The following data analyses were performed: (1) Exploratory and Confirmatory Factor Analysis to evaluate the internal structure of PID-5; (2) reliability analysis to assess the internal consistency of the PID-5 scales; (3) item analysis to assess discriminating power; (4) multivariate analysis of variance (MANOVA) to examine significant differences due to gender and age; and (5) bivariate correlation analysis to analyze PID-5 convergent validity. The results provided evidence of validity and reliability. Exploratory and Confirmatory Factor Analysis suggested a five-factor structure. The facets presented factor loadings in the domain theoretically expected, with some exceptions: Suspiciousness (loaded in Psychoticism), Hostility (loaded in Disinhibition), Depressivity (loaded in Detachment) and Insensitivity (loaded in Detachment). CFA also suggested a good model fit (CFI = .98; RMSEA = .04; SRMR = 0.083). Psychoticism, Detachment, and Disinhibition facets had their higher factor loadings in the expected domain. Negative affectivity showed higher correlations with the rest of the scales. Internal consistency was satisfactory, especially at the domain level, and the items had good discrimination indices. Correlations with the corresponding of the Big Five factors were observed, similar to previous studies. The five PID-5 domains were also found positively correlated. Additionally, gender and age differences were found. In line with previous literature, results suggest that some facets scales are “pure” markers of these domains (e. g., Psychoticism and Antagonism facets), whereas others (e. g., Negative Affectivity facets such as Depressiveness, Suspicion, Hostility), are located “in between” domains since they share features of more than one domain. Psychoticism facets presented higher loadings in their domains and lower in the rest. This is not surprising; although most of psychopathology cannot be understood as categories, schizophyte and Schizotypal Personality Disorder are exceptions, and Psychoticism would be the representation of these categories in the APA model. Findings also provide evidence of convergent validity for the instrument, as well as theorical evidence regarding the relationship between normal and pathological personality traits. This version can be used to evaluate the model, both in research and clinical practice. It has advantages over the original longer version, in terms of administration time and participants' fatigue, while maintaining its psychometric properties. The results are also expected to contribute to the recent literature on the dimensional approach to personality psychopathology. However, complementary studies, particularly with a clinical population, are needed.

Resumen Las comunidades de anuros y los componentes bióticos asociados, así como el hábitat físico circundante varían entre regiones. El éxito de las investigaciones sobre biodiversidad de anfibios dependerá entonces de conocer la eficiencia de las diferentes técnicas de muestreo que se aplican en cada ambiente particular que es analizado. En este contexto, evaluamos la efectividad relativa de registro (ERR) de cuatro técnicas diferentes en un humedal lacustre localizado en la Reserva Juan Bautista Alberdi (RJBA), en el centro-este de Argentina. Se efectuaron los relevamientos de diciembre de 2021 a marzo de 2022 (temporada de verano), sumándose un muestreo de otoño (mayo/2022). Se emplearon a) trampas de caída, b) muestreos de larvas con red, c) transectas de prospección auditiva y d) transectas de prospección visual. En cada caso, se calculó la ERR estandarizando los registros de acuerdo al esfuerzo de muestreo medido en minutos. Para estudiar el efecto de la técnica de muestreo sobre la ERR se realizó un modelo lineal randomizado mediante un test de permutación, aplicando 1,000 iteraciones. Se registraron un total de 11 especies, siendo Boana pulchella, Scinax nasicus y Rhinella dorbignyi las detectadas con mayor frecuencia. La técnica de muestreo influyó en la ERR (P = 0.001). El transecto de prospección auditiva resultó la técnica más exitosa, con una ERR del 24.44%, seguida por la búsqueda de larvas con red (3.70%) y el transecto de prospección visual (3.38%). No obstante, estas dos últimas permitieron encontrar especies no detectadas con la primera. Consecuentemente, un diseño integrando diferentes técnicas es necesario para estudiar adecuadamente las comunidades de anfibios de la RJBA. Mejorar la efectividad de los muestreos permite fortalecer nuestra comprensión sobre la biodiversidad de este grupo taxonómico, tan necesario en el contexto de declinación global actual.

Abstract Anuran communities and their associated biotic components, as well as the surrounding physical habitat, vary between regions. The success of research on amphibian biodiversity will then depend on knowing the efficiency of the different sampling techniques that are applied in each particular environment analyzed. In this context, we evaluated the relative registration effectiveness (RRE) of four different techniques in a lacustrine wetland located in the Juan Bautista Alberdi Reserve (JBAR), in east -central Argentina. Research was carried out from December 2021 to March 2022 (summer season), adding an autumn sampling (May/2022). Techniques used were: A) pitfall traps, b) larval sampling, c) acoustic survey transects and d) visual survey transects. In each case, the RRE was calculated by standardizing the records according to the sampling effort measured in minutes. To study the effect of the sampling technique on RRE, a randomized linear model was created using a permutation test, applying 1,000 iterations. A total of 11 species were recorded, with Boana pulchella, Scinax nasicus and Rhinella dorbignyi being the most frequently detected. The sampling technique was found to influence RRE (P = 0.001). The acoustic survey transect was the most successful technique, with an RRE of 24.44%, followed by the search for larvae with a net (3.70%) and the visual survey transect (3.38%). However, these last two allowed us to find species not detected by the first technique. Consequently, a design integrating different techniques is necessary to adequately study the amphibian communities of the JBAR. Improving the effectiveness of sampling allows us to strengthen our understanding of the biodiversity of this taxonomic group, which is so necessary in the context of current global decline.

RESUMO Lagartas de Automeris liberia (Lepidoptera: Saturniidae) são importantes desfolhadoras da palma de óleo, Elaeis guineensis (Arecaceae) nas Américas Central e do Sul. A família Tachinidae (Diptera) compreende moscas parasitoides de muitos insetos-praga, principalmente da ordem Lepidoptera. Contudo, o registro de hospedeiros de taquinídeos ainda é relativamente escasso. No presente trabalho, relatamos a ocorrência de Belvosia sp. aff. williamsi (Diptera: Tachinidae: Exoristinae: Goniini) e Leptostylum oligothrix (Diptera: Tachinidae: Exoristinae: Blondeliini) parasitando lagartas de A. liberia em E. guineensis no município de Tailândia, Pará, Brasil. Trata-se do primeiro registro do parasitismo de A. liberia por Leptostylum no Brasil, bem como o primeiro por Belvosia no mundo. Lepidoptera (Lepidoptera Saturniidae óleo Arecaceae (Arecaceae Sul Diptera (Diptera insetospraga, insetospraga insetos praga, praga insetos-praga Contudo escasso trabalho sp aff Exoristinae Goniini Blondeliini E Tailândia Pará Brasil Tratase Trata se mundo

ABSTRACT Automeris liberia (Lepidoptera: Saturniidae) caterpillars are important defoliators of the African oil palm, Elaeis guineensis (Arecaceae) in Central and South America. The family Tachinidae (Diptera) comprises flies that are parasitoids of many insect pests, mainly from the order Lepidoptera. However, host records for tachinids are still relatively scarce. In the present work, we report the occurrence of Belvosia sp. aff. williamsi (Diptera: Tachinidae: Exoristinae: Goniini) and Leptostylum oligothrix (Diptera: Tachinidae: Exoristinae: Blondeliini) parasitizing caterpillars of A. liberia in E. guineensis in the municipality of Tailândia, state of Pará, Brazil. This is the first record of the parasitism of A. liberia by Leptostylum in Brazil, as well as by Belvosia in the world. Lepidoptera (Lepidoptera Saturniidae palm Arecaceae (Arecaceae America Diptera (Diptera pests However scarce work sp aff Exoristinae Goniini Blondeliini A E Tailândia Pará Brazil world

ABSTRACT The effectiveness of the Bacillus subtilis and Pseudomonas donghuensis strains for the control of Fusarium oxysporum and Pythium aphanidermatum, which cause the drowning of chili seedlings in the greenhouse, was evaluated. Its pathogenicity to cause the disease was verified and antagonism tests were obtained in culture plates with enriched PDA. Through the in vitro confrontation of these phytopathogens with three strains of the species Bacillus subtilis, it was observed that this sporulate has the capacity to inhibit to a greater or lesser degree (39.35- 56.24 %) the mycelial growth of F. oxysporum, but not the from P. aphanidermatum, none of the Bacillus isolates used in this study had an effect in inhibiting this Oomycete, since it grew faster than the spore-forming bacteria, since P. aphanidermatum developed and grew to fill the culture plate in just 36 hours. On the other hand, P. donghuensis inhibited the growth of this last phytopathogen by 56 %, however, it did not present an inhibition effect against F. oxysporum, so it could be feasible to use mixtures of these two antagonists for the management of this disease and be able to control Damping off problems caused by these phytopathogens.

RESUMEN Se evaluó la efectividad de Pseudomonas donghuensis y Bacillus subtilis para el control de Fusarium oxysporum y Pythium aphanidermatum causantes del ahogamiento de plántulas de chile en invernadero. Se comprobó su patogenicidad para ocasionar la enfermedad y se realizaron pruebas de antagonismo en placas con PDA enriquecido. Mediante la confrontación in vitro de estos fitopatógenos con tres cepas de Bacillus subtilis se comprobó que este esporulado inhibió en mayor o menor grado (39.35- 56.24 %) el crecimiento micelial de F. oxysporum, pero no tuvo efecto alguno para P. aphanidermatum, ningún Bacillus inhibió a este Oomycete, debido a su rápido crecimiento en la placa de cultivo (36 h de incubación). En contraste P. donghuensis inhibió en un 56 % el crecimiento de P. aphanidermatum, y no presentó efecto inhibitorio para F. oxysporum, por lo que la mezcla de ambos antagonistas pudiera tener potencial para el control de los problemas de ahogamiento ‘‘Damping off” causados por estos fitopatógenos.

Abstract This paper aims to study the determinants of the governance model of water resources in the agriculture of the Hermosillo-Coast (Mexico). To achieve this objective, a literature review, in-depth interviews and a workshop were carried out. The results show that the main threats to the system come from the model of granting concessions for access to water resources, the lack of supervision by the competent authority and the control of a group of stakeholders over water in relation to the rest of the interested parties. Finally, measures aimed at improving the sustainability of agricultural activity in the area are proposed.

Resumo Para analisar a cobertura telejornalística da pandemia de COVID-19 nas prisões brasileiras e sua visibilidade, foram examinadas 213 matérias veiculadas entre março e dezembro de 2020, encontradas no serviço de buscas da plataforma digital de vídeos por streaming Globoplay. A maior parte foi ao ar em março, abril e julho, com importante redução nos meses subsequentes. As reportagens, sobre números de mortes ou infectados, medidas de prevenção e prisão domiciliar ou liberdade para grupos de risco da COVID-19, foram divulgadas principalmente nos jornais locais. Os órgãos de saúde quase não foram ouvidos. Das 19 notícias apresentadas nacionalmente, 12 abordam os “presos famosos” e a legitimidade da prisão domiciliar ou a liberdade para grupos de risco da COVID-19. As pautas sanitárias e de garantia do direito à saúde das pessoas privadas de liberdade ficaram limitadas às dificuldades para a efetivação nos presídios das medidas de proteção e a sustentar a necessidade de medidas restritivas à movimentação no interior das prisões e nos intercâmbios com o exterior para limitar a circulação do vírus. Em geral, a forma e a visibilidade dadas ao tema não contribuem para ampliar a percepção dos telespectadores sobre as condições sanitárias das prisões e o fato de que a saúde é um direito de todos, sem qualquer distinção.

Abstract To analyze the news coverage of the COVID-19 pandemic in Brazilian prisons and its visibility, 213 articles broadcast between March and December 2020 were examined, found in the search service of the digital streaming video platform Globoplay. Most aired in March, April and July, with the theme almost disappearing in subsequent months. The reports, on numbers of deaths or infections, prevention measures and house arrest or freedom for groups at risk of COVID-19 were mainly published in local telejournals. Health agencies were barely heard. Of the 19 news items presented nationally, 12 address “famous prisoners” and the legibility of house arrest or freedom for groups at risk of COVID-19 unfavorable outcome. The health guidelines and the guarantee of the right to health of persons deprived of liberty were limited to the difficulties in implementing protection measures in prisons and to sustaining the need for restrictive measures to move inside prisons and in exchanges with the outside, to limit the circulation of the virus. In general, the form and visibility given to the topic do not contribute to broadening the viewers’ perception of the sanitary conditions in prisons and the fact that health is a right for all, without any distinction.

Abstract To analyze the news coverage of the COVID-19 pandemic in Brazilian prisons and its visibility, 213 articles broadcast between March and December 2020 were examined, found in the search service of the digital streaming video platform Globoplay. Most aired in March, April and July, with the theme almost disappearing in subsequent months. The reports, on numbers of deaths or infections, prevention measures and house arrest or freedom for groups at risk of COVID-19 were mainly published in local telejournals. Health agencies were barely heard. Of the 19 news items presented nationally, 12 address “famous prisoners” and the legibility of house arrest or freedom for groups at risk of COVID-19 unfavorable outcome. The health guidelines and the guarantee of the right to health of persons deprived of liberty were limited to the difficulties in implementing protection measures in prisons and to sustaining the need for restrictive measures to move inside prisons and in exchanges with the outside, to limit the circulation of the virus. In general, the form and visibility given to the topic do not contribute to broadening the viewers’ perception of the sanitary conditions in prisons and the fact that health is a right for all, without any distinction.

Resumo Para analisar a cobertura telejornalística da pandemia de COVID-19 nas prisões brasileiras e sua visibilidade, foram examinadas 213 matérias veiculadas entre março e dezembro de 2020, encontradas no serviço de buscas da plataforma digital de vídeos por streaming Globoplay. A maior parte foi ao ar em março, abril e julho, com importante redução nos meses subsequentes. As reportagens, sobre números de mortes ou infectados, medidas de prevenção e prisão domiciliar ou liberdade para grupos de risco da COVID-19, foram divulgadas principalmente nos jornais locais. Os órgãos de saúde quase não foram ouvidos. Das 19 notícias apresentadas nacionalmente, 12 abordam os “presos famosos” e a legitimidade da prisão domiciliar ou a liberdade para grupos de risco da COVID-19. As pautas sanitárias e de garantia do direito à saúde das pessoas privadas de liberdade ficaram limitadas às dificuldades para a efetivação nos presídios das medidas de proteção e a sustentar a necessidade de medidas restritivas à movimentação no interior das prisões e nos intercâmbios com o exterior para limitar a circulação do vírus. Em geral, a forma e a visibilidade dadas ao tema não contribuem para ampliar a percepção dos telespectadores sobre as condições sanitárias das prisões e o fato de que a saúde é um direito de todos, sem qualquer distinção.

RESUMEN Introducción: La espondiloartritis axial es una enfermedad reumatológica que afecta a individuos jóvenes y tiene una gran repercusión sociolaboral. El retraso en el diagnóstico y el tratamiento se asocia con un mayor deterioro funcional y un impacto negativo en la calidad de vida, por lo que requiere un abordaje multidisciplinario. Objetivo: Desarrollar y formular un conjunto de recomendaciones específicas basadas en la mejor evidencia disponible para la detección temprana, el diagnóstico, el tratamiento y el seguimiento de los pacientes adultos con espondiloartritis axial. Métodos: Se configuró un grupo desarrollador, se formularon preguntas clínicas contestables, se graduaron los desenlaces y se realizó la búsqueda sistemática de la evidencia. El panel de la guía fue multidisciplinario (incluyendo representantes de los pacientes) y balanceado, minimizando el sesgo por conflictos de intereses. Se utilizó la aproximación Grading of Recommendations Assessment, Development and Evaluation (GRADE) para evaluar la calidad de la evidencia, al igual que la dirección y la fortaleza de las recomendaciones. Se presentan 11 recomendaciones relacionadas con diagnóstico (n = 2), tratamiento farmacológico (n = 6), tratamiento no farmacológico (n = 2) y seguimiento (n = 1). Resultados: Se recomienda la radiografía de articulaciones sacroilíacas como primer método diagnóstico, y el uso de escalas de actividad para el seguimiento de los pacientes (ASDAS o BASDAI). Los antiinflamatorios no esteroideos son la primera opción de tratamiento; en caso de intolerancia o dolor residual se recomienda acetaminofén u opioides. En pacientes con compromiso axial se recomienda abstenerse de utilizar medicamentos antirreumáticos modificadores de la enfermedad convencionales ni glucocorticoides sistémicos o locales. En pacientes con falla a los antiinflamatorios no esteroideos, se recomienda un anti-TNFα o un anti-IL17A. En pacientes con falla a anti-TNFα, se recomienda iniciar un anti-IL17A. El ejercicio y la terapia física y ocupacional se recomiendan como parte del tratamiento. Se recomienda no utilizar las terapias no convencionales como única opción de tratamiento. Conclusiones: Este conjunto de recomendaciones proporciona una guía actualizada sobre el diagnóstico y el tratamiento de la espondiloartritis axial.

Abstract Introduction: Axial spondyloarthritis is a rheumatic condition affecting young patients with social and occupational consequences. Diagnosis delay is associated with functional impairment and impact on quality of life, requiring a multidisciplinary approach. Objective: To develop a set of recommendations based on the best available evidence for the early detection, diagnosis, treatment, and monitoring of adult patients with axial spondy-loarthritis. Methods: A working group was established, questions were developed, outcomes were graded, and a systematic search for evidence was conducted. A multidisciplinary panel of members was established (including patient representatives), minimizing bias in relation to conflicts of interest. The GRADE approach "Grading of Recommendations Assessment, Development and Evaluation" was used to assess the quality of the evidence as well as the direction and strength of recommendations. In total, 11 recommendations on diagnosis (n=2), pharmacological treatment (n=6), non-pharmacological treatment (n=2) and monitoring (n=1) are presented. Results: Sacroiliac joint radiography as the first diagnostic method, and the use of disease activity scales for patient monitoring (ASDAS or BASDAI), are recommended. Nonsteroidal anti-inflammatory drugs are the first treatment option; in case of intolerance or residual pain, acetaminophen or opioids are recommended. In patients with axial involvement, it is recommended not to use conventional disease-modifying antirheumatic drugs or systemic or local glucocorticoids. In patients with failure to non-steroidal anti-inflammatory drugs, anti-TNF or anti-IL17A are recommended. In those patients presenting with anti-TNF failure, starting an anti-IL17A is recommended. Exercise, physical and occupational therapy are recommended as part of treatment. It is recommended not to use unconventional therapies as the only treatment option. Conclusions: This set of recommendations provides an updated guideline for the diagnosis, treatment, and monitoring of patients with axial spondyloarthritis.

Resumo O Questionário revisado de bullying de Olweus (rBVQ) é um instrumento internacionalmente utilizado para identificar bullying, mas devido às dificuldades de estudantes brasileiros na leitura e escrita, foi adaptado para uso áudio-guiado em smartphones. Investigou-se a validade do construto por meio de análise confirmatória fatorial em uma solução de dois fatores. Participaram 1742 e 2316 alunos de quintos e sétimos anos de trinta escolas públicas de São Paulo. Encontrou-se excelentes índices de adequação para ambos os anos escolares (quintos: CFI = 0,985; RMSEA = 0,020; sétimos: CFI = 0,990; RMSEA = 0,015) e cargas fatoriais maiores que 0,4 para todos os itens, indicando sua relevância para o construto. O rBVQ demonstrou excelentes propriedades psicométricas e pode ajudar estudos futuros que objetivam investigar bullying em populações com perfis semelhantes. Além disso, este estudo inova por avaliar um instrumento áudio-guiado e utilizando tecnologia móvel.

Abstract The revised Olweus Bully/Victim Questionnaire (rBVQ) is an internationally used instrument to identify bullying, but due to Brazilian students’ low proficiency in reading and writing, it had to be adapted for audio-guided use through smartphones. We investigated construct validity, using Confirmatory Factor Analysis (CFA), under a two-correlated factor solution. Participated 1,742 fifth graders and 2,316 seventh graders from 30 public schools in the city of São Paulo. We found excellent fit indices models for both grades (fifth grade: CFI=0.985, RMSEA=0.020; seventh grade: CFI=0.990, RMSEA=0.015), as well as factor loading higher than 0.4 for all items, indicating their relevance to the construct. The rBVQ demonstrated excellent psychometric properties and may help future studies that aim to investigate bullying in populations with similar profiles. In addition, this study innovates by evaluating an audio-guided instrument and using mobile technology.

Resumen El Cuestionario Revisado de Bullying de Olweus (rBVQ) es un instrumento utilizado internacionalmente para identificar bullying, pero debido a las dificultades de estudiantes brasileños en la lectura y la escritura, se ha adaptado su uso por medio de audioguías en smartphones. Se investigó la validez del constructo mediante el Análisis Factorial Confirmatorio, bajo un modelo de dos factores. Participaron 1742 y 2316 estudiantes de quinto y séptimo curso de 30 escuelas públicas de São Paulo. Excelentes tasas de adecuación fueron encontradas para ambos casos (quinto año: CFI=0,985, RMSEA=0,020; séptimo año: CFI=0,990, RMSEA=0,015), además de cargas factoriales superiores a 0,4 para todos los ítems, lo que indica su relevancia para el constructo. El instrumento rBVQ ha presentado excelentes propiedades psicométricas y puede ayudar a futuros estudios pretendan investigar el bullying en poblaciones con perfiles similares. Además, este estudio innova al evaluar un instrumento guiado por audio, empleando la tecnología móvil.

Introduction: It has been postulated the relationship between presence of cardiometabolic diseases with mental health problems, particularly depression. Objectives: To determine the association between cardiometabolic diseases and presence of depressive symptoms, evaluated by PHQ-9 questionnaire, in patients attended at the outpatient clinic of internal medicine service at Hospital Nacional Hipolito Unanue. Methods: Observational analytical cross-sectional study. Cardiometabolic disease was defined as the presence of diabetes mellitus, high blood pressure, dyslipidemia, and/or obesity. The PHQ-9 questionnaire was used to evaluate the presence of symptoms suggestive of depression. The association was evaluated crude and adjusted for possible confounders. For the multivariate analysis, a Poisson regression model was used to find prevalence ratios with their respective 95% confidence intervals. A p<0.05 was considered statistically significant. Results: 252 patients were included, of which 205 (81,4%) presented cardiometabolic diseases and 181 (71,9%) presented symptoms consistent with some grade of depression. The presence of cardiometabolic diseases was associated with depressive symptoms both in the crude analysis (PRc 1.43; CI 95% 1.08-1.89; p=0.012) and in the adjusted one (PRa 1.31; CI 95% 1.00-1.71; p=0.048). Additionally, an association was found between female sex and depressive symptoms (PRa 1,35; CI 95% 1,11-1,63; p=0,002). Conclusions: The presence of cardiometabolic diseases was associated with the presence of depressive symptoms in patients seen at the outpatient clinic of internal medicine. The mental health approach should be an integral part of the multidisciplinary management for the patient with cardiometabolic disease.

Resumen Introducción: Se ha postulado la relación entre la presencia de enfermedades cardiometabólicas con problemas de salud mental, en particular la depresión. Objetivos: Determinar la asociación entre la presencia de enfermedades cardiometabólicas y la presencia de sintomatología depresiva evaluada mediante el cuestionario PHQ-9 en pacientes atendidos en consultorios externos de medicina interna del Hospital Nacional Hipólito Unanue. Metodología: Estudio observacional, analítico, transversal. Se definió enfermedad cardiometabólica como la presencia de diabetes mellitus, hipertensión arterial, dislipidemia, y/u obesidad. Se utilizó el cuestionario PHQ-9 para evaluar la presencia de síntomas sugerentes de depresión. Se evaluó la asociación cruda y ajustada a posibles confusores. Para el análisis multivariado se utilizó un modelo de regresión de Poisson para hallar razones de prevalencia con sus respectivos intervalos de confianza al 95%. Se consideró un p<0,05 como estadísticamente significativo. Resultados: Se incluyeron 252 pacientes, de los que 205 (81,4%) presentaron enfermedades cardiometabólicas y 181 (71,9%) presentaron síntomas consistentes con algún grado de depresión. La presencia de enfermedades cardiometabólicas se asoció a síntomas depresivos tanto en el análisis crudo (RPc 1,43; IC 95% 1,08-1,89; p=0,012) como en el ajustado (RPa 1,31; IC 95% 1,00-1,71; p=0,048). Adicionalmente se encontró asociación entre el sexo femenino y sintomatología depresiva (RPa 1,35; IC 95% 1,11-1,63; p=0,002). Conclusiones: La presencia de enfermedades cardiometabólicas se asoció con la presencia de síntomas depresivos en pacientes atendidos en la consulta externa de medicina interna. El abordaje de la salud mental debe ser parte integral del manejo multidisciplinario del paciente con enfermedad cardiometabólica.

This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of their ability to inhibit some in vitro (coagulant, proteolytic and hemolytic) and in vivo (hemorrhagic, edematogenic and lethality) toxic activities of Bothrops jararaca and Bothrops jararacussu venoms. Compounds have been synthesized from the coupling of intermediate 5-amino-6 methoxybenzo[d][1,3]oxathiol-2-one 4 with benzenesulfonyl chlorides. Characterization of the products was achieved by nuclear magnetic resonance (NMR) and electrospray ionization mass spectra (ESI-MS) techniques. Biological assay results have shown that most of compounds inhibited the main toxic activities of the venom of the two snake species. Compound 5b (N-(6 methoxy-2 oxobenzo[d][1,3]oxathiol-5-yl)-4-nitrobenzenesulfonamide) was the most efficient in inhibiting hemolysis of B. jararaca, and coagulation and proteolysis induced by both venoms. For in vivo activities, all compounds inhibited the edema, from 35 to 72%, and most of them exhibited antihemorrhagic and antilethality activities. Thus, the results pointed to the biological potential of these compounds, being promising molecules to treat envenomation by these snakes as well as to aid the current antivenom serum therapy.

RESUMEN Objetivo. Resumir los resultados de las investigaciones realizadas en Costa Rica en las que se aplicaron métodos matemáticos y estadísticos para estudiar la dinámica de transmisión de las enfermedades transmitidas por mosquitos. Métodos. Se seleccionaron y analizaron tres artículos con análisis matemáticos y estadísticos sobre enfermedades transmitidas por vectores en Costa Rica. En estos artículos se muestra el valor y la pertinencia de emplear diferentes métodos cuantitativos para comprender la dinámica de la enfermedad y brindar apoyo a la toma de decisiones. Resultados. Los resultados de estas investigaciones: 1) muestran la repercusión en los informes de casos de dengue cuando surge un segundo agente patógeno, como el chikunguña; 2) recuperan parámetros clave en la dinámica del Zika mediante la inferencia bayesiana; y 3) muestran el uso de los algoritmos de aprendizaje automático y las variables climáticas para pronosticar el riesgo relativo de dengue en cinco lugares diferentes. Conclusiones. Los modelos matemáticos y estadísticos permiten describir la dinámica de transmisión de las enfermedades transmitidas por mosquitos, mediante la provisión de información cuantitativa para brindar apoyo a los métodos de prevención y control y a la planificación de la asignación de recursos.

ABSTRACT Objective. To summarize the results of research conducted in Costa Rica in which mathematical and statistical methods were implemented to study the transmission dynamics of mosquito-borne diseases. Methods. Three articles with mathematical and statistical analysis on vector-borne diseases in Costa Rica were selected and reviewed. These papers show the value and relevance of using different quantitative methods to understand disease dynamics and support decision-making. Results. The results of these investigations: 1) show the impact on dengue case reports when a second pathogen emerges, such as chikungunya; 2) recover key parameters in Zika dynamics using Bayesian inference; and 3) show the use of machine learning algorithms and climatic variables to forecast the dengue relative risk in five different locations. Conclusions. Mathematical and statistical modeling enables the description of mosquito-borne disease transmission dynamics, providing quantitative information to support prevention/control methods and resource allocation planning.

RESUMO Objetivo. Resumir os resultados de estudos realizados na Costa Rica em que foram aplicados métodos matemáticos e estatísticos para estudar a dinâmica de transmissão de doenças transmitidas por mosquitos. Métodos. Foram selecionados e revisados três artigos com análises matemáticas e estatísticas sobre doenças transmitidas por vetores na Costa Rica. Esses artigos mostram o valor e a pertinência do uso de diferentes métodos quantitativos para compreender a dinâmica das doenças e apoiar a tomada de decisões. Resultados. Os resultados dessas investigações: 1) mostram o impacto nas notificações de casos de dengue quando surge um segundo patógeno, como o chikungunya; 2) recuperam parâmetros-chave na dinâmica do zika, usando a inferência bayesiana; e 3) mostram o uso de algoritmos de aprendizagem por máquina e variáveis climáticas para prever o risco relativo da dengue em cinco locais diferentes. Conclusões. A modelagem matemática e estatística permite a descrição da dinâmica de transmissão de doenças transmitidas por mosquitos ao oferecer informações quantitativas para apoiar métodos de prevenção e/ou controle e o planejamento da alocação de recursos.