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Abstract Objective: this study aimed to evaluate if there is an association of intake of coffee and its polyphenols with mammographic findings in women treated at a breast care service unit of the Unified Health System (SUS), Brazil. Research methods and procedures: this was a cross-sectional study with 532 women treated at a health service. The participants were divided according to their mammographic reports into two groups: without and with altered findings. Two 24-h dietary recalls were applied and coffee consumption was categorized into three groups (less than 1 cup, 1 to 3 cups, and more than 3 cups). Phenolic acids were determined using the Phenol Explorer program. The intake of polyphenols was calculated by adding the values obtained from the total amount of coffee consumed during the day. The Multiple Source Method (MSM) was applied to analyze the usual intake. Results: of the 532 women, 178 (33.5 %) had altered mammographic findings. The participants' average daily coffee intake was 193.4 mL. No significant association was found between coffee consumption and mammographic findings. However, it was found that the second tertile of polyphenols was a protective factor for breast changes. Conclusion: coffee polyphenols are protective against breast changes in the group evaluated and, thus, can help prevent breast cancer.

Resumen Objetivo: este estudio tuvo como objetivo evaluar si existe una asociación de la ingesta de café y sus polifenoles con los hallazgos mamográficos de mujeres tratadas en una unidad de patología mamaria del Sistema Unificado de Salud (SUS), Brasil. Métodos y procedimientos de investigación: este fue un estudio transversal con 532 mujeres tratadas en un servicio de salud. Las participantes se dividieron de acuerdo con sus informes mamográficos en dos grupos: sin y con hallazgos alterados. Se aplicaron dos registros dietéticos de 24 horas y el consumo de café se clasificó en tres grupos (menos de 1 taza, 1 a 3 tazas y más de 3 tazas). Los ácidos fenólicos se determinaron utilizando el programa Phenol Explorer. La ingesta de polifenoles se calculó sumando los valores obtenidos de la cantidad total de café consumido durante el día. Se aplicó el método de fuentes múltiples (MSM) para analizar la ingesta habitual. Resultados: de las 532 mujeres, 178 (33,5 %) tenían hallazgos mamográficos alterados. La ingesta diaria promedio de café de los participantes fue de 193,4 ml. No se encontró una asociación significativa entre el consumo de café y los hallazgos mamográficos. Sin embargo, se encontró que el segundo tercil de polifenoles era un factor protector para los cambios mamarios. Conclusión: los polifenoles del café son protectores contra los cambios mamarios en el grupo evaluado y, por lo tanto, podrían ayudar a prevenir el cáncer de mama.

https://doi.org/10.20960/nh.04060

Randomized clinical trial to evaluate the effect on postprandial glycemia of Nutren Control®, a glycemia-targeted specialized supplement, compared to standardized breakfast in patients with type-2 diabetes: the CONTROL DIABETES study
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Zagury, Roberto Luis

; Sampaio-Lacativa, Paulo Gustavo

; de Gregório, Luiz Henrique

; Abrahão-Schilling-Rosenfeld, Valéria

; Fuganti-Campos, Leticia

; Calixto-Pinheiro, Renata Alexandra

; Ferreira-da Costa, Samuel

; Tavares-Russo, Luís Augusto

Nutrición Hospitalaria

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feb 2023, Volume 40 N. 1 Pages 41 - 48

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Objetivo: evaluar los efectos de un suplemento especializado en el control de la glucosa (GTSS) frente a un desayuno estándar sobre la glucemia posprandial (PPG). Metodología: es un estudio cruzado, prospectivo, aleatorizado en el que se incluyeron a pacientes con diabetes tipo 2 (T2D) con control subóptimo de la glucemia (HbA1c entre 6,5 y 8,5 %) utilizando monoterapia con metformina. El desayuno estandarizado fue isocalórico en comparación con el GTSS y solamente la distribución calórica fue diferente. Ambas intervenciones se utilizaron una vez al día por la mañana, reemplazando cada una el desayuno durante 7 días consecutivos (14 días de observación). Se utilizó el sistema de monitoreo continuo de glucosa (isCGM) para determinar las diferencias entre las intervenciones con respecto al área bajo la curva (iAUC) de glucosa postprandial (PPG) (3 horas después de la intervención) como variable principal o primaria; las variables secundarias fueron la diferencia entre las intervenciones con respecto al pico glicémico, la excursión de glucosa posprandial (PPGE), la glucosa media en sangre (MBG) y el rango de tiempo (TIR). Resultado: se incluyeron treinta y un pacientes con T2D con edades entre 39 y 69 años. El grupo del GTSS tuvo un área bajo la curva (iAUC) significativamente más baja de la PPG en comparación con el grupo del desayuno estandarizado (33,3 [15,0 a 54,0] frente a 46,8 [27,3 a 75,1] mg/dL), mientras que también presentó una PPG significativamente más baja (26,4 + 17,2 vs. 44,8 + 24,4 mg/dL). No hubo diferencia entre los períodos de intervención con respecto a la MBG, el TIR y eventos hipoglucémicos. Conclusión: el nuevo GTSS, como sustituto del desayuno, produjo una reducción de la iAUC de la PPG del 25 %, según el isCGM, en comparación con un desayuno isocalórico normalizado.

Abstract Objective: to evaluate the effects of a new glycemia targeted specialized supplement (GTSS) compared to a standard breakfast on postprandial blood glucose (PPG). Methods: patients with type 2 diabetes (T2D) and suboptimal control (A1C between 6.5 and 8.5 %) in monotherapy with metformin were included to this prospective, randomized, crossover trial. The standardized breakfast was isoenergetic compared to the GTSS, differing on macronutrients distribution. Both interventions were used once a day in the morning, each replacing breakfast for 7 consecutive days (14 days of observation). Intermittent scanning continuous glucose monitoring system (isCGM) determined the difference between the interventions regarding the incremental area under the curve (iAUC) of the PPG (3 hours after intervention), as a primary endpoint; secondary endpoints were the difference between the interventions regarding the glycemic peak, postprandial glucose excursion (PPGE), mean blood glucose (MBG) and time in range (TIR). Results: thirty-one T2D patients with ages between 39 and 69 years-old were enrolled. GTSS group had significantly lower iAUC of the PPG compared to standardized breakfast (33.3 [15.0 to 54.0] vs 46.8 [27.3 to 75.1] mg/dL), while also presenting a significantly lower PPG excursion (26.4 ± 17.2 vs 44.8 ± 24.4 mg/dL). There was no difference between the intervention periods regarding MBG, TIR and hypoglycemic events. Conclusion: the new GTSS, as a meal replacement in the breakfast, produced a 25 % reduction in the iAUC of the PPG, as accessed by isCGM, in comparison with an isocaloric-standardized meal.

https://doi.org/10.20960/nh.04204

BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR SYSTEMIC TREATMENT OF HEPATOCELLULAR CARCINOMA
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CHAGAS, Aline Lopes

; LEAL, Cassia Regina Guedes

; MELLO, Vivianne Barreto de

; BARROS, Fábio Marinho Do Rego

; BITTENCOURT, Paulo Lisboa

; MATTOS, Angelo A

; AROUCHA, Dayse

; FONSECA, Leonardo G da

; SILVA, Joyce Roma Lucas de

; DOTTORI, Mariana Fonseca

; TEIXEIRA, Rosangela

; MENDES, Liliana Sampaio Costa

; REZENDE, Rosamar Eulira Fontes

; FILGUEIRA, Norma Arteiro

; COUTINHO, Anelisa K

; ARAÚJO NETO, João Marcello de

; COELHO, Henrique Sergio Moraes

; PESSOA, Mario Guimarães

; CHEINQUER, Hugo

; PARISE, Edison Roberto

; FRANÇA, Alex

; ÁLVARES-DA-SILVA, Mário Reis

; CARRILHO, Flair José

; CORAL, Gabriela P

; PINTO, Paulo de Tarso Aparecida

; PEREIRA, Leila M M Beltrão

; PARANÁ, Raymundo

; ALVES, Rogério Camargo Pinheiro

; BRANDÃO-MELLO, Carlos Eduardo

Arquivos de Gastroenterologia

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jan 2023, Volume 60 N. 1 Pages 106 - 131

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2020 the updated recommendations for the diagnosis and treatment of HCC. Since then, new data have emerged in the literature, including new drugs approved for the systemic treatment of HCC that were not available at the time. The SBH board conducted an online single-topic meeting to discuss and review the recommendations on the systemic treatment of HCC. The invited experts were asked to conduct a systematic review of the literature on each topic related to systemic treatment and to present the summary data and recommendations during the meeting. All panelists gathered together for discussion of the topics and elaboration of the updated recommendations. The present document is the final version of the reviewed manuscript containing the recommendations of SBH and its aim is to assist healthcare professionals, policy-makers, and planners in Brazil and Latin America with systemic treatment decision-making of patients with HCC.

RESUMO O carcinoma hepatocelular (CHC) é uma das principais causas de mortalidade relacionada a câncer no Brasil e no mundo. A Sociedade Brasileira de Hepatologia (SBH) publicou em 2020 a atualização das recomendações da SBH para o diagnóstico e tratamento do CHC. Desde então, novas evidências científicas sobre o tratamento sistêmico do CHC foram relatadas na literatura médica, incluindo novos medicamentos aprovados que não estavam disponíveis na época do último consenso, levando a diretoria da SBH a promover uma reunião monotemática on-line para discutir e rever as recomendações sobre o tratamento sistêmico do CHC. Um grupo de experts foi convidado para realizar uma revisão sistemática da literatura e apresentar uma atualização, baseada em evidências científicas, sobre cada tópico relacionado ao tratamento sistêmico e a apresentar os dados e recomendações resumidas durante a reunião. Todos os painelistas se reuniram para discutir os tópicos e elaborar as recomendações atualizadas. O presente documento é a versão final do manuscrito revisado, contendo as recomendações da SBH, e seu objetivo é auxiliar os profissionais de saúde, formuladores de políticas e planejadores no Brasil e na América Latina na tomada de decisões sobre o tratamento sistêmico de pacientes com CHC.

https://doi.org/10.1590/s0004-2803.202301000-14

Medicalização do sofrimento psíquico na Atenção Primária à Saúde em um município do interior do Ceará
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Santos, Jomábia Cristina Gonçalves dos

; Cavalcante, Dimas Sampaio

; Vieira, Camilla Araújo Lopes

; Quinderé, Paulo Henrique Dias

Physis: Revista de Saúde Coletiva

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2023, Volume 33 elocation e33010

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este trabalho objetiva discutir como o fenômeno da medicalização do sofrimento psíquico se apresenta no discurso e na prática dos profissionais da Atenção Primária à Saúde. Foram realizadas observações sistemáticas e entrevistas semidiretivas com sete trabalhadores do município de Iguatu, Ceará, Brasil. A análise dos dados foi feita através da Análise de Conteúdo, de Bardin. Os resultados apontaram para uma centralidade no uso de medicação para atender o sofrimento psíquico que chega às unidades de saúde. Os profissionais discorreram sobre o medicamento enquanto uma estratégia rápida e eficiente, que, em consonância com a literatura pesquisada, pode ser utilizada como um dispositivo de controle do sujeito em adoecimento psíquico. Considera-se possível mobilizar, junto aos profissionais, espaços de discussão que apontem para o cuidado da pessoa com sofrimento psíquico através do uso de tecnologias leves, como escuta, vínculo e diálogo.

Abstract This paper aims to discuss how the phenomenon of the medicalization of psychological distress appears in the discourse and practice of Primary Health Care professionals. Systematic observations and semi-directive interviews were conducted with seven workers in the city of Iguatu, Ceará, Brazil. Data analysis was performed using Bardin's Content Analysis. The results pointed to a centrality in the use of medication to attend the psychological suffering that reaches the health units. The professionals spoke about the medication as a quick and efficient strategy, which, in line with the researched literature, can be used as a device to control the subject in psychic illness. It is considered possible to mobilize discussion spaces with professionals that point to the care of people with psychological distress through the use of light technologies, such as listening, bonding and dialogue.Resumo: Este trabalho objetiva discutir como o fenômeno da medicalização do sofrimento psíquico se apresenta no discurso e na prática dos profissionais da Atenção Primária à Saúde. Foram realizadas observações sistemáticas e entrevistas semidiretivas com sete trabalhadores do município de Iguatu, Ceará, Brasil. A análise dos dados foi feita através da Análise de Conteúdo, de Bardin. Os resultados apontaram para uma centralidade no uso de medicação para atender o sofrimento psíquico que chega às unidades de saúde. Os profissionais discorreram sobre o medicamento enquanto uma estratégia rápida e eficiente, que, em consonância com a literatura pesquisada, pode ser utilizada como um dispositivo de controle do sujeito em adoecimento psíquico. Considera-se possível mobilizar, junto aos profissionais, espaços de discussão que apontem para o cuidado da pessoa com sofrimento psíquico através do uso de tecnologias leves, como escuta, vínculo e diálogo.

https://doi.org/10.1590/s0103-7331202333010

Medicalização do sofrimento psíquico na Atenção Primária à Saúde em um município do interior do Ceará
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Santos, Jomábia Cristina Gonçalves dos

; Cavalcante, Dimas Sampaio

; Vieira, Camilla Araújo Lopes

; Quinderé, Paulo Henrique Dias

Physis: Revista de Saúde Coletiva

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2023, Volume 33 elocation e33010

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0103-7331202333010

A Teoria Crítica da Tecnologia de Andrew Feenberg: reflexões sobre a inserção de novos elementos tecnológicos no ambiente escolar
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Sampaio Junior, Luiz Henrique

Revista Brasileira de Estudos Pedagógicos

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dec 2022, Volume 103 N. 265 Pages 786 - 807

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract: The study discusses the insertion of technological elements in the school environment from the perspective Andrew Feenberg’s Critical Theory of Technology. It was carried a literature review and an analysis of six thesis defended between 2015 and 2018 at universities of the State of São Paulo. Through a qualitative analysis, it was adopted as investigative criteria his critical-philosophical contribution considering two main aspects: the treatment in face of the ambivalence between the uses of technical designs and its effects; the understanding about teaching automation. Epistemological criticism of technology seldom appears on research. Conversely, understanding that this is a necessary and urgent insertion shows in the majority of works; the majority of thesis revealed enthusiastic about the idea of automation; the discussion between ‘informational content’ and ‘processes’ of creation and production rarely appears; and most works defend that new technologies are conducive to a more democratic environment. It was revealed, overall, that the idea of using technical instruments at school is rarely reproached. It is also revealed that the sample space should not suit a wide generalization, but a critical cutout of Sao Paulo State universities’ production on the observed years.

Resumen: El estudio discute la inserción de elementos tecnológicos en el ambiente escolar desde la Teoría Crítica de la Tecnología de Andrew Feenberg. Se realizó una revisión de literatura y el análisis de seis tesis defendidas en universidades del estado de São Paulo entre 2015 y 2018. Por medio de un análisis cualitativo, fueron adoptados como criterios investigativos su aporte crítico-filosófico delante de dos aspectos principales: tracto debido a la ambivalencia entre los usos que son hechos de los designs técnicos y sus efectos; comprensión acerca de la automación de la enseñanza. La crítica epistemológica de la tecnología poco aparece en las pesquisas. Todavía, el entendimiento de que esa inserción es necesaria y urgente hace parte del escopo de la mayoría de los trabajos; la mayoría de las tesis ha evidenciado entusiasmo con relación a la idea de automación; la discusión entre ‘contenido informativo’ y ‘procesos’ de creación y producción raramente es abordada; la mayor parte de los trabajos defiende que las nuevas tecnologías permiten un ambiente más democrático. Se comprende, en general, poca criticidad con relación a la idea del uso de instrumentos técnicos en la escuela. Se entiende que la muestra utilizada no debe servir a una ampla generalización, pero a un recorte crítico de lo que se ha producido en las universidades del estado de São Paulo entre los años analizados.

Resumo: O estudo discute a inserção de elementos tecnológicos no ambiente escolar a partir da Teoria Crítica da Tecnologia, de Andrew Feenberg. Realizou-se uma revisão de literatura e a análise de seis teses defendidas em universidades estaduais paulistas entre 2015 e 2018. Por meio de uma análise qualitativa, foram adotados como critérios investigativos seu aporte crítico-filosófico diante de dois aspectos principais: trato em face da ambivalência entre os usos que são feitos dos designs técnicos e os seus efeitos; e compreensão sobre a automação do ensino. A crítica epistemológica da tecnologia pouco aparece nas pesquisas. Em contrapartida, o entendimento de que essa inserção é necessária e urgente faz parte do escopo da maioria dos trabalhos; a maior parcela das teses se mostrou entusiasta com relação à ideia de automação; a discussão entre “conteúdo informacional” e “processos” de criação e produção é raramente abordada; e a maior parte dos trabalhos defende que as novas tecnologias permitem um ambiente mais democrático. Compreende-se, num âmbito geral, pouca criticidade com relação à ideia do uso de instrumentos técnicos na escola. Entende-se que o universo amostral utilizado não deve servir a uma ampla generalização, porém a um recorte crítico do que se produziu nas universidades estaduais paulistas entre os anos analisados.

https://doi.org/10.24109/2176-6681.rbep.103i265.5198

Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: part II
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Santos, Paulo Sergio Faro

; Melhado, Eliana Meire

; Kaup, Alexandre Ottoni

; Costa, Aline Turbino Neves Martins da

; Roesler, Célia Aparecida de Paula

; Piovesan, Élcio Juliato

; Sarmento, Elder Machado

; Theotonio, Giselle Oliveira Martins

; Campos, Henrique Carneiro de

; Fortini, Ida

; Souza, Jano Alves de

; Maciel Júnior, Jayme Antunes

; Segundo, João Batista Alves

; Carvalho, João José Freitas de

; Speziali, José Geraldo

; Calia, Leandro Cortoni

; Barea, Liselotte Menke

; Queiroz, Luiz Paulo

; Souza, Marcio Nattan Portes

; Figueiredo, Marcos Ravi Cerqueira Ferreira

; Costa, Maria Eduarda Nobre de Magalhães

; Peres, Mário Fernando Prieto

; Jurno, Mauro Eduardo

; Peixoto, Patrícia Machado

; Kowacs, Pedro André

; Rocha Filho, Pedro Augusto Sampaio

; Moreira Filho, Pedro Ferreira

; Silva Neto, Raimundo Pereira

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

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sep 2022, Volume 80 N. 9 Pages 953 - 969

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Migraine affects 1 billion people worldwide and > 30 million Brazilians; besides, it is an underdiagnosed and undertreated disorder. Objective The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience. Methods Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy. Results From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease. Conclusions Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options.

Resumo Antecedentes Migrânea afeta um bilhão de pessoas em todo o mundo e mais de 30 milhões de brasileiros; além disso, é um distúrbio subdiagnosticado e subtratado. Objetivo Sabe-se sobre a necessidade de difundir o conhecimento sobre o tratamento profilático da migrânea; por isso, a Sociedade Brasileira de Cefaleias (SBCe) nomeou um comitê de autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da migrânea episódica com base em artigos da literatura mundial, assim como da experiência pessoal. Métodos As reuniões foram realizadas inteiramente online, com a participação de 12 grupos que revisaram e escreveram sobre as categorias farmacológicas dos medicamentos e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de medicamentos estudadas na parte II deste Consenso foram: anti-hipertensivos, inibidores seletivos de recaptação de serotonina, inibidores de recaptação de serotonina e noradrenalina, bloqueadores dos canais de cálcio, outros medicamentos e politerapia racional. Resultados Desta lista de medicamentos, apenas o candesartan foi estabelecido como eficaz no controle da migrânea episódica. Flunarizina, venlafaxina, duloxetina e pizotifeno foram definidos como provavelmente eficazes, enquanto lisinopril, enalapril, escitalopram, fluvoxamina, quetiapina, atorvastatina, sinvastatina, ciproheptadina e melatonina foram possivelmente eficazes na profilaxia da doença. Conclusões Apesar do esforço da comunidade científica em encontrarmedicamentos realmente eficazes no tratamento da migrânea, dado o grande número de medicamentos testados para este fim, ainda dispomos de poucas opções terapêuticas.

https://doi.org/10.1055/s-0042-1755320

Consensus of the Brazilian Headache Society (SBCe) for the Prophylactic Treatment of Episodic Migraine: part I
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Melhado, Eliana Meire

; Santos, Paulo Sergio Faro

; Kaup, Alexandre Ottoni

; Costa, Aline Turbino Neves Martins da

; Roesler, Célia Aparecida de Paula

; Piovesan, Élcio Juliato

; Sarmento, Elder Machado

; Theotonio, Giselle Oliveira Martins

; Campos, Henrique Carneiro de

; Fortini, Ida

; Souza, Jano Alves de

; Maciel Júnior, Jayme Antunes

; Segundo, João Batista Alves

; Carvalho, João José Freitas de

; Speziali, José Geraldo

; Calia, Leandro Cortoni

; Barea, Liselotte Menke

; Queiroz, Luiz Paulo

; Souza, Marcio Nattan Portes

; Figueiredo, Marcos Ravi Cerqueira Ferreira

; Costa, Maria Eduarda Nobre de Magalhães

; Peres, Mário Fernando Prieto

; Jurno, Mauro Eduardo

; Peixoto, Patrícia Machado

; Kowacs, Pedro André

; Rocha-Filho, Pedro Augusto Sampaio

; Moreira Filho, Pedro Ferreira

; Silva-Neto, Raimundo Pereira

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

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aug 2022, Volume 80 N. 8 Pages 845 - 861

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The Brazilian Headache Society (Sociedade Brasileira de Cefaleia, SBCe, in Portuguese) nominated a Committee of Authors with the aim of establishing a consensus with recommendations regarding prophylactic treatment for episodic migraine based on articles published in the worldwide literature, as well as personal experience. Migraine affects 1 billion people around the world and more than 30 million Brazilians. In addition, it is an underdiagnosed and undertreated disorder. It is well known within the medical community of neurologists, and especially among headache specialists, that there is a need to disseminate knowledge about prophylactic treatment for migraine. For this purpose, together with the need for drug updates and to expand knowledge of the disease itself (frequency, intensity, duration, impact and perhaps the progression of migraine), this Consensus was developed, following a full online methodology, by 12 groups who reviewed and wrote about the pharmacological categories of the drugs used and, at the end of the process, met to read and establish conclusions for this document. The drug classes studied were: anticonvulsants, tricyclic antidepressants, monoclonal anti-calcitonin gene-related peptide (anti-CGRP) antibodies, beta-blockers, antihypertensives, calcium channel inhibitors, other antidepressants (selective serotonin reuptake inhibitors, SSRIs, and dual-action antidepressants), other drugs, and polytherapy. Hormonal treatment and anti-inflammatories and triptans in minimum prophylaxis schemes (miniprophylaxis) will be covered in a specific chapter. The drug classes studied for part I of the Consensus were: anticonvulsants, tricyclic antidepressants, monoclonal anti-CGRP antibodies, and beta-blockers.

Resumo A Sociedade Brasileira de Cefaleia (SBCe) nomeou um Comitê de Autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da enxaqueca episódica com base em artigos da literatura mundial e da experiência pessoal. A enxaqueca é um distúrbio subdiagnosticado e subtratado que acomete um bilhão de pessoas no mundo e mais de 30 milhões de brasileiros. É conhecido na comunidade médica de neurologistas e, sobretudo, dos especialistas em cefaleia, a necessidade de se divulgar o conhecimento sobre o tratamento profilático da enxaqueca. Com esta finalidade, aliada às necessidades de atualizações de drogas e de se aumentar o conhecimento sobre a doença em si (frequência, intensidade, duração, impacto e talvez a progressão da enxaqueca), foi elaborado este Consenso, com metodologia totalmente on-line, por 12 grupos que revisaram e escreveram sobre as categorias farmacológicas das drogas e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de drogas estudadas para este Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais do antipeptídeo relacionado ao gene da calcitonina (peptídeo relacionado ao gene da calcitonina — anti-CGRP), betabloqueadores, anti-hipertensivos, inibidores dos canais de cálcio, outros antidepressivos (inibidores seletivos de recaptação de serotonina, ISRSs, e antidepressivos de ação dual), outras drogas, e politerapia. O tratamento hormonal, bem como anti-inflamatórios e triptanas em esquema de profilaxia mínima (miniprofilaxia), será abordado em um capítulo próprio. As classes de drogas estudadas na parte I do Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais anti-CGRP, e betabloqueadores.

https://doi.org/10.1055/s-0042-1756441

Higher carbohydrate quality index is associated with better adequate micronutrient consumption in Brazilian women
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Teixeira-Cacau, Leandro

; Alves de Carvalho-Sampaio, Helena

; Ferreira-Carioca, António Augusto

; Nogueira-Bezerra, Ilana

; Porto-Pinheiro, Luiz Gonzaga

; Diógenes-Vasques, Paulo Henrique

; Rocha, Daianne Cristina

; Florencio-Meneses, Ayana

; de Rezende Ferreira-Mendes, Ana Luiza

Nutrición Hospitalaria

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jun 2022, Volume 39 N. 3 Pages 594 - 602

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: el consumo inadecuado de micronutrientes es un problema de salud pública emergente que puede comprometer la salud. Objetivos: evaluar si la calidad de los carbohidratos de la dieta está asociada con el consumo de 13 micronutrientes en una muestra de mujeres monitoreadas por el Sistema Único de Salud de Brasil. Métodos: este estudio transversal incluyó a 648 mujeres monitoreadas por el Sistema Único de Salud de Brasil. La asociación entre la calidad de los carbohidratos de la dieta y la adecuación del consumo de 13 micronutrientes se investigó mediante modelos de regresión logística ajustados por posibles variables de confusión. Resultados: el consumo de micronutrientes aumentó a medida que mejoraba la calidad de los carbohidratos. Los micronutrientes con mayor prevalencia de ingesta inadecuada fueron: vitamina A, magnesio, manganeso y tiamina. Después de los ajustes mediante modelos de regresión logística, las mujeres del tercer tercil del índice de calidad de carbohidratos tenían menos probabilidades de tener un consumo inadecuado de magnesio (odds ratio (OR): 0,29; intervalo de confianza (IC) del 95 %: 0,14-0,59), manganeso (OR: 0,32 ; IC del 95 %: 0,21 a 0,49) y cobre (OR: 0,22; IC del 95 %: 0,12 a 0,37). Conclusiones: la ingesta de una mayor calidad de carbohidratos en la dieta se asocia con una mejor adecuación en el consumo de la mayoría de los micronutrientes en mujeres monitoreadas por el Sistema Único de Salud de Brasil, especialmente magnesio, manganeso y cobre, después del ajuste mediante modelos de regresión.

Abstract Introduction: inadequate consumption of micronutrients is an emerging public health problem that can compromise health. Objectives: to assess whether the quality of dietary carbohydrates is associated with the consumption of 13 micronutrients in a sample of women monitored by the Brazilian Unified Health System. Methods: this cross-sectional study included 648 women monitored by the Brazilian Unified Health System. The association between quality of dietary carbohydrates and adequacy of consumption of 13 micronutrients was investigated using logistic regression models adjusted for potential confounding variables. Results: the consumption of micronutrients increased as the quality of carbohydrates improved. The micronutrients with the highest prevalence of inadequate intake were vitamin A, magnesium, manganese, and thiamine. After adjustments using logistic regression models, women in the third tertile of the carbohydrate quality index were less likely to have an inadequate consumption of magnesium (odds ratio (OR), 0.29; 95 % confidence interval (CI), 0.14-0.59), manganese (OR, 0.32; 95% CI, 0.21-0.49), and copper (OR, 0.22; 95% CI, 0.12-0.37). Conclusions: intake of a higher quality of dietary carbohydrates is associated with improved adequacy in consumption of most micronutrients in women monitored by the Brazilian Unified Health System, especially magnesium, manganese, and copper, after adjustment using regression models.

https://doi.org/10.20960/nh.03662

10.

Myrcia (Myrtaceae) in the Vale Natural Reserve, Linhares, Espírito Santo, Brazil
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Scaravelli, Fernanda Savioli

; Gaem, Paulo Henrique

; Valdemarin, Karinne Sampaio

; Lucas, Eve

; Mazine, Fiorella Fernanda

Rodriguésia

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2022, Volume 73 elocation e02352020

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Myrcia (Myrteae, Myrtaceae) é representada por 101 espécies no estado brasileiro do Espírito Santo, contudo, estudos florísticos com este gênero ainda são escassos neste centro de diversidade e endemismo. Neste contexto, um estudo taxonômico de Myrcia na Reserva Natural Vale (RNV), Linhares, Espírito Santo, é aqui apresentado. Quarenta e seis espécies foram registradas neste estudo, compreendendo 46% da riqueza do gênero no Espírito Santo. Vinte e cinco espécies (54%) são endêmicas do domínio atlântico e sete são endêmicas do Espírito Santo. Myrcia scytophylla é registrada na floresta atlântica pela primeira vez e M. cymatophylla, M. congestiflora e M. ferruginosa são novas ocorrências para o estado. A composição de espécie revelada por este estudo difere consideravelmente da publicada por uma listagem anterior. Os representantes de Myrcia podem ser encontrados em todas as principais formações vegetais da RNV e em áreas antrópicas. Este sítio deve ser considerado como prioritário para a conservação de táxons pertencentes a Myrcia devido à presença de uma assembleia rica, incluindo espécies restritas e ameaçadas de extinção.

Abstract Myrcia (Myrteae, Myrtaceae) is represented by 101 species in the Brazilian state of Espírito Santo, but local floristic surveys on this genus still lack in this centre of diversity and endemism. In this context, a taxonomic account of Myrcia in the Vale Natural Reserve (VNR), Linhares, Espírito Santo, is presented. Forty-six species were registered in this study, representing 46% of the richness of the genus in Espírito Santo. Twenty-five species (54%) are endemic to the Atlantic domain and seven are endemic to Espírito Santo. Myrcia scytophylla is reported in the Atlantic forest for the first time and M. cymatophylla, M. congestiflora, and M. ferruginosa are new occurrences in the state. Species composition revealed by this study considerably differs from that of a previous checklist. Representatives of Myrcia can be found in all main vegetation types of the VNR and the anthropic areas. The study site must be considered prioritary for conservation of Myrcia due to the presence of a rich assemblage, which also includes restrict and threatened species.

https://doi.org/10.1590/2175-7860202273024

11.

SARS-CoV-2 and rhinovirus infections: are there differences in clinical presentation, laboratory abnormalities, and outcomes in the pediatric population?
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Pereira, Maria Fernanda Bádue

; Suguita, Priscila

; Litvinov, Nadia

; Farhat, Sylvia Costa Lima

; Paula, Camila Sanson Yoshino de

; Lázari, Carolina dos Santos

; Bedê, Pedro Vale

; Framil, Juliana Valeria de Souza

; Bueno, Catarina

; Branas, Priscila Cristina Abduch Adas

; Guimarães, Irina Monteiro da Costa

; Leite, Marcia Marques

; Navega, Ana Carolina Barsaglini

; Nanbu, Danilo Yamamoto

; Schvartsman, Claudio

; Pinho, João Renato Rebello

; Silva, Clovis Artur Almeida

; Marques, Heloisa Helena de Sousa

; Eisencraft, Adriana Pasmanik

; Rossi Jr, Alfio

; Delgado, Artur Figueiredo

; Leal, Gabriela Nunes

; Gibelli, Maria Augusta Cicaroni

; Palmeira, Patricia

; Sakita, Neusa Keico

; Santos, Emilly Henrique dos

; Rocha, Mussya Cisotto

; Kanunfre, Kelly Aparecida

; Okay, Thelma Suely

; Carneiro-Sampaio, Magda

; Carvalho, Werther Brunow de

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e34

Abstract: En | Text: En | PDF: En

ABSTRACT This study aims to assess COVID-19 and other respiratory viruses in pediatric patients. Between April 17 and September 30, 2020, we collected 1,566 respiratory samples from 1,044 symptomatic patients who were younger than 18 years old to assess SARS-CoV-2 infection. Of these, 919 were analyzed for other respiratory pathogens (ORP). Patients with laboratory-confirmed COVID-19 or ORP were included. We evaluated 76 pediatric COVID-19 infections and 157 other respiratory virus infections. Rhinovirus occurred in 132/157 (84%). COVID-19 patients who were significantly older, had more fevers, headaches and pneumonia than those with ORP. The median white blood cell count was lower in patients with SARS-CoV-2 than in those with ORP (6,470 versus 8,170; p=0.02). COVID-19 patients had significantly worse symptoms than those with ORP.

https://doi.org/10.1590/s1678-9946202264034

12.

Investigation of the parasitoid Ixodiphagus hookeri (Hymenoptera: Encyrtidae) in Amblyomma sculptum (Acari: Ixodidae) ticks in the municipality of Salto, São Paulo, Brazil
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Soares, Luciana Aparecida

; Fiorini, Leonardo Costa

; Duarte, Fernanda Calvo

; Almeida, Isabela Barboza de

; Sampaio, Paulo Henrique Selbmann

; Romano, Deborah Mirela de Melo

; Mendes, Marcia Cristina

Arquivos do Instituto Biológico

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2022, Volume 89 elocation e00112022

Abstract: En | Text: En | PDF: En

ABSTRACT The presence of capybaras (Hydrochoerus hydrochaeris) in urban and periurban areas has caused increased numbers of cases of Brazilian spotted fever. With the aim of investigating the presence of the parasitoid Ixodiphagus hookeri in Amblyomma sculptum ticks in the municipality of Salto, state of São Paulo, samples were collected monthly from 14 sites. Thirty samples were placed in containers for observation of the emergence of microhymenopterans and 88 samples were subjected to molecular testing to identify the presence of I. hookeri DNA. Neither dissections nor observation of emergence indicated any presence of I. hookeri larvae in ticks. Samples subjected to polymerase chain reaction (PCR) amplification of the mCOX I region of I. hookeri did not reveal its presence, although fragments corresponding to mRNA 16S of Amblyomma sculptum ticks were amplified in all samples tested.

https://doi.org/10.1590/1808-1657000112022

13.

Production of organic fertilizer based on sewage sludge cultivated with grass under an aeration system
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Cardoso, Paulo Henrique Silveira

; Gonçalves, Paula Wellen Barbosa

; Alves, Gustavo de Oliveira

; Pegoraro, Rodinei Facco

; Sampaio, Regynaldo Arruda

Revista Ceres

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oct 2021, Volume 68 N. 5 Pages 471 - 483

Abstract: En | Text: En | PDF: En

ABSTRACT The cultivation of grasses in sewage sludge (SS) with aeration has the potential for stabilization of sludge organic matter in the production of organic fertilizer. Thus, the objective of this work was to evaluate the cultivation of Urochloa brizantha and Pennisetum purpureum under aerated system on the chemical and biological attributes of SS to obtain a matured organic fertilizer. The study was conducted in a randomized block design in a 2x2+2 factorial scheme with four replications. Factors consisted of cultivation of P. purpureum or U. brizantha in SS, with or without intermittent aeration. Control treatments were SS without cultivation, with or without aeration. Sewage sludge was collected in layers and the chemical and microbial attributes were evaluated. There was no significant difference between treatments for grass dry matter. The C/N ratio was not matched with organic fertilizer stabilization due to similar losses of C and N (~7%). However, microbial activity was reduced in the presence of plant cultivation demonstrating improvement in the properties of the organic fertilizer produced. Through uni- and multivariate analysis, organic fertilizer produced from SS aerated and cultivated with P. purpureum showed matured organic matter.

https://doi.org/10.1590/0034-737x202168050012 34 downloads

14.

Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit
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Silva, Ana Carolina Bueno e

; Anchieta, Leni Márcia

; Rosado, Viviane

; Ferreira, Janita

; Clemente, Wanessa Trindade

; Coelho, Julia Sampaio

; Mourão, Paulo Henrique Orlandi

; Romanelli, Roberta Maia de Castro

Jornal de Pediatria

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jun 2021, Volume 97 N. 3 Pages 329 - 334

Abstract: En | Text: En | PDF: En

Abstract Objective The use of broad-spectrum antimicrobials, such as third and fourth-generation, are responsible for emergence of multidrug-resistant microorganisms in neonatal units. Furthermore, antimicrobial daily doses are not standardized in neonatology. This study aimed to investigate the association between the use of antimicrobial broad spectrum to bacterial sensitivity profile in a referral unit of neonatal progressive care. Methods This is a cohort study conducted in a referral neonatal progressive care unit from January 2008 to December 2016. The data of all hospitalized neonates was collected daily. The infection criteria used were the standardized national criteria, based on definitions of Center for Diseases Control and Prevention. In this study, the use of antimicrobials was evaluated as antimicrobial-day (ATM-day) and the ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was also calculated. The study was approved by the Institutional Review Board of the Universidade Federal de Minas Gerais (ETIC 312/08 e CAAE 58973616.2.0000.5149). Results From 2008 to 2016, 2751 neonates were hospitalized, corresponding to 60,656 patient-days. The ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was 1,3 in the first period and 4,3 in the second period (p = 0,005). Conclusion It was observed that use of broad-spectrum antimicrobials, especially those with coverage for Gram-negative bacteria, was associated with an increase of multidrug-resistant bacteria.

https://doi.org/10.1016/j.jped.2020.06.001 60 downloads

15.

Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An experimental study in rabbits
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De Freitas, Silvio Henrique

; Müller, Alois Foltran

; Fadel, Thaís Ribeiro

; Bessi, Wellington Henrique

; Dória, Renata Gebara Sampaio

; Yamauchi, Kelly Cristiane Ito

; Strefezzi, Ricardo De Francisco

; Vidane, Atanásio Serafim

; Fortulan, Carlos Alberto

; Ambrósio, Carlos Eduardo

Acta Cirúrgica Brasileira

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2021, Volume 36 N. 7 elocation e360704

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose To analyze and compare the reactions at the interface between the composite, composed of fragmented heterologous mineralized bone matrix (MOMHF) and polymethylmethacrylate (PMMA), and the rabbit’s tibias, through macroscopic evaluation and scanning electron microscopy (SEM) in different periods. Methods In this study, 12 New Zealand adult rabbits were used (E1: n = 3, E2: n = 3, E3: n = 3 and E4: n = 3). They had the right tibial defects filled with composite and were evaluated immediately after surgery and at 30, 60, 90, and 120 days. Results The composites were incorporated and integrated into the recipient beds in 100% of the cases, defined by the MOMHF osseointegration and the PMMA fibrointegration, with no sign of infection, migration, or rejection. Conclusions The behavior of the composites in the recipient beds demonstrates that these biomaterials have the potential to be used in bone defect repairs, offering, thus, better quality of life to the orthopedic patient.

https://doi.org/10.1590/acb360704 129 downloads

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