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ABSTRACT: This study assessed the nitrogen nutrition index, morphogenic characteristics and tiller structure of Alexandergrass (Urochloaplantaginea (LINK) Hitch) pasture submitted to different nitrogen (N) levels (zero, 150 or 300 kg ha-1 of N). The experimental design was entirely randomized with repeated measures arrangement. The experimental animals were Angus heifers under rotational stocking grazing method. The number of animals was variable to keep 30±5 cm post-grazing sward height. Nitrogen nutrition index increased linearly according N levels (Ŷ = 59.8 + 0.1216N; P < 0.0001; r²=0.53). The leaf appearance rate adjusted to a positive linear regression model according the thermal sum (TS) with zero of N (Ŷ0N = 0.0077 + 0.0000087TS; P = 0.0308; r² = 0.72) and 150 kg ha-1 of N (Ŷ150N = 0.0020 + 0.000021 TS; P = 0.0022; r² = 0.92). The use of 300 kg ha-1 of N did not alter the leaf appearance rate (0.0124 leaf degree-days-1). The use of up to 300 kg ha-1 of N increases the Alexandergrass nitrogen content. The leaf appearance rate in Alexandergrass is modified using N while the morphogenic characteristics leaf expansion, stem expansion, phyllochron, leaf lifespan, leaf elongation duration and tiller structure are not altered by N utilization.

RESUMO: Este trabalho teve como objetivo avaliar o índice de nutrição nitrogenada, as características morfogênicas e a estrutura dos perfilhos de papuã (Urochloa plantaginea (LINK) Hitch) submetidos a diferentes níveis de nitrogênio (N) (zero, 150 ou 300 kg ha-1 de N). O delineamento experimental foi inteiramente casualizado com medidas repetidas no tempo. Os animais experimentais foram novilhas Angus em regime de pastejo rotacionado. O número de animais foi variável para manter 30 ± 5 cm de altura do pasto pós-pastejo. O índice de nutrição com nitrogênio aumentou linearmente de acordo com os níveis de N (Ŷ = 59,8 + 0,1216N; P < 0,0001; r² = 0,53). A taxa de aparecimento de folhas ajustou-se ao modelo de regressão linear positiva de acordo com a soma térmica (TS) com zero de N (Ŷ0N = 0,0077 + 0,0000087TS; P = 0,0308; r² = 0,72) e 150 kg ha-1 de N (Ŷ150N = 0,0020 +0,000021 TS; P = 0,0022; r² = 0,92). O uso de 300 kg ha-1 de N não alterou a taxa de aparecimento de folhas (0,0124 folha grau-dia-1). O uso de até 300 kg ha-1 de N aumenta o teor de nitrogênio do papuã. A taxa de aparecimento de folhas em papuã é modificada usando N, enquanto que as características morfogênicas expansão foliar, expansão de colmo, filocrono, duração de vida das folhas, duração da elongação foliar e a estrutura dos perfilhos não são alteradas pela utilização de N.

https://doi.org/10.1590/0103-8478cr20210783

Guidelines from the Brazilian society of surgical oncology regarding indications and technical aspects of neck dissection in papillary, follicular, and medullary thyroid cancers
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Farias, Terence

; Kowalski, Luiz Paulo

; Dias, Fernando

; Barreira, Carlos S. Ritta

; Vartanian, José Guilherme

; Tavares, Marcos Roberto

; Vaisman, Fernanda

; Momesso, Denise

; Oliveira, Alexandre Ferreira

; Pinheiro, Rodrigo Nascimento

; Ribeiro, Heber Salvador de Castro

Archives of Endocrinology and Metabolism

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2023, Volume 67 N. 4 elocation e000607

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The purpose of these guidelines is to provide specific recommendations for the surgical treatment of neck metastases in patients with papillary, follicular, and medullary thyroid carcinomas. Materials and methods: Recommendations were developed based on research of scientific articles (preferentially meta-analyses) and guidelines issued by international medical specialty societies. The American College of Physicians’ Guideline Grading System was used to determine the levels of evidence and grades of recommendations. The following questions were answered: A) Is elective neck dissection indicated in the treatment of papillary, follicular, and medullary thyroid carcinoma? B) When should central, lateral, and modified radical neck dissection be performed? C) Could molecular tests guide the extent of the neck dissection? Results/conclusion: Recommendation 1: Elective central neck dissection is not indicated in patients with cN0 well-differentiated thyroid carcinoma or in those with noninvasive T1 and T2 tumors but may be considered in T3-T4 tumors or in the presence of metastases in the lateral neck compartments. Recommendation 2: Elective central neck dissection is recommended in medullary thyroid carcinoma. Recommendation 3: Selective neck dissection of levels II–V should be indicated to treat neck metastases in papillary thyroid cancer, an approach that decreases the risk of recurrence and mortality. Recommendation 4: Compartmental neck dissection is indicated in the treatment of lymph node recurrence after elective or therapeutic neck dissection; “berry node picking” is not recommended. Recommendation 5: There are currently no recommendations regarding the use of molecular tests in guiding the extent of neck dissection in thyroid cancer.

https://doi.org/10.20945/2359-3997000000607

Four Brazilian Potential Species Almost Unexplored of Connaraceae Family Used Popularly for Diabetes: Chemical Composition and in vitro Activity
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Paim, Luís Fernando N. A.

; Acho, Leonard D. R.

; Santos, Paulo Roberto dos

; Toledo, Cássio Augusto P.

; Minello, Luana

; Paz, Joicelene Regina L. da

; Lima, Emerson

; Salvador, Mirian

; Moura, Sidnei

Journal of the Brazilian Chemical Society

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2023, Volume 34 N. 12 Pages 1773 - 1787

Abstract: En | Text: En | PDF: En

Connaraceae is a plant family usually used in traditional medicine. Recently, we have reported the chemical composition and biological activity of 39 species around the world. This work highlights the application of these species to diabetes control, which has been reported at least to half of this family. In this line, there are several species of the Connaraceae without scientific evidence of traditional use, among these the four species study here. Thus, this work aims the chemical composition prospection of Connarus blanchetii, Connarus regnellii, Connarus suberosus and Rourea glazioui, as well as the identification of possible bioactivity. The leaves of these four species were collected, prepared and submitted to different extractive methods (aqueous decoction and infusion and ethanolic maceration), these being tested in a preliminary phytochemical investigation and subjected to antioxidant assay with 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power. Then, we selected the maceration extract to continue for fractions, with the ethyl acetate and n-butanol presenting the best results with antioxidant and anti-advanced glycation end products (AGEs) activity potential. Finally, the chemical composition was determinate by high-resolution mass spectrometry (HRMS) in combination with Global Natural Products Service (GNPS) data bank. As a result, this study indicated the presence of 29 phenolics compounds with reported activity as antioxidant and with potential of protein glycation, supported the diabetes activity of this plants. The n-butanolic fraction of R. glazioui showed compounds such as apigenin, kaempferol, quercetin, myricetin and chlorogenic acid, which have generated a half maximal inhibitory concentration (IC50) of 36.5 µg mL 1 for oxidative glycation inhibition, being highlighted as the most active.

https://doi.org/10.21577/0103-5053.20230070

Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
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Bocchi, Edimar Alcides

; Moreira, Henrique Turin

; Nakamuta, Juliana Sanajotti

; Simões, Marcus Vinicius

; Casas, Alberto de Almeida Las

; Costa, Altamiro Reis da

; Assis, Amberson Vieira de

; Durães, André Rodrigues

; Pereira-Barretto, Antonio Carlos

; Ravessa, Antonio Delduque de Araujo

; Macedo, Ariane Vieira Scarlatelli

; Biselli, Bruno

; Pinto, Carolina Maria Nogueira

; Filho, Conrado Roberto Hoffmann

; Costantini, Costantino Roberto

; Almeida, Dirceu Rodrigues

; Santos Jr, Edval Gomes dos

; Soliva Junior, Erwin

; Figueiredo, Estevão Lanna

; Albuquerque, Felipe Neves de

; Paulitsch, Felipe

; Neuenschwander, Fernando Carvalho

; Figueiredo Neto, José Albuquerque de

; Brito, Flavio de Souza

; Lopes, Heno Ferreira

; Villacorta, Humberto

; Souza Neto, João David de

; Sepulveda, João Mariano

; Ayoub, José Carlos Aidar

; Vilela-Martin, José F.

; Cardoso, Juliano Novaes

; Uemura, Laercio

; Moura, Lidia Zytynski

; Maia, Lilia Nigro

; Oliveira, Lucia Brandão de

; Maia, Lucimir

; Silva, Luís Beck da

; Gowdak, Luís Henrique Wolff

; Danzmann, Luiz Claudio

; Andrade, Marcus

; Braile-Sternieri, Maria Christiane Valeria Braga

; Moreira, Maria da Consolação Vieira

; França Neto, Olimpio R

; Filho, Otavio Rizzi Coelho

; Esteves, Paulo Frederico

; Raupp-da-Rosa, Priscila

; Silva, Ricardo Jorge de Queiroz e

; Mourilhe-Rocha, Ricardo

; Viégas, Ruy Felipe Melo

; Rassi, Salvador

; Mangili, Sandrigo

; Kaiser, Sergio Emanuel

; Martins, Silvia Marinho

; Kawabata, Vitor Sergio

Clinics

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2021, Volume 76 elocation e1991

Abstract: En | Text: En | PDF: En

OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.

https://doi.org/10.6061/clinics/2021/e1991 870 downloads

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease
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Pereira, Andréa Z

; Vigorito, Afonso Celso

; Almeida, Alessandro de Moura

; Candolo, Alexandre de Almeida

; Silva, Ana Carolina Leão

; Brandão-Anjos, Ana Elisa de Paula

; Sá, Bianca Laselva de

; Souza, Catarina Lôbo Santos de

; Castro Junior, Cláudio Galvão de

; Oliveira, José Salvador Rodrigues de

; Barban, Juliana Bernardo

; Mancilha, Elaine Maria Borges

; Todaro, Juliana

; Lopes, Lilian Pinheiro

; Macedo, Maria Cristina Martins de Almeida

; Rodrigues, Morgani

; Ribeiro, Paulo Cesar

; Silva, Roberto Luiz da

; Roberto, Telma Sigolo

; Rodrigues, Thays de Cássia Ruiz

; Colturato, Vergilio Antonio Rensi

; Paton, Eduardo José de Alencar

; Barros, George Maurício Navarro

; Almeida, Rosana Ducatti Souza

; Moreira, Maria Claudia Rodrigues

; Flowers, Mary Evelyn

einstein (São Paulo)

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2020, Volume 18 elocation eAE4799

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O Consenso Brasileiro de Nutrição no Transplante de Células Tronco Hematopoiéticas: doença do enxerto contra o hospedeiro foi aprovado pela Sociedade Brasileira de Transplante de Medula Óssea, com a participação de 26 centros brasileiros de transplante de células-tronco hematopoiéticas. O Consenso descreve as principais condutas nutricionais em casos de doença do enxerto contra o hospedeiro, a principal complicação do transplante de células-tronco hematopoiéticas.

ABSTRACT The Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease was approved by Sociedade Brasileira de Transplante de Medula Óssea , with the participation of 26 Brazilian hematopoietic stem cell transplantation centers. It describes the main nutritional protocols in cases of Graft- versus -host disease, the main complication of hematopoietic stem cell transplantation.

https://doi.org/10.31744/einstein_journal/2020ae4799 1552 downloads

Effect of herbage allowances on biomass flows in Italian ryegrass
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Graminho, Larissa Arnhold

; Rocha, Marta Gomes da

; Pötter, Luciana

; Rosa, Aline Tatiane Nunes da

; Salvador, Paulo Roberto

; Amaral, Luiz Gonzaga do

; Bergoli, Tuani Lopes

; Cadó, Lucas Munareto

Ciência Rural

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2019, Volume 49 N. 7 elocation e20180791

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este trabalho foi conduzido com o objetivo de determinar os fluxos de tecidos foliares em diferentes estádios fenológicos do azevém (Lolium multiflorum Lam.), pastejado por cordeiras, manejado sob três níveis de oferta de forragem (6; 9 e 12 kg de MS/100 kg de peso corporal), sob lotação intermitente. O delineamento experimental foi inteiramente casualizado, com medidas repetidas no tempo. Os fluxos de crescimento e consumo de lâminas foliares, as eficiências real e potencial de utilização do pasto foram similares nas ofertas de forragem e diferentes nos estádios fenológicos do azevém. O consumo de lâminas foliares em porcentagem do peso corporal foi superior na oferta de forragem 12%. Considerando os fluxos de tecidos foliares, o azevém pode ser manejado com ofertas de forragem que variam entre 6 a 12 kg de MS/100 kg de peso corporal.

ABSTRACT: The objective of this study was to determine the leaf tissue flows in Italian ryegrass (Lolium multiflorum Lam.), in different phenological stages, grazed by lambs, and managed under three herbage allowances (6, 9 and 12 kg DM/100 kg body weight under rotational stocking method. The experimental design was completely randomized, with repeated measures arrangement. Forage allowances determined similar growth and intake flows, actual and potential utilization efficiencies of grass and they were different in the phenological stages of Italian ryegrass. The intake of leaf blade, as a percentage of body weight, was higher in the 12% herbage allowance. Considering leaf tissue flows, Italian ryegrass can be managed in forage allowances that vary between 6 and 12 kg DM/100 kg body weight.

https://doi.org/10.1590/0103-8478cr20180791 552 downloads

Fluid escape structures as possible indicators of past gas hydrate dissociation during the deposition of the Barremian sediments in the Recôncavo Basin, NE, Brazil
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Freire, Antonio Fernando Menezes

; Leite, Carlson de Matos Maia

; Oliveira, Flávio Miranda de

; Guimarães, Márcio Ferreira

; Milhomem, Paulo da Silva

; Pietzsch, Raphael

; d’Ávila, Roberto Salvador Francisco

Brazilian Journal of Geology

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jan 2017, Volume 47 N. 1 Pages 79 - 93

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Vesículas elípticas ocas são observadas em afloramentos de arenitos argilosos muito finos e siltitos lacustrinos do Membro Pitanga da Formação Maracangalha, expostos na Ilha de Maré, sudeste da Bacia do Recôncavo, Estado da Bahia, Brasil. Essas rochas foram depositadas em condições subaquosas e são consideradas depósitos gravitacionais do tipo slurry. Essas feições têm sido tradicionalmente interpretadas como sendo estruturas de escape de água, resultado da ação do diapismo de folhelhos sotopostos da Formação Candeias. Este trabalho propõe que as vesículas foram geradas durante uma intensa dissociação de hidratos de gás em resposta à atividade tectônica existente naquele sistema lacustre. O soerguimento tectônico do fundo do lago teria propiciado a redução da pressão confinante nos poros sedimentares, bem como o aumento de temperatura nas águas de fundo, resultando na instabilidade dos hidratos de gás contidos nas porções rasas dos sedimentos e causando uma violenta liberação de metano - ou gás carbônico (CO2) - e água. Se correta, esta proposta tem um grande impacto na interpretação paleoambiental da Bacia do Recôncavo, uma vez que corroborará com a hipótese corrente de que as rochas do Membro Pitanga teriam sido depositadas em ambientes profundos, suficientes para a formação de hidratos de gás e a consequente dissociação em período de soerguimento. Por outro lado, permite uma interpretação adicional acerca da gênese de estruturas de escape de fluidos em rochas sedimentares, lacustres ou marinhas, servindo como um potencial indicador de paleobatimetria.

ABSTRACT: Empty elliptical vesicles are observed in outcrops of Barremian very fine clayey sandstone to siltstone lacustrine slurry deposits of the Pitanga Member (Maracangalha Formation), exposed in the Maré Island, Southern Recôncavo Basin, Brazil. These sedimentary features have been traditionally interpreted as water escape structures triggered by the diapirism of the underlying shales of the Candeias Formation. This work proposes that vesicles were generated during massive gas hydrate dissociation as a result of tectonic activity in a paleolake system. Tectonic uplift would have triggered both the reduction of the confining pressure as well as an increase in lake bottom temperature, resulting in the instability of gas hydrate and causing intense release of both methane - or carbon dioxide (CO2) - and water. On one hand, this proposal has a strong impact on paleoenvironmental interpretations, giving support to the current hypothesis that rocks related to the Pitanga Member would have been deposited under water columns deep enough for gas hydrate formation and subsequent dissociation. On the other hand, it provides new insights on the genesis of fluid escape structures in sedimentary rocks, both lacustrine and marine, providing a paleobathymetric indicator.

https://doi.org/10.1590/2317-4889201720160090 1857 downloads

Morphogenesis and structure of Tifton 85 cultivated in subtropical climate and fertilized with nitrogen
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Tiecher, Diego Daniel

; Rocha, Marta Gomes da

; Pötter, Luciana

; Salvador, Paulo Roberto

; Bergoli, Tuani Lopes

; Milanesi, Gabriela Descovi

Acta Scientiarum. Animal Sciences

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dec 2016, Volume 38 N. 4 Pages 389 - 393

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO. Objetivou-se estudar a morfogênese e a estrutura do Tifton 85 (Cynodon spp.) cultivado em clima subtropical e adubado com nitrogênio (N). O delineamento experimental foi o inteiramente casualizado com quatro níveis de N (Zero; 75; 150 e 225 kg ha-1) em nove repetições por área. Os animais experimentais foram borregas das raças Suffolk. O método de pastejo foi o contínuo para manter a altura do dossel em 15 cm ± 10%. A taxa de expansão de colmos aumenta 0,000027 cm graus-dia-1 para cada kg de N aplicado (modelo linear). De acordo com o modelo não linear, o maior valor de taxa de expansão (0,0226 cm graus-dia-1) foi observado com 220,1 kg ha-1 de N. A duração de vida das folhas ajustou-se ao modelo de regressão linear, com aumento de 50 graus-dia folha-1 comparando-se às doses de 0 e 225 kg ha-1 de N. Conforme o modelo não linear, o maior valor de duração de vida da folha (407,1 graus-dia) foi atingido com 208,8 kg ha-1 de N. Com a manutenção da altura do dossel em aproximadamente 15 cm de altura, recomenda-se utilizar 200 kg ha-1 de N em Tifton 85 cultivado em clima subtropical.

ABSTRACT. The experiment evaluated the morphogenesis and structure of Tifton 85 (Cynodon spp.) cultivated in subtropical climate and fertilized with nitrogen (N). The experiment was a completely randomized design with four levels of N (Zero; 75; 150 or 225 kg ha-1) in nine replicates per area. The experimental animals were Suffolk female lambs. The grazing method was continuous to maintain the sward height at 15 cm ± 10%. The stem expansion increased by 0.000027 cm degree-days-1 to each kg N applied (linear model). According to nonlinear model, the highest stem expansion (0.0226 cm degree-days-1) was observed with the use 220.1 kg ha-1 N. The leaf lifespan fitted a linear regression model, with increase of 50 degree-days leaf -1, comparing the levels zero and 225 kg ha-1 of N. According to nonlinear regression model, the longest leaf lifespan (407.1 degree-days) was observed with the use 208.8 kg ha-1 N. With the maintenance of sward height at approximately 15 cm, we recommended to use 200 kg ha-1 N in Tifton 85 cultivated in subtropical climate.

https://doi.org/10.4025/actascianimsci.v38i4.32147 668 downloads

Patterns of use of time by heifers with or without supplementation at different phenological stages of winter grasses
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Sichonany, Maria José de Oliveira

; Rocha, Marta Gomes da

; Pötter, Luciana

; Salvador, Paulo Roberto

; Bergoli, Tuani Lopes

; Moterle, Paulo Henrique

Acta Scientiarum. Animal Sciences

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jun 2016, Volume 38 N. 2 Pages 197 - 203

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Foi realizada uma análise conjunta de dados, com o objetivo de caracterizar a taxa de ingestão de forragem e os padrões de uso do tempo por novilhas em pastejo de forrageiras de estação fria. Essas novilhas recebiam ou não suplemento energético nos diferentes estádios fenológicos do pasto (vegetativo, pré-florescimento e florescimento). Os experimentos envolveram 360 novilhas, com idade inicial de oito meses e peso corporal médio de 145 ± 17 kg. O método de pastejo foi o de lotação contínua, com número variável de animais. Novilhas recebendo suplemento consumiram 17,0% a menos de forragem e 22,2% a menos de lâminas foliares que as novilhas exclusivamente em pastejo. A atividade de pastejo foi concentrada no turno da tarde, independente do sistema alimentar e dos estádios fenológicos avaliados, e no turno da noite acontece o evento mais longo de ruminação. A taxa de ingestão de forragem é semelhante, independente do consumo de suplemento e dos estádios fenológicos dos pastos.

ABSTRACT A joint data analysis was performed to characterize forage intake rate and patterns of use of time by grazing heifers in cold season pastures. Heifers received or not energetic supplementation at different phenological stages of grasses (vegetative, pre-flowering and flowering). Experiments involved 360 heifers with initial age of eight months and average body weight of 145 ± 17 kg, on continuous grazing method and variable number of animals. Supplementaed heifers consumed 17.0% less forage and 22.2% less leaf blades than heifers exclusively on pasture. Grazing activity was concentrated in the afternoon shift, regardless of the feeding system and phenological stages evaluated, with the longest event of rumination during the night. Forage intake rate is similar, regardless of supplement intake and phenological stages of grasses.

https://doi.org/10.4025/actascianimsci.v38i2.30218 628 downloads

10.

I BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 2: APPROACH TO RESECTABLE METASTASES
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RIBEIRO, Héber Salvador de Castro

; TORRES, Orlando Jorge Martins

; MARQUES, Márcio Carmona

; HERMAN, Paulo

; KALIL, Antonio Nocchi

; FERNANDES, Eduardo de Souza Martins

; OLIVEIRA, Fábio Ferreira de

; CASTRO, Leonaldson dos Santos

; HANRIOT, Rodrigo

; OLIVEIRA, Suilane Coelho Ribeiro

; BOFF, Marcio Fernando

; COSTA Jr, Wilson Luiz da

; GIL, Roberto de Almeida

; PFIFFER, Tulio Eduardo Flesch

; MAKDISSI, Fabio Ferrari

; ROCHA, Manoel de Souza

; AMARAL, Paulo Cezar Galvão do

; COSTA, Leonardo Atem Gonçalves de Araújo

; ALOIA, Tomas A.

; D'ALBUQUERQUE, Luiz Augusto Carneiro

; COIMBRA, Felipe José Fernandez

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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mar 2016, Volume 29 N. 1 Pages 9 - 13

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Racional: As metástases hepáticas de câncer colorretal são evento frequente e potencialmente fatal na evolução dos pacientes. Objetivo : No segundo módulo desse consenso, foi discutido o manejo de metástases hepáticas ressecáveis. Método : Foi definido o conceito de metástases síncrônicas e metacrônicas, e ambos os cenários foram discutidos separadamente de acordo com as suas peculiaridades prognósticas e terapêuticas. Resultados : Foi dada especial atenção às missing metástases em resposta ao tratamento pré-operatório sistêmico, com ênfase em estratégias para evitar sua recorrência e como gerenciar as lesões desaparecidas. Conclusão : Foram apresentadas e validadas estratégias de ressecção em várias circunstâncias, para serem aplicadas na prática clínica.

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients. Aim : In the second module of this consensus, management of resectable liver metastases was discussed. Method : Concept of synchronous and metachronous metastases was determined, and both scenarius were discussed separately according its prognostic and therapeutic peculiarities. Results : Special attention was given to the missing metastases due to systemic preoperative treatment response, with emphasis in strategies to avoid its reccurrence and how to manage disappeared lesions. Conclusion : Were presented validated ressectional strategies, to be taken into account in clinical practice.

https://doi.org/10.1590/0102-6720201600010003 4172 downloads

11.

Comparative study between two recombinant human NPH insulin formulations for the treatment of type 2 diabetes mellitus
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Rassi, Nelson

; Moraes, Sandra Maria Campos Teixeira de

; Alves, Adriana Ganam

; Cavalheiro, Daniela Cunha

; Moreira, Josianny Mesquita

; Bellório, Karini Bruno

; Abreu, Fernanda Cruvinel de

; Prata, Paulo Roberto Mendonça

; Teixeira, Leonardo de Souza

; Rassi, Salvador

Archives of Endocrinology and Metabolism

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feb 2016, Volume 60 N. 1 Pages 47 - 53

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To compare the effects of the neutral protamine Hagedorn (NPH) recombinant human insulin formulations Gansulin and Humulin N® on the glycemic control of patients with type 2 diabetes mellitus (T2DM). Subjects and methods Prospective, double-blind, randomized, parallel, single-center study of 37 individuals with T2DM treated with NPH insulin formulations. The Tukey-Kramer test for multiple comparisons, the Wilcoxon paired comparison test and the Chi-Square test were used for the statistical analyses. The significance level was set at 5% (p < 0.05). Results The NPH insulin formulations Humulin and Gansulin similarly reduced the HbA1c levels observed at the end of the study compared with the values obtained at the beginning of the study. In the Humulin group, the initial HbA1c value of 7.91% was reduced to 6.56% (p < 0.001), whereas in the Gansulin group, the reduction was from 8.18% to 6.65% (p < 0.001). At the end of the study, there was no significant difference between the levels of glycated hemoglobin (p = 0.2410), fasting plasma glucose (FG; p = 0.9257) and bedtime plasma glucose (BG; p = 0.3906) between the two insulin formulations. There was no nt difference in the number of hypoglycemic events between the two insulin formulations, and no severe hyp episodes were recorded. Conclusion This study demonstrated similar glycemic control by NPH insulin Gansulin compared with human insulin Humulin N® in patients with T2DM.

https://doi.org/10.1590/2359-3997000000140 2932 downloads

12.

FIRST BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 1: PRE-TREATMENT EVALUATION
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COIMBRA, Felipe José Fernandez

; RIBEIRO, Heber Salvador de Castro

; MARQUES, Márcio Carmona

; HERMAN, Paulo

; CHOJNIAK, Rubens

; KALIL, Antonio Nocchi

; WIERMANN, Evanius Garcia

; CAVALLERO, Sandro Roberto de Araújo

; COELHO, Fabricio Ferreira

; FERNANDES, Paulo Henrique de Souza

; SILVESTRINI, Anderson Arantes

; ALMEIDA, Maria Fernanda Arruda

; ARAÚJO, Antônio Luis Eiras de

; PITOMBO, Marcos

; TEIXEIRA, Heberton Medeiros

; WAECHTER, Fábio Luiz

; FERREIRA, Fábio Gonçalves

; DINIZ, Alessandro Landskron

; D'IPPOLITO, Giuseppe

; BEGNAMI, Maria Dirlei F. de Sousa

; PROLLA, Gabriel

; BALZAN, Silvio Márcio Pegoraro

; OLIVEIRA, Thiago Bueno de

; SZULTAN, Luís Arnaldo

; LENDOIRE, Javier

; TORRES, Orlando Jorge Martins

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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dec 2015, Volume 28 N. 4 Pages 222 - 230

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Racional : As metástases hepáticas de câncer colorretal são evento frequente e potencialmente fatal na evolução de pacientes com estas neoplasias. Objetivo : Neste módulo procurou-se contextualizar esta situação clínica, bem como parametrizar dados epidemiológicos e de resultados das diversas modalidades de tratamento estabelecidas. Método : Foi realizada discussão sobre como detectar e estadiar o câncer colorretal metastático, bem como o emprego dos métodos de imagem na avaliação de resposta ao tratamento sistêmico instituído. Resultado : Fundamentou na definição de quais pacientes teriam suas metástases consideradas ressecáveis e de como se poderia ampliar a gama de pacientes submetidos às modalidades de tratamento ditas de intuito curativo. Conclusão : Foram apresentados os fatores prognósticos clínicos, patológicos e moleculares com validação para serem levados em consideração na prática clínica.

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients with these tumors. Aim : In this module, was contextualized the clinical situations and parameterized epidemiological data and results of the various treatment modalities established. Method: Was realized deep discussion on detecting and staging metastatic colorectal cancer, as well as employment of imaging methods in the evaluation of response to instituted systemic therapy. Results : The next step was based on the definition of which patients would have their metastases considered resectable and how to expand the amount of patients elegible for modalities with curative intent. Conclusion : Were presented clinical, pathological and molecular prognostic factors, validated to be taken into account in clinical practice.

https://doi.org/10.1590/s0102-6720201500040002 5011 downloads

13.

Fluxos de tecidos foliares em papuã sob pastejo de bezerras de corte em diferentes frequências de suplementação
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Salvador, Paulo Roberto

; Pötter, Luciana

; Rocha, Marta Gomes da

; Eloy, Lidiane Raquel

; Hampel, Viviane da Silva

; Stivanin, Sheila Cristina Bosco

; Rosa, Aline Tatiane Nunes da

; Sichonany, Maria José de Oliveira

Revista Brasileira de Saúde e Produção Animal

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dec 2014, Volume 15 N. 4 Pages 835 - 845

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Foi avaliado o efeito de diferentes frequências de suplementação sobre o uso da pastagem (fluxo de tecido foliar, intensidade e frequência de desfolhação) em papuã (Urochloa plantaginea (Link) Hitch). As bezerras de corte permaneceram exclusivamente em pastejo ou receberam grão inteiro de aveia durante sete ou cinco dias por semana (de segunda à sexta feira). A quantidade semanal de suplemento foi similar nas duas frequências. O delineamento experimental foi inteiramente casualizado, com medidas repetidas no tempo, três tratamentos e duas repetições de área. Os fluxos de tecidos, a frequência e intensidade de desfolhação são similares quando as bezerras permanecem exclusivamente em pastejo ou recebem grão de aveia em diferentes frequências.

The effects of several supplementation frequencies on forage use (leaf tissue flow, intensity and frequency of defoliation) in Alexandergrass (Urochloa plantaginea (Link) Hitch) were evaluated. The heifers remained exclusively on pasture or received whole oat grain seven days/week or five days/week (Monday to Friday). The weekly amount of supplement was similar for both frequencies. The experimental design was completely randomized following a repeated measure arrangement, with three treatments and two area replications. Leaf tissue flow, frequency and intensity of defoliation are similar when heifers remain exclusively on Alexandergrass pasture or receive oat grain on different frequencies.

747 downloads

14.

Tiller dynamics of ryegrass managed under two stocking rates
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Stivanin, Sheila Cristina Bosco

; Rocha, Marta Gomes da

; Potter, Luciana

; Hampel, Viviane da Silva

; Alves, Marcos Bernardino

; Salvador, Paulo Roberto

Acta Scientiarum. Animal Sciences

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sep 2014, Volume 36 N. 3 Pages 279 - 283

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Foi avaliada a dinâmica de perfilhamento de azevém (Lolium multiflorum Lam), sob duas taxas de lotação: 'baixa' e 'alta'. Essas taxas foram determinadas por bezerras, exclusivamente, em pastejo ou em pastejo e recebendo grão de milho ou de aveia branca como suplemento. O delineamento experimental foi inteiramente casualizado, com medidas repetidas no tempo, com duas taxas de lotação, três e seis repetições de área para a taxa de lotação 'baixa' e 'alta', respectivamente. A taxa de aparecimento (1,0 perfilhos perfilho-1 m-2), sobrevivência de perfilhos (0,8 perfilhos perfilho-1 m-2), o índice de estabilidade da população (1,6) e a ocupação de sítios (0,3) foram similares nas taxas de lotação 'alta' e 'baixa'. A densidade populacional de perfilhos foi similar nas diferentes taxas de lotação. A primeira geração de perfilhos representa 56% dos perfilhos existentes no final do ciclo do azevém. O aumento de 22,5% na taxa de lotação ocasionado pelo uso de suplementos para bezerras em pastejo não altera a dinâmica de perfilhamento do azevém.

This study investigated the tiller dynamics of Italian ryegrass (Lolium multiflorum Lam) under low and high stocking rates. These rates were determined by heifers exclusively on pasture or grazing and supplemented with oats and corn grain. The experimental design was completely randomized with repeated measurements over time, with two stocking rates, three and six replications of area for low and high stocking rates, respectively. The appearance rate (1.0 tillers tiller-1 m-2), survival rate (0.8 tillers tiller-1 m-2), population stability index (1.6) and site occupation (0.3) were similar for high and low stocking rates. The tiller density was similar for different stocking rates. The first generation of tillers was 56% of the tiller population at end of the ryegrass cycle. The increase by 22.5% in the stocking rate derived from the use of supplements for grazing heifers did not alter the tiller dynamics of ryegrass.

https://doi.org/10.4025/actascianimsci.v36i3.22912 1205 downloads

15.

Biomass flows and defoliation patterns of alexandergrass pasture grazed by beef heifers, receiving or not protein salt
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Eloy, Lidiane Raquel

; Rocha, Marta Gomes da

; Pötter, Luciana

; Salvador, Paulo Roberto

; Stivanin, Sheila Cristina Bosco

; Hampel, Viviane da Silva

Acta Scientiarum. Animal Sciences

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jun 2014, Volume 36 N. 2 Pages 123 - 128

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O experimento foi conduzido para avaliar os fluxos de biomassa foliar, intensidade e frequência de desfolhação em papuã (Urochloa plantaginea (Link) Hitch), pastejado por bezerras de corte exclusivamente em pastejo ou em pastejo e recebendo sal proteinado. O delineamento foi inteiramente casualizado, com medidas repetidas no tempo, dois tratamentos e duas repetições de área, com três bezerras testes da raça Angus por piquete. O fluxo de consumo de lâminas foliares é 18% superior quando as bezerras permanecem exclusivamente em pastejo. A intensidade de pastejo (59,8%) é semelhante quando as bezerras recebem sal proteinado ou não. Bezerras que recebem suplemento reduzem em um dia a frequência de desfolhação dos perfilhos. O fornecimento de sal proteinado para bezerras de corte em pastejo em papuã resulta em alterações na relação herbívoro-planta reduzindo o fluxo de consumo e a frequência de desfolhação de lâminas foliares.

The experiment aimed at evaluating leaf biomass flow, intensity and frequency of defoliation of Alexandergrass (Urochloa plantaginea (Link) Hitch) by beef heifers exclusively on pasture or that grazed and received protein salt. A completely randomized experimental design was used with repeated measures over time, two treatments and two area replications, with three Angus test heifers by paddock. Leaf blade intake flow is 18% superior for heifers exclusively on pasture. Grazing intensity (59.8%) is similar when heifers receive protein salt or not. Heifers receiving protein salt reduce by one day the defoliation frequency of tillers. The supply of protein salt for beef heifers grazing Alexandergrass affects the herbivore-plant relationship, decreasing intake flow and leaf blade defoliation frequency.

https://doi.org/10.4025/actascianimsci.v36i2.21815 1229 downloads Cited 3 times in SciELO

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