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Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.

https://doi.org/10.1016/j.clinsp.2023.100223

CUIDADO EM SAÚDE DAS MULHERES GRÁVIDAS PRIVADAS DE LIBERDADE: REVISÃO INTEGRATIVA
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Sales, Ana Carolina

; Nakada, Gabrielle Kimie Pinheiro

; Palombit, Mateus Rodrigo

; Conceição, Vander Monteiro

; Baldan, Sueli Santiago

; Farão, Elaine Miguel Delvivo

; Simoneti, Rafaela Azevedo Abrantes de Oliveira

Revista Baiana de Enfermagem

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2021, Volume 35 elocation e36114

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Objective to analyze national and international publications on prenatal care offered to women deprived of their liberty. Method integrative literature review. Searches were conducted in databases, using descriptors and keywords separated by Boolean operators. Tthe search resulted in 548 studies. After analysis of inclusion and exclusion criteria with analytical reading, 11 primary studies were selected, which were organized in the categories national and international studies. Results adjustments and improvements in health care are needed for these women who, even though they have existing rights, are negligent in the care offered. Conclusion the prenatal experience in prison is full of difficulties and peculiarities depending on the penitentiary, requiring managers and health professionals an attentive look at the needs of women, children and their family members, in an attempt to minimize the impacts of the prison context on the quality of life of the people involved.

Objetivo analizar las publicaciones nacionales e internacionales sobre la atención prenatal ofrecida a las mujeres privadas de libertad. Método revisión integradora de la literatura. Las búsquedas se realizaron en bases de datos, utilizando descriptores y palabras clave separadas por operadores boleanos. La búsqueda dio como resultado 548 estudios. Tras analizar los criterios de inclusión y exclusión con lectura analítica, se seleccionaron 11 estudios primarios, que se organizaron en las categorías de estudios nacionales e internacionales. Resultados se necesitan ajustes y mejoras en el cuidado de la salud de estas mujeres que, a pesar de tener derechos existentes, son negligentes en el cuidado ofrecido. Conclusión la experiencia prenatal en la cárcel está llena de dificultades y peculiaridades según el centro penitenciario, lo que exige que los gestores y los profesionales de la salud examinen detenidamente las necesidades de las mujeres, los niños y sus familias, en un intento por reducir al mínimo los efectos del contexto carcelario en la calidad de vida de las personas implicadas.

Objetivo analisar as publicações nacionais e internacionais acerca da assistência ao pré-natal oferecida às mulheres privadas de liberdade. Método revisão integrativa da literatura. As buscas foram realizadas em bases de dados, usando descritores e palavras-chave separadas por operadores boleanos. A busca resultou em 548 estudos. Após análise dos critérios de inclusão e exclusão com leitura analítica, foram selecionados 11 estudos primários, que foram organizados nas categorias estudos nacionais e internacionais. Resultados são necessárias adequações e melhorias na assistência à saúde dessas mulheres que, mesmo tendo direitos vigentes, sofrem negligência na assistência oferecida. Conclusão a vivência do pré-natal no cárcere está repleta de dificuldades e peculiaridades a depender da penitenciária, exigindo dos gestores e dos profissionais de saúde um olhar atento às necessidades da mulher, da criança e de seus familiares, na tentativa de minimizar os impactos do contexto prisional na qualidade de vida das pessoas envolvidas.

https://doi.org/10.18471/rbe.v35.36114 736 downloads

Efeito da música como recurso terapêutico em grupo de convivência para pessoas idosas
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Medeiros, Joycimara da Silva Sales de

; Oliveira, Luciane Paula Batista Araújo de

; Medeiros, Anna Cecília Queiroz de

; Távora, Rafaela Carolini de Oliveira

; Barros, Wanessa Cristina Tomaz dos Santos

Rev Rene

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2021, Volume 22 elocation e60048

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective to analyze the effect of musical interventions to reduce stress levels in the elderly. Methods quantitative research, of quasi-experimental type, in which the level of stress was assessed before and after interventions with the music therapy method, called receptive experience, in 25 elderly people in a support group. The Perceived Stress Scale was used and descriptive and inferential statistical analysis was performed. Results in the assessment of perceived stress, the average was 33.6 (standard deviation 5.17) points in the pre-test and 31.6 (standard deviation 2.29) points in the post-test (p<0.05). In the assessment dimension, the reduction was identified only in the perceived distress factor. Pre-tests outcomes showed that the higher the monthly income, the lower the perceived stress (p=0.043). Conclusion musical interventions with the participants of this study were able to reduce stress levels, indicating the importance of music as a therapeutic resource in health promotion actions.

RESUMO Objetivo analisar o efeito de intervenções musicais na redução dos níveis de estresse em pessoas idosas. Métodos pesquisa quantitativa, do tipo quase-experimental, em que se avaliou o nível de estresse antes e depois de intervenções com música, com o método musicoterápico, denominado experiência receptiva, em 25 pessoas idosas de um grupo de convivência. Utilizou-se da Escala de Estresse Percebido e realizou-se a análise estatística descritiva e inferencial. Resultados na avaliação do estresse percebido, a média foi de 33,6 (Desvio-padrão 5,17) pontos no pré-teste e 31,6 (Desvio-padrão 2,29) pontos no pós-teste (p<0,05). Na avaliação por dimensão, a redução na pontuação foi identificada apenas no fator perceived distress. Identificou-se, no pré-teste, que quanto maior a renda mensal, menor o estresse percebido (p=0,043). Conclusão intervenções musicais com os participantes deste estudo foram capazes de reduzir os níveis de estresse, indicando a validade da música como recurso terapêutico em ações de promoção à saúde.

https://doi.org/10.15253/2175-6783.20212260048 302 downloads

mHealth na prevenção das Infecções Sexualmente Transmissíveis (IST)
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Sales, Rafaela Oliveira de

; Silva, Raimunda Magalhães da

Ciência & Saúde Coletiva

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nov 2020, Volume 25 N. 11 Pages 4315 - 4325

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi analisar na literatura como os aplicativos foram elaborados e como influenciam na prevenção das Infecções Sexualmente Transmissíveis (IST). Levantou-se nas bases de dados PubMed, Periódicos da CAPES e Bireme utilizando os descritores “sexually transmitted diseases” e “mHealth” combinados pelo conector booleano AND. Considerou-se o período entre 2013 e 2017, artigos disponibilizados “on-line” em português e inglês. Os resultados dos estudos mostraram que para a elaboração do aplicativo a pesquisa formativa prevaleceu como método e o grupo focal como a técnica para a coleta de dados. Essa técnica objetiva a troca de experiencia e oportuniza a discussão de assuntos inerentes às infecções. Considera-se que os aplicativos foram construídos com rigor metodológico com a participação de usuários e com recursos instrucionais que influenciam o manejo da prevenção e o controle das infecções.

Abstract The objective of this study was to analyze in the literature how the applications were developed and how they influence the prevention of Sexually Transmitted Infections (STIs). PubMed, CAPES Periodicals and Bireme databases were searched using the descriptors sexually transmitted diseases and mHealth combined by the Boolean connector AND. The search considered studies published between 2013 to 2017 available online in Portuguese and English. The results of the studies showed formative research was the most used method and focus group was the most used technique for data collection in the development of an application. This technique aims at the exchange of experience and allows discussion about issues inherent to infections. The applications were built with methodological rigor with the participation of users and with instructional resources that influence the management of the prevention and control of infections.

https://doi.org/10.1590/1413-812320202511.11022019 1165 downloads

mHealth na prevenção das Infecções Sexualmente Transmissíveis (IST)
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Sales, Rafaela Oliveira de

; Silva, Raimunda Magalhães da

Ciência & Saúde Coletiva

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2020, Volume 25 N. 11 Pages 4315 - 4325

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320202511.11022019

Development and evaluation of an application for syphilis control
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Sales, Rafaela Oliveira de

; Dilts, Lucas Michael

; Silva, Raimunda Magalhães da

; Brasil, Christina Cesar Praça

; Vasconcelos Filho, José Eurico de

Revista Brasileira de Enfermagem

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oct 2019, Volume 72 N. 5 Pages 1326 - 1332

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: desenvolver e avaliar um aplicativo para o controle da sífilis em gestantes. Método: pesquisa metodológica desenvolvida no período de março a novembro de 2016, em duas fases: levantamento bibliográfico dos anos de 2012 a 2016 nas bases de dados PubMed, CAPES e Scopus e desenvolvimento do aplicativo. Participaram do teste de usabilidade: oito usuários e da avaliação cinco médicas e cinco enfermeiras que atuavam no pré-natal. Resultados: o aplicativo contém vídeo informativo, informações sobre a doença, mapa dos postos de saúde, função de agenda e notificação anônima. A avaliação do objetivo, função e relevância foi considerada adequada com valor superior a 0,80 em todos os itens do Índice de Validação de Conteúdo. Considerações finais: o aplicativo facilita a rotina dos serviços de saúde no contexto de promoção da saúde, na convocação e tratamento de gestantes e seus parceiros.

ABSTRACT Objective: to develop and evaluate an application for syphilis control in pregnant women. Method: methodological research developed between March and November of 2016 in two phases: bibliographic survey of the years 2012 to 2016 in the databases PubMed, CAPES and Scopus and application development. Eight users participated in the usability test and five doctors and five nurses working in prenatal care participated in the evaluation. Results: the application contains informative video, information about the disease, map of health clinics, agenda function and anonymous notification. The evaluation of the objective, function and relevance was considered adequate with value higher than 0.80 in all items of the Content Validity Index. Final considerations: the application makes easier the routine of health services in the context of health promotion, in the convocation and treatment of pregnant women and their partners.

RESUMEN Objetivo: desarrollar y evaluar una aplicación para el control de la sífilis en gestantes. Método: Investigación metodológica desarrollada en el período de marzo a noviembre de 2016, en dos fases: levantamiento bibliográfico de los años 2012 a 2016 en las bases de datos PubMed, CAPES y Scopus y desarrollo de la aplicación. Participaron de la prueba de usabilidad ocho usuarios y de la evaluación cinco médicos y cinco enfermeras que actuaban en el prenatal. Resultados: la aplicación contiene vídeo informativo, información sobre la enfermedad, mapa de los puestos de salud, función de agenda y notificación anónima. La evaluación del objetivo, función y relevancia se consideró adecuada con un valor superior a 0,80 en todos los ítems del Índice de Validación de Contenido. Consideraciones finales: la aplicación facilita la rutina de los servicios de salud en el contexto de promoción de la salud, en la convocatoria y tratamiento de gestantes y sus parejas.

https://doi.org/10.1590/0034-7167-2018-0877 2398 downloads

Development and evaluation of an application for syphilis control
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Sales, Rafaela Oliveira de

; Dilts, Lucas Michael

; Silva, Raimunda Magalhães da

; Brasil, Christina Cesar Praça

; Vasconcelos Filho, José Eurico de

Revista Brasileira de Enfermagem

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oct 2019, Volume 72 N. 5 Pages 1326 - 1332

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0034-7167-2018-0877 94 downloads

Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
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Fernandes, Erica de Souza

; Lorena, Virgínia Maria de Barros

; Sales, Iana Rafaela Fernandes

; Albuquerque, Mônica Camelo Pessoa de Azevedo

; Gomes, Yara de Miranda

; Costa, Vlaudia Maria Assis

; Souza, Valdênia Maria Oliveira de

Revista da Sociedade Brasileira de Medicina Tropical

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aug 2018, Volume 51 N. 4 Pages 546 - 549

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.

https://doi.org/10.1590/0037-8682-0338-2016 795 downloads

Água e saúde no município de Igarapé-Açu, Pará
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Sousa, Rafaela Sales de

; Menezes, Luciana Gonçalves Creão de

; Felizzola, Juliana Feitosa

; Figueiredo, Ricardo de Oliveira

; Sá, Tatiana Deane de Abreu

; Guerra, Gutemberg Armando Diniz

Saúde e Sociedade

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dec 2016, Volume 25 N. 4 Pages 1095 - 1107

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este artigo visa analisar e compreender a relação entre água e saúde em comunidades rurais situadas na microbacia do igarapé Cumaru, município de Igarapé-Açu (PA), nordeste paraense. São avaliados a captação e o tratamento de água para o consumo humano, considerando as práticas de esgoto sanitário realizadas cotidianamente pela população rural dessa microbacia, visto que têm implicação direta na saúde da população local. Este trabalho baseia-se em pesquisa de campo com uma abordagem quali-quantitativa. Utilizou-se questionário fechado para o levantamento das fontes de captação, saneamento rural e usos de insumos agrícolas. Foram consideradas observações feitas por agricultores familiares da região ao focar o funcionamento do estabelecimento agrícola, a fim de observar de diversos ângulos a relação entre água e saúde no seu entendimento. Observou-se que a vulnerabilidade das fontes de água acessadas pela população é um fator que contribui para a contaminação das fontes, caracterizando consequentemente uma ameaça à saúde da população rural. Entretanto, nota-se a percepção da população quanto às fontes de água mais profundas, como poços tubulares, sendo estes prioritários para captação de água para ingestão.

Abstract This article aims to analyze and understand the relationship between water and health in rural communities located in the watershed of Cumaru stream, in the municipality Igarapé-Açu, Northeast of Pará state. The harvesting and treatment of the water conducted by the rural population for human consumption were assessed, considering their practices of sanitary sewer, since these aspects have direct impact on their health. This study is based on field research with a quantitative approach. Closed questionnaire was used to raise the sources of water harvesting, rural sanitation, and use of agricultural inputs. We used participant observation, when focusing on the functioning of the agricultural establishment, to observe from various angles the relationship between water and health. We noted that the vulnerability of the water resources accessed by the population is a factor that contributes to the contamination of the sources, therefore a threat to the health of the rural population. However, the perception of the population is notable regarding deeper water sources, such as tube wells, which are priorities for water harvesting.

https://doi.org/10.1590/s0104-12902016157497 4518 downloads

10.

Água e saúde no município de Igarapé-Açu, Pará
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Sousa, Rafaela Sales de

; Menezes, Luciana Gonçalves Creão de

; Felizzola, Juliana Feitosa

; Figueiredo, Ricardo de Oliveira

; Sá, Tatiana Deane de Abreu

; Guerra, Gutemberg Armando Diniz

Saúde e Sociedade

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dec 2016, Volume 25 N. 4 Pages 1095 - 1107

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0104-12902016157497 274 downloads

11.

Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection
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Santos, Patrícia d‘Emery Alves

; Lorena, Virgínia Maria Barros de

; Fernandes, Érica de Souza

; Sales, Iana Rafaela Fernandes

; Nascimento, Wheverton Ricardo Correia do

; Gomes, Yara de Miranda

; Albuquerque, Mônica Camelo Pessoa de Azevedo

; Costa, Vlaudia Maria Assis

; Souza, Valdênia Maria Oliveira de

Memórias do Instituto Oswaldo Cruz

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feb 2016, Volume 111 N. 2 Pages 83 - 92

Abstract: En | Text: En | PDF: En

Schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into: born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from noninfected mothers (control). When adults, the mice were infected and compared the hepatic granuloma size and cellularity. Some animals were OA + adjuvant immunised. We evaluated hypersensitivity reactions (HR), antibodies levels (IgG1/IgG2a) anti-soluble egg antigen and anti-soluble worm antigen preparation, and anti-OA, cytokine production, and CD4+FoxP3+T-cells by splenocytes. Compared to control group, BIM mice showed a greater quantity of granulomas and collagen deposition, whereas SIM and BSIM presented smaller granulomas. BSIM group exhibited the lowest levels of anti-parasite antibodies. For anti-OA immunity, immediate HR was suppressed in all groups, with greater intensity in SIM mice accompanied of the remarkable level of basal CD4+FoxP3+T-cells. BIM and SIM groups produced less interleukin (IL)-4 and interferon (IFN)-g. In BSIM, there was higher production of IL-10 and IFN-g, but lower levels of IL-4 and CD4+FoxP3+T-cells. Thus, pregnancy in schistosomotic mothers intensified hepatic fibrosis, whereas breastfeeding diminished granulomas in descendants. Separately, pregnancy and breastfeeding could suppress heterologous immunity; however, when combined, the responses could be partially restored in infected descendants.

https://doi.org/10.1590/0074-02760150293 1482 downloads

12.

Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency
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Silva, Maria Teresa Nascimento

; Costa, Vlaudia Assis

; Pereira, Teobaldo Gonzaga Realço

; Sales, Iana Rafaela Fernandes

; Silva, Silvana Ferreira da

; Maciel, Maria Amélia Vieira

; Malagueño, Elizabeth

; Souza, Valdênia Maria Oliveira

Revista da Sociedade Brasileira de Medicina Tropical

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dec 2012, Volume 45 N. 6 Pages 761 - 763

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: Pacientes infectados com Ascaris lumbricoides apresentam menor prevalência de dermatite atópica grave. MÉTODOS: Sangue periférico de crianças infectadas com dermatite atópica foi analisado por citometria de fluxo quanto à frequência de células Th1 e Th2 pela expressão de receptores de quimiocina CXCR3 e CCR4, respectivamente. RESULTADOS: Pacientes sem helmintos com dermatite atópica apresentaram alta frequência de células Th2CCR4+. Pacientes parasitados com dermatite atópica apresentaram menor frequência de células Th1CXCR3+ comparados aos indivíduos apenas infectados. CONCLUSÕES: Ascaridiases altera o tráfego sanguíneo de células Th2 em pacientes com dermatite atópica, enquanto a doença alérgica diminui o tráfego de células Th1 em pacientes parasitados.

INTRODUCTION: Ascaris lumbricoides-infected patients present lower prevalence of severe atopic dermatitis. METHODS: Peripheral blood of infected children with atopic dermatitis was assessed by flow cytometry of the frequency of Th1 and Th2 cells through the expression of CXCR3 and CCR4 chemokine receptors, respectively. RESULTS: Helminth-free patients with atopic dermatitis presented a high frequency of CCR4+Th2 cells. Parasitized patients with atopic dermatitis showed a lower frequency of CXCR3+Th1 cells compared to infected individuals only. CONCLUSIONS: Ascariasis modifies the blood traffic of Th2 cells in atopic dermatitis patients, while the allergic disease down-regulates the traffic of Th1 cells in parasitized patients.

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