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[SciELO Preprints] - Socioeconomic development and colorectal cancer mortality in a federative unit of the Legal Amazon, from 2005 to 2016
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Caló, Romero dos Santos Souza, Rita Adriana Gomes de Alves, Mario Ribeiro Carvalho, Alessandra Emidio de Galvão, Noemi Dreyer

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Publication date: 2022-04-25

Abstract: En Pt

Objective: To analyze the correlation between colorectal cancer (CRC) mortality rates and socioeconomic factors in the five mesoregions (North, Northeast, Southeast, Southwest and Center-South) of the state of Mato Grosso, from 2005 to 2016. Methods: Ecological study, which considered deaths from CRC (C18 to C21) of residents of the state. Mortality rates were standardized by the direct method, using the world standard population. For the analysis of socioeconomic factors, the Firjan Municipal Development Index (IFDM) and its components (Education, Income and employment; Health) were used. Means of mortality rates and socioeconomic factors between the mesoregions were tested using ANOVA, and Pearson's correlation coefficient was used to analyze the correlation between mortality rates due to CRC and these factors. Results: In the period from 2005 to 2016, 1,492 deaths from CRC were registered in the state of Mato Grosso. The mesoregion with the highest average of both the crude rate and the standardized rate of mortality from CRC was the Southwest (3.47 and 3.86 deaths/100 thousand inhab.). There was a significant correlation between mortality rates from the disease with the following indicators: General IFDM for the North, Southeast and Center-South mesoregions; Education for the North and Southeast mesoregions; Income and employment for the North and Center-South mesoregions and Health for the North, Southeast and Center-South mesoregions. Conclusion: There was correlation between the CRC mortality rates and better socioeconomic development in the state.

Objetivo: Analisar a correlação entre as taxas de mortalidade por câncer colorretal (CCR) e os fatores socioeconômicos nas cinco mesorregiões (Norte, Nordeste, Sudeste, Sudoeste e Centro-Sul) do estado de Mato Grosso, de 2005 a 2016. Métodos: Estudo ecológico, que considerou os óbitos por CCR (C18 a C21) de residentes do Estado. As taxas de mortalidade foram padronizadas pelo método direto, utilizando-se a população padrão mundial. Para a análise dos fatores socioeconômicos foi utilizado o Índice Firjan de Desenvolvimento Municipal Geral (IFDM) e seus componentes (Educação; Renda e emprego; Saúde). Foram testadas as médias das taxas de mortalidade e dos fatores socioeconômicos entre as mesorregiões por meio da ANOVA, e empregado o coeficiente de correlação de Pearson para análise da correlação entre as taxas de mortalidade por CCR e esses fatores. Resultados: No período de 2005 a 2016, foram registrados 1.492 óbitos por CCR no estado de Mato Grosso. A mesorregião com a maior média tanto da taxa bruta quanto da taxa padronizada de mortalidade por CCR foi a Sudoeste (3,47 e 3,86 óbitos/100 mil hab.). Houve correlação significante entre as taxas de mortalidade por CCR com os seguintes indicadores: IFDM Geral para as mesorregiões Norte, Sudeste e Centro-Sul; Educação para as mesorregiões Norte e Sudeste; Renda e emprego para as mesorregiões Norte e Centro-Sul e Saúde para as mesorregiões Norte, Sudeste e Centro-Sul. Conclusão: Houve correlação da taxa de mortalidade de CCR com melhor desenvolvimento socioeconômico no estado.

https://doi.org/10.1590/1980-549720220006.supl.1.1

Functionality assessment in patients with rheumatic diseases undergoing treatment in the Public Health System
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Souza, Elisa Neide Barbosa de

; Silva, Michael Ruberson Ribeiro da

; Santos, Jéssica Barreto Ribeiro Dos

; Reis, Edna Afonso

; Alvares-Teodoro, Juliana

; Acurcio, Francisco de Assis

; Almeida, Alessandra Maciel

einstein (São Paulo)

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2022, Volume 20 elocation eAO6453

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To evaluate the therapeutic response (functionality) and its associated factors in patients on biological drugs on the Public Health System for treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Methods An open prospective cohort was carried out from 2011 to 2019, in Belo Horizonte (MG). Functionality was assessed using the Health Assessment Questionnaire Disability-Index at baseline, and after 6 and 12 months of follow-up. Factors associated with poor functionality were identified through logistic regression. Results The median Health Assessment Questionnaire Disability-Index at baseline was 1.5 (interquartile range of 0.8-1.9), with poor functionality observed in patients with rheumatoid arthritis. Improved functionality was seen at 6 months of treatment for the three diseases. The predictors of poor functionality at 6 months for psoriatic arthritis and ankylosing spondylitis were female sex, low education levels, and high disease activity; and for rheumatoid arthritis and psoriatic arthritis were female sex, advanced age, and high disease activity. In 12 months, the three diseases had predictors of worse functionality: female sex, low education, and high disease activity. Conclusion There was a significant improvement in functionality during the follow-up, with better response at 6 months of treatment. Poor functionality was observed in older, female patients, with low education and high disease activity.

https://doi.org/10.31744/einstein_journal/2022ao6453

Socioeconomic development and colorectal cancer mortality in a state of the Brazilian Legal Amazon from 2005 to 2016
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Caló, Romero dos Santos

; Souza, Rita Adriana Gomes de

; Alves, Mario Ribeiro

; Carvalho, Alessandra Emidio de

; Galvão, Noemi Dreyer

Revista Brasileira de Epidemiologia

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2022, Volume 25 Suppl. 1 elocation e220006

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Analisar a correlação entre as taxas de mortalidade por câncer colorretal (CCR) e os fatores socioeconômicos nas cinco mesorregiões (norte, nordeste, sudeste, sudoeste e centro-sul) do estado de Mato Grosso, de 2005 a 2016. Métodos: Estudo ecológico que considerou os óbitos por CCR (C18 a C21) de residentes do estado. As taxas de mortalidade foram padronizadas pelo método direto, utilizando-se a população padrão mundial. Para a análise dos fatores socioeconômicos, foram usados o Índice Firjan de Desenvolvimento Municipal Geral (IFDM) e seus componentes (educação; renda e emprego; saúde). Foram testadas as médias das taxas de mortalidade e dos fatores socioeconômicos entre as mesorregiões por meio da análise de variância (ANOVA), e empregou-se o coeficiente de correlação de Pearson para análise da correlação entre as taxas de mortalidade por CCR e esses fatores. Resultados: No período de 2005 a 2016, foram registrados 1.492 óbitos por CCR no estado de Mato Grosso. A mesorregião com a maior média tanto da taxa bruta quanto da taxa padronizada de mortalidade por CCR foi a sudoeste (3,47 e 3,86 óbitos/100 mil habitantes). Houve correlação significante entre as taxas de mortalidade por CCR com os seguintes indicadores: IFDM geral para as mesorregiões norte, sudeste e centro-sul; educação para as mesorregiões norte e sudeste; renda e emprego para as mesorregiões norte e centro-sul; e saúde para as mesorregiões norte, sudeste e centro-sul. Conclusão: Houve correlação da taxa de mortalidade de CCR com melhor desenvolvimento socioeconômico no estado.

ABSTRACT: Objective: To analyze the correlation between colorectal cancer (CRC) mortality rates and socioeconomic factors in the five mesoregions (North, Northeast, Southeast, Southwest and Center-South) of the state of Mato Grosso, from 2005 to 2016. Methods: Ecological study that considered deaths from CRC (C18 to C21) of residents of the state. Mortality rates were standardized by the direct method, using the world standard population. For the analysis of socioeconomic factors, the Firjan Municipal Development Index (IFDM) and its components (education, income and employment and health) were used. Means of mortality rates and socioeconomic factors between the mesoregions were tested using ANOVA, and Pearson’s correlation coefficient was used to analyze the correlation between mortality rates due to CRC and these factors. Results: In the period from 2005 to 2016, 1,492 deaths from CRC were registered in the state of Mato Grosso. The Southwest mesoregion had the highest average for both the crude rate and standardized CRC mortality rates (3.47 and 3.86 deaths/100,000 inhabitants, respectively). There was a significant correlation between mortality rates from the disease with the following indicators: Overall IFDM for the North, Southeast and Center-South mesoregions; education for the North and Southeast mesoregions; income and employment for the North and Center-South mesoregions; and health for the North, Southeast and Center-South mesoregions. Conclusion: There was a correlation between CRC mortality rates and better socioeconomic development in the state.

https://doi.org/10.1590/1980-549720220006.supl.1

Socioeconomic development and colorectal cancer mortality in a state of the Brazilian Legal Amazon from 2005 to 2016 200 201 20 2
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Caló, Romero dos Santos

; Souza, Rita Adriana Gomes de

; Alves, Mario Ribeiro

; Carvalho, Alessandra Emidio de

; Galvão, Noemi Dreyer

Revista Brasileira de Epidemiologia

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2022, Volume 25 Suppl. 1 elocation e220006

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1980-549720220006.supl.1

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

Giardiasis in urban and rural Amazonas, Brazil is driven by zoonotic and cosmopolitan A and B assemblages
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dos Reis, Lisiane Lappe

; da Silva, Túllio Romão Ribeiro

; Braga, Francisco Carlos de Oliveira

; do Nascimento, Naara Macedo

; de Menezes, Katia Maria Lima

; Nava, Alessandra Ferreira Dales

; Lima, Natália Aparecida de Souza

; Vicente, Ana Carolina Paulo

Memórias do Instituto Oswaldo Cruz

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2021, Volume 116 elocation e210280

Abstract: En | Text: En | PDF: En

BACKGROUND Giardia duodenalis is a protozoan parasite that infects humans and other mammals and causes giardiasis worldwide. Giardia is genotyped into eight assemblages (A-H), with assemblages A and B considered zoonotic. OBJECTIVES The aim of this study was to determine the assemblages of G. duodenalis from individuals living in rural and urban areas of the Amazonas State. METHODS 103 human faecal specimens microscopically positive for the presence of Giardia obtained from four municipalities in Amazonas and four animal faecal specimens were genotyped based on the sequences of two genes, triosephosphate isomerase (TPI) and β-giardin (BG). FINDINGS In humans, assemblage A was the most represented with the identification of sub-assemblages AI, AII and AIII based on BG and sub-assemblages AI and AII based on TPI. Similarly, there is a diversity of sub-assemblage B considering BG (B and BIII) and TPI (B, BIII and BIV). In addition, we characterised homogeneous and heterogeneous genotypes comprising assemblages/sub-assemblages A and B in individuals from urban and rural areas. Here, for the first time, it was genotyped Giardia that infects animals from the Brazilian Amazon region. We identified sub-assemblage AI in one Ateles paniscus and two Felis catus and sub-assemblage BIV in one Lagothrix cana. MAIN CONCLUSIONS Therefore, humans and animals from the urban and rural Amazon share Giardia genotypes belonging to assemblages A and B, which are found in cosmopolitan regions around the world.

https://doi.org/10.1590/0074-02760210280

Gene sequence analysis of toxins from the spider Phoneutria nigriventer revealed an intronless feature
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Paiva, Ana Luiza Bittencourt

; Matavel, Alessandra

; Silva, Bruno César Souza

; Guerra-Duarte, Clara

; Diniz, Marcelo Ribeiro Vasconcelos

Journal of Venomous Animals and Toxins including Tropical Diseases

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2020, Volume 26 elocation e20190075

Abstract: En | Text: En | PDF: En

Abstract Background: Phoneutria nigriventer spider venom contains several cysteine-rich peptide toxins that act on different ion channels. Despite extensive studies on its venom and description of cDNA sequences of several of its toxin precursors, the gene structure of these toxins remains unknown. Methods: Genomic regions encoding the precursors of three previously characterized P. nigriventer toxins - PnTx1, PnTx2-5 and PnTx4(5-5) - were amplified by PCR using specific primers. PCR fragments were cloned and sequenced. Obtained sequences were compared with their corresponding cDNA sequences. Results: The size of PCR fragments obtained and sequences corresponding to genomic regions encoding for the toxin precursors matched their cDNA sequences. Conclusions: Despite a few nucleotide substitutions in the genomic regions encoding for the toxin precursors when compared with cDNA sequences, the results of the present work indicate that P. nigriventer toxins do not contain introns in their genes sequences.

https://doi.org/10.1590/1678-9199-jvatitd-2019-0075 908 downloads

Surgical results of remnant gastric cancer treatment
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RAMOS, MARCUS FERNANDO KODAMA PERTILLE

; PEREIRA, MARIA CLAUDIA MACHADO

; OLIVEIRA, YARA SOUZA

; PEREIRA, MARINA ALESSANDRA

; BARCHI, LEANDRO CARDOSO

; DIAS, ANDRE RONCON

; ZILBERSTEIN, BRUNO

; RIBEIRO JUNIOR, ULYSSES

; CECCONELLO, IVAN

Revista do Colégio Brasileiro de Cirurgiões

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2020, Volume 47 elocation e20202703

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: o câncer do coto ou remanescente gástrico (CRG) se desenvolve cinco anos ou mais após a ressecção gástrica por lesão benigna ou maligna. O tratamento é realizado através da gastrectomia total complementar (GTC) com linfadenectomia. Alguns relatos consideram que esse procedimento pode estar associado a maiores taxas de morbimortalidade. Objetivo: avaliar os resultados cirúrgicos e a sobrevida após GTC em pacientes com CRG. Métodos: 54 pacientes submetidos a GTC entre 2009 e 2019 foram incluídos no estudo. Como grupo de comparação, foram selecionados 215 pacientes com câncer gástrico primário (CGP) submetidos à gastrectomia total (GT) no mesmo período. Resultados: dentre as características iniciais, a idade média (68,0 vs. 60,5; p <0,001), os valores de hemoglobina (10,9 vs. 12,3; p <0,001) e o índice de massa corporal (22,5 vs. 24,6; p = 0,005) diferiram entre os grupos CRG e CGP, respectivamente. As complicações pós-operatórias mais frequentes foram pulmonares, infecciosas e fístulas nos dois grupos. Houve maior incidência de fístula esofagojejunal no grupo GTC (14,8% vs 6,5%, p = 0,055). A mortalidade perioperatória foi maior nos pacientes com CRG (9,3% vs. 5,1%), mas sem significância (p = 0,329). O tempo de internação hospitalar, complicações pós-operatórias (Clavien-Dindo), mortalidade aos 30 e 90 dias não foram diferentes entre os grupos. Não houve diferença significativa na sobrevida livre de doença e global entre os grupos CRG e CGP. Conclusão: apesar dos relatos anteriores, os resultados cirúrgicos e a sobrevida foram semelhantes entre os grupos. Maior risco de fístula esofagojejunal dever ser considerado.

ABSTRACT Background: remnant gastric cancer (RGC) develops five years or later after previous resection for benign or malignant lesion. The treatment is performed through completion total gastrectomy (CTG) with radical lymphadenectomy. Some reports consider this procedure may be associated with higher rates of morbidity and mortality. Objective: to evaluate surgical results and survival after CTG in patients with RGC. Methods: 54 patients who underwent CTG between 2009 and 2019 were included in the study. As a comparison group 215 patients with primary gastric cancer (PGC) who underwent total gastrectomy (TG) in the same period were selected. Results: among the initial characteristics, age (68.0 vs. 60.5; p<0.001), hemoglobin values (10.9 vs. 12.3; p<0.001) and body mass index (22.5 vs. 24.6; p=0.005) were different between the RGC and PGC groups, respectively. The most frequent postoperative complications were related to pulmonary complications, infection and fistula in both groups. There was a higher incidence of esophagojejunal fistula in the CTG group (14.8% vs 6.5%, p=0.055). Perioperative mortality was higher in RGC patients (9.3% vs. 5.1%), but without significance (p=0.329). Hospital length of stay, postoperative complications graded by the Clavien-Dindo classification, mortality at 30 and 90 days were not different between groups. There was no significant difference in disease-free and overall survival between RGC and PGC groups. Conclusion: despite previous reports, surgical results and survival were similar between groups. Higher risk of esophagojejunal fistula must be considered.

https://doi.org/10.1590/0100-6991e-20202703 677 downloads

Análise do potencial de aproveitamento energético de biogás de aterro e simulação de emissões de gases do efeito estufa em diferentes cenários de gestão de resíduos sólidos urbanos em Varginha (MG)
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Souza, Alessandra Ribeiro de

; Silva, Alex Takeo Yasumura Lima

; Trindade, Aline Bhering

; Freitas, Flávio Ferreira

; Anselmo, Jaíne Alves

Engenharia Sanitaria e Ambiental

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oct 2019, Volume 24 N. 5 Pages 887 - 896

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O presente trabalho propõe avaliar a viabilidade econômica e ambiental de aproveitamento energético do biogás do aterro sanitário do município de Varginha (MG), além de analisar as emissões de gases de efeito estufa (GEE) e o uso de energia em diferentes cenários hipotéticos de gerenciamento de resíduos sólidos urbanos (RSU). Considerou-se uma projeção de geração de RSU em 20 anos de funcionamento do aterro, cuja produção de biogás foi estimada por meio do software LandGEM©. A análise de viabilidade econômica foi realizada por meio dos indicadores de valor presente líquido (VPL) e taxa interna de retorno (TIR). As emissões de GEE foram estimadas aplicando-se o modelo Waste Reduction Model (WARM©), considerando o cenário atual e três cenários alternativos de gerenciamento de RSU. Os cenários diversificaram em estratégias de reciclagem, digestão anaeróbia, incineração e disposição em aterro, com recuperação energética. Somente o aproveitamento energético com potência de 150 kW resultou em viabilidade econômica. Já os maiores benefícios ambientais foram obtidos pelo cenário 3, baseado na recuperação de materiais recicláveis, digestão anaeróbia e incineração dos RSU, reduzindo consideravelmente o volume de RSU destinados ao aterro. Dentre as práticas de gerenciamento dos cenários propostos, a reciclagem obteve os maiores ganhos energéticos e remoção de emissões de GEE.

ABSTRACT The present work proposes to evaluate the economic and environmental viability of energy recovery from biogas in the landfill of Varginha-MG, as well to analyze greenhouse gas emissions (GHG) and energy consumption in different scenarios of municipal solid waste (MSW) management. A 20-year projection of MSW generation and landfill operation were considered, whose biogas production was estimated through LandGEM software. The economic feasibility analysis was performed using the net present value (NPV), and the internal rate of return (IRR) as indicators. GHG emissions were estimated by applying the WARM model (Waste Reduction Model) considering the current MSW management scenario and three alternative ones. The scenarios diversified into recycling strategies, anaerobic digestion, landfill disposal and incineration with energy recovery. Only the energy recovery with a power of 150 kW resulted in economic viability. Moreover, the largest environmental benefits were obtained by scenario 3, based on the recovery of recyclable materials, anaerobic digestion and incineration of MSW, considerably reducing the volume of MSW landfilled. Among all management practices of the proposed scenarios, recycling resulted in greater energy gains and GHG emission removal.

https://doi.org/10.1590/s1413-41522019187066 2815 downloads

10.

Detecção de inibidores de proteases em sementes de Punica granatum
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Colares, Lara Franca

; Santos Neto, Antero Ricardo

; Cordeiro, Isac Henrique

; Castro, Sandra Bertelli Ribeiro de

; Verly, Rodrigo Moreira

; Alves, Caio Cesar de Souza

; Carli, Alessandra de Paula

Química Nova

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apr 2017, Volume 40 N. 3 Pages 270 - 274

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation. Protease inhibitors are compounds that can decrease activity of an enzyme. They are found in plants, especially in Fabaceae, Poaceae, and Solanaceae families, and show satisfactory use to treat diseases due to their regulatory activities and selective proteolytic degradation of target substrates. This study aimed to obtain protease inhibitors in the seeds of Punica granatum, due its use in traditional medicine. The alcohol-acid solution was used to extract and isolate the protease inhibitors in P. granatum seeds and Glycine max grains. The extract of P. granatum seeds showed similar concentration of protease inhibitors when compared to G. max. A 14 kDa band was detected by electrophoresis on polyacrylamide gel, which was characterized by high-performance liquid chromatography as protease inhibitors. The extract of P. granatum seeds showed a potent trypsin inhibitor activity (EC50 18.2 ng mL-1). This study showed for the first time the extraction, purification, and identification of protease inhibitors in Punica granatum seeds.

https://doi.org/10.21577/0100-4042.20160189 1218 downloads

11.

Physical activity, BMI and metabolic risk in Portuguese adolescents
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Santos, Fernanda Karina dos

; Gomes, Thayse Natacha Queiroz Ferreira

; Souza, Michele Caroline de

; Chaves, Raquel Nichele

; Santos, Daniel Monteiro de Vilhena e

; Pereira, Sara Isabel Sampaio

; Borges, Alessandra da Silva

; Maia, José António Ribeiro

Revista Brasileira de Cineantropometria & Desempenho Humano

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feb 2016, Volume 18 N. 1 Pages 103 - 113

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Tem-se verificado, nas últimas décadas, uma redução substancial nos níveis de atividade física (AF), com o consequente aumento da prevalência de sobrepeso/obesidade e fatores de risco metabólico entre jovens. O presente estudo teve por objetivos identificar os níveis de AF e as prevalências de sobrepeso/obesidade e risco metabólico, e associar o índice ponderal com os níveis de AF e risco metabólico em jovens portugueses. A amostra foi composta por 212 jovens portugueses (12-16 anos). Estatura e peso foram mensurados. AF foi estimada a partir do recordatório de 3 dias de Bouchard e pelo uso do pedômetro (durante 5 dias). Os indicadores de risco metabólico considerados foram: glicose, triglicerídeos, HDL-colesterol, tensão arterial sistólica e perímetro da cintura. Os sujeitos foram classificados consoante índice ponderal a partir do índice de massa corporal, enquanto que o estatuto maturacional foi estimado a partir do offset maturacional. Score contínuo de risco metabólico (zRM) foi calculado, e a AF foi dividida em tercis. Os testes estatísticos utilizados foram o Qui-quadrado, teste t independente e ANOVA, as análises foram conduzidas no SPSS 18.0 e WinPepi (p<0,05). Observou-se uma prevalência moderada a elevada de sobrepeso/obesidade e HDL-colesterol, uma elevada prevalência de risco para tensão arterial, e níveis de AF baixos a moderados entre jovens portugueses. A relação entre índice ponderal e zRM mostrou que adolescentes obesos apresentam maior zRM comparativamente aos adolescentes normoponderais ou com sobrepeso. Incrementos nos níveis de AF e redução da prevalência de sobrepeso/obesidade podem ter um papel relevante na redução de fatores de risco metabólico.

Abstract It has been reported, in the last decades, a significant decrease in physical activity (PA) levels, with a consequent increase in obesity and metabolic risk factors among youth. The aims of this study were to describe PA levels, the prevalence of overweight/ obesity and metabolic risk factors, and to examine the association between PA and body mass index (BMI) with metabolic risk among Portuguese youth. The sample comprises 212 Portuguese adolescents (12-16 years old). Height and weight were measured. PA was estimated with the Bouchard questionnaire (3 days recall), as well as with the use of a pedometer (used for 5 consecutive days). Metabolic risk factors comprised fasting glucose, triglycerides, HDL-cholesterol, systolic blood pressure and waist circumference. Subjects were classified as normal weight, overweight or obese according to BMI; the maturational status was indirectly estimated with the maturity offset procedure. A continuous metabolic risk score was computed (zMR) and PA values were divided into tertiles. Quisquare test, t-test and ANOVA were used in statistical analyses. SPSS 18.0 and WinPepi softwares were used and p<0.05. A moderate to high prevalence of overweight/obesity and HDL-cholesterol was found, as well as a high prevalence of high blood pressure and low to moderate PA levels among Portuguese youth. The relationship between BMI and zMR showed that obese adolescents have higher zMR when compared to normal weight or overweight adolescents. This finding suggests that increased levels of PA and reduction in the prevalence of overweight/obesity may have a positive role against the development of metabolic risk factors.

https://doi.org/10.5007/1980-0037.2016v18n1p103 2634 downloads

12.

Influência do canto coral na qualidade de vida em voz dos usuários do serviço público de saúde
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Lobo, Bárbara Pereira Lopes

; Gomes, Adriana Maria de Lima e Souza

; Santos, Alessandra Mara Oliveira dos

; Klein, Matheus de Souza

; Rocha, Camila Lacerda Silveira

; Silva, Juliane Ribeiro da

Revista CEFAC

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oct 2015, Volume 17 N. 5 Pages 1573 - 1579

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: OBJETIVO: investigar a qualidade de vida relacionada à voz de participantes de um grupo de canto promovido por profissionais do sistema público de saúde. MÉTODOS: o estudo foi realizado com 86 indivíduos de ambos os sexos, dos quais 46 compunham o grupo controle e 40, o grupo em estudo, cujos usuários participavam do grupo de canto. Os participantes preencheram o questionário de Qualidade de Vida em Voz validado para o português brasileiro. Para verificar a diferença entre as médias dos grupos foi utilizado o teste não paramétrico de Mann-Whitney, com significância < 0,05. RESULTADO: as médias de idade dos grupos foram 58,95 anos para o grupo controle e 60,82 anos para o grupo estudo, não havendo diferença estatística entre as médias. Tanto os escores totais, quanto os relacionados a cada domínio separadamente, se mostraram bem semelhantes entre os grupos, não tendo sido encontrada diferença significante (p=0,9295). Além disso, foi verificado que o tempo de permanência no grupo EnCanto não influenciou no resultado dos escores. CONCLUSÃO: não houve diferença significante entre os escores dos grupos, o que pode ter sido influenciado pelo fato de ambos já apresentarem escores dentro da normalidade. Semelhantemente, os escores não foram diferenciados pelo tempo de permanência no grupo EnCanto, podendo estar relacionado à influência antagônica causada pelo processo de presbilaringe, por se tratar de uma população predominantemente idosa. Entretanto, são necessários novos estudos.

Abstract: PURPOSE: to investigate the voice-related quality of life of participants in a singing group organized by public health system professionals. METHODS: the study was conducted with 86 individuals of both genders, of which 46 were part of the control group, and 40 the study group, whose members participated in a singing group. Participants completed the questionnaire Voice-Related Quality of Life validated in Brazilian Portuguese. To verify the difference between the groups' averages we used the nonparametric Mann-Whitney test, with significance < 0.05. RESULT: the age averages of the groups were 58.95 years for the control group and 60.82 years for the study group, with no statistical difference between the averages. Both the total score and those related to each area separately, proved very similar among groups, and there was no significant difference found (p = 0.9295). In addition, it has been verified that the length of stay in the Encanto group did not influence the outcome of the scores. CONCLUSION: there was no significant difference between the scores of the groups, which may have been influenced by the fact that both have presented scores within the normal range. Similarly, the scores were not differentiated by length of stay in the Encanto group, which may be related to the antagonistic influence caused by the presbylarynx process, because of the predominantly elderly population. However, further studies are needed.

https://doi.org/10.1590/1982-021620151756615 2561 downloads

13.

Tools used for evaluation of Brazilian children's quality of life
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Souza, João Gabriel S.

; Pamponet, Marcela Antunes

; Souza, Tamirys Caroline S.

; Pereira, Alessandra Ribeiro

; Souza, Andrey George S.

; Martins, Andréa Maria E. de B. L.

Revista Paulista de Pediatria

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jun 2014, Volume 32 N. 2 Pages 272 - 278

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

OBJETIVO:Realizar uma revisão da literatura sobre instrumentos utilizados na avaliação da qualidade de vida de crianças, validados para o português e para a cultura brasileira.FONTES DE DADOS: Pesquisaram-se artigos científicos nos portais Medline, Lilacs e SciELO, por meio da combinação dos descritores "qualidade de vida", "criança" e "questionários", além de sua versão em inglês.SÍNTESE DOS DADOS: Dentre os instrumentos criados para avaliar a qualidade de vida em crianças e que foram validados para o português e para a cultura brasileira, destacam-se o Autoquestionnaire Qualité de Vie Enfant Imagé (AUQEI), o Child Health Questionnaire - Parent Form 50 (CHQ-PF50), o Pediatric Quality of Life Inventory (PedsQL(tm)) version 4.0 e o Kidscreen-52. Ressalta-se que alguns instrumentos não contemplam todas as idades da infância ou não possuem domínios considerados relevantes atualmente no contexto da infância, como o bullying. Além disso, devido à diversidade cultural do Brasil, podem ser necessárias adaptações dos instrumentos existentes ou validação de outros.CONCLUSÕES: Constata-se a existência de instrumentos validados no Brasil passíveis de serem utilizados para aferir a qualidade de vida de crianças. No entanto, considera-se a necessidade de adaptar ou validar outros instrumentos internacionais para suprirem as deficiências existentes.

OBJECTIVE:To review the available tools to evaluate children's quality of life validated for Brazilian language and culture.DATA SOURCES: Search of scientific articles in Medline, Lilacs and SciELO databases using the combination of descriptors "quality of life", "child" and "questionnaires" in Portuguese and English.DATA SYNTHESIS: Among the tools designed to assess children's quality of life validated for the Brazilian language and culture, the Auto questionnaire Qualité de Vie Enfant Imagé (AUQEI), the Child Health Questionnaire - Parent Form 50 (CHQ-PF50), the Pediatric Quality of Life Inventory (PedsQL(tm))version 4.0 and the Kidscreen-52 are highlighted. Some tools do not include all range of ages and some lack domains that are currently considered relevant in the context of childhood, such as bullying. Moreover, due to the cultural diversity of Brazil, it may be necessary to adapt some instruments or to validate other tools.CONCLUSIONS: There are validated instruments to evaluate children's quality of life in Brazil. However, the validation or the adaptation of other international tools have to be considered in order to overcome current deficiencies

OBJETIVO: Realizar una revisión de la literatura sobre instrumentos utilizados en la evaluación de la calidad de vida de niños, validados para el Portugués y para la cultura brasileña.FUENTES DE DATOS: Se investigaron artículos científicos en los portales Medline, Lilacs y SciELO, utilizando la combinación de descriptores "calidad de vida", "niño" y "cuestionarios", además de su versión en inglés. La búsqueda bibliográfica no se limitó a un periodo específico.SÍNTESIS DE LOS DATOS: Entre los instrumentos creados para evaluar la calidad de vida en niños y que fueron validados para el Portugués y para la cultura brasileña, se destacan el Autoquestionnaire Qualité de Vie Enfant Imagé (AUQEI), el Child Health Questionnaire - Parent Form 50 (CHQ-PF50), el Pediatric Quality of Life Inventory (PedsQL(tm)) version 4.0 y el Kidscreen-52. Se subraya que algunos instrumentos no contemplan todas las edades de la infancia o no poseen dominios considerados relevantes actualmente en el contexto de la infancia, como el bullying. Además, debido a la densidad cultural de Brasil, puede que sean necesarias adaptaciones de los instrumentos existentes o validación de otros.CONCLUSIONES: Se constata la existencia de instrumentos validados en Brasil pasibles de utilizarse para verificar la calidad de vida de niños. Sin embargo, se considera la necesidad de crear o validar otros instrumentos internacionales para suplir las necesidades existentes.

https://doi.org/10.1590/0103-0582201432214313 17867 downloads

14.

Estado nutricional pré-gestacional, ganho de peso materno, condições da assistência pré-natal e desfechos perinatais adversos entre puérperas adolescentes
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Santos, Marta Maria Antonieta de Souza

; Baião, Mirian Ribeiro

; Barros, Denise Cavalcante de

; Pinto, Alessandra de Almeida

; Pedrosa, Priscila La Marca

; Saunders, Claudia

Revista Brasileira de Epidemiologia

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mar 2012, Volume 15 N. 1 Pages 143 - 154

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Identificar associação entre estado nutricional pré-gestacional, ganho ponderal materno e condições do pré-natal com os desfechos prematuridade e baixo peso ao nascer (BPN) em filhos de mães adolescentes. MÉTODOS: Estudo transversal com 542 pares de puérperas adolescentes e conceptos atendidos em uma maternidade pública do município do Rio de Janeiro (RJ). Os dados foram coletados em prontuários. Para verificar a associação entre as variáveis independentes e os desfechos estudados, foram estimados a odds ratio (OR) e o intervalo de confiança (IC) de 95%. RESULTADOS: Quanto ao estado nutricional pré-gestacional das adolescentes, 87% apresentavam eutrofia, 1% baixo peso, 10% sobrepeso e 2% obesidade. A inadequação do ganho de peso gestacional total (72%) superou a adequação (28%). O peso ao nascer foi favorecido com maior ganho de peso gestacional e reduzido com início tardio do pré-natal (PN). A comparação entre os grupos de conceptos com baixo peso e com peso adequado ao nascer revelou diferenças significativas entre as médias das variáveis: intervalo entre a última gestação e a atual (p = 0,022); peso pré-gestacional (p = 0,018); índice de massa corporal pré-gestacional (p < 0,001) e ganho de peso gestacional total (p = 0,047). As chances de BPN (OR 2,70; IC 95% 1,45 - 5,06) e de prematuridade (OR 5,82; IC 95% 3,10 - 10,92) reduziram quando a adolescente recebeu 6 ou mais consultas de PN. CONCLUSÃO: O peso ao nascer foi relacionado ao intervalo intergestacional, ao peso pré-gestacional e ao índice de massa corporal pré-gestacional. A frequência mínima de 6 consultas de assistência pré-natal constituiu-se em fator de proteção contra o BPN e a prematuridade.

OBJECTIVE: To identify the association between pre-gestational nutritional status, maternal weight gain, and prenatal care with low birth weight (LBW) and prematurity outcomes in infants of adolescent mothers. METHODS: Cross-sectional study with 542 pairs of adolescent mothers and their children attending a public maternity hospital in Rio de Janeiro. Data were collected from medical records. To determine the association between independent variables and the outcomes studied, odds ratio (OR) and a 95% confidence interval (CI) were estimated RESULTS: With respect to pre-pregnancy nutritional status of adolescents, 87% had normal weight, 1% were underweight, 10% were overweight, and 2% obese. Inadequate total gestational weight gain (72%) exceeded adequacy (28%). Birth weight was favored with greater gestational weight gain, and reduced with late onset of prenatal care. The comparison between the low birth weight and normal birth weight groups revealed significant differences between variable means: interval between the past pregnancy and current pregnancy (p = 0.022), pre-gestational weight (p = 0.018); pre-gestational body mass index (p < 0.001), and total gestational weight gain (p = 0.047). The odds of LBW (OR 2.70, 95% CI 1.45 to 5.06) and prematurity (OR 5.82, 95% CI 3.10 to 10.92) fell when the adolescent received six or more prenatal visits. CONCLUSION: Birth weight was associated with inter-gestational interval, pre-pregnancy weight and body mass index before pregnancy. The minimum frequency of six prenatal care visits was a protective factor against LBW and prematurity.

6881 downloads Cited 1 time in SciELO

15.

PET-Saúde: uma experiência prática de integração ensino-serviço-comunidade
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Ferreira, Vinicius Santos

; Barreto, Renata Lavigne Moniz

; Oliveira, Emilie Kruschewskt

; Ferreira, Pedro Rafael Farias

; Santos, Laryssa Passos Sarmento

; Marques, Vitor Eduardo Andrade

; Souza, Monaliza Lemos de

; Menezes, Vanessa Valverde

; Soares, Karla Thayse Mendes

; Oliveira, Laís Ribeiro

; Souza, Lorena Marinho de

; Mendes, Rízia de Melo

; Pinto, Edmundo P.

; Bittencourt, Maria

; Tapioca, Silvana

; Almeida, Rita de Cássia S.

; Linhares, Andréa

; Farias, Alessandra

; Santana, Meire Núbia S. de

Revista Brasileira de Educação Médica

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mar 2012, Volume 36 N. 1 Pages 147 - 151

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este trabalho relata a experiência de integração ensino-serviço-comunidade vivenciada por membros de equipes de Saúde da Família e graduandos de Medicina e Enfermagem participantes do PET-Saúde da Universidade Estadual de Santa Cruz. A referida integração contextualizou-se com o desenvolvimento do projeto "Unidos contra a dengue", mobilização conjunta da instituição de ensino com o serviço de saúde e a comunidade no combate à dengue no bairro Nossa Senhora da Vitória, Ilhéus-Bahia. O foco das ações desse projeto foram as atividades de educação em saúde, nas quais se empregou preferencialmente metodologias ativas de ensino e aprendizagem. A mobilização contou com a participação expressiva da população das mais diversas faixas etárias. O sucesso do projeto ressalta a importância da implantação de programas como o PET-Saúde, que fortalecem a interação entre ensino-serviço-comunidade - importante para construção de serviços de saúde mais qualificados, capazes de inter-relacionar promoção, prevenção e assistência à saúde, possibilitando ações nessa área mais próximas das reais necessidades do SUS. Com esta experiência, espera-se ter contribuído para a formação de graduandos em saúde e qualificação em serviço de profissionais dessa área mais dispostos a trabalhar de forma integrada e integradora com a comunidade.

This study reports on a practical experience with the integration between learning, services, and the community including members of family health teams and undergraduate medical and nursing students participating in the Educational Program for Health Work (PET-Saúde) at Santa Cruz State University. The integration took place within the context of the project "United Against Dengue", an integrated mobilization of the teaching institution, health services, and community in the fight against dengue fever in the district of Nossa Senhora da Vitória, Ilhéus, Bahia State. The projects focused on health education activities, especially with active teaching and learning methods. The mobilization included a significant range of age groups. The project's success emphasizes the importance of implementing programs such as PET-Saúde that strengthen the interaction between learning, services, and the community, important for developing more qualified health services with the capacity to interrelate health promotion, prevention, and healthcare, fostering health activities more in line with the needs of the Unified National Health System (SUS). This experience aims to contribute to the qualification and training of health professionals and students that are willing to work in an integrated and integrating approach with the community.

10419 downloads Cited 5 times in SciELO

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