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Resumen Introducción: el progreso en los tratamientos para el lupus eritematoso sistémico (LES) resultó en una disminución de la mortalidad; sin embargo, la enfermedad cardiovascular y las complicaciones infecciosas aún son las principales causas de muerte. La evidencia apoya la participación del sistema inmunológico en la generación de la placa aterosclerótica, así como su conexión con las enfermedades autoinmunes. Objetivos: describir la frecuencia de eventos cardiovasculares (ECV) en el Registro de Lupus Eritematoso Sistémico de la Sociedad Argentina de Reumatología (RELESSAR) transversal, así como sus principales factores de riesgo asociados. Materiales y métodos: estudio descriptivo y transversal para el cual se tomaron los pacientes ingresados en el registro RELESSAR transversal. Se describieron las variables sociodemográficas y clínicas, las comorbilidades, score de actividad y daño. ECV se definió como la presencia de al menos una de las siguientes patologías: enfermedad arterial periférica, cardiopatía isquémica o accidente cerebrovascular. El evento clasificado para el análisis fue aquel posterior al diagnóstico del LES. Se conformaron dos grupos macheados por edad y sexo 1:2. Resultados: 1515 pacientes mayores de 18 años participaron del registro. Se describieron 80 pacientes con ECV (5,3%). En este análisis se incluyeron 240 pacientes conformando dos grupos. La edad media fue de 47,8 (14,4) y 47,6 (14,2) en el grupo con y sin ECV respectivamente. Los pacientes con ECV tuvieron mayor duración del LES en meses, mayor índice de Charlson, mayor SLICC (Systemic Lupus International Collaborating Clinics/American College of Rheumatology), mayor frecuencia de manifestaciones neurológicas, síndrome antifosfolípido, hospitalizaciones y uso de ciclofosfamida. Las únicas variables asociadas en el análisis multivariado fueron el índice de Charlson (p=0,004) y el SLICC (p<0,001). Conclusiones: los ECV influyen significativamente en nuestros pacientes, y se asocian a mayor posibilidad de daño irreversible y comorbilidades.

Abstract Introduction: progress in treatments for systemic lupus erythematosus (SLE) has resulted in a decrease in mortality; however, cardiovascular and infectious diseases remain the leading causes of death. Evidence supports the involvement of the immune system in the generation of atherosclerotic plaque, as well as its connection to autoimmune diseases. Objectives: to describe the frequency of cardiovascular disease (CVD) in the cross-sectional RELESSAR registry, as well as its associated variables. Materials and methods: a descriptive and cross-sectional study was performed using patients admitted to the cross-sectional RELESSAR registry. Sociodemographic variables, clinical variables, comorbidities, activity and damage scores were described. CVD was defined as at least one of the following: peripheral arterial disease, ischemic heart disease, or cerebrovascular accident. All patients with at least one CVD were included in our analysis (heart attack, central nervous system vascular disease, and peripheral arteries atherosclerotic disease). The event classified for the analysis was that after the diagnosis of SLE. SLE diagnosis was previous to CVD. Two groups matched by age and sex, 1:2 were formed. Results: a total of 1515 patients older than 18 years participated in the registry. Eighty patients with CVD (5.3%) were described in the registry. Two-hundred and forty patients were included, according to two groups. The mean age was 47.8 (SD 14.4) and 47.6 (SD 14.2) in patients with and without CVD, respectively. Patients with CVD had a longer duration of SLE in months, a higher Charlson index, a higher SLICC, increased frequency of neurological manifestations, antiphospholipid syndrome, hospitalizations, and use of cyclophosphamide. The associated variables in the multivariate were the Charlson Index (p=0.004) and the SLICC (p<0.001). Conclusions: CVDs have a significant influence on our patients, being associated with a greater possibility of damage and comorbidities.

https://doi.org/10.47196/rar.v34i2.747

Validación de clasificaciones de pie diabético en Argentina
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Carro, Gabriela Verónica

; Saurral, Rubén Nicolás

; Issa, Claudia Marcela

; Witman, Érica Lorena

; Braver, José Daniel

; Casen, María Alejandra

; David, Raúl Alejandro

; Dituro, Claudio Fabián

; Torres, Julio César

; Illuminati, Gabriela Silvana

; Alterini, Pablo

; Losada, María Victoria Dicatarina

; Badías, Florencia

; Romero, Élida Beatriz

; Kremer Sendros, Sandra Aixa

; Vega, Walter Agustín

; Méndez, Elizabet

; Carrió, Luisa Mabel

Revista de la Sociedad Argentina de Diabetes

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aug 2023, Volume 57 N. 2 Pages 84 - 94

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: las clasificaciones de pie diabético (PD) son una herramienta que tienen el objetivo de mejorar la comunicación entre los profesionales, la referencia y contrarreferencia; proporcionar un pronóstico; ayudar en la valoración de las lesiones, y contribuir con fines estadísticos. Objetivos: describir las características de los pacientes que se presentaron al consultorio o a la guardia con un PD durante un período de 3 meses, determinar el riesgo según cinco clasificaciones (Texas, IDSA, San Elián, WIfI y SINBAD) y evaluar su evolución a 6 meses en relación con el grado de gravedad determinada por cada clasificación. Materiales y métodos: se analizaron 312 pacientes de 15 instituciones en Argentina. Para el análisis se utilizó la calculadora de clasificaciones de pie diabético/score de riesgo del Comité de Pie Diabético de la Sociedad Argentina de Diabetes. Resultados: el 43% de los pacientes (n=133) requirió internación al momento de la primera consulta y el 61% (n=189) había consultado previamente. El porcentaje de amputación mayor total fue de 8,33% (IC 95%; 5,5-11,9) (n=26) y el de amputación menor de 29,17% (IC 95%; 24,2-34,6) (n=91). A los 6 meses, el porcentaje de muerte fue de 4,49% (IC 95%; 2,5-7,4) (n=14), el 24,3% (IC 95%;19,6-29,5) presentaba la herida aún abierta (n=76), el 58,0% (IC 95%; 52,3-66,5) (n=181) cicatrizó y el 7,37% se perdió del seguimiento (n=23). Las clasificaciones de San Elián y WIfI se relacionaron con amputación mayor, cicatrización y muerte. En relación a la clasificación de Texas, el 49% de los pacientes presentó herida penetrante a hueso o articulación (Texas 3), con o sin infección. El 65,3% de las amputaciones mayores y el 78,6% de las muertes se produjeron en pacientes con isquemia. El punto de corte de San Elián para amputación mayor fue 20. Conclusiones: conocer los datos locales permite organizar los recursos para mejorar la atención de los pacientes.

Abstract Introduction: the classifications of diabetic foot (DF) are a tool that aims to improve communication between professionals, referral and counter-referral, provide a prognosis, help in the assessment of lesions, and contribute to statistical purposes. Objectives: to describe the characteristics of patients who presented to the clinic or emergency department with DF over a period of 3 months, determine the risk according to 5 classifications (Texas, IDSA, SEWSS, WIfI, and SINBAD), and evaluate their evolution at 6 months in relation to the severity degree determined by each classification. Materials and methods: 312 patients from 15 institutions in Argentina were analyzed. The Diabetic Foot Classification Calculator/Risk Score from the Diabetic Foot Committee of the Argentina Argentina Diabetes Society was used for the analysis. Results: 43% of patients (n=133) required hospitalization at the time of the first consultation and 61% (n=189) had previously consulted. The total major amputation percentage was 8.33% (95%CI; 5.5-11.9) (n=26), and the minor amputation percentage was 29.17% (95% CI; 24.2-34.6) (n=91). At 6 months, the death rate was 4.49% (95% CI; 2.5-7.4) (n=14), 24.3% (95% CI; 19.629.5) had an open wound (n=76), 58.0% (95% CI; 52.3-66.5) (n=181) had healed, and 7.37% were lost to follow-up (n=23). The SEWSS and WIfI classifications were related to major amputation, healing, and death. Regarding the Texas classification, 49% of patients had a penetrating wound to bone or joint (Texas 3), with or without infection. 65.3% of major amputations and 78.6% of deaths occurred in patients with ischemia. The SEWSS cut-off point for major amputation was 20. Conclusions: knowing local data allows organizing resources to improve patient care.

Recomendaciones de práctica clínica: diagnóstico de osteomielitis en pie diabético
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Carro, Gabriela Verónica

; Saurral, Rubén Nicolás

; Méndez, Elizabet Gladys

; Dituro, Claudio Fabián

; Varela, Cristina

; David, Raúl Alejandro

; Witman, Érica Lorena

; Torres, Julio Cesar

; Iluminati, Gabriela Silvana

; Casen, María Alejandra

; Alterini, Pablo

; Losada, María Victoria Dicatarina

; Kremer Sendros, Sandra Aixa

; Issa, Claudia

; Badías, Florencia

; Braver, José Daniel

; Romero, Elida

; Vega, Walter Agustín

; Carrió, Luisa Mabel

Revista de la Sociedad Argentina de Diabetes

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may 2022, Volume 56 Suppl. 1 Pages 36 - 39

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La osteomielitis (OM) es una complicación de las úlceras en pie diabético que habitualmente es subdiagnosticada y tratada en forma tardía e inadecuada. La demora en el tratamiento de estos pacientes aumenta el riesgo de amputación. En esta revisión, se analiza la bibliografía actual acerca del diagnóstico de OM y se realizan recomendaciones en base a la misma, y a las características de los pacientes, los insumos y las posibilidades en nuestro medio.

Abstract Diabetic foot osteomyelitis (OM) is a diabetic foot ulcer complication. Usually, it is misdiagnosed and the treatment is delayed and inadequate. Delaying the treatment of these patients rises the risk of amputation. In this revision, current bibliography about this topic is updated and clinical practice recommendations are done, based on the publications and adapted to the characteristics of our country.

Lupus en Argentina. .
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Quintana, Rosana

; García, Lucila

; Gobbi, Carla

; Alba, Paula

; Roverano, Susana

; Álvarez, Analia Patricia

; Graf, César Enrique

; Pisoni, Cecilia

; Spindler, Alberto

; Gómez, Catalina

; Figueredo, Heber Matías

; Papasidero, Silvia

; Paniego, Raúl

; de la Vega, María Celina

; Civit, Emma

; González Lucero, Luciana

; Martire, María Victoria

; Aguila Maldonado, Rodrigo

; Gordon, Sergio

; Micelli, Marina

; Nieto, Romina

; Rausch, Gretel

; Gongora, Vanina

; Damico, Agustina

; Rodríguez Gil, Gustavo

; Dubinsky, Diana

; Orden, Alberto

; Zacariaz, Johana

; Romero, Julia

; Pera, Mariana

; Goñi, Mario

; Rillo, Oscar

; Báez, Roberto

; Arturi, Valeria

; González, Andrea

; Vivero, Florencia

; Bedoya, María Eugenia

; Shmid, María Marcela

; Caputo, Víctor

; Larroude, Maria Silvia

; Domínguez, Nadia

; Gómez, Graciela Noemí

; Rodríguez, Graciela Nora

; Marín, Josefina

; Collado, Victoria

; Jorfen, Marisa

; Bedran, Zaida

; Curti, Ana

; Gazzoni, María Victoria

; Sarano, Judith

; Zelaya, Marcos

; Sacnun, Mónica

; Finucci Curi, Pablo

; Rojas Tessel, Romina

; Arias Saavedra, Maira

; Sattler, María Emilia

; Machado Escobar, Maximiliano Augusto

; Astesana, Pablo

; Paris, Úrsula

; Virasoro, Belén María

; Santa Cruz, María Julia

; Allievi, Alberto

; Vandale, Juan Manuel

; Hojberg, Noelia Giselle

; Pons-Estel, Bernardo

; Pons-Estel, Guillermo

; García, Mercedes Argentina

Revista argentina de reumatología

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mar 2022, Volume 33 N. 1 Pages 14 - 25

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Introduction: lupus is a complex disease and often difficult to approach. Achieving remission is one of the objectives, incorporating therapeutic options. Objectives: to describe the characteristics of the patients and the use of belimumab, according to the status of the disease. Materials and methods: cross-sectional study. Patients of the RELESSAR registry. Stratification: Remission: SLEDAI=0 and without corticosteroids. Low disease activity SLEDAI> 0 and ≤4 and without corticosteroids and non-optimal control: SLEDAI> 4 and any dose of corticosteroids. Results: a total of 1,277 patients were included, 23.4% in remission, 12.6% in low disease activity and 63.8% in non-optimal control. The last group was younger and had a shorter duration of the disease. They had higher activity and chronicity indices and greater use of immunosuppressants. Only 22.3% of the patients with potential criteria for the use of belimumab (activity disease despite standard treatment) were receiving it. The variables associated with hospitalizations were: corticosteroids, cyclophosphamide and higher SLICC. Those associated with severe infection: mycophenolate mofetil, azathioprine, corticosteroids, and higher SLICC. Conclusions: the complexity of the management of these patients is reflected, visualizing structural aspects such as inequality. The use of belimumab could be beneficial in selected patients.

https://doi.org/10.47196/rar.v33i1.602 101 downloads

Capacidad estructural, recursos humanos tecnológicos y requerimientos de ventilación mecánica en 58 unidades de cuidados intensivos en argentina durante la pandemia por SARS-CoV-2. Estudio SATICOVID-19
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Estenssoro, Elisa

; Plotnikow, Gustavo

; Loudet, Cecilia I.

; Ríos, Fernando G.

; Kanoore Edul, Vanina S.

; Andrian, Macarena

; Romero, Ignacio

; Sagardía, Judith

; Bezzi, Marco

; Mandich, Verónica

; Groer, Carla

; Torres, Sebastián

; Orlandi, Cristina

; Birri, Paolo Nahuel

; Rubatto Valenti, María Florencia

; Cunto, Eleonora

; Sáenz, María Gabriela

; Tiribelli, Norberto

; Aphalo, Vanina

; Betttini, Lisandro

; Reina, Rosa

; Dubin, Arnaldo

Medicina (Buenos Aires)

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feb 2022, Volume 82 N. 1 Pages 35 - 46

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract During the SARS-CoV-2 pandemic, there was a marked requirement for critical care beds, supplies and trained professionals to assist patients with severe respiratory failure. The Argentine Society of Intensive Care (SATI) designed a study to characterize these aspects in intensive care units (ICUs). Multicenter, prospective cohort study; the participating ICUs completed a form at the end of the study (31/10/2020) on hospital characteristics, number of beds in pre- and intra-pandemic critical areas, incorporation of professionals, technological resources, and workload. Fifty-eight ICUs participated; 28(48%) were located in Buenos Aires Province, 22(38%) in Buenos Aires Autonomous City and 10 (17%) in other provinces; 31 (53%) of UCIs belonged to the public sector; 23 (47%) to the private-social security. In 35/58 (60%) of the hospitals critical care beds increased from 902 to 1575 (75%), 37% in ICU and 63% mainly in Coronary Care Unit and Emergency-shock room. In 41/55 (75%) UCIs, staff were incorporated: 27(49%) physicians (70% intensivists), 36 (65%) nurses, 28 (51%) respiratory therapists, 20(36%) cleaning staff, and 1(2%) others. A 96% of the ICUS reported having sufficient ventilators and 95% enough sup plies and PPE. Of all patients on invasive mechanical ventilation, 55% [43-64] had COVID-19. Oxygen therapy was required as noninvasive support in 14% [8-24] of COVID-19 admissions. There was a significant expansion of critical operational areas, secondary to the increase in beds, staff, and adequate availability of ventilators and essential supplies. The burden of critical illness from COVID-19 was intense, with more than half of patients on mechanical ventilation.

Resumen Durante la pandemia por SARS-CoV-2 hubo un marcado requerimiento de camas de cuidados críticos, insumos y profesionales entrenados para asistir a pacientes con insuficiencia respiratoria grave. La Sociedad Argentina de Terapia Intensiva (SATI) diseñó un estudio para caracterizar estos aspectos en las Unidades de Cuidados Intensivos (UCIs). Estudio multicéntrico, de cohorte prospectiva; las UCIs participantes completaron un formulario al final del estudio (31/10/2020) sobre características hospitalarias, número de camas de áreas críticas pre- e intra-pandemia, incorporación de profesionales, insumos y recursos tecnológicos, y carga de trabajo. Participaron 58 UCIs; 28(48%) de Provincia de Buenos Aires, 22(38%) de Ciudad Autónoma de Bue nos Aires, 10(17%) de otras; 31(53%) UCIs pertenecían al sector público; 23(47%) al privado-seguridad social. En 35/58(60%) hospitales las camas de cuidados críticos aumentaron de 902 a 1575(75%); 37% en UCI y 63% principalmente en Unidad Coronaria y Emergencias-shock room. En 41/55(75%) UCIs se incorporó personal: 27(49%) médicos/as (70% intensivistas), 36(65%) enfermeros/as, 28(51%) kinesiólogos/as, 20(36%) personal de limpieza, y 1(2%) otros/as; 96% de las UCIS reportaron disponer de respiradores suficientes, y 95%, insumos y EPP suficientes. De todos los pacientes en ventilación mecánica invasiva, 55% [43-64] presentaron COVID-19. Se requirió oxigenoterapia como soporte no invasivo en 14% [8-24] de los ingresos por COVID-19. Se registró una importante expansión de las áreas críticas operativas, secundariamente al aumento de camas, personal, y adecuada disponibilidad de respiradores e insumos esenciales. La carga de la enfermedad crítica por COVID-19 fue intensa, constituyendo más de la mitad de los pacientes en ventilación mecánica.

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Colleters in Cephalanthus (Rubiaceae) and reevaluation of occurrence of corolline colleters in Angiosperms
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ROMERO, MARÍA FLORENCIA

; SALAS, ROBERTO MANUEL

; GONZALEZ, ANA MARIA

Anais da Academia Brasileira de Ciências

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2022, Volume 94 N. 2 elocation e20201975

Abstract: En | Text: En | PDF: En

Abstract Colleters are glandular structures related to young shoots protection. In several Angiosperm families, as in Rubiaceae colleters are taxonomically important. This study reports presence, location, morpho-anatomical structure, ontogeny and histochemistry of colleters in vegetative and reproductive organs in 6 species of Cephalanthus and 20 species representatives of the tribe Naucleeae. Primarily based on their color and their secretion color, they were classified into light (LC) and dark (DC) colleters. The LC are exclusive to the inner side of the stipule, while the DC are found in several vegetative and reproductive organs. Histochemical studies revealed that higher mucilage and phenol content in DC could explain the dark color secretion. Results were analyzed at genus, tribe and subtribe levels, evidencing the taxonomic relevance in the family. Finally, the presence of corolline colleters in angiosperm flowers was reviewed. It was confirmed that, besides Cephalanthus, they are only present in Adenoa (Passifloraceae) and Chamaecrista (Fabaceae). Therefore, structures described as colleters in Nerium (Apocynaceae) and Cuscuta (Cuscutaceae) corollas do not correspond to colleters. This proves that corolline colleter is a rare character in Angiosperms. To conclude we provide a record of presence/absence, type and distribution of corolline colleters in an Angiosperm phylogenetic tree.

https://doi.org/10.1590/0001-3765202220201975

Lectotypification, geographic distribution and conservation status of Cephalanthus glabratus (Naucleeae-Rubiaceae)
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Romero, María Florencia

; Salas, Roberto Manuel

; Gonzalez, Ana María

Rodriguésia

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2021, Volume 72 elocation e01452019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Cephalanthus glabratus é uma espécie imperfeitamente conhecida da família Rubiaceae. Esta é uma planta medicinal muito utilizada pelos habitantes locais em sua área de distribuição, porém até agora tem recebido escassa atenção da comunidade científica, o qual é evidenciado na escassa literatura que trata do táxon. A espécie é um arbusto muito ramificado, com folhas verticiladas, inflorescências em glomérulos, fruto esquizocárpico, uma semente por mericarpo, e sementes com um estrofiolo proeminente e esponjoso. A espécie cresce somente em vegetação de áreas baixas alagáveis e está sempre relacionada às bacias dos principais rios da região, Paraguai, Paraná, Uruguai e Rio da Prata, e, portanto, é fortemente ameaçada pelas atividades humanas ao longo delas (hidrelétricas, desmatamento, avanços das áreas urbanas, redução das zonas úmidas etc.). Seguindo as diretrizes da IUCN e baseado em todos os dados disponíveis de distribuição, classificamos como NT (Near Threatened, quase ameaçada). Apesar de que gênero foi taxonomicamente revisado, a nomenclatura do tipo de Cephalanthus glabratus não foi por enquanto corretamente estudada, portanto, é revisada aqui. Uma descrição detalhada, dados ecológicos e de distribuição são adicionalmente fornecidos.

Abstract Cephalanthus glabratus is an imperfectly known species of the family Rubiaceae. It is a medicinal plant widely used by the locals in its area of distribution, however until now it has received little attention from the scientific community, which is evidenced in the few articles treating the species. The species is a much-branched shrub, with whorled leaves, glomeriform inflorescences, schizocarpic fruits with 1-seeded mericarps, and seeds with a large spongy strophiole. It grows only in the vegetation of the lowlands and is always related to the basins of the main rivers of the region, Paraguay, Paraná, Uruguay and Río de la Plata, and therefore is strongly threatened by the human activities along them (hydroelectric dams, deforestation, advances of urban areas, reduction of the wetlands, etc.). Following IUCN guidelines and all available distributional data, we rated it NT (Near Threatened). Despite the fact that the genus was taxonomically revised, the nomenclatural type of Cephalanthus glabratus was not correctly clarified, so we have done so here. A detailed description, ecological and distributional data are provided.

https://doi.org/10.1590/2175-7860202172045 162 downloads

Orden Commelinales en Aguascalientes, México
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Cabrera-Manuel, Florencia

; Siqueiros-Delgado, María Elena

; Ceja-Romero, Jacqueline

; Sosa-Ramírez, Joaquín

Botanical Sciences

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dec 2020, Volume 98 N. 4 Pages 593 - 611

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background: The Order Commelinales includes five families, 68 genera, and ca. 780 species worldwide; in Mexico, is represented by Commelinaceae, Haemodoraceae and Pontederiaceae. Aguascalientes is located in the center-north region of Mexico, represents an area of floristic transition, between the Mexican Xerophytic region and the Mesoamerican Mountain region, and counts with the families Commelinaceae and Pontederiaceae. Questions and/or Hypothesis: What is the diversity of Commelinales in Aguascalientes? What is the distribution of its species? Studied species: Species of Commelinales in Aguascalientes, Mexico. Study site and dates: Aguascalientes, Mexico. July 2013 to October 2015. Methods: Fifty-two field trips were conducted sampling 142 collection points. A total of 167 specimens were processed and identified with the support of specialist and specialized literature. Additionally, herbaria material from of the region was reviewed and distribution maps were elaborated. Results: Eight genera and 23 species of Commelinales are reported for Aguascalientes, of which six genera and 20 species belong to Commelinaceae, and two genera and three species to Pontederiaceae; eight species are endemic of Mexico; two genera and six species are new records for Aguascalientes; Tradescantia hirsutiflora Bush is a new record for Mexico. Commelinaceae is mainly distributed in the north-eastern part of the state, predominantly in subtropical scrub, whereas Pontederiaceae are aquatic and is mainly distributed in the south-eastern part. Conclusions: This study increases and updates the number of species for Commelinales in Aguascalientes and Mexico, as well as the distribution and types of vegetation in which they are found.

Resumen Antecedentes: El orden Commelinales incluye cinco familias, 68 géneros, y cerca de 780 especies a nivel mundial; en México, está representado por Commelinaceae, Haemodoraceae y Pontederiaceae. Aguascalientes se ubica en la región centro-norte de México, representa una zona de transición florística, entre la región Xerofítica Mexicana y la Mesoamericana de Montaña, y cuenta con las familias Commelinaceae y Pontederiaceae. Preguntas y/o Hipótesis: ¿Cuál es la diversidad de Commelinales en Aguascalientes?, ¿Cuál es la distribución de sus especies? Especies de estudio: Especies de Commelinales en Aguascalientes, México. Sitio y años de estudio: Aguascalientes, México. Julio de 2013 a octubre de 2015. Métodos: Se realizaron 52 recolectas abarcando 142 puntos de muestreo. En total 167 ejemplares fueron recolectados e identificados con el apoyo de especialistas y literatura especializada. Adicionalmente, se revisó material de herbarios de la región y se elaboraron mapas de distribución. Resultados: Se reportan ocho géneros y 23 especies de Commelinales para Aguascalientes, de los cuales seis géneros y 20 especies pertenecen a Commelinaceae, y dos géneros y tres especies a Pontederiaceae; ocho especies son endémicas de México; dos géneros y seis especies son nuevos registros para Aguascalientes; Tradescantia hirsutiflora Bush es nuevo registro para México. Commelinaceae se distribuye principalmente al noreste del estado, predominantemente en matorral subtropical, mientras que Pontederiaceae son acuáticas y se distribuyen principalmente al sureste. Conclusiones: Este estudio amplía y actualiza el número de especies de Commelinales en Aguascalientes y en México, así como la distribución y tipos de vegetación en la que se encuentran.

https://doi.org/10.17129/botsci.2594 377 downloads

Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up
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Méndez, Patricio Chrem

; Calandri, Ismael

; Nahas, Federico

; Russo, María Julieta

; Demey, Ignacio

; Martín, María Eugenia

; Clarens, María Florencia

; Harris, Paula

; Tapajoz, Fernanda

; Campos, Jorge

; Surace, Ezequiel I.

; Martinetto, Horacio

; Ventrice, Fernando

; Cohen, Gabriela

; Vázquez, Silvia

; Romero, Carlos

; Guinjoan, Salvador

; Allegri, Ricardo F.

; Sevlever, Gustavo

Arquivos de Neuro-Psiquiatria

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apr 2018, Volume 76 N. 4 Pages 231 - 240

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT The Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI) study is a longitudinal prospective cohort of 50 participants at a single institution in Buenos Aires, Argentina. Longitudinal assessments on a neuropsychological test battery were performed on 15 controls, 24 mild cognitive impairment (MCI) patients and 12 Alzheimer's disease (AD) dementia patients. In our study population, there was a high prevalence of positive AD biomarkers in the AD group, 92.3% (12/13); and a low prevalence in the normal controls, 20%; almost half (48%) of the patients diagnosed with MCI had positive amyloid detection. After a one year, the significant differences found at baseline on neuropsychological testing were similar at the follow-up assessment even though the AD group had significantly altered its functional performance (FAQ and CDR). The exception was semantic fluency, which showed greater impairment between the AD group and MCI and normal controls respectively. For these tests, the addition of AD biomarkers as a variable did not significantly alter the variations previously found for the established clinical group's model. Finally, the one-year conversion rate to dementia was 20% in the MCI cohort.

RESUMO El estudio de Argentina-Alzheimer's Disease Neuroimaging Initiative (Arg-ADNI) es una cohorte prospectiva de 50 pacientes seguidos en una misma institución. Fueron evaluados cognitivamente 15 controles normales (CN), 24 sujetos con deterioro cognitivo leve (DCL) y 12 con demencia tipo Alzheimer (DTA) leve. En los DTA, 92,3% tuvieron biomarcadores positivos para Alzheimer y 20% en los CN. Casi la mitad de los DCL presentaron biomarcadores positivos. Después de un año de seguimiento, la diferencias significativas halladas en la visita de inicio en las pruebas cognitivas fueron similares al año aunque los DTA tuvieron empeoramiento funcional medido en el FAQ y CDR. La excepción fue la fluencia semántica, la cual mostró mayor declinación entre DTA y los demás grupos. La incorporación de los biomarcadores como variable no alteró significativamente los hallazgos de grupo. La tasa de conversión a demencia anual fue del 20%.

https://doi.org/10.1590/0004-282x20180025 1750 downloads

10.

Insulinorresistencia e hipertensión gestacional: Estudio preliminar en una muestra del Municipio de La Plata
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Suárez Crivaro, Florencia

; Romero, José

; Castrogiovanni, Daniel

; Suescun, María Olga

; Spinedi, Eduardo

Acta bioquímica clínica latinoamericana

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mar 2018, Volume 52 N. 1 Pages 23 - 32

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

As mulheres grávidas com diminuição da sensibilidade à insulina correm o risco de desenvolver distúrbios hipertensivos. Usando o corte HOMA-IR 2,64, a população em estudo foi dividida em dois grupos: (n=154 mulheres grávidas), que deram um HOMA-IR basal (HOMA-0) ≤2,64 (não resistentes à insulina; n=113) e aquelas com HOMA-0 >2,64 (resistentes à insulina, n=41). Foram analisadas: a) as concentrações circulantes de glicose e insulina durante uma prova de tolerância oral a 75 g. de glicose (PTOG), e b) as relações entre diversos parâmetros de sensibilidade à insulina e a predição de desenvolver distúrbios de hipertensão. Foram quantificadas nas mulheres grávidas (24-28 semanas) as concentrações plasmáticas de glicose e insulina a ambos os tempos da PTOG. Valores de HOMA-IR foram calculados e as relações glicose a insulina (G:I) e se registraram parâmetros antropométricos e os resultados da gravidez. Mulheres com HOMA-0 >2,64, mas com glicemias em jejuns normais, mostraram níveis mais elevados de insulinemia e de HOMA-IR, e menores valores G:I em ambos os tempos da PTOG. Essas mulheres grávidas foram aquelas que tiveram maior risco de desenvolver distúrbios de hipertensão e maiores parâmetros de morbidade durante o período estudado em comparação com as mulheres cujo HOMA-0 foi ≤2,64.

Pregnant women with impaired insulin sensitivity are at risk for developing hypertensive disorders. By using a cut-off at 2.64 of the homeostasis model assessment (HOMA-IR) in basal condition (HOMA-0), the population under study (n=154 pregnant women) was split into two groups: 1) with basal HOMA- 0 <2.64 (non-insulin resistant; n=113) and 2) with basal HOMA-0 >2.64 (insulin resistant; n=41). Glucose and insulin circulating levels were analyzed throughout a 2-h oral 75 g glucose tolerance test (OGTT). The relationship between several parameters related to insulin resistance and the prevalence of pregnancy-induced hypertensive disorders was analyzed. Pregnant women (on week 24-28) were submitted to an OGTT, and glucose and insulin plasma concentrations were measured throughout the test. These peripheral metabolites levels and the values of the HOMA-IR and the glucose to insulin ratio (G:I) were analyzed. Anthropometric parameters and pregnancy outcome were recorded. Women with HOMA-0 >2.64 but normal fasting glycemia showed higher insulinemias, G:I values and HOMA-IR values at both times of the OGTT. The latter were at greater risk for developing late pregnancy-induced hypertension compared to women with HOMA-0 ≤2.64.

Las mujeres embarazadas con insulino-sensibilidad disminuida están en riesgo de desarrollar trastornos hipertensivos. Utilizando el corte HOMA-IR en 2,64 la población en estudio fue dividida en dos grupos: (n=154 mujeres embarazadas), las que arrojaron un HOMA-IR basal (HOMA-0) <2,64 (no-insulinorresistentes; n=113) y aquellas con HOMA-0>2,64 (insulinorresistentes, n=41). Se analizaron: a) las concentraciones circulantes de glucosa e insulina durante una prueba de tolerancia oral a 75 g de glucosa (PTOG), y b) las relaciones entre varios parámetros de insulino-sensibilidad y la predicción del desarrollo de trastornos hipertensivos. A las mujeres embarazadas (semana 24-28) se les cuantificaron las concentraciones plasmáticas de glucosa e insulina a ambos tiempos de la PTOG. Se calcularon los valores de HOMA-IR y las relaciones glucosa a insulina (G:I) y se registraron parámetros antropométricos y resultados del embarazo. Las mujeres con HOMA-0 >2,64, aunque con glucemias en ayunas normales, mostraron mayores niveles de insulinemia y de HOMA-IR, y menores valores G:I en ambos tiempos de la PTOG. Estas mujeres embarazadas fueron las que tuvieron un mayor riesgo de desarrollar trastornos hipertensivos y mayores parámetros de morbilidad durante el período estudiado al compararlas con aquellas cuyo HOMA-0 fue <2,64.

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11.

Insuficiencia suprarrenal relativa en pacientes cirróticos
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Orozco, Federico

; Anders, María

; Mella, José

; Antinucci, Florencia

; Pagano, Patricia

; Esteban, Paula

; Cartier, Mariano

; Romero, Gustavo

; Francini, Bettina

; Mastai, Ricardo

Medicina (Buenos Aires)

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aug 2016, Volume 76 N. 4 Pages 208 - 212

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Relative adrenal insufficiency (RAI) is a common finding in cirrhotic patients with severe sepsis, and increased mortality. Its significance is unknown in stable conditions. The aim of this study was to evaluate the prevalence of RAI in stable cirrhotic patients at different stages of the disease. Also, the impact of RAI on the survival was evaluated and basal cortisol levels between plasma and saliva was correlated in control subjects and cirrhotic patients. Forty seven ambulatory patients and 16 control subjects were studied. RAI was defined as a serum cortisol increase of less than 9 μg/dl from baseline after the stimulation with 250 mg of synthetic ACTH. Twenty two had Child-Pugh ≤ 8 and 25 = 9. The prevalence of RAI in patients with stable cirrhosis was 22%. A higher incidence of RAI was observed in patients with a Child-Pugh = 9 (8/32) than in those with ≤ 8 (3/13, p < 0.05). A correlation between salivary cortisol and basal plasma cortisol (r = 0.6, p < 0.0004) was observed. Finally, survival at 1 year (97%) and 3 years (91%) was significantly higher without RAI than those who developed this complication (79% and 51%, p < 0.05, respectively). In summary, the prevalence of RAI is frequent in patients with stable cirrhosis and that it is related to the severity of liver diseaseand increased mortality.

La insuficiencia suprarrenal relativa (ISR) es frecuente en pacientes cirróticos con sepsis grave, asociándose a un pobre pronóstico. Se desconoce su importancia en condiciones de enfermedad estable. El objetivo del trabajo ha sido evaluar la prevalencia de la ISR en una serie de pacientes cirróticos estables y su relación con el deterioro de la función hepática. Se determinó el impacto de la ISR en la supervivencia y se correlacionaron los niveles entre el cortisol basal en plasma y saliva en sujetos controles y cirróticos. Fueron incluidos 47 pacientes ambulatorios y 16 controles. La funcionalidad del eje hipotalámico-pituitario-suprarrenal se valoró mediante la prueba de estimulación con 250 μg de ACTH sintética EV, definiendo la ISR como delta cortisol < 9 μg/dl. Respecto al grado de deterioro de la función hepática, 22 tenían un Child-Pugh ≤ 8 y 25 pacientes = 9. La prevalencia de ISR fue de un 22%, siendo significativamente más elevada en aquellos con mayor deterioro de la función hepática (8/32 vs. 3/13, p < 0.05). Se observó correlación entre el cortisol salival y el plasmático basal (r = 0.6, p < 0.0004). Por último, la supervivencia fue más elevada en los pacientes sin ISR al año (97%) y a los tres años (91%) que aquellos que desarrollaron esta complicación (79 % y 51%, p < 0.05, respectivamente). En resumen, la prevalencia de ISR es elevada en los pacientes con cirrosis estable y se relaciona con un deterioro de la función hepática y una mayor mortalidad.

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12.

Estudios morfo-anatómicos dedomacios foliares en Rubiáceas Argentinas
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Romero, María Florencia

; Salas, Roberto

; Gonzalez, Ana Maria

Boletín de la Sociedad Argentina de Botánica

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dec 2015, Volume 50 N. 4 Pages 493 - 514

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

This paper deals with the study of leaf domatia in Argentine Rubiaceae, which are common morphogenetic structures on the underside of the leaves of woody plants, which can establish mutual relations with mites or ants. Tufts of hair, pockets, cavities and crypts: many families are classified into types common relatively well preserved. Around 290 families of “dicots” have domatia, Rubiaceae being the best represented with all known and transitional types. Domestic classification by molecular data, Rubiaceae divided into three subfamilies: Rubioideae, Ixorideae and Cinchonoideae. In Argentina inhabit 41 genera and 132 species of Rubiaceae, of which 34 are woody (27%). As result, tree domatia types were found: tuft of hair, pockets and crypt, present in 14 species of Rubiaceace. It is mentioned for the first time a domatia in a vine species of Manettia. The results were compared with recent molecular studies; this confirmed the plesiomorphic condition thereof, since different types are common to the three subfamilies almost all the tribes of the family. Based on this sampling, the following tribes completely lack domatia: Anthospermeae, Rubieae, Paederieae and Pavetteae.

Este trabajo estudia los domacios foliares en Rubiáceas argentinas, los cuales son estructuras morfogenéticas frecuentes en el envés de las hojas de plantas leñosas, que permiten establecer relaciones mutualistas con ácaros u hormigas. Se clasifican en tipos relativamente bien conservados comunes a numerosas familias: mechones de pelos, bolsillos, cavidades y criptas. Alrededor de 290 familias de “dicotiledóneas” tienen domacios, siendo Rubiaceae la mejor representada con todos los tipos conocidos y transicionales. La clasificación intrafamiliar según datos moleculares, divide a Rubiaceae en tres subfamilias: Rubioideae, Ixorideae y Cinchonoideae. En Argentina viven 41 géneros y 132 especies de Rubiáceas, de las cuales 34 son leñosas (27%). Como resultado se encontraron tres tipos de domacios: mechón de pelos, bolsillos y en cripta en 14 especies de Rubiáceas. Se menciona por primera vez domacios en una enredadera sufrútice de la familia, en el género Manettia. Los resultados obtenidos fueron contrastados con estudios moleculares recientes, lo que permitió confirmar la condición plesiomórfica de los mismos, ya que los diferentes tipos son comunes a las tres subfamilias y a casi todas las tribus de la familia. Basado en el presente muestreo, las tribus Anthospermeae, Rubieae, Paederieae y Pavetteae carecen completamente de domacios.

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