Resumo: O novo livro de Jurandir Malerba examina os sucessivos projetos formulados para o Brasil, entre meados do século XVIII e as primeiras décadas do século XIX. A resenha busca situar a contribuição desse trabalho à historiografia sobre o período.

Abstract: Jurandir Malerba’s new book examines the successive projects formulated for Brazil, between the middle of the 18th century and the first decades of the 19th century. The review aims to situate the contribution of this work to historiography about the period.

RESUMO A resistência do solo à penetração (RP) é um atributo físico utilizado para quantificar a compactação do solo e a população amostral influenciar na média representativa, induzindo erros. O objetivo do trabalho foi avaliar a RP em Latossolo Vermelho distrófico sob mata nativa e eucalipto. Foram realizadas amostras ao acaso em grupo de 2, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 e 100 a cada 0,10 m do solo até a camada de 0,6 m. Foram calculados os valores médios da RP, o intervalo de confiança e a exatidão da estimativa (D), a 0,05 de significância. Nas condições de estudo foi possível observar que a população apresenta alta confiabilidade, com erros abaixo de 10% e que na área cultivada o número de amostras necessários para avaliação da RP é maior que para o solo sob mata.

ABSTRACT Soil resistance to penetration (RP) is a physical attribute used to quantify soil compaction and the influence of the average representative sample population, causing errors. The objective of this work was to evaluate the RP in distrófico red Latosol under native forest and eucalyptus. Random samples were conducted in groups of 2, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 and 100 every 0.10 m from the ground up to 0.6 m layer. Average values were calculated from the RP, the confidence interval and the accuracy of the estimate (D), the significance of 0.05. Under the conditions of study it was possible to observe that the population has high reliability, with errors below 10% and that in cultivated area the number of samples needed for evaluation of the RP is greater than to the ground under the Woods.

Abstract INTRODUCTION: Newborn who had Zika vírus but did not show microcephaly at birth may have neuropsychomotor development problems. We aimed to evaluate the developmental and anthropometric milestones of asymptomatic children whose mothers had Zika during pregnancy in Northeastern Brazil in 2015 and 2016. METHODS: We conducted a descriptive cross-sectional case series study of children in Fortaleza born without microcephaly whose mothers had Zika during pregnancy. Home visits were undertaken to evaluate the developmental milestones and gather anthropometric data of the children and to conduct semi-structured interviews with the mothers to identify their socioeconomic and gestational profiles and assess the newborns after birth. RESULTS: In total, 30 cases were identified. Of these, 17 children and their mothers participated in the study. The median age of the mothers at the time of delivery was 26 years. All were symptomatic, and TORCH was negative. At the time of the home visit, all had growth profiles suitable for their age. However, nearly all children (15/17, 88.2%) presented at least one developmental delay, considering their age group. CONCLUSIONS: There were late changes in the neuropsychomotor development of children born to mothers who had Zika during pregnancy, suggesting the need for specialized medical follow-ups.

Resumo Este artigo aborda o conceito da corrupção nas sociedades da Época Moderna,indagando sobre a sua pertinência naquele contexto histórico. A partir de uma investigação sobre os significados da palavra corrupção nos textos coevos,propõe-se a refletir sobre as noções que estruturavam o imaginário do mau governo. Considerada um vício,a ambição desmedida dos governantes era objeto de condenação nos textos políticos e morais da época,sendo apontada como uma das causas da corrupção do corpo da República.

Abstract This article discusses the concept of corruption in the societies of the Modern Age, inquiring about their relevance in that historical context. From an investigation into the meanings of the word corruption in coeval texts, it is proposed to reflect on the notions that structured the imaginary about the bad government. Considered a vice, the excessive ambition of rulers was condemnation object in political and moral texts of the time, being considered one of the causes of corruption of the body of the Republic.

Resumen Este artículo aborda el concepto de corrupción en las sociedades de la Edad Moderna, preguntando acerca de su relevancia en este contexto histórico. A partir de una investigación sobre los significados de la palabra corrupción en los textos coetáneos, se propone reflexionar sobre las nociones que estructuraron el imaginario del mal gobierno. Considerada un vicio, la ambición desmedida de los gobernantes era objeto la condena en los textos políticos y morales de la época, siendo considerado una de las causas de la corrupción del cuerpo de la República.

Résumé Cet article traite de la notion de la corruption dans les sociétés de l’ère moderne, renseigner sur leur pertinence dans le contexte historique. De une enquête sur les significations du mot corruption dans les textes contemporaines, il est proposé de réfléchir sur les notions qui structurent le mauvais gouvernement de l’imaginaire. Considéré comme un vice, l’ambition excessive des dirigeants était l’objet de la condamnation dans les textes politiques et morales de l’époque, est considérée comme l’une des causes de la corruption du corps de la République.

Este artigo examina a construção da imagem de herói pacificador em torno de Antônio de Albuquerque, governador da capitania do Rio de Janeiro e depois da capitania de São Paulo e Minas do Ouro, considerado o responsável pela pacificação da Guerra dos Emboabas. Descrito por Cláudio Manuel da Costa como um herói dotado das virtudes da coragem e prudência, tal imagem se deslocaria depois para os estudos históricos, conformando as narrativas sobre a Guerra dos Emboabas, em particular, e a administração de Albuquerque, em geral.

This article examines the construction of the image of peacemaker hero Antônio de Albuquerque, governor of the captaincy of Rio de Janeiro and then the captaincy of São Paulo and Minas do Ouro, considered responsible for the pacification of the War of Emboabas. Described by Cláudio Manuel da Costa as a hero endowed with virtues like courage and wisdom, such image would then spread to historical studies, influencing the narratives on the War of Emboabas in particular, and the Albuquerque administration in general.

Cet article examine la construction d'une image de héros autour de Antônio de Albuquerque, gouverneur de la Capitainerie de Rio de Janeiro et plus tard, de la Capitainerie de São Paulo et Minas do Ouro, considéré le responsable de la pacification de la Guerre de Emboabas. Décrit par Cláudio Manuel da Costa comme un héros doté des vertus de courage et de sagesse, cette image s'est étendue plus tard aux études historiques, et ont influencé tout particulièrement les textes explicatifs sur la Guerre de Emboabas, et sur l'administration d'Albuquerque, en général.

Prostaglandins (PG's), produced from arachidonic acid metabolism, are potent mediators of inflammation. Nonsteroidal anti-inflammatory (NSAIDs) exert their effects by inhibition of prostaglandin endoperoxide synthase (PGHS) enzyme, which catalyses the first committed step in arachidonic acid metabolism. Two isoforms of PGHS are known: PGHS-1, constitutively expressed in most tissues, and is responsible for physiological production of PG's. The second isoform, PGHS-2, is induced by cytokines, mitogens and endotoxins in inflammatory cells, and appears to be responsible for the elevated production of PG's during inflammation. With the recent discovery of the inducible PGHS (PGHS-2), the medicinal chemist now possesses a novel target for designing therapeutic agents that could provide suitable anti-inflammatory activity without the ulcerogenic and renal side effects associated with currently available NSAIDs, all of which inhibit both PGHS-1 and PGHS-2.