ABSTRACT Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration. Results: The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers. Conclusions: The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile.

ABSTRACT This study aimed to assess the effect of rootstocks (IAC 572 and IAC 766) and potassium fertilization at different concentrations (0, 75, 150 and 300 kg·ha-1 K2O) on the phenology and thermal demand of the Niagara Rosada grapevine, and to evaluate the development of chemical traits during maturation stage. The length of the main phenological stages was recorded within two production seasons. Total thermal demand was calculated using the degree-day concept. The berries’ titratable acidity and soluble solids contents were determined during maturation. Results indicated that IAC 572 and IAC 766 rootstocks along with potassium fertilization had no influence on the phenological cycle or thermal demand of the Niagara Rosada grapevine. The production cycle lasted 144 to 148 days with thermal demands ranging from 1,465.2 to 1,615.1 degree-days. For better grape quality, i.e., with a balance between soluble solids and acidity levels, it is estimated that the grape harvest is carried out around 21 to 24 days after the veraison.

ABSTRACT Maize (Zea mays L.) is among the most cultivated crops in the world and can be affected by several diseases, especially those transmitted by seeds. The study of alternatives to fungicides used for seed treatment has a promising field in essential oils. Thus, this study determined the phytochemical profile of the ethanolic extract from Anadenanthera colubrina (Vell.) Brenan and to evaluate its antifungal activity on the sanitary and physiological quality of maize seeds. The seeds used were of the Jaboatão cultivar, which were submitted to the following treatments: control (untreated seeds), commercial fungicide (dicarboximide) and A. colubrina extract at 200, 400, 600, 800, and 1,000 ppm. The seeds were subjected to sanitary and germination tests in a completely randomized experimental design. Phytochemical prospecting of A. colubrina extract indicated the presence of alkaloids, tannins, flavonoids and saponins, as well as the major compounds lupeol, gallic acid, ferulic acid, catechin and quercetin. The A. colubrina extract reduced the incidence of Aspergillus spp., including Aspergillus niger, Alternaria spp., Curvularia spp. and Fusarium spp. at all concentrations. The highest concentrations (800 and 1,000 ppm) of the A. colubrina extract reduced the incidence of Penicillium spp. and yielded an effective control of Rhizoctonia spp. The extract of A. colubrina did not present phytotoxic effect, guaranteeing the viability and vigor of maize seeds.

This experimental in vitro study evaluated the influence of screw length on the mechanical properties of a locking reconstruction plate designed with locking rings inserted into plate holes. Synthetic bone cylinders with 10 mm fracture gap and seven-hole locking reconstruction plates were used. Two groups of bone-plate constructs were assembled: Group 1 – three monocortical screws on each fracture side, Group 2 - three bicortical screws on each fracture side. In each group nine bone-plate constructs were tested until failure, three each in bending, compression and torsion. In each group, 21 bone-plate constructs were tested for failure in fatigue testing, seven each for bending, compression and torsion. In all static testing no significant differences were found between G1 and G2, except ultimate moment in torsion test (G2>G1; P=0.008). Statistical analysis revealed significant differences between groups in axial compression fatigue testing (G1>G2; P<0.05) and four-point bending fatigue testing (G1<G2; P<0.05) in maximum load, minimum load, maximum moment, and minimum moment. In conclusion, screw length can affect the mechanical properties of locking reconstruction plate. Compared to bicortical screws, monocortical screws were less resistant to bending than axial compression. This must be considered when choosing implant, particularly in fractures under high axial loads.

Objective. Econometric analysis that seeks to measure the cost impact of a private insurer's own network upon outpatient care for its policyholders, own network refers to vertical integrated providers. The purpose is to assess whether greater use of its own network reduces the costs that the insurer incurred, according to what specialized literature suggests. Materials and methods. Study based on a multiple linear regression on data from a private insurer. The dependent variable is per capita cost of outpatient services. The explanatory variables are adherence to the own network and a number of variables to specify better the model. Results. With all other factors constant, in relation to covering the costs of outpatient care, it is noted that policyholders with high adhesion to their own network are less expensive than whose with low adhesion. Conclusions. The decision-making process about what services and what grade should be applied to each person by special conditions of the offer as the aggregation of human resources in own offices under formal rules has an impact on health care costs. Particular supply conditions cause variations in how resources are used.

Objetivo. Medir el impacto de la red propia (proveedores verticalmente integrados) de una aseguradora privada sobre los costos médicos ambulatorios de sus asegurados, a través de un análisis econométrico. Se busca verificar si un mayor uso de la red propia reduce los costos en los que la aseguradora incurre, de acuerdo con lo que sugiere la literatura especializada. Material y métodos. Estudio basado en una regresión lineal múltiple sobre los datos de una aseguradora privada. La variable dependiente es el costo per cápita de los servicios ambulatorios. Las variables explicativas son la adherencia a la red propia y una serie de variables para especificar mejor el modelo. Resultados. En relación con la cobertura de los costos de atención ambulatoria, si los demás factores se mantienen constantes, se observa que los asegurados con alta adherencia a la red propia presentan menores costos de atención que aquéllos con baja adherencia. Conclusión. El proceso decisorio sobre qué servicios y en qué grado debe ser aplicado a cada persona, por condiciones particulares de la oferta como el hecho de reunir recurso humano en sedes propias bajo reglas formales, presenta un impacto en los costos de atención en salud. Condiciones particulares de la oferta producen variaciones en la forma como son empleados los recursos.

Objective. Econometric analysis that seeks to measure the cost impact of a private insurer's own network upon outpatient care for its policyholders, own network refers to vertical integrated providers. The purpose is to assess whether greater use of its own network reduces the costs that the insurer incurred, according to what specialized literature suggests. Materials and methods. Study based on a multiple linear regression on data from a private insurer. The dependent variable is per capita cost of outpatient services. The explanatory variables are adherence to the own network and a number of variables to specify better the model. Results. With all other factors constant, in relation to covering the costs of outpatient care, it is noted that policyholders with high adhesion to their own network are less expensive than whose with low adhesion. Conclusions. The decision-making process about what services and what grade should be applied to each person by special conditions of the offer as the aggregation of human resources in own offices under formal rules has an impact on health care costs. Particular supply conditions cause variations in how resources are used.

Objetivo. Medir el impacto de la red propia (proveedores verticalmente integrados) de una aseguradora privada sobre los costos médicos ambulatorios de sus asegurados, a través de un análisis econométrico. Se busca verificar si un mayor uso de la red propia reduce los costos en los que la aseguradora incurre, de acuerdo con lo que sugiere la literatura especializada. Material y métodos. Estudio basado en una regresión lineal múltiple sobre los datos de una aseguradora privada. La variable dependiente es el costo per cápita de los servicios ambulatorios. Las variables explicativas son la adherencia a la red propia y una serie de variables para especificar mejor el modelo. Resultados. En relación con la cobertura de los costos de atención ambulatoria, si los demás factores se mantienen constantes, se observa que los asegurados con alta adherencia a la red propia presentan menores costos de atención que aquéllos con baja adherencia. Conclusión. El proceso decisorio sobre qué servicios y en qué grado debe ser aplicado a cada persona, por condiciones particulares de la oferta como el hecho de reunir recurso humano en sedes propias bajo reglas formales, presenta un impacto en los costos de atención en salud. Condiciones particulares de la oferta producen variaciones en la forma como son empleados los recursos.