Search | SciELO

ABSTRACT Objectives: Currently, not much is known about the interactions between voice and growth hormone (GH). We have described large kindred with isolated GH deficiency (IGHD) due to a GHRH receptor mutation, resulting in severe short stature and high-pitched voice. These IGHD individuals have little interest in GH treatment, as they consider themselves “short long-lived people”, rather than patients. Interestingly, they report normal general quality of life, but they rate their Voice-Related Quality of Life (V-RQOL) as low. Here, we assessed the social and auditory-perceptual impacts of artistic-intervention voice therapy with semioccluded vocal tract exercises (SOVTE) and choral singing, on their voices. Material and methods: Seventeen GH-naïve adult IGHD individuals were enrolled in a single-arm interventional pre-post study with 13 weekly sessions of choir singing over 90 days. Outcome measures were V-RQOL scores, self-assessment of voice, and auditory-perceptual analysis (GRBAS scale, G: grade of the severity of dysphonia; R: roughness; B: breathiness; A: asthenia; and S: strain). Results: Marked improvements in total (p = 0.0001), physical (p = 0.0002), and socioemotional (p = 0.0001) V-RQOL scores and in self-assessment of voice (p = 0.004) were found. The general grades of vocal deviation (p = 0.0001), roughness (p = 0.0001), breathiness (p = 0.0001) and strain (p = 0.0001) exhibited accentuated reductions. Conclusions: Voice therapy with semioccluded vocal tract exercises and choral training improved social impact and perceptual voice assessments in IGHD subjects and markedly improved their voice-related quality of life. This is particularly important in a setting where GH replacement therapy is not widely accepted.

https://doi.org/10.20945/2359-3997000000449

Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Andrade, Bruna M. R. de

; Valença, Eugenia H. O.

; Salvatori, Roberto

; Oliveira Neto, Luiz A.

; Souza, Anita H. O.

; Oliveira, Alaíde H. A.

; Oliveira, Mario C.P.

; Melo, Enaldo V.

; Carvalho, Susana de

; Sales, Neuza J

; Monteiro, Gisane C.

; Lima, José Marcel de

; Annunziato, Marcos Felipe Harder

; Mannis, Guilherme Daniel Breternitz

; Souza, Lucas E. de A.

; Goes, Yasmin D.

; Carvalho, Thayza S.

; Farias, Celiane de

; Santos, Michela P. dos

; Cardoso, Gabriela P. F.

; Sousa, Carla S. Pereira

; Santana, Julia Rodrigues

; Sales, Ester Almeida

; d’Avila, Jeferson Sampaio

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, N. ahead

Abstract: En | Text: En | PDF: En

https://doi.org/10.20945/2359-3997000000449

The occurrence of rhizobacteria from Paspalum genotypes and their effects on plant growth
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Amaral, Mayan Blanc

; Ribeiro, Thiago Gonçalves

; Alves, Gabriela Cavalcanti

; Coelho, Márcia Reed Rodrigues

; Matta, Frederico de Pina

; Baldani, José Ivo

; Baldani, Vera Lúcia Divan

Scientia Agricola

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, Volume 79 N. 2 elocation e20200240

Abstract: En | Text: En | PDF: En

ABSTRACT This work aimed to isolate and characterize plant growth promoting rhizobacteria (PGPR) from 10 Paspalum genotypes and evaluate the effect of their inoculation on P. regnellii, P. atratum, and P. malacophyllum genotypes. The bacterial population ranged from undetectable to 107 bacterial cells per gram of fresh matter in the Paspalum genotypes. Initially, we isolated 164 bacteria from rhizospheric soil and roots of the Paspalum genotypes using media N-free LG agar plate, semi-solid NFb, and LGI. The isolates were characterized genetically and physiologically. The sequencing of 16S rRNA showed the presence of many genera, and some are new in association with Paspalum. The most common was Bacillus followed by Rhizobium, Paraburkholderia, Enterobacter, Cupriavidus, Pseudomonas, Dyadobacter and Acinetobacter. Thirty-eight per cent of isolates produced siderophores, 25 % produced solubilized phosphate, and only 9 % produced indolic compounds. Three greenhouse experiments were performed in randomized blocks with six replicates using representative bacterial strains isolated from P. regnellii, P. malacophyllum and P. atratum cv. Pojuca. We also included strain Sp245 (Azospirillum baldaniorum), uninoculated control, and nitrogen control (150 kg N ha−1). There was an increase of up to 53 % in shoot dry matter in P. regnellii inoculated with strain Sp245 and the shoots accumulated more N. In contrast, only small effects were observed for the other Paspalum genotypes inoculated with PGPR from the host genotypes. This study shows a high diversity of diazotrophic rhizosphere bacteria and suggests no strain specificity between the bacterial isolates and the Paspalum genotypes.

https://doi.org/10.1590/1678-992x-2020-0240 330 downloads

A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Pecly, Inah Maria D.

; Azevedo, Rafael B.

; Muxfeldt, Elizabeth S.

; Botelho, Bruna G.

; Albuquerque, Gabriela G.

; Diniz, Pedro Henrique P.

; Silva, Rodrigo

; Rodrigues, Cibele I. S.

Brazilian Journal of Nephrology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2021, Volume 43 N. 4 Pages 551 - 571

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Acute kidney injury (AKI) in hospitalized patients with COVID-19 is associated with higher mortality and a worse prognosis. Nevertheless, most patients with COVID-19 have mild symptoms, and about 5% can develop more severe symptoms and involve hypovolemia and multiple organ dysfunction syndrome. In a pathophysiological perspective, severe SARS-CoV-2 infection is characterized by numerous dependent pathways triggered by hypercytokinemia, especially IL-6 and TNF-alpha, leading to systemic inflammation, hypercoagulability, and multiple organ dysfunction. Systemic endotheliitis and direct viral tropism to proximal renal tubular cells and podocytes are important pathophysiological mechanisms leading to kidney injury in patients with more critical infection, with a clinical presentation ranging from proteinuria and/or glomerular hematuria to fulminant AKI requiring renal replacement therapies. Glomerulonephritis, rhabdomyolysis, and nephrotoxic drugs are also associated with kidney damage in patients with COVID-19. Thus, AKI and proteinuria are independent risk factors for mortality in patients with SARS-CoV-2 infection. We provide a comprehensive review of the literature emphasizing the impact of acute kidney involvement in the evolutive prognosis and mortality of patients with COVID-19.

Resumo A lesão renal aguda (LRA) em pacientes hospitalizados com COVID-19 está associada a maior mortalidade e um pior prognóstico. No entanto, a maioria dos pacientes com COVID-19 tem sintomas leves e cerca de 5% podem desenvolver sintomas mais graves e envolver hipovolemia e síndrome de disfunção de múltiplos órgãos. Em uma perspectiva fisiopatológica, a infecção grave por SARS-CoV-2 é caracterizada por numerosas vias dependentes desencadeadas por hipercitocinemia, especialmente IL-6 e TNF-alfa, levando à inflamação sistêmica, hipercoagulabilidade e disfunção de múltiplos órgãos. A endotelite sistêmica e o tropismo viral direto às células tubulares proximais renais e podócitos são mecanismos fisiopatológicos importantes que levam à lesão renal em pacientes com infecção mais crítica, com uma apresentação clínica que varia de proteinúria e/ou hematúria glomerular a LRA fulminante, exigindo terapias renais substitutivas. Glomerulonefrite, rabdomiólise e drogas nefrotóxicas também estão associadas a danos renais em pacientes com COVID-19. Assim, a LRA e a proteinúria são fatores de risco independentes para mortalidade em pacientes com infecção por SARS-CoV-2. Fornecemos uma revisão abrangente da literatura, enfatizando o impacto do envolvimento renal agudo no prognóstico evolutivo e na mortalidade de pacientes com COVID-19.

https://doi.org/10.1590/2175-8239-jbn-2020-0204 3 downloads

COVID-19 and chronic kidney disease: a comprehensive review
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Pecly, Inah Maria D.

; Azevedo, Rafael B.

; Muxfeldt, Elizabeth S.

; Botelho, Bruna G.

; Albuquerque, Gabriela G.

; Diniz, Pedro Henrique P.

; Silva, Rodrigo

; Rodrigues, Cibele I. S.

Brazilian Journal of Nephrology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2021, Volume 43 N. 3 Pages 383 - 399

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Kidney impairment in hospitalized patients with SARS-CoV-2 infection is associated with increased in-hospital mortality and worse clinical evolution, raising concerns towards patients with chronic kidney disease (CKD). From a pathophysiological perspective, COVID-19 is characterized by an overproduction of inflammatory cytokines (IL-6, TNF-alpha), causing systemic inflammation and hypercoagulability, and multiple organ dysfunction syndrome. Emerging data postulate that CKD under conservative treatment or renal replacement therapy (RRT) is an important risk factor for disease severity and higher in-hospital mortality amongst patients with COVID-19. Regarding RAAS blockers therapy during the pandemic, the initial assumption of a potential increase and deleterious impact in infectivity, disease severity, and mortality was not evidenced in medical literature. Moreover, the challenge of implementing social distancing in patients requiring dialysis during the pandemic prompted national and international societies to publish recommendations regarding the adoption of safety measures to reduce transmission risk and optimize dialysis treatment during the COVID-19 pandemic. Current data convey that kidney transplant recipients are more vulnerable to more severe infection. Thus, we provide a comprehensive review of the clinical outcomes and prognosis of patients with CKD under conservative treatment and dialysis, and kidney transplant recipients and COVID-19 infection.

Resumo O comprometimento renal em pacientes hospitalizados com infecção por SARS-CoV-2 está associado ao aumento da mortalidade hospitalar e pior evolução clínica, levantando preocupações em relação a pacientes com doença renal crônica (DRC). De uma perspectiva fisiopatológica, a COVID-19 é caracterizada por uma superprodução de citocinas inflamatórias (IL-6, TNF-alfa), causando inflamação sistêmica e hipercoagulabilidade, e síndrome de disfunção de múltiplos órgãos. Dados emergentes postulam que a DRC sob tratamento conservador ou terapia renal substitutiva (TRS) é um fator de risco importante para a gravidade da doença e maior mortalidade hospitalar entre pacientes com COVID-19. Em relação à terapia com bloqueadores RAAS durante a pandemia, havia uma suposição inicial de que a classe pudesse causar um aumento potencial na infectividade, e impacto deletério na gravidade da doença e mortalidade, mas que não foi confirmada na literatura médica. Além disso, o desafio de implementar o distanciamento social em pacientes que necessitam de diálise durante a pandemia incentivou sociedades nacionais e internacionais a publicar recomendações sobre a adoção de medidas de segurança para reduzir o risco de transmissão e otimizar o tratamento de diálise durante a pandemia COVID-19. Os dados atuais mostram que os receptores de transplante renal são mais vulneráveis a infecções mais graves. Assim, fizemos uma revisão abrangente dos desfechos clínicos e prognóstico de pacientes com DRC sob tratamento conservador e diálise, e receptores de transplante renal e infecção por COVID-19.

https://doi.org/10.1590/2175-8239-jbn-2020-0203 1282 downloads

O USO DE SOFTWARES LIVRES EM AULA PRáTICA SOBRE FILTROS MOLECULARES DE BIODISPONIBILIDADE ORAL DE FáRMACOS
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Rodrigues, Gabriela dos Santos

; Avelino, Júnior A

; Siqueira, Ariane L. N.

; Ramos, Luciana F. P.

; Santos, Gabriela B. dos

Química Nova

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2021, Volume 44 N. 8 Pages 1036 - 1044

Abstract: Pt | Text: Pt | PDF: Pt

THE USE OF FREE SOFTWARES IN PRACTICAL CLASS ABOUT THE MOLECULAR FILTERS OF ORAL BIOAVAILABILITY OF DRUGS. The study of the physical chemical properties to predict the oral bioavailability of drugs is a widely tool used by researches on the Pharmaceutical and Medicinal Chemistry field. Even though it is a deeply studied subject, it is a complex task to teach to pharmacy students. Lipinski stablished that molecular weight, lipophilicity, hydrogen bond donors and acceptors are of great importance for oral bioavailability. In addition, Veber and Lovering added other properties, such as number of rotatable bonds, fraction of sp3 hybridized carbon and polar surface area that amplified the Lipinski Rule of 5. In this sense, the access to chemical databases and the comprehension of this information is an important task to undergraduate and graduate students. Thus, this work aims a new teaching methodology that values the critical interpretation of data and that favors the students comprehension beyond stablished rules.

https://doi.org/10.21577/0100-4042.20170739 61 downloads

A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Pecly, Inah Maria D.

; Azevedo, Rafael B.

; Muxfeldt, Elizabeth S.

; Botelho, Bruna G.

; Albuquerque, Gabriela G.

; Diniz, Pedro Henrique P.

; Silva, Rodrigo

; Rodrigues, Cibele I. S.

Brazilian Journal of Nephrology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, N. ahead

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/2175-8239-jbn-2020-0204

COVID-19 and chronic kidney disease: a comprehensive review
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Pecly, Inah Maria D.

; Azevedo, Rafael B.

; Muxfeldt, Elizabeth S.

; Botelho, Bruna G.

; Albuquerque, Gabriela G.

; Diniz, Pedro Henrique P.

; Silva, Rodrigo

; Rodrigues, Cibele I. S.

Brazilian Journal of Nephrology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, N. ahead

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/2175-8239-jbn-2020-0203

β-glucosidase from thermophilic fungus Thermoascus crustaceus: production and industrial potential
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

GARBIN, ANDREZA P.

; GARCIA, NAYARA F.L.

; CAVALHEIRO, GABRIELA F.

; SILVESTRE, MARIA ALICE

; RODRIGUES, ANDRÉ

; PAZ, MARCELO F. DA

; FONSECA, GUSTAVO G.

; LEITE, RODRIGO S.R.

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 93 N. 1 elocation e20191349

Abstract: En | Text: En | PDF: En

Abstract Microbial β-glucosidases can be used in several industrial processes, including production of biofuels, functional foods, juices, and beverages. In the present work, production of β-glucosidase by solid state cultivation of the fungus Thermoascus crustaceus in a low-cost cultivation medium (comprising agroindustrial residues) was evaluated. The highest production of β-glucosidase, about 415.1 U/g substrate (or 41.51 U/mL), was obtained by cultivating the fungus in wheat bran with 70% humidity, during 96 h at 40°C. The enzymatic activity was optimum at pH 4.5 and 65°C. β-Glucosidase maintained its catalytic activity when incubated at a pH range of 4.0-8.0 and temperature of 30-55°C. The enzyme was strongly inhibited by glucose; even when the substrate and glucose concentrations were equal, the inhibition was not reversed, suggesting a non-competitive inhibition. In the presence of up to 10% ethanol, β-glucosidase maintained its catalytic activity. In addition to β-glucosidase, the enzymatic extract showed activity of 36 U/g for endoglucanase, 256.2 U/g for xylanase, and 18.2 U/g for β-xylosidase. The results allow to conclude that the fungus T. crustaceus has considerable potential for production of β-glucosidase and xylanase when cultivated in agroindustrial residues, thereby reducing the cost of these biocatalysts.

https://doi.org/10.1590/0001-3765202120191349 566 downloads

10.

Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Banfi, Felipe Finger

; Krombauer, Gabriela Camila

; Fonseca, Amanda Luisa da

; Nunes, Renata Rachide

; Andrade, Silmara Nunes

; Rezende, Millena Alves de

; Chaves, Mariana Helena

; Monção Filho, Evaldo dos Santos

; Taranto, Alex Guterres

; Rodrigues, Domingos de Jesus

; Vieira Júnior, Gerardo Magela

; Castro, Whocely Victor de

; Varotti, Fernando de Pilla

; Sanchez, Bruno Antonio Marinho

Journal of Venomous Animals and Toxins including Tropical Diseases

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 27 elocation e20200073

Abstract: En | Text: En | PDF: En

Abstract Background: The resistance against antimalarial drugs represents a global challenge in the fight and control of malaria. The Brazilian biodiversity can be an important tool for research and development of new medicinal products. In this context, toxinology is a multidisciplinary approach on the development of new drugs, including the isolation, purification, and evaluation of the pharmacological activities of natural toxins. The present study aimed to evaluate the cytotoxicity, as well as the antimalarial activity in silico and in vitro of four compounds isolated from Rhinella marina venom as potential oral drug prototypes. Methods: Four compounds were challenged against 35 target proteins from P. falciparum and screened to evaluate their physicochemical properties using docking assay in Brazilian Malaria Molecular Targets (BraMMT) software and in silico assay in OCTOPUS® software. The in vitro antimalarial activity of the compounds against the 3D7 Plasmodium falciparum clones were assessed using the SYBR Green I based assay (IC50). For the cytotoxic tests, the LD50 was determined in human pulmonary fibroblast cell line using the [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Results: All compounds presented a ligand-receptor interaction with ten Plasmodium falciparum-related protein targets, as well as antimalarial activity against chloroquine resistant strain (IC50 = 3.44 μM to 19.11 μM). Three of them (dehydrobufotenine, marinobufagin, and bufalin) showed adequate conditions for oral drug prototypes, with satisfactory prediction of absorption, permeability, and absence of toxicity. In the cell viability assay, only dehydrobufotenin was selective for the parasite. Conclusions: Dehydrobufotenin revealed to be a potential oral drug prototype presenting adequate antimalarial activity and absence of cytotoxicity, therefore should be subjected to further studies.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0073 992 downloads

11.

Effect of chromium yeast supplementation on lipid profile of swine fat
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

ALENCAR, STEPHAN A.S.

; KIEFER, CHARLES

; NASCIMENTO, KARINA M.R.S

; VIANA, LUIZ HENRIQUE

; CORASSA, ANDERSON

; RODRIGUES, GABRIELA P.

; SILVA, CAMILLA M.

; CAVALHEIRO, LEANDRO F.

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 93 N. 3 elocation e20190619

Abstract: En | Text: En | PDF: En

Abstract This study was conducted to evaluate the period of chromium yeast supplementation on lipid profile of backfat and Longissimus lumborum muscle of barrows. It was evaluated carcass samples from forty barrows, genetically similar. Pigs diets were supplemented with 0.4 mg kg-1 of chromium yeast in four periods (0, 38, 62 and 94 days before slaughter). The experimental design was completely randomized with four treatments, ten replicates, and each experimental unit consisting of one animal. Lipid profiles of backfat and Longissimus lumborum muscle were analyzed by gas chromatography. The increase in the period of chromium yeast use had a quadratic effect (P<0.05) for stearic and oleic fatty acids, and total saturated, monounsaturated and unsaturated fatty acids in backfat. DH-γ-linolenic and arachidonic fatty acids reduced when the period of chromium yeast use increased. In the meat, there was a quadratic effect (P<0.05) only in the γ-linoleic fatty acid. The use of chromium yeast for different periods influences the lipid profile of the backfat and the Longissimus lumborum muscle, with less effect in the meat.

https://doi.org/10.1590/0001-3765202120190619 121 downloads

12.

Anti-inflammatory and Antioxidant Effects of the Microalga Pediastrum boryanum in Carrageenan-Induced Rat Paw Edema
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Silva, Marília Garcez Corrêa da

; Hort, Mariana Appel

; Hädrich, Gabriela

; Bosco, Lidiane Dal

; Vaz, Gustavo Richter

; Silva, Michelle Maidana Altenhofen da

; Tavella, Ronan Adler

; Badiale-Furlong, Eliana

; Silva Júnior, Flavio Manoel Rodrigues da

; Dora, Cristiana Lima

; Muccillo-Baisch, Ana Luiza

Brazilian Archives of Biology and Technology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 64 elocation e21200748

Abstract: En | Text: En | PDF: En

Abstract The potential use of microalgae in health has been the aim of different studies in the last years. This study investigated anti-inflammatory and antioxidant properties of three different extracts of green microalga Pediastrum boryanum in an acute inflammation model in rats. Rats were treated intraperitoneally with lyophilized biomass, the phenolic compounds and the extracellular extracts of P. boryanum before the induction of paw edema by the intraplantar injection of carrageenan. The edema and the levels of interleukin-1β and tumor necrosis factor-α were determined in the hind paw. Oxidative stress markers were analyzed in the liver and hepatic toxicity and genetic damage was evaluated in the blood. The results demonstrated that the three extracts of P. boryanum exhibited pronounced anti-oedematous property and decreased the levels of cytokines. The best results were provided by the phenolic compounds extract, that contains gallic, chlorogenic, protocathecuic and vanillic acid. A reduction in lipid peroxidation was observed after the treatment with lyophilized biomass and the extracellular extract improved the total antioxidant capacity of the liver. Moreover, no DNA damage and hepatic toxicity were observed after administration of P. boryanum extracts. In conclusion, these results suggest that P. boryanum can be an important source of anti-inflammatory compounds.

https://doi.org/10.1590/1678-4324-2021200748

13.

Refinement as ethics principle in animal research: Is it necessary to standardize the Environmental enrichment in laboratory animals?
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

FISCHER, MARTA L.

; RODRIGUES, GABRIELA S.

; AGUERO, WINDY P.

; ZOTZ, RAFAEL

; SIMÃO-SILVA, DAIANE P.

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 93 N. 1 elocation e20191526

Abstract: En | Text: En | PDF: En

Abstract The Environmental enrichment technique, although scientifically recognized for raising the level of animal welfare, has led to the questioning of its influence on the results of experimental research. Thus, the goal is to promote reflection about the need for standardization of these procedures. For that, documents and experimental analysis were done, in order to quantify and characterize the types of environmental enrichment used and to evaluate the effect of that in the social behavior of Rattus norvegicus. Data from the document review confirmed the hypothesis that the researchers have used a variety of methods, not demonstrating a concern for standardization and prior assessment of its effects on the search results. Demand was corroborated in the experimental study in which, although there was available a simple object acting as refuge promotes behavioral improvements, the presence of the co-specific, as well as characteristics of the micro and macro environment can compromise the homogeneity of the sample. The data from this study endorse the need for validation procedures of environmental enrichment for specific proposals, to investigative data comparison, are possible and contribute to the refinement of the search to reduce the number of animals targeted for this purpose.

https://doi.org/10.1590/0001-3765202120191526 691 downloads

14.

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 76 elocation e3511

Abstract: En | Text: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

15.

The genetic structure of Pristimantis latro. (Anura: Craugastoridae) mirrors traits of their life history
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santana-Cornélio, Gilcilene

; Araújo-de-Oliveira, Elciomar

; Magalhães-Xavier, Keila

; Barros-da-Silva, Gabriela Wemilly

; França, Isadora

; Ribeiro Rodrigues, Luis Reginaldo

; Hernández-Ruz, Emil José

Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2020, Volume 44 N. 172 Pages 729 - 739

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Una de las principales hipótesis para explicar el origen de la diversidad amazónica invoca el efecto de barrera de los ríos para explicar los patrones de diversidad. Esa hipótesis propone que algunos ríos pueden separar poblaciones continuas conduciendo a la diferenciación y la especiación. En ese sentido nos propusimos estudiar la estructura genética de Pristimantis latro, una especie recién descrita que habita una región bajo fuerte presión antrópica producto de la ganadería expansiva, la minería ilegal y la construcción de represas hidroeléctricas. El ADN se extrajo de 52 individuos de P. latro y se amplificó mediante reacción en cadena de la polimerasa (PCR) usando los marcadores mitocondriales 16S rRNA y COI. Para inferir el tiempo de divergencia entre las localidades de P. latro, construimos un árbol de especies e hicimos análisis de varianza molecular (AMOVA) para inferir la diferenciación genética entre y dentro de las poblaciones de P. latro. Encontramos que P. latro presenta una estructuración genética en las poblaciones de las márgenes derecha e izquierda del río Xingu y dentro de las regiones interfluviales deTapajós-Xingu y Xingu-Tocantins. Asimismo, el tiempo de divergencia entre las poblaciones de las márgenes derecha e izquierda del río Xingu aconteció hace aproximadamente 380.000 años. El patrón de estructura genética que se encontró se corresponde con el indicado en artículos recientes para el género Pristimantis, el cual revela que las especies sin renacuajos exhiben una estructura genética que responde a la hipótesis de los ríos como barreras.

Abstract One of the main hypotheses to explain the origin of Amazonian diversity is the barrier effect of the rivers known as the riverine-barrier hypothesis, which suggests that riverine barriers isolated once continuous populations leading to differentiation and speciation. In this context, we studied the genetic structure of Pristimantis latro, a newly described species that inhabits a region under marked anthropic pressure due to expansive livestock, illegal mining, and hydroelectric dam construction. The DNA was extracted from 52 P. latro individuals and then amplified via polymerase chain reaction (PCR) using the mitochondrial 16S rRNA and COI markers. To infer the time of divergence between the P. latro localities, we built a species tree and performed an analysis of molecular variance (AMOVA) to infer the genetic differentiation between and within the P. latro populations. We found that P. latro has a marked genetic structure in the populations of the right and left margins of the Xingu River and within the Tapajós-Xingu and Xingu-Tocantins interfluvial regions and that the time of divergence between the populations of the East and West banks of the Xingu River occurred approximately 380,000 years ago. This pattern of genetic structure corresponds to that reported in recent articles for the Pristimantis genus evidencing that species without tadpoles exhibit a genetic structure explained by the hypothesis of rivers as barriers.

https://doi.org/10.18257/raccefyn.956 41 downloads

Showing

itens per page

Page of 2 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »