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RESUMO Objetivo: Investigar os fatores sociodemográficos, maternos e gestacionais associados à capacidade antioxidante total da dieta em gestantes brasileiras. Métodos: Estudo transversal com 2.232 gestantes com 18 anos ou mais, no primeiro, segundo e terceiro trimestres de gestação de onze cidades das cinco regiões brasileiras. Foi aplicado um questionário semiestruturado para avaliação dos dados socioeconômicos, demográficos e de saúde, e o recordatório de 24h (R24h) para avaliação do consumo alimentar e análise da Capacidade Antioxidante Total da Dieta (CATd), estimada usando o método Ferric Reducing Antioxidant Power (FRAP). Resultados: A mediana de CATd foi de 5,32 mmol/dia. Aracaju (SE) apresentou a maior mediana de CATd (6,44 mmol/dia) e Palmas (TO) a menor (4,71 mmol/dia). As gestantes de 20 a 34 anos (OR 1,86; IC95% 1,26-2,76), 35 anos ou mais (OR 3,68; IC95% 2,21-6,14) e que estavam no segundo trimestre de gestação (OR 1,50; IC95%; 1,11-2,01) tiveram mais chances de estarem acima da mediana de CATd, enquanto as gestantes com maior escolaridade tinham 67% menos chance de estarem acima da mediana de CATd (OR 0,67; IC95% 0,48-0,92). Conclusão: O estudo demonstrou que há diferenças no consumo de antioxidantes em diferentes cidades do Brasil e que fatores associados, como idade, escolaridade e trimestre gestacional podem impactar na ingestão de alimentos ricos em antioxidantes. O perfil encontrado chama atenção para a importância de uma alimentação adequada e rica em antioxidantes durante o pré-natal.

ABSTRACT Objective: To investigate the sociodemographic, maternal, and gestational factors associated with the dietary total antioxidant capacity in pregnant Brazilian women. Methods: A cross-sectional study with 2,232 pregnant women aged 18 years old or older, in the first, second, and third trimesters of pregnancy, from eleven cities in the five Brazilian regions. A semi-structured questionnaire was applied to assess socioeconomic, demographic, and health data, and a 24-hour dietary recall (R24h) was used to assess food consumption and analyze the dietary total antioxidant capacity (DTAC), estimated using the ferric reducing antioxidant power (FRAP) method. Results: The median of DTAC was 5.32 mmol/day. Aracaju, Sergipe (SE) had the highest median of DTAC (6.44 mmol/day) and Palmas, Tocantins (TO) had the lowest (4.71 mmol/day). Pregnant women aged 20 to 34 years (OR 1.86; 95%CI 1.26-2.76), 35 years old or older (OR 3.68; 95%CI 2.21-6.14) and who were in the second trimester of pregnancy (OR 1.50; 95%CI 1.11-2.01) were more likely to be above the median DTAC. While pregnant women with higher education had a 67% lower chance of being above the median DTAC (OR 0.67; 95%CI 0.48-0.92). Conclusion: The study demonstrated that there are differences in antioxidant consumption in different cities in Brazil and that associated factors such as age, education, and gestational trimester can impact the intake of foods rich in antioxidants. The profile found draws attention to the importance of an adequate diet rich in antioxidants during prenatal care.

https://doi.org/10.1590/1980-549720250002

Factors associated with the dietary total antioxidant capacity of pregnant Brazilian women
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Carvalho, Roberta Rejane Santos de

; Viola, Poliana Cristina de Almeida Fonseca

; Crispim, Sandra Patrícia

; França, Ana Karina Teixeira da Cunha

; Navarro, Anderson Marliere

; Souza, Bruno Feres de

; Faria, Franciane Rocha de

; Sperandio, Naiara

; Pizato, Nathalia

; Macedo, Mariana de Souza

; Pereira, Renata Junqueira

; Franceschini, Sylvia do Carmo Castro

; Carvalho, Carolina Abreu de

; Navarro, Anderson Marliere

; Carvalho, Carolina Abreu de

; Silva, Danielle Góes da

; Faria, Franciane Rocha de

; Sperandio, Naiara

; Meléndez, Jorge Gustavo Velásquez

; Barbosa, Míriam do Carmo Rodrigues

; Pizato, Nathalia

; Macedo, Mariana de Souza

; Pereira, Renata Junqueira

; Crispim, Sandra Patrícia

; Priore, Silvia Eloiza

; Franceschini, Sylvia do Carmo Castro

Revista Brasileira de Epidemiologia

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2025, Volume 28 elocation e250002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720250002

Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis
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Baldi, Bruno Guedes

; Feitosa, Paulo Henrique Ramos

; Rubin, Adalberto Sperb

; Amaral, Alexandre Franco

; Freitas, Carolina Salim Gonçalves

; Costa, Cláudia Henrique da

; Mancuzo, Eliane Viana

; Nascimento, Ellen Caroline Toledo do

; Araujo, Mariana Sponholz

; Rocha, Marcelo Jorge Jacó

; Oliveira, Martina Rodrigues de

; Galvão, Tatiana Senna

; Torres, Pedro Paulo Teixeira e Silva

; Carvalho, Carlos Roberto Ribeiro

Jornal Brasileiro de Pneumologia

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2025, Volume 51 N. 1 elocation e20240378

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A linfangioleiomiomatose (LAM) é uma doença rara, caracterizada como uma neoplasia de baixo grau, com potencial metastatizante, que atinge principalmente mulheres em idade reprodutiva, em que se evidencia proliferação de células musculares lisas atípicas (células LAM) e formação de cistos pulmonares difusos. A LAM pode ocorrer na forma esporádica ou associada ao complexo de esclerose tuberosa. Vários progressos ocorreram no entendimento da fisiopatologia e no manejo da LAM nas últimas décadas, determinando melhora do seu prognóstico, incluindo: identificação dos principais aspectos genéticos e do papel da via da proteína alvo mecanístico da rapamicina (mTOR); relação com fatores hormonais, principalmente estrogênio; caracterização das manifestações pulmonares e extrapulmonares em exames de imagem; identificação e importância no diagnóstico do VEGF-D; abordagem diagnóstica sistematizada, muitas vezes sem necessidade de biópsia pulmonar; uso e indicações dos inibidores de mTOR, principalmente sirolimo, para quadros pulmonares e extrapulmonares; reabilitação pulmonar, abordagem de complicações, como pneumotórax e quilotórax; e papel e indicações do transplante pulmonar. Não havia até o momento uma publicação nacional com recomendações para a ampla abordagem da doença. Este documento se caracteriza como uma revisão não sistemática da literatura, realizada por 12 pneumologistas, um radiologista e um patologista, que visa atualizar os tópicos mais importantes relacionados principalmente ao diagnóstico, tratamento e seguimento da LAM, incluindo aspectos práticos e multidisciplinares do seu manejo.

ABSTRACT Lymphangioleiomyomatosis (LAM) is a rare disease, characterized as a low-grade neoplasm with metastatic potential that mainly affects women of reproductive age, in which there is proliferation of atypical smooth muscle cells (LAM cells) and formation of diffuse pulmonary cysts. It can occur in a sporadic form or in combination with tuberous sclerosis complex. In recent decades, a number of advances have been made in the understanding of the pathophysiology and management of LAM, leading to improvements in its prognosis: identification of the main genetic aspects and the role of the mechanistic target of rapamycin (mTOR) pathway; relationship with hormonal factors, mainly estrogen; characterization of pulmonary and extrapulmonary manifestations in imaging studies; identification and importance in the diagnosis of VEGF-D; a systematic diagnostic approach, often without the need for lung biopsy; use of and indications for the use of mTOR inhibitors, mainly sirolimus, for pulmonary and extrapulmonary manifestations; pulmonary rehabilitation and the management of complications such as pneumothorax and chylothorax; and the role of and indications for lung transplantation. To date, no Brazilian recommendations for a comprehensive approach to the disease have been published. This document is the result of a non-systematic review of the literature, carried out by 12 pulmonologists, a radiologist, and a pathologist, which aims to provide an update of the most important topics related to LAM, mainly to its diagnosis, treatment, and follow-up, including practical and multidisciplinary aspects of its management.

https://doi.org/10.36416/1806-3756/e20240378

Eradicating latent tuberculosis: use of interferon gamma release assay and isoniazid/rifapentine in people living with HIV/AIDS
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Monteiro, Mariana Amélia

; Apoliano, Carlos Fernando

; Martins, José Eduardo Rodrigues

; Sunada, Noemia Orii

; Folgosi, Víctor Ângelo

; Nascimento, Najara Ataíde de Lima

; Chimara, Erica

; Veiga, Ana Paula Rocha

; Pereira, Luisa de Oliveira

; Andrade, Luisa Caracik de Camargo

; Tiberto, Larissa

; Ferreira, Maurício Domingues

; Fonseca, Luiz Augusto Marcondes

; Duarte, Alberto José da Silva

; Arakaki-Sanchez, Denise

; Hong, Marisa Ailin

; Casseb, Jorge

Revista do Instituto de Medicina Tropical de São Paulo

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2025, Volume 67 elocation e14

Abstract: En | Text: En | PDF: En

ABSTRACT Tuberculosis (TB) is the most common comorbidity in people living with HIV/AIDS (PLWH), including those under antiretroviral treatment. PLWH are 28 times more likely to develop TB in Brazil, the leading cause of HIV-related deaths globally, with approximately 161,000 reported deaths worldwide in 2023. Early diagnosis of latent tuberculosis infection (LTBI) and prophylactic therapy can reduce TB cases, prevent disease progression, and decrease transmission in high-risk populations. This study assessed the prevalence of LTBI in PLWH using the interferon-gamma release assay (IGRA) and the impact of the 3HP regimen (isoniazid [INH]/rifapentine [RPT]) as prophylactic treatment. Blood samples from 335 PLWH (78% of the 427 in the cohort) were tested for IGRA; 50 PLWH (15%) tested positive and were treated with 3HP. Treatment included 900 mg of INH and 900 mg of RPT in 12 weekly doses according to the Brazilian health guidelines. No specific risk factors, including nadir CD4+T count, age, gender, or antiretroviral therapy (ART), were more frequently observed in the PLWH with LTBI compared to the PLWH without LTBI. All PLWH with LTBI received treatment and no cases of active TB were observed. Our findings highlight the need for wider LTBI screening and treatment among PLWH in the latent phase, emphasizing more stringent approaches for implementing 3HP prophylaxis.

https://doi.org/10.1590/s1678-9946202567014

Common mental disorders in Brazilian adolescents: association with school characteristics, consumption of ultra-processed foods and waist-to-height ratio
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Gratão, Lucia Helena Almeida

; Silva, Thales Philipe Rodrigues da

; Rocha, Luana Lara

; Jardim, Mariana Zogbi

; Oliveira, Tatiana Resende Prado Rangel de

; Cunha, Cristiane de Freitas

; Mendes, Larissa Loures

Cadernos de Saúde Pública

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2024, Volume 40 N. 4 elocation e00068423

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo: Metade de todos os problemas de saúde mental diagnosticados na idade adulta têm seu início antes ou durante a adolescência, especialmente os transtornos mentais comuns (TMC). Desta maneira, é importante estudar os fatores associados a estes transtornos. Este estudo objetiva investigar a associação entre características escolares, consumo de alimentos ultraprocessados e razão cintura/estatura com a presença de TMC em adolescentes brasileiros. Trata-se de um estudo transversal de base escolar que analisou dados de 71.553 adolescentes brasileiros de 12-17 anos. A prevalência de TMC nesses adolescentes foi de 17,1% (ponto de corte 5 para o Questionário de Saúde Geral - GHQ-12). As associações foram estimadas por meio de modelos logísticos multiníveis, tendo como variável dependente a presença de TMC. O modelo final, ajustado para variáveis individuais não modificáveis, variáveis individuais modificáveis e características familiares, identificou uma associação positiva entre dependência administrativa privada (OR = 1,1; IC95%: 1,07-1,14), presença de propaganda de alimentos ultraprocessados (OR = 1,13; IC95%: 1,09-1,17), segundo a quarto quartis de consumo de alimentos ultraprocessados e razão cintura/estatura (OR = 2,26; IC95%: 2,03-2,52). Este estudo demonstrou que a dependência administrativa privada da escola, a presença de propagandas de alimentos ultraprocessados, o consumo de alimentos ultraprocessados e o aumento da razão cintura/estatura são fatores de risco para TMC em adolescentes brasileiros.

Resumen: La mitad de todos los problemas de salud mental diagnosticados en la edad adulta empiezan antes o durante la adolescencia, sobre todo los trastornos mentales comunes (TMC). Así, es importante estudiar los factores asociados a estos trastornos. El objetivo de este estudio es investigar la asociación entre las características escolares, el consumo de alimentos ultraprocesados y la proporción cintura/estatura y la presencia de TMC en adolescentes brasileños. Se trata de un estudio transversal de base escolar que analizó datos de 71.553 adolescentes brasileños de 12 a 17 años. La prevalencia de TMC en estos adolescentes fue del 17,1% (punto de corte 5 para el Cuestionario General de Salud - GHQ-12). Se estimaron las asociaciones a través de modelos logísticos multinivel, con la presencia de TMC como variable dependiente. El modelo final, ajustado para variables individuales no modificables, variables individuales modificables y características familiares, identificó una asociación positiva entre la dependencia administrativa privada (OR = 1,10; IC95%: 1,07-1,14), la presencia de publicidad de alimentos ultraprocesados (OR = 1,13; IC95%: 1,09-1,17), segundo al cuarto cuartil de consumo de alimentos ultraprocesados y la proporción cintura/estatura (OR = 2,26; IC95%: 2,03-2,52). Este estudio demostró que la dependencia administrativa privada de la escuela, la presencia de publicidades de alimentos ultraprocesados, el consumo de alimentos ultraprocesados y el aumento de la proporción cintura/estatura son factores de riesgo para trastornos mentales comunes en adolescentes brasileños.

Abstract: Half of all mental health problems diagnosed in adulthood have their onset before or during adolescence, especially common mental disorders (CMD). Thus, it is relevant to study the factors associated with these disorders. This study aimed to investigate the association of school characteristics, consumption of ultra-processed foods, and waist-to-height ratio with the presence of CMD in Brazilian adolescents. This is a school-based, cross-sectional study that analyzed data from 71,553 Brazilian adolescents aged 12-17 years. The prevalence of CMD in these adolescents was 17.1% (cut-off point 5 for the General Health Questionnaire-12). Associations were estimated using multilevel logistic models, with the presence of CMD as the dependent variable. The final model, adjusted for non-modifiable individual variables, modifiable individual variables and family characteristics, identified a positive association between private-funded schools (OR = 1.10; 95%CI: 1.07-1.14), advertisements for ultra-processed foods (OR = 1.13; 95%CI: 1.09-1.17), the second to fourth quartiles of ultra-processed food intake and waist-to-height ratio (OR = 2.26; 95%CI: 2.03-2.52). This study demonstrated that the private-funded schools , the presence of ultra-processed food advertisements, the consumption of ultra-processed food, and an increased waist-to-height ratio are risk factors for CMD in Brazilian adolescents.

https://doi.org/10.1590/0102-311xen068423

Common mental disorders in Brazilian adolescents: association with school characteristics, consumption of ultra-processed foods and waist-to-height ratio
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Gratão, Lucia Helena Almeida

; Silva, Thales Philipe Rodrigues da

; Rocha, Luana Lara

; Jardim, Mariana Zogbi

; Oliveira, Tatiana Resende Prado Rangel de

; Cunha, Cristiane de Freitas

; Mendes, Larissa Loures

Cadernos de Saúde Pública

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2024, Volume 40 N. 4 elocation e00068423

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

https://doi.org/10.1590/0102-311xen068423

Incomplete recovery of the CD4+/CD8+ ratio is associated with the late introduction of antiretroviral therapy among people living with HIV infection
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Prates, Gabriela da Silva

; Monteiro, Mariana Amelia

; Oliveira, Éricka Constantinov

; Nascimento, Najara Ataide de Lima

; Veiga, Ana Paula Rocha

; Ferreira, Mauricio Domingues

; Polis, Thales José Bueno

; Caetano, Gabriela Prandi

; Soares, Beatriz Rodrigues Pellegrina

; Magri, Marcello Mihailenko Chaves

; Pereira, Luisa Oliveira

; Fonseca, Luiz Augusto Marcondes

; Alves, Wagner Silva

; Duarte, Alberto José da Silva

; Casseb, Jorge Simão do Rosário

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e7

Abstract: En | Text: En | PDF: En

ABSTRACT Despite being subject to lower AIDS-related mortality rates and having a higher life expectancy, patients with HIV are more prone to develop non-AIDS events. A low CD4+/CD8+ ratio during antiretroviral therapy identifies people with heightened immune senescence and increased risk of mortality. In clinical practice, finding determinants of a low CD4+/CD8+ ratio may be useful for identifying patients who require close monitoring due to an increased risk of comorbidities and death. We performed a prospective study on the evolution of the CD4+/CD8+ ratio in 60 patients infected with HIV (80% males), who were subjected to two different antiretroviral regimens: early and deferred therapy. The initial CD4+/CD8+ ratio was ≤1 for 70% of the patients in both groups. Older age, CD4+ cell count at inclusion, Nadir CD8+T-cell count, and Initial CD4+/CD8+ ratio ≤ 1 were risk factors for lack of ratio recovery. In the multivariate analysis, a CD4+/CD8+ ratio > 1 at the start of the treatment was found to be a determinant factor in maintaining a CD4+/CD8+ ratio > 1. The nadir CD4+T-cell count was lower in the deferred therapy group (p=0.004), and the last CD4+/CD8+ ratio ≤1 was not associated with comorbidities. Ratio recovery was not associated with the duration of HIV infection, time without therapy, or absence of AIDS incidence. A greater improvement was observed in patients treated early (p=0.003). In contrast, the slope of increase was slower in patients who deferred treatment. In conclusion, the increase in the CD4+/CD8+ ratio occurred mostly for patients undergoing early strategy treatment and its extension did not seem to be related to previous HIV-related factors.

https://doi.org/10.1590/s1678-9946202466007

Task force of the Brazilian Society of Otology — evaluation and management of peripheral facial palsy
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Pauna, Henrique Furlan

; Silva, Vagner Antonio Rodrigues

; Lavinsky, Joel

; Hyppolito, Miguel Angelo

; Vianna, Melissa Ferreira

; Gouveia, Mariana de Carvalho Leal

; Monsanto, Rafael da Costa

; Polanski, José Fernando

; Silva, Maurício Noschang Lopes da

; Soares, Vítor Yamashiro Rocha

; Sampaio, André Luiz Lopes

; Zanini, Raul Vitor Rossi

; Abrahão, Nicolau M.

; Guimarães, Guilherme Correa

; Chone, Carlos Takahiro

; Castilho, Arthur Menino

Brazilian Journal of Otorhinolaryngology

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2024, Volume 90 N. 3 elocation 101374

Abstract: En | Text: En | PDF: En

Abstract Objective To review key evidence-based recommendations for the diagnosis and treatment of peripheral facial palsy in children and adults. Methods Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on peripheral facial palsy were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions. Results The topics were divided into 2 main parts: (1) Evaluation and diagnosis of facial palsy: electrophysiologic tests, idiopathic facial palsy, Ramsay Hunt syndrome, traumatic peripheral facial palsy, recurrent peripheral facial palsy, facial nerve tumors, and peripheral facial palsy in children; and (2) Rehabilitation procedures: surgical decompression of the facial nerve, facial nerve grafting, surgical treatment of long-term peripheral facial palsy, and non-surgical rehabilitation of the facial nerve. Conclusions Peripheral facial palsy is a condition of diverse etiology. Treatment should be individualized according to the cause of facial nerve dysfunction, but the literature presents better evidence-based recommendations for systemic corticosteroid therapy.

https://doi.org/10.1016/j.bjorl.2023.101374

Impact of Telemedicine use on clinical care indicators of pediatric intensive care units: protocol for a cluster randomized clinical trial
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Silva, Mariana Motta Dias da

; Klever, Emanuele König

; Rocha, Jacqueline Castro da

; Silva, Gabriela de Oliveira Laguna

; Amorim, Jerusa da Rocha de

; Dode, Andressa Dutra

; Simionato, Bárbara Marina

; Cunha, Luciane Gomes da

; Zaupa, Ana Paula Berni

; Krauzer, João Ronaldo Mafalda

; Pires, Aristóteles de Almeida

; Cabral, Felipe Cezar

; Moreira, Tais de Campos

; Constant, Hilda Maria Rodrigues Moleda

Critical Care Science

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sep 2023, Volume 35 N. 3 Pages 266 - 272

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The objective of this study is to present the protocol of a cluster randomized clinical trial to be conducted through the TeleICU project - Qualification of Intensive Care by Telemedicine. The study will consist of a cluster randomized clinical trial, open label, in pediatric intensive care units, with an allocation ratio of 1:1, to compare the intervention group (support of Telemedicine for patients admitted to the pediatric intensive care unit) with a control group (pediatric intensive care unit usual care). The study proposed to select 16 pediatric intensive care units, including 100 participants per site, with a total of 1,600 participants. The intervention group will receive telerounds from Monday to Friday and will have specialists and continuing education activities available. The primary outcome measure will be the length of stay in the pediatric intensive care unit, defined as the difference between the date of discharge of the participant and the date of admission to the intensive care unit. The secondary outcomes will be mortality rate, invasive mechanical ventilation-free days, days using antibiotics, days using vasoactive drugs and days using sedoanalgesia. This study will be conducted in accordance with Resolution 466/12 of the National Health Council, with approval by the Research Ethics Committee of the institutions involved. The present study has the potential to reproduce studies on Telemedicine in intensive care and may make important contributions to care in intensive care units in Brazil and other settings. If Telemedicine shows positive clinical care results compared to conventional treatment, more pediatric patients may benefit. ClinicalTrials.gov registry: NCT05260710

RESUMO O objetivo deste estudo será apresentar o protocolo de um ensaio clínico randomizado em cluster a ser realizado por meio do projeto TeleUTI - Qualificação da Assistência em Terapia Intensiva por Telemedicina. O estudo consistirá em um ensaio clínico randomizado por cluster, open label, em unidades de terapia intensiva pediátricas, com proporção de alocação de 1:1, com o intuito de comparar o grupo de intervenção (apoio da telemedicina para os pacientes internados na unidade de terapia intensiva pediátrica) com um grupo controle (cuidados habituais da unidade de terapia intensiva pediátrica). O estudo se propõe a selecionar 16 unidades de terapia intensiva pediátricas, incluindo 100 participantes por local, com o total de 1.600 participantes. O grupo intervenção receberá telerounds de segunda-feira a sexta-feira e terá à disposição especialistas e atividades de educação continuada. O desfecho primário a ser avaliado será o tempo de permanência nas unidades de terapia intensiva pediátricas, definido pela diferença entre a data de alta do participante com a data de admissão na unidade de terapia intensiva. Os desfechos secundários serão: taxa de mortalidade; dias livres de ventilação mecânica, dias de uso de antibióticos, dias de uso de drogas vasoativas e dias de uso de sedoanalgesia. Este estudo será conduzido em conformidade com a resolução 466/12 do Conselho Nacional de Saúde, com aprovação pelo Comitê de Ética em Pesquisa das instituições hospitalares envolvidas. O trabalho tem o potencial de reproduzir estudos sobre Telemedicina em cuidados intensivos, podendo trazer contribuições importantes ao atendimento em unidades de terapia intensiva no Brasil e em outras realidades. Se a Telemedicina mostrar resultados clínicos assistenciais positivos em relação ao tratamento convencional, mais pacientes pediátricos poderão ser beneficiados. Registro ClinicalTrials.gov: NCT05260710

https://doi.org/10.5935/2965-2774.20230223-en

10.

Obstructive sleep apnea screening in different age groups: performance of the Berlin, STOP-Bang questionnaires and Epworth Sleepiness Scale
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Silva, Daniel Villela e

; Alves, Davi da Silveira Barroso

; Nóbrega, Mariana da Rocha Rodrigues

; Ribeiro, Felipe Braga Coelho Gomes

; Franco, Leandro Yukio Yatabe

; Silva, Isadora Rodrigues da

; Joffily, Lucia

; Rocha, Maira da

; Godoy, Paulo Henrique

Brazilian Journal of Otorhinolaryngology

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2023, Volume 89 N. 4 elocation 101283

Abstract: En | Text: En | PDF: En

Abstract Objective To evaluate the performance of the Berlin Questionnaire, the STOP-Bang Questionnaire, and the Epworth Sleepiness Scale in screening for the disease in adults of different age groups by comparing them with polysomnography. Methods Cross-sectional study with prospective patient allocation, in which individuals underwent a medical interview, completion of the three screening instruments, and polysomnography. Individuals were categorized into three age groups: 18-39, 40-59, and ≥60 years. The results of the screening instruments were compared to the diagnostic criteria of the International Classification of Sleep Disorders—third edition. Performance was assessed using 2 × 2 contingency tables, estimating sensitivity, specificity, predictive value, likelihood ratio, and accuracy. Receiver Operating Characteristic curves were also constructed and the area under the curve was estimated for each instrument by age group. Results We obtained a sample with 321 individuals suitable for analysis. The mean age was 50 years, with a predominance of females (56%). The prevalence of the disease in the overall sample was 79%, more prevalent in males in any age group and more frequent in the middle age group. The analyzes revealed that STOP-Bang performed better, both for the overall sample and for all age groups, followed by Berlin Questionnaire and Epworth Sleepiness Scale. Conclusion In an outpatient setting with individuals with characteristics similar to those in this study, it seems sensible to choose the STOP-Bang as a screening tool for the disease, regardless of age group. Level of evidence according the guide for authors: level 2.

https://doi.org/10.1016/j.bjorl.2023.101283

11.

Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak
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Gregianini, Tatiana Schäffer

; Salvato, Richard Steiner Barcellos, Regina Bones Godinho, Fernanda Marques Ruivo, Amanda Pellenz de Melo, Viviane Horn Schroder, Júlio Augusto Martiny, Fernanda Letícia Möllmann, Erica Bortoli Favreto, Cátia Baethgen, Ludmila Fiorenzano Ferreira, Vithoria Pompermaier de Lima, Lívia Eidt Piazza, Cláudia Fasolo Machado, Taís Raquel Marcon Becker, Irina Marieta Ramos, Raquel Rocha Frölich, Guilherme Carey Rossetti, Alana Fraga Almeida, Lucas da Cunha Rodrigues, Tahiana Machado Antunes Bragança, Isabella Tabelli Campos, Aline Alves Scarpellini Manzoni, Verônica Baú Machado, Lais Ceschini da Silva, Luisa Maria Inácio de Oliveira, André Luiz Sá Paiva, Marcelo Henrique Santos Nunes, Zenaida Marion Alves de Almeida, Paula Rodrigues Demoliner, Meriane Gularte, Juliana Schons da Silva, Mariana Soares Filippi, Micheli Pereira, Vyctoria Malayhka de Abreu Góes Spilki, Fernando Rosado da Veiga, Ana Beatriz Gorini Wallau, Gabriel Luz

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220259

Abstract: En | Text: En | PDF: En

BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.

https://doi.org/10.1590/0074-02760220259

12.

Atención de enfermería a mujeres en situación de violencia en Atención Primaria de Salud
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Santos do Vale, Hiugo

; Rodrigues da Rocha, Mariana

; Nunes da Conceição, Hayla

Revista Cubana de Enfermería

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mar 2022, Volume 38 N. 1 elocation e4067

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

RESUMEN Introducción: La violencia contra la mujer es un problema de salud pública y consiste en cualquier acto que resulte en daño físico, sexual o psicológico. Objetivo: Analizar la evidencia científica nacional e internacional sobre cuidados de enfermería a mujeres en situación de violencia en Atención Primaria de Salud. Métodos: Revisión integradora de la literatura, realizado de mayo a octubre de 2018, en seis pasos, los cuales fueron: delimitación del tema y pregunta orientadora, búsqueda bibliográfica, definición de información, evaluación estudios, interpretación de resultados y síntesis de conocimientos, mediante la búsqueda de artículos en las bases de datos Lilacs, BDENF y Medline; y en biblioteca digital SciELO. Se encontraron 48 artículos, después de filtrar los criterios de inclusión, texto completo disponible, en idioma portugués, inglés o español, quedaron siete estudios. Los datos fueron procesados en el software IRAMUTEC y analizados por clasificación jerárquica descendente, basada en el dendograma. Fueron presentados en 5 clases, a saber: 1- Asistencia a mujeres víctimas de violencia intrafamiliar. 2- Dificultad de los profesionales para identificar e intervenir en casos de violencia contra la mujer. 3- Dispositivos utilizados para brindar atención integral a mujeres en situación de violencia. 4- El miedo como factor de perpetuación de la violencia contra la mujer. 5- Asistencia multiprofesional a víctimas de violencia intrafamiliar. Conclusión: Las enfermeras tienen un papel fundamental en la identificación e intervención en los casos de violencia contra la mujer, a través de una atención integral, humanizada y de calidad.

RESUMO Introdução: A violência contra a mulher é um problema de saúde pública e consiste em qualquer ato que resulte em dano físico, sexual ou psicológico. Objetivo: Analisar as evidências científicas nacionais e internacionais sobre a assistência de enfermagem à mulher em situação de violência na Atenção Básica à Saúde. Métodos: Revisão integrativa da literatura, realizada de maio a outubro de 2018, em seis etapas, quais sejam, delimitação do tema e questão norteadora, busca bibliográfica, definição das informações, avaliação dos estudos, interpretação dos resultados e síntese do conhecimento, por meio busca de artigos nas bases de dados Lilacs, BDENF e Medline; e na biblioteca digital SciELO. Foram encontrados 48 artigos, filtrados os critérios de inclusão, texto completo disponível, nos idiomas português, inglês ou espanhol, restando sete estudos. Os dados foram processados no software IRAMUTEC e analisados por meio de classificação hierárquica descendente, com base no dendrograma. Foram apresentados em 5 turmas, a saber: 1- Atendimento a mulheres vítimas de violência doméstica. 2- Dificuldade dos profissionais em identificar e intervir nos casos de Violência contra a Mulher. 3- Dispositivos para atendimento integral à mulher em situação de violência. 4- O medo como fator de perpetuação da violência contra a mulher. 5- Atendimento multiprofissional às vítimas de violência doméstica. Conclusão: O enfermeiro tem papel fundamental na identificação e intervenção nos casos de violência contra a mulher, por meio de uma assistência integral, humanizada e de qualidade

ABSTRACT Introduction: Violence against women is a public health concern, manifested through any act resulting in physical, sexual or psychological harm. Objective: To analyze the national and international scientific evidence on nursing care for women in a situation of violence at the level of primary healthcare. Methods: An integrative literature review was carried out from May to October 2018, taking into account six steps: delimitation of topic and guiding question, literature search, definition of information, assessment of studies, interpretation of results, and synthesis of knowledge, by searching articles in the Lilacs, BDENF and Medline databases, as well as in the digital library of SciELO. Forty-eight articles were found; after filtering the inclusion criteria (full texts written in Portuguese, English or Spanish), seven studies remained. The data were processed in the IRAMUTEC software and analyzed by descending hierarchical classification, based on the dendogram. They were presented in five classes: support to women victims of family violence, professionals’ difficulties to identify and intervene in cases of violence against women, devices used to provide comprehensive care to women in a situation of violence, fear as a factor in perpetuating violence against women, and multiprofessional assistance to victims of family violence. Conclusion: Nurses have a fundamental role for the identification and intervention in cases of violence against women through comprehensive, humanized and quality care.

13.

Technical performance of a lateral flow immunoassay for detection of anti-SARS-CoV-2 IgG in the outpatient follow-up of non-severe cases and at different times after vaccination: comparison with enzyme and chemiluminescent immunoassays
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Barreira, Gabriel Acca

; Santos, Emilly Henrique dos

; Pereira, Maria Fernanda Bádue

; Rodrigues, Karen Alessandra

; Rocha, Mussya Cisotto

; Kanunfre, Kelly Aparecida

; Marques, Heloisa Helena de Sousa

; Okay, Thelma Suely

; Eisencraft, Adriana Pasmanik Rossi Junior, Alfio Fante, Alice Lima Cora, Aline Pivetta Costa Reis, Amelia Gorete A. de Ferrer, Ana Paula Scoleze Andrade, Anarella Penha Meirelles de Watanabe, Andreia Gonçalves, Angelina Maria Freire Waetge, Aurora Rosaria Pagliara Silva, Camila Altenfelder Ceneviva, Carina Lazari, Carolina dos Santos Abellan, Deipara Monteiro Sabino, Ester Cerdeira Bianchini, Fabíola Roberta Marim Alcantara, Flávio Ferraz de Paes Ramos, Gabriel Frizzo Leal, Gabriela Nunes Rodriguez, Isadora Souza Pinho, João Renato Rebello Carneiro, Jorge David Avaizoglou Paz, Jose Albino Ferreira, Juliana Carvalho Ferranti, Juliana Ferreira Ferreira, Juliana de Oliveira Achili Framil, Juliana Valéria de Souza Silva, Katia Regina da Bastos, Karina Lucio de Medeiros Galleti, Karine Vusberg Cristofani, Lilian Maria Suzuki, Lisa Campos, Lucia Maria Arruda Perondi, Maria Beatriz de Moliterno Diniz, Maria de Fatima Rodrigues Fonseca, Maria Fernanda Mota Cordon, Mariana Nutti de Almeida Pissolato, Mariana Peres, Marina Silva Garanito, Marlene Pereira Imamura, Marta Dorna, Mayra de Barros Luglio, Michele Aikawa, Nadia Emi Degaspare, Natalia Viu Sakita, Neusa Keico Udsen, Nicole Lee Scudeller, Paula Gobi Gaiolla, Paula Vieira de Vincenzi Severini, Rafael da Silva Giannasi Rodrigues, Regina Maria Toma, Ricardo Katsuya Paula, Ricardo Iunis Citrangulo de Palmeira, Patricia Forsait, Silvana Farhat, Sylvia Costa Lima Sakano, Tânia Miyuki Shimoda Koch, Vera Hermina Kalika Cobello Junior, Vilson

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e49

Abstract: En | Text: En | PDF: En

ABSTRACT This study assessed the technical performance of a rapid lateral flow immunochromatographic assay (LFIA) for the detection of anti-SARS-CoV-2 IgG and compared LFIA results with chemiluminescent immunoassay (CLIA) results and an in-house enzyme immunoassay (EIA). To this end, a total of 216 whole blood or serum samples from three groups were analyzed: the first group was composed of 68 true negative cases corresponding to blood bank donors, healthy young volunteers, and eight pediatric patients diagnosed with other coronavirus infections. The serum samples from these participants were obtained and stored in a pre-COVID-19 period, thus they were not expected to have COVID-19. In the second group of true positive cases, we chose to replace natural cases of COVID-19 by 96 participants who were expected to have produced anti-SARS-CoV-2 IgG antibodies 30-60 days after the vaccine booster dose. The serum samples were collected on the same day that LFIA were tested either by EIA or CLIA. The third study group was composed of 52 participants (12 adults and 40 children) who did or did not have anti-SARS-CoV-2 IgG antibodies due to specific clinical scenarios. The 12 adults had been vaccinated more than seven months before LFIA testing, and the 40 children had non-severe COVID-19 diagnosed using RT-PCR during the acute phase of infection. They were referred for outpatient follow-up and during this period the serum samples were collected and tested by CLIA and LFIA. All tests were performed by the same healthcare operator and there was no variation of LFIA results when tests were performed on finger prick whole blood or serum samples, so that results were grouped for analysis. LFIA’s sensitivity in detecting anti-SARS-CoV-2 IgG antibodies was 90%, specificity 97.6%, efficiency 93%, PPV 98.3%, NPV 86.6%, and likelihood ratio for a positive or a negative result were 37.5 and 0.01 respectively. There was a good agreement (Kappa index of 0.677) between LFIA results and serological (EIA or CLIA) results. In conclusion, LFIA analyzed in this study showed a good technical performance and agreement with reference serological assays (EIA or CLIA), therefore it can be recommended for use in the outpatient follow-up of non-severe cases of COVID-19 and to assess anti-SARS-CoV-2 IgG antibody production induced by vaccination and the antibodies decrease over time. However, LFIAs should be confirmed by using reference serological assays whenever possible.

https://doi.org/10.1590/s1678-9946202264049

14.

Instrumentos de evaluación del conocimiento sobre enfermedades cardiovasculares: revisión integradora
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Rodrigues da Rocha, Mariana Nunes da Conceição, Hayla Santos do Vale, Hiugo Pacheco Rodrigues, Malvina Thais Medeiros Mascarenhas, Márcio Dênis Vilarouca da Silva, Ana Roberta

Enfermería Global

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2021, Volume 20 N. 64 Pages 629 - 672

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT: Objective: To identify and describe the instruments for assessing knowledge about risk factors and prevention of cardiovascular diseases. Methods: This is an integrative literature review conducted in the months of May 2019 and June 2020, through searches at the LILACS, MEDLINE and SciELo databases, using the descriptors knowledge, cardiovascular diseases, risk factors, prevention of diseases and validation studies. The sample included instrument validation studies, published in the years 2005 through 2019, available in Portuguese, English and Spanish, which answered the guiding question. Results: 12 instruments were found. Most were questionnaires and addressed cardiovascular risk factors and lifestyle, directed to people diagnosed with a Cardiovascular Disease (CVD) and to healthy individuals. Nine instruments were developed and validated in terms of content and construct. Ten studies developed and validated questionnaires and the other studies built and validated scales. The most evaluated CVD was coronary artery disease. Conclusion: Instruments are indispensable strategies for measuring the level of knowledge, contributing to supporting the clinical treatment of patients, planning and evaluating educational health programs and practices.

RESUMEN: Objetivo: Identificar y describir los instrumentos para evaluar el conocimiento sobre factores de riesgo y prevención de enfermedades cardiovasculares. Métodos: Se trata de una revisión integradora de la literatura realizada en los meses de mayo de 2019 y junio de 2020, mediante búsquedas en las bases de datos LILACS, MEDLINE y SciELo, utilizando los descriptores conocimiento, enfermedades cardiovasculares, factores de riesgo, prevención de enfermedades y estudios de validación. Se incluyeron estudios de validación de instrumentos, publicados en los años 2005 a 2019, disponible en portugués, inglés y españo, y para responder a la pregunta orientadora. Resultados: Se encontraron 12 instrumentos. La mayoría eran cuestionarios y abordaban factores de riesgo cardiovascular y estilo de vida dirigidos a personas diagnosticadas con una enfermedad cardiovascular (ECV) y a individuos sanos. Se desarrollaron y validaron nueve instrumentos en términos de contenido y construcción. Diez estudios desarrollaron y validaron cuestionarios y los otros estudios construyeron y validaron escalas. La ECV más evaluada fue la enfermedad arterial coronaria. Conclusión: Los instrumentos son estrategias indispensables para medir el nivel de conocimiento, contribuir a apoyar el tratamiento clínico de los pacientes, planificar y evaluar programas y prácticas educativas en salud.

RESUMO: Objetivo: Identificar e descrever os instrumentos de avaliação do conhecimento sobre fatores de risco e prevenção de doenças cardiovasculares. Métodos: Trata-se de uma revisão integrativa da literatura realizada nos meses de maio de 2019 e junho de 2020, por meio de buscas nas bases de dados LILACS, MEDLINE e SciELo, utilizando os descritores knowledge, cardiovascular diseases, risk factors, prevention of diseases e validation studies. Foram incluídos estudos de validação de instrumentos, publicados nos anos de 2005 a 2019; disponíveis em português, inglês e espanhol; e que respondessem à questão norteadora. Resultados: Foram encontrados 12 instrumentos. A maioria eram questionários e abordaram fatores de risco cardiovasculares e estilo de vida sendo direcionados a pessoas com diagnóstico de alguma Doença Cardiovascular (DCV) e a indivíduos sadios. Nove instrumentos foram desenvolvidos e validados quanto ao conteúdo e construto. Dez estudos desenvolveram e validaram questionários e os demais estudos construiram e validaram escalas. A DCV mais avaliada foi a doença arterial coronariana. Conclusão: Os instrumentos são estratégias indispensáveis para mensurar o nível de conhecimento, contribuir no apoio ao tratamento clínico dos pacientes, planejar e avaliar os programas e práticas educacionais em saúde.

https://doi.org/10.6018/eglobal.442251

15.

Prevalência e fatores associados ao excesso de peso em adultos nas capitais e no Distrito Federal, Brasil, 2019
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Sousa, Alana Paulina de Moura

; Pereira, Izabela Cristina

; Araujo, Laécio de Lima

; Rocha, Mariana Rodrigues da

; Bandeira, Hilda Maria Martins

; Lima, Luisa Helena de Oliveira

Epidemiologia e Serviços de Saúde

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2021, Volume 30 N. 3 elocation e2020838

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo Objetivo Analisar a prevalência e fatores associados ao excesso de peso nas capitais e no Distrito Federal, Brasil, 2019. Métodos Se Estudo transversal, com dados do inquérito Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico, 2019. Calculou-se a prevalência de excesso de peso e sua associação com características sociodemográficas, comportamentais e situação de saúde, estratificada segundo sexo. Resultados A prevalência de excesso de peso foi de 55,9% (IC95% 54,9;56,9). Nos homens, ela se associou à idade de 35-44 anos (RP=1,87 - IC95% 1,65;2,12), consumo de álcool (RP=1,09 - IC95% 1,03;1,15) e hipertensão (RP=1,24 - IC95% 1,17;1,31), enquanto nas mulheres associou-se à idade de 45-54 anos (RP=2,03 - IC95% 1,77;2,32), hábito de assistir à televisão 3h/dia (RP=1,09 - IC95% 1,04;1,15) e estado de saúde ruim/muito ruim (RP=1,31 - IC95% 1,20;1,43). Conclusão Observou-se excesso de peso em mais da metade da amostra, associado a hipertensão, diabetes mellitus e consumo de álcool, em ambos os sexos.

Resumen Objetivo Se Analizar la prevalencia y factores asociados al sobrepeso en las capitales brasileñas y el Distrito Federal, Brasil, 2019. Métodos Se Estudio transversal, con datos de la Vigilancia de Factores de Riesgo y Protección de Enfermedades Crónicas por Encuesta Telefónica, 2019. Se calculó la prevalencia de sobrepeso y su asociación con características sociodemográficas, conductuales y estado de salud, estratificada por sexo. Resultados Se La prevalencia de sobrepeso fue del 55,9% (IC95% 54,9; 56,9), asociada en hombres con la edad de 35-44 años (RP=1,87 - IC95% 1,65;2,12), consumo de alcohol (RP=1,09 - IC95% 1,03;1,15) e hipertensión (RP=1,24 - IC95% 1,17;1,31); y en mujeres, asociada a la edad 45-54 años (RP=2,03 - IC95% 1,77;2,32), hábito de ver televisión durante 3h/día (RP=1,09 - IC95% 1,04;1,15) y mal/muy mal estado de salud (RP=1,31 - IC95% 1,20;1,43). Conclusión Se Se observó sobrepeso en más de la mitad de la muestra, asociado hipertensión, diabetes mellitus y consumo de alcohol, en ambos sexos.

Abstract Objective Se To analyze the prevalence and factors associated with overweight in Brazilian capitals and the Federal District, Brazil, 2019. Methods Se Cross-sectional study, with data from the Surveillance of risk and protective factors for chronic diseases by telephone survey, 2019. Prevalence was calculated overweight and association with sociodemographic and behavioral characteristics and health status, stratified according to sex. Results Se The prevalence of overweight was 55.9% (95%CI 54.9;56.9), associated in men with age of 35-44 years (PR=1.87 - 95%CI 1.65;2.12), alcohol consumption (PR=1.09 - 95%CI 1.03;1.15), and hypertension (PR=1.24 - 95%CI 1.17;1.31); and in women, associated to age 45-54 years (PR=2.03 - 95%CI 1.77;2.32), habit of watching television for 3h/day (PR=1.09 - 95%CI 1.04;1.15), and poor/very poor health status (PR=1.31 - 95%CI 1.20;1.43). Conclusion Se Overweight was observed in more than half of the sample, associated with hypertension, diabetes mellitus and alcohol consumption, in both sexes.

https://doi.org/10.1590/s1679-49742021000300014

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