ABSTRACT Introduction: To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients. Method: The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on patients who used ASP from 2010 to 2017 was collected. Allergic reactions were identified in electronic medical records. Results: Among the 98 patients included in the study, 16 (16.3 %) experienced an allergic reaction to native l-asparaginase (L-ASP). Of the 22 patients (22.4 %) that received only intravenous (IV) administration of l-ASP, 10 (62.5 %) had allergic reactions, while 48 patients (49 %) received intramuscular (IM) administration and 28 (28.6 %) received IV and IM administrations. The occurrence of allergic reactions differed between the groups (p < 0.001), and IV administration was associated with allergic reactions. Association was also observed between the severity of the reaction and the route of administration, with the IM route associated with grade 2 and IV route associated with grade 3. Occurrence of allergic reactions was higher when the commercial formulation of l-ASP, Leuginase®, was used (p = 0.0009 in the analysis per patient and p = 0.0003 in the analysis per administration). Conclusions: The IV administration and commercial Leuginase® presentation were associated with more allergic reactions in the study population, which corroborates the findings in the literature. The IV route was also associated with higher severity of reactions in the present study.

O uso de psicofármacos está aumentando e no Brasil há poucos estudos investigando seu emprego pela população e na Atenção Primária à Saúde (APS). Este estudo buscou verificar a prevalência e o padrão de consumo por usuários de uma Unidade de Saúde da Família de Porto Alegre através de um delinemeanto observacional, descritivo, retrospectivo e de corte transversal. A amostra foi composta por usuários que retiraram receitas de medicamentos controlados e os dados coletados a partir do prontuário. Foram incluídos 329 usuários, com prevalência de utilização de psicofármacos de 7,30%, média de idade de 53,14 (DP = 18,58) anos e 72% de indivíduos do sexo feminino. A média de medicamentos e psicofármacos prescritos por usuário foi de 3,56 (DP = 2,36) e 1,66 (DP = 0,90), respectivamente. A classe mais utilizada foi a de antidepressivos, seguida de antiepiléticos, ansiolíticos e antipsicóticos. Faz-se necessário elaborar estratégias para melhorar o acesso, tratamento dos usuários e uso racional de psicofármacos, incluindo a revisão das listas de medicamentos essenciais e a capacitação dos profissionais da APS.

The use of psychotropic drugs is on the increase, and there are few studies in Brazil investigating their use in the population and in Primary Health Care (PHC). This study aimed to determine the prevalence and patterns of psychotropic drug use by patients of a Family Health Unit in Porto Alegre, through an observational, descriptive, retrospective and cross-sectional study. The sample consisted of patients who received prescriptions for controlled psychotropic drugs and the data collected from medical records. The study included 329 patients, with prevalence of the use of psychotropic drugs of 7.30%, mean age of 53.14 (SD = 18.58) years and 72% female. The average number of prescribed drugs and psychotropic drugs per user was 3.56 (SD = 2.36) and 1.66 (SD = 0.90), respectively. The most widely used class was antidepressants, followed by antiepileptics, anxiolytics and antipsychotics. It is necessary to develop strategies to improve access, treatment of patients and rational use of psychotropic drugs, including the revision of lists of essential drugs and training of professionals in PHC.

O uso de psicofármacos está aumentando e no Brasil há poucos estudos investigando seu emprego pela população e na Atenção Primária à Saúde (APS). Este estudo buscou verificar a prevalência e o padrão de consumo por usuários de uma Unidade de Saúde da Família de Porto Alegre através de um delinemeanto observacional, descritivo, retrospectivo e de corte transversal. A amostra foi composta por usuários que retiraram receitas de medicamentos controlados e os dados coletados a partir do prontuário. Foram incluídos 329 usuários, com prevalência de utilização de psicofármacos de 7,30%, média de idade de 53,14 (DP = 18,58) anos e 72% de indivíduos do sexo feminino. A média de medicamentos e psicofármacos prescritos por usuário foi de 3,56 (DP = 2,36) e 1,66 (DP = 0,90), respectivamente. A classe mais utilizada foi a de antidepressivos, seguida de antiepiléticos, ansiolíticos e antipsicóticos. Faz-se necessário elaborar estratégias para melhorar o acesso, tratamento dos usuários e uso racional de psicofármacos, incluindo a revisão das listas de medicamentos essenciais e a capacitação dos profissionais da APS.

The use of psychotropic drugs is on the increase, and there are few studies in Brazil investigating their use in the population and in Primary Health Care (PHC). This study aimed to determine the prevalence and patterns of psychotropic drug use by patients of a Family Health Unit in Porto Alegre, through an observational, descriptive, retrospective and cross-sectional study. The sample consisted of patients who received prescriptions for controlled psychotropic drugs and the data collected from medical records. The study included 329 patients, with prevalence of the use of psychotropic drugs of 7.30%, mean age of 53.14 (SD = 18.58) years and 72% female. The average number of prescribed drugs and psychotropic drugs per user was 3.56 (SD = 2.36) and 1.66 (SD = 0.90), respectively. The most widely used class was antidepressants, followed by antiepileptics, anxiolytics and antipsychotics. It is necessary to develop strategies to improve access, treatment of patients and rational use of psychotropic drugs, including the revision of lists of essential drugs and training of professionals in PHC.

A epidermólise bolhosa hereditária (EBH) compreende um grupo heterogêneo de desordens genéticas que têm em comum a fragilidade cutânea e, em alguns casos mucosa, predispondo ao desenvolvimento de bolhas e/ou erosões após fricção ou trauma mínimo. Crianças com história recorrente deste tipo de lesão ou neonatos que as apresentem na ausência de outra explicação plausível devem ser investigados. O diagnóstico deve se basear em achados clínicos e histopatológicos. Até o presente momento, o manejo da EBH consiste basicamente em evitar os traumas desencadeadores das lesões, bem como evitar a infecção e facilitar a cicatrização das feridas com o uso sistemático de curativos.

Inherited epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders that present with skin and, in some cases, mucosal fragility, predisposing patients to the development of blisters and/or erosions after minimal trauma or friction. Children with a recurrent history of these kinds of lesions or neonates that present them in the absence of another reasonable explanation should be investigated. Diagnosis must be based on clinical and histopathological findings. To date, management of inherited EB basically consists in avoiding traumas that trigger lesions, as well as preventing infection and facilitating healing of the wounds with the systematic use of bandages.