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ABSTRACT The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed. This guidance has been instrumental in promoting transparent evaluation of new interventions. More recently, there has been a growing recognition that interventions involving artificial intelligence (AI) need to undergo rigorous, prospective evaluation to demonstrate their impact on health outcomes. The SPIRIT-AI (Standard Protocol Items: Recommendations for Interventional Trials–Artificial Intelligence) extension is a new reporting guideline for clinical trial protocols evaluating interventions with an AI component. It was developed in parallel with its companion statement for trial reports: CONSORT-AI (Consolidated Standards of Reporting Trials–Artificial Intelligence). Both guidelines were developed through a staged consensus process involving literature review and expert consultation to generate 26 candidate items, which were consulted upon by an international multi-stakeholder group in a two-stage Delphi survey (103 stakeholders), agreed upon in a consensus meeting (31 stakeholders) and refined through a checklist pilot (34 participants). The SPIRIT-AI extension includes 15 new items that were considered sufficiently important for clinical trial protocols of AI interventions. These new items should be routinely reported in addition to the core SPIRIT 2013 items. SPIRIT-AI recommends that investigators provide clear descriptions of the AI intervention, including instructions and skills required for use, the setting in which the AI intervention will be integrated, considerations for the handling of input and output data, the human–AI interaction and analysis of error cases. SPIRIT-AI will help promote transparency and completeness for clinical trial protocols for AI interventions. Its use will assist editors and peer reviewers, as well as the general readership, to understand, interpret and critically appraise the design and risk of bias for a planned clinical trial.

RESUMO A declaração SPIRIT 2013 tem como objetivo melhorar a integralidade dos relatórios dos protocolos de ensaios clínicos, fornecendo recomendações baseadas em evidências para o conjunto mínimo de itens que devem ser abordados. Essas orientações têm sido fundamentais para promover uma avaliação transparente de novas intervenções. Recentemente, tem-se reconhecido cada vez mais que intervenções que incluem inteligência artificial (IA) precisam ser submetidas a uma avaliação rigorosa e prospectiva para demonstrar seus impactos sobre os resultados de saúde. A extensão SPIRIT-AI (Standard Protocol Items: Recommendations for Interventional Trials - Artificial Intelligence) é uma nova diretriz de relatório para protocolos de ensaios clínicos que avaliam intervenções com um componente de IA. Essa diretriz foi desenvolvida em paralelo à sua declaração complementar para relatórios de ensaios clínicos, CONSORT-AI (Consolidated Standards of Reporting Trials - Artificial Intelligence). Ambas as diretrizes foram desenvolvidas por meio de um processo de consenso em etapas que incluiu revisão da literatura e consultas a especialistas para gerar 26 itens candidatos. Foram feitas consultas sobre esses itens a um grupo internacional composto por 103 interessados diretos, que participaram de uma pesquisa Delphi em duas etapas. Chegou-se a um acordo sobre os itens em uma reunião de consenso que incluiu 31 interessados diretos, e os itens foram refinados por meio de uma lista de verificação piloto que envolveu 34 participantes. A extensão SPIRIT-AI inclui 15 itens novos que foram considerados suficientemente importantes para os protocolos de ensaios clínicos com intervenções que utilizam IA. Esses itens novos devem constar dos relatórios de rotina, juntamente com os itens básicos da SPIRIT 2013. A SPIRIT-AI preconiza que os pesquisadores descrevam claramente a intervenção de IA, incluindo instruções e as habilidades necessárias para seu uso, o contexto no qual a intervenção de IA será integrada, considerações sobre o manuseio dos dados de entrada e saída, a interação humano-IA e a análise de casos de erro. A SPIRIT-AI ajudará a promover a transparência e a integralidade nos protocolos de ensaios clínicos com intervenções que utilizam IA. Seu uso ajudará editores e revisores, bem como leitores em geral, a entender, interpretar e avaliar criticamente o delineamento e o risco de viés de um futuro estudo clínico.

https://doi.org/10.26633/rpsp.2024.12

Directrices para presentación de informes de ensayos clínicos sobre intervenciones con inteligencia artificial: extensión CONSORT-AI
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Liu, Xiaoxuan

; Cruz Rivera, Samantha

; Moher, David

; Calvert, Melanie J.

; Denniston, Alastair K.

; Chan, An-Wen

; Darzi, Ara

; Holmes, Christopher

; Yau, Christopher

; Moher, David

; Ashrafian, Hutan

; Deeks, Jonathan J.

; Ferrante di Ruffano, Lavinia

; Faes, Livia

; Calvert, Melanie J.

; Keane, Pearse A.

; Cruz Rivera, Samantha

; Vollmer, Sebastian J.

; Liu, Xiaoxuan

; Lee, Aaron Y.

; Jonas, Adrian

; Esteva, Andre

; Beam, Andrew L.

; Chan, An-Wen

; Panico, Maria Beatrice

; Lee, Cecilia S.

; Haug, Charlotte

; Kelly, Christophe J.

; Yau, Christopher

; Mulrow, Cynthia

; Espinoza, Cyrus

; Fletcher, John

; Moher, David

; Paltoo, Dina

; Manna, Elaine

; Price, Gary

; Collins, Gary S.

; Harvey, Hugh

; Matcham, James

; Monteiro, Joao

; Khair ElZarrad, M.

; Ferrante di Ruffano, Lavinia

; Oakden-Rayner, Luke

; Calvert, Melanie J.

; McCradden, Melissa

; Keane, Pearse A.

; Savage, Richard

; Golub, Robert

; Sarkar, Rupa

; Rowley, Samuel

Revista Panamericana de Salud Pública

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2024, Volume 48 elocation e13

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

resumen está disponible en el texto completo

ABSTRACT The CONSORT 2010 statement provides minimum guidelines for reporting randomized trials. Its widespread use has been instrumental in ensuring transparency in the evaluation of new interventions. More recently, there has been a growing recognition that interventions involving artificial intelligence (AI) need to undergo rigorous, prospective evaluation to demonstrate impact on health outcomes. The CONSORT-AI (Consolidated Standards of Reporting Trials–Artificial Intelligence) extension is a new reporting guideline for clinical trials evaluating interventions with an AI component. It was developed in parallel with its companion statement for clinical trial protocols: SPIRIT-AI (Standard Protocol Items: Recommendations for Interventional Trials–Artificial Intelligence). Both guidelines were developed through a staged consensus process involving literature review and expert consultation to generate 29 candidate items, which were assessed by an international multi-stakeholder group in a two-stage Delphi survey (103 stakeholders), agreed upon in a two-day consensus meeting (31 stakeholders) and refined through a checklist pilot (34 participants). The CONSORT-AI extension includes 14 new items that were considered sufficiently important for AI interventions that they should be routinely reported in addition to the core CONSORT 2010 items. CONSORT-AI recommends that investigators provide clear descriptions of the AI intervention, including instructions and skills required for use, the setting in which the AI intervention is integrated, the handling of inputs and outputs of the AI intervention, the human–AI interaction and provision of an analysis of error cases. CONSORT-AI will help promote transparency and completeness in reporting clinical trials for AI interventions. It will assist editors and peer reviewers, as well as the general readership, to understand, interpret and critically appraise the quality of clinical trial design and risk of bias in the reported outcomes.

RESUMO A declaração CONSORT 2010 apresenta diretrizes mínimas para relatórios de ensaios clínicos randomizados. Seu uso generalizado tem sido fundamental para garantir a transparência na avaliação de novas intervenções. Recentemente, tem-se reconhecido cada vez mais que intervenções que incluem inteligência artificial (IA) precisam ser submetidas a uma avaliação rigorosa e prospectiva para demonstrar seus impactos sobre os resultados de saúde. A extensão CONSORT-AI (Consolidated Standards of Reporting Trials – Artificial Intelligence) é uma nova diretriz para relatórios de ensaios clínicos que avaliam intervenções com um componente de IA. Ela foi desenvolvida em paralelo à sua declaração complementar para protocolos de ensaios clínicos, a SPIRIT-AI (Standard Protocol Items: Recommendations for Interventional Trials – Artificial Intelligence). Ambas as diretrizes foram desenvolvidas por meio de um processo de consenso em etapas que incluiu revisão da literatura e consultas a especialistas para gerar 29 itens candidatos. Foram feitas consultas sobre esses itens a um grupo internacional composto por 103 interessados diretos, que participaram de uma pesquisa Delphi em duas etapas. Chegou-se a um acordo sobre os itens em uma reunião de consenso que incluiu 31 interessados diretos, e os itens foram refinados por meio de uma lista de verificação piloto que envolveu 34 participantes. A extensão CONSORT-AI inclui 14 itens novos que, devido à sua importância para as intervenções de IA, devem ser informados rotineiramente juntamente com os itens básicos da CONSORT 2010. A CONSORT-AI preconiza que os pesquisadores descrevam claramente a intervenção de IA, incluindo instruções e as habilidades necessárias para seu uso, o contexto no qual a intervenção de IA está inserida, considerações sobre o manuseio dos dados de entrada e saída da intervenção de IA, a interação humano-IA e uma análise dos casos de erro. A CONSORT-AI ajudará a promover a transparência e a integralidade nos relatórios de ensaios clínicos com intervenções que utilizam IA. Seu uso ajudará editores e revisores, bem como leitores em geral, a entender, interpretar e avaliar criticamente a qualidade do desenho do ensaio clínico e o risco de viés nos resultados relatados.

https://doi.org/10.26633/rpsp.2024.13

Estudio técnico-económico de tres alternativas de producción del sistema doble propósito bovino en Meta, Colombia
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Ortiz-Valdes, Ciro

; Barajas-Pardo, Diana Patricia

; Velásquez-Penagos, José Henry

; Rangel-García, Wilson David

; Neira-Rivera, Eliana

; Velásquez-Penagos, José Guillermo

Agronomía Mesoamericana

Journal Metrics
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dec 2023, Volume 34 N. 3 elocation 51254

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción. La rentabilidad del sistema de doble propósito (SDP) está afectada por baja eficiencia productiva y altos costos de producción generados en el manejo tradicional. Estudios en función de la reducción de costos e incremento de los ingresos, podría sugerir estrategias para mejorar la eficiencia económica. Objetivo. Determinar la eficiencia técnica y rentabilidad de tres alternativas de producción del SDP bovino en Meta, Colombia. Materiales y métodos. El estudio se llevó a cabo durante el periodo 2016-2017, en una finca del departamento de Meta, Colombia. Se seleccionaron 72 vacas Bos taurus x Bos indicus, que iniciaban lactancia, alimentadas bajo pastoreo, las vacas seleccionadas y sus crías se distribuyeron en tres grupos: alternativa 1 (MA1): ordeño dos veces por semana hasta el destete a 100 días, alternativa 2 (MA2): ordeño dos veces por semana hasta el destete a 240 días y alternativa 3 (MT): ordeño diario (tradicional), hasta el destete a 240 días. En los terneros se midió el peso al nacimiento y a los 252 días de vida (P252), y se estimó la ganancia de peso diaria (GPD). En las vacas se midió la tasa de terneros nacidos por vaca/año (TN) y la leche producida por lactancia (LPL). Para el análisis económico, los resultados en cada tratamiento se proyectaron para un pie de cría de 100 vacas. Resultados. El P252 y la GPD de los grupos MA1 (189,30 kg; 0,64 kg/animal/día) y MA2 (186,10 kg; 0,63 kg/animal/día) fue similar (p>0,05), pero superiores (p<0,05) a los del MT (155,10 kg; 0,54 kg/animal/día). La TN fue mayor para MA1 (0,84 terneros/vaca/año), seguida por la del MA2 (0,74 terneros/vaca/año) y MT (0,68 terneros/vaca/año). La LPL fue de 1204,36 kg para MT, 303,74 kg para MA2 y 158,75 kg para MA1. La rentabilidad de MA1 superó en 9,5 y 9,2 % a MA2 y MT, respectivamente. Conclusiones. El ordeño dos veces por semana hasta el destete (MA1) reflejó mayor eficiencia económica por efecto del incremento en la tasa de terneros nacidos por vaca/año (TN) y disminución en los costos de producción.

Abstract Introduction. The profitability of the dual-purpose system (DPS) is affected by low production efficiency and high production costs generated in traditional management. Studies based on the reduction of expenses and increase of income, could suggest strategies to improve economic efficiency. Objective. Determine the technical and profitable efficiency of three production alternatives for bovine DPS in Meta, Colombia. Materials and methods. The study was conducted during 2016-2017, on a farm in the department of Meta, Colombia. Seventy-two Bos taurus x Bos indicus cows were selected, starting lactation, fed under grazing, during the period 2016-2017, in a farm in Meta, Colombia. The selected cows and their calves were distributed in three groups; alternative 1 (MA1): milking 2 times a week until weaning at 100 days, alternative 2 (MA2): milking 2 times a week until weaning at 240 days, and traditional (MT): milking daily (traditional) until weaning at 240 days. In the calves, the weight at birth and at 252 days of age (W252) were measured, and the daily weight gain (DWG) was estimated. In the cows, the birth rate (BR) and the milk produced per lactation (MPL) were measured. The productive response fed the economic analysis projected for a breeding stock of 100 cows. Results. The W252 and DWG between MA1 (189.30 kg; 0.64 kg/animal/day) and MA2 (186.10 kg; 0.63 kg/animal/day) groups were similar (P>0.05), but higher (p<0.05) than those of the MT (155.10 kg; 0.54 kg/animal/day). BR presented the highest benefit for MA1 (0.84 calves/cow/year), followed by MA2 (0.74 calves/cow/year), and MT (0.68 calves/cow/year). The MPL was 1204.36 kg for MT, 303.74 kg for MA2 and 158.75 kg for MA1. MA1's profitability outperformed MA2 and MT by 9.5 and 9.2 %, respectively. Conclusions. The MA1 reflected the greater economic efficiency mainly due to the effect of the increase in the BR and the decrease in production costs.

https://doi.org/10.15517/am.2023.51254

Understanding perspectives of current palynology: using science with practical discourse
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Jiménez-Zamora, Tonatiuh

; Galicia, Leopoldo

; Espinosa, David

; Rivera-González, Irán

; Luna-Vega, Isolda

Botanical Sciences

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jun 2023, Volume 101 N. 2 Pages 341 - 357

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background: Palynological studies have contributed with topics closely linked to sustainability. However, there are still few scientific reviews that have discussed the relevance of practical applications in current palynology and its perspectives as a theoretical framework for the study of integrated landscape management. This review shows palynological contributions within agricultural model diversities in both natural and novel ecosystems. Questions: What are the current perspectives and concerns of the mature phase in palynology? What are the approaches of pollen analysis on landscape management and biodiversity conservation? Studied species: Pollen analysis and palynomorphs. Study site and dates: Global literature from current palynology. Methods: Global scientific literature using keywords, theoretical frameworks, and original articles. Results: We identified palynological perspectives for the study of sustainability based on global scientific literature: 1) ecological-evolutionary and 2) interdisciplinary research. In addition, we discussed some synergies and trade-offs between ecosystem services that were recognized through current palynology in different farming landscapes: biodiversity-based farming systems and chemical input-based farming systems. While pollen morphology and descriptive palynology can provide the basis for crop improvement, biological invasions, and the effect of deforestation on native species, more analytical approaches such as land-use indicators are necessary for sustainable management. In addition, we have included some biocultural aspects to conservation, due to a lack of practical discourse in current palynology. Conclusions: Innovative influences from current palynology are powerful approaches to integrated landscape management.

Resumen Antecedentes: Los estudios palinológicos han contribuído con temas relacionados a la sostenibilidad. Sin embargo, existen pocas revisiones científicas que discutan la relevancia de dichas aplicaciones y sus perspectivas como marco teórico para la gestión integrada del paisaje. En la presente revisión, se muestran algunas contribuciones palinológicas en modelos agrícolas, tanto de ecosistemas naturales como novedosos. Preguntas: ¿Cuáles son las perspectivas y preocupaciones actuales de la fase madura palinológica? ¿Cuáles son los enfoques del análisis polínico en el manejo del paisaje y la conservación biológica? Especies de estudio: Análisis polínico y palinomorfos. Sitio y años de estudio: Literatura global y actualizada. Métodos: Literatura científica utilizando palabras clave, marcos teóricos y artículos científicos originales. Resultados: Identificamos dos perspectivas palinológicas para el estudio de la sostenibilidad: 1) una ecológica-evolutiva y 2) la investigación interdisciplinaria. Además, discutimos algunas sinergias y compromisos entre servicios ecosistémicos, a través de la palinología en diversos paisajes: sistemas agrícolas basados en la biodiversidad y en insumos químicos. Si bien la palinología descriptiva y la morfología polínica pueden proveer la base para el mejoramiento de los cultivos, las invasiones biológicas y el efecto de la deforestación sobre especies nativas, los enfoques analíticos con indicadores de uso de suelo son necesarios para una gestión sostenible. Además, incluimos algunos aspectos bioculturales para la conservación, debido a la falta de un discurso práctico y palinológico. Conclusiones: Las influencias innovadoras de la palinología son un enfoque poderoso en la gestión integrada del paisaje.

https://doi.org/10.17129/botsci.3180

Discapacidad visual asociada a retinopatía diabética y edema macular: un estudio de base hospitalaria
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Pérez-Peralta, Liliana

; Rivera-De la Parra, David

; Graue-Hernández, Enrique

; Hernández-Jiménez, Sergio

; Almeda-Valdés, Paloma

; Velázquez-Jurado, Héctor

; Jiménez-Corona, Aída

Gaceta médica de México

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jun 2023, Volume 159 N. 3 Pages 207 - 214

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: Los datos sobre discapacidad visual (DV) en pacientes con diabetes son necesarios para orientar los recursos económicos y humanos que disminuyan su prevalencia. Objetivo: Estimar la prevalencia de DV relacionada con retinopatía diabética en pacientes con diabetes tipo 2 en un entorno hospitalario. Material y métodos: Estudio transversal realizado de 2014 a 2019 en una consulta externa de oftalmología. Cualquier DV se definió como agudeza visual corregida con agujero estenopeico en el ojo con mejor visión (≥ 0.24 logMAR). Se evaluó la presencia de retinopatía diabética, edema macular diabético (EMD) y cataratas. Resultados: Se incluyeron 840 pacientes; la mediana de duración de la diabetes fue de 15 años. La prevalencia de DV fue de 30 %. Se encontró retinopatía diabética en 62 % (30 % tenía retinopatía diabética que amenazaba la visión [RDAV]); 17 %, EMD y 3 %, cataratas. La razón de momios para DV moderada o de mayor gravedad fue de 9.02 para RDAV (p < 0.001), 5.89 para EMD referible (p = 0.001) y 2.51 para catarata (p = 0.006). Conclusión: Treinta por ciento de los participantes tenía algún grado de DV. La DV moderada o de mayor gravedad mostró una fuerte asociación con RDAV y EMD referible.

Abstract Background: Data on visual impairment (VI) in patients with diabetes are necessary in order to guide economic and human resources for reducing its prevalence. Objective: To estimate the prevalence of diabetic retinopathy-related VI in patients with type 2 diabetes in a hospital-based setting. Material and methods: Cross-sectional study carried out from 2014 to 2019 in an ophthalmology outpatient clinic. Any VI was defined as corrected pin-hole visual acuity in the better eye of ≥ 0.24 logMAR. The presence of diabetic retinopathy (DR), diabetic macular edema (DME) and cataract was evaluated. Results: A total of 840 patients were included; median diabetes duration was 15 years. The prevalence of VI was 30 %. DR was found in 62 % of patients (30 % had sight-threatening DR [STDR]), 17 % had referable DME, and 3 %, cataracts. The odds ratio for moderate or worse VI was 9.02 for STDR (p < 0.001), 5.89 for referable DME (p = 0.001), and 2.51 for cataract (p = 0.006). Conclusion: Thirty percent of participants had some degree of VI. Moderate or worse VI showed a strong association with STDR and referable DME.

https://doi.org/10.24875/gmm.23000057

Spanish Burnout Inventory (SBI) Validation among University Professors During COVID-19
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Mendoza-Martínez, Ignacio Alejandro

; García-Rivera, Blanca Rosa

; Hemsworth, David

Investigación administrativa

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jun 2023, Volume 52 N. 131 elocation 00001

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El objetivo fue evaluar la evidencia de la estructura factorial del CESQT en Profesores Universitarios Mexicanos a través de sus patrones de respuesta durante el primer pico de la Pandemia de COVID-19. En el método se consideraron las propiedades psicométricas del instrumento examinando a una muestra de n=600 de Profesores Universitarios Mexicanos. La escala incluía una sección sociodemográfica y el cuestionario CESQT de Gil-Monte (2005). El inventario tiene 20 reactivos agrupados en 4 dimensiones relacionadas con: Ilusión por el trabajo, Cansancio Emocional, Indolencia y Culpa. El análisis factorial, la varianza y covarianza se realizaron usando el método de máxima verosimilitud con AMOS24®. Los resultados del estudio demostraron que el instrumento es valido y confiable para medir los niveles de Burnout en profesores y se encontraron diferencias significativas con los resultados de Gil-Monte. El Coeficiente de Alfa de Cronbach fue mayor a 0.70 para las cuatro escalas del instrumento. El valor original del presente estudio contribuye con el desarrollo del cuerpo de conocimiento acerca del escenario percibido por Profesores Universitarios durante el primer pico de la Pandemia de COVID-19, sobre instrumentos válidos para medir el Síndrome de Burnout en países de habla hispana. Se concluye que los resultados proveen evidencia de las propiedades psicométricas del CESQT para el estudio del Síndrome de Burnout en el contexto cultural mexicano durante el primer pico de la Pandemia de COVID-19. Todas las escalas de medición satisfacen los criterios de validez y confiabilidad. El análisis factorial confirmó el modelo Teórico de cada una de las dimensiones de Gil-Monte de manera empírica.

Abstract: The objective was to evaluate the evidence of the factorial structure of the CESQT in Mexican University Professors through their response patterns during the first peak of the COVID-19 Pandemic. The method considers the psychometric properties of the instrument by examining a sample of n=600 of Mexican University Professors. The scale featured a sociodemographic section and the CESQT questionnaire by Gil-Monte (2005). The inventory has 20 items grouped into 4 dimensions related to: Enthusiasm for work, Emotional Fatigue, Indolence and Guilt. Factor analysis, variance and covariance were performed using the maximum likelihood method with AMOS24®. The results of the study demonstrated that the instrument is valid and reliable to measure Burnout levels in teachers and significant differences were found with the Gil-Monte results. Cronbach's Alpha Coefficient was greater than 0.70 for the four scales of the instrument. The original value of this study contributes to the development of the body of knowledge about the scenario perceived by University Professors during the first peak of the COVID-19 Pandemic, about valid instruments to measure Burnout Syndrome in Spanish-speaking countries. It is concluded that the results provide evidence of the psychometric properties of the CESQT during the study of Burnout Syndrome in the Mexican cultural context, the first peak of the COVID-19 Pandemic. All the measurement scales satisfy the criteria of validity and reliability. The factorial analysis of the Theoretical model of each one of the dimensions of Gil-Monte in an empirical way.

https://doi.org/10.35426/iav52n131.01

Trastornos circadianos del sueño
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Ángeles-Castellanos, Manuel

; Rojas-Granados, Adelina

; Quezada-Martínez, José Rodrigo

; Arellano-Rivera, Esteban

; Ruiz-Jiménez, David Antonio

; Velázquez-Hernández, Oscar Daniel

; Sánchez-Sánchez, Manuel

Revista de la Facultad de Medicina (México)

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apr 2023, Volume 66 N. 2 Pages 40 - 48

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El sistema circadiano está sincronizado al ciclo luz-oscuridad que es generado por la rotación de la tierra, asegurando que la vigilia sea durante el día y que el sueño ocurra durante la noche. Sin embargo, el ritmo de sueño-vigilia puede estar desincronizado del ciclo luz-oscuridad o desincronizado de manera endógena, dando como resultado: insomnio, fatiga y bajo rendimiento en las actividades cotidianas. Mientras que los trastornos del sueño están clasificados por la Asociación Americana de Trastornos del Sueño como: disomnias intrínsecas, disomnias extrínsecas, parasomnias o trastornos del sueño médicos/psiquiátricos. Los trastornos circadianos del sueño se han categorizado por separado, en parte para reconocer que en la mayoría de los casos la etiología de los trastornos circadianos es una mezcla de factores internos y ambientales, o por un desajuste temporal entre ambos. Los síntomas generalmente son insomnio o hipersomnia, síntomas comunes en pacientes con trastornos circadianos del sueño, aunque hay otras causas a las que pueden atribuirse y que deben excluirse antes de realizar el diagnóstico de un trastorno circadiano del sueño. En el paciente sin otra patología del sueño, un registro diario de actividades, comidas, ejercicio, siestas y la hora de acostarse es una herramienta esencial para evaluar los trastornos circadianos del sueño. Estos registros deben mantenerse durante 2 semanas o más, ya que una perturbación debida a cambios de trabajo o viajes a través de zonas horarias puede tener efectos sobre el sueño y el estado de alerta durante el día, semanas después del evento.

Abstract The circadian system is synchronized to the light-dark cycle generated by the rotation of the earth, ensuring that wakefulness is during the day and sleep occurs at night. However, the sleep-wake rhythm may be out of sync with the light-dark cycle or endogenously out of sync, resulting in insomnia, fatigue, and poor performance in activities of daily living. Sleep disorders are classified by the American Sleep Disorders Association, as intrinsic dyssomnias, extrinsic dyssomnias, parasomnias, or medical/psychiatric sleep disorders. Circadian sleep disorders have been categorized separately to recognize that in most cases the etiology of circadian disturbances is a mix of internal and environmental factors or a temporary mismatch between the two. Symptoms are usually insomnia or hypersomnia, common symptoms in patients with circadian sleep disorders although other causes can be attributed and must be excluded before a diagnosis of a circadian sleep disorder is made. In the patient without other sleep pathology, a daily record of activities, meals, exercise, naps, and bedtime is an essential tool in assessing circadian sleep disorders. These records should be kept for 2 weeks or more, as a disturbance due to job changes or travel across time zones can have effects on sleep and daytime alertness weeks after the event.

https://doi.org/10.22201/fm.24484865e.2023.66.2.06

Massive production of Hemileia vastatrix uredospores for inoculation of coffee seedlings
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Hernández-Amasifuen, Angel David

; Rivadeneyra-Chisquipama, Lenin

; Padilla-Dominguez, Amner

; Paredes-Espinosa, Richard

; Guerrero-Abad, Juan Carlos

; Torres-Flores, Elías

; Peláez-Rivera, Jorge Luis

; Carvajal-Vallejos, Fernando Marcelo

; Gutiérrez-Reynoso, Dina Lida

; Corazon-Guivin, Mike Anderson

Scientia Agropecuaria

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apr 2023, Volume 14 N. 2 Pages 259 - 267

Abstract: En | Text: En | PDF: En

Abstract Coffee leaf rust (Hemileia vastatrix) is the most important disease in coffee crops around the world. Currently, there is limited knowledge about mass production methodologies and ex-situ infection of H. vastatrix that lead to the development of different health characterization studies of Coffea or disease phenotyping. In this context, the aim of this research was to develop a simple protocol for the mass production of coffee rust uredospores under controlled conditions and to determine their infection in coffee seedlings. Uredospores of H. vastatrix were collected from infected plants in the “Chontal” coffee-growing area in San Martín, Peru. The viability of uredospore germination was evaluated, and a uredospores suspension (2 x 105 uredospores/mL) was prepared to inoculate coffee seedlings. Incidence and sporulation rates were evaluated after 43 days of inoculation. During the multiplication process of H. vastatrix uredospores, using controlled conditions (23±1 °C, ≈ 80% relative humidity and photoperiod of 16 hours of light) under an innovative system, the first symptoms of chlorosis were observed on coffee leaves 20 days after inoculation. Our findings show a 100% incidence of inoculated coffee plants with an average of 54 mg of H. vastatrix uredospores per plant and a 1.38 x 10-1 mg/cm2 sporulation rate. Finally, here we report a protocol that allows mass multiplication of H. vastatrix uredospores under controlled conditions, that would be useful in any time for coffee leaf rust bioassays.

https://doi.org/10.17268/sci.agropecu.2023.023

Efecto de bioestimulantes microbianos en frutos de chile morrón y jitomate producidos en macrotúnel
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Adame-García, Jacel

; Murillo-Cuevas, Félix David

; Cabrera-Mireles, Héctor

; Villegas-Narváez, Jazmín

; Rivera-Meza, Adriana Elena

; Vásquez-Hernández, Andrés

Biotecnia

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apr 2023, Volume 25 N. 1 Pages 81 - 87

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La producción intensiva de vegetales ha provocado dependencia excesiva de la fertilización química, lo cual ha generado problemas ambientales y de inocuidad de los alimentos. Una opción para reducir la cantidad de fertilizantes sintéticos es el manejo de nutrientes mediante inoculaciones microbianas. El objetivo fue evaluar el efecto de dos bioestimulantes a base de Trichoderma spp. y uno de Bacillus spp. en el diámetro, longitud y peso de frutos de chile morrón y jitomate en condiciones de macrotúnel. Los tratamientos fueron: Genifix®, T22®, Mix® y testigo. Se utilizó un diseño experimental en bloques al azar con cuatro repeticiones. Se utilizaron tres cortes de frutos por cultivo. Las variables de respuesta fueron: peso, diámetro y longitud de fruto, además del peso de 20 frutos elegidos al azar. Los frutos obtenidos con el tratamiento Genifix fueron de mayor tamaño y peso, con diferencias significativas al resto de los tratamientos. El T22 y Mix mostraron un efecto significativo con frutos más grandes y pesados en comparación a frutos testigo en la mayoría de los cortes. Los bioestimulantes evaluados mejoraron el tamaño y peso de frutos de chile morrón y jitomate en plantas con un manejo mínimo tradicional de fertilización en condiciones de macrotúnel.

Abstract The intensive production of vegetables has caused excessive dependence on chemical fertilization, which has generated environmental and food safety problems. An option to reduce the amount of synthetic fertilizers is the management of nutrients through microbial inoculations. The objective of this study was to evaluate the effect of two biostimulants based on Trichoderma spp. and one from Bacillus spp., on the diameter, length and weight of bell pepper and tomato fruits under macrotunnel conditions. The treatments were: Genifix®, T22®, Mix® and control (blank). A completely randomized block design with four repetitions was used. Three harvests were made per crop. The response variables were: weight, diameter and fruit length, in addition to the weight of 20 fruits chosen at random. The fruits obtained with the Genifix treatment were larger and heavier, with significant differences from the rest of the treatments. The T22 and Mix also showed a significant effect on the development of larger and heavier fruits in relation to the control in most harvests. The evaluated biostimulants improved the size and weight of bell pepper and tomato fruits in plants with minimal traditional fertilization management under macrotunnel conditions.

https://doi.org/10.18633/biotecnia.v25i1.1772

10.

Neumoencéfalo, una revisión de literatura
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Gómez G., Matías

; Rojas Z., David

; Melo M., Rómulo

; Rivera C., Belén

; Contreras H., Francisca

Revista de otorrinolaringología y cirugía de cabeza y cuello

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mar 2023, Volume 83 N. 1 Pages 86 - 91

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El neumoencéfalo corresponde a la presencia de aire intracraneal y, en general, es asintomático y autolimitado. Puede ocurrir posterior a trauma, cirugía craneofacial, defectos congénitos, infección, neoplasia o de forma espontánea. El neumoencéfalo a tensión es una emergencia neuroquirúrgica, en la que se acumula aire intracraneal de forma continua que genera un efecto de masa. Clínicamente, se caracteriza por cefalea y un deterioro neurológico marcado. A pesar de ser poco frecuente, es relevante considerar el neumoencéfalo a tensión como una posible complicación en pacientes con antecedente de neurocirugía y/o cirugía otorrinolaringológica, debido a que es una patología potencialmente grave. El diagnóstico es clínico e imagenológico, y requiere de un alto índice de sospecha. Un manejo oportuno es relevante para prevenir la herniación y la muerte.

Abstract Pneumocephalus refers to the presence of air in the cranial cavity, and in general, is self-limited and asymptomatic. It can occur after trauma, craniofacial surgery, due to congenital defects, infection, neoplasia or spontaneously. Tension pneumocephalus is a neurosurgical emergency in which intracranial air accumulates continuously, causing a mass effect. It presents with headache and marked neurological deterioration. Despite being rare, it is relevant to consider tension pneumocephalus as a possible complication in patients with a history of neurosurgery and/or otolaryngology surgery, as it can be life-threatening. Diagnosis requires a high index of suspicion and imagenologic confirmation. Timely management is relevant to prevent herniation and death.

11.

A commentary on "Surgical results of Hartmann procedure in emergency cases with the left-sided colorectal cancer"
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Rodríguez-Gutiérrez, María Manuela

; Santa-Gil, Valentina

; Lozada-Martínez, Ivan David

; Díaz-Rivera, María Carolina

Cirugía y cirujanos

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feb 2023, Volume 91 N. 1 Pages 141 - 142

Abstract: En | Text: En | PDF: En

https://doi.org/10.24875/ciru.21000479

12.

Manipulación abdominal y otros factores de riesgo culturales asociados a complicación de apendicitis aguda en pacientes pediátricos
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Aguilar-Andino, David

; Licona Rivera, Tania Soledad

; Osejo Quan, Jorge Alberto

; Carranza Linares, Ricardo Jafet

; Molina Soto, Marco Antonio

; Alas-Pineda, César

Andes pediatrica

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jan 2023, Volume 94 N. 1 Pages 45 - 53

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: La apendicitis aguda (AA) en niños usualmente es confundida con empacho, enfermedad que, según creencia popular, se produce por ingesta de alimentos mal cocidos o fríos causando síntomas gastrointestinales. El tratamiento empírico es la manipulación abdominal, que consiste en masaje con distintas maniobras sobre la pared abdominal, acompañado de remedios caseros. Se desconoce el efecto de dichas terapias en la evolución de AA. Objetivo: Determinar la asociación entre manipulación abdominal y AA complicada en pacientes pediátricos. Pacientes y Método: Estudio de casos y controles en menores de 18 años, con cuadro de abdomen agudo, intervenidos quirúrgicamente por AA, en un centro hospitalario de Honduras. Se definió como casos los pacientes con AA complicada y controles aquellos con AA simple. Se empleó un modelo regresión logística binaria para determinar los factores de riesgo asociados a complicaciones de AA. Resultados: Se enrolaron 31 casos y 31 controles, mediana de edad 11 años. El 58,1% procedía de una zona urbana. El 77,4% de los casos y 9,7% de los controles tuvo antecedente de manipulación abdominal. El síntoma inicial más frecuente fue dolor abdominal. En análisis univariado el sexo masculino, tiempo de evolución prolongado, uso de remedios caseros, leucocitosis > 20,000/mm3 y manipulación abdominal fueron factores de riesgo para AA complicada. En modelo multivariado, la manipulación abdominal fue el principal factor de riesgo (OR 15,94 [3,40-74,59]). Conclusión: Creencias culturales como el empacho y sus respectivos tratamientos como la manipulación abdominal y los remedios caseros, son factores de riesgo para la complicación de un cuadro instaurado de AA, así mismo contribuyen al retraso diagnóstico.

Abstract: In children, acute appendicitis (AA) is usually mistaken for empacho, which, according to popular belief, is caused by the ingestion of undercooked or cold food causing gastrointestinal symptoms. The empirical treatment is abdominal manipulation, consisting of massages with different maneuvers on the abdominal wall, accompanied by home remedies. The effect of these therapies in the presence of AA is unknown. Objective: To determine the association between abdominal manipulation and complicated AA in pediatric patients. Patients and Method: Case-control study in a pediatric population under 18 years of age, with acute abdomen symptoms, who underwent surgery for AA, in a tertiary health institution in Honduras. Cases were defined as patients with complicated AA and controls as those with simple AA. A binary logistic regression model was used to determine the risk factors associated with complications of AA. Results: Sixty-two pediatric patients were analyzed (31 cases and 31 controls) with a median age of 11 years. 58.1% were from an urban area. 77.4% of the cases and 9.7% of controls had a history of abdominal manipulation. The most frequent initial symptom was abdominal pain. In the univariate analysis, male sex, prolonged evolution time, use of home remedies, leukocytosis > 20,000/mm3, and abdominal manipulation were risk factors for complicated AA. In the multivariate model, abdominal manipulation was the main risk factor (OR 15.94 [3.4074.59]). Conclusion: Cultural beliefs such as empacho and its respective treatments such as abdominal manipulation and use of home remedies are risk factors for the complication of an established AA case, as well as contributing to the delay in diagnosis.

https://doi.org/10.32641/andespediatr.v94i1.4218

13.

Directrices para los protocolos de ensayos clínicos de intervenciones con inteligencia artificial: la extensión SPIRIT-AI
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Cruz Rivera, Samantha

; Liu, Xiaoxuan

; Chan, An-Wen

; Denniston, Alastair K.

; Calvert, Melanie J.

; Denniston, Alastair K.

; Chan, An-Wen

; Darzi, Ara

; Holmes, Christopher

; Yau, Christopher

; Moher, David

; Ashrafian, Hutan

; Deeks, Jonathan J.

; Ferrante di Ruffano, Lavinia

; Faes, Livia

; Calvert, Melanie J.

; Keane, Pearse A.

; Cruz Rivera, Samantha

; Vollmer, Sebastian J.

; Liu, Xiaoxuan

; Lee, Aaron Y.

; Jonas, Adrian

; Esteva, Andre

; Beam, Andrew L.

; Chan, An-Wen

; Panico, Maria Beatrice

; Lee, Cecilia S.

; Haug, Charlotte

; Kelly, Christophe J.

; Yau, Christopher

; Mulrow, Cynthia

; Espinoza, Cyrus

; Fletcher, John

; Moher, David

; Paltoo, Dina

; Manna, Elaine

; Price, Gary

; Collins, Gary S.

; Harvey, Hugh

; Matcham, James

; Monteiro, Joao

; Khair ElZarrad, M.

; Ferrante di Ruffano, Lavinia

; Oakden-Rayner, Luke

; Calvert, Melanie J.

; McCradden, Melissa

; Keane, Pearse A.

; Savage, Richard

; Golub, Robert

; Sarkar, Rupa

; Rowley, Samuel

Revista Panamericana de Salud Pública

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2023, Volume 47 elocation e149

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

resumen está disponible en el texto completo

https://doi.org/10.26633/rpsp.2023.149

14.

Taquicardia ventricular asociada a mutación en el gen de ankirina B
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Vega-Espinosa, David A.

; Campo-Rivera, Natalia

; Bedoya-Tovar, David

; Gil-Roncancio, Efraín

Revista Colombiana de Cardiología

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dec 2022, Volume 29 Suppl. 4 Pages 42 - 46

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract We report a case of a 14-year-old with tachycardiomyopathy due to ventricular tachycardia. A variant of uncertain significance of the ANK2 gene was identified, which is suggestive of a possible ankyrin-B syndrome. The patient underwent a successful radiofrequency ablation. After the procedure, the patient completely recovered her left ventricular function and there was resolution of the premature ventricular complexes and ventricular tachycardia.

Resumen Se presenta el caso de una mujer de 14 años, con taquicardiomiopatía secundaria a taquicardia ventricular. Se evidenció la presencia de una variante de significado incierto en el gen ANK2, por lo que se consideró un posible síndrome de ankirina B. La paciente fue tratada con éxito a través de ablación con radiofrecuencia. Tras dicho procedimiento, tuvo recuperación completa de su función ventricular izquierda y resolución de los complejos ventriculares prematuros y los episodios de taquicardia ventricular.

https://doi.org/10.24875/rccar.m22000193

15.

Non-alcoholic fatty liver disease and thrombocytopenia IV: its association with granulocytopenia
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Rivera-Álvarez, Montserrat

; Córdova-Ramírez, Alejandra Carmina

; Elías-De-La-Cruz, Gilberto David

; Murrieta-Álvarez, Iván

; León-Peña, Andrés Aurelio

; Cantero-Fortiz, Yahveth

; Olivares-Gazca, Juan Carlos

; Ruiz-Delgado, Guillermo José

; Ruiz-Argüelles, Guillermo José

Hematology, Transfusion and Cell Therapy

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oct 2022, Volume 44 N. 4 Pages 491 - 496

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: We have previously shown that some patients present thrombocytopenia (less than 100 × 109/L platelets) in non-alcoholic fatty liver disease (NAFLD). To further explore the nature of this association, we have now analyzed the association of thrombocytopenia with neutropenia (less than 0.5 × 109/L granulocytes) in NAFLD. Material and methods: Persons with NAFLD were prospectively accrued in the study after February 2018. The presence of NAFLD was defined by both serologic determinations (Fibromax ®) and liver transient elastography (TE/Fibroscan ®). Results: In 123 consecutive patients with NAFLD without cirrhosis, thrombocytopenia was identified in 20 (16%), whereas neutropenia was identified in 9 (7%). In the subset of 20 patients with NAFLD and thrombocytopenia, granulocytopenia was identified in 5 (25%), whereas in the subset of 9 patients with granulocytopenia, thrombocytopenia was identified in 5 (55%). We found a significant association between thrombocytopenia and both leukopenia and granulocytopenia (OR 8.25, 95% CI 1.9–34.2, p = 0.004). Conclusions: Both thrombocytopenia and neutropenia were identified in persons with NAFLD and, as there is a significant relationship between these two variables, we speculate that this finding may support the possibility of hypersplenism being involved in the cytopenias found in NAFLD without cirrhosis.

https://doi.org/10.1016/j.htct.2021.06.004

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