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Objective: To evaluate the factor structure, reliability, and validity of the Brazilian version of the Suicide Crisis Inventory-2 (SCI-2) among Brazilian adults. Methods: The SCI-2 was cross-culturally adapted into Portuguese and administered to 2,265 Brazilian participants. Confirmatory factor analysis (CFA) was used to assess factor structure, internal consistency, convergent validity, and criterion validity by using measures such as suicidal narratives, stressful life events, suicidal ideation, and suicide attempts. Results: The revised one-factor model of the SCI-2 demonstrated an adequate, although not optimal, model fit (χ2[1539] = 31,442.79, p < 0.001, comparative fit index [CFI] = 0.99, Tucker-Lewis index [TLI] = 0.99, root mean square error of approximation [RMSEA] = 0.09, standardized root mean residual [SRMR] = 0.05). The revised five-factor model, on the other hand, demonstrated good fit (χ2[1529] = 14,174.86, p < 0.001, CFI = 1.00, TLI = 1.00, RMSEA = 0.06, SRMR = 0.04). Comparison of these two models indicated that the five-factor model had a better fit than the one-factor model. Both the total and subscale scores of the SCI-2 showed strong internal consistency and good convergent and criterion validity in relation to stressful life events, suicidal narratives (excluding the goal disengagement subscale), suicidal ideation, and suicide attempts. Conclusion: Our findings suggest that the Brazilian version of the SCI-2 is a valid tool for assessing symptoms of suicidal crisis syndrome. Objective structure reliability Inventory2 Inventory 2 Inventory- SCI2 SCI (SCI-2 adults Methods SCI- crossculturally cross culturally 2265 265 2,26 participants CFA (CFA events ideation attempts Results onefactor one adequate optimal χ21539 χ χ2 1539 (χ2[1539 3144279 31 442 79 31,442.79 0001 0 001 0.001 [CFI 099 99 0.99 TuckerLewis Tucker Lewis [TLI [RMSEA 009 09 0.09 [SRMR 0.05. 005 0.05 . 05 0.05) fivefactor five hand χ21529 1529 (χ2[1529 1417486 14 174 86 14,174.86 100 1 00 1.00 006 06 0.06 0.04. 004 0.04 04 0.04) excluding subscale, , subscale) Conclusion syndrome (SCI- 226 26 2,2 χ2153 153 (χ2[153 314427 3 44 7 31,442.7 000 0.00 9 0.9 0.0 χ2152 152 (χ2[152 141748 17 8 14,174.8 10 1.0 (SCI 22 2, χ215 15 (χ2[15 31442 4 31,442. 0. 14174 14,174. 1. χ21 (χ2[1 3144 31,442 1417 14,174 (χ2[ 314 31,44 141 14,17 (χ2 31,4 14,1 (χ 31, 14,