Resumo O presente estudo avaliou a incorporação de finos de rocha granítica (GRP) e areia artificial (MS) em argamassas auto-adensáveis (SCM), visando adequação das características reológicas. Foram analisadas SCMs com relações água/cimento de 0,42, 0,46 e 0,63, teores de GRP de 17%, 20% e 40%, respetivamente, e substituição volumétrica de 50% da areia natural por MS. Para avaliar o desempenho das SCMs, foram realizados ensaios de mini V-Funnel e mini Slump, além da caraterização físico-mecânica. A distância de separação interpartículas e a espessura máxima da pasta também foram analisadas e concluiu-se que o teor de GRP é o parâmetro de maior influência no consumo de superplastificante e no tempo de escoamento das misturas. Com a incorporação de GRP, a viscosidade da argamassa foi ajustada sem a necessidade de adição de agentes modificadores de viscosidade, aumentando o tempo de escoamento, enquanto a substituição parcial de NS por MS resultou numa diminuição deste parâmetro. Além disso, a incorporação simultânea de GRP e MS aumentou a densidade das misturas, promovendo aumento da resistência à compressão em até 29% e da resistência à tração na flexão em até 19%, apesar da redução de cerca de 40% do volume de cimento. (GRP (MS autoadensáveis auto adensáveis SCM, SCM , (SCM) reológicas águacimento água cimento 042 0 42 0,42 046 46 0,4 063 63 0,63 17 17% 20 40 respetivamente 50 VFunnel V Funnel Slump físicomecânica. físicomecânica físico mecânica. mecânica físico-mecânica concluiuse concluiu se misturas disso 29 19 19% (SCM 04 4 0, 06 6 0,6 1 2 5

Abstract The study assessed the use of granitic rock powder (GRP) and manufactured sand (MS) in self-compacting mortars (SCM) to achieve desired rheological properties. Different water/cement ratios of 0.42, 0.46, and 0.63 were used with partial replacement of cement volume by GRP at levels of 17%, 20%, and 40%. Additionally, a volumetric replacement of 50% natural sand with MS was studied. The performance of SCMs was evaluated using mini V-Funnel and mini Slump Tests, as well as physical-mechanical characterization. It was found that GRP content significantly influenced superplasticizer consumption and flow time without requiring additional viscosity modifiers while incorporating MS decreased flow time parameter. Furthermore, simultaneous incorporation of GRP and MS increased mixture density by up to 14% improved compressive strength by up to 29%, and flexural tensile strength by up to19%. (GRP (MS selfcompacting self compacting SCM (SCM properties watercement water 042 0 42 0.42 046 46 0.46 063 63 0.6 17 17% 20 20% 40 40% Additionally 50 studied VFunnel V Funnel Tests physicalmechanical physical mechanical characterization parameter Furthermore 14 29 29% to19 to19% 04 4 0.4 06 6 0. 1 2 5 to1

Abstract Background: Testosterone deficiency (TD) is a prevalent condition in our midst and still very neglected. Arterial hypertension (AH) is one of the possible associated factors. Objectives: To determine the prevalence of TD in a hypertensive male population and the factors associated with its occurrence, such as age, time since hypertension diagnosis, number of antihypertensive classes, body mass index (BMI), diabetes, dyslipidemia, chronic kidney disease (CKD), positive symptoms of TD (positive ADAM questionnaire) and use of spironolactone. Methods: Cross-sectional study with administration of the ADAM questionnaire, assessment of biochemical, clinical, and anthropometric data. Patients were stratified into DT and normal testosterone groups. Categorical variables were compared using the chi-squared test and continuous variables using the Mann-Witney test; variables with significance (p<0,05) were analyzed by multivariable linear regression. Results: The prevalence of TD was 26.36%. There was an association between TD and body mass index (BMI) (p=0.0007) but there was no association with age (p=0.0520), time of hypertension diagnosis (p=0.1418), number of classes of antihypertensive drugs (p=0.732), diabetes (p=0.1112); dyslipidemia (p=0.3888); CKD (p=0.3321); use of spironolactone (p=0.3546) or positive ADAM questionnaire (p=0.2483). Conclusions: TD was highly prevalent and positively associated with BMI. Total testosterone (TT) declined by 8.44ng/dL with a one unit increase in BMI and dropped by 3.79ng/dL with a one-year increase in age. Background (TD neglected AH (AH Objectives occurrence BMI, , CKD, (CKD) Methods Crosssectional Cross sectional biochemical clinical data groups chisquared chi squared MannWitney Mann Witney p<0,05 p005 p 0 05 (p<0,05 regression Results 2636 26 36 26.36% (BMI p=0.0007 p00007 0007 (p=0.0007 p=0.0520, p00520 p=0.0520 0520 (p=0.0520) p=0.1418, p01418 p=0.1418 1418 (p=0.1418) p=0.732, p0732 p=0.732 732 (p=0.732) p=0.1112 p01112 1112 (p=0.1112) p=0.3888 p03888 3888 (p=0.3888) p=0.3321 p03321 3321 (p=0.3321) p=0.3546 p03546 3546 (p=0.3546 p=0.2483. p02483 p=0.2483 . 2483 (p=0.2483) Conclusions TT (TT 844ngdL ngdL 8 44ng dL ng 379ngdL 3 79ng oneyear year (CKD p<0,0 p00 (p<0,0 263 2 26.36 p=0.000 p0000 000 (p=0.000 p0052 p=0.052 052 (p=0.0520 p0141 p=0.141 141 (p=0.1418 p073 p=0.73 73 (p=0.732 p=0.111 p0111 111 (p=0.1112 p=0.388 p0388 388 (p=0.3888 p=0.332 p0332 332 (p=0.3321 p=0.354 p0354 354 (p=0.354 p0248 p=0.248 248 (p=0.2483 p<0, p0 (p<0, 26.3 p=0.00 p000 00 (p=0.00 p=0.05 (p=0.052 p014 p=0.14 14 (p=0.141 p07 p=0.7 7 (p=0.73 p=0.11 p011 11 (p=0.111 p=0.38 p038 38 (p=0.388 p=0.33 p033 33 (p=0.332 p=0.35 p035 35 (p=0.35 p024 p=0.24 24 (p=0.248 p<0 (p<0 26. p=0.0 (p=0.0 (p=0.05 p01 p=0.1 1 (p=0.14 p=0. (p=0.7 (p=0.11 p=0.3 p03 (p=0.38 (p=0.33 (p=0.3 p02 p=0.2 (p=0.24 p< (p< (p=0. (p=0.1 p=0 (p=0.2 (p (p=0 p= (p=

Resumo Fundamento: A deficiência de testosterona (DT) é uma condição prevalente em nosso meio e ainda muito negligenciada. A hipertensão arterial (HA) é um de seus possíveis fatores associados. Objetivos: Determinar a prevalência de DT em uma população masculina hipertensa e os fatores associados à sua ocorrência, como idade, tempo de diagnóstico de HA, número de classes de anti-hipertensivos, índice de massa corporal (IMC), diabetes, dislipidemia, doença renal crônica (DRC), sintomas positivos de DT (questionário ADAM positivo) e uso de espironolactona. Métodos: Estudo transversal com aplicação do questionário ADAM, e avaliação de dados bioquímicos, clínicos e antropométricos. Os pacientes foram estratificados em grupos de DT e testosterona normal. As variáveis categóricas foram comparadas pelo teste do qui-quadrado e as variáveis contínuas pelo teste de Mann-Witney; as variáveis com significância (p<0,05) foram submetidas à regressão linear multivariada. Resultados: A prevalência de DT foi de 26,8%. Houve associação entre DT e IMC (p=0,0007), mas não houve com idade (p=0,0520), tempo de diagnóstico de HA (p=0,1418), número de classes de anti-hipertensivos (p=0,0732), diabetes (p=0,1112); dislipidemia (p=0,3888); presença de DRC (p=0,3321); uso de espironolactona (p=0,3546) e questionário ADAM positivo (p=0,2483). Conclusões: A prevalência de DT foi alta e houve associação positiva com IMC. A testosterona total (TT) declinou 8,44 ng/dL com o aumento de 1 kg/m2 no IMC e caiu 3,79 ng/dL com o avanço em um ano na idade. Fundamento (DT negligenciada (HA Objetivos ocorrência antihipertensivos, antihipertensivos anti hipertensivos, hipertensivos IMC, , (IMC) DRC, (DRC) Métodos bioquímicos antropométricos normal quiquadrado qui quadrado MannWitney Mann Witney Mann-Witney p<0,05 p005 p 0 05 (p<0,05 multivariada Resultados 268 26 8 26,8% p=0,0007, p00007 p=0,0007 0007 (p=0,0007) p=0,0520, p00520 p=0,0520 0520 (p=0,0520) p=0,1418, p01418 p=0,1418 1418 (p=0,1418) p=0,0732, p00732 p=0,0732 0732 (p=0,0732) p=0,1112 p01112 1112 (p=0,1112) p=0,3888 p03888 3888 (p=0,3888) p=0,3321 p03321 3321 (p=0,3321) p=0,3546 p03546 3546 (p=0,3546 p=0,2483. p02483 p=0,2483 . 2483 (p=0,2483) Conclusões TT (TT 844 44 8,4 ngdL ng dL kgm2 kgm kg m2 m kg/m 379 3 79 3,7 (IMC (DRC p<0,0 p00 (p<0,0 2 26,8 p0000 p=0,000 000 (p=0,0007 p0052 p=0,052 052 (p=0,0520 p0141 p=0,141 141 (p=0,1418 p0073 p=0,073 073 (p=0,0732 p=0,111 p0111 111 (p=0,1112 p=0,388 p0388 388 (p=0,3888 p=0,332 p0332 332 (p=0,3321 p=0,354 p0354 354 (p=0,354 p0248 p=0,248 248 (p=0,2483 84 4 8, 37 7 3, p<0, p0 (p<0, 26, p000 p=0,00 00 (p=0,000 p=0,05 (p=0,052 p014 p=0,14 14 (p=0,141 p007 p=0,07 07 (p=0,073 p=0,11 p011 11 (p=0,111 p=0,38 p038 38 (p=0,388 p=0,33 p033 33 (p=0,332 p=0,35 p035 35 (p=0,35 p024 p=0,24 24 (p=0,248 p<0 (p<0 p=0,0 (p=0,00 (p=0,05 p01 p=0,1 (p=0,14 (p=0,07 (p=0,11 p=0,3 p03 (p=0,38 (p=0,33 (p=0,3 p02 p=0,2 (p=0,24 p< (p< p=0, (p=0,0 (p=0,1 (p=0, (p=0,2 (p p=0 (p=0 p= (p=

RESUMEN Objetivo: investigar la prevalencia de somnolencia diurna excesiva entre técnicos de enfermería y la asociación con la calidad del sueño y la memoria. Métodos: estudio transversal, inferencial, realizado en una unidad hospitalaria del estado de Goiás entre diciembre de 2020 y enero de 2021. Las evaluaciones se realizaron mediante la Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index y Prospective and Retrospective Memory Questionnaire, instrumentos validados para el contexto brasileño. Se realizaron análisis de regresión logística bivariados y multivariados. Resultados: la muestra estuvo compuesta por 189 técnicos de enfermería con una prevalencia de 40,9% de somnolencia diurna excesiva. En modelos multivariados, la somnolencia diurna excesiva no se asoció con la calidad del sueño, sin embargo, hubo una asociación significativa con fallas generales de memoria. Conclusiones: los resultados del estudio demuestran una alta ocurrencia de somnolencia diurna excesiva, asociación con fallas de memoria general y la necesidad de intervenciones psicosociales para los técnicos de enfermería. Objetivo Métodos transversal inferencial 202 2021 Scale Questionnaire brasileño multivariados Resultados 18 409 40 9 40,9 embargo Conclusiones 20 1 4 40, 2

RESUMO Objetivo: investigar a prevalência de sonolência diurna excessiva entre técnicos de enfermagem e a associação com a qualidade do sono e memória. Métodos: estudo transversal, inferencial, realizado em uma unidade hospitalar no estado de Goiás entre dezembro de 2020 e janeiro de 2021. As avaliações foram realizadas por meio da Epworth Sleepiness Scale, do Pittsburgh Sleep Quality Index e da Prospective and Retrospective Memory Questionnaire, instrumentos validados para o contexto brasileiro. Foram realizadas análises de regressão logística bivariada e multivariada. Resultados: a amostra composta por 189 técnicos de enfermagem com prevalência de 40,9% de sonolência diurna excessiva. Em modelos multivariados, a sonolência diurna excessiva não associou com a qualidade do sono, no entanto houve associação significativa com falhas de memória geral. Conclusões: os resultados do estudo demonstram elevada ocorrência de sonolência diurna excessiva, associação com falhas de memória geral e a necessidade de intervenções psicossociais para técnicos de enfermagem. Objetivo Métodos transversal inferencial 202 2021 Scale Questionnaire brasileiro multivariada Resultados 18 409 40 9 40,9 multivariados Conclusões 20 1 4 40, 2

ABSTRACT Objective: to investigate excessive daytime sleepiness prevalence among nursing technicians and the association with sleep quality and memory. Methods: a cross-sectional, inferential study, carried out in a hospital unit in the state of Goiás between December 2020 and January 2021. Assessments were carried out using the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index and the Prospective and Retrospective Memory Questionnaire, instruments validated for the Brazilian context. Bivariate and multivariate logistic regression analyzes were performed. Results: the sample consisted of 189 nursing technicians with a 40.9% excessive daytime sleepiness prevalence. In multivariate models, excessive daytime sleepiness was not associated with sleep quality, however there was a significant association with overall memory failures. Conclusions: study results demonstrate a high excessive daytime sleepiness occurrence, an association with overall memory failures and the need for psychosocial interventions for nursing technicians. Objective Methods crosssectional, crosssectional cross sectional, sectional cross-sectional 202 2021 Scale Questionnaire context performed Results 18 409 40 9 40.9 models Conclusions occurrence 20 1 4 40. 2

ABSTRACT OBJECTIVE To identify risk factors for death from influenza A(H1N1), including the effectiveness of the vaccine against influenza A(H1N1) concerning mortality. METHODS A case-control of incident cases of influenza A(H1N1) reported in the epidemiological information systems of the states of São Paulo, Paraná, Pará, Amazonas, and Rio Grande do Sul was conducted. RESULTS 305 participants were included, 70 of them cases and 235 controls, distributed as follows: Amazonas, 9 cases/10 controls; Pará, 22 cases/77 controls, São Paulo, 19 cases/49 controls; Paraná, 10 cases/54 controls; Rio Grande do Sul, 10 cases/45 controls. These participants had a mean age of 30 years, with 33 years among cases and 25 years among controls. There was a predominance of females both among the cases and controls. Biological (age), pre-existing diseases (congestive heart failure, respiratory disease, and diabetes mellitus), and care factors (ICU admission) associated with death from influenza A(H1N1) were identified. CONCLUSION The risk factors identified in this investigation not only allowed subsidizing the elaboration of clinical conducts but also indicate important aspects for facing “new” influenza epidemics that are likely to occur in our country.

Background: In June 2009, the World Health Organization (WHO) raised the global alert level for the A(H1N1)pdm09 influenza pandemic and at that time sustained transmission in Brazil was established. It was urgent to carry out studies that evaluated possible risk factors for death from Influenza A(H1N1) to improve case management strategies to reduce the lethality of the disease. This study aimed to identify risk factors for death from Influenza A(H1N1), including the effectiveness of the vaccine against influenza A(H1N1) concerning mortality. Methods: A case-control of incident cases of influenza A(H1N1) reported in the Epidemiological Information Systems of the states of São Paulo, Paraná, Pará, Amazonas, and Rio Grande do Sul was conducted. Results: 305 participants were included, 70 of them cases and 235 controls, distributed as follows: Amazonas – 9 cases/10 controls, Pará – 22 cases/77 controls, São Paulo – 19 cases/49 controls, Paraná – 10 cases/54 controls, Rio Grande do Sul – 10 cases/45 controls. These participants had a mean age of 30 years, with 33 years among cases and 25 years among controls. There was a predominance of females both among cases and controls. Biological (age), pre-existing diseases (congestive heart failure, respiratory disease, and diabetes mellitus), and care factors (ICU admission) associated with death from Influenza A(H1N1) were identified. Conclusion: The risk factors identified in this investigation allowed subsidizing the elaboration of clinical conducts, but also indicate important aspects for facing “new” influenza epidemics that are likely to occur in our country.

Abstract Due to the public health impact that Covid-19 has caused worldwide and reinforcing the need to develop research aimed at pediatric patients affected by Covid-19, this study aimed to identify the epidemiological profile of suspected cases of Covid-19 in children hospitalized in a university hospital in Minas Gerais. This is an epidemiological, descriptive, cross-sectional study carried out in the pediatrics department of a university hospital in Minas Gerais, Brazil. The data was collected between the period from July 2020 to December 2021. For data collection, a spreadsheet containing data related to the variables was used: sex, age, race, clinical manifestation, pre-existing condition, use of oxygen therapy, mean length of stay, and mortality rate. Data were organized into tables and analyzed based on absolute frequencies and percentages. Of the 268 children, 14 (5.22%) were diagnosed with SARS-CoV-2 virus antigens. It is possible to conclude that there was a higher prevalence of the age group 0 to 2 years (53.36%), males (57.47%), and mixed race/color (68.65%). The main clinical manifestations presented were respiratory, fever, and gastrointestinal symptoms. They had an average hospital stay of 6.5 days. It was found that 20.52% had some pre-existing condition, and 58.12% used some oxygen therapy. The production of data on Covid-19 in a hospitalized pediatric population may contribute to a better understanding of the disease and an effective and practical observation for a better understanding by health professionals, aiming at early diagnosis, adequate treatment, and knowledge of essential aspects of the disease.

Resumo Frente ao impacto na saúde pública que a Covid-19 tem causado em todo o mundo, reforçando a necessidade do desenvolvimento de pesquisas voltadas para os pacientes pediátricos afetados pela Covid-19, este estudo tem como objetivo: identificar o perfil epidemiológico dos casos suspeitos de Covid-19 de crianças internadas em um hospital universitário de Minas Gerais. Trata-se de um estudo epidemiológico, descritivo, transversal, realizado na pediatria de um hospital universitário de Minas Gerais, Brasil. Os dados foram coletados entre o período de julho de 2020 a dezembro de 2021. Para a coleta de dados consistiu nas variáveis: sexo, idade, raça, manifestação clínica, condição preexistente, uso de oxigenoterapia, tempo médio de internação e coeficiente de mortalidade. Os dados foram organizados em tabelas e analisados com base em frequências absolutas e percentuais. Dentre as 268 crianças inclusas, 14 (5.22%) foram diagnosticadas com presença de antígenos do vírus SARS-CoV-2. Os resultados permitem concluir que houve maior prevalência da faixa etária 0 a 2 anos (53.36%), do sexo masculino (57.47%) e da raça/cor parda (68.65%). As principais manifestações clínicas apresentadas foram os sintomas respiratórios, febre e sintomas gastrointestinais, apresentando uma média de internação de 6.5 dias. Verificou -se que 20.52% apresentaram alguma condição de saúde preexistente e 58.12% usaram algum tipo de oxigenoterapia. A produção de dados sobre a Covid-19 em população pediátrica hospitalizada poderá contribuir para melhor entendimento da doença, e para uma observação eficaz e melhor compreensão por parte dos profissionais de saúde, visando ao diagnóstico precoce, tratamento adequado e conhecimento de aspectos importantes da doença.

Resumen Objetivo Evaluar la precisión, utilidad, reproducibilidad y aplicabilidad del Sistema de Alerta Precoz Infantil (SAPI) en la identificación del deterioro clínico en niños y adolescentes hospitalizados. Métodos Estudio de prueba diagnóstica, prospectiva, realizada entre octubre de 2018 y octubre de 2019, para medir la precisión diagnóstica del SAPI en una muestra de 240 niños y su reproducibilidad y aplicabilidad en una muestra de 60 niños. Los datos fueron procesados y analizados en MedCalc y VassarStats.net. Resultados En el punto de corte ≥ 3, el puntaje presentó una sensibilidad del 73,6 %, especificidad del 95,7 %, valor predictivo positivo del 83 %, valor predictivo negativo de 92,7, área bajo la curva ROC del 93,6 %, prevalencia estimada por la prueba del 19,6 %, razón de probabilidad positiva 17,1, probabilidad posprueba positiva del 77,8 %, kappa simple de 0,946. Conclusión El estudio presenta evidencias sobre la elevada precisión, utilidad y reproducibilidad del SAPI en la identificación del deterioro clínico en un escenario hospitalario pediátrico brasileño, por lo que el instrumento se consideró aplicable en el contexto de la investigación. (SAPI hospitalizados prospectiva 201 2019 24 6 VassarStatsnet VassarStats net VassarStats.net 3 736 73 73, % 957 95 7 95, 8 927 92 92,7 936 93 93, 196 19 19, 171 17 1 17,1 778 77 77, 0946 0 946 0,946 brasileño investigación 20 2 9 92, 17, 094 94 0,94 09 0,9 0,

Abstract Objective To assess the Pediatric Alert Score (EPA) accuracy, usefulness, reproducibility and applicability in identifying clinical deterioration in hospitalized children and adolescents. Methods This is a prospective diagnostic test study, carried out between October/2018 and October/2019, to measure EPA diagnostic accuracy in a sample of 240 children, and its reproducibility and applicability in a sample of 60 children. Data were processed and analyzed on MedCalc and VassarStats.net. Results At cut-off point ≥ 3, the score had a sensitivity of 73.6%, specificity of 95.7%, positive predictive value of 83%, negative predictive value of 92.7, area under the ROC curve of 93.6%, estimated prevalence of 19.6%, positive probability ratio of 17.1, positive post-test probability of 77.8%, simple Kappa of 0.946. Conclusion The study provides evidence on EPA high accuracy, usefulness and reproducibility in identifying clinical deterioration in a Brazilian pediatric hospital setting, and considered the instrument applicable in the context of the research. (EPA adolescents October2018 October 2018 October/201 October2019 2019 October/2019 24 6 VassarStatsnet VassarStats net VassarStats.net cutoff cut off 3 736 73 73.6% 957 95 7 95.7% 83 83% 927 92 92.7 936 93 93.6% 196 19 19.6% 171 17 1 17.1 posttest post 778 77 8 77.8% 0946 0 946 0.946 setting research October201 201 October/20 2 73.6 9 95.7 92. 93.6 19.6 17. 77.8 094 94 0.94 October20 20 October/2 73. 95. 93. 19. 77. 09 0.9 October2 October/ 0.

Resumo Objetivo Avaliar a acurácia, utilidade, reprodutibilidade e aplicabilidade do Escore Pediátrico de Alerta (EPA) na identificação da deterioração clínica em crianças e adolescentes hospitalizados. Métodos Estudo de teste diagnóstico, prospectivo, realizado entre outubro/2018 a outubro/2019, para medir a acurácia diagnóstica do EPA em uma amostra de 240 crianças, e sua reprodutibilidade e aplicabilidade em uma amostra de 60 crianças. Os dados foram processados e analisados no MedCalc e VassarStats.net. Resultados No ponto de corte ≥ 3, o escore apresentou sensibilidade de 73,6%, especificidade de 95,7%, valor preditivo positivo de 83%, valor preditivo negativo de 92,7, área sob a curva ROC de 93,6%, prevalência estimada pelo teste de 19,6%, razão de probabilidade positiva 17,1, probabilidade pós-teste positivo de 77,8%, kappa simples de 0,946. Conclusão O estudo fornece evidências sobre a elevada acurácia, utilidade e reprodutibilidade do EPA na identificação da deterioração clínica em um cenário hospitalar pediátrico brasileiro, e considerou o instrumento aplicável no contexto da pesquisa. (EPA hospitalizados diagnóstico prospectivo outubro2018 outubro 2018 outubro/201 outubro2019 2019 outubro/2019 24 6 VassarStatsnet VassarStats net VassarStats.net 3 736 73 73,6% 957 95 7 95,7% 83 83% 927 92 92,7 936 93 93,6% 196 19 19,6% 171 17 1 17,1 pósteste pós 778 77 8 77,8% 0946 0 946 0,946 brasileiro pesquisa outubro201 201 outubro/20 2 73,6 9 95,7 92, 93,6 19,6 17, 77,8 094 94 0,94 outubro20 20 outubro/2 73, 95, 93, 19, 77, 09 0,9 outubro2 outubro/ 0,

Resumen Objetivo Caracterizar la competencia digital y el aprendizaje de estudiantes de enfermería sobre la historia de las asociaciones profesionales en la enfermería brasileña. Métodos Estudio exploratorio descriptivo, transversal, realizado en la carrera de licenciatura en enfermería, en tres campi de una institución de enseñanza superior pública federal del nordeste brasileño. De noviembre de 2020 a mayo de 2021, se aplicó un cuestionario por Google Forms a los estudiantes de enfermería regularmente matriculados en el segundo y tercer semestre de la carrera. Se realizó un análisis estadístico descriptivo e inferencial. Resultados Participaron 56 estudiantes de enfermería, el 55,4 % estaba vinculado al campus 1; el 53,6 % del tercer semestre; el 83,9 % de sexo femenino; promedio de edad de 20,55 (+3,32) años; el 55,4 % pardo; el 94,6 % sin vínculo laboral; el 73,2 % vive con sus padres; el 92,9 % con ingresos familiares mensuales equivalentes a tres salarios mínimos. El nivel de competencia digital básica promedio fue considerado bajo. En lo que se refiere a las tecnologías digitales en la enseñanza y al aprendizaje sobre historia de las asociaciones profesionales, el 62,5 % consideró que contribuiría para el aprendizaje, más allá del aula, y facilitaría el acceso a los contenidos; el 78,6 % lo consideró importante para desarrollar el sentido crítico-reflexivo y para concientizar sobre la participación en esas asociaciones. Consideraron fundamental conocer la historia de la creación, las contribuciones, las luchas, los desafíos y las primeras directoras de la Asociación Brasileña de Enfermería, además de la creación del Consejo Federal y los Consejos Regionales de Enfermería y sus respectivas atribuciones. Conclusión Las acciones de enseñanza-aprendizaje, mediadas por tecnologías digitales, deben considerar las competencias digitales y los intereses de los estudiantes en el aprendizaje remoto sobre historia de las asociaciones profesionales de enfermería. brasileña transversal brasileño 202 2021 inferencial 5 554 55 4 55, 1 536 53 6 53, 839 83 9 83, femenino 2055 20 20,5 +3,32 332 3 32 (+3,32 años pardo 946 94 94, laboral 732 73 2 73, padres 929 92 92, mínimos bajo 625 62 62, aula contenidos 786 78 78, críticoreflexivo crítico reflexivo contribuciones luchas atribuciones enseñanzaaprendizaje, enseñanzaaprendizaje enseñanza-aprendizaje 8 205 20, +3,3 33 (+3,3 7 +3, (+3, +3 (+3 + (+ (

Abstract Objective To characterize the digital proficiency of nurse students about the history of Brazilian nursing class institutions. Methods Exploratory-descriptive, cross-sectional study carried out in the Nursing bachelor’s degree from three campuses of a federal public higher education institution in northeastern Brazil. We applied, from November 2020 to May, a questionnaire via Google Forms to nurse students regularly registered in the second and third periods of the course. We carried out statistical, descriptive, and inferential analyses. Results 56 nurse students participated in the study, of which 55.64% were from campus 1; 53.6% attended the third semester, 83.9% were female; average age of 20.55 (+3.32) years old; 55.4 were brown; 94.6% with no employment relationship; 73.2% living with their parents; 92.9% with a monthly family income of three minimum wages. We considered the average degree of basic digital proficiency low. Regarding the digital technologies in teaching and the learning about the class institutions’ history, 62.5% believed that it contributed to the learning process, besides the classroom space and it eased the access to content, and 78.6% considered it important to develop a critical-reflexive sense and the awareness about the participation of these institutions. They found it fundamental to know the creation history, contributions, struggles, challenges, and first directors of the Brazilian Nursing Association, besides the creation of the Nursing Federal and Regional Councils and the respective attributions. Conclusion The teaching-learning process mediated by digital technologies needs to consider the digital competencies and students’ interest in remote teaching about the nursing class institutions’ history. institutions Exploratorydescriptive, Exploratorydescriptive Exploratory descriptive Exploratory-descriptive crosssectional cross sectional bachelors bachelor s Brazil applied 202 May course statistical analyses 5 5564 55 64 55.64 1 536 53 6 53.6 semester 839 83 9 83.9 female 2055 20 20.5 +3.32 332 3 32 (+3.32 old 554 4 55. brown 946 94 94.6 relationship 732 73 2 73.2 parents 929 92 92.9 wages low 625 62 62.5 content 786 78 78.6 criticalreflexive critical reflexive contributions struggles challenges Association attributions teachinglearning 556 55.6 53. 8 83. 205 20. +3.3 33 (+3.3 94. 7 73. 92. 62. 78. +3. (+3. +3 (+3 + (+ (

Resumo Objetivo Caracterizar a proficiência digital e a aprendizagem de estudantes de enfermagem sobre a história das entidades de classe da enfermagem brasileira. Métodos Estudo exploratório-descritivo, transversal, realizado no curso de bacharelado em enfermagem, de três campi de uma instituição de ensino superior pública federal do Nordeste brasileiro. Aplicou-se, de novembro de 2020 a maio de 2021, questionário, via Google Forms, aos estudantes de enfermagem regularmente matriculados no segundo e terceiro períodos do curso. Realizou-se a análise estatística descritiva e inferencial. Resultados Participaram 56 estudantes de enfermagem, sendo 55,4% vinculados ao campus 1; 53,6% cursavam o terceiro semestre; 83,9% do sexo feminino; média idade de 20,55 (+3,32) anos; 55,4% pardos; 94,6% sem vínculo empregatício; 73,2% residindo com os pais; 92,9% com renda familiar mensal equivalente a três salários-mínimos. O grau de proficiência digital básico médio foi considerado baixo. Quanto às tecnologias digitais no ensino e à aprendizagem sobre história das entidades de classe, 62,5% acreditaram que contribuiria para aprendizagem, além do espaço da sala de aula, e facilitaria o acesso aos conteúdos; e 78,6% consideraram importante para desenvolver o senso crítico-reflexivo e a conscientização sobre a participação nessas entidades. Evidenciaram fundamental conhecer história da criação, contribuições, lutas, desafios e primeiras diretoras da Associação Brasileira de Enfermagem, além da criação dos Conselhos Federal e Regionais de Enfermagem e das respectivas atribuições. Conclusão As ações de ensino-aprendizagem, mediadas por tecnologias digitais, precisam considerar as competências digitais e os interesses dos estudantes na aprendizagem remota sobre história das entidades de classe da enfermagem. brasileira exploratóriodescritivo, exploratóriodescritivo exploratório descritivo, descritivo exploratório-descritivo transversal brasileiro Aplicouse, Aplicouse Aplicou se, se Aplicou-se 202 2021 questionário Forms Realizouse Realizou inferencial 5 554 55 4 55,4 1 536 53 6 53,6 semestre 839 83 9 83,9 feminino 2055 20 20,5 +3,32 332 3 32 (+3,32 anos pardos 946 94 94,6 empregatício 732 73 2 73,2 pais 929 92 92,9 saláriosmínimos. saláriosmínimos salários mínimos. mínimos salários-mínimos baixo 625 62 62,5 aula conteúdos 786 78 78,6 críticoreflexivo crítico reflexivo contribuições lutas atribuições ensinoaprendizagem, ensinoaprendizagem ensino-aprendizagem 55, 53, 8 83, 205 20, +3,3 33 (+3,3 94, 7 73, 92, 62, 78, +3, (+3, +3 (+3 + (+ (

Abstract Colorectal Cancer (CRC) is the third most common type of cancer worldwide and ranks second in mortality. Screening programs for early detection and treatment have been implemented in several countries. Economic evaluations are an important tool to support decision-making about reimbursement and coverage decisions in health systems and, therefore, to support efficient resource allocation. The article aims to review the up-to-date evidence on economic evaluations of CRC screening strategies. MEDLINE, EMBASE, Web of Science, SCOPUS, SciELO, Lilacs, CRD databases, and lists of references were reviewed to identify relevant literature regarding full economic evaluations of CRC screening in asymptomatic average-risk individuals over 40 years old. Searches were conducted with no restriction to language, setting, or date. Qualitative syntheses described CRC screening strategies and comparators (baseline context), study designs, key parameter inputs and incremental cost-effectiveness ratios. Seventy-nine articles were included. Most of the studies were from high-income countries and a third-party payer perspective. Markov models were predominantly used, although microsimulation has been increasingly adopted in the last 15 years. The authors found 88 different screening strategies for CRC, which differed in the type of technique, the interval of screening, and the strategy, i.e., isolated or combined. The annual fecal immunochemical test was the most predominant screening strategy. All studies reported cost-effective results in their scenarios compared to no screening scenarios. One-quarter of the publications reported cost-saving results. It is still necessary to develop future economic evaluations in Low- and Middle-Income Countries (LMICs), which account for the high burden of disease. (CRC mortality decisionmaking decision making therefore allocation uptodate up date MEDLINE EMBASE Science SCOPUS SciELO Lilacs databases averagerisk average risk 4 old language setting baseline context, context , context) designs costeffectiveness cost effectiveness ratios Seventynine Seventy nine included highincome income thirdparty party perspective used 1 8 technique strategy ie i e i.e. combined costeffective effective Onequarter One quarter costsaving saving Low MiddleIncome Middle Income LMICs, LMICs (LMICs) disease i.e (LMICs

Abstract Objective This review synthesized existing studies on the prevalence of chronic pain in Brazil and its associated factors to produce a recent estimation to guide public health politics. Methods A search was carried out in the Ovid Medline, Embase, Web of Science, and BVS Regional/Lilacs databases to identify population-based cross-sectional studies from 2005 to 2020, which reported the prevalence of benign chronic pain in Brazil (more than three months). The risk of bias was assessed using design, sample size determination, and random selection as essential issues. Pooled prevalence estimates were calculated for chronic pain in the general and elderly populations. The protocol was registered on Prospero (CRD42021249678). Results Of the 682 identified, 15 macheted the authors’ inclusion criteria. Chronic pain prevalence in the general adult population ranged from 23.02% to 41.4% (pooled estimate 35.70%, 95% Cis 30.42 to 41.17) and was described as moderate to intense. It was associated with female sex, old age, lower education, intense professional activity, excessive alcohol consumption, smoking, central obesity, mood disorder, and sedentarism. The Southeastern and Southern regions presented a higher prevalence. The prevalence in the elderly population ranged from 29.3% to 76.2% (pooled estimate 47.32%, 95% Cis 33.73 to 61.11). In addition, this population visited doctors more frequently, had more sleep disorders, and was more dependent on daily living activities. Almost fifty percent of both populations with chronic pain reported pain-induced disability. Conclusion Chronic Pain is highly prevalent in Brazil and associated with significant distress, disability, and poorly controlled. politics Medline Embase Science RegionalLilacs Regional Lilacs populationbased based crosssectional cross sectional 200 2020 months. months . months) design determination issues CRD42021249678. CRD42021249678 CRD (CRD42021249678) 68 identified 1 authors criteria 2302 23 02 23.02 414 41 4 41.4 pooled 3570 35 70 35.70% 95 3042 30 42 30.4 41.17 4117 17 sex age education activity consumption smoking obesity disorder sedentarism 293 29 3 29.3 762 76 2 76.2 4732 47 32 47.32% 3373 33 73 33.7 61.11. 6111 61.11 61 11 61.11) addition frequently disorders activities paininduced induced disability distress controlled 20 202 CRD4202124967 (CRD42021249678 6 230 0 23.0 41. 357 7 35.70 9 304 30. 41.1 411 29. 76. 473 47.32 337 33. 611 61.1 CRD420212496 (CRD4202124967 23. 35.7 47.3 61. CRD42021249 (CRD420212496 35. 47. CRD4202124 (CRD42021249 CRD420212 (CRD4202124 CRD42021 (CRD420212 CRD4202 (CRD42021 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

ABSTRACT OBJECTIVE To evaluate the accuracy of yellow fever (YF) suspected case definitions from the Brazilian Ministry of Health (BMH) and World Health Organization (WHO), as well as propose and evaluate new definitions of suspected cases, considering confirmed and discarded cases. METHODS The retrospective study was conducted at the Instituto de Infectologia Emílio Ribas (IIER), using the Epidemiologic Surveillance Form of YF cases. From the confirmed and discarded cases of YF, a logistic regression model was developed. The independent variables were used in a proposed definition of a suspected case of YF and its accuracy was evaluated. RESULTS In total, 113 YF suspect cases were reported, with 78 confirmed (69.0%). The definitions by BMH and WHO presented low sensitivity, 59% and 53.8%, and reduced accuracy, 53.1% and 47.8%, respectively. Predictive factors for YF were thrombocytopenia, leukopenia, and elevation of transaminases greater than twice normal. The definition including individual with acute onset of fever, followed by elevation of ALT or AST greater than twice the reference value AND leukopenia OR thrombocytopenia presented high sensitivity (88.3%), specificity (62.9%), and the best accuracy (80.4%), as proposed in the model. CONCLUSION The YF suspected case definitions of the BMH and the WHO have low sensitivity. The inclusion of nonspecific laboratory tests increases the accuracy of YF definition. (YF (BMH WHO, , (WHO) IIER, IIER (IIER) developed evaluated total 11 reported 7 69.0%. 690 69.0% . 69 0 (69.0%) 59 538 53 8 53.8% 531 1 53.1 478 47 47.8% respectively normal 88.3%, 883 88.3% 88 3 (88.3%) 62.9%, 629 62.9% 62 9 (62.9%) 80.4%, 804 80.4% 80 4 (80.4%) (WHO (IIER 69.0 6 (69.0% 5 53.8 53. 47.8 88.3 (88.3% 62.9 (62.9% 80.4 (80.4% 69. (69.0 47. 88. (88.3 62. (62.9 80. (80.4 (69. (88. (62. (80. (69 (88 (62 (80 (6 (8 (

ABSTRACT OBJECTIVE To evaluate the quality of anthropometric data of children recorded in the Food and Nutrition Surveillance System (SISVAN) from 2008 to 2017. METHOD Descriptive study on the quality of anthropometric data of children under five years of age admitted in primary care services of the Unified Health System, from the individual databases of SISVAN. Data quality was annually assessed using the indicators: coverage, completeness, sex ratio, age distribution, weight and height digit preference, implausible z-score values, standard deviation, and normality of z-scores. RESULTS In total, 73,745,023 records and 29,852,480 children were identified. Coverage increased from 17.7% in 2008 to 45.4% in 2017. Completeness of birth date, weight, and height corresponded to almost 100% in all years. The sex ratio was balanced and approximately similar to the expected ratio, ranging from 0.8 to 1. The age distribution revealed higher percentages of registrations from the ages of two to four years until mid-2015. A preference for terminal digits “zero” and “five” was identified among weight and height records. The percentages of implausible z-scores exceeded 1% for all anthropometric indices, with values decreasing from 2014 onwards. A high dispersion of z-scores, including standard deviations between 1.2 and 1.6, was identified mainly in the indices including height and in the records of children under two years of age and residents in the North, Northeast, and Midwest regions. The distribution of z-scores was symmetric for all indices and platykurtic for height/age and weight/age. CONCLUSIONS The quality of SISVAN anthropometric data for children under five years of age has improved substantially between 2008 and 2017. Some indicators require attention, particularly for height measurements, whose quality was lower especially among groups more vulnerable to nutritional problems. (SISVAN 200 2017 coverage completeness zscore z score deviation zscores. zscores scores. scores total 73745023 73 745 023 73,745,02 29852480 29 852 480 29,852,48 177 17 7 17.7 454 45 4 45.4 date 100 08 0 8 0. 1 mid2015. mid2015 mid 2015. 2015 mid-2015 zero “zero “five 201 onwards zscores, scores, 12 2 16 6 1.6 North Northeast regions heightage weightage weight/age attention measurements problems 20 7374502 74 02 73,745,0 2985248 85 48 29,852,4 17. 45. 10 mid201 mid-201 737450 73,745, 298524 29,852, mid20 mid-20 73745 73,745 29852 29,852 mid2 mid-2 7374 73,74 2985 29,85 mid- 737 73,7 298 29,8 73, 29,

RESUMO OBJETIVOS Avaliar a qualidade dos dados antropométricos de crianças registradas no Sistema de Vigilância Alimentar e Nutricional (Sisvan) no período 2008-2017. MÉTODOS Estudo descritivo sobre a qualidade dos dados antropométricos de crianças menores de 5 anos atendidas nos serviços de atenção primária do Sistema Único de Saúde, a partir das bases de dados individuais do Sisvan. A qualidade dos dados foi avaliada anualmente por meio dos indicadores: cobertura, completude, razão entre sexos, distribuição da idade, preferência por dígitos de peso e estatura, valores de escore-z implausíveis, desvio-padrão e normalidade dos escores-z. RESULTADOS No total, 73.745.023 registros e 29.852.480 crianças foram identificados. A cobertura aumentou de 17,7% em 2008 para 45,4% em 2017. A completude da data de nascimento, peso e estatura correspondeu a quase 100% para todos os anos. A razão entre sexos foi equilibrada e aproximadamente similar a razão esperada, variando entre 0,8 e 1. A distribuição da idade revelou maiores percentuais de registros entre as idades de 2 a 4 anos até meados de 2015. Uma preferência pelos dígitos terminais “zero” e “cinco” foi identificada entre os registros de peso e estatura. As porcentagens de escores-z implausíveis excederam 1% para todos os índices antropométricos, com redução dos valores a partir de 2014. Uma alta dispersão dos escores-z, incluindo desvios-padrão entre 1,2 e 1,6, foi identificada principalmente nos índices incluindo estatura e nos registros de crianças menores de 2 anos e residentes das regiões Norte, Nordeste e Centro-Oeste. A distribuição dos escores-z foi simétrica para todos os índices e platicúrtica para estatura/idade e peso/idade. CONCLUSÕES A qualidade dos dados antropométricos do Sisvan para crianças menores de 5 anos melhorou substancialmente entre 2008 e 2017. Alguns indicadores requerem atenção, sobretudo para medidas de estatura, cuja qualidade foi principalmente inferior entre os grupos mais vulneráveis a agravos nutricionais. (Sisvan 20082017. 20082017 2017 2008-2017 Saúde escorez escore z desviopadrão desvio padrão escoresz. escoresz escores z. total 73745023 73 745 023 73.745.02 29852480 29 852 480 29.852.48 identificados 177 17 7 17,7 200 454 45 45,4 nascimento 100 esperada 08 0 8 0, 1 2015 zero “zero cinco “cinco 2014 escoresz, z, desviospadrão desvios 12 1, 16 6 1,6 Norte CentroOeste. CentroOeste Centro Oeste. Oeste Centro-Oeste estaturaidade pesoidade peso/idade nutricionais 2008201 201 2008-201 7374502 74 02 73.745.0 2985248 85 48 29.852.4 17, 20 45, 10 200820 2008-20 737450 73.745. 298524 29.852. 20082 2008-2 73745 73.745 29852 29.852 2008- 7374 73.74 2985 29.85 737 73.7 298 29.8 73. 29.

ABSTRACT Background: Women living with human immunodeficiency virus (HIV) (WLWH) are more likely to be infected with the oncogenic human papillomavirus (HPV). We assessed the prevalence of high-risk (HR) (16/18/31/33/35/39/45/51/52/56/58/59/68/73/82), probable high-risk (pHR) (26/53/66), and low-risk (LR) (6/11/40/42/43/44/54/61/70) HPV types and their associated risk factors. Methods: This cross-sectional study of WLWH aged 18-64 years included one laboratory and eight HIV-specialty healthcare facilities in the pilot network. Descriptive statistics were used to assess sociodemographic and behavioral characteristics. Adjusted analyses were conducted to evaluate risk factors associated with HR and/or pHR HPV infection in WLWH. Results: From May/2021 to May/2022, 1,914 (92.5%) WLWH participated in the pilot study and had valid HPV-DNA results of self-collected vaginal samples. The median age of the participants was 45 years, 60.1% had ≥ 9 years of schooling, 80.5% were ≤ 18 years at first sexual intercourse, and 51.7% had > 4 sexual partners throughout life. The prevalence of any HPV type, HR HPV, pHR HPV, and LR HPV was 65.8%, 49.6%, 16.7%, and 40.0%, respectively. Age was inversely associated with pHR and/or HR-HPV (p < 0.001), and education level was inversely associated with HR-HPV (p = 0.003) types. Any HR or pHR was associated with being single (p = 0.029) and exchanging sex for drugs (p = 0.037). Conclusions: The prevalence of HPV, especially HR HPV, among WLWH is high in Brazil, highlighting the need for HPV screening in this population. Self-collection of vaginal samples is an important strategy for increasing testing access. Background HIV (HIV (WLWH HPV. . (HPV) highrisk (HR 16/18/31/33/35/39/45/51/52/56/58/59/68/73/82, 161831333539455152565859687382 16/18/31/33/35/39/45/51/52/56/58/59/68/73/82 , 16 31 33 35 39 51 52 56 58 59 68 73 82 (16/18/31/33/35/39/45/51/52/56/58/59/68/73/82) (pHR 26/53/66, 265366 26/53/66 26 53 66 (26/53/66) lowrisk low (LR 6/11/40/42/43/44/54/61/70 61140424344546170 6 11 40 42 43 44 54 61 70 (6/11/40/42/43/44/54/61/70 Methods crosssectional cross sectional 1864 64 18-6 HIVspecialty specialty network characteristics andor Results May2021 May 2021 May/202 May2022 2022 May/2022 1914 1 914 1,91 92.5% 925 92 5 (92.5% HPVDNA DNA selfcollected self collected 601 60 60.1 schooling 805 80 80.5 intercourse 517 7 51.7 life type 658 65 8 65.8% 496 49 49.6% 167 16.7% 400 0 40.0% respectively HRHPV p 0.001, 0001 0.001 001 0.001) 0.003 0003 003 0.029 0029 029 0.037. 0037 0.037 037 0.037) Conclusions Brazil population Selfcollection Self collection access (HPV 16183133353945515256585968738 16/18/31/33/35/39/45/51/52/56/58/59/68/73/8 3 (16/18/31/33/35/39/45/51/52/56/58/59/68/73/82 26536 26/53/6 2 (26/53/66 6/11/40/42/43/44/54/61/7 6114042434454617 (6/11/40/42/43/44/54/61/7 186 18- May202 202 May/20 191 91 1,9 92.5 (92.5 60. 80. 51. 65.8 49.6 16.7 40.0 000 0.00 00 0.02 002 02 0.03 03 1618313335394551525658596873 16/18/31/33/35/39/45/51/52/56/58/59/68/73/ (16/18/31/33/35/39/45/51/52/56/58/59/68/73/8 2653 26/53/ (26/53/6 6/11/40/42/43/44/54/61/ 611404243445461 (6/11/40/42/43/44/54/61/ May20 20 May/2 19 1, 92. (92. 65. 49. 16. 40. 0.0 161831333539455152565859687 16/18/31/33/35/39/45/51/52/56/58/59/68/73 (16/18/31/33/35/39/45/51/52/56/58/59/68/73/ 265 26/53 (26/53/ 6/11/40/42/43/44/54/61 61140424344546 (6/11/40/42/43/44/54/61 May2 May/ (92 0. 16183133353945515256585968 16/18/31/33/35/39/45/51/52/56/58/59/68/7 (16/18/31/33/35/39/45/51/52/56/58/59/68/73 26/5 (26/53 6/11/40/42/43/44/54/6 6114042434454 (6/11/40/42/43/44/54/6 (9 1618313335394551525658596 16/18/31/33/35/39/45/51/52/56/58/59/68/ (16/18/31/33/35/39/45/51/52/56/58/59/68/7 26/ (26/5 6/11/40/42/43/44/54/ 611404243445 (6/11/40/42/43/44/54/ ( 161831333539455152565859 16/18/31/33/35/39/45/51/52/56/58/59/68 (16/18/31/33/35/39/45/51/52/56/58/59/68/ (26/ 6/11/40/42/43/44/54 61140424344 (6/11/40/42/43/44/54 16183133353945515256585 16/18/31/33/35/39/45/51/52/56/58/59/6 (16/18/31/33/35/39/45/51/52/56/58/59/68 (26 6/11/40/42/43/44/5 6114042434 (6/11/40/42/43/44/5 1618313335394551525658 16/18/31/33/35/39/45/51/52/56/58/59/ (16/18/31/33/35/39/45/51/52/56/58/59/6 (2 6/11/40/42/43/44/ 611404243 (6/11/40/42/43/44/ 161831333539455152565 16/18/31/33/35/39/45/51/52/56/58/59 (16/18/31/33/35/39/45/51/52/56/58/59/ 6/11/40/42/43/44 61140424 (6/11/40/42/43/44 16183133353945515256 16/18/31/33/35/39/45/51/52/56/58/5 (16/18/31/33/35/39/45/51/52/56/58/59 6/11/40/42/43/4 6114042 (6/11/40/42/43/4 1618313335394551525 16/18/31/33/35/39/45/51/52/56/58/ (16/18/31/33/35/39/45/51/52/56/58/5 6/11/40/42/43/ 611404 (6/11/40/42/43/ 161831333539455152 16/18/31/33/35/39/45/51/52/56/58 (16/18/31/33/35/39/45/51/52/56/58/ 6/11/40/42/43 61140 (6/11/40/42/43 16183133353945515 16/18/31/33/35/39/45/51/52/56/5 (16/18/31/33/35/39/45/51/52/56/58 6/11/40/42/4 6114 (6/11/40/42/4 1618313335394551 16/18/31/33/35/39/45/51/52/56/ (16/18/31/33/35/39/45/51/52/56/5 6/11/40/42/ 611 (6/11/40/42/ 161831333539455 16/18/31/33/35/39/45/51/52/56 (16/18/31/33/35/39/45/51/52/56/ 6/11/40/42 (6/11/40/42 16183133353945 16/18/31/33/35/39/45/51/52/5 (16/18/31/33/35/39/45/51/52/56 6/11/40/4 (6/11/40/4 1618313335394 16/18/31/33/35/39/45/51/52/ (16/18/31/33/35/39/45/51/52/5 6/11/40/ (6/11/40/ 161831333539 16/18/31/33/35/39/45/51/52 (16/18/31/33/35/39/45/51/52/ 6/11/40 (6/11/40 16183133353 16/18/31/33/35/39/45/51/5 (16/18/31/33/35/39/45/51/52 6/11/4 (6/11/4 1618313335 16/18/31/33/35/39/45/51/ (16/18/31/33/35/39/45/51/5 6/11/ (6/11/ 161831333 16/18/31/33/35/39/45/51 (16/18/31/33/35/39/45/51/ 6/11 (6/11 16183133 16/18/31/33/35/39/45/5 (16/18/31/33/35/39/45/51 6/1 (6/1 1618313 16/18/31/33/35/39/45/ (16/18/31/33/35/39/45/5 6/ (6/ 161831 16/18/31/33/35/39/45 (16/18/31/33/35/39/45/ (6 16183 16/18/31/33/35/39/4 (16/18/31/33/35/39/45 1618 16/18/31/33/35/39/ (16/18/31/33/35/39/4 161 16/18/31/33/35/39 (16/18/31/33/35/39/ 16/18/31/33/35/3 (16/18/31/33/35/39 16/18/31/33/35/ (16/18/31/33/35/3 16/18/31/33/35 (16/18/31/33/35/ 16/18/31/33/3 (16/18/31/33/35 16/18/31/33/ (16/18/31/33/3 16/18/31/33 (16/18/31/33/ 16/18/31/3 (16/18/31/33 16/18/31/ (16/18/31/3 16/18/31 (16/18/31/ 16/18/3 (16/18/31 16/18/ (16/18/3 16/18 (16/18/ 16/1 (16/18 16/ (16/1 (16/ (16 (1

Resumen Objetivo Traducir, adaptar culturalmente y validar el contenido de la Preterm Infant Breastfeeding Behaviour Scale (PIBBS). Métodos Estudio metodológico, cuyas etapas fueron: traducción inicial, síntesis de las traducciones, retrotraducción, revisión de las versiones traducidas, validación de contenido, prueba piloto y envío de la documentación al Comité de Revisión de Adaptación Transcultural. Tanto la escala original, como la traducida y adaptada, contienen seis ítems y cada uno contiene de tres a seis subítems con puntuación que varía de 0 a 6. La puntuación total puede variar de 0 a 20. Para la etapa de validación se realizó el cálculo de índice de validez de contenido (IVC) de todos los ítems de la escala. Se consideró IVC mínimo de 0,8 como aceptable para la evaluación de cada ítem individualmente, y de 0,90 para la evaluación general del instrumento. Resultados La versión brasileña de la escala PIBBS fue denominada “Escala Comportamental de amamentação do pré-termo” (Escala de Comportamiento de Lactancia del Recién Nacido Prematuro). La escala fue traducida y adaptada, y su contenido fue validado, con una equivalencia conceptual e idiomática que varió de 83,3 % a 100 %. El índice de validez de contenido fue de 0,93. Conclusión Después de su traducción, adaptación y validación por parte de los profesionales de la salud, la escala demostró ser válida, de fácil aplicación y con un lenguaje de fácil comprensión. La escala permitirá que los profesionales de la salud puedan observar el comportamiento del prematuro y orientar a la madre, con el objetivo de estimular la lactancia materna exclusiva, ya que el proceso de lactancia del prematuro es complejo. Su uso en investigaciones futuras y en la práctica clínica permitirá complementar análisis psicométricos más sólidos. Traducir PIBBS. . (PIBBS) metodológico fueron inicial traducciones retrotraducción traducidas Transcultural original adaptada 6 20 (IVC 08 8 0, individualmente 090 90 0,9 instrumento Escala prétermo pré termo pré-termo Prematuro. Prematuro Prematuro) validado 833 83 3 83, 10 093 93 0,93 válida comprensión madre exclusiva complejo sólidos (PIBBS 2 09 9 1

Abstract Objective To translate, culturally adapt and validate the Preterm Infant Breastfeeding Behavior Scale (PIBBS) content Methods This is a methodological study, whose steps were: initial translation; synthesis of translations; back-translation; review of translated versions; content validity; pre-test; and sending the documentation to the Cross-Cultural Adaptation Review Committee. Both the original scale and the translated and adapted scale have six items, and each item contains 03 to 06 sub-items with score scores ranging from 0 to 6. The total score can range from 0 to 20. For the validity step, the Content Validity Index (CVI) of all scale items was calculated. A minimum CVI of 0.8 was considered acceptable for assessing each item individually, and 0.90, for generally assessing the instrument. Results The Brazilian version of PIBBS was called the “Escala Comportamental de Amamentação do Pré-Termo”. The scale was translated, adapted and its content was validated, achieving conceptual and idiomatic equivalence ranging from 83.3% to 100%. The CVI was 0.93. Conclusion After translation, adaptation and validity by health professionals, the scale proved to be valid, easy to apply and easy to understand language. The scale will allow health professionals to observe preterm infants’ behavior and guide mothers, thus encouraging exclusive breastfeeding, since the breastfeeding process of a preterm infant is complex. Its use in future research and clinical practice will complement more robust psychometric analyses. translate (PIBBS study were translation translations backtranslation back back-translation versions pretest pre test pre-test CrossCultural Cross Cultural Committee subitems sub 6 20 step (CVI calculated 08 8 0. individually 090 90 0.90 instrument Escala PréTermo. PréTermo Pré Termo . Pré-Termo” validated 833 83 3 83.3 100 100% 093 93 0.93 valid language infants mothers complex analyses 2 09 9 0.9 Pré-Termo 83. 10 1

Resumo Objetivo Traduzir, adaptar culturalmente e validar o conteúdo da Preterm Infant Breastfeeding Behaviour Scale (PIBBS) Métodos Estudo metodológico, cujas etapas foram: tradução inicial; síntese das traduções; retrotradução; revisão das versões traduzidas; validação do conteúdo; pré-teste; e encaminhamento da documentação ao Comitê de Revisão da Adaptação Transcultural. Tanto a escala original quanto a traduzida e adaptada possuem seis itens e cada item contém 03 a 06 subitens com escores de pontuação que variam de 0 a 6. A pontuação total pode variar de 0 a 20. Para a etapa de validação foi realizado o cálculo do índice de validade de conteúdo (IVC) de todos os itens da escala. Foi considerado IVC mínimo de 0,8 como aceitável, para avaliação de cada item individualmente; e de 0,90, para avaliação geral do instrumento. Resultados A versão brasileira da escala PIBBS foi denominada de Escala Comportamental de amamentação do pré-termo. A escala foi traduzida, adaptada e seu conteúdo foi validado, alcançando equivalência conceitual e idiomática que variou de 83,3% a 100%. O índice de validade de conteúdo foi de 0,93. Conclusão Após a tradução, adaptação e validação pelos profissionais de saúde a escala se mostrou válida, de fácil aplicação e linguagem de fácil entendimento. A escala permitirá que os profissionais de saúde possam observar o comportamento do prematuro e orientar a mãe, estimulando assim o aleitamento materno exclusivo, já que o processo de amamentação do prematuro é complexo. Sua utilização em pesquisas futuras e prática clínica permitirá complementar as análises psicométricas mais robustas. Traduzir (PIBBS metodológico foram inicial traduções retrotradução traduzidas préteste pré teste pré-teste Transcultural 6 20 (IVC 08 8 0, aceitável individualmente 090 90 0,90 instrumento prétermo. prétermo termo. termo pré-termo validado 833 83 3 83,3 100 100% 093 93 0,93 válida entendimento mãe exclusivo complexo robustas 2 09 9 0,9 83, 10 1

ABSTRACT Objective To analyze the karyotype test and myeloid panel with next-generation sequencing findings in patients with myelofibrosis, and to compare transplant characteristics in patients referred for bone marrow transplantation. Methods Retrospective, single-center study with patients diagnosed with myelofibrosis treated at Hospital Israelita Albert Einstein between 2010 and 2020. Results A total of 104 patients with myelofibrosis were examined. Patients who had not been submitted to tests in our service were excluded. The final sample comprised 69 patients. Of these 69, 56 were submitted to karyotyping and 22 to myeloid panel with next-generation sequencing. Karyotype was normal in 60% of the patients and altered in 40%. The prevalence of high-risk molecular mutations was higher in patients referred for bone marrow transplantation (100% versus 50%). The median follow-up of transplant patients was 2.4 years and the overall survival at 2 years was 80% (95%CI: 62-100%). Conclusion The molecular analysis enables estimating the patient’s risk and thus instituting more aggressive treatment such as bone marrow transplant for patients at higher risk, being a relevant tool to guide therapy. Given the significance of molecular analysis for therapeutic decision-making in myelofibrosis, collection and disclosure of data on the prevalence of cytogenetic changes and findings of next-generation sequencing in affected patients is important. nextgeneration next generation Retrospective singlecenter single center 201 2020 10 examined excluded 6 5 60 40 40% highrisk high 100% 100 (100 50%. 50 50% . 50%) followup follow up 24 4 2. 80 95%CI 95CI CI 95 (95%CI 62100%. 62100 62 62-100%) patient s therapy decisionmaking decision making important 20 202 1 (10 8 9 62100% 6210 62-100% (1 621 62-100 ( 62-10 62-1 62-