Resumen El uso de mezclas asfálticas en frío ha despertado el interés en los últimos años debido a que es una técnica que reduce el uso de combustibles y con ello, la huella de carbono en la construcción y mantenimiento de pavimentos, sin embargo, se ha limitado su uso en aplicaciones de bacheo y pavimentos de bajo tránsito, debido a que estas mezclas presentan baja resistencia a edad temprana y altas cantidades de vacíos. El objetivo de la presente investigación fue el desarrollo de una mezcla fría con sustitución del relleno mineral por rellenos cementantes ternarios que en conjunto forman productos de hidratación y brindan mayor resistencia en presencia de agua. Los rellenos cementantes ternarios están compuestos por escoria de alto horno granulada (EGAH), ceniza volante (CV) y un activador alcalino, ya sea cemento Portland (CP) o hidróxido de calcio (cal). A fin de comparar cuál de estos activadores brinda un mayor desempeño se prepararon distintas mezclas con sustitución parcial y total, para evaluar en tres condiciones de curado y observar el comportamiento de las mezclas en presencia de agua. Se comprobó que la sustitución con ambos tipos de rellenos cementantes reduce significativamente los efectos de la humedad a edad temprana. Para la condición de curado de 3 días a 25 °C, la muestra de referencia obtuvo una pérdida de estabilidad de 30,78 %, las muestras con CP de 7,61 y 7,56 %, y las de cal con 13,83 y 16,39 %, por lo que se observa que tienen una menor pérdida de estabilidad en todos los casos, este mismo patrón se mantiene en el tiempo.

Abstract The use of cold asphalt mixtures has aroused interest in recent years because it is a technique that reduces the use of fuels and thus the carbon footprint in the construction and maintenance of pavements, however its use has been limited in patching applications and low-traffic pavements, however, these mixtures have low resistance at an early age and high amounts of voids. The objective of this research was the development of a cold mixture with replacement of the mineral filler with ternary cementitious fillers that together form hydration products and provide greater resistance in the presence of water. The ternary cementitious fillers are composed of granulated blast furnace slag (EGAH), fly ash (CV) and an alkaline activator, Portland cement (CP) or calcium hydroxide (lime), in order to compare which of these activators provides greater performance different mixtures were prepared with partial and total substitution, to evaluate in three curing conditions and observe the behavior of the mixtures in the presence of water. It was proven that replacement with both types of cementitious fillers significantly reduces the effects of moisture at an early age. For the curing condition of 3 days at 25 °C, the reference sample obtained a loss of stability of 30,78 %, the samples with CP of 7,61 and 7,56 %, and those of lime with 13,83 and 16,39 %, have a lower loss of stability in all cases, this same pattern is maintained over time.

Resumo Os autores apresentam um caso atípico de fratura complexa do cotovelo esquerdo com perda extensa de tecido ósseo e muscular. O paciente foi submetido a diversos procedimentos cirúrgicos, que resultaram em uma artroplastia total do cotovelo esquerdo associada à reconstrução do tríceps com enxerto do tendão do músculo semitendíneo. muscular cirúrgicos semitendíneo

Abstract The authors present an atypical case of a left elbow complex fracture with extensive loss of bone and muscle tissue. The patient was submitted to several surgical procedures, which resulted in a total arthroplasty of the left elbow with triceps reconstruction using a semitendinosus muscle tendon graft. tissue procedures graft

Abstract Periapical lesions (PL) of endodontic origin are one of the most common pathological conditions that affect peri-radicular tissues. The main objective of this study was to evaluate the amount and species of microorganisms isolated from necrotic pulps, establish a correlation between these and the size of periapical lesions, and how the amount and species of microorganisms decreased with non-surgical root canal treatment. Twenty-seven patients with a clinical diagnosis of dental pulp necrosis and chronic periapical lesions were selected; a Cone Beam Computed Tomography (CBCT) and microbial samples of the root canal system were taken previous to a disinfection protocol, a post-instrumentation/ disinfection protocol, and a post-medication placement. Samples were processed for colony-forming unit (CFU) counting, Gram staining technique, and bacterial identification by the API-20 Strep/API-20A system. The API system identified 21 species of microorganisms in the pre-instrumentation samples, 11 species in the post-instrumentation samples, and 11 in the post-medication samples. There was a correlation coefficient of 0.598% between the initial size of the lesion and the number of bacteria, with a coefficient of determination up to 35.7%, a correlation coefficient of 0.486% and a determination coefficient of 23.6% between the size of the periapical lesion and the number of CFUs. This study contributes to the knowledge of the amount and species of microorganisms isolated and identified from necrotic pulps, establishes a correlation between the amount and species of microorganisms and the size of the periapical lesions, and shows how the decrease of microorganisms contributes to the healing of PL, corroborating the importance of an adequate disinfection protocol.

Resumen Las lesiones periapicales (LP) de origen endodóncico son la condición patológica más común que afectan los tejidos perirradiculares. El objetivo principal de este estudio es evaluar la cantidad y especie de bacterias aisladas de pulpas necróticas, correlacionar la cantidad y especies bacterianas con el tamaño de la lesión, y cómo disminuyen la cantidad y especies de microorganismos con el tratamiento de conductos. A 27 pacientes con diagnóstico de necrosis pulpar y lesión periapical crónica detectada con CBCT se les tomaron muestras microbianas del sistema de conductos antes y después del protocolo de desinfección y de la medicación intraconducto. Las muestras se procesaron para el recuento de unidades de formación de colonias (UFC), tinción de Gram e identificación mediante el sistema API-20 Strep/API-20A. Se identificaron 21 especies en las muestras pre-instrumentación, 11 en las muestras post-instrumentación y 11 en las muestras post-medicación; se observó un coeficiente de correlación del 0,598% entre el tamaño inicial de la lesión y la cantidad de bacterias, con un coeficiente de determinación hasta el 35,7%, un coeficiente de correlación del 0,486% y un coeficiente de determinación del 23,6% entre el tamaño de la lesión periapical y el número de UFCs. Este estudio contribuye al conocimiento sobre la cantidad y especies de microorganismos aislados e identificados a partir de pulpas necróticas, establece una correlación entre la cantidad y especies de microorganismos y el tamaño de las lesiones periapicales y exhibe cómo la disminución de microorganismos contribuye a la curación de LP, corroborando la importancia de un adecuado protocolo de desinfección.

Resumo Neste trabalho é apresentado um estudo sobre a ruptura do concreto por pry-out em conectores de cisalhamento tipo Crestbond com o objetivo de obter um modelo de cálculo que estima a resistência da conexão a esse modo de falha. As análises foram realizadas por meio de simulações numéricas capazes de reproduzir o referido modo de falha. Os resultados numéricos são comparados com os experimentais e discutidos em relação à força máxima atingida e o aspecto da fissuração típica do pry-out. O modelo de cálculo proposto apresentou boa correspondência com os resultados experimentais, com uma razão média Pteo/Pexp igual a 0,99 e um coeficiente de variação de 10%. Os valores encontrados nesse estudo sugerem que a expressão da Aprovação Técnica Alemã para outros conectores pode ser aplicada nos conectores Crestbond.

Abstract In this work, a study on failure by concrete pry-out in Crestbond shear connectors is presented. The study’s aim was the development of an expression that estimates the connection’s bearing capacity. The analyses were carried out through numerical simulations designed to reproduce the referred failure mode. Numerical and experimental results are compared and discussed in relation to the maximum force reached and the cracking aspect typical of concrete pry-out. The proposed equation corresponded well to experimental results, with a mean ratio Ptheo/Pexp equal to 0,99 and a coefficient of variation of 10%. The results found in this study indicate that the concrete pry-out expression in German Technical Approval Z-26.4-56 can also be applied to Crestbond shear connectors.

RESUMO: Objetivou-se mensurar o efeito da associação entre caracteres agronômicos relacionados à produtividade de grãos de canola cultivada em diferentes épocas de semeadura, através da análise de trilha. Assim como também objetivou-se obter um método para predizer o teor de óleo nos grãos, ajustando um modelo multivariado através da análise por espectroscopia na região do infravermelho próximo. O experimento foi conduzido em campo, utilizando-se o delineamento de blocos ao acaso, em parcelas subdivididas no tempo, sendo quatro parcelas (épocas de semeadura) e seis subparcelas (híbridos de canola), com quatro repetições. Em cada híbrido foram realizadas observações fenológicas e determinada a produtividade de grãos. Os dados foram submetidos à análise de variância em ambiente R pelo teste F, a cinco de probabilidade. O teor de óleo nos grãos foi determinado pelo método químico tradicional, e com base na assinatura espectral no infravermelho próximo de amostras dos grãos foi estabelecida regressão dos mínimos quadrados parciais (PLS-R) para estimar o teor de óleo nos grãos de canola. As épocas de semeadura influenciaram os componentes de produção e o teor de óleo dos grãos de todos híbridos. Os caracteres número de grãos em cinco plantas (0,6857) e altura (0,4943) apresentaram maiores estimativas de correlação positiva com a produtividade de grãos, assim como os maiores valores de efeito direto positivo sobre a produtividade, 0,2494 e 0,1595 respectivamente. Entretanto, o ciclo total (-0,7848), juntamente com dias em florescimento (-0,4520) apresentou correlação significativa negativa com a produtividade. A técnica NIR associada à PLS-R foi capaz de predizer o teor de óleo nos grãos, resultando em bons modelos preditivos (R2 de 0,86 e RMSE de 1,56 na validação externa) que podem ser usados com sucesso na análise da qualidade das amostras após colheita e nos programas de melhoramento genético.

ABSTRACT: This study measured the effect of the association between agronomic traits related to the yield of canola grains grown at different sowing dates through path analysis. Another objective was to obtain a method to predict the oil content in the grains, fitting a multivariate model through near-infrared (NIR) spectroscopy analysis. The experiment was conducted in the field using a randomized block design in plots subdivided by time, with four plots (sowing dates), six subplots (canola hybrids), and four replicates. In each hybrid, phenological observations were performed, and the grain yield was determined. The data were subjected to analysis of variance in the R environment using the F test at 5% probability. The oil content in the grains was determined by the traditional chemical method, and based on the NIR spectral signature of the grain samples, partial least squares regression (PLS-R) was established to estimate the oil content in the canola grains. The sowing dates influenced the production components and oil content of the grains of all hybrids. The trait number of grains in five plants (0.6857) and their height (0.4943) had greater estimates of positive correlations with grain yield, as well as higher values of positive direct effects on yield (0.2494 and 0.1595, respectively). The NIR technique combined with PLS-R was able to predict the oil content in the grains, resulting in good predictive models (R2 of 0.86 and root mean square error (RMSE) of 1.56 in external validation).

ABSTRACT Determining what and how much each environmental factor affects pregnancy is crucial to the sustainability and management of beef cow herds. The study evaluated through logistic regression the effect of environmental variables on the increase or reduction in the pregnancy rate of beef cows. The average pregnancy rate in the cows was 73 %, with an average age for the herd of 3.7 years. An increase in age of one year represented a 30 % increase in pregnancy, while a reduction of one year reduced the odds of pregnancy in the cows by 23 %. During the lactation period, an extra seven days’ lactation reduced the odds of pregnancy by 12 %. For every seven days that weaning was brought forward, the cows’ pregnancy odds increased by 14 %. An increase of 0.1 kg in average daily gain represented an increase of 17 % and 15 % in the odds of pregnancy during the first 60 days post-partum and 60 days to the end of the reproductive period. On the other hand, the loss of 0.1 kg in average daily gain resulted in a 14 % and 13 % reduction in the cows’ pregnancy odds, respectively. Factors such as age, the precocity of calving in the calving season, the time the calf remains with the cow and better performance in cows between calving and the end of the mating are strategies that increase the chances of pregnancy in beef cows.

Abstract Potential variables for the reproductive success of beef cows were evaluated. Included in the model were the age of the cow at calving; the interval between the Julian calving date and the end of the breeding season; the body weight and conditions at calving, at 75 days post-partum and at the end of the breeding season; and the mean daily variation in weight between these dates. Logistic regression was used in the analysis, with the parameters evaluated using the odds ratio statistic, estimating the chance of pregnancy. The mean rate of pregnancy was 84% and 55% for early and late-weaned cows, respectively. For early weaned cows, the regression variables were the Julian calving date, age of the cow, weight gain from calving to 75 days post-partum, and from 75 days post-partum to the end of the reproductive period. For late-weaned cows, there were only two regression variables, weight at calving and weight gain from calving to the end of the reproductive period. For every year above the average age of the herd, early weaned cows have an 80.9% greater chance of pregnancy, while a reduction of one year reduces the chance of pregnancy by 44.7%. In early weaned cows, every seven days after the mean Julian calving date reduces the chances of pregnancy by 22.6%, whereas every seven days before the mean calving date increases pregnancy by 29.2%. Greater gains in cow body weight, from calving to the end of the reproductive period, determine a greater probability of pregnancy.

■ ABSTRACT Introduction: The oncological reconstruction of extensive defects in the head and neck requires the plastic surgeon to make a difficult decision between the use of free flaps and pedicled flaps. The supraclavicular flap is one of the main examples of a pedicled flap, being versatile, with a thin thickness and similar color to the region to be reconstructed. Method: A retrospective study was carried out by collecting data from medical records of patients admitted to the Cancer Institute of the State of São Paulo between December 2010 and March 2020. Results: Among the 62 patients reconstructed with a supraclavicular flap, 37 were male and 25 female. Fifty-eight patients (93.5%) had some associated comorbidity. In total, 27 complications related to the flap (43.5%) were recorded, 5 of which were total necrosis (8%). Conclusion: The supraclavicular flap plays an important role in head and neck oncological reconstructions and should be considered as an option in patients who are poor candidates for microsurgical flaps.

■ RESUMO Introdução: A reconstrução oncológica de defeitos extensos em cabeça e pescoço impõe ao cirurgião plástico a difícil decisão entre o uso de retalhos livres e retalhos pediculados. O retalho supraclavicular é um dos principais exemplos de retalho pediculado, sendo versátil, com espessura delgada e cor semelhante à região a ser reconstruída. Método: Um estudo retrospectivo foi realizado através da coleta de dados de prontuário de pacientes internados no Instituto do Câncer do Estado de São Paulo, entre dezembro de 2010 e março de 2020. Resultados: Dentre os 62 pacientes reconstruídos com retalho supraclavicular, 37 eram do sexo masculino e 25 do sexo feminino. Cinquenta e oito pacientes (93,5%) possuíam alguma comorbidade associada. Ao todo, 27 complicações relacionadas ao retalho (43,5%) foram registradas, sendo 5 necroses totais (8%). Conclusão: O retalho supraclavicular possui importante papel nas reconstruções oncológicas de cabeça e pescoço e deve ser considerado como opção em pacientes maus candidatos a retalhos microcirúrgicos.

Abstract The objective of this work was to evaluate, through meta-analysis, the impact of subcutaneous fat thickness on beef qualitative traits. Combined data from 13 studies were used, comprising 245 carcasses of male bovines slaughtered in Brazil. Effect size for all parameters was calculated as mean difference or standardized mean difference, at 95% probability. The meta-analysis of random and fixed effects was carried out when I2>50% and I2<50%, respectively, for each indicator separately, with means for fat thickness, classified in the “control” (3–6 mm), “low” (<3 mm), and “high” (>6 mm) groups. Carcasses in the “high” group showed greater intramuscular fat deposition, whereas those in the “low” group presented an intramuscular fat deposition similar to that of the control. When the fat thickness was below the recommended threshold of 3 mm, shear force increased. Subcutaneous fat thickness values greater than 6 mm induced a positive change in the perception of tenderness by the panel of evaluators. Beef carcasses with a subcutaneous fat thickness over 6 mm tend to accumulate more intramuscular fat content and are tenderer for consumers’ acceptance. Carcasses with a fat thickness less than 3 mm produce tougher meat.

Resumo O objetivo deste trabalho foi avaliar, por meio de meta-análise, o impacto da espessura de gordura subcutânea nas características qualitativas de carne bovina. Foram utilizados dados combinados de 13 estudos, compreendendo 245 carcaças de bovinos machos abatidos no Brasil. O tamanho do efeito para todos os parâmetros foi calculado como diferença média ou diferença média padronizada, a 95% de probabilidade. A meta-análise de efeitos aleatórios e fixos foi realizada quando I2>50% e I2<50%, respectivamente, para cada indicador separadamente, com as médias para espessura de gordura classificadas nos grupos “controle” (3–6 mm), “baixo” (<3 mm) e “alto” (>6 mm). As carcaças do grupo “alto” apresentaram maior deposição de gordura intramuscular, enquanto as do grupo “baixo” apresentaram deposição de gordura intramuscular semelhante à do controle. Quando a espessura da gordura estava abaixo do limite recomendado de 3 mm, a força de cisalhamento aumentou. Valores de espessura de gordura subcutânea maiores que 6 mm induziram mudança positiva na percepção de maciez pelo painel de avaliadores. As carcaças bovinas com espessura de gordura subcutânea superior a 6 mm tendem a acumular maior teor de gordura intramuscular e são mais macias para aceitação do consumidor. As carcaças com espessura de gordura inferior a 3 mm produzem carne mais dura.

Abstract BRS A705 is an early-maturing cultivar developed by Embrapa, recommended for irrigated cultivation. The plants have high tillering and moderate resistance to the main diseases. This cultivar has short stature, which confers a greater tolerance to lodging. It presents high yield and long and fine grains of excellent quality. A A70 earlymaturing early maturing Embrapa cultivation diseases stature lodging quality A7

ABSTRACT Background: Multiparametric magnetic resonance imaging improves the performance of prostate cancer (PCa) diagnostics through a better selection of patients. Objectives: The aim of the study was to study the detection rate (DR) of systematic and targeted cognitive biopsies in a cohort with the previous negative systematic biopsies. A secondary objective was to describe the value of prostate-specific antigen density (PSAd) in the detection of clinically significant PCa (CSPCa). Methods: We designed a prospective, single-center, and comparative study to determine the DR of systematic and targeted cognitive biopsies. The clinical and pathological characteristics of each patient were described. Results: A total of 111 patients with Prostate Imaging Reporting and Data System lesions > 3 were included in the study. PCa was detected in 41.4% (46 of 111 patients); 42 (91.3%) were detected by systematic biopsy and 30 (65.2%) by targeted biopsy. CSPCa was detected in 26 (23.4%), 23 (88.5%) by systematic biopsy, and 21 (76.9%) by targeted biopsy. PSAd > 0.15 was directly associated with CSPCa. Conclusion: The detection of PCa by systematic biopsy in this series was higher than 80%; hence, its routine use should not be replaced by targeted biopsy, since it continues to be the cornerstone of the diagnosis in patients with prior negative biopsies.

Abstract Cultivar BRS A706 CL is a new rice cultivar, resistant to herbicides of the chemical group of imidazolinones, with a yield potential of 15,635 kg ha-1. It has intermediate maturation, lodging tolerance, the stay green trait, moderate rice blast resistance, a high milling yield and premium grain quality.

Abstract BRS Pampa CL is a rice cultivar developed by Embrapa, recommended for irrigated cultivation in Rio Grande do Sul State, Brazil. It shows modern architecture, high tiller ing, early cycle, and tolerance to the imidazolinone herbicide Kifix®. It stands out for its high yield potential and excellent grain quality.

High-carbon steels have been used to high-strength steel wire and strands for prestressing concrete. The necessity of high-strength levels at increasingly larger diameters of wire rods is a technological challenge. Two steels with and without Nb were obtained in a steel mill, submitted to detailed microstructural (previous austenitic grain size, pearlite interlamellar spacing and colony size) and mechanical characterization through tensile tests and hardness. Hot torsion and dilatometry tests were performed to simulate steels processing and to verify the influence of Nb on phase transformation. Adding Nb to steel resulted in a refinement in austenitic grain size and pearlite colonies but had no effect on pearlitic interlamellar spacing. There was a decrease at the start transformation temperature austenite/pearlite and therefore an increase in the hardenability of the Nb-added steel. Finally, Nb addition proved to be a technical and economical way to increase tensile strength and to reduce the variability of the mechanical properties.

Summary: The objective of biofortification is the human consumption of high nutritional quality food, rich in micronutrients. Selenium (Se) is an essential micronutrient in human nutrition, and its essentiality has not been evidenced in plants. However, its application in crops and subsequent consumption can mitigate the deficiency of this micronutrient in the diet of human populations. This work analyzes the capacity of sodium selenite (Na2SeO3) to increase yield, biosynthesis of bioactive compounds and their accumulation in tomato fruits. For this, five treatments were applied via nutrient solution: 0, 2, 4, 6, and 8 mg L-1. At harvest, the nutraceutical quality and the accumulation of Se in fruits were quantified, as well as the productivity of tomato plant. Biofortification was positively affected by the biosynthesis of phytochemical compounds and their concentration in fruit, although tomato yield decreased. The incorporation of Se in nutritive solution is an alternative to increase both the biosynthesis of phytochemical compounds and the concentration of this element in tomato fruits with the possibility of improving public health through its consumption.

Resumen: El consumo de alimentos de alta calidad nutricional, ricos en micronutrientes para el ser humano es el objetivo de la biofortificación. El selenio (Se), es un micronutriente esencial en la nutrición humana, y en las plantas no se ha demostrado su esencialidad. Sin embargo, su aplicación en los cultivos y posterior consumo puede mitigar la deficiencia de este micronutrimento en la dieta de la población. El presente trabajo analiza la capacidad del selenito de sodio (Na2SeO3) para aumentar el rendimiento, biosíntesis de compuestos bioactivos y su acumulación en frutos de tomate. Para ello cinco tratamientos fueron aplicados vía solución nutritiva: 0, 2, 4, 6 y 8 mg L-1. En la cosecha, se cuantificó la calidad nutracéutica y la acumulación de Se en frutos, así como la productividad de la planta de tomate. La biofortificación se modificó positivamente con la biosíntesis de compuestos fitoquímicos y su concentración en fruto, pero disminuye el rendimiento de tomate. La incorporación de Se en la solución nutritiva es una alternativa para incrementar la biosíntesis de compuestos fitoquímicos e incrementar la concentración de este elemento en los frutos del tomate con la posibilidad de mejorar la salud pública con su consumo.